GPX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.09665966
2single fertilization (GO:0007338)8.60292132
3indole-containing compound catabolic process (GO:0042436)8.57867698
4indolalkylamine catabolic process (GO:0046218)8.57867698
5tryptophan catabolic process (GO:0006569)8.57867698
6heterotypic cell-cell adhesion (GO:0034113)8.54034023
7positive regulation of type 2 immune response (GO:0002830)7.45082099
8tryptophan metabolic process (GO:0006568)7.37489141
9negative regulation of interleukin-10 production (GO:0032693)7.36545838
10aromatic amino acid family catabolic process (GO:0009074)5.88510561
11fertilization (GO:0009566)5.67490275
12amine catabolic process (GO:0009310)5.52318649
13cellular biogenic amine catabolic process (GO:0042402)5.52318649
14indolalkylamine metabolic process (GO:0006586)5.41793661
15negative regulation of interleukin-8 production (GO:0032717)5.24932900
16benzene-containing compound metabolic process (GO:0042537)4.83101880
17digestion (GO:0007586)4.62921570
18epithelial cell morphogenesis (GO:0003382)4.37993970
19negative regulation of T cell apoptotic process (GO:0070233)4.37316455
20negative regulation of endopeptidase activity (GO:0010951)4.35105245
21positive regulation of cell-cell adhesion (GO:0022409)4.32025335
22aromatic amino acid family metabolic process (GO:0009072)4.25999863
23negative regulation of peptidase activity (GO:0010466)4.15343500
24transepithelial transport (GO:0070633)3.96823747
25regulation of type 2 immune response (GO:0002828)3.88535883
26indole-containing compound metabolic process (GO:0042430)3.87698190
27regulation of clathrin-mediated endocytosis (GO:2000369)3.78040420
28reverse cholesterol transport (GO:0043691)3.70076814
29sulfur amino acid catabolic process (GO:0000098)3.60188755
30defense response to bacterium (GO:0042742)3.53754504
31N-acetylneuraminate metabolic process (GO:0006054)3.41136928
32negative regulation of protein autophosphorylation (GO:0031953)3.34330332
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31762475
34phospholipid homeostasis (GO:0055091)3.22892448
35alpha-linolenic acid metabolic process (GO:0036109)3.13407905
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11227138
37response to bacterium (GO:0009617)3.05829780
38regulation of macrophage activation (GO:0043030)3.01322694
39seminiferous tubule development (GO:0072520)25.0875312
40regulation of lipoprotein metabolic process (GO:0050746)2.98785132
41negative regulation of proteolysis (GO:0045861)2.80924782
42glial cell proliferation (GO:0014009)2.80260632
43cysteine metabolic process (GO:0006534)2.76711354
44regulation of beta-amyloid formation (GO:1902003)2.73965910
45sialylation (GO:0097503)2.72698915
46complement activation, alternative pathway (GO:0006957)2.72107807
47regulation of activated T cell proliferation (GO:0046006)2.72005098
48negative regulation of glycogen biosynthetic process (GO:0045719)2.72004490
49negative regulation of protein processing (GO:0010955)2.70975262
50negative regulation of protein maturation (GO:1903318)2.70975262
51O-glycan processing (GO:0016266)2.69127505
52high-density lipoprotein particle remodeling (GO:0034375)2.67445208
53negative regulation of lymphocyte apoptotic process (GO:0070229)2.67216364
54positive regulation of cellular amide metabolic process (GO:0034250)2.64018843
55low-density lipoprotein particle clearance (GO:0034383)2.57990685
56positive regulation of interleukin-12 production (GO:0032735)2.55306815
57columnar/cuboidal epithelial cell development (GO:0002066)2.52617413
58hormone catabolic process (GO:0042447)2.52163067
59negative regulation of hydrolase activity (GO:0051346)2.51984349
60negative regulation of receptor-mediated endocytosis (GO:0048261)2.48172614
61regulation of amyloid precursor protein catabolic process (GO:1902991)2.47313654
62negative regulation of glycogen metabolic process (GO:0070874)2.46400829
63L-serine transport (GO:0015825)2.37006334
64alpha-amino acid catabolic process (GO:1901606)2.33743633
65valine metabolic process (GO:0006573)2.33420665
66regulation of endopeptidase activity (GO:0052548)2.32994037
67lipid catabolic process (GO:0016042)2.31486458
