Rank | Gene Set | Z-score |
---|---|---|
1 | cell wall macromolecule metabolic process (GO:0044036) | 6.60326143 |
2 | cell wall macromolecule catabolic process (GO:0016998) | 6.60326143 |
3 | fusion of sperm to egg plasma membrane (GO:0007342) | 5.53051778 |
4 | sequestering of actin monomers (GO:0042989) | 5.47865263 |
5 | tricarboxylic acid cycle (GO:0006099) | 5.26642039 |
6 | protein maturation by protein folding (GO:0022417) | 5.05506937 |
7 | sperm-egg recognition (GO:0035036) | 5.04376669 |
8 | binding of sperm to zona pellucida (GO:0007339) | 4.79786760 |
9 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.74915498 |
10 | sperm motility (GO:0030317) | 4.69796256 |
11 | organic cation transport (GO:0015695) | 4.69646823 |
12 | acrosome reaction (GO:0007340) | 4.60680869 |
13 | oxidative phosphorylation (GO:0006119) | 4.46698452 |
14 | cell-cell recognition (GO:0009988) | 4.41874788 |
15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.40122146 |
16 | ATP synthesis coupled proton transport (GO:0015986) | 4.40122146 |
17 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.33846325 |
18 | NADH metabolic process (GO:0006734) | 4.24369763 |
19 | plasma membrane fusion (GO:0045026) | 4.17031448 |
20 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.16863196 |
21 | L-phenylalanine catabolic process (GO:0006559) | 4.16863196 |
22 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.16708886 |
23 | respiratory electron transport chain (GO:0022904) | 4.11669905 |
24 | electron transport chain (GO:0022900) | 4.06814741 |
25 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.06419315 |
26 | carnitine transport (GO:0015879) | 4.05954258 |
27 | amino-acid betaine transport (GO:0015838) | 4.05954258 |
28 | acrosome assembly (GO:0001675) | 3.98379058 |
29 | regulation of cholesterol esterification (GO:0010872) | 3.89009833 |
30 | lysine metabolic process (GO:0006553) | 3.82136663 |
31 | lysine catabolic process (GO:0006554) | 3.82136663 |
32 | carnitine transmembrane transport (GO:1902603) | 3.73819888 |
33 | multicellular organism reproduction (GO:0032504) | 3.72203580 |
34 | aspartate family amino acid catabolic process (GO:0009068) | 3.70244617 |
35 | spermatid development (GO:0007286) | 3.67203666 |
36 | triglyceride catabolic process (GO:0019433) | 3.66270901 |
37 | ATP biosynthetic process (GO:0006754) | 3.62400541 |
38 | quaternary ammonium group transport (GO:0015697) | 3.59122012 |
39 | neutral lipid catabolic process (GO:0046461) | 3.57585594 |
40 | acylglycerol catabolic process (GO:0046464) | 3.57585594 |
41 | fatty acid beta-oxidation (GO:0006635) | 3.53175364 |
42 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.52697661 |
43 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.52697661 |
44 | motile cilium assembly (GO:0044458) | 3.47997016 |
45 | proline biosynthetic process (GO:0006561) | 3.43106690 |
46 | reproduction (GO:0000003) | 3.42130485 |
47 | response to mercury ion (GO:0046689) | 3.39862063 |
48 | plasma lipoprotein particle clearance (GO:0034381) | 3.37709334 |
49 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.36861739 |
50 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.31617723 |
51 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.30175078 |
52 | chaperone-mediated protein complex assembly (GO:0051131) | 3.29910807 |
53 | GDP-mannose metabolic process (GO:0019673) | 3.29899788 |
54 | oxaloacetate metabolic process (GO:0006107) | 3.26933049 |
55 | low-density lipoprotein particle clearance (GO:0034383) | 3.26848888 |
56 | branched-chain amino acid catabolic process (GO:0009083) | 3.26686829 |
57 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.23155736 |
58 | hydrogen ion transmembrane transport (GO:1902600) | 3.22363449 |
59 | ADP metabolic process (GO:0046031) | 3.20818034 |
60 | alditol metabolic process (GO:0019400) | 3.20814007 |
61 | glucose catabolic process (GO:0006007) | 3.18609692 |
62 | Golgi transport vesicle coating (GO:0048200) | 3.18265766 |
63 | COPI coating of Golgi vesicle (GO:0048205) | 3.18265766 |
64 | tricarboxylic acid metabolic process (GO:0072350) | 3.17327230 |
65 | sperm capacitation (GO:0048240) | 3.16343680 |
66 | valine metabolic process (GO:0006573) | 3.15951956 |
67 | carnitine shuttle (GO:0006853) | 3.11639010 |
68 | acetyl-CoA metabolic process (GO:0006084) | 3.11145729 |
69 | fatty acid catabolic process (GO:0009062) | 3.09810869 |
70 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.09006034 |
71 | 2-oxoglutarate metabolic process (GO:0006103) | 3.08913601 |
72 | protein retention in ER lumen (GO:0006621) | 3.08383428 |
73 | branched-chain amino acid metabolic process (GO:0009081) | 3.08137621 |
74 | protein carboxylation (GO:0018214) | 3.06287750 |
75 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.06287750 |
76 | carnitine metabolic process (GO:0009437) | 3.02220795 |
77 | fatty acid oxidation (GO:0019395) | 3.01475536 |
78 | fatty acid transmembrane transport (GO:1902001) | 3.01349257 |
79 | barbed-end actin filament capping (GO:0051016) | 3.00997022 |
80 | pentose metabolic process (GO:0019321) | 2.99936858 |
81 | succinate metabolic process (GO:0006105) | 2.99055218 |
82 | lipid particle organization (GO:0034389) | 2.99037107 |
83 | DNA deamination (GO:0045006) | 2.98580055 |
84 | synaptonemal complex organization (GO:0070193) | 2.97484275 |
85 | ribosomal small subunit biogenesis (GO:0042274) | 2.97374306 |
86 | synaptonemal complex assembly (GO:0007130) | 2.96955429 |
87 | NADPH regeneration (GO:0006740) | 2.96770166 |
88 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.96443235 |
89 | chaperone-mediated protein transport (GO:0072321) | 2.95943707 |
90 | lipid oxidation (GO:0034440) | 2.95794071 |
91 | axonemal dynein complex assembly (GO:0070286) | 2.94698357 |
92 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.94256750 |
93 | regulation of cilium movement (GO:0003352) | 2.87670278 |
94 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.87283540 |
95 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.87283540 |
96 | regulation of mitochondrial translation (GO:0070129) | 2.86972174 |
