GPX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.02248031
2drug transmembrane transport (GO:0006855)7.74905546
3urate metabolic process (GO:0046415)7.30938953
4organic cation transport (GO:0015695)6.61194609
5drug transport (GO:0015893)6.42554944
6thyroid hormone generation (GO:0006590)6.09968573
7lysine metabolic process (GO:0006553)6.08795125
8lysine catabolic process (GO:0006554)6.08795125
9phosphate ion transport (GO:0006817)5.92292831
10positive regulation of respiratory burst (GO:0060267)5.75808963
11response to mercury ion (GO:0046689)5.71607438
12quaternary ammonium group transport (GO:0015697)5.70501003
13negative regulation of complement activation (GO:0045916)5.54178029
14thyroid hormone metabolic process (GO:0042403)5.46457895
15excretion (GO:0007588)5.17593116
16tricarboxylic acid metabolic process (GO:0072350)5.05436287
17vitamin D metabolic process (GO:0042359)4.88931321
18renal absorption (GO:0070293)4.87161761
19glyoxylate metabolic process (GO:0046487)4.84174146
20cysteine metabolic process (GO:0006534)4.81297088
21trivalent inorganic anion homeostasis (GO:0072506)4.59284837
22phosphate ion homeostasis (GO:0055062)4.59284837
23phosphate ion transmembrane transport (GO:0035435)4.55338188
24negative regulation of protein activation cascade (GO:2000258)4.52129573
25peptide catabolic process (GO:0043171)4.48768835
26toxin transport (GO:1901998)4.45486479
27glycoside metabolic process (GO:0016137)4.26834351
28nonribosomal peptide biosynthetic process (GO:0019184)4.26750673
29exogenous drug catabolic process (GO:0042738)4.23374592
30drug catabolic process (GO:0042737)4.23243391
31metanephric nephron tubule development (GO:0072234)4.19365210
32metanephric tubule development (GO:0072170)4.19365210
33amino-acid betaine transport (GO:0015838)4.09535724
34carnitine transport (GO:0015879)4.09535724
35branched-chain amino acid metabolic process (GO:0009081)4.04888497
36valine metabolic process (GO:0006573)4.03477150
37opsonization (GO:0008228)4.01265494
38short-chain fatty acid metabolic process (GO:0046459)3.96812020
39aspartate family amino acid catabolic process (GO:0009068)3.90912747
40metanephric nephron epithelium development (GO:0072243)3.85639694
41glutathione biosynthetic process (GO:0006750)3.84283409
42homocysteine metabolic process (GO:0050667)3.81178240
43L-phenylalanine metabolic process (GO:0006558)3.80346543
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80346543
45L-phenylalanine catabolic process (GO:0006559)3.78335027
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78335027
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.72339341
48ethanol oxidation (GO:0006069)3.67687192
49proline metabolic process (GO:0006560)3.64647706
50cellular response to vitamin D (GO:0071305)3.63018288
51metanephric epithelium development (GO:0072207)3.61424605
52negative regulation of humoral immune response (GO:0002921)3.58806352
53cellular modified amino acid catabolic process (GO:0042219)3.56727527
54fatty acid beta-oxidation (GO:0006635)3.50081896
55negative regulation of execution phase of apoptosis (GO:1900118)3.46533259
56regulation of fibrinolysis (GO:0051917)3.41749531
57modified amino acid transport (GO:0072337)3.39993452
58aromatic amino acid family catabolic process (GO:0009074)3.39862847
592-oxoglutarate metabolic process (GO:0006103)3.38918394
60response to parathyroid hormone (GO:0071107)3.36785842
61nephron tubule development (GO:0072080)3.32722737
62basement membrane organization (GO:0071711)3.30769068
63regulation of protein activation cascade (GO:2000257)3.30398682
64cellular response to vitamin (GO:0071295)3.28788357
65serine family amino acid catabolic process (GO:0009071)3.27916633
66negative regulation of metanephros development (GO:0072217)3.26177566
67fatty acid oxidation (GO:0019395)3.22405825
68regulation of extracellular matrix disassembly (GO:0010715)3.21929431
69branched-chain amino acid catabolic process (GO:0009083)3.18061603
70retinol metabolic process (GO:0042572)3.17859927
71protein carboxylation (GO:0018214)3.17007178
72peptidyl-glutamic acid carboxylation (GO:0017187)3.17007178
73transcytosis (GO:0045056)3.15889013
74positive regulation of digestive system process (GO:0060456)3.15514761
75keratan sulfate catabolic process (GO:0042340)3.14772563
76lipid oxidation (GO:0034440)3.14748470
77NADH metabolic process (GO:0006734)3.14313953
78beta-amyloid metabolic process (GO:0050435)3.14181424
79peptide biosynthetic process (GO:0043043)3.11893842
80nephron epithelium morphogenesis (GO:0072088)3.11325369
81nephron tubule morphogenesis (GO:0072078)3.11325369
82peptide hormone processing (GO:0016486)3.10801096
83regulation of sequestering of triglyceride (GO:0010889)3.10737569
84glucocorticoid biosynthetic process (GO:0006704)3.09255714
85pyrimidine ribonucleoside catabolic process (GO:0046133)3.08280063
86cellular ketone body metabolic process (GO:0046950)3.06597610
87fatty acid homeostasis (GO:0055089)3.06589685
88positive regulation of glycolytic process (GO:0045821)3.02819441
89potassium ion export (GO:0071435)3.01639861
90tryptophan catabolic process (GO:0006569)3.01048902
91indole-containing compound catabolic process (GO:0042436)3.01048902
92indolalkylamine catabolic process (GO:0046218)3.01048902
93fructose metabolic process (GO:0006000)2.99308945
94sulfur amino acid catabolic process (GO:0000098)2.97915553