68pyrimidine ribonucleoside catabolic process (GO:0046133)2.30345740
69cellular amino acid catabolic process (GO:0009063)2.26106048
70negative regulation of interleukin-6 production (GO:0032715)2.25215620
71triglyceride catabolic process (GO:0019433)2.24675130
72response to misfolded protein (GO:0051788)2.23661586
73regulation of T cell apoptotic process (GO:0070232)2.22307992
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.22246236
75L-phenylalanine catabolic process (GO:0006559)2.22246236
76regulation of peptidase activity (GO:0052547)2.21376585
77acylglycerol catabolic process (GO:0046464)2.18529586
78neutral lipid catabolic process (GO:0046461)2.18529586
79protein-lipid complex remodeling (GO:0034368)2.15931124
80macromolecular complex remodeling (GO:0034367)2.15931124
81plasma lipoprotein particle remodeling (GO:0034369)2.15931124
82positive regulation of sterol transport (GO:0032373)2.10888588
83positive regulation of cholesterol transport (GO:0032376)2.10888588
84Golgi transport vesicle coating (GO:0048200)2.10369367
85COPI coating of Golgi vesicle (GO:0048205)2.10369367
86regulation of interleukin-10 production (GO:0032653)2.09270429
87cellular modified amino acid catabolic process (GO:0042219)2.08064498
88myelin maintenance (GO:0043217)2.07579679
89cellular response to epidermal growth factor stimulus (GO:0071364)2.07260142
90glutamate metabolic process (GO:0006536)2.06998377
91negative regulation of T cell proliferation (GO:0042130)2.05295502
92serine transport (GO:0032329)2.04926382
93activation of protein kinase A activity (GO:0034199)2.03779174
94regulation of reproductive process (GO:2000241)2.00083701
95regulation of T cell tolerance induction (GO:0002664)14.3540839
96production of molecular mediator involved in inflammatory response (GO:0002532)14.3463474
97positive regulation of tolerance induction (GO:0002645)12.3123729
98sperm capacitation (GO:0048240)11.1635125
99regulation of tolerance induction (GO:0002643)10.7156735
100kynurenine metabolic process (GO:0070189)10.4825669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.74864766
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.19847524
3IKZF1_21737484_ChIP-ChIP_HCT116_Human4.02533766
4AR_21572438_ChIP-Seq_LNCaP_Human3.21169130
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.15477988
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.63748077
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.59990859
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58766548
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.54364141
10ZNF263_19887448_ChIP-Seq_K562_Human2.50798916
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45519226
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.35697332
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.32144071
14DNAJC2_21179169_ChIP-ChIP_NT2_Human2.19234983
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.11085871
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.06205383
17SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.05571174
18CLOCK_20551151_ChIP-Seq_293T_Human1.99591531
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88959187
20GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.84293346
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79785954
22GATA3_21867929_ChIP-Seq_TH1_Mouse1.75234413
23PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68138554
24NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.67660148
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67553093
26SMAD1_18555785_Chip-Seq_ESCs_Mouse1.63908577
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.62802785
28REST_19997604_ChIP-ChIP_NEURONS_Mouse1.59024742
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57309713
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55869247
31FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53120534
32SMAD4_21741376_ChIP-Seq_HESCs_Human1.52895519
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52044333
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52044333
35STAT1_17558387_ChIP-Seq_HELA_Human1.48252412
36RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47988713
