GPX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.23941878
2daunorubicin metabolic process (GO:0044597)6.88802220
3polyketide metabolic process (GO:0030638)6.88802220
4doxorubicin metabolic process (GO:0044598)6.88802220
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.54546082
6intestinal epithelial cell development (GO:0060576)6.37548243
7intestinal cholesterol absorption (GO:0030299)6.26924761
8aminoglycoside antibiotic metabolic process (GO:0030647)6.07986106
9regulation of respiratory burst (GO:0060263)5.98342834
10cellular glucuronidation (GO:0052695)5.39953468
11complement activation, classical pathway (GO:0006958)5.33058539
12ethanol oxidation (GO:0006069)5.29387672
13glucuronate metabolic process (GO:0019585)5.25779570
14uronic acid metabolic process (GO:0006063)5.25779570
15calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.21524812
16UDP-N-acetylglucosamine metabolic process (GO:0006047)5.05366161
17angiotensin maturation (GO:0002003)4.90036066
18L-phenylalanine metabolic process (GO:0006558)4.89757942
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.89757942
20regulation of chemokine secretion (GO:0090196)4.89015255
21antibacterial humoral response (GO:0019731)4.84306607
22regulation of protein activation cascade (GO:2000257)4.83639743
23digestive system process (GO:0022600)4.83579470
24hepatocyte apoptotic process (GO:0097284)4.82257972
25antimicrobial humoral response (GO:0019730)4.77216843
26regulation of complement activation (GO:0030449)4.70285123
27ribosomal small subunit assembly (GO:0000028)4.65190247
28epoxygenase P450 pathway (GO:0019373)4.59835542
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53608852
30L-phenylalanine catabolic process (GO:0006559)4.53608852
31complement activation (GO:0006956)4.51178812
32membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.44616627
33flavonoid metabolic process (GO:0009812)4.44055595
34regulation of bile acid biosynthetic process (GO:0070857)4.42996684
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.39283596
36proline biosynthetic process (GO:0006561)4.37930764
37maintenance of gastrointestinal epithelium (GO:0030277)4.35953848
38acute-phase response (GO:0006953)4.34823816
39complement activation, alternative pathway (GO:0006957)4.32047507
40very-low-density lipoprotein particle assembly (GO:0034379)4.25297842
41regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.24945302
42GDP-mannose metabolic process (GO:0019673)4.22152150
43viral transcription (GO:0019083)4.21107269
44protein activation cascade (GO:0072376)4.16275317
45urea metabolic process (GO:0019627)4.12382887
46negative regulation of keratinocyte proliferation (GO:0010839)4.07265797
47glycoside metabolic process (GO:0016137)4.06968923
48actin filament depolymerization (GO:0030042)4.04887808
49translational termination (GO:0006415)4.04827655
50regulation of hydrogen peroxide metabolic process (GO:0010310)4.04757958
51urea cycle (GO:0000050)4.02824321
52desmosome organization (GO:0002934)4.01200598
53vitamin A metabolic process (GO:0006776)3.99117717
54virion attachment to host cell (GO:0019062)3.98515889
55adhesion of symbiont to host cell (GO:0044650)3.98515889
56interferon-gamma secretion (GO:0072643)3.96472609
57membrane repolarization during action potential (GO:0086011)3.95953623
58regulation of cholesterol homeostasis (GO:2000188)3.95293152
59ventricular cardiac muscle cell action potential (GO:0086005)3.93312800
60bile acid and bile salt transport (GO:0015721)3.93212340
61hemidesmosome assembly (GO:0031581)3.91786367
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87918152
63ATP synthesis coupled proton transport (GO:0015986)3.87918152
64phenylpropanoid metabolic process (GO:0009698)3.86966097
65regulation of cellular extravasation (GO:0002691)3.84839364
66negative regulation of epidermal cell differentiation (GO:0045605)3.82766369
67ribosomal large subunit biogenesis (GO:0042273)3.81955179
68drug metabolic process (GO:0017144)3.81263328
69O-glycan processing (GO:0016266)3.80099325
70bile acid metabolic process (GO:0008206)3.78453091
71opsonization (GO:0008228)3.78158063
72endocrine pancreas development (GO:0031018)3.77414000
73tight junction assembly (GO:0070830)3.71628686
74ethanol metabolic process (GO:0006067)3.71380426
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71009146
76protein-lipid complex remodeling (GO:0034368)3.70422200
77macromolecular complex remodeling (GO:0034367)3.70422200
78plasma lipoprotein particle remodeling (GO:0034369)3.70422200
79nitrogen cycle metabolic process (GO:0071941)3.70108080
80primary alcohol catabolic process (GO:0034310)3.68897858
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.68408878
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.68408878
83arginine metabolic process (GO:0006525)3.64764947
84exogenous drug catabolic process (GO:0042738)3.63818998
85regulation of cholesterol esterification (GO:0010872)3.63664481
86protein targeting to ER (GO:0045047)3.63482028
87regulation of fibrinolysis (GO:0051917)3.61255632
88cotranslational protein targeting to membrane (GO:0006613)3.60880432
89protein carboxylation (GO:0018214)3.60190029
90peptidyl-glutamic acid carboxylation (GO:0017187)3.60190029
91plasma lipoprotein particle assembly (GO:0034377)3.59436116
92acute inflammatory response (GO:0002526)3.59352568
93low-density lipoprotein particle remodeling (GO:0034374)3.58504241
94negative regulation of fibrinolysis (GO:0051918)3.53030928
95primary alcohol metabolic process (GO:0034308)3.50608389