95phenylpropanoid metabolic process (GO:0009698)2.97215848
96protein retention in ER lumen (GO:0006621)2.96177925
97triglyceride homeostasis (GO:0070328)2.95869161
98acylglycerol homeostasis (GO:0055090)2.95869161
99renal tubule development (GO:0061326)2.94778358
100amino-acid betaine metabolic process (GO:0006577)2.93852018
101blood coagulation, intrinsic pathway (GO:0007597)2.93476266
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92442223
103ethanol metabolic process (GO:0006067)2.92368267
104detection of calcium ion (GO:0005513)2.92270446
105tryptophan metabolic process (GO:0006568)2.89993510
106response to phenylpropanoid (GO:0080184)2.89246004
107response to growth hormone (GO:0060416)2.88953338
108detection of molecule of bacterial origin (GO:0032490)2.87160779
109oligosaccharide catabolic process (GO:0009313)2.87131234
110response to copper ion (GO:0046688)2.86574788
111glutathione metabolic process (GO:0006749)2.86298334
112primary alcohol metabolic process (GO:0034308)2.86288200
113complement activation, alternative pathway (GO:0006957)2.86264306
114regulation of guanylate cyclase activity (GO:0031282)2.84288560
115hormone catabolic process (GO:0042447)2.83149416
116low-density lipoprotein particle clearance (GO:0034383)2.81277605
117fatty acid catabolic process (GO:0009062)2.80325912
118triglyceride catabolic process (GO:0019433)2.78851186
119uronic acid metabolic process (GO:0006063)2.78408348
120glucuronate metabolic process (GO:0019585)2.78408348
121serine family amino acid metabolic process (GO:0009069)2.78262419
122surfactant homeostasis (GO:0043129)2.76782657
123regulation of type B pancreatic cell apoptotic process (GO:2000674)2.76602516
124response to dietary excess (GO:0002021)2.76129547
125renal tubule morphogenesis (GO:0061333)2.75736139
126tricarboxylic acid cycle (GO:0006099)2.75291105
127carnitine metabolic process (GO:0009437)2.75057532
128response to thyroid hormone (GO:0097066)2.74922438
129L-alpha-amino acid transmembrane transport (GO:1902475)2.74753496
130xenobiotic catabolic process (GO:0042178)2.73916150
131regulation of lipoprotein metabolic process (GO:0050746)2.72045164
132regulation of complement activation (GO:0030449)2.71553849
133acetyl-CoA metabolic process (GO:0006084)2.71415097
134macroautophagy (GO:0016236)2.70831560
135bone resorption (GO:0045453)2.70223529
136positive regulation of hormone metabolic process (GO:0032352)2.69405435
137ketone body metabolic process (GO:1902224)2.67016974
138glycerolipid catabolic process (GO:0046503)2.63092296
139toxin metabolic process (GO:0009404)2.62776184
140acylglycerol catabolic process (GO:0046464)2.61357144
141neutral lipid catabolic process (GO:0046461)2.61357144
142fatty acid transmembrane transport (GO:1902001)2.60960592
143glycerophospholipid catabolic process (GO:0046475)2.60746141
144regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55636245
145insulin secretion (GO:0030073)2.52999961
146carnitine shuttle (GO:0006853)2.51508552
147diacylglycerol metabolic process (GO:0046339)2.51048798
148regulation of execution phase of apoptosis (GO:1900117)2.49704390
149positive regulation of gluconeogenesis (GO:0045722)2.49364319
150positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.48271938
151regulation of energy homeostasis (GO:2000505)2.47501839
152nitric oxide biosynthetic process (GO:0006809)2.46810285
153negative regulation of hormone biosynthetic process (GO:0032353)2.46633901
154negative regulation of hormone metabolic process (GO:0032351)2.44858038
155phospholipid homeostasis (GO:0055091)2.43199221
156positive regulation of glomerulus development (GO:0090193)2.43080135
157cellular response to gonadotropin stimulus (GO:0071371)2.42561902
158lipid particle organization (GO:0034389)2.40764180
159regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40574839
160biotin metabolic process (GO:0006768)2.39797471
161reverse cholesterol transport (GO:0043691)2.38582996
162positive regulation of cellular amine metabolic process (GO:0033240)2.36453929
163lipid storage (GO:0019915)2.35343157
164phenol-containing compound catabolic process (GO:0019336)2.35152464
165plasma lipoprotein particle clearance (GO:0034381)2.35076130
166epoxygenase P450 pathway (GO:0019373)2.34839204
167regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.34270756
168ovulation from ovarian follicle (GO:0001542)2.34125909
169negative regulation of protein autophosphorylation (GO:0031953)2.33234549
170polyol transport (GO:0015791)2.32307336
171nitric oxide mediated signal transduction (GO:0007263)2.30833082
172hormone metabolic process (GO:0042445)2.30800353
173nephron tubule formation (GO:0072079)2.30368265
174positive regulation of insulin secretion (GO:0032024)2.29601730
175oxaloacetate metabolic process (GO:0006107)2.26965951
176pattern specification involved in kidney development (GO:0061004)2.26938882
177plasma lipoprotein particle remodeling (GO:0034369)2.26625868
178macromolecular complex remodeling (GO:0034367)2.26625868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.22011348
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.74977635
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.70493141
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.62467706
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.51804644
