ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of chronic inflammatory response (GO:0002676)	9.09665966
2	single fertilization (GO:0007338)	8.60292132
3	indole-containing compound catabolic process (GO:0042436)	8.57867698
4	indolalkylamine catabolic process (GO:0046218)	8.57867698
5	tryptophan catabolic process (GO:0006569)	8.57867698
6	heterotypic cell-cell adhesion (GO:0034113)	8.54034023
7	positive regulation of type 2 immune response (GO:0002830)	7.45082099
8	tryptophan metabolic process (GO:0006568)	7.37489141
9	negative regulation of interleukin-10 production (GO:0032693)	7.36545838
10	aromatic amino acid family catabolic process (GO:0009074)	5.88510561
11	fertilization (GO:0009566)	5.67490275
12	amine catabolic process (GO:0009310)	5.52318649
13	cellular biogenic amine catabolic process (GO:0042402)	5.52318649
14	indolalkylamine metabolic process (GO:0006586)	5.41793661
15	negative regulation of interleukin-8 production (GO:0032717)	5.24932900
16	benzene-containing compound metabolic process (GO:0042537)	4.83101880
17	digestion (GO:0007586)	4.62921570
18	epithelial cell morphogenesis (GO:0003382)	4.37993970
19	negative regulation of T cell apoptotic process (GO:0070233)	4.37316455
20	negative regulation of endopeptidase activity (GO:0010951)	4.35105245
21	positive regulation of cell-cell adhesion (GO:0022409)	4.32025335
22	aromatic amino acid family metabolic process (GO:0009072)	4.25999863
23	negative regulation of peptidase activity (GO:0010466)	4.15343500
24	transepithelial transport (GO:0070633)	3.96823747
25	regulation of type 2 immune response (GO:0002828)	3.88535883
26	indole-containing compound metabolic process (GO:0042430)	3.87698190
27	regulation of clathrin-mediated endocytosis (GO:2000369)	3.78040420
28	reverse cholesterol transport (GO:0043691)	3.70076814
29	sulfur amino acid catabolic process (GO:0000098)	3.60188755
30	defense response to bacterium (GO:0042742)	3.53754504
31	N-acetylneuraminate metabolic process (GO:0006054)	3.41136928
32	negative regulation of protein autophosphorylation (GO:0031953)	3.34330332
33	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.31762475
34	phospholipid homeostasis (GO:0055091)	3.22892448
35	alpha-linolenic acid metabolic process (GO:0036109)	3.13407905
36	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.11227138
37	response to bacterium (GO:0009617)	3.05829780
38	regulation of macrophage activation (GO:0043030)	3.01322694
39	seminiferous tubule development (GO:0072520)	25.0875312
40	regulation of lipoprotein metabolic process (GO:0050746)	2.98785132
41	negative regulation of proteolysis (GO:0045861)	2.80924782
42	glial cell proliferation (GO:0014009)	2.80260632
43	cysteine metabolic process (GO:0006534)	2.76711354
44	regulation of beta-amyloid formation (GO:1902003)	2.73965910
45	sialylation (GO:0097503)	2.72698915
46	complement activation, alternative pathway (GO:0006957)	2.72107807
47	regulation of activated T cell proliferation (GO:0046006)	2.72005098
48	negative regulation of glycogen biosynthetic process (GO:0045719)	2.72004490
49	negative regulation of protein processing (GO:0010955)	2.70975262
50	negative regulation of protein maturation (GO:1903318)	2.70975262
51	O-glycan processing (GO:0016266)	2.69127505
52	high-density lipoprotein particle remodeling (GO:0034375)	2.67445208
53	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.67216364
54	positive regulation of cellular amide metabolic process (GO:0034250)	2.64018843
55	low-density lipoprotein particle clearance (GO:0034383)	2.57990685
56	positive regulation of interleukin-12 production (GO:0032735)	2.55306815
57	columnar/cuboidal epithelial cell development (GO:0002066)	2.52617413
58	hormone catabolic process (GO:0042447)	2.52163067
59	negative regulation of hydrolase activity (GO:0051346)	2.51984349
60	negative regulation of receptor-mediated endocytosis (GO:0048261)	2.48172614