96nucleotide-sugar biosynthetic process (GO:0009226)3.50126878
97maturation of SSU-rRNA (GO:0030490)3.47883500
98defense response to fungus (GO:0050832)3.47825217
99innate immune response in mucosa (GO:0002227)3.46539086
100cell differentiation involved in embryonic placenta development (GO:0060706)3.45584615
101translational elongation (GO:0006414)3.44780780
102establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44126376
103positive regulation of digestive system process (GO:0060456)3.42795171
104keratinocyte proliferation (GO:0043616)3.41402460
105progesterone metabolic process (GO:0042448)3.39292105
106protein localization to endoplasmic reticulum (GO:0070972)3.38762107
107viral life cycle (GO:0019058)3.38612577
108cellular protein complex disassembly (GO:0043624)3.37508870
109negative regulation of protein activation cascade (GO:2000258)3.35532768
110retinal metabolic process (GO:0042574)3.33224624
111ribosomal small subunit biogenesis (GO:0042274)3.32858193
112regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.31793762
113sulfation (GO:0051923)3.31058493
114regulation of triglyceride catabolic process (GO:0010896)3.30678632
115glandular epithelial cell differentiation (GO:0002067)3.30414795
116high-density lipoprotein particle remodeling (GO:0034375)3.29792645
117positive regulation of chemokine secretion (GO:0090197)3.29409810
118plasma lipoprotein particle organization (GO:0071827)3.28601157
119thyroid hormone metabolic process (GO:0042403)3.28331736
120drug transmembrane transport (GO:0006855)3.27592985
121vitamin transmembrane transport (GO:0035461)3.26669980
122protein autoprocessing (GO:0016540)3.25787097
123trophectodermal cell differentiation (GO:0001829)3.21113518
124triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20498447
125regulation of keratinocyte proliferation (GO:0010837)3.19352411
126purine nucleotide salvage (GO:0032261)3.18080547
127phospholipid efflux (GO:0033700)3.17764777
128transcytosis (GO:0045056)3.17662581
129protein-lipid complex assembly (GO:0065005)3.17545451
130cholesterol efflux (GO:0033344)3.16560497
131epithelial structure maintenance (GO:0010669)3.14586941
132negative regulation of sterol transport (GO:0032372)3.14363718
133negative regulation of cholesterol transport (GO:0032375)3.14363718
134positive regulation of epidermal cell differentiation (GO:0045606)3.12052444
135digestion (GO:0007586)3.12047222
136positive regulation of lipoprotein lipase activity (GO:0051006)3.09733154
137positive regulation of triglyceride lipase activity (GO:0061365)3.09733154
138drug catabolic process (GO:0042737)3.08294953
139protein-lipid complex subunit organization (GO:0071825)3.07620489
140regulation of metalloenzyme activity (GO:0048552)3.07201330
141regulation of heart rate by cardiac conduction (GO:0086091)3.07169179
142NADH metabolic process (GO:0006734)3.06903397
143proline metabolic process (GO:0006560)3.06027252
144adhesion of symbiont to host (GO:0044406)3.05285421
145phospholipid scrambling (GO:0017121)3.04599077
146diol metabolic process (GO:0034311)3.03722144
147cytidine deamination (GO:0009972)3.03207610
148cytidine metabolic process (GO:0046087)3.03207610
149cytidine catabolic process (GO:0006216)3.03207610
150arginine catabolic process (GO:0006527)3.02580493
151positive regulation of respiratory burst (GO:0060267)3.00186207
152negative regulation of complement activation (GO:0045916)2.99450434
153transepithelial transport (GO:0070633)2.99418410
154drug transport (GO:0015893)2.99408272
155modified amino acid transport (GO:0072337)2.99032155
156quinone metabolic process (GO:1901661)2.98863395
157regulation of viral release from host cell (GO:1902186)2.98461275
158mucosal immune response (GO:0002385)2.98447736
159activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.97956409
160respiratory electron transport chain (GO:0022904)2.97840349
161cardiovascular system development (GO:0072358)2.97575493
162regulation of apoptotic cell clearance (GO:2000425)2.97146951
163regulation of transforming growth factor beta1 production (GO:0032908)2.97080741
164glucose 6-phosphate metabolic process (GO:0051156)2.96747190
165glutathione derivative biosynthetic process (GO:1901687)2.96090432
166glutathione derivative metabolic process (GO:1901685)2.96090432
167negative regulation of coagulation (GO:0050819)2.95974473
168negative regulation of glial cell proliferation (GO:0060253)2.94716136
169positive regulation of interleukin-8 secretion (GO:2000484)2.94451760
170reverse cholesterol transport (GO:0043691)2.92419496
171electron transport chain (GO:0022900)2.92251349
172aromatic amino acid family catabolic process (GO:0009074)2.91681503
173positive regulation of lipid catabolic process (GO:0050996)2.91003119
174negative regulation of blood coagulation (GO:0030195)2.90872917
175negative regulation of hemostasis (GO:1900047)2.90872917
176translational initiation (GO:0006413)2.89437772
177diacylglycerol metabolic process (GO:0046339)2.89300191
178lung secretory cell differentiation (GO:0061140)2.89135659
179cellular aldehyde metabolic process (GO:0006081)2.88886231
180regulation of water loss via skin (GO:0033561)2.87763498
181sulfur amino acid catabolic process (GO:0000098)2.85379028
182acylglycerol homeostasis (GO:0055090)2.85247362
183triglyceride homeostasis (GO:0070328)2.85247362
184cholesterol homeostasis (GO:0042632)2.85146658
185alkaloid metabolic process (GO:0009820)2.84735848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human8.21994111