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.51043812
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21204375
8CLOCK_20551151_ChIP-Seq_293T_Human3.15324803
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88115674
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.82725818
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.52804317
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.51902558
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49771632
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42924022
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30966934
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11399224
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10738397
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89780454
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.78556498
20GBX2_23144817_ChIP-Seq_PC3_Human1.68120793
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61931910
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61855348
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54768459
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51653533
25GATA1_22025678_ChIP-Seq_K562_Human1.51125867
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50882131
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.50492092
28* SOX2_20726797_ChIP-Seq_SW620_Human1.49095248
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47280834
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47241149
31* TBX20_22080862_ChIP-Seq_HEART_Mouse1.46641059
32* TBX20_22328084_ChIP-Seq_HEART_Mouse1.46641059
33* LXR_22292898_ChIP-Seq_THP-1_Human1.46013687
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44342210
35RACK7_27058665_Chip-Seq_MCF-7_Human1.39963992
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36209258
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35573098
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35287348
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.34378630
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33229736
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31962992
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31951446
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29750708
44* BCAT_22108803_ChIP-Seq_LS180_Human1.26712946
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24613348
46HTT_18923047_ChIP-ChIP_STHdh_Human1.24530477
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24204675
48GATA4_25053715_ChIP-Seq_YYC3_Human1.23878062
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22366070
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20294150
51SMAD4_21799915_ChIP-Seq_A2780_Human1.19623339
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18939969
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17768110
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16687871
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15604998
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14474711
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.14387184
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14180566
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11823501
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11317453
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11225338
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.09393307
63CJUN_26792858_Chip-Seq_BT549_Human1.09006653
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07009386
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04787515
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04769800
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03086376
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02351842
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.02178071
70* CDX2_22108803_ChIP-Seq_LS180_Human1.01616132
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98083731
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97508498
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97508498
74CSB_26484114_Chip-Seq_FIBROBLAST_Human0.97253750
75* SMAD3_21741376_ChIP-Seq_HESCs_Human0.96489277
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95958569
77SMAD_19615063_ChIP-ChIP_OVARY_Human0.95916602
78HNF4A_19822575_ChIP-Seq_HepG2_Human0.94713377
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94555402
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94167314
81MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92708996
82EED_16625203_ChIP-ChIP_MESCs_Mouse0.92423949
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92009791
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91550386
85AR_25329375_ChIP-Seq_VCAP_Human0.91402810
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91302087
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91089139
88GATA3_24758297_ChIP-Seq_MCF-7_Human0.90098485
89* SMAD3_21741376_ChIP-Seq_EPCs_Human0.89044087
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88457628
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88400573
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87974554
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87837235
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85843909
95CBP_21632823_ChIP-Seq_H3396_Human0.85287826
96VDR_22108803_ChIP-Seq_LS180_Human0.85163513
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84934248