97 | epithelial cilium movement (GO:0003351) | 2.84838566 |
98 | extracellular fibril organization (GO:0043206) | 2.82960926 |
99 | aldehyde catabolic process (GO:0046185) | 2.82202045 |
100 | regulation of sequestering of triglyceride (GO:0010889) | 2.82057139 |
101 | fructose metabolic process (GO:0006000) | 2.81083311 |
102 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.80802404 |
103 | polyketide metabolic process (GO:0030638) | 2.79322701 |
104 | doxorubicin metabolic process (GO:0044598) | 2.79322701 |
105 | daunorubicin metabolic process (GO:0044597) | 2.79322701 |
106 | glycerolipid catabolic process (GO:0046503) | 2.78581593 |
107 | regulation of cholesterol storage (GO:0010885) | 2.78193980 |
108 | monosaccharide biosynthetic process (GO:0046364) | 2.77986801 |
109 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.77792961 |
110 | alpha-linolenic acid metabolic process (GO:0036109) | 2.76648507 |
111 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.76007955 |
112 | hexose biosynthetic process (GO:0019319) | 2.75857510 |
113 | proline metabolic process (GO:0006560) | 2.75605831 |
114 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.75254943 |
115 | UV protection (GO:0009650) | 2.73946087 |
116 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.73114683 |
117 | fatty acid homeostasis (GO:0055089) | 2.71852207 |
118 | glycerol metabolic process (GO:0006071) | 2.71804365 |
119 | biotin metabolic process (GO:0006768) | 2.70908307 |
120 | glycolytic process (GO:0006096) | 2.69553699 |
121 | cysteine metabolic process (GO:0006534) | 2.69446496 |
122 | L-ascorbic acid metabolic process (GO:0019852) | 2.68570576 |
123 | proton transport (GO:0015992) | 2.67955453 |
124 | amino-acid betaine metabolic process (GO:0006577) | 2.67230651 |
125 | gluconeogenesis (GO:0006094) | 2.67161847 |
126 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.66976330 |
127 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.66858516 |
128 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.66858516 |
129 | ribonucleoside monophosphate biosynthetic process (GO:0009156) | 2.66595585 |
130 | hydrogen transport (GO:0006818) | 2.66309808 |
131 | ethanol oxidation (GO:0006069) | 2.64856516 |
132 | heme biosynthetic process (GO:0006783) | 2.64653635 |
133 | pentose-phosphate shunt (GO:0006098) | 2.64428527 |
134 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176) | 2.63840138 |
135 | mitochondrial fusion (GO:0008053) | 2.62992823 |
136 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.62913253 |
137 | L-phenylalanine metabolic process (GO:0006558) | 2.62913253 |
138 | positive regulation of cellular amine metabolic process (GO:0033240) | 2.62761407 |
139 | regulation of oxidative phosphorylation (GO:0002082) | 2.61957816 |
140 | glyoxylate metabolic process (GO:0046487) | 2.61354386 |
141 | nitrogen cycle metabolic process (GO:0071941) | 2.60059242 |
142 | single fertilization (GO:0007338) | 2.59597321 |
143 | monocarboxylic acid catabolic process (GO:0072329) | 2.59588886 |
144 | mitochondrial transport (GO:0006839) | 2.59134089 |
145 | protein targeting to mitochondrion (GO:0006626) | 2.58420198 |
146 | CDP-diacylglycerol metabolic process (GO:0046341) | 2.57380753 |
147 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 2.57296781 |
148 | urea cycle (GO:0000050) | 2.57277036 |
149 | NADP metabolic process (GO:0006739) | 2.57262473 |
150 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.54996744 |
151 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.54996744 |
152 | nucleoside diphosphate biosynthetic process (GO:0009133) | 2.53685256 |
153 | GTP biosynthetic process (GO:0006183) | 2.50191025 |
154 | regulation of sterol transport (GO:0032371) | 2.46083175 |
155 | regulation of cholesterol transport (GO:0032374) | 2.46083175 |
156 | heme metabolic process (GO:0042168) | 2.45544952 |
157 | endoplasmic reticulum calcium ion homeostasis (GO:0032469) | 2.45209780 |
158 | urea metabolic process (GO:0019627) | 2.44527231 |
159 | viral transcription (GO:0019083) | 2.43714027 |
160 | * hydrogen peroxide catabolic process (GO:0042744) | 2.42895563 |
161 | primary alcohol catabolic process (GO:0034310) | 2.42684812 |
162 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 2.41889916 |
163 | blood coagulation, intrinsic pathway (GO:0007597) | 2.40597723 |
164 | aminoglycoside antibiotic metabolic process (GO:0030647) | 2.40090789 |
165 | nuclear envelope reassembly (GO:0031468) | 2.39314251 |
166 | mitotic nuclear envelope reassembly (GO:0007084) | 2.39314251 |
167 | pinocytosis (GO:0006907) | 2.38374134 |
168 | fibril organization (GO:0097435) | 2.37828811 |
169 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.37750578 |
170 | establishment of protein localization to mitochondrion (GO:0072655) | 2.36472713 |
171 | protein complex biogenesis (GO:0070271) | 2.35684668 |
172 | cyclooxygenase pathway (GO:0019371) | 2.35382544 |
173 | UTP biosynthetic process (GO:0006228) | 2.33085624 |
174 | regulation of mitochondrial membrane potential (GO:0051881) | 2.32850712 |
175 | glutathione biosynthetic process (GO:0006750) | 2.31761392 |
176 | diacylglycerol metabolic process (GO:0046339) | 2.31433995 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.20546318 |
2 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.20857635 |
3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.44713805 |
4 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.01274376 |
5 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.88586513 |
6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.84383871 |
7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.54755542 |
8 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.45401369 |
9 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.39931339 |
10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.38696218 |
11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.37515757 |
12 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 2.37394265 |
13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.18445176 |
