GPX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)6.60326143
2cell wall macromolecule catabolic process (GO:0016998)6.60326143
3fusion of sperm to egg plasma membrane (GO:0007342)5.53051778
4sequestering of actin monomers (GO:0042989)5.47865263
5tricarboxylic acid cycle (GO:0006099)5.26642039
6protein maturation by protein folding (GO:0022417)5.05506937
7sperm-egg recognition (GO:0035036)5.04376669
8binding of sperm to zona pellucida (GO:0007339)4.79786760
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74915498
10sperm motility (GO:0030317)4.69796256
11organic cation transport (GO:0015695)4.69646823
12acrosome reaction (GO:0007340)4.60680869
13oxidative phosphorylation (GO:0006119)4.46698452
14cell-cell recognition (GO:0009988)4.41874788
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40122146
16ATP synthesis coupled proton transport (GO:0015986)4.40122146
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.33846325
18NADH metabolic process (GO:0006734)4.24369763
19plasma membrane fusion (GO:0045026)4.17031448
20L-phenylalanine catabolic process (GO:0006559)4.16863196
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16863196
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.16708886
23respiratory electron transport chain (GO:0022904)4.11669905
24electron transport chain (GO:0022900)4.06814741
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06419315
26amino-acid betaine transport (GO:0015838)4.05954258
27carnitine transport (GO:0015879)4.05954258
28acrosome assembly (GO:0001675)3.98379058
29regulation of cholesterol esterification (GO:0010872)3.89009833
30lysine catabolic process (GO:0006554)3.82136663
31lysine metabolic process (GO:0006553)3.82136663
32carnitine transmembrane transport (GO:1902603)3.73819888
33multicellular organism reproduction (GO:0032504)3.72203580
34aspartate family amino acid catabolic process (GO:0009068)3.70244617
35spermatid development (GO:0007286)3.67203666
36triglyceride catabolic process (GO:0019433)3.66270901
37ATP biosynthetic process (GO:0006754)3.62400541
38quaternary ammonium group transport (GO:0015697)3.59122012
39acylglycerol catabolic process (GO:0046464)3.57585594
40neutral lipid catabolic process (GO:0046461)3.57585594
41fatty acid beta-oxidation (GO:0006635)3.53175364
42positive regulation of triglyceride lipase activity (GO:0061365)3.52697661
43positive regulation of lipoprotein lipase activity (GO:0051006)3.52697661
44motile cilium assembly (GO:0044458)3.47997016
45proline biosynthetic process (GO:0006561)3.43106690
46reproduction (GO:0000003)3.42130485
47response to mercury ion (GO:0046689)3.39862063
48plasma lipoprotein particle clearance (GO:0034381)3.37709334
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36861739
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31617723
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30175078
52chaperone-mediated protein complex assembly (GO:0051131)3.29910807
53GDP-mannose metabolic process (GO:0019673)3.29899788
54oxaloacetate metabolic process (GO:0006107)3.26933049
55low-density lipoprotein particle clearance (GO:0034383)3.26848888
56branched-chain amino acid catabolic process (GO:0009083)3.26686829
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23155736
58hydrogen ion transmembrane transport (GO:1902600)3.22363449
59ADP metabolic process (GO:0046031)3.20818034
60alditol metabolic process (GO:0019400)3.20814007
61glucose catabolic process (GO:0006007)3.18609692
62COPI coating of Golgi vesicle (GO:0048205)3.18265766
63Golgi transport vesicle coating (GO:0048200)3.18265766
64tricarboxylic acid metabolic process (GO:0072350)3.17327230
65sperm capacitation (GO:0048240)3.16343680
66valine metabolic process (GO:0006573)3.15951956
67carnitine shuttle (GO:0006853)3.11639010
68acetyl-CoA metabolic process (GO:0006084)3.11145729
69fatty acid catabolic process (GO:0009062)3.09810869
70ribonucleoside triphosphate biosynthetic process (GO:0009201)3.09006034
712-oxoglutarate metabolic process (GO:0006103)3.08913601
72protein retention in ER lumen (GO:0006621)3.08383428
73branched-chain amino acid metabolic process (GO:0009081)3.08137621
74peptidyl-glutamic acid carboxylation (GO:0017187)3.06287750
75protein carboxylation (GO:0018214)3.06287750
76carnitine metabolic process (GO:0009437)3.02220795
77fatty acid oxidation (GO:0019395)3.01475536
78fatty acid transmembrane transport (GO:1902001)3.01349257
79barbed-end actin filament capping (GO:0051016)3.00997022
80pentose metabolic process (GO:0019321)2.99936858
81succinate metabolic process (GO:0006105)2.99055218
82lipid particle organization (GO:0034389)2.99037107
83DNA deamination (GO:0045006)2.98580055
84synaptonemal complex organization (GO:0070193)2.97484275
85ribosomal small subunit biogenesis (GO:0042274)2.97374306
86synaptonemal complex assembly (GO:0007130)2.96955429
87NADPH regeneration (GO:0006740)2.96770166
88negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.96443235
89chaperone-mediated protein transport (GO:0072321)2.95943707
90lipid oxidation (GO:0034440)2.95794071
91axonemal dynein complex assembly (GO:0070286)2.94698357
92nucleoside triphosphate biosynthetic process (GO:0009142)2.94256750
93regulation of cilium movement (GO:0003352)2.87670278
94purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.87283540