61	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.47313654
62	negative regulation of glycogen metabolic process (GO:0070874)	2.46400829
63	L-serine transport (GO:0015825)	2.37006334
64	alpha-amino acid catabolic process (GO:1901606)	2.33743633
65	valine metabolic process (GO:0006573)	2.33420665
66	regulation of endopeptidase activity (GO:0052548)	2.32994037
67	lipid catabolic process (GO:0016042)	2.31486458
68	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.30345740
69	cellular amino acid catabolic process (GO:0009063)	2.26106048
70	negative regulation of interleukin-6 production (GO:0032715)	2.25215620
71	triglyceride catabolic process (GO:0019433)	2.24675130
72	response to misfolded protein (GO:0051788)	2.23661586
73	regulation of T cell apoptotic process (GO:0070232)	2.22307992
74	L-phenylalanine catabolic process (GO:0006559)	2.22246236
75	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.22246236
76	regulation of peptidase activity (GO:0052547)	2.21376585
77	acylglycerol catabolic process (GO:0046464)	2.18529586
78	neutral lipid catabolic process (GO:0046461)	2.18529586
79	protein-lipid complex remodeling (GO:0034368)	2.15931124
80	macromolecular complex remodeling (GO:0034367)	2.15931124
81	plasma lipoprotein particle remodeling (GO:0034369)	2.15931124
82	positive regulation of sterol transport (GO:0032373)	2.10888588
83	positive regulation of cholesterol transport (GO:0032376)	2.10888588
84	Golgi transport vesicle coating (GO:0048200)	2.10369367
85	COPI coating of Golgi vesicle (GO:0048205)	2.10369367
86	regulation of interleukin-10 production (GO:0032653)	2.09270429
87	cellular modified amino acid catabolic process (GO:0042219)	2.08064498
88	myelin maintenance (GO:0043217)	2.07579679
89	cellular response to epidermal growth factor stimulus (GO:0071364)	2.07260142
90	glutamate metabolic process (GO:0006536)	2.06998377
91	negative regulation of T cell proliferation (GO:0042130)	2.05295502
92	serine transport (GO:0032329)	2.04926382
93	activation of protein kinase A activity (GO:0034199)	2.03779174
94	regulation of reproductive process (GO:2000241)	2.00083701
95	regulation of T cell tolerance induction (GO:0002664)	14.3540839
96	production of molecular mediator involved in inflammatory response (GO:0002532)	14.3463474
97	positive regulation of tolerance induction (GO:0002645)	12.3123729
98	sperm capacitation (GO:0048240)	11.1635125
99	regulation of tolerance induction (GO:0002643)	10.7156735
100	kynurenine metabolic process (GO:0070189)	10.4825669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	4.74864766
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.19847524
3	IKZF1_21737484_ChIP-ChIP_HCT116_Human	4.02533766
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.21169130
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.15477988
6	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.63748077
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.59990859
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.58766548
9	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.54364141
10	ZNF263_19887448_ChIP-Seq_K562_Human	2.50798916
11	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.45519226
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.35697332
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.32144071
14	DNAJC2_21179169_ChIP-ChIP_NT2_Human	2.19234983
15	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.11085871
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.06205383
17	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	2.05571174
18	CLOCK_20551151_ChIP-Seq_293T_Human	1.99591531
19	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.88959187
20	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.84293346
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79785954
22	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.75234413
23	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.68138554