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.32125579
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.93381289
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.80144243
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.56333391
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.31098908
7* GATA4_25053715_ChIP-Seq_YYC3_Human3.19560832
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.09625311
9GATA6_25053715_ChIP-Seq_YYC3_Human3.06518280
10* SOX2_20726797_ChIP-Seq_SW620_Human2.83729485
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.76840348
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.33837211
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23528605
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21132454
15* FOXA2_19822575_ChIP-Seq_HepG2_Human2.18780384
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.15448354
17AR_21909140_ChIP-Seq_LNCAP_Human2.15046411
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.11341863
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00017820
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96527008
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.91180748
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90366857
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87667775
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86904166
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83819118
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83016322
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.82100002
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81131897
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75171060
30ATF3_27146783_Chip-Seq_COLON_Human1.75002173
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74964359
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74933445
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72203008
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71613880
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.70017183
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69477839
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68052419
38ZNF263_19887448_ChIP-Seq_K562_Human1.63422897
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.60008786
40RACK7_27058665_Chip-Seq_MCF-7_Human1.58591823
41KLF5_25053715_ChIP-Seq_YYC3_Human1.58004123
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56195892
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54831530
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54172488
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54172488
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50310539
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49773494
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.47958168
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46639172
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43722838
51OCT4_18692474_ChIP-Seq_MEFs_Mouse1.42492265
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42431045
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42272577
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.41609050
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.41514369
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41090766
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.41002790
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39677923
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37158182
60LXR_22292898_ChIP-Seq_THP-1_Human1.36993748
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34663732
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34528840
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30739424
64ELF5_23300383_ChIP-Seq_T47D_Human1.28053667
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27747339
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26491778
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26169170
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25725821
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.21728944
70* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20657195
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20111160
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.18978545
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18411690
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16695604
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16000577
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14960663
77NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14919363
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14613230
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.13438110
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11591609
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11079183
82* GATA3_24758297_ChIP-Seq_MCF-7_Human1.10904362
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09132493
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07515989
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.03654537
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02491401
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.02466542
88CEBPB_22108803_ChIP-Seq_LS180_Human0.99530379
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98475845
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97394567
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97151899
92GABP_17652178_ChIP-ChIP_JURKAT_Human0.96439944
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95604164