95purine nucleoside monophosphate biosynthetic process (GO:0009127)2.87283540
96regulation of mitochondrial translation (GO:0070129)2.86972174
97epithelial cilium movement (GO:0003351)2.84838566
98extracellular fibril organization (GO:0043206)2.82960926
99aldehyde catabolic process (GO:0046185)2.82202045
100regulation of sequestering of triglyceride (GO:0010889)2.82057139
101fructose metabolic process (GO:0006000)2.81083311
102establishment of protein localization to mitochondrial membrane (GO:0090151)2.80802404
103polyketide metabolic process (GO:0030638)2.79322701
104doxorubicin metabolic process (GO:0044598)2.79322701
105daunorubicin metabolic process (GO:0044597)2.79322701
106glycerolipid catabolic process (GO:0046503)2.78581593
107regulation of cholesterol storage (GO:0010885)2.78193980
108monosaccharide biosynthetic process (GO:0046364)2.77986801
109regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77792961
110alpha-linolenic acid metabolic process (GO:0036109)2.76648507
111nucleobase-containing small molecule interconversion (GO:0015949)2.76007955
112hexose biosynthetic process (GO:0019319)2.75857510
113proline metabolic process (GO:0006560)2.75605831
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75254943
115UV protection (GO:0009650)2.73946087
116regulation of cellular amino acid metabolic process (GO:0006521)2.73114683
117fatty acid homeostasis (GO:0055089)2.71852207
118glycerol metabolic process (GO:0006071)2.71804365
119biotin metabolic process (GO:0006768)2.70908307
120glycolytic process (GO:0006096)2.69553699
121cysteine metabolic process (GO:0006534)2.69446496
122L-ascorbic acid metabolic process (GO:0019852)2.68570576
123proton transport (GO:0015992)2.67955453
124amino-acid betaine metabolic process (GO:0006577)2.67230651
125gluconeogenesis (GO:0006094)2.67161847
126guanosine-containing compound biosynthetic process (GO:1901070)2.66976330
127ATP hydrolysis coupled proton transport (GO:0015991)2.66858516
128energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.66858516
129ribonucleoside monophosphate biosynthetic process (GO:0009156)2.66595585
130hydrogen transport (GO:0006818)2.66309808
131ethanol oxidation (GO:0006069)2.64856516
132heme biosynthetic process (GO:0006783)2.64653635
133pentose-phosphate shunt (GO:0006098)2.64428527
134negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.63840138
135mitochondrial fusion (GO:0008053)2.62992823
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62913253
137L-phenylalanine metabolic process (GO:0006558)2.62913253
138positive regulation of cellular amine metabolic process (GO:0033240)2.62761407
139regulation of oxidative phosphorylation (GO:0002082)2.61957816
140glyoxylate metabolic process (GO:0046487)2.61354386
141nitrogen cycle metabolic process (GO:0071941)2.60059242
142single fertilization (GO:0007338)2.59597321
143monocarboxylic acid catabolic process (GO:0072329)2.59588886
144mitochondrial transport (GO:0006839)2.59134089
145protein targeting to mitochondrion (GO:0006626)2.58420198
146CDP-diacylglycerol metabolic process (GO:0046341)2.57380753
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57296781
148urea cycle (GO:0000050)2.57277036
149NADP metabolic process (GO:0006739)2.57262473
1502-deoxyribonucleotide biosynthetic process (GO:0009265)2.54996744
151deoxyribose phosphate biosynthetic process (GO:0046385)2.54996744
152nucleoside diphosphate biosynthetic process (GO:0009133)2.53685256
153GTP biosynthetic process (GO:0006183)2.50191025
154regulation of cholesterol transport (GO:0032374)2.46083175
155regulation of sterol transport (GO:0032371)2.46083175
156heme metabolic process (GO:0042168)2.45544952
157endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.45209780
158urea metabolic process (GO:0019627)2.44527231
159viral transcription (GO:0019083)2.43714027
160* hydrogen peroxide catabolic process (GO:0042744)2.42895563
161primary alcohol catabolic process (GO:0034310)2.42684812
162positive regulation of fatty acid biosynthetic process (GO:0045723)2.41889916
163blood coagulation, intrinsic pathway (GO:0007597)2.40597723
164aminoglycoside antibiotic metabolic process (GO:0030647)2.40090789
165mitotic nuclear envelope reassembly (GO:0007084)2.39314251
166nuclear envelope reassembly (GO:0031468)2.39314251
167pinocytosis (GO:0006907)2.38374134
168fibril organization (GO:0097435)2.37828811
169retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37750578
170establishment of protein localization to mitochondrion (GO:0072655)2.36472713
171protein complex biogenesis (GO:0070271)2.35684668
172cyclooxygenase pathway (GO:0019371)2.35382544
173UTP biosynthetic process (GO:0006228)2.33085624
174regulation of mitochondrial membrane potential (GO:0051881)2.32850712
175glutathione biosynthetic process (GO:0006750)2.31761392
176diacylglycerol metabolic process (GO:0046339)2.31433995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.20546318
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.20857635
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44713805
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.01274376
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.88586513
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84383871
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54755542