14 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.14441601 |
15 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.14428581 |
16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.13031574 |
17 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.08015098 |
18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.04898912 |
19 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.00315009 |
20 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.93000440 |
21 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.91863827 |
22 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.87830388 |
23 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.86080996 |
24 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.84670923 |
25 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.82091881 |
26 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.77351604 |
27 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.75727926 |
28 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.69685347 |
29 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.67753764 |
30 | * VDR_21846776_ChIP-Seq_THP-1_Human | 1.67220826 |
31 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.65905323 |
32 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.62574997 |
33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.62570833 |
34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.62275012 |
35 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.62165447 |
36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.56097461 |
37 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.55363852 |
38 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.54953143 |
39 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.54756676 |
40 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.52559293 |
41 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.52558952 |
42 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.52490407 |
43 | * SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.52125242 |
44 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.51541684 |
45 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.45911835 |
46 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.45108033 |
47 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.41018480 |
48 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.36823803 |
49 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.35822401 |
50 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.35762179 |
51 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.35254985 |
52 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.35140752 |
53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.34388733 |
54 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.31667979 |
55 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.30784555 |
56 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.30363624 |
57 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.29678506 |
58 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.28712562 |
59 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.26817288 |
60 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26486325 |
61 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.25945501 |
62 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.25676234 |
63 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.25250708 |
64 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.25096287 |
65 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.22515773 |
66 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.22240231 |
67 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.21793580 |
68 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.21760915 |
69 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.19795646 |
70 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.17402671 |
71 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17247234 |
72 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.16737891 |
73 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.16630751 |
74 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.16447934 |
75 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.16399298 |
76 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.16329204 |
77 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.15931413 |
78 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.15151435 |
79 | * P68_20966046_ChIP-Seq_HELA_Human | 1.15073516 |
80 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 1.14442300 |
81 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.12695540 |
82 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 1.11558521 |
83 | SA1_27219007_Chip-Seq_Bcells_Human | 1.11491552 |
84 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.10616997 |
85 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.10545029 |
86 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09199547 |
87 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08941708 |
88 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.08532038 |
89 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.08476630 |
90 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.08028279 |
91 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.06461579 |
92 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.05243005 |
93 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04816138 |
94 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.04503845 |
95 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.03333950 |
96 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.02908393 |
97 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.02347641 |
98 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.02152738 |
99 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.01839084 |
100 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.01595581 |
101 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.01116596 |
102 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.00647328 |
103 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.00405394 |