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95101582
95XRN2_22483619_ChIP-Seq_HELA_Human0.94585517
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94089582
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93326186
98CDX2_22108803_ChIP-Seq_LS180_Human0.92287212
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90278118
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.90263511
101PHF8_20622854_ChIP-Seq_HELA_Human0.90246414
102NANOG_20526341_ChIP-Seq_ESCs_Human0.89881476
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89795954
104BCOR_27268052_Chip-Seq_Bcells_Human0.89505330
105* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89322308
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89320887
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88685759
108CLOCK_20551151_ChIP-Seq_293T_Human0.87868249
109TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86243947
110* TP63_22573176_ChIP-Seq_HFKS_Human0.85939422
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85754447
112CHD1_26751641_Chip-Seq_LNCaP_Human0.85577338
113DCP1A_22483619_ChIP-Seq_HELA_Human0.85265872
114EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84934909
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84706829
116JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83546027
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82594764
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81580619
119E2F1_20622854_ChIP-Seq_HELA_Human0.81169839
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79590999
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.79499068
122* SOX17_20123909_ChIP-Seq_XEN_Mouse0.79103870
123MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79009497
124SA1_27219007_Chip-Seq_Bcells_Human0.78997454
125CREB1_26743006_Chip-Seq_LNCaP_Human0.77719948
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76857200
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76564947
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76503675
129TTF2_22483619_ChIP-Seq_HELA_Human0.76435670
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76203625
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75862839
132SOX2_21211035_ChIP-Seq_LN229_Human0.73674576
133CTCF_27219007_Chip-Seq_Bcells_Human0.73521868
134BCL6_27268052_Chip-Seq_Bcells_Human0.70090933
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69631177
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69615545
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69422386
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69289162
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69059862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.75944284
2MP0005360_urolithiasis5.05349246
3MP0004264_abnormal_extraembryonic_tissu4.44224266
4MP0009379_abnormal_foot_pigmentation4.26918004
5MP0001666_abnormal_nutrient_absorption3.94169370
6MP0000462_abnormal_digestive_system3.91358790
7MP0008004_abnormal_stomach_pH3.43814871
8MP0003195_calcinosis3.30609669
9MP0003866_abnormal_defecation3.20986683
10MP0000537_abnormal_urethra_morphology3.13045197
11MP0000490_abnormal_crypts_of2.84015990
12MP0003300_gastrointestinal_ulcer2.70824163
13MP0010155_abnormal_intestine_physiology2.64651227
14MP0001873_stomach_inflammation2.59574262
15MP0010352_gastrointestinal_tract_polyps2.45526756
16MP0002139_abnormal_hepatobiliary_system2.43221245
17MP0001663_abnormal_digestive_system2.40756630
18MP0005085_abnormal_gallbladder_physiolo2.36298640
19MP0005381_digestive/alimentary_phenotyp2.29748204
20MP0009840_abnormal_foam_cell2.10562077
21MP0003806_abnormal_nucleotide_metabolis2.10110906
22MP0001664_abnormal_digestion2.04604114
23MP0003693_abnormal_embryo_hatching2.03952032
24MP0000477_abnormal_intestine_morphology2.01935278
25MP0004019_abnormal_vitamin_homeostasis1.80536781
26MP0003252_abnormal_bile_duct1.80288840
27MP0002796_impaired_skin_barrier1.76359897
28MP0006054_spinal_hemorrhage1.73930305
29MP0001849_ear_inflammation1.69577581
30MP0002277_abnormal_respiratory_mucosa1.68380736
31MP0002098_abnormal_vibrissa_morphology1.66718869
32MP0003183_abnormal_peptide_metabolism1.66591111
33MP0000538_abnormal_urinary_bladder1.66291460
34MP0003453_abnormal_keratinocyte_physiol1.62647717
35MP0008875_abnormal_xenobiotic_pharmacok1.58406867
36MP0002118_abnormal_lipid_homeostasis1.45115933
37MP0010678_abnormal_skin_adnexa1.42860272
38MP0000470_abnormal_stomach_morphology1.34471833
39MP0003123_paternal_imprinting1.34125644
40MP0004957_abnormal_blastocyst_morpholog1.33625837
41MP0000613_abnormal_salivary_gland1.31781832
42MP0003315_abnormal_perineum_morphology1.30116625
43MP0000678_abnormal_parathyroid_gland1.28974409
44MP0009643_abnormal_urine_homeostasis1.27806221
45MP0001756_abnormal_urination1.26715868
46MP0005501_abnormal_skin_physiology1.24950861
47MP0002254_reproductive_system_inflammat1.24539123
48MP0008872_abnormal_physiological_respon1.24169431
49MP0001764_abnormal_homeostasis1.22106325
50MP0000566_synostosis1.20956742
51MP0003191_abnormal_cellular_cholesterol1.20298108
52MP0010329_abnormal_lipoprotein_level1.17231923
53MP0000467_abnormal_esophagus_morphology1.16418483
54MP0004043_abnormal_pH_regulation1.13628395
55MP0009780_abnormal_chondrocyte_physiolo1.13132902
56MP0001485_abnormal_pinna_reflex1.11470720
57MP0001216_abnormal_epidermal_layer1.07396293
58MP0003787_abnormal_imprinting1.06222251
59MP0003283_abnormal_digestive_organ1.05982577
60MP0003878_abnormal_ear_physiology1.04265066
61MP0005377_hearing/vestibular/ear_phenot1.04265066
62MP0005670_abnormal_white_adipose1.03451423