8ZNF263_19887448_ChIP-Seq_K562_Human2.45401369
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.39931339
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.38696218
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37515757
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.37394265
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18445176
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14441601
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14428581
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13031574
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08015098
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.04898912
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00315009
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93000440
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.91863827
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.87830388
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.86080996
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84670923
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82091881
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.77351604
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.75727926
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69685347
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.67753764
30* VDR_21846776_ChIP-Seq_THP-1_Human1.67220826
31* RACK7_27058665_Chip-Seq_MCF-7_Human1.65905323
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62574997
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62570833
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62275012
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62165447
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56097461
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55363852
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54953143
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54756676
40* SRF_21415370_ChIP-Seq_HL-1_Mouse1.52559293
41* TET1_21451524_ChIP-Seq_MESCs_Mouse1.52558952
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.52490407
43* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52125242
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51541684
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45911835
46XRN2_22483619_ChIP-Seq_HELA_Human1.45108033
47* SA1_27219007_Chip-Seq_ERYTHROID_Human1.41018480
48BCOR_27268052_Chip-Seq_Bcells_Human1.36823803
49DCP1A_22483619_ChIP-Seq_HELA_Human1.35822401
50SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35762179
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35254985
52BCL6_27268052_Chip-Seq_Bcells_Human1.35140752
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34388733
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31667979
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30784555
56* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30363624
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29678506
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.28712562
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26817288
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26486325
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.25945501
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25676234
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25250708
64* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25096287
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22515773
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22240231
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21793580
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21760915
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19795646
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17402671
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17247234
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16737891
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16630751
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16447934
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16399298
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16329204
77SMC4_20622854_ChIP-Seq_HELA_Human1.15931413
78GABP_19822575_ChIP-Seq_HepG2_Human1.15151435
79* P68_20966046_ChIP-Seq_HELA_Human1.15073516
80NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14442300
81* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12695540
82RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11558521
83SA1_27219007_Chip-Seq_Bcells_Human1.11491552
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.10616997
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10545029
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09199547
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08941708
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08532038
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08476630
90* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08028279
91CTCF_27219007_Chip-Seq_Bcells_Human1.06461579
92PHF8_20622854_ChIP-Seq_HELA_Human1.05243005
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04816138
94* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04503845
95CTCF_21964334_Chip-Seq_Bcells_Human1.03333950