37FLI1_21867929_ChIP-Seq_CD8_Mouse1.47073668
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46482983
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44397159
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39509305
41ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38824423
42SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38444862
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.34026903
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31596225
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31505702
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.29648558
47P68_20966046_ChIP-Seq_HELA_Human1.24054434
48CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23015074
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18299581
50RACK7_27058665_Chip-Seq_MCF-7_Human1.16732701
51VDR_24787735_ChIP-Seq_THP-1_Human1.16523053
52CTCF_18555785_Chip-Seq_ESCs_Mouse1.16480873
53SMC4_20622854_ChIP-Seq_HELA_Human1.15692730
54MYC_27129775_Chip-Seq_CORNEA_Mouse1.15580585
55JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13334310
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11736273
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10546613
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10203608
59SALL4_22934838_ChIP-ChIP_CD34+_Human1.08347758
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06697646
61MYC_19915707_ChIP-ChIP_AK7_Human1.06326379
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.05940548
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05438384
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04658584
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03720864
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03174645
67FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02685739
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.00136102
69ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99869246
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99230574
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99103393
72BCL6_27268052_Chip-Seq_Bcells_Human0.98371113
73FOXH1_21741376_ChIP-Seq_ESCs_Human0.98359192
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97994190
75DROSHA_22980978_ChIP-Seq_HELA_Human0.97198256
76TP53_20018659_ChIP-ChIP_R1E_Mouse0.95321730
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94990695
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94380677
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93756567
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.93657580
81KDM2B_26808549_Chip-Seq_REH_Human0.93542100
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93328460
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.92611330
84KDM2B_26808549_Chip-Seq_K562_Human0.91310990
85LXR_22292898_ChIP-Seq_THP-1_Human0.91028361
86* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89253065
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.89088832
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88573044
89P300_27268052_Chip-Seq_Bcells_Human0.86999964
90GATA1_19941826_ChIP-Seq_K562_Human0.86768635
91SOX2_18555785_Chip-Seq_ESCs_Mouse0.86592048
92BCOR_27268052_Chip-Seq_Bcells_Human0.85513524
93SOX2_20726797_ChIP-Seq_SW620_Human0.84884436
94RAC3_21632823_ChIP-Seq_H3396_Human0.84469668
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84098842
96WT1_19549856_ChIP-ChIP_CCG9911_Human0.81958416
97RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80648051
98OCT4_20526341_ChIP-Seq_ESCs_Human0.80245342
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77694106
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77694106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.72325437
2MP0003195_calcinosis5.17683526
3MP0002254_reproductive_system_inflammat4.95286395
4MP0004043_abnormal_pH_regulation4.69808874
5MP0010234_abnormal_vibrissa_follicle4.23175766
6MP0002139_abnormal_hepatobiliary_system4.20432971
7MP0005410_abnormal_fertilization3.30890894
8MP0005058_abnormal_lysosome_morphology3.17513206
9MP0003329_amyloid_beta_deposits3.05899385
10MP0000003_abnormal_adipose_tissue2.20224795
11MP0005360_urolithiasis2.18461216
12MP0000604_amyloidosis2.09335659