63MP0005409_darkened_coat_color1.01861536
64MP0005451_abnormal_body_composition1.00690981
65MP0002060_abnormal_skin_morphology1.00336045
66MP0003941_abnormal_skin_development0.99952014
67MP0002138_abnormal_hepatobiliary_system0.98205725
68MP0005365_abnormal_bile_salt0.97674525
69MP0003718_maternal_effect0.95111088
70MP0003119_abnormal_digestive_system0.94973727
71MP0002132_abnormal_respiratory_system0.94055112
72MP0005084_abnormal_gallbladder_morpholo0.93032765
73MP0009697_abnormal_copulation0.90089941
74MP0003186_abnormal_redox_activity0.89910355
75MP0005023_abnormal_wound_healing0.87690597
76MP0004782_abnormal_surfactant_physiolog0.87575009
77MP0005584_abnormal_enzyme/coenzyme_acti0.87036013
78MP0001765_abnormal_ion_homeostasis0.85306867
79MP0005636_abnormal_mineral_homeostasis0.84500613
80MP0002876_abnormal_thyroid_physiology0.84044098
81MP0000579_abnormal_nail_morphology0.83339225
82MP0010386_abnormal_urinary_bladder0.80549591
83MP0009642_abnormal_blood_homeostasis0.78433759
84MP0010771_integument_phenotype0.77794606
85MP0005058_abnormal_lysosome_morphology0.77364073
86MP0003705_abnormal_hypodermis_morpholog0.75138378
87MP0004947_skin_inflammation0.75115336
88MP0005165_increased_susceptibility_to0.72615079
89MP0002909_abnormal_adrenal_gland0.72142220
90MP0000762_abnormal_tongue_morphology0.71906100
91MP0005220_abnormal_exocrine_pancreas0.71049533
92MP0000516_abnormal_urinary_system0.70755063
93MP0005367_renal/urinary_system_phenotyp0.70755063
94MP0008469_abnormal_protein_level0.70258561
95MP0005408_hypopigmentation0.70006810
96MP0004858_abnormal_nervous_system0.68886989
97MP0001845_abnormal_inflammatory_respons0.68518319
98MP0002822_catalepsy0.66903841
99MP0005248_abnormal_Harderian_gland0.66375967
100MP0005167_abnormal_blood-brain_barrier0.66167149
101MP0002078_abnormal_glucose_homeostasis0.65789984
102MP0005448_abnormal_energy_balance0.64841597
103MP0005166_decreased_susceptibility_to0.63512905
104MP0003879_abnormal_hair_cell0.63389956
105MP0002089_abnormal_postnatal_growth/wei0.63373771
106MP0005187_abnormal_penis_morphology0.63335445
107MP0004147_increased_porphyrin_level0.63175959
108MP0002166_altered_tumor_susceptibility0.62741813
109MP0009785_altered_susceptibility_to0.61725504
110MP0003953_abnormal_hormone_level0.61487881
111MP0002136_abnormal_kidney_physiology0.60334457
112MP0010030_abnormal_orbit_morphology0.59628059
113MP0000377_abnormal_hair_follicle0.59258482
114MP0000465_gastrointestinal_hemorrhage0.58027332
115MP0000598_abnormal_liver_morphology0.57766937
116MP0002971_abnormal_brown_adipose0.56520459
117MP0005083_abnormal_biliary_tract0.56495293
118MP0000604_amyloidosis0.55606398
119MP0005319_abnormal_enzyme/_coenzyme0.55016011
120MP0005164_abnormal_response_to0.55007879
121MP0003638_abnormal_response/metabolism_0.53949924
122MP0005310_abnormal_salivary_gland0.53587762
123MP0005332_abnormal_amino_acid0.53396984
124MP0005376_homeostasis/metabolism_phenot0.53131925
125MP0002693_abnormal_pancreas_physiology0.52214385
126MP0003075_altered_response_to0.51913371
127MP0001191_abnormal_skin_condition0.51803577
128MP0002163_abnormal_gland_morphology0.51627449
129MP0001730_embryonic_growth_arrest0.51174911
130MP0000627_abnormal_mammary_gland0.51087880
131MP0003868_abnormal_feces_composition0.50593438
132MP0000609_abnormal_liver_physiology0.48921354
133MP0003329_amyloid_beta_deposits0.48226064
134MP0001944_abnormal_pancreas_morphology0.45719070

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.34981094
2Right ventricular cardiomyopathy (HP:0011663)5.93717036
3Ventricular fibrillation (HP:0001663)5.88116712
4Complement deficiency (HP:0004431)5.68431751
5Deep venous thrombosis (HP:0002625)5.62041470
6Systemic lupus erythematosus (HP:0002725)5.43210736
7Abnormality of complement system (HP:0005339)4.88398562
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.75775951
9Abnormal hemoglobin (HP:0011902)4.58928913
10Glomerulonephritis (HP:0000099)4.53088351
11Congenital sensorineural hearing impairment (HP:0008527)4.47632085
12Prolonged partial thromboplastin time (HP:0003645)4.41075223
13Pustule (HP:0200039)4.28835852
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01386728
15Hemorrhage of the eye (HP:0011885)3.89082166
16Vascular calcification (HP:0004934)3.79506213
17Xanthomatosis (HP:0000991)3.66867502
18Onycholysis (HP:0001806)3.65402802
19Pili torti (HP:0003777)3.48721383
20Cheilitis (HP:0100825)3.45464061
21Abdominal distention (HP:0003270)3.44765006
22Woolly hair (HP:0002224)3.44489347
23Rectal prolapse (HP:0002035)3.44064003
24Trismus (HP:0000211)3.43064090
25Villous atrophy (HP:0011473)3.42867341
26Abnormality of small intestinal villus morphology (HP:0011472)3.42867341
27Micronodular cirrhosis (HP:0001413)3.35504755
28Conjugated hyperbilirubinemia (HP:0002908)3.32961946
29Abnormal biliary tract morphology (HP:0012440)3.30907483
30Malnutrition (HP:0004395)3.26140486
31Nephritis (HP:0000123)3.22926418
32Cardiovascular calcification (HP:0011915)3.22612595
33Steatorrhea (HP:0002570)3.21576414
34Abnormality of the gastric mucosa (HP:0004295)3.12270458
35Biliary tract neoplasm (HP:0100574)3.12008103
36Fragile nails (HP:0001808)3.11360634
37Ankyloglossia (HP:0010296)3.05685431
38Abnormality of urine glucose concentration (HP:0011016)3.05379736
39Glycosuria (HP:0003076)3.05379736
40Abnormality of proline metabolism (HP:0010907)2.98747451
41Hydroxyprolinuria (HP:0003080)2.98747451
42Milia (HP:0001056)2.97499323
43Reticulocytopenia (HP:0001896)2.97156524