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02908393
97* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02347641
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.02152738
99SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01839084
100CTCF_20526341_ChIP-Seq_ESCs_Human1.01595581
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01116596
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00647328
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00405394
104ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99911398
105GATA3_21867929_ChIP-Seq_CD8_Mouse0.99449499
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99023448
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98899449
108P300_27268052_Chip-Seq_Bcells_Human0.98846419
109* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98311660
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98292576
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98219269
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98088628
113RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97850392
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97302115
115RARA_24833708_ChIP-Seq_LIVER_Mouse0.96146308
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95061980
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94976003
118* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94561209
119VDR_23849224_ChIP-Seq_CD4+_Human0.93813496
120* E2F1_20622854_ChIP-Seq_HELA_Human0.93587622
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93178086
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92848738
123SPI1_20517297_ChIP-Seq_HL60_Human0.92693394
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91967409
125* LXR_22292898_ChIP-Seq_THP-1_Human0.91663140
126* ATF3_27146783_Chip-Seq_COLON_Human0.91306095
127* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89525356
128CLOCK_20551151_ChIP-Seq_293T_Human0.89392948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.03079592
2MP0003806_abnormal_nucleotide_metabolis4.41880532
3MP0005670_abnormal_white_adipose3.87463172
4MP0003646_muscle_fatigue3.55905194
5MP0002837_dystrophic_cardiac_calcinosis3.38913184
6* MP0006036_abnormal_mitochondrial_physio2.85561323
7MP0004084_abnormal_cardiac_muscle2.68307654
8MP0005360_urolithiasis2.56680077
9* MP0003186_abnormal_redox_activity2.52061726
10MP0005464_abnormal_platelet_physiology2.34827191
11MP0000749_muscle_degeneration2.31743959
12MP0005332_abnormal_amino_acid2.27310994
13MP0005451_abnormal_body_composition2.23500144
14MP0002139_abnormal_hepatobiliary_system2.20762093
15MP0005666_abnormal_adipose_tissue2.18676049
16MP0000751_myopathy2.11978838
17MP0004036_abnormal_muscle_relaxation2.07738743
18MP0009840_abnormal_foam_cell1.97360457
19MP0004130_abnormal_muscle_cell1.97015829
20MP0004019_abnormal_vitamin_homeostasis1.95865867
21MP0000750_abnormal_muscle_regeneration1.91502775
22MP0003075_altered_response_to1.88076090
23MP0004043_abnormal_pH_regulation1.86281817
24MP0003698_abnormal_male_reproductive1.81087357
25MP0009643_abnormal_urine_homeostasis1.77993010
26MP0000003_abnormal_adipose_tissue1.74560591
27MP0005330_cardiomyopathy1.73385258
28MP0008875_abnormal_xenobiotic_pharmacok1.71747928
29MP0006035_abnormal_mitochondrial_morpho1.69987750
30MP0001929_abnormal_gametogenesis1.68675157
31MP0010030_abnormal_orbit_morphology1.68381156
32MP0003195_calcinosis1.66731571
33MP0002269_muscular_atrophy1.66690357
34MP0003172_abnormal_lysosome_physiology1.64761714
35MP0004215_abnormal_myocardial_fiber1.62407753
36MP0005319_abnormal_enzyme/_coenzyme1.58589387
37MP0008775_abnormal_heart_ventricle1.54958029
38MP0002132_abnormal_respiratory_system1.54883454
39MP0001756_abnormal_urination1.52370120
40MP0004233_abnormal_muscle_weight1.52087072
41MP0003329_amyloid_beta_deposits1.50582133
42MP0004272_abnormal_basement_membrane1.49913564
43MP0004510_myositis1.48847903
44MP0010329_abnormal_lipoprotein_level1.48636020
45MP0005165_increased_susceptibility_to1.47587326
46MP0003191_abnormal_cellular_cholesterol1.45919708
47MP0005636_abnormal_mineral_homeostasis1.45816076
48MP0005085_abnormal_gallbladder_physiolo1.45686910
49MP0000604_amyloidosis1.45597044
50MP0008438_abnormal_cutaneous_collagen1.44057806
51MP0004087_abnormal_muscle_fiber1.41213480
52MP0005365_abnormal_bile_salt1.40262597
53MP0005584_abnormal_enzyme/coenzyme_acti1.39374748
54MP0002653_abnormal_ependyma_morphology1.38987721
55MP0003011_delayed_dark_adaptation1.38295423
56MP0005083_abnormal_biliary_tract1.37283097
57MP0003878_abnormal_ear_physiology1.36384329
58MP0005377_hearing/vestibular/ear_phenot1.36384329
59MP0001764_abnormal_homeostasis1.34407082
60MP0002160_abnormal_reproductive_system1.33604888
61MP0003705_abnormal_hypodermis_morpholog1.31713254
62MP0000858_altered_metastatic_potential1.31226177
63MP0005058_abnormal_lysosome_morphology1.30630225
64MP0005266_abnormal_metabolism1.29998878
65MP0009379_abnormal_foot_pigmentation1.29238351
66MP0005375_adipose_tissue_phenotype1.28825991
67MP0000358_abnormal_cell_content/1.28343763
68MP0005385_cardiovascular_system_phenoty1.27254502
69MP0001544_abnormal_cardiovascular_syste1.27254502
70MP0003656_abnormal_erythrocyte_physiolo1.26969655
71MP0005257_abnormal_intraocular_pressure1.26745108
72MP0002118_abnormal_lipid_homeostasis1.26041461