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84013544
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83533570
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83411815
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82899639
102* AHR_22903824_ChIP-Seq_MCF-7_Human0.82815387
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.82773360
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.82440403
105* ELK3_25401928_ChIP-Seq_HUVEC_Human0.82347213
106GATA6_25053715_ChIP-Seq_YYC3_Human0.81923428
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81847920
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.81673068
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81067597
110STAT3_23295773_ChIP-Seq_U87_Human0.81017009
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80876461
112SOX2_18555785_Chip-Seq_ESCs_Mouse0.80779519
113JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80708861
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80681794
115MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80629784
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.80616957
117* RAC3_21632823_ChIP-Seq_H3396_Human0.80364404
118* TCF4_22108803_ChIP-Seq_LS180_Human0.80170824
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80167040
120GATA1_19941826_ChIP-Seq_K562_Human0.79946641
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79936158
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79888606
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79602318
124* TP63_22573176_ChIP-Seq_HFKS_Human0.79272547
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79206691
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79080970
127* ARNT_22903824_ChIP-Seq_MCF-7_Human0.78351815
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77987737
129EGR1_19032775_ChIP-ChIP_M12_Human0.77849196
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77757013
131* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77719716
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77671606
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77394757
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.76987097
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76021284
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75779424
137KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74737389
138ATF3_27146783_Chip-Seq_COLON_Human0.74320948
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74305536
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73203282
141SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.72882755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.05166114
2MP0005360_urolithiasis4.89640808
3MP0003011_delayed_dark_adaptation4.28685139
4MP0004019_abnormal_vitamin_homeostasis4.12173773
5MP0001765_abnormal_ion_homeostasis3.85124136
6MP0005332_abnormal_amino_acid3.74102894
7MP0008438_abnormal_cutaneous_collagen3.57456026
8MP0009643_abnormal_urine_homeostasis3.50444238
9MP0003195_calcinosis3.50028273
10MP0009780_abnormal_chondrocyte_physiolo3.47267313
11MP0001958_emphysema3.44998699
12MP0001756_abnormal_urination3.18334991
13MP0002138_abnormal_hepatobiliary_system3.10288335
14MP0005058_abnormal_lysosome_morphology3.04853756
15MP0002139_abnormal_hepatobiliary_system3.04062958
16MP0010329_abnormal_lipoprotein_level2.85503730
17* MP0005636_abnormal_mineral_homeostasis2.81445744
18MP0002136_abnormal_kidney_physiology2.56413293
19MP0005379_endocrine/exocrine_gland_phen2.54883149
20MP0002837_dystrophic_cardiac_calcinosis2.44582132
21MP0006054_spinal_hemorrhage2.19876181
22MP0005377_hearing/vestibular/ear_phenot2.12347111
23MP0003878_abnormal_ear_physiology2.12347111
24MP0008875_abnormal_xenobiotic_pharmacok2.10938058
25MP0000013_abnormal_adipose_tissue2.06648969
26MP0002971_abnormal_brown_adipose2.02867115
27MP0003252_abnormal_bile_duct1.89192874
28MP0000538_abnormal_urinary_bladder1.88590256
29MP0002254_reproductive_system_inflammat1.87815241
30MP0003868_abnormal_feces_composition1.82207106
31MP0004272_abnormal_basement_membrane1.71644772
32MP0005365_abnormal_bile_salt1.68914856
33MP0001501_abnormal_sleep_pattern1.67605620
34MP0005645_abnormal_hypothalamus_physiol1.65536326
35MP0005670_abnormal_white_adipose1.59346230
36MP0003122_maternal_imprinting1.57113386
37MP0003879_abnormal_hair_cell1.55655919
38MP0005275_abnormal_skin_tensile1.54992400
39MP0000230_abnormal_systemic_arterial1.53993196
40MP0002693_abnormal_pancreas_physiology1.51637644
41MP0004215_abnormal_myocardial_fiber1.47980125
42MP0005448_abnormal_energy_balance1.45296682
43MP0004885_abnormal_endolymph1.44312520
44MP0008961_abnormal_basal_metabolism1.40430213
45MP0010386_abnormal_urinary_bladder1.37314880
46MP0002896_abnormal_bone_mineralization1.35848328
47MP0002168_other_aberrant_phenotype1.27214044
48MP0009840_abnormal_foam_cell1.25491606
49MP0004130_abnormal_muscle_cell1.25223653
50MP0003172_abnormal_lysosome_physiology1.24637815
51MP0004084_abnormal_cardiac_muscle1.23597017
52MP0005503_abnormal_tendon_morphology1.21569381
53MP0003300_gastrointestinal_ulcer1.21409798
54MP0004036_abnormal_muscle_relaxation1.19680774
55MP0005084_abnormal_gallbladder_morpholo1.17993060
56MP0003186_abnormal_redox_activity1.16149382
57MP0002638_abnormal_pupillary_reflex1.15899577
58MP0003279_aneurysm1.14428304
59MP0000604_amyloidosis1.11166801