24	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.67660148
25	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.67553093
26	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.63908577
27	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.62802785
28	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.59024742
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57309713
30	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.55869247
31	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.53120534
32	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.52895519
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52044333
34	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52044333
35	STAT1_17558387_ChIP-Seq_HELA_Human	1.48252412
36	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.47988713
37	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.47073668
38	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.46482983
39	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.44397159
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39509305
41	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.38824423
42	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.38444862
43	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.34026903
44	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.31596225
45	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.31505702
46	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.29648558
47	P68_20966046_ChIP-Seq_HELA_Human	1.24054434
48	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23015074
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.18299581
50	RACK7_27058665_Chip-Seq_MCF-7_Human	1.16732701
51	VDR_24787735_ChIP-Seq_THP-1_Human	1.16523053
52	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.16480873
53	SMC4_20622854_ChIP-Seq_HELA_Human	1.15692730
54	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.15580585
55	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.13334310
56	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.11736273
57	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.10546613
58	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.10203608
59	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.08347758
60	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.06697646
61	MYC_19915707_ChIP-ChIP_AK7_Human	1.06326379
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05940548
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.05438384
64	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.04658584
65	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.03720864
66	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03174645
67	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02685739
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00136102
69	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.99869246
70	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99230574
71	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99103393
72	BCL6_27268052_Chip-Seq_Bcells_Human	0.98371113
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98359192
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97994190
75	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97198256
76	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.95321730
77	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.94990695
78	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94380677
79	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.93756567
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93657580
81	KDM2B_26808549_Chip-Seq_REH_Human	0.93542100
82	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.93328460
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92611330
84	KDM2B_26808549_Chip-Seq_K562_Human	0.91310990
85	LXR_22292898_ChIP-Seq_THP-1_Human	0.91028361