13MP0010329_abnormal_lipoprotein_level2.07283541
14MP0002168_other_aberrant_phenotype2.00408111
15MP0005365_abnormal_bile_salt1.85845427
16MP0003300_gastrointestinal_ulcer1.78528218
17MP0003566_abnormal_cell_adhesion1.77203663
18MP0004885_abnormal_endolymph1.67750223
19MP0001501_abnormal_sleep_pattern1.60524438
20MP0005085_abnormal_gallbladder_physiolo1.60073559
21MP0004130_abnormal_muscle_cell1.58001723
22MP0001765_abnormal_ion_homeostasis1.53476525
23MP0004859_abnormal_synaptic_plasticity1.53373992
24MP0005375_adipose_tissue_phenotype1.53362238
25MP0002837_dystrophic_cardiac_calcinosis1.53251558
26MP0001440_abnormal_grooming_behavior1.48122075
27MP0001853_heart_inflammation1.42919309
28MP0003690_abnormal_glial_cell1.39789019
29MP0000534_abnormal_ureter_morphology1.38162284
30MP0004858_abnormal_nervous_system1.35718114
31MP0009643_abnormal_urine_homeostasis1.35483491
32MP0003705_abnormal_hypodermis_morpholog1.33088537
33MP0005332_abnormal_amino_acid1.29543454
34MP0004185_abnormal_adipocyte_glucose1.29308500
35MP0005083_abnormal_biliary_tract1.27763903
36MP0008438_abnormal_cutaneous_collagen1.20484082
37MP0002118_abnormal_lipid_homeostasis1.19411226
38MP0002089_abnormal_postnatal_growth/wei1.17967912
39MP0005584_abnormal_enzyme/coenzyme_acti1.16352132
40MP0001756_abnormal_urination1.15186554
41MP0000537_abnormal_urethra_morphology1.14984982
42MP0005275_abnormal_skin_tensile1.11124793
43MP0002896_abnormal_bone_mineralization1.07446129
44MP0003806_abnormal_nucleotide_metabolis1.07073308
45MP0003191_abnormal_cellular_cholesterol1.06928559
46MP0004270_analgesia1.06272787
47MP0003252_abnormal_bile_duct1.06129428
48MP0002796_impaired_skin_barrier1.03991891
49MP0009780_abnormal_chondrocyte_physiolo1.01819529
50MP0005636_abnormal_mineral_homeostasis0.99476586
51MP0003075_altered_response_to0.97013743
52MP0008875_abnormal_xenobiotic_pharmacok0.96463906
53MP0002909_abnormal_adrenal_gland0.96172959
54MP0003632_abnormal_nervous_system0.95996406
55MP0005666_abnormal_adipose_tissue0.94592557
56MP0000920_abnormal_myelination0.93977565
57MP0003879_abnormal_hair_cell0.89078139
58MP0002733_abnormal_thermal_nociception0.85769269
59MP0002136_abnormal_kidney_physiology0.83663934
60MP0000747_muscle_weakness0.81427026
61MP0002933_joint_inflammation0.81185181
62MP0004145_abnormal_muscle_electrophysio0.80621241
63MP0000609_abnormal_liver_physiology0.78932079
64MP0003635_abnormal_synaptic_transmissio0.78667116
65MP0003631_nervous_system_phenotype0.77755633
66MP0004036_abnormal_muscle_relaxation0.77241435
67MP0002876_abnormal_thyroid_physiology0.76395791
68MP0003633_abnormal_nervous_system0.75724878
69MP0005319_abnormal_enzyme/_coenzyme0.72776009
70MP0002735_abnormal_chemical_nociception0.71985578
71MP0005395_other_phenotype0.69883651
72MP0005670_abnormal_white_adipose0.69485706
73MP0009840_abnormal_foam_cell0.68972049
74MP0005535_abnormal_body_temperature0.64843842
75MP0010678_abnormal_skin_adnexa0.64046857
76MP0009384_cardiac_valve_regurgitation0.64017714
77MP0000538_abnormal_urinary_bladder0.63990401
78MP0002272_abnormal_nervous_system0.63779403
79MP0003634_abnormal_glial_cell0.63715588
80MP0005334_abnormal_fat_pad0.63561035
81MP0000462_abnormal_digestive_system0.61994621
82MP0005623_abnormal_meninges_morphology0.61494075
83MP0002295_abnormal_pulmonary_circulatio0.61052092
84MP0001970_abnormal_pain_threshold0.60467431
85MP0000249_abnormal_blood_vessel0.60174591
86MP0001666_abnormal_nutrient_absorption0.59748881
87MP0002971_abnormal_brown_adipose0.59708632
88MP0004272_abnormal_basement_membrane0.57251656
89MP0000751_myopathy0.57185711
90MP0009053_abnormal_anal_canal0.56352921
91MP0002064_seizures0.55469725
92MP0005166_decreased_susceptibility_to0.54650712
93MP0002653_abnormal_ependyma_morphology0.53033620
94MP0000013_abnormal_adipose_tissue0.52761069
95MP0003959_abnormal_lean_body0.52286648
96MP0002138_abnormal_hepatobiliary_system0.51468059
97MP0004087_abnormal_muscle_fiber0.50474994
98MP0001177_atelectasis0.50286453
99MP0005164_abnormal_response_to0.48270717
100MP0006138_congestive_heart_failure0.47628528

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.39158966
2Hypophosphatemic rickets (HP:0004912)5.08112744