60MP0002998_abnormal_bone_remodeling1.10774237
61MP0002135_abnormal_kidney_morphology1.10074227
62MP0003191_abnormal_cellular_cholesterol1.09623038
63MP0005167_abnormal_blood-brain_barrier1.08587729
64MP0005551_abnormal_eye_electrophysiolog1.08307092
65MP0003566_abnormal_cell_adhesion1.06766549
66MP0005253_abnormal_eye_physiology1.01842890
67MP0000003_abnormal_adipose_tissue1.01488414
68MP0005319_abnormal_enzyme/_coenzyme0.97593142
69MP0005085_abnormal_gallbladder_physiolo0.96629681
70MP0002972_abnormal_cardiac_muscle0.96421713
71MP0009115_abnormal_fat_cell0.96187561
72MP0002090_abnormal_vision0.94968637
73MP0005375_adipose_tissue_phenotype0.94892802
74MP0000639_abnormal_adrenal_gland0.94152465
75* MP0005584_abnormal_enzyme/coenzyme_acti0.92391814
76MP0006138_congestive_heart_failure0.91788411
77MP0004085_abnormal_heartbeat0.91071058
78MP0005666_abnormal_adipose_tissue0.91010053
79MP0001879_abnormal_lymphatic_vessel0.90581161
80MP0002163_abnormal_gland_morphology0.89236648
81MP0005452_abnormal_adipose_tissue0.88516988
82MP0001764_abnormal_homeostasis0.87804760
83MP0003690_abnormal_glial_cell0.87074776
84MP0001661_extended_life_span0.86624014
85MP0002876_abnormal_thyroid_physiology0.86487801
86MP0000678_abnormal_parathyroid_gland0.86410136
87MP0006072_abnormal_retinal_apoptosis0.86141626
88MP0003567_abnormal_fetal_cardiomyocyte0.86032708
89MP0001542_abnormal_bone_strength0.85478901
90MP0002115_abnormal_skeleton_extremities0.85180274
91MP0006036_abnormal_mitochondrial_physio0.83000773
92MP0002970_abnormal_white_adipose0.82277138
93MP0003795_abnormal_bone_structure0.81427241
94MP0002928_abnormal_bile_duct0.81164215
95MP0002089_abnormal_postnatal_growth/wei0.80869942
96MP0000681_abnormal_thyroid_gland0.79802547
97MP0005220_abnormal_exocrine_pancreas0.79564401
98MP0001666_abnormal_nutrient_absorption0.79005214
99MP0003075_altered_response_to0.78211313
100MP0004264_abnormal_extraembryonic_tissu0.78129563
101MP0003283_abnormal_digestive_organ0.77576613
102MP0008004_abnormal_stomach_pH0.76548946
103MP0005334_abnormal_fat_pad0.74996075
104MP0000163_abnormal_cartilage_morphology0.74002422
105MP0010234_abnormal_vibrissa_follicle0.73885429
106MP0005646_abnormal_pituitary_gland0.73008486
107MP0001664_abnormal_digestion0.73003917
108MP0003137_abnormal_impulse_conducting0.72582213
109MP0003638_abnormal_response/metabolism_0.72489352
110MP0009642_abnormal_blood_homeostasis0.71736917
111MP0005165_increased_susceptibility_to0.71710116
112MP0003183_abnormal_peptide_metabolism0.71399766
113MP0002909_abnormal_adrenal_gland0.70961896
114MP0002118_abnormal_lipid_homeostasis0.70823279
115MP0000609_abnormal_liver_physiology0.69724956
116MP0005164_abnormal_response_to0.69181936
117MP0005330_cardiomyopathy0.68854865
118MP0003705_abnormal_hypodermis_morpholog0.68371128
119MP0005385_cardiovascular_system_phenoty0.67474459
120MP0001544_abnormal_cardiovascular_syste0.67474459
121MP0008775_abnormal_heart_ventricle0.67058566
122MP0004484_altered_response_of0.66856553
123MP0000534_abnormal_ureter_morphology0.66314612
124MP0001984_abnormal_olfaction0.65833626
125MP0009764_decreased_sensitivity_to0.65655185
126MP0003959_abnormal_lean_body0.65477195
127MP0000747_muscle_weakness0.65421547
128MP0001270_distended_abdomen0.63571904
129MP0001944_abnormal_pancreas_morphology0.63437885
130MP0002078_abnormal_glucose_homeostasis0.62832460
131MP0004858_abnormal_nervous_system0.62797129
132MP0005535_abnormal_body_temperature0.62661312
133MP0002269_muscular_atrophy0.62598135
134MP0000749_muscle_degeneration0.62391276
135MP0003329_amyloid_beta_deposits0.62255735
136MP0000751_myopathy0.62177956
137MP0010368_abnormal_lymphatic_system0.61839822
138MP0000343_altered_response_to0.61456712
139MP0002295_abnormal_pulmonary_circulatio0.58781031
140MP0003953_abnormal_hormone_level0.58392154
141MP0005451_abnormal_body_composition0.57714796

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.44164809
2Metabolic alkalosis (HP:0200114)6.42670183
3Hypokalemic alkalosis (HP:0001949)6.25882537
4Hyperactive renin-angiotensin system (HP:0000841)6.12552058
5Gout (HP:0001997)5.78937286
6Abnormality of chloride homeostasis (HP:0011422)5.73880933
7Polyuria (HP:0000103)5.69920810
8Hypomagnesemia (HP:0002917)5.50541978
9Abnormal urine output (HP:0012590)5.39973580
10Abnormality of renal excretion (HP:0011036)5.12404406
11Abnormality of renin-angiotensin system (HP:0000847)4.81365128
12Abnormality of magnesium homeostasis (HP:0004921)4.77834211
13Proximal tubulopathy (HP:0000114)4.71816663
14Abnormal drinking behavior (HP:0030082)4.60561229
15Polydipsia (HP:0001959)4.60561229
16Goiter (HP:0000853)4.51308804
17Hyperaldosteronism (HP:0000859)4.48719258
18Renal salt wasting (HP:0000127)4.37805824
19Increased purine levels (HP:0004368)4.30460750
20Hyperuricemia (HP:0002149)4.30460750
21Alkalosis (HP:0001948)4.24453055
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04237254
23Complement deficiency (HP:0004431)4.04212499
24Tetany (HP:0001281)4.01304532
25Abnormality of purine metabolism (HP:0004352)3.99244049
26Hypokalemia (HP:0002900)3.96281728
27Hypothermia (HP:0002045)3.83830040
28Generalized aminoaciduria (HP:0002909)3.82779653
29Hyperglycinuria (HP:0003108)3.67318848
30Prolonged partial thromboplastin time (HP:0003645)3.59012055
31Hyperglycemia (HP:0003074)3.57419710
32Hypercalciuria (HP:0002150)3.50502428
33Ketoacidosis (HP:0001993)3.49214684