86	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89253065
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89088832
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.88573044
89	P300_27268052_Chip-Seq_Bcells_Human	0.86999964
90	GATA1_19941826_ChIP-Seq_K562_Human	0.86768635
91	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.86592048
92	BCOR_27268052_Chip-Seq_Bcells_Human	0.85513524
93	SOX2_20726797_ChIP-Seq_SW620_Human	0.84884436
94	RAC3_21632823_ChIP-Seq_H3396_Human	0.84469668
95	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.84098842
96	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.81958416
97	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.80648051
98	OCT4_20526341_ChIP-Seq_ESCs_Human	0.80245342
99	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77694106
100	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.77694106

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	5.72325437
2	MP0003195_calcinosis	5.17683526
3	MP0002254_reproductive_system_inflammat	4.95286395
4	MP0004043_abnormal_pH_regulation	4.69808874
5	MP0010234_abnormal_vibrissa_follicle	4.23175766
6	MP0002139_abnormal_hepatobiliary_system	4.20432971
7	MP0005410_abnormal_fertilization	3.30890894
8	MP0005058_abnormal_lysosome_morphology	3.17513206
9	MP0003329_amyloid_beta_deposits	3.05899385
10	MP0000003_abnormal_adipose_tissue	2.20224795
11	MP0005360_urolithiasis	2.18461216
12	MP0000604_amyloidosis	2.09335659
13	MP0010329_abnormal_lipoprotein_level	2.07283541
14	MP0002168_other_aberrant_phenotype	2.00408111
15	MP0005365_abnormal_bile_salt	1.85845427
16	MP0003300_gastrointestinal_ulcer	1.78528218
17	MP0003566_abnormal_cell_adhesion	1.77203663
18	MP0004885_abnormal_endolymph	1.67750223
19	MP0001501_abnormal_sleep_pattern	1.60524438
20	MP0005085_abnormal_gallbladder_physiolo	1.60073559
21	MP0004130_abnormal_muscle_cell	1.58001723
22	MP0001765_abnormal_ion_homeostasis	1.53476525
23	MP0004859_abnormal_synaptic_plasticity	1.53373992
24	MP0005375_adipose_tissue_phenotype	1.53362238
25	MP0002837_dystrophic_cardiac_calcinosis	1.53251558
26	MP0001440_abnormal_grooming_behavior	1.48122075
27	MP0001853_heart_inflammation	1.42919309
28	MP0003690_abnormal_glial_cell	1.39789019
29	MP0000534_abnormal_ureter_morphology	1.38162284
30	MP0004858_abnormal_nervous_system	1.35718114
31	MP0009643_abnormal_urine_homeostasis	1.35483491
32	MP0003705_abnormal_hypodermis_morpholog	1.33088537
33	MP0005332_abnormal_amino_acid	1.29543454
34	MP0004185_abnormal_adipocyte_glucose	1.29308500
35	MP0005083_abnormal_biliary_tract	1.27763903
36	MP0008438_abnormal_cutaneous_collagen	1.20484082
37	MP0002118_abnormal_lipid_homeostasis	1.19411226
38	MP0002089_abnormal_postnatal_growth/wei	1.17967912
39	MP0005584_abnormal_enzyme/coenzyme_acti	1.16352132
40	MP0001756_abnormal_urination	1.15186554
41	MP0000537_abnormal_urethra_morphology	1.14984982
42	MP0005275_abnormal_skin_tensile	1.11124793
43	MP0002896_abnormal_bone_mineralization	1.07446129
44	MP0003806_abnormal_nucleotide_metabolis	1.07073308
45	MP0003191_abnormal_cellular_cholesterol	1.06928559
46	MP0004270_analgesia	1.06272787
47	MP0003252_abnormal_bile_duct	1.06129428
48	MP0002796_impaired_skin_barrier	1.03991891
49	MP0009780_abnormal_chondrocyte_physiolo	1.01819529
50	MP0005636_abnormal_mineral_homeostasis	0.99476586
51	MP0003075_altered_response_to	0.97013743
52	MP0008875_abnormal_xenobiotic_pharmacok	0.96463906
53	MP0002909_abnormal_adrenal_gland	0.96172959
54	MP0003632_abnormal_nervous_system	0.95996406
55	MP0005666_abnormal_adipose_tissue	0.94592557
56	MP0000920_abnormal_myelination	0.93977565
57	MP0003879_abnormal_hair_cell	0.89078139
58	MP0002733_abnormal_thermal_nociception	0.85769269
59	MP0002136_abnormal_kidney_physiology	0.83663934
60	MP0000747_muscle_weakness	0.81427026
61	MP0002933_joint_inflammation	0.81185181
62	MP0004145_abnormal_muscle_electrophysio	0.80621241