3Facial shape deformation (HP:0011334)4.76611636
4Potter facies (HP:0002009)4.76611636
5Vascular calcification (HP:0004934)4.72565970
6Complement deficiency (HP:0004431)4.61226437
7Cardiovascular calcification (HP:0011915)4.40667871
8Neurofibrillary tangles (HP:0002185)4.32804634
9Cerebral inclusion bodies (HP:0100314)4.20135081
10Malnutrition (HP:0004395)3.95569734
11Choroideremia (HP:0001139)3.73223884
12Neoplasm of the heart (HP:0100544)3.56326591
13Abnormality of complement system (HP:0005339)3.35848763
14Recurrent gram-negative bacterial infections (HP:0005420)3.22557570
15Infantile muscular hypotonia (HP:0008947)3.21094728
16Supranuclear gaze palsy (HP:0000605)3.19991933
17Widely patent fontanelles and sutures (HP:0004492)3.19299610
18Xanthomatosis (HP:0000991)3.17758511
19Intention tremor (HP:0002080)3.15441432
20Rickets (HP:0002748)3.13823690
21Deep venous thrombosis (HP:0002625)3.11832717
22Agitation (HP:0000713)3.04244352
23Choreoathetosis (HP:0001266)3.02939547
24Hemiplegia (HP:0002301)2.75597891
25Ketoacidosis (HP:0001993)2.70552708
26Ketosis (HP:0001946)2.50340063
27Abnormality of the fovea (HP:0000493)2.47559921
28Intrahepatic cholestasis (HP:0001406)2.44805197
29Difficulty running (HP:0009046)2.43301760
30Polar cataract (HP:0010696)2.43233862
31Hemorrhage of the eye (HP:0011885)2.37535206
32Gout (HP:0001997)2.36903251
33Vacuolated lymphocytes (HP:0001922)2.35784327
34Hypopigmentation of the fundus (HP:0007894)2.35781572
35Skin nodule (HP:0200036)2.30786027
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29285105
37Hyporeflexia of lower limbs (HP:0002600)2.26325444
38Testicular atrophy (HP:0000029)2.26094208
39Acanthosis nigricans (HP:0000956)2.24915835
40Hyperglycinuria (HP:0003108)2.24837633
41Abnormality of purine metabolism (HP:0004352)2.19452472
42Peripheral hypomyelination (HP:0007182)2.19251497
43Abnormal hemoglobin (HP:0011902)2.17997667
44Epidermoid cyst (HP:0200040)2.14600553
45Gait ataxia (HP:0002066)2.10477046
46Osteomalacia (HP:0002749)2.10255439
47Hyperlipoproteinemia (HP:0010980)2.09542931
48Hepatoblastoma (HP:0002884)2.03384174
49Thin bony cortex (HP:0002753)2.02884570
50Focal segmental glomerulosclerosis (HP:0000097)2.02137759
51Abnormal rod and cone electroretinograms (HP:0008323)2.01623910
52Spastic diplegia (HP:0001264)1.99572755
53Abnormality of glycine metabolism (HP:0010895)1.99514603
54Abnormality of serine family amino acid metabolism (HP:0010894)1.99514603
55Myokymia (HP:0002411)1.98466664
56Ulnar claw (HP:0001178)1.96358873
57Right ventricular cardiomyopathy (HP:0011663)1.96285841
58Hyperparathyroidism (HP:0000843)1.96019084
59Segmental peripheral demyelination/remyelination (HP:0003481)1.91643741
60Muscle fiber splitting (HP:0003555)1.89214473
61Dysostosis multiplex (HP:0000943)1.88259394
62Increased connective tissue (HP:0009025)1.88013419
63Hypertriglyceridemia (HP:0002155)1.86738563
64Ectopia lentis (HP:0001083)1.86585318
65Systemic lupus erythematosus (HP:0002725)1.86342449
66Wide cranial sutures (HP:0010537)1.85878866
67Hyperammonemia (HP:0001987)1.85574156
68Hypoalphalipoproteinemia (HP:0003233)1.85084171
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81856159
70Degeneration of the lateral corticospinal tracts (HP:0002314)1.81856159
71Restlessness (HP:0000711)1.81599985
72Hyperphosphatemia (HP:0002905)1.81353424
73Prominent nose (HP:0000448)1.80959194
74Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79754615
75Hypophosphatemia (HP:0002148)1.78613321
76Glomerulosclerosis (HP:0000096)1.76831936
77Gastrointestinal dysmotility (HP:0002579)1.76311634
78Psychosis (HP:0000709)1.74332545
79Increased CSF protein (HP:0002922)1.72234523
80Turricephaly (HP:0000262)1.71434879
81Bony spicule pigmentary retinopathy (HP:0007737)1.71229878
82Oligomenorrhea (HP:0000876)1.70450401
83Progressive neurologic deterioration (HP:0002344)1.69335610
84Amyloidosis (HP:0011034)1.67384078
85Pili torti (HP:0003777)1.66696809
86Tubulointerstitial fibrosis (HP:0005576)1.66577288
87Abnormality of the periventricular white matter (HP:0002518)1.65005901
88Abnormal cartilage morphology (HP:0002763)1.63336512