34Hydroxyprolinuria (HP:0003080)3.44879820
35Abnormality of proline metabolism (HP:0010907)3.44879820
36Vacuolated lymphocytes (HP:0001922)3.42563274
37Increased CSF protein (HP:0002922)3.32393260
38Thyroid-stimulating hormone excess (HP:0002925)3.30082338
39Congenital sensorineural hearing impairment (HP:0008527)3.28016634
40Abnormality of potassium homeostasis (HP:0011042)3.27703531
41Decreased circulating renin level (HP:0003351)3.22408046
42Xanthomatosis (HP:0000991)3.12523104
43Glycosuria (HP:0003076)3.08473155
44Abnormality of urine glucose concentration (HP:0011016)3.08473155
45Hyperthyroidism (HP:0000836)3.08088243
46Abnormality of complement system (HP:0005339)3.04981367
47Renal tubular acidosis (HP:0001947)2.96647071
48Dysostosis multiplex (HP:0000943)2.96257409
49Glomerulonephritis (HP:0000099)2.94269924
50Joint hemorrhage (HP:0005261)2.91460399
51Congenital malformation of the right heart (HP:0011723)2.89117053
52Double outlet right ventricle (HP:0001719)2.89117053
53Insulin-resistant diabetes mellitus (HP:0000831)2.81067858
54Ketosis (HP:0001946)2.77498803
55Abnormality of serine family amino acid metabolism (HP:0010894)2.76878881
56Abnormality of glycine metabolism (HP:0010895)2.76878881
57Urinary glycosaminoglycan excretion (HP:0003541)2.75788306
58Mucopolysacchariduria (HP:0008155)2.75788306
59Large for gestational age (HP:0001520)2.69581248
60Spondylolisthesis (HP:0003302)2.68170821
61Hyperlipoproteinemia (HP:0010980)2.68122322
62Abnormality of nucleobase metabolism (HP:0010932)2.67988181
63Systemic lupus erythematosus (HP:0002725)2.66145272
64Hyperphosphaturia (HP:0003109)2.64703762
65Nephrolithiasis (HP:0000787)2.56923310
66Abnormality of polysaccharide metabolism (HP:0011012)2.56489491
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56489491
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56489491
69Abnormality of sodium homeostasis (HP:0010931)2.54733417
70Abnormality of vitamin metabolism (HP:0100508)2.54089790
71Oligomenorrhea (HP:0000876)2.48607625
72Malnutrition (HP:0004395)2.48496003
73Delayed epiphyseal ossification (HP:0002663)2.47195657
74Abnormal urine phosphate concentration (HP:0012599)2.47009066
75Nephrocalcinosis (HP:0000121)2.46158785
76Deep venous thrombosis (HP:0002625)2.44594027
77Hypoglycemic seizures (HP:0002173)2.44546857
78Syncope (HP:0001279)2.44384566
79Persistence of primary teeth (HP:0006335)2.43558531
80Abnormality of fatty-acid metabolism (HP:0004359)2.42373200
81Hypophosphatemia (HP:0002148)2.41273764
82Hyperinsulinemic hypoglycemia (HP:0000825)2.38901777
83Mitral stenosis (HP:0001718)2.37854952
84Adrenal overactivity (HP:0002717)2.36729350
85Hyponatremia (HP:0002902)2.34844898
86Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34492807
87Metaphyseal cupping (HP:0003021)2.32000361
88Thin bony cortex (HP:0002753)2.31983338
89Premature rupture of membranes (HP:0001788)2.29201551
90Hypobetalipoproteinemia (HP:0003563)2.25089675
91Cervical subluxation (HP:0003308)2.21581960
92Hypoglycemic coma (HP:0001325)2.21127312
93Insulin resistance (HP:0000855)2.19849014
94Chondrocalcinosis (HP:0000934)2.18899643
95Skin nodule (HP:0200036)2.15703701
96Abnormality of vitamin B metabolism (HP:0004340)2.14979686
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13802889
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12981883
99Epidermoid cyst (HP:0200040)2.11171181
100Asymmetric septal hypertrophy (HP:0001670)2.10793380
101Intestinal atresia (HP:0011100)2.10389987
102Widely patent fontanelles and sutures (HP:0004492)2.07452733
103Prolonged QT interval (HP:0001657)2.07107857
104Aortic dissection (HP:0002647)2.06772303
105Vomiting (HP:0002013)2.03875446
106Abnormality of calcium-phosphate metabolism (HP:0100530)2.03304089
107Vascular calcification (HP:0004934)2.03235729
108Abnormality of Sharpey fibers (HP:0100685)2.02385974
109Striae distensae (HP:0001065)2.01672962
110Rickets (HP:0002748)2.01577340
111Nuclear cataract (HP:0100018)2.01130270
112Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.00310702
113Growth hormone excess (HP:0000845)2.00304186
114Dehydration (HP:0001944)2.00000334
115Enlarged penis (HP:0000040)1.98880174
116Progressive neurologic deterioration (HP:0002344)1.98290590
117Postural tremor (HP:0002174)1.97339261
118Palpitations (HP:0001962)1.96709846
119Aortic aneurysm (HP:0004942)1.96563750
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96329391
121Cardiovascular calcification (HP:0011915)1.95383034
122Hypolipoproteinemia (HP:0010981)1.95320585
123Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93572176
124Pigmentary retinal degeneration (HP:0001146)1.93523948
125Atrial fibrillation (HP:0005110)1.92190415
126Bradycardia (HP:0001662)1.91594961
127Nausea (HP:0002018)1.89206496
128Abnormal EKG (HP:0003115)1.88441530
129Hypoalphalipoproteinemia (HP:0003233)1.88095008
130Hyperkalemia (HP:0002153)1.87871755
131Arterial tortuosity (HP:0005116)1.87633206
132Abnormality of renal resorption (HP:0011038)1.87052985
133Thyroid carcinoma (HP:0002890)1.86810208
134Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86753354
135Tubulointerstitial fibrosis (HP:0005576)1.85932565
136Enlarged kidneys (HP:0000105)1.84917304
137Lymphangioma (HP:0100764)1.83857575
138Acanthosis nigricans (HP:0000956)1.83093900
139Late onset (HP:0003584)1.83057767