44Hypolipoproteinemia (HP:0010981)2.96742744
45Flat acetabular roof (HP:0003180)2.94684692
46Decreased circulating renin level (HP:0003351)2.89893329
47Syncope (HP:0001279)2.87701624
48Palpitations (HP:0001962)2.84361556
49Joint hemorrhage (HP:0005261)2.83590318
50Amniotic constriction ring (HP:0009775)2.81591480
51Abnormality of placental membranes (HP:0011409)2.81591480
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81449283
53Plantar hyperkeratosis (HP:0007556)2.79968726
54Hyperactive renin-angiotensin system (HP:0000841)2.79681123
55Colon cancer (HP:0003003)2.75604792
56Alkalosis (HP:0001948)2.74991679
57Abnormality of renin-angiotensin system (HP:0000847)2.73257689
58Lipid accumulation in hepatocytes (HP:0006561)2.71092558
59Autoimmune hemolytic anemia (HP:0001890)2.68124792
60Abnormal tarsal ossification (HP:0008369)2.67206192
61Microretrognathia (HP:0000308)2.67101259
62Focal segmental glomerulosclerosis (HP:0000097)2.64736917
63Hyperammonemia (HP:0001987)2.62906754
64Increased hepatocellular lipid droplets (HP:0006565)2.62409847
65Hypoglycemic coma (HP:0001325)2.60992217
66Fragile skin (HP:0001030)2.60882584
67Curly hair (HP:0002212)2.60091562
68Abnormality of chloride homeostasis (HP:0011422)2.58849575
69Abnormality of pyrimidine metabolism (HP:0004353)2.57694826
70Hyperparathyroidism (HP:0000843)2.56932794
71Premature loss of primary teeth (HP:0006323)2.54968641
72Posterior subcapsular cataract (HP:0007787)2.52862076
73Abnormality of the common coagulation pathway (HP:0010990)2.51812942
74Increased muscle lipid content (HP:0009058)2.51583194
75Autoimmune thrombocytopenia (HP:0001973)2.51002178
76Increased intramyocellular lipid droplets (HP:0012240)2.50737954
77Hyperphosphaturia (HP:0003109)2.49789571
78Glomerulosclerosis (HP:0000096)2.45739686
79Poikiloderma (HP:0001029)2.45467117
80Hepatic necrosis (HP:0002605)2.44496597
81Macrocytic anemia (HP:0001972)2.43237527
82Potter facies (HP:0002009)2.43047926
83Facial shape deformation (HP:0011334)2.43047926
84Uterine neoplasm (HP:0010784)2.43002478
85Spontaneous abortion (HP:0005268)2.42067440
86Dehydration (HP:0001944)2.41080186
87Atrophic scars (HP:0001075)2.39132347
88Hypobetalipoproteinemia (HP:0003563)2.37578177
89Ridged nail (HP:0001807)2.37286715
90Ventricular arrhythmia (HP:0004308)2.36310563
91Hypotension (HP:0002615)2.35512254
92Gout (HP:0001997)2.34165005
93Abnormality of carpal bone ossification (HP:0006257)2.33957907
94Hepatocellular necrosis (HP:0001404)2.33825138
95Mitochondrial inheritance (HP:0001427)2.32973092
96Gastrointestinal dysmotility (HP:0002579)2.31859949
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27112945
98Late onset (HP:0003584)2.26032659
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.23531657
100Abnormality of cells of the erythroid lineage (HP:0012130)2.23362731
101Hypercholesterolemia (HP:0003124)2.22135149
102Hypercortisolism (HP:0001578)2.21531236
103Symptomatic seizures (HP:0011145)2.20748544
104Neoplasm of the small intestine (HP:0100833)2.19926437
105Neoplasm of the rectum (HP:0100743)2.17588124
106Increased purine levels (HP:0004368)2.16924266
107Hyperuricemia (HP:0002149)2.16924266
108Malignant gastrointestinal tract tumors (HP:0006749)2.16710328
109Gastrointestinal carcinoma (HP:0002672)2.16710328
110Goiter (HP:0000853)2.16351589
111Pigmentary retinal degeneration (HP:0001146)2.16168514
112Abnormality of serine family amino acid metabolism (HP:0010894)2.15260961
113Abnormality of glycine metabolism (HP:0010895)2.15260961
114Abnormality of nucleobase metabolism (HP:0010932)2.13939132
115Abnormality of the vitamin B12 metabolism (HP:0004341)2.13154528
116Widely patent fontanelles and sutures (HP:0004492)2.13102012
117Abnormal blistering of the skin (HP:0008066)2.10521515
118Fat malabsorption (HP:0002630)2.10366772
119Abnormality of the distal phalanges of the toes (HP:0010182)2.09215795
120Acanthocytosis (HP:0001927)2.08885218
121Rickets (HP:0002748)2.08318375
12211 pairs of ribs (HP:0000878)2.08217431
123Exocrine pancreatic insufficiency (HP:0001738)2.07392136
124Hyperlipoproteinemia (HP:0010980)2.06413943
125Hyperglycemia (HP:0003074)2.05599532
126Abnormality of vitamin B metabolism (HP:0004340)2.03957043
127Abnormal hair laboratory examination (HP:0003328)2.02959161
128Hyperglycinuria (HP:0003108)2.02424946
129Neoplasm of the colon (HP:0100273)2.01733758
130Proximal tubulopathy (HP:0000114)2.01542275
131Abnormal urine phosphate concentration (HP:0012599)2.01518876
132Exertional dyspnea (HP:0002875)2.01338923
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01320775
134Xerostomia (HP:0000217)2.00315657
135Abnormal sex determination (HP:0012244)1.99648654
136Sex reversal (HP:0012245)1.99648654
137Increased CSF lactate (HP:0002490)1.98803102
138Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98651714
139Metabolic alkalosis (HP:0200114)1.95177417
140Periodontitis (HP:0000704)1.94636477
141Rough bone trabeculation (HP:0100670)1.94151059
142Abnormality of purine metabolism (HP:0004352)1.93884439
143Azoospermia (HP:0000027)1.93408823
144Hypoalphalipoproteinemia (HP:0003233)1.92779763
145Abnormality of oral frenula (HP:0000190)1.92640167
146Hypoglycemic seizures (HP:0002173)1.92324927
147Abnormal number of erythroid precursors (HP:0012131)1.91814899
148Hypoplasia of the uterus (HP:0000013)1.91738617
149Purpura (HP:0000979)1.90939775
150Metabolic acidosis (HP:0001942)1.90665294
151Epidermoid cyst (HP:0200040)1.90519964
152Intrahepatic cholestasis (HP:0001406)1.90276335
153Abnormality of vitamin metabolism (HP:0100508)1.88194455