104 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.99911398 |
105 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.99449499 |
106 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.99023448 |
107 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.98899449 |
108 | P300_27268052_Chip-Seq_Bcells_Human | 0.98846419 |
109 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.98311660 |
110 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.98292576 |
111 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.98219269 |
112 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.98088628 |
113 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.97850392 |
114 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.97302115 |
115 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.96146308 |
116 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.95061980 |
117 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.94976003 |
118 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94561209 |
119 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.93813496 |
120 | * E2F1_20622854_ChIP-Seq_HELA_Human | 0.93587622 |
121 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.93178086 |
122 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92848738 |
123 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.92693394 |
124 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.91967409 |
125 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.91663140 |
126 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.91306095 |
127 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89525356 |
128 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.89392948 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005410_abnormal_fertilization | 6.03079592 |
2 | MP0003806_abnormal_nucleotide_metabolis | 4.41880532 |
3 | MP0005670_abnormal_white_adipose | 3.87463172 |
4 | MP0003646_muscle_fatigue | 3.55905194 |
5 | MP0002837_dystrophic_cardiac_calcinosis | 3.38913184 |
6 | * MP0006036_abnormal_mitochondrial_physio | 2.85561323 |
7 | MP0004084_abnormal_cardiac_muscle | 2.68307654 |
8 | MP0005360_urolithiasis | 2.56680077 |
9 | * MP0003186_abnormal_redox_activity | 2.52061726 |
10 | MP0005464_abnormal_platelet_physiology | 2.34827191 |
11 | MP0000749_muscle_degeneration | 2.31743959 |
12 | MP0005332_abnormal_amino_acid | 2.27310994 |
13 | MP0005451_abnormal_body_composition | 2.23500144 |
14 | MP0002139_abnormal_hepatobiliary_system | 2.20762093 |
15 | MP0005666_abnormal_adipose_tissue | 2.18676049 |
16 | MP0000751_myopathy | 2.11978838 |
17 | MP0004036_abnormal_muscle_relaxation | 2.07738743 |
18 | MP0009840_abnormal_foam_cell | 1.97360457 |
19 | MP0004130_abnormal_muscle_cell | 1.97015829 |
20 | MP0004019_abnormal_vitamin_homeostasis | 1.95865867 |
21 | MP0000750_abnormal_muscle_regeneration | 1.91502775 |
22 | MP0003075_altered_response_to | 1.88076090 |
23 | MP0004043_abnormal_pH_regulation | 1.86281817 |
24 | MP0003698_abnormal_male_reproductive | 1.81087357 |
25 | MP0009643_abnormal_urine_homeostasis | 1.77993010 |
26 | MP0000003_abnormal_adipose_tissue | 1.74560591 |
27 | MP0005330_cardiomyopathy | 1.73385258 |
28 | MP0008875_abnormal_xenobiotic_pharmacok | 1.71747928 |
29 | MP0006035_abnormal_mitochondrial_morpho | 1.69987750 |
30 | MP0001929_abnormal_gametogenesis | 1.68675157 |
31 | MP0010030_abnormal_orbit_morphology | 1.68381156 |
32 | MP0003195_calcinosis | 1.66731571 |
33 | MP0002269_muscular_atrophy | 1.66690357 |
34 | MP0003172_abnormal_lysosome_physiology | 1.64761714 |
35 | MP0004215_abnormal_myocardial_fiber | 1.62407753 |
36 | MP0005319_abnormal_enzyme/_coenzyme | 1.58589387 |
37 | MP0008775_abnormal_heart_ventricle | 1.54958029 |
38 | MP0002132_abnormal_respiratory_system | 1.54883454 |
39 | MP0001756_abnormal_urination | 1.52370120 |
40 | MP0004233_abnormal_muscle_weight | 1.52087072 |
41 | MP0003329_amyloid_beta_deposits | 1.50582133 |
42 | MP0004272_abnormal_basement_membrane | 1.49913564 |
43 | MP0004510_myositis | 1.48847903 |
44 | MP0010329_abnormal_lipoprotein_level | 1.48636020 |
45 | MP0005165_increased_susceptibility_to | 1.47587326 |
46 | MP0003191_abnormal_cellular_cholesterol | 1.45919708 |
47 | MP0005636_abnormal_mineral_homeostasis | 1.45816076 |
48 | MP0005085_abnormal_gallbladder_physiolo | 1.45686910 |
49 | MP0000604_amyloidosis | 1.45597044 |
50 | MP0008438_abnormal_cutaneous_collagen | 1.44057806 |
51 | MP0004087_abnormal_muscle_fiber | 1.41213480 |
52 | MP0005365_abnormal_bile_salt | 1.40262597 |
53 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.39374748 |
54 | MP0002653_abnormal_ependyma_morphology | 1.38987721 |
55 | MP0003011_delayed_dark_adaptation | 1.38295423 |
56 | MP0005083_abnormal_biliary_tract | 1.37283097 |
57 | MP0005377_hearing/vestibular/ear_phenot | 1.36384329 |
58 | MP0003878_abnormal_ear_physiology | 1.36384329 |
59 | MP0001764_abnormal_homeostasis | 1.34407082 |
60 | MP0002160_abnormal_reproductive_system | 1.33604888 |
61 | MP0003705_abnormal_hypodermis_morpholog | 1.31713254 |
62 | MP0000858_altered_metastatic_potential | 1.31226177 |
63 | MP0005058_abnormal_lysosome_morphology | 1.30630225 |
64 | MP0005266_abnormal_metabolism | 1.29998878 |
65 | MP0009379_abnormal_foot_pigmentation | 1.29238351 |
66 | MP0005375_adipose_tissue_phenotype | 1.28825991 |
67 | MP0000358_abnormal_cell_content/ | 1.28343763 |
68 | MP0005385_cardiovascular_system_phenoty | 1.27254502 |
69 | MP0001544_abnormal_cardiovascular_syste | 1.27254502 |
70 | MP0003656_abnormal_erythrocyte_physiolo | 1.26969655 |
71 | MP0005257_abnormal_intraocular_pressure | 1.26745108 |
72 | MP0002118_abnormal_lipid_homeostasis | 1.26041461 |
73 | MP0004147_increased_porphyrin_level | 1.25602263 |
74 | MP0002332_abnormal_exercise_endurance | 1.23836290 |
75 | MP0002972_abnormal_cardiac_muscle | 1.22013920 |
76 | MP0000747_muscle_weakness | 1.20106752 |
77 | MP0000343_altered_response_to | 1.19485500 |
78 | MP0003221_abnormal_cardiomyocyte_apopto | 1.16759216 |
79 | MP0006138_congestive_heart_failure | 1.14627415 |
80 | MP0000681_abnormal_thyroid_gland | 1.14490240 |
81 | MP0005397_hematopoietic_system_phenotyp | 1.11354831 |