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82938607
141Dicarboxylic aciduria (HP:0003215)1.82938607
142Testicular neoplasm (HP:0010788)1.81718227
143Bundle branch block (HP:0011710)1.81641159
144Axonal loss (HP:0003447)1.81471808
145Bone cyst (HP:0012062)1.80376089
146Hypokinesia (HP:0002375)1.79743644
147Cerebral aneurysm (HP:0004944)1.79134049
148Hypotension (HP:0002615)1.78770287
149Abnormal enzyme/coenzyme activity (HP:0012379)1.78067358
150Vascular tortuosity (HP:0004948)1.77195759
151Hyperammonemia (HP:0001987)1.76082142
152Facial shape deformation (HP:0011334)1.75278443
153Potter facies (HP:0002009)1.75278443
154Abnormality of alkaline phosphatase activity (HP:0004379)1.75041621
155Metabolic acidosis (HP:0001942)1.73182005
156Hyperglycinemia (HP:0002154)1.72557580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.08376095
2WNK37.62451494
3OXSR14.91018432
4GRK13.09381386
5STK392.99211676
6PHKG22.77717908
7PHKG12.77717908
8TGFBR22.69720498
9MAPK152.49367646
10MYLK2.40464543
11BCKDK2.33155244
12STK38L2.31232371
13PIK3CG2.28352918
14ERN12.23970553
15FGFR32.13463057
16MAP2K62.00958034
17FGFR21.95099577
18WNK11.82607135
19NLK1.77866145
20DAPK21.64046560
21AKT31.60649451
22PDK21.56478482
23SGK2231.44364781
24SGK4941.44364781
25NTRK31.42884200
26STK241.41071328
27TRIB31.40629541
28PDK41.36164051
29PDK31.36164051
30PRKCE1.36055652
31MAP4K21.33773177
32INSRR1.30844980
33MST1R1.25332398
34STK381.25309972
35TTN1.24955986
36FGFR41.22866218
37TIE11.21390938
38EPHB11.19826485
39CAMK2D1.17981203
40PDGFRA1.14376860
41FRK1.07901446
42PAK40.98400279
43STK30.96962054
44HIPK20.95897718
45FER0.94035475
46LRRK20.93231531
47PTK20.91641626
48MAP3K120.90448273
49NEK10.88636223
50MAP3K30.88301922
51MAPKAPK30.82755723
52ADRBK20.82221384
53UHMK10.82098588
54PTK60.78985798
55GSK3A0.78208039
56PRKD30.77095812
57YES10.73333908
58TESK10.72612968
59EPHA20.71976948
60PAK30.71916929
61MAP3K40.70486197
62TAOK30.70035207
63EPHB20.68124777
64MET0.67883156
65DYRK1B0.67833480
66PDPK10.66095423
67RIPK10.65057013
68CAMK10.64026394
69CSNK1G10.62924888
70MAP3K20.62457543
71SGK30.62342094
72PRKACG0.60740356
73EPHA30.58429647
74MAP3K70.58249402
75MAP3K60.57406531
76PRKG10.56816198
77PRKCG0.54793187
78SGK20.53803790
79NTRK10.52687778
80JAK10.51750573
81PRKD20.50689036
82PRKACA0.50498882
83LATS10.49999853
84AKT20.49710296
85STK40.49161999
86PINK10.48739488
87ADRBK10.48661419
88DDR20.48523663
89PTK2B0.48006518
90NEK90.46538985
91CAMK2G0.45298966
92IRAK10.45292407
93PIK3CA0.44802949
94ROCK10.44432046
95OBSCN0.43798369
96CDC42BPA0.43530800
97PRKACB0.43527352
98KDR0.41815487
99PAK20.40649318
100CSNK1G20.40090921
101MAP2K20.39935821
102PRKCH0.39932298
103IRAK30.39632902
104CSNK1A10.37718028
105SGK10.37661979
106BMX0.37159588
107MAP2K30.36933973
108ABL20.35894860
109MST40.35790251
110LIMK10.34263595
111RET0.34201148
112PRKAA10.34192977
113CAMK2A0.33392070
114MAPK120.33061682
115DMPK0.32590714
116PKN20.30786159
117PDK10.30492159
118CSK0.30161666
119LMTK20.27980760
120MAP3K10.25793134
121PRKAA20.25562679
122MARK30.23177073
123PRKD10.23054199
124MTOR0.22967013
125PRKCI0.22413742
126FGFR10.21934311
127MAP2K10.21732892
128DAPK30.20978516
129SCYL20.19343703
130ILK0.18719222
131PRKG20.18152660
132SRC0.16908188
133ROCK20.16502587
134KSR20.16419558
135SIK10.15813477
136MAP3K100.15356513
137TRPM70.14899994
138JAK20.14635242
139MAPK110.14265959
140ZAP700.13750673

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.46924224
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.97333703
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95895549
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74593934
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71060216
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.68243596
7Butanoate metabolism_Homo sapiens_hsa006502.66335367
8Propanoate metabolism_Homo sapiens_hsa006402.62440066
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56815475
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.51991781
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40310929
12Other glycan degradation_Homo sapiens_hsa005112.37780166
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33023886
14Fatty acid degradation_Homo sapiens_hsa000712.17956729
15Collecting duct acid secretion_Homo sapiens_hsa049662.15343574
16Tryptophan metabolism_Homo sapiens_hsa003802.10964880
17Pyruvate metabolism_Homo sapiens_hsa006202.03518995
18Peroxisome_Homo sapiens_hsa041461.99501981
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99488525
20Sulfur metabolism_Homo sapiens_hsa009201.85814398
21Vitamin B6 metabolism_Homo sapiens_hsa007501.79409110
22Lysosome_Homo sapiens_hsa041421.77323367
23Vitamin digestion and absorption_Homo sapiens_hsa049771.74497679
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.73780149
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58030707
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.55169083
27Fatty acid metabolism_Homo sapiens_hsa012121.52755160
28Carbon metabolism_Homo sapiens_hsa012001.52551003
29Protein digestion and absorption_Homo sapiens_hsa049741.50309416
30beta-Alanine metabolism_Homo sapiens_hsa004101.44723704
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40603097
32Arginine and proline metabolism_Homo sapiens_hsa003301.39679622
33Bile secretion_Homo sapiens_hsa049761.38467341
34Nitrogen metabolism_Homo sapiens_hsa009101.36871898