154Chronic diarrhea (HP:0002028)1.87047321
155Acute encephalopathy (HP:0006846)1.86890633
156Hyponatremia (HP:0002902)1.85940622
157Abnormal pancreas size (HP:0012094)1.85820426
158Gingival bleeding (HP:0000225)1.83292415
159Pancreatitis (HP:0001733)1.83144679
160Hyperaldosteronism (HP:0000859)1.79071889
161Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78717017
162Hepatocellular carcinoma (HP:0001402)1.78329198
163Renal tubular acidosis (HP:0001947)1.77972315
164Recurrent gram-negative bacterial infections (HP:0005420)1.77165498
165Skin nodule (HP:0200036)1.74205189
166Cerebral palsy (HP:0100021)1.74093949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.67683413
2EPHA25.59562580
3FRK4.82480206
4MST1R4.00102998
5MST43.96325547
6NME13.16911177
7MAP2K23.15714722
8PBK2.62559647
9FGFR42.55811133
10PRKG22.50011064
11MAP2K62.44059995
12MAP3K22.26483344
13ACVR1B2.18814693
14NUAK12.16706210
15TESK12.01899065
16EPHB21.81354581
17MAP3K121.79942425
18RIPK11.66672555
19TLK11.61672392
20PAK41.60841339
21TTK1.58778309
22FGFR31.53195642
23MAP3K31.52992898
24SIK11.50045016
25STK241.46886043
26MAP3K111.39974565
27PTK61.39186652
28FER1.37648939
29MET1.36576013
30RPS6KB21.27275073
31PTK21.22957617
32EIF2AK11.20001270
33STK391.18659942
34NME21.16149623
35PIM21.13647971
36PRKCI1.08375968
37BUB11.07662058
38MYLK1.06929198
39GRK61.05601400
40MAP2K11.03224596
41ERBB31.01732251
42ERBB21.00880556
43ICK0.96709165
44AURKB0.94189112
45NEK90.91336328
46MAPK150.86113409
47CDC42BPA0.81876478
48TRIB30.78500891
49ERN10.77221836
50MAP3K80.76525793
51TAOK30.75746677
52IRAK30.74422780
53EPHA30.73683170
54MAP3K90.72594281
55STK38L0.72254909
56PHKG10.71831045
57PHKG20.71831045
58IRAK10.69465937
59WNK40.68774837
60CDK190.64568163
61TYK20.64442265
62MAP3K10.64069040
63BMX0.63269656
64PDPK10.62608643
65SMG10.62418490
66MAP3K100.61882735
67EPHB10.61719770
68SCYL20.59784078
69LATS10.59140052
70PASK0.59036385
71LIMK10.57996437
72NLK0.56988554
73PIK3CA0.56457607
74MAPKAPK30.55274467
75CAMK2D0.54681751
76GRK10.52675222
77CAMK2B0.52488471
78CAMK2G0.51320815
79DYRK1B0.51311666
80BMPR1B0.51144800
81KSR20.49061012
82RPS6KA40.47862035
83CDK60.47583936
84MAP3K130.47445156
85MATK0.43026933
86NEK10.42026594
87LRRK20.41971074
88MELK0.41163028
89PDK20.41158823
90BCR0.40763917
91MAP3K70.39887049
92ERBB40.39758418
93PLK10.38838877
94BMPR20.38747100
95INSRR0.38352755
96PRKAA10.37575134
97PRKACG0.36896969
98PDK10.35825242
99PRKCZ0.34597954
100OXSR10.34419521
101BLK0.33389040
102FGR0.33307989
103STK100.33024302
104PAK10.32801830
105TAOK10.32641900
106PRKD30.31964628
107MAPK110.31110585
108PAK30.30588445
109DDR20.30572294
110PDGFRA0.29645644
111SRC0.29102618
112VRK10.28985270
113TESK20.28825912
114CDK120.27312691
115FGFR20.27305675
116AKT30.26966397
117PKN20.26069877
118CSNK1A10.25833340
119MAP3K140.25790118
120CHUK0.24871726
121IRAK40.23702844
122IRAK20.22975425
123PRKCA0.22906269
124FGFR10.22448043
125DAPK30.22072644
126HIPK20.22048904
127IGF1R0.21894647
128PRKCQ0.21299747
129DAPK10.21115374
130PRKCE0.20304969
131CDK70.20231899
132STK380.19545682
133STK30.18476488
134TBK10.18383128
135AURKA0.17962074
136CSNK1E0.17484603
137ARAF0.17433968
138BRAF0.16314712
139PRKAA20.16121319
140PDK30.16076131
141PDK40.16076131
142STK40.15583168
143ZAP700.15232877
144PRKCD0.14943427

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.16927574
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.97191924
3Mineral absorption_Homo sapiens_hsa049783.55229380
4Sulfur metabolism_Homo sapiens_hsa009203.31120755
5Ribosome_Homo sapiens_hsa030103.10372630
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82670692
7Complement and coagulation cascades_Homo sapiens_hsa046102.63810044
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59733309
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.55486376
10Folate biosynthesis_Homo sapiens_hsa007902.55324135
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.30021227
12Renin-angiotensin system_Homo sapiens_hsa046142.25360286
13Vitamin digestion and absorption_Homo sapiens_hsa049772.19837478
14Fructose and mannose metabolism_Homo sapiens_hsa000512.18547245
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17473969
16Oxidative phosphorylation_Homo sapiens_hsa001902.09137787
17Histidine metabolism_Homo sapiens_hsa003402.08146142
18Phenylalanine metabolism_Homo sapiens_hsa003602.02962965
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95438580
20Parkinsons disease_Homo sapiens_hsa050121.92911606
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86790230
22Galactose metabolism_Homo sapiens_hsa000521.80200706
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.79972772
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79489076
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75566593
26* Glutathione metabolism_Homo sapiens_hsa004801.75139448
27Protein digestion and absorption_Homo sapiens_hsa049741.73589752
28Tyrosine metabolism_Homo sapiens_hsa003501.64949401
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63260815
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.52250757
31Alzheimers disease_Homo sapiens_hsa050101.50801907
32Huntingtons disease_Homo sapiens_hsa050161.49508059
33Pentose phosphate pathway_Homo sapiens_hsa000301.41256044
34Tight junction_Homo sapiens_hsa045301.39372674
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37079334
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36247838
37Arginine and proline metabolism_Homo sapiens_hsa003301.30793881