82 | MP0001545_abnormal_hematopoietic_system | 1.11354831 |
83 | MP0004185_abnormal_adipocyte_glucose | 1.11306056 |
84 | MP0003879_abnormal_hair_cell | 1.10214597 |
85 | MP0005620_abnormal_muscle_contractility | 1.10194183 |
86 | MP0001849_ear_inflammation | 1.09051083 |
87 | MP0005334_abnormal_fat_pad | 1.08025000 |
88 | MP0003303_peritoneal_inflammation | 1.06796455 |
89 | MP0002295_abnormal_pulmonary_circulatio | 1.05042112 |
90 | MP0002161_abnormal_fertility/fecundity | 1.01756770 |
91 | MP0002106_abnormal_muscle_physiology | 0.99879855 |
92 | MP0003123_paternal_imprinting | 0.99717986 |
93 | MP0001765_abnormal_ion_homeostasis | 0.99696973 |
94 | MP0003566_abnormal_cell_adhesion | 0.99421233 |
95 | MP0009333_abnormal_splenocyte_physiolog | 0.98935880 |
96 | MP0004858_abnormal_nervous_system | 0.98351262 |
97 | MP0000678_abnormal_parathyroid_gland | 0.97114589 |
98 | MP0010630_abnormal_cardiac_muscle | 0.96598570 |
99 | MP0003950_abnormal_plasma_membrane | 0.94619728 |
100 | MP0005275_abnormal_skin_tensile | 0.93777121 |
101 | MP0001881_abnormal_mammary_gland | 0.93249283 |
102 | MP0002210_abnormal_sex_determination | 0.92594622 |
103 | MP0005379_endocrine/exocrine_gland_phen | 0.92552303 |
104 | MP0000759_abnormal_skeletal_muscle | 0.92486080 |
105 | MP0002136_abnormal_kidney_physiology | 0.92475522 |
106 | MP0003959_abnormal_lean_body | 0.92272014 |
107 | MP0001145_abnormal_male_reproductive | 0.91806341 |
108 | MP0000609_abnormal_liver_physiology | 0.91297106 |
109 | MP0003693_abnormal_embryo_hatching | 0.90719304 |
110 | MP0005376_homeostasis/metabolism_phenot | 0.90671156 |
111 | MP0003453_abnormal_keratinocyte_physiol | 0.89900922 |
112 | MP0005501_abnormal_skin_physiology | 0.86276406 |
113 | MP0005535_abnormal_body_temperature | 0.85960446 |
114 | MP0001958_emphysema | 0.85403879 |
115 | MP0002971_abnormal_brown_adipose | 0.85012573 |
116 | MP0009115_abnormal_fat_cell | 0.84502013 |
117 | MP0002877_abnormal_melanocyte_morpholog | 0.82152315 |
118 | MP0001661_extended_life_span | 0.82085274 |
119 | MP0009780_abnormal_chondrocyte_physiolo | 0.79557709 |
120 | MP0003638_abnormal_response/metabolism_ | 0.78136062 |
121 | MP0002078_abnormal_glucose_homeostasis | 0.77893609 |
122 | MP0004957_abnormal_blastocyst_morpholog | 0.77009373 |
123 | MP0000013_abnormal_adipose_tissue | 0.76890541 |
124 | MP0005167_abnormal_blood-brain_barrier | 0.76826690 |
125 | MP0001727_abnormal_embryo_implantation | 0.75782881 |
126 | MP0008874_decreased_physiological_sensi | 0.75718517 |
127 | MP0002148_abnormal_hypersensitivity_rea | 0.75400139 |
128 | MP0005369_muscle_phenotype | 0.74800386 |
129 | MP0004133_heterotaxia | 0.73860406 |
130 | MP0005166_decreased_susceptibility_to | 0.73529425 |
131 | MP0001853_heart_inflammation | 0.73179607 |
132 | MP0009278_abnormal_bone_marrow | 0.73031270 |
133 | MP0005448_abnormal_energy_balance | 0.72040150 |
134 | MP0009642_abnormal_blood_homeostasis | 0.71342470 |
135 | MP0008469_abnormal_protein_level | 0.70476320 |
136 | MP0002970_abnormal_white_adipose | 0.70233015 |
137 | MP0005623_abnormal_meninges_morphology | 0.68671061 |
138 | MP0005452_abnormal_adipose_tissue | 0.68328823 |
139 | MP0002254_reproductive_system_inflammat | 0.67457660 |
140 | MP0003718_maternal_effect | 0.66994505 |
141 | MP0002876_abnormal_thyroid_physiology | 0.66801443 |
142 | MP0000598_abnormal_liver_morphology | 0.66556645 |
143 | MP0000249_abnormal_blood_vessel | 0.66232929 |
144 | MP0008260_abnormal_autophagy | 0.65966131 |
145 | MP0000653_abnormal_sex_gland | 0.65519564 |
146 | MP0001542_abnormal_bone_strength | 0.64421817 |
147 | MP0001730_embryonic_growth_arrest | 0.63712767 |
148 | MP0003279_aneurysm | 0.63498740 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 4.05284793 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.02051816 |
3 | Acute encephalopathy (HP:0006846) | 3.93202092 |
4 | Myoglobinuria (HP:0002913) | 3.83196214 |
5 | Hepatic necrosis (HP:0002605) | 3.75065233 |
6 | Hyperglycinuria (HP:0003108) | 3.68539062 |
7 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.66266894 |
8 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.66266894 |
9 | Cerebral edema (HP:0002181) | 3.55629574 |
10 | Vertebral compression fractures (HP:0002953) | 3.55575021 |
11 | Rhabdomyolysis (HP:0003201) | 3.54614511 |
12 | Purpura (HP:0000979) | 3.54069279 |
13 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.51240721 |
14 | Hepatocellular necrosis (HP:0001404) | 3.48058755 |
15 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.41757291 |
16 | Mitochondrial inheritance (HP:0001427) | 3.32648373 |
17 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.31981395 |
18 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.31981395 |
19 | Abnormality of glycolipid metabolism (HP:0010969) | 3.31981395 |
20 | Systemic lupus erythematosus (HP:0002725) | 3.31350266 |
21 | Absent/shortened dynein arms (HP:0200106) | 3.28889767 |
22 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.28889767 |
23 | Muscle fiber splitting (HP:0003555) | 3.25516507 |
24 | Renal Fanconi syndrome (HP:0001994) | 3.18041470 |
25 | Progressive macrocephaly (HP:0004481) | 3.15595734 |
26 | Gout (HP:0001997) | 3.15294527 |
27 | Dicarboxylic aciduria (HP:0003215) | 3.13755246 |
28 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.13755246 |
29 | Increased CSF lactate (HP:0002490) | 3.12089338 |
30 | Increased muscle lipid content (HP:0009058) | 3.10265942 |
31 | Xanthomatosis (HP:0000991) | 3.09309357 |
32 | Petechiae (HP:0000967) | 3.08043343 |
33 | Abnormality of glycine metabolism (HP:0010895) | 3.05462516 |
34 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.05462516 |
35 | Palpitations (HP:0001962) | 2.99046606 |
36 | Dysostosis multiplex (HP:0000943) | 2.96597605 |
37 | Exercise-induced muscle cramps (HP:0003710) | 2.93511320 |
38 | Lactic acidosis (HP:0003128) | 2.93481534 |
39 | Lethargy (HP:0001254) | 2.93427460 |
40 | Chronic bronchitis (HP:0004469) | 2.91200874 |
41 | Vacuolated lymphocytes (HP:0001922) | 2.84952502 |
42 | Hyperammonemia (HP:0001987) | 2.80143348 |