73MP0004147_increased_porphyrin_level1.25602263
74MP0002332_abnormal_exercise_endurance1.23836290
75MP0002972_abnormal_cardiac_muscle1.22013920
76MP0000747_muscle_weakness1.20106752
77MP0000343_altered_response_to1.19485500
78MP0003221_abnormal_cardiomyocyte_apopto1.16759216
79MP0006138_congestive_heart_failure1.14627415
80MP0000681_abnormal_thyroid_gland1.14490240
81MP0005397_hematopoietic_system_phenotyp1.11354831
82MP0001545_abnormal_hematopoietic_system1.11354831
83MP0004185_abnormal_adipocyte_glucose1.11306056
84MP0003879_abnormal_hair_cell1.10214597
85MP0005620_abnormal_muscle_contractility1.10194183
86MP0001849_ear_inflammation1.09051083
87MP0005334_abnormal_fat_pad1.08025000
88MP0003303_peritoneal_inflammation1.06796455
89MP0002295_abnormal_pulmonary_circulatio1.05042112
90MP0002161_abnormal_fertility/fecundity1.01756770
91MP0002106_abnormal_muscle_physiology0.99879855
92MP0003123_paternal_imprinting0.99717986
93MP0001765_abnormal_ion_homeostasis0.99696973
94MP0003566_abnormal_cell_adhesion0.99421233
95MP0009333_abnormal_splenocyte_physiolog0.98935880
96MP0004858_abnormal_nervous_system0.98351262
97MP0000678_abnormal_parathyroid_gland0.97114589
98MP0010630_abnormal_cardiac_muscle0.96598570
99MP0003950_abnormal_plasma_membrane0.94619728
100MP0005275_abnormal_skin_tensile0.93777121
101MP0001881_abnormal_mammary_gland0.93249283
102MP0002210_abnormal_sex_determination0.92594622
103MP0005379_endocrine/exocrine_gland_phen0.92552303
104MP0000759_abnormal_skeletal_muscle0.92486080
105MP0002136_abnormal_kidney_physiology0.92475522
106MP0003959_abnormal_lean_body0.92272014
107MP0001145_abnormal_male_reproductive0.91806341
108MP0000609_abnormal_liver_physiology0.91297106
109MP0003693_abnormal_embryo_hatching0.90719304
110MP0005376_homeostasis/metabolism_phenot0.90671156
111MP0003453_abnormal_keratinocyte_physiol0.89900922
112MP0005501_abnormal_skin_physiology0.86276406
113MP0005535_abnormal_body_temperature0.85960446
114MP0001958_emphysema0.85403879
115MP0002971_abnormal_brown_adipose0.85012573
116MP0009115_abnormal_fat_cell0.84502013
117MP0002877_abnormal_melanocyte_morpholog0.82152315
118MP0001661_extended_life_span0.82085274
119MP0009780_abnormal_chondrocyte_physiolo0.79557709
120MP0003638_abnormal_response/metabolism_0.78136062
121MP0002078_abnormal_glucose_homeostasis0.77893609
122MP0004957_abnormal_blastocyst_morpholog0.77009373
123MP0000013_abnormal_adipose_tissue0.76890541
124MP0005167_abnormal_blood-brain_barrier0.76826690
125MP0001727_abnormal_embryo_implantation0.75782881
126MP0008874_decreased_physiological_sensi0.75718517
127MP0002148_abnormal_hypersensitivity_rea0.75400139
128MP0005369_muscle_phenotype0.74800386
129MP0004133_heterotaxia0.73860406
130MP0005166_decreased_susceptibility_to0.73529425
131MP0001853_heart_inflammation0.73179607
132MP0009278_abnormal_bone_marrow0.73031270
133MP0005448_abnormal_energy_balance0.72040150
134MP0009642_abnormal_blood_homeostasis0.71342470
135MP0008469_abnormal_protein_level0.70476320
136MP0002970_abnormal_white_adipose0.70233015
137MP0005623_abnormal_meninges_morphology0.68671061
138MP0005452_abnormal_adipose_tissue0.68328823
139MP0002254_reproductive_system_inflammat0.67457660
140MP0003718_maternal_effect0.66994505
141MP0002876_abnormal_thyroid_physiology0.66801443
142MP0000598_abnormal_liver_morphology0.66556645
143MP0000249_abnormal_blood_vessel0.66232929
144MP0008260_abnormal_autophagy0.65966131
145MP0000653_abnormal_sex_gland0.65519564
146MP0001542_abnormal_bone_strength0.64421817
147MP0001730_embryonic_growth_arrest0.63712767
148MP0003279_aneurysm0.63498740

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.05284793
2Abnormal mitochondria in muscle tissue (HP:0008316)4.02051816
3Acute encephalopathy (HP:0006846)3.93202092
4Myoglobinuria (HP:0002913)3.83196214
5Hepatic necrosis (HP:0002605)3.75065233
6Hyperglycinuria (HP:0003108)3.68539062
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66266894
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66266894
9Cerebral edema (HP:0002181)3.55629574
10Vertebral compression fractures (HP:0002953)3.55575021
11Rhabdomyolysis (HP:0003201)3.54614511
12Purpura (HP:0000979)3.54069279
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51240721
14Hepatocellular necrosis (HP:0001404)3.48058755
15Abnormality of fatty-acid metabolism (HP:0004359)3.41757291
16Mitochondrial inheritance (HP:0001427)3.32648373
17Abnormality of liposaccharide metabolism (HP:0010968)3.31981395
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.31981395
19Abnormality of glycolipid metabolism (HP:0010969)3.31981395
20Systemic lupus erythematosus (HP:0002725)3.31350266
21Absent/shortened dynein arms (HP:0200106)3.28889767
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.28889767
23Muscle fiber splitting (HP:0003555)3.25516507
24Renal Fanconi syndrome (HP:0001994)3.18041470
25Progressive macrocephaly (HP:0004481)3.15595734
26Gout (HP:0001997)3.15294527
27Dicarboxylic aciduria (HP:0003215)3.13755246
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.13755246
29Increased CSF lactate (HP:0002490)3.12089338
30Increased muscle lipid content (HP:0009058)3.10265942
31Xanthomatosis (HP:0000991)3.09309357
32Petechiae (HP:0000967)3.08043343
33Abnormality of glycine metabolism (HP:0010895)3.05462516