38Bile secretion_Homo sapiens_hsa049761.30233413
39Chemical carcinogenesis_Homo sapiens_hsa052041.29284870
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26696756
41Tryptophan metabolism_Homo sapiens_hsa003801.21956385
42Starch and sucrose metabolism_Homo sapiens_hsa005001.20214936
43Linoleic acid metabolism_Homo sapiens_hsa005911.20109518
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16629115
45Fatty acid degradation_Homo sapiens_hsa000711.14752094
46Vitamin B6 metabolism_Homo sapiens_hsa007501.10428272
47Bladder cancer_Homo sapiens_hsa052191.10379497
48Peroxisome_Homo sapiens_hsa041461.08771233
49Staphylococcus aureus infection_Homo sapiens_hsa051501.08634658
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06133477
51Butanoate metabolism_Homo sapiens_hsa006501.00959028
52Glycerolipid metabolism_Homo sapiens_hsa005611.00067443
53Retinol metabolism_Homo sapiens_hsa008300.99353889
54Vibrio cholerae infection_Homo sapiens_hsa051100.98664730
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97623950
56Caffeine metabolism_Homo sapiens_hsa002320.96493236
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92023936
58Pancreatic secretion_Homo sapiens_hsa049720.91177998
59Proteasome_Homo sapiens_hsa030500.89396393
60Pyruvate metabolism_Homo sapiens_hsa006200.89393035
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.88574521
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.88125265
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86496982
64Fatty acid metabolism_Homo sapiens_hsa012120.86205654
65Protein export_Homo sapiens_hsa030600.82254336
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81474032
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79320160
68Carbon metabolism_Homo sapiens_hsa012000.79184208
69Hepatitis C_Homo sapiens_hsa051600.77705600
70Sphingolipid metabolism_Homo sapiens_hsa006000.77397173
71Fatty acid biosynthesis_Homo sapiens_hsa000610.74616201
72Thyroid cancer_Homo sapiens_hsa052160.72234092
73Pyrimidine metabolism_Homo sapiens_hsa002400.70796787
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67320599
75N-Glycan biosynthesis_Homo sapiens_hsa005100.63379337
76Nitrogen metabolism_Homo sapiens_hsa009100.62143148
77Metabolic pathways_Homo sapiens_hsa011000.61193061
78beta-Alanine metabolism_Homo sapiens_hsa004100.60984317
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58784007
80Adherens junction_Homo sapiens_hsa045200.57914665
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57410251
82Cardiac muscle contraction_Homo sapiens_hsa042600.56196098
83* Thyroid hormone synthesis_Homo sapiens_hsa049180.54062049
84Other glycan degradation_Homo sapiens_hsa005110.47424492
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.45033101
86Purine metabolism_Homo sapiens_hsa002300.44771591
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44299414
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42287079
89Propanoate metabolism_Homo sapiens_hsa006400.40745736
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40356515
91* Arachidonic acid metabolism_Homo sapiens_hsa005900.40054593
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.40034334
93Sulfur relay system_Homo sapiens_hsa041220.39302528
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.39068622
95Insulin resistance_Homo sapiens_hsa049310.37041096
96Salmonella infection_Homo sapiens_hsa051320.36975901
97Mismatch repair_Homo sapiens_hsa034300.36517176
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36186263
99Pertussis_Homo sapiens_hsa051330.35025030
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.34408544
101Ether lipid metabolism_Homo sapiens_hsa005650.32731259
102Legionellosis_Homo sapiens_hsa051340.32610701
103Arginine biosynthesis_Homo sapiens_hsa002200.32076378
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32050991
105Gastric acid secretion_Homo sapiens_hsa049710.31931962
106Selenocompound metabolism_Homo sapiens_hsa004500.31867277
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30876387
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29363285
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28465998
110p53 signaling pathway_Homo sapiens_hsa041150.28276309
111Prion diseases_Homo sapiens_hsa050200.28200586
112RNA polymerase_Homo sapiens_hsa030200.28074822
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26318343
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25094222
115PPAR signaling pathway_Homo sapiens_hsa033200.24558229
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24507519
117Biosynthesis of amino acids_Homo sapiens_hsa012300.22510540
118Influenza A_Homo sapiens_hsa051640.20735834
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19245614
120Fatty acid elongation_Homo sapiens_hsa000620.17450507
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16271682
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15995357
123Small cell lung cancer_Homo sapiens_hsa052220.14924865
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13074246
125ABC transporters_Homo sapiens_hsa020100.12355525
126Hippo signaling pathway_Homo sapiens_hsa043900.12185490
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.10368101
128Glucagon signaling pathway_Homo sapiens_hsa049220.09267370
129Ovarian steroidogenesis_Homo sapiens_hsa049130.06983023
130African trypanosomiasis_Homo sapiens_hsa051430.04147808
131Steroid biosynthesis_Homo sapiens_hsa001000.02402852
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.02249563

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