43 | Respiratory failure (HP:0002878) | 2.79235859 |
44 | Nuclear cataract (HP:0100018) | 2.78053604 |
45 | Hyporeflexia of lower limbs (HP:0002600) | 2.69594867 |
46 | Proximal tubulopathy (HP:0000114) | 2.68853830 |
47 | Generalized aminoaciduria (HP:0002909) | 2.68013008 |
48 | Nausea (HP:0002018) | 2.64773002 |
49 | Abnormality of the Achilles tendon (HP:0005109) | 2.64423572 |
50 | Multiple enchondromatosis (HP:0005701) | 2.62910285 |
51 | Acanthosis nigricans (HP:0000956) | 2.60700316 |
52 | Cholecystitis (HP:0001082) | 2.59632863 |
53 | Abnormal gallbladder physiology (HP:0012438) | 2.59632863 |
54 | Hepatosplenomegaly (HP:0001433) | 2.57192503 |
55 | Exercise intolerance (HP:0003546) | 2.56904703 |
56 | Abnormality of glycolysis (HP:0004366) | 2.56815266 |
57 | Increased serum pyruvate (HP:0003542) | 2.56815266 |
58 | Prolonged neonatal jaundice (HP:0006579) | 2.56806599 |
59 | Increased intramyocellular lipid droplets (HP:0012240) | 2.50342199 |
60 | Nasal polyposis (HP:0100582) | 2.49998093 |
61 | Sudden death (HP:0001699) | 2.49549997 |
62 | Ketosis (HP:0001946) | 2.47790373 |
63 | Hyperuricemia (HP:0002149) | 2.46578969 |
64 | Increased purine levels (HP:0004368) | 2.46578969 |
65 | Abnormality of the nasal mucosa (HP:0000433) | 2.45041534 |
66 | Distal lower limb muscle weakness (HP:0009053) | 2.43357585 |
67 | Achilles tendon contracture (HP:0001771) | 2.42287485 |
68 | Hyperlipoproteinemia (HP:0010980) | 2.39344878 |
69 | Vomiting (HP:0002013) | 2.39075212 |
70 | Leukodystrophy (HP:0002415) | 2.35972187 |
71 | Hyperglycinemia (HP:0002154) | 2.35954336 |
72 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.35651010 |
73 | Abnormality of renal excretion (HP:0011036) | 2.33381570 |
74 | Ketoacidosis (HP:0001993) | 2.32288389 |
75 | Exercise-induced myalgia (HP:0003738) | 2.31686178 |
76 | Renal salt wasting (HP:0000127) | 2.31451296 |
77 | Complement deficiency (HP:0004431) | 2.31041973 |
78 | Abnormality of complement system (HP:0005339) | 2.29625945 |
79 | Myotonia (HP:0002486) | 2.28438923 |
80 | Increased serum lactate (HP:0002151) | 2.28135770 |
81 | Growth hormone excess (HP:0000845) | 2.27445503 |
82 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.27369215 |
83 | Difficulty climbing stairs (HP:0003551) | 2.26385050 |
84 | Infertility (HP:0000789) | 2.24742123 |
85 | CNS demyelination (HP:0007305) | 2.24503395 |
86 | Progressive neurologic deterioration (HP:0002344) | 2.24488185 |
87 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.23624351 |
88 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.23624351 |
89 | Hyperthyroidism (HP:0000836) | 2.23240125 |
90 | Ventricular tachycardia (HP:0004756) | 2.23221859 |
91 | Increased serum ferritin (HP:0003281) | 2.23133994 |
92 | Pheochromocytoma (HP:0002666) | 2.22800114 |
93 | Asymmetric septal hypertrophy (HP:0001670) | 2.21528408 |
94 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.20498688 |
95 | Abnormal urine output (HP:0012590) | 2.20337740 |
96 | Testicular atrophy (HP:0000029) | 2.20003114 |
97 | Loss of speech (HP:0002371) | 2.19654038 |
98 | Lipoatrophy (HP:0100578) | 2.19109721 |
99 | Neuroendocrine neoplasm (HP:0100634) | 2.18846941 |
100 | Hypoglycemic coma (HP:0001325) | 2.18410624 |
101 | Protrusio acetabuli (HP:0003179) | 2.18218846 |
102 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.17611251 |
103 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.16872437 |
104 | Muscle stiffness (HP:0003552) | 2.16464012 |
105 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.15687354 |
106 | Neoplasm of head and neck (HP:0012288) | 2.15439866 |
107 | Esophageal neoplasm (HP:0100751) | 2.15439866 |
108 | Polyuria (HP:0000103) | 2.15278919 |
109 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.15211152 |
110 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.15211152 |
111 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.15211152 |
112 | Myocardial infarction (HP:0001658) | 2.14642101 |
113 | Amyloidosis (HP:0011034) | 2.13592918 |
114 | Stridor (HP:0010307) | 2.13254992 |
115 | Insulin resistance (HP:0000855) | 2.12418175 |
116 | Abnormality of purine metabolism (HP:0004352) | 2.09142879 |
117 | Glycosuria (HP:0003076) | 2.08940476 |
118 | Abnormality of urine glucose concentration (HP:0011016) | 2.08940476 |
119 | Oligomenorrhea (HP:0000876) | 2.06976659 |
120 | Hypokalemic alkalosis (HP:0001949) | 2.06749104 |
121 | Generalized muscle weakness (HP:0003324) | 2.06360182 |
122 | Conjunctival hamartoma (HP:0100780) | 2.06286642 |
123 | Lipid accumulation in hepatocytes (HP:0006561) | 2.06181729 |
124 | Rhinitis (HP:0012384) | 2.05385290 |
125 | Menorrhagia (HP:0000132) | 2.05147708 |
126 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.04483771 |
127 | Increased connective tissue (HP:0009025) | 2.03119768 |
128 | Methylmalonic aciduria (HP:0012120) | 2.01588995 |
129 | Increased hepatocellular lipid droplets (HP:0006565) | 1.99746483 |
130 | Mucopolysacchariduria (HP:0008155) | 1.99515810 |
131 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.99515810 |
132 | Progressive muscle weakness (HP:0003323) | 1.98891636 |
133 | Opisthotonus (HP:0002179) | 1.98490808 |
134 | Right ventricular cardiomyopathy (HP:0011663) | 1.98323515 |
135 | Rough bone trabeculation (HP:0100670) | 1.97141755 |
136 | Ragged-red muscle fibers (HP:0003200) | 1.96334810 |
137 | Metabolic acidosis (HP:0001942) | 1.95515274 |
138 | Deep venous thrombosis (HP:0002625) | 1.94757986 |
139 | Optic disc pallor (HP:0000543) | 1.92867502 |
140 | Emotional lability (HP:0000712) | 1.91889567 |
141 | Exertional dyspnea (HP:0002875) | 1.90620931 |
142 | Hypoalphalipoproteinemia (HP:0003233) | 1.89965267 |
143 | Hypertensive crisis (HP:0100735) | 1.89522681 |
144 | Atelectasis (HP:0100750) | 1.89429565 |
145 | Axonal loss (HP:0003447) | 1.88407592 |
146 | Hypertriglyceridemia (HP:0002155) | 1.88001887 |
147 | Fasciculations (HP:0002380) | 1.86816989 |
148 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.85729173 |
149 | Cholelithiasis (HP:0001081) | 1.84376632 |
150 | Upper limb amyotrophy (HP:0009129) | 1.83559605 |