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34705629
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33310462
37PPAR signaling pathway_Homo sapiens_hsa033201.30459559
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29916905
39Starch and sucrose metabolism_Homo sapiens_hsa005001.28479728
40* Glutathione metabolism_Homo sapiens_hsa004801.22968902
41Circadian rhythm_Homo sapiens_hsa047101.22267211
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20387474
43Fatty acid biosynthesis_Homo sapiens_hsa000611.20077804
44Fat digestion and absorption_Homo sapiens_hsa049751.17378513
45Lysine degradation_Homo sapiens_hsa003101.16066422
46Mineral absorption_Homo sapiens_hsa049781.15659645
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08876988
48Histidine metabolism_Homo sapiens_hsa003401.08398639
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98914004
50Phototransduction_Homo sapiens_hsa047440.91551287
51Renin secretion_Homo sapiens_hsa049240.91471814
52Vibrio cholerae infection_Homo sapiens_hsa051100.89457183
53Renin-angiotensin system_Homo sapiens_hsa046140.81603842
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80360630
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.79890995
56Pentose phosphate pathway_Homo sapiens_hsa000300.78462930
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77382644
58Arginine biosynthesis_Homo sapiens_hsa002200.77249985
59Phenylalanine metabolism_Homo sapiens_hsa003600.76982381
60Sphingolipid metabolism_Homo sapiens_hsa006000.75526988
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75375216
62Protein export_Homo sapiens_hsa030600.74870488
63Ovarian steroidogenesis_Homo sapiens_hsa049130.74773201
64Ether lipid metabolism_Homo sapiens_hsa005650.74202523
65Fructose and mannose metabolism_Homo sapiens_hsa000510.74126395
66Glycerolipid metabolism_Homo sapiens_hsa005610.73959250
67Linoleic acid metabolism_Homo sapiens_hsa005910.73882476
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72802956
69Folate biosynthesis_Homo sapiens_hsa007900.72331757
70Oxidative phosphorylation_Homo sapiens_hsa001900.71283734
71ECM-receptor interaction_Homo sapiens_hsa045120.68707363
72Biosynthesis of amino acids_Homo sapiens_hsa012300.66472249
73Selenocompound metabolism_Homo sapiens_hsa004500.63780224
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61639798
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60788933
76Caffeine metabolism_Homo sapiens_hsa002320.59895628
77* Thyroid hormone synthesis_Homo sapiens_hsa049180.58524575
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.58494992
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.56150078
80Complement and coagulation cascades_Homo sapiens_hsa046100.55417921
81Rheumatoid arthritis_Homo sapiens_hsa053230.54229034
82AMPK signaling pathway_Homo sapiens_hsa041520.53766963
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51950582
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48107613
85Galactose metabolism_Homo sapiens_hsa000520.45564865
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45041456
87Fatty acid elongation_Homo sapiens_hsa000620.44667610
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.44589045
89Metabolic pathways_Homo sapiens_hsa011000.44117352
90Gastric acid secretion_Homo sapiens_hsa049710.43470000
91Chemical carcinogenesis_Homo sapiens_hsa052040.43187892
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42872116
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41893123
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41516986
95Focal adhesion_Homo sapiens_hsa045100.40620829
96ABC transporters_Homo sapiens_hsa020100.40084895
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38759437
98Type II diabetes mellitus_Homo sapiens_hsa049300.38757413
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37766034
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36826476
101Phagosome_Homo sapiens_hsa041450.35382179
102Dilated cardiomyopathy_Homo sapiens_hsa054140.35129343
103GABAergic synapse_Homo sapiens_hsa047270.34747559
104Cardiac muscle contraction_Homo sapiens_hsa042600.34119333
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33613889
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33485536
107* Arachidonic acid metabolism_Homo sapiens_hsa005900.31858687
108Parkinsons disease_Homo sapiens_hsa050120.31657582
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28471805
110Regulation of autophagy_Homo sapiens_hsa041400.27755667
111Amoebiasis_Homo sapiens_hsa051460.27568855
112Retinol metabolism_Homo sapiens_hsa008300.25453540
113Insulin resistance_Homo sapiens_hsa049310.23600956
114Glucagon signaling pathway_Homo sapiens_hsa049220.21181169
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18297462
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17706869
117Insulin secretion_Homo sapiens_hsa049110.17642162
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16623116
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.16461555
120Tyrosine metabolism_Homo sapiens_hsa003500.16311716
121Synaptic vesicle cycle_Homo sapiens_hsa047210.15408210
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15091539
123Alzheimers disease_Homo sapiens_hsa050100.14584269
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.14434987

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