63	MP0000609_abnormal_liver_physiology	0.78932079
64	MP0003635_abnormal_synaptic_transmissio	0.78667116
65	MP0003631_nervous_system_phenotype	0.77755633
66	MP0004036_abnormal_muscle_relaxation	0.77241435
67	MP0002876_abnormal_thyroid_physiology	0.76395791
68	MP0003633_abnormal_nervous_system	0.75724878
69	MP0005319_abnormal_enzyme/_coenzyme	0.72776009
70	MP0002735_abnormal_chemical_nociception	0.71985578
71	MP0005395_other_phenotype	0.69883651
72	MP0005670_abnormal_white_adipose	0.69485706
73	MP0009840_abnormal_foam_cell	0.68972049
74	MP0005535_abnormal_body_temperature	0.64843842
75	MP0010678_abnormal_skin_adnexa	0.64046857
76	MP0009384_cardiac_valve_regurgitation	0.64017714
77	MP0000538_abnormal_urinary_bladder	0.63990401
78	MP0002272_abnormal_nervous_system	0.63779403
79	MP0003634_abnormal_glial_cell	0.63715588
80	MP0005334_abnormal_fat_pad	0.63561035
81	MP0000462_abnormal_digestive_system	0.61994621
82	MP0005623_abnormal_meninges_morphology	0.61494075
83	MP0002295_abnormal_pulmonary_circulatio	0.61052092
84	MP0001970_abnormal_pain_threshold	0.60467431
85	MP0000249_abnormal_blood_vessel	0.60174591
86	MP0001666_abnormal_nutrient_absorption	0.59748881
87	MP0002971_abnormal_brown_adipose	0.59708632
88	MP0004272_abnormal_basement_membrane	0.57251656
89	MP0000751_myopathy	0.57185711
90	MP0009053_abnormal_anal_canal	0.56352921
91	MP0002064_seizures	0.55469725
92	MP0005166_decreased_susceptibility_to	0.54650712
93	MP0002653_abnormal_ependyma_morphology	0.53033620
94	MP0000013_abnormal_adipose_tissue	0.52761069
95	MP0003959_abnormal_lean_body	0.52286648
96	MP0002138_abnormal_hepatobiliary_system	0.51468059
97	MP0004087_abnormal_muscle_fiber	0.50474994
98	MP0001177_atelectasis	0.50286453
99	MP0005164_abnormal_response_to	0.48270717
100	MP0006138_congestive_heart_failure	0.47628528

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myocardial infarction (HP:0001658)	5.39158966
2	Hypophosphatemic rickets (HP:0004912)	5.08112744
3	Facial shape deformation (HP:0011334)	4.76611636
4	Potter facies (HP:0002009)	4.76611636
5	Vascular calcification (HP:0004934)	4.72565970
6	Complement deficiency (HP:0004431)	4.61226437
7	Cardiovascular calcification (HP:0011915)	4.40667871
8	Neurofibrillary tangles (HP:0002185)	4.32804634
9	Cerebral inclusion bodies (HP:0100314)	4.20135081
10	Malnutrition (HP:0004395)	3.95569734
11	Choroideremia (HP:0001139)	3.73223884
12	Neoplasm of the heart (HP:0100544)	3.56326591
13	Abnormality of complement system (HP:0005339)	3.35848763
14	Recurrent gram-negative bacterial infections (HP:0005420)	3.22557570
15	Infantile muscular hypotonia (HP:0008947)	3.21094728
16	Supranuclear gaze palsy (HP:0000605)	3.19991933
17	Widely patent fontanelles and sutures (HP:0004492)	3.19299610
18	Xanthomatosis (HP:0000991)	3.17758511
19	Intention tremor (HP:0002080)	3.15441432
20	Rickets (HP:0002748)	3.13823690
21	Deep venous thrombosis (HP:0002625)	3.11832717
22	Agitation (HP:0000713)	3.04244352
23	Choreoathetosis (HP:0001266)	3.02939547
24	Hemiplegia (HP:0002301)	2.75597891
25	Ketoacidosis (HP:0001993)	2.70552708
26	Ketosis (HP:0001946)	2.50340063
27	Abnormality of the fovea (HP:0000493)	2.47559921
28	Intrahepatic cholestasis (HP:0001406)	2.44805197
29	Difficulty running (HP:0009046)	2.43301760
30	Polar cataract (HP:0010696)	2.43233862
31	Hemorrhage of the eye (HP:0011885)	2.37535206
32	Gout (HP:0001997)	2.36903251
33	Vacuolated lymphocytes (HP:0001922)	2.35784327
34	Hypopigmentation of the fundus (HP:0007894)	2.35781572
35	Skin nodule (HP:0200036)	2.30786027
36	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.29285105
37	Hyporeflexia of lower limbs (HP:0002600)	2.26325444
38	Testicular atrophy (HP:0000029)	2.26094208
39	Acanthosis nigricans (HP:0000956)	2.24915835
40	Hyperglycinuria (HP:0003108)	2.24837633
41	Abnormality of purine metabolism (HP:0004352)	2.19452472
42	Peripheral hypomyelination (HP:0007182)	2.19251497
43	Abnormal hemoglobin (HP:0011902)	2.17997667