151 | Distal upper limb amyotrophy (HP:0007149) | 1.83559605 |
152 | Abnormality of serum amino acid levels (HP:0003112) | 1.83096564 |
153 | Hypercholesterolemia (HP:0003124) | 1.81629270 |
154 | Hemorrhage of the eye (HP:0011885) | 1.81309493 |
155 | Glomerulonephritis (HP:0000099) | 1.80485902 |
156 | Cervical subluxation (HP:0003308) | 1.79999377 |
157 | Retinal atrophy (HP:0001105) | 1.79317759 |
158 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.79263050 |
159 | Cerebral palsy (HP:0100021) | 1.77914136 |
160 | Polygenic inheritance (HP:0010982) | 1.74711869 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PDK4 | 5.77447919 |
2 | PDK3 | 5.77447919 |
3 | TESK1 | 5.09301210 |
4 | PDK2 | 4.10644672 |
5 | BCKDK | 3.57342823 |
6 | VRK2 | 3.40971605 |
7 | NME2 | 3.16640185 |
8 | IRAK3 | 2.79433809 |
9 | NEK1 | 2.76318550 |
10 | WNK4 | 2.18513009 |
11 | ARAF | 2.02079409 |
12 | TESK2 | 2.01776133 |
13 | TRIB3 | 1.97016828 |
14 | SMG1 | 1.86214803 |
15 | TAOK2 | 1.84594849 |
16 | LMTK2 | 1.77412946 |
17 | PRKD3 | 1.76603307 |
18 | EPHA2 | 1.73193222 |
19 | MYLK | 1.70918665 |
20 | BUB1 | 1.67730276 |
21 | MAPKAPK3 | 1.65143106 |
22 | PINK1 | 1.54859441 |
23 | TTN | 1.53567587 |
24 | PIM2 | 1.50334865 |
25 | LIMK1 | 1.48329986 |
26 | ICK | 1.38785629 |
27 | EPHB2 | 1.38705188 |
28 | WEE1 | 1.36763368 |
29 | PKN2 | 1.28428717 |
30 | MAP3K11 | 1.19829549 |
31 | DAPK1 | 1.19417349 |
32 | DDR2 | 1.19074004 |
33 | PTK2B | 1.17165097 |
34 | PAK4 | 1.14824760 |
35 | BMX | 1.14350912 |
36 | LRRK2 | 1.11143588 |
37 | BRAF | 1.09790558 |
38 | EIF2AK1 | 1.09257496 |
39 | OBSCN | 1.07490790 |
40 | STK39 | 1.02611532 |
41 | STK38 | 1.01758402 |
42 | DAPK3 | 1.01220471 |
43 | ILK | 0.97466358 |
44 | PRPF4B | 0.96873620 |
45 | NEK2 | 0.95577177 |
46 | STK38L | 0.94078406 |
47 | RPS6KB2 | 0.92565794 |
48 | ERN1 | 0.87299491 |
49 | GRK5 | 0.86177651 |
50 | WNK3 | 0.84378672 |
51 | MAP3K12 | 0.83165462 |
52 | KDR | 0.81388030 |
53 | TIE1 | 0.81154779 |
54 | MAP2K3 | 0.80677072 |
55 | MAP3K3 | 0.80390293 |
56 | ABL2 | 0.78188527 |
57 | SCYL2 | 0.77063775 |
58 | NME1 | 0.76801355 |
59 | MST1R | 0.76793588 |
60 | PAK1 | 0.73693124 |
61 | PHKG2 | 0.69933170 |
62 | PHKG1 | 0.69933170 |
63 | PDPK1 | 0.67378147 |
64 | MET | 0.67238576 |
65 | MAP3K1 | 0.66900103 |
66 | MAP2K2 | 0.64700006 |
67 | PTK2 | 0.62417871 |
68 | PDK1 | 0.61460420 |
69 | OXSR1 | 0.61234367 |
70 | CSNK1G3 | 0.61010702 |
71 | FLT3 | 0.60084559 |
72 | TTK | 0.59507684 |
73 | MOS | 0.57764007 |
74 | AURKA | 0.55655719 |
75 | PRKG2 | 0.55354409 |
76 | AKT2 | 0.54497900 |
77 | MAP3K8 | 0.54096690 |
78 | TAOK1 | 0.48913197 |
79 | CAMK1D | 0.48205506 |
80 | KSR2 | 0.47703345 |
81 | MAP2K1 | 0.47332951 |
82 | MUSK | 0.47264876 |
83 | CDK8 | 0.46347682 |
84 | DYRK3 | 0.45134416 |
85 | CDK11A | 0.43870521 |
86 | STK16 | 0.42836759 |
87 | CDK14 | 0.41561867 |
88 | NEK9 | 0.41349829 |
89 | DYRK1B | 0.41193435 |
90 | MST4 | 0.39018277 |
91 | MAPK11 | 0.38833783 |
92 | IKBKB | 0.38427138 |
93 | VRK1 | 0.37283899 |
94 | CDK15 | 0.36208201 |
95 | PLK4 | 0.36170703 |
96 | PKN1 | 0.35770065 |
97 | PRKCI | 0.35700274 |
98 | RIPK4 | 0.34910103 |
99 | TGFBR2 | 0.34843423 |
100 | CDC42BPA | 0.34579404 |
101 | CAMK2G | 0.34166300 |
102 | MAPK4 | 0.33694353 |
103 | CAMKK2 | 0.32682040 |
104 | CDK18 | 0.30883150 |
105 | ZAK | 0.30380877 |
106 | EIF2AK3 | 0.30341142 |
107 | PRKD2 | 0.29987979 |
108 | TYK2 | 0.29646408 |
109 | PBK | 0.29169948 |
110 | HIPK2 | 0.28886039 |
111 | MAPKAPK5 | 0.28669710 |
112 | CDK9 | 0.28571548 |
113 | SIK1 | 0.28550675 |
114 | PRKAA2 | 0.27931706 |
115 | GSK3A | 0.27386757 |
116 | RAF1 | 0.26027621 |
117 | EEF2K | 0.25848381 |
118 | PAK2 | 0.25781074 |
119 | IRAK2 | 0.25200095 |
120 | TLK1 | 0.24803453 |
121 | PAK6 | 0.24603938 |
122 | MAP2K6 | 0.24568186 |
123 | CSNK1A1L | 0.24038132 |
124 | PLK1 | 0.23817162 |
125 | FER | 0.23020297 |
126 | RPS6KA5 | 0.22587843 |
127 | CSNK2A1 | 0.21715563 |
128 | BRSK2 | 0.21494631 |
129 | STK4 | 0.21437254 |
130 | PIM1 | 0.19468698 |
131 | LATS2 | 0.19160606 |
132 | RIPK1 | 0.18461717 |
133 | PRKACG | 0.18400453 |
134 | RPS6KC1 | 0.18288932 |
135 | RPS6KL1 | 0.18288932 |
136 | CAMK2D | 0.16612435 |
137 | RPS6KA6 | 0.15915959 |
138 | CCNB1 | 0.15519172 |
139 | CSNK2A2 | 0.15467490 |
140 | TBK1 | 0.15185050 |
141 | PRKCD | 0.14997341 |
142 | BRSK1 | 0.14672630 |
143 | PRKD1 | 0.14627257 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.12318362 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.34584111 |
3 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.25201180 |
4 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.18381859 |
5 | Pyruvate metabolism_Homo sapiens_hsa00620 | 3.07512847 |
6 | Parkinsons disease_Homo sapiens_hsa05012 | 3.03868049 |
7 | Carbon metabolism_Homo sapiens_hsa01200 | 2.64408291 |
8 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.56711770 |
9 | Proteasome_Homo sapiens_hsa03050 | 2.42295874 |
10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.32704068 |
11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.29788303 |
12 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 2.29727203 |
13 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.16562633 |
14 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.10799683 |
15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.98862917 |
16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.93719164 |
17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.92991597 |
18 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.90582389 |
19 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.82548698 |
20 | Ribosome_Homo sapiens_hsa03010 | 1.81704925 |
21 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.68508339 |
22 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.62187906 |
23 | Sulfur relay system_Homo sapiens_hsa04122 | 1.53665916 |
24 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.52671106 |
25 | Peroxisome_Homo sapiens_hsa04146 | 1.47532045 |
26 | * Glutathione metabolism_Homo sapiens_hsa00480 | 1.45155416 |
27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.40122312 |