34Abnormality of serine family amino acid metabolism (HP:0010894)3.05462516
35Palpitations (HP:0001962)2.99046606
36Dysostosis multiplex (HP:0000943)2.96597605
37Exercise-induced muscle cramps (HP:0003710)2.93511320
38Lactic acidosis (HP:0003128)2.93481534
39Lethargy (HP:0001254)2.93427460
40Chronic bronchitis (HP:0004469)2.91200874
41Vacuolated lymphocytes (HP:0001922)2.84952502
42Hyperammonemia (HP:0001987)2.80143348
43Respiratory failure (HP:0002878)2.79235859
44Nuclear cataract (HP:0100018)2.78053604
45Hyporeflexia of lower limbs (HP:0002600)2.69594867
46Proximal tubulopathy (HP:0000114)2.68853830
47Generalized aminoaciduria (HP:0002909)2.68013008
48Nausea (HP:0002018)2.64773002
49Abnormality of the Achilles tendon (HP:0005109)2.64423572
50Multiple enchondromatosis (HP:0005701)2.62910285
51Acanthosis nigricans (HP:0000956)2.60700316
52Cholecystitis (HP:0001082)2.59632863
53Abnormal gallbladder physiology (HP:0012438)2.59632863
54Hepatosplenomegaly (HP:0001433)2.57192503
55Exercise intolerance (HP:0003546)2.56904703
56Abnormality of glycolysis (HP:0004366)2.56815266
57Increased serum pyruvate (HP:0003542)2.56815266
58Prolonged neonatal jaundice (HP:0006579)2.56806599
59Increased intramyocellular lipid droplets (HP:0012240)2.50342199
60Nasal polyposis (HP:0100582)2.49998093
61Sudden death (HP:0001699)2.49549997
62Ketosis (HP:0001946)2.47790373
63Hyperuricemia (HP:0002149)2.46578969
64Increased purine levels (HP:0004368)2.46578969
65Abnormality of the nasal mucosa (HP:0000433)2.45041534
66Distal lower limb muscle weakness (HP:0009053)2.43357585
67Achilles tendon contracture (HP:0001771)2.42287485
68Hyperlipoproteinemia (HP:0010980)2.39344878
69Vomiting (HP:0002013)2.39075212
70Leukodystrophy (HP:0002415)2.35972187
71Hyperglycinemia (HP:0002154)2.35954336
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35651010
73Abnormality of renal excretion (HP:0011036)2.33381570
74Ketoacidosis (HP:0001993)2.32288389
75Exercise-induced myalgia (HP:0003738)2.31686178
76Renal salt wasting (HP:0000127)2.31451296
77Complement deficiency (HP:0004431)2.31041973
78Abnormality of complement system (HP:0005339)2.29625945
79Myotonia (HP:0002486)2.28438923
80Increased serum lactate (HP:0002151)2.28135770
81Growth hormone excess (HP:0000845)2.27445503
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27369215
83Difficulty climbing stairs (HP:0003551)2.26385050
84Infertility (HP:0000789)2.24742123
85CNS demyelination (HP:0007305)2.24503395
86Progressive neurologic deterioration (HP:0002344)2.24488185
87Abnormal respiratory epithelium morphology (HP:0012253)2.23624351
88Abnormal respiratory motile cilium morphology (HP:0005938)2.23624351
89Hyperthyroidism (HP:0000836)2.23240125
90Ventricular tachycardia (HP:0004756)2.23221859
91Increased serum ferritin (HP:0003281)2.23133994
92Pheochromocytoma (HP:0002666)2.22800114
93Asymmetric septal hypertrophy (HP:0001670)2.21528408
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20498688
95Abnormal urine output (HP:0012590)2.20337740
96Testicular atrophy (HP:0000029)2.20003114
97Loss of speech (HP:0002371)2.19654038
98Lipoatrophy (HP:0100578)2.19109721
99Neuroendocrine neoplasm (HP:0100634)2.18846941
100Hypoglycemic coma (HP:0001325)2.18410624
101Protrusio acetabuli (HP:0003179)2.18218846
102Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17611251
103Abnormal respiratory motile cilium physiology (HP:0012261)2.16872437
104Muscle stiffness (HP:0003552)2.16464012
105Abnormality of cells of the erythroid lineage (HP:0012130)2.15687354
106Neoplasm of head and neck (HP:0012288)2.15439866
107Esophageal neoplasm (HP:0100751)2.15439866
108Polyuria (HP:0000103)2.15278919
109Abnormality of polysaccharide metabolism (HP:0011012)2.15211152
110Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15211152
111Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15211152
112Myocardial infarction (HP:0001658)2.14642101
113Amyloidosis (HP:0011034)2.13592918
114Stridor (HP:0010307)2.13254992
115Insulin resistance (HP:0000855)2.12418175
116Abnormality of purine metabolism (HP:0004352)2.09142879
117Glycosuria (HP:0003076)2.08940476
118Abnormality of urine glucose concentration (HP:0011016)2.08940476
119Oligomenorrhea (HP:0000876)2.06976659
120Hypokalemic alkalosis (HP:0001949)2.06749104
121Generalized muscle weakness (HP:0003324)2.06360182
122Conjunctival hamartoma (HP:0100780)2.06286642
123Lipid accumulation in hepatocytes (HP:0006561)2.06181729
124Rhinitis (HP:0012384)2.05385290
125Menorrhagia (HP:0000132)2.05147708
126Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04483771
127Increased connective tissue (HP:0009025)2.03119768
128Methylmalonic aciduria (HP:0012120)2.01588995
129Increased hepatocellular lipid droplets (HP:0006565)1.99746483
130Mucopolysacchariduria (HP:0008155)1.99515810
131Urinary glycosaminoglycan excretion (HP:0003541)1.99515810
132Progressive muscle weakness (HP:0003323)1.98891636
133Opisthotonus (HP:0002179)1.98490808
134Right ventricular cardiomyopathy (HP:0011663)1.98323515
135Rough bone trabeculation (HP:0100670)1.97141755
136Ragged-red muscle fibers (HP:0003200)1.96334810
137Metabolic acidosis (HP:0001942)1.95515274
138Deep venous thrombosis (HP:0002625)1.94757986
139Optic disc pallor (HP:0000543)1.92867502
140Emotional lability (HP:0000712)1.91889567