89Abnormality of the Achilles tendon (HP:0005109)1.62329039
90Calf muscle hypertrophy (HP:0008981)1.62107411
91Hyperglycinemia (HP:0002154)1.60832828
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.60409186
93Back pain (HP:0003418)1.60073833
94Abnormality of transition element cation homeostasis (HP:0011030)1.58600131
95Abnormality of abdominal situs (HP:0011620)1.58203492
96Abdominal situs inversus (HP:0003363)1.58203492
97Subcapsular cataract (HP:0000523)1.57964115
98Prominent forehead (HP:0011220)1.57588112
99Abnormality of the corticospinal tract (HP:0002492)1.56452016
100Loss of speech (HP:0002371)1.56410244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.67720564
2ERN13.28298596
3LMTK23.18224352
4EPHB12.83621463
5SIK12.66334261
6PKN22.54605839
7LRRK22.33129186
8PDGFRA2.18429370
9TRIB32.16490712
10FGFR22.15370108
11FER2.14070747
12FGFR41.93672206
13TAOK31.87328074
14STK391.84303841
15WNK41.82418201
16PRKD31.82091366
17MAP3K21.57041699
18PTK61.49587217
19EPHA21.44176449
20TNK21.42737003
21NTRK31.38558317
22TTN1.38332635
23RET1.36655387
24TYRO31.30816732
25PTK2B1.29246668
26NTRK11.27315040
27PAK31.25171188
28RIPK41.23451463
29PTK21.19008846
30MAP2K41.16705615
31MYLK1.14551326
32INSR1.12148717
33PRKCH1.10184761
34SCYL21.09479233
35PAK61.09024448
36KSR21.08998144
37CDK191.08441107
38STK101.07410307
39TESK11.07063380
40FRK1.01077502
41BCKDK1.00747459
42FGFR30.96915221
43DMPK0.90525031
44MAP3K70.90481845
45LATS20.89957718
46EPHB20.84308132
47PAK40.83127550
48CDK50.82634011
49ICK0.82621905
50ALK0.81328724
51PAK20.81040070
52SIK20.80688204
53EPHA40.80106368
54MAP3K60.77609351
55MAP3K120.77439718
56PDK40.73866810
57PDK30.73866810
58MAP2K10.72899001
59WNK10.72521670
60NTRK20.71748134
61PHKG20.70162691
62PHKG10.70162691
63MINK10.69969937
64CAMK1G0.69247484
65PRKCG0.69017763
66DDR20.67578697
67DAPK20.66258874
68GSK3A0.65932207
69JAK20.65222571
70FLT30.64039564
71STK380.63994514
72FGFR10.62744079
73ROCK20.62629293
74LATS10.61550417
75SRC0.60872319
76PDGFRB0.59582495
77UHMK10.59469832
78FYN0.58902884
79PRKD10.58682546
80EEF2K0.58349860
81PRKCZ0.55577896
82PRKACG0.54254480
83FES0.53215855
84AKT30.53120563
85MAP3K90.52941469
86CSNK1E0.51129303
87MET0.51021676
88CDK60.50629430
89MARK10.50579611
90ERBB20.49664712
91EGFR0.46350285
92CSK0.45841728
93PRKCQ0.45076197
94PDK10.43818871
95RIPK10.43716281
96MAP3K130.42160320
97JAK10.41332858
98PDPK10.40069004
99GRK50.39508067
100DAPK30.37877132

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.69842540
2Tryptophan metabolism_Homo sapiens_hsa003803.79311962
3African trypanosomiasis_Homo sapiens_hsa051433.56685549
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.34601285
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02577289
6Sulfur metabolism_Homo sapiens_hsa009202.18890145
7Fatty acid degradation_Homo sapiens_hsa000712.18022065
8Fatty acid metabolism_Homo sapiens_hsa012122.14112761
9Arginine biosynthesis_Homo sapiens_hsa002202.08226710
10PPAR signaling pathway_Homo sapiens_hsa033201.80370092
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76488522
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69874701
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66793922
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54422149
15Salivary secretion_Homo sapiens_hsa049701.44693992
16Glycerolipid metabolism_Homo sapiens_hsa005611.43100762
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35900785
18Propanoate metabolism_Homo sapiens_hsa006401.28746032
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.26331881
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24998475
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23814416
22Complement and coagulation cascades_Homo sapiens_hsa046101.23644796
23Gastric acid secretion_Homo sapiens_hsa049711.14072987
24Renin secretion_Homo sapiens_hsa049241.13283560
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12248301
26Butanoate metabolism_Homo sapiens_hsa006501.10924961
27Bile secretion_Homo sapiens_hsa049761.10178920
28Lysosome_Homo sapiens_hsa041421.09815259
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09067346
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06924181