28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.37623214 |
29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.35675704 |
30 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.30220579 |
31 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.28073450 |
32 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.26463182 |
33 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.26348014 |
34 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.24425401 |
35 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.17838797 |
36 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.16535830 |
37 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.15731602 |
38 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.15599519 |
39 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.13026826 |
40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.11019911 |
41 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.10030116 |
42 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.09108777 |
43 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.06907191 |
44 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.03365262 |
45 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.02960709 |
46 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.00084049 |
47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.99133513 |
48 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.94915992 |
49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.94224157 |
50 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.93681932 |
51 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.93232157 |
52 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.93160078 |
53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.92421105 |
54 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.90311977 |
55 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.90114601 |
56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.89653465 |
57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.88743442 |
58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88333649 |
59 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.87523058 |
60 | Base excision repair_Homo sapiens_hsa03410 | 0.86104634 |
61 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.83842282 |
62 | DNA replication_Homo sapiens_hsa03030 | 0.82486190 |
63 | RNA polymerase_Homo sapiens_hsa03020 | 0.77175093 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.75799150 |
65 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.75703978 |
66 | Galactose metabolism_Homo sapiens_hsa00052 | 0.74681808 |
67 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.70608265 |
68 | Prion diseases_Homo sapiens_hsa05020 | 0.70563686 |
69 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.70320031 |
70 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.68362199 |
71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.68138075 |
72 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.67928517 |
73 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.67212837 |
74 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.65021152 |
75 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62787959 |
76 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.62019780 |
77 | Purine metabolism_Homo sapiens_hsa00230 | 0.58870114 |
78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56712810 |
79 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.55803188 |
80 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.55235469 |
81 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.54714220 |
82 | Histidine metabolism_Homo sapiens_hsa00340 | 0.51399763 |
83 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.50103380 |
84 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.47168723 |
85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.45371599 |
86 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.44539584 |
87 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.44137161 |
88 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.43819188 |
89 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43415575 |
90 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.42512273 |
91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.41106718 |
92 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.40733173 |
93 | Mismatch repair_Homo sapiens_hsa03430 | 0.40452958 |
94 | Bile secretion_Homo sapiens_hsa04976 | 0.40425505 |
95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.38437001 |
96 | RNA transport_Homo sapiens_hsa03013 | 0.38162708 |
97 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36374561 |
98 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.33940396 |
99 | Mineral absorption_Homo sapiens_hsa04978 | 0.33222221 |
100 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.33086714 |
101 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.31738755 |
102 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.31625681 |
103 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.30451178 |
104 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.29813894 |
105 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.28258817 |
106 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.28124987 |
107 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.27395576 |
108 | Lysosome_Homo sapiens_hsa04142 | 0.27026891 |
109 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.26410618 |
110 | Other glycan degradation_Homo sapiens_hsa00511 | 0.25922338 |
111 | Shigellosis_Homo sapiens_hsa05131 | 0.25881128 |
112 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25367635 |
113 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.25314381 |
114 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.25025629 |
115 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.23677527 |
116 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.23395152 |
117 | Salmonella infection_Homo sapiens_hsa05132 | 0.22372609 |
118 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.22229292 |
119 | Endocytosis_Homo sapiens_hsa04144 | 0.22121678 |