141Exertional dyspnea (HP:0002875)1.90620931
142Hypoalphalipoproteinemia (HP:0003233)1.89965267
143Hypertensive crisis (HP:0100735)1.89522681
144Atelectasis (HP:0100750)1.89429565
145Axonal loss (HP:0003447)1.88407592
146Hypertriglyceridemia (HP:0002155)1.88001887
147Fasciculations (HP:0002380)1.86816989
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85729173
149Cholelithiasis (HP:0001081)1.84376632
150Upper limb amyotrophy (HP:0009129)1.83559605
151Distal upper limb amyotrophy (HP:0007149)1.83559605
152Abnormality of serum amino acid levels (HP:0003112)1.83096564
153Hypercholesterolemia (HP:0003124)1.81629270
154Hemorrhage of the eye (HP:0011885)1.81309493
155Glomerulonephritis (HP:0000099)1.80485902
156Cervical subluxation (HP:0003308)1.79999377
157Retinal atrophy (HP:0001105)1.79317759
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79263050
159Cerebral palsy (HP:0100021)1.77914136
160Polygenic inheritance (HP:0010982)1.74711869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.77447919
2PDK45.77447919
3TESK15.09301210
4PDK24.10644672
5BCKDK3.57342823
6VRK23.40971605
7NME23.16640185
8IRAK32.79433809
9NEK12.76318550
10WNK42.18513009
11ARAF2.02079409
12TESK22.01776133
13TRIB31.97016828
14SMG11.86214803
15TAOK21.84594849
16LMTK21.77412946
17PRKD31.76603307
18EPHA21.73193222
19MYLK1.70918665
20BUB11.67730276
21MAPKAPK31.65143106
22PINK11.54859441
23TTN1.53567587
24PIM21.50334865
25LIMK11.48329986
26ICK1.38785629
27EPHB21.38705188
28WEE11.36763368
29PKN21.28428717
30MAP3K111.19829549
31DAPK11.19417349
32DDR21.19074004
33PTK2B1.17165097
34PAK41.14824760
35BMX1.14350912
36LRRK21.11143588
37BRAF1.09790558
38EIF2AK11.09257496
39OBSCN1.07490790
40STK391.02611532
41STK381.01758402
42DAPK31.01220471
43ILK0.97466358
44PRPF4B0.96873620
45NEK20.95577177
46STK38L0.94078406
47RPS6KB20.92565794
48ERN10.87299491
49GRK50.86177651
50WNK30.84378672
51MAP3K120.83165462
52KDR0.81388030
53TIE10.81154779
54MAP2K30.80677072
55MAP3K30.80390293
56ABL20.78188527
57SCYL20.77063775
58NME10.76801355
59MST1R0.76793588
60PAK10.73693124
61PHKG10.69933170
62PHKG20.69933170
63PDPK10.67378147
64MET0.67238576
65MAP3K10.66900103
66MAP2K20.64700006
67PTK20.62417871
68PDK10.61460420
69OXSR10.61234367
70CSNK1G30.61010702
71FLT30.60084559
72TTK0.59507684
73MOS0.57764007
74AURKA0.55655719
75PRKG20.55354409
76AKT20.54497900
77MAP3K80.54096690
78TAOK10.48913197
79CAMK1D0.48205506
80KSR20.47703345
81MAP2K10.47332951
82MUSK0.47264876
83CDK80.46347682
84DYRK30.45134416
85CDK11A0.43870521
86STK160.42836759
87CDK140.41561867
88NEK90.41349829
89DYRK1B0.41193435
90MST40.39018277
91MAPK110.38833783
92IKBKB0.38427138
93VRK10.37283899
94CDK150.36208201
95PLK40.36170703
96PKN10.35770065
97PRKCI0.35700274
98RIPK40.34910103
99TGFBR20.34843423
100CDC42BPA0.34579404
101CAMK2G0.34166300
102MAPK40.33694353
103CAMKK20.32682040
104CDK180.30883150
105ZAK0.30380877
106EIF2AK30.30341142
107PRKD20.29987979
108TYK20.29646408
109PBK0.29169948
110HIPK20.28886039
111MAPKAPK50.28669710
112CDK90.28571548
113SIK10.28550675
114PRKAA20.27931706
115GSK3A0.27386757
116RAF10.26027621
117EEF2K0.25848381
118PAK20.25781074
119IRAK20.25200095
120TLK10.24803453
121PAK60.24603938
122MAP2K60.24568186
123CSNK1A1L0.24038132
124PLK10.23817162
125FER0.23020297
126RPS6KA50.22587843
127CSNK2A10.21715563
128BRSK20.21494631
129STK40.21437254
130PIM10.19468698
131LATS20.19160606
132RIPK10.18461717
133PRKACG0.18400453
134RPS6KL10.18288932
135RPS6KC10.18288932
136CAMK2D0.16612435
137RPS6KA60.15915959
138CCNB10.15519172
139CSNK2A20.15467490
140TBK10.15185050
141PRKCD0.14997341
142BRSK10.14672630
143PRKD10.14627257

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.12318362
2Oxidative phosphorylation_Homo sapiens_hsa001903.34584111
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25201180
4Propanoate metabolism_Homo sapiens_hsa006403.18381859
5Pyruvate metabolism_Homo sapiens_hsa006203.07512847
6Parkinsons disease_Homo sapiens_hsa050123.03868049
7Carbon metabolism_Homo sapiens_hsa012002.64408291
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56711770
9Proteasome_Homo sapiens_hsa030502.42295874
10Fatty acid degradation_Homo sapiens_hsa000712.32704068
11Huntingtons disease_Homo sapiens_hsa050162.29788303
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.29727203
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16562633
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10799683
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98862917
16Alzheimers disease_Homo sapiens_hsa050101.93719164
17Cardiac muscle contraction_Homo sapiens_hsa042601.92991597
18Fatty acid metabolism_Homo sapiens_hsa012121.90582389
19Biosynthesis of amino acids_Homo sapiens_hsa012301.82548698
20Ribosome_Homo sapiens_hsa030101.81704925
21PPAR signaling pathway_Homo sapiens_hsa033201.68508339
22Pentose phosphate pathway_Homo sapiens_hsa000301.62187906
23Sulfur relay system_Homo sapiens_hsa041221.53665916
24Fructose and mannose metabolism_Homo sapiens_hsa000511.52671106
25Peroxisome_Homo sapiens_hsa041461.47532045
26* Glutathione metabolism_Homo sapiens_hsa004801.45155416
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.40122312
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37623214
29Vitamin B6 metabolism_Homo sapiens_hsa007501.35675704
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30220579