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05812957
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04992458
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04701295
34Pyruvate metabolism_Homo sapiens_hsa006201.03806075
35Fat digestion and absorption_Homo sapiens_hsa049750.99574225
36beta-Alanine metabolism_Homo sapiens_hsa004100.99302122
37GABAergic synapse_Homo sapiens_hsa047270.98860566
38Long-term potentiation_Homo sapiens_hsa047200.95966881
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95365680
40Phenylalanine metabolism_Homo sapiens_hsa003600.94755415
41Starch and sucrose metabolism_Homo sapiens_hsa005000.89740682
42Vibrio cholerae infection_Homo sapiens_hsa051100.86235418
43Estrogen signaling pathway_Homo sapiens_hsa049150.85832021
44Collecting duct acid secretion_Homo sapiens_hsa049660.85187288
45Circadian entrainment_Homo sapiens_hsa047130.78500017
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77467930
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76984255
48Prion diseases_Homo sapiens_hsa050200.76347181
49* Thyroid hormone synthesis_Homo sapiens_hsa049180.73572343
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73463528
51Arginine and proline metabolism_Homo sapiens_hsa003300.72542148
52Fatty acid biosynthesis_Homo sapiens_hsa000610.71553800
53Histidine metabolism_Homo sapiens_hsa003400.71528930
54Fatty acid elongation_Homo sapiens_hsa000620.71255366
55Carbon metabolism_Homo sapiens_hsa012000.68997972
56Staphylococcus aureus infection_Homo sapiens_hsa051500.67806456
57Synaptic vesicle cycle_Homo sapiens_hsa047210.67587411
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.66908631
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62206406
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61515721
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61207570
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61049795
63Biosynthesis of amino acids_Homo sapiens_hsa012300.60941552
64Amphetamine addiction_Homo sapiens_hsa050310.59014302
65Glutamatergic synapse_Homo sapiens_hsa047240.55566277
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52987600
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.52931820
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.52545801
69Peroxisome_Homo sapiens_hsa041460.51306604
70Folate biosynthesis_Homo sapiens_hsa007900.51182626
71Insulin secretion_Homo sapiens_hsa049110.49721420
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49492180
73* Glutathione metabolism_Homo sapiens_hsa004800.48635502
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48279774
75Tyrosine metabolism_Homo sapiens_hsa003500.46749287
76Vitamin B6 metabolism_Homo sapiens_hsa007500.45990074
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45703752
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.44148468
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43598677
80Chemical carcinogenesis_Homo sapiens_hsa052040.43469554
81GnRH signaling pathway_Homo sapiens_hsa049120.42502866
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42180459
83Glucagon signaling pathway_Homo sapiens_hsa049220.42004909
84Glioma_Homo sapiens_hsa052140.41317111
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40825401
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40805795
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39734267
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.39525252
89N-Glycan biosynthesis_Homo sapiens_hsa005100.39409768
90Dopaminergic synapse_Homo sapiens_hsa047280.39246173
91ABC transporters_Homo sapiens_hsa020100.38808229
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38180987
93Cholinergic synapse_Homo sapiens_hsa047250.36024491
94cAMP signaling pathway_Homo sapiens_hsa040240.33959516
95Melanogenesis_Homo sapiens_hsa049160.33563517
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33359388
97Insulin resistance_Homo sapiens_hsa049310.32733996
98Olfactory transduction_Homo sapiens_hsa047400.32251886
99Oxytocin signaling pathway_Homo sapiens_hsa049210.30315140
100Cocaine addiction_Homo sapiens_hsa050300.29837200

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