31Fatty acid biosynthesis_Homo sapiens_hsa000611.28073450
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26463182
33Butanoate metabolism_Homo sapiens_hsa006501.26348014
34beta-Alanine metabolism_Homo sapiens_hsa004101.24425401
35Phenylalanine metabolism_Homo sapiens_hsa003601.17838797
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16535830
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15731602
38Collecting duct acid secretion_Homo sapiens_hsa049661.15599519
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13026826
40Selenocompound metabolism_Homo sapiens_hsa004501.11019911
41Folate biosynthesis_Homo sapiens_hsa007901.10030116
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09108777
43Fatty acid elongation_Homo sapiens_hsa000621.06907191
44Glycerolipid metabolism_Homo sapiens_hsa005611.03365262
45Complement and coagulation cascades_Homo sapiens_hsa046101.02960709
46Chemical carcinogenesis_Homo sapiens_hsa052041.00084049
47Tryptophan metabolism_Homo sapiens_hsa003800.99133513
48Pyrimidine metabolism_Homo sapiens_hsa002400.94915992
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94224157
50Arginine biosynthesis_Homo sapiens_hsa002200.93681932
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.93232157
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93160078
53Fat digestion and absorption_Homo sapiens_hsa049750.92421105
54Tyrosine metabolism_Homo sapiens_hsa003500.90311977
55Synaptic vesicle cycle_Homo sapiens_hsa047210.90114601
56Arginine and proline metabolism_Homo sapiens_hsa003300.89653465
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.88743442
58Metabolic pathways_Homo sapiens_hsa011000.88333649
59Sulfur metabolism_Homo sapiens_hsa009200.87523058
60Base excision repair_Homo sapiens_hsa034100.86104634
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83842282
62DNA replication_Homo sapiens_hsa030300.82486190
63RNA polymerase_Homo sapiens_hsa030200.77175093
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75799150
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75703978
66Galactose metabolism_Homo sapiens_hsa000520.74681808
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70608265
68Prion diseases_Homo sapiens_hsa050200.70563686
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.70320031
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68362199
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68138075
72N-Glycan biosynthesis_Homo sapiens_hsa005100.67928517
73Starch and sucrose metabolism_Homo sapiens_hsa005000.67212837
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65021152
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62787959
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62019780
77Purine metabolism_Homo sapiens_hsa002300.58870114
78Nitrogen metabolism_Homo sapiens_hsa009100.56712810
79Arachidonic acid metabolism_Homo sapiens_hsa005900.55803188
80Linoleic acid metabolism_Homo sapiens_hsa005910.55235469
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54714220
82Histidine metabolism_Homo sapiens_hsa003400.51399763
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50103380
84Caffeine metabolism_Homo sapiens_hsa002320.47168723
85Glucagon signaling pathway_Homo sapiens_hsa049220.45371599
86Steroid biosynthesis_Homo sapiens_hsa001000.44539584
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44137161
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.43819188
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.43415575
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42512273
91Vitamin digestion and absorption_Homo sapiens_hsa049770.41106718
92Vibrio cholerae infection_Homo sapiens_hsa051100.40733173
93Mismatch repair_Homo sapiens_hsa034300.40452958
94Bile secretion_Homo sapiens_hsa049760.40425505
95Sphingolipid metabolism_Homo sapiens_hsa006000.38437001
96RNA transport_Homo sapiens_hsa030130.38162708
97Retinol metabolism_Homo sapiens_hsa008300.36374561
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.33940396
99Mineral absorption_Homo sapiens_hsa049780.33222221
100Nucleotide excision repair_Homo sapiens_hsa034200.33086714
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.31738755
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31625681
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30451178
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29813894
105Systemic lupus erythematosus_Homo sapiens_hsa053220.28258817
106One carbon pool by folate_Homo sapiens_hsa006700.28124987
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27395576
108Lysosome_Homo sapiens_hsa041420.27026891
109AMPK signaling pathway_Homo sapiens_hsa041520.26410618
110Other glycan degradation_Homo sapiens_hsa005110.25922338
111Shigellosis_Homo sapiens_hsa051310.25881128
112Regulation of autophagy_Homo sapiens_hsa041400.25367635
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.25314381
114HIF-1 signaling pathway_Homo sapiens_hsa040660.25025629
115Renin-angiotensin system_Homo sapiens_hsa046140.23677527
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23395152
117Salmonella infection_Homo sapiens_hsa051320.22372609
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22229292
119Endocytosis_Homo sapiens_hsa041440.22121678

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