44	Epidermoid cyst (HP:0200040)	2.14600553
45	Gait ataxia (HP:0002066)	2.10477046
46	Osteomalacia (HP:0002749)	2.10255439
47	Hyperlipoproteinemia (HP:0010980)	2.09542931
48	Hepatoblastoma (HP:0002884)	2.03384174
49	Thin bony cortex (HP:0002753)	2.02884570
50	Focal segmental glomerulosclerosis (HP:0000097)	2.02137759
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.01623910
52	Spastic diplegia (HP:0001264)	1.99572755
53	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99514603
54	Abnormality of glycine metabolism (HP:0010895)	1.99514603
55	Myokymia (HP:0002411)	1.98466664
56	Ulnar claw (HP:0001178)	1.96358873
57	Right ventricular cardiomyopathy (HP:0011663)	1.96285841
58	Hyperparathyroidism (HP:0000843)	1.96019084
59	Segmental peripheral demyelination/remyelination (HP:0003481)	1.91643741
60	Muscle fiber splitting (HP:0003555)	1.89214473
61	Dysostosis multiplex (HP:0000943)	1.88259394
62	Increased connective tissue (HP:0009025)	1.88013419
63	Hypertriglyceridemia (HP:0002155)	1.86738563
64	Ectopia lentis (HP:0001083)	1.86585318
65	Systemic lupus erythematosus (HP:0002725)	1.86342449
66	Wide cranial sutures (HP:0010537)	1.85878866
67	Hyperammonemia (HP:0001987)	1.85574156
68	Hypoalphalipoproteinemia (HP:0003233)	1.85084171
69	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.81856159
70	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.81856159
71	Restlessness (HP:0000711)	1.81599985
72	Hyperphosphatemia (HP:0002905)	1.81353424
73	Prominent nose (HP:0000448)	1.80959194
74	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.79754615
75	Hypophosphatemia (HP:0002148)	1.78613321
76	Glomerulosclerosis (HP:0000096)	1.76831936
77	Gastrointestinal dysmotility (HP:0002579)	1.76311634
78	Psychosis (HP:0000709)	1.74332545
79	Increased CSF protein (HP:0002922)	1.72234523
80	Turricephaly (HP:0000262)	1.71434879
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.71229878
82	Oligomenorrhea (HP:0000876)	1.70450401
83	Progressive neurologic deterioration (HP:0002344)	1.69335610
84	Amyloidosis (HP:0011034)	1.67384078
85	Pili torti (HP:0003777)	1.66696809
86	Tubulointerstitial fibrosis (HP:0005576)	1.66577288
87	Abnormality of the periventricular white matter (HP:0002518)	1.65005901
88	Abnormal cartilage morphology (HP:0002763)	1.63336512
89	Abnormality of the Achilles tendon (HP:0005109)	1.62329039
90	Calf muscle hypertrophy (HP:0008981)	1.62107411
91	Hyperglycinemia (HP:0002154)	1.60832828
92	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.60409186
93	Back pain (HP:0003418)	1.60073833
94	Abnormality of transition element cation homeostasis (HP:0011030)	1.58600131
95	Abdominal situs inversus (HP:0003363)	1.58203492
96	Abnormality of abdominal situs (HP:0011620)	1.58203492
97	Subcapsular cataract (HP:0000523)	1.57964115
98	Prominent forehead (HP:0011220)	1.57588112
99	Abnormality of the corticospinal tract (HP:0002492)	1.56452016
100	Loss of speech (HP:0002371)	1.56410244

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.67720564
2	ERN1	3.28298596
3	LMTK2	3.18224352
4	EPHB1	2.83621463
5	SIK1	2.66334261
6	PKN2	2.54605839
7	LRRK2	2.33129186
8	PDGFRA	2.18429370
9	TRIB3	2.16490712
10	FGFR2	2.15370108
11	FER	2.14070747
12	FGFR4	1.93672206
13	TAOK3	1.87328074
14	STK39	1.84303841
15	WNK4	1.82418201
16	PRKD3	1.82091366
17	MAP3K2	1.57041699
18	PTK6	1.49587217
19	EPHA2	1.44176449
20	TNK2	1.42737003
21	NTRK3	1.38558317
22	TTN	1.38332635
23	RET	1.36655387
24	TYRO3	1.30816732
25	PTK2B	1.29246668
26	NTRK1	1.27315040
27	PAK3	1.25171188
28	RIPK4	1.23451463
29	PTK2	1.19008846
30	MAP2K4	1.16705615
31	MYLK	1.14551326
32	INSR	1.12148717
33	PRKCH	1.10184761
34	SCYL2	1.09479233
35	PAK6	1.09024448
36	KSR2	1.08998144
37	CDK19	1.08441107
38	STK10	1.07410307
39	TESK1	1.07063380
40	FRK	1.01077502
41	BCKDK	1.00747459
42	FGFR3	0.96915221
43	DMPK	0.90525031
44	MAP3K7	0.90481845
45	LATS2	0.89957718
46	EPHB2	0.84308132
47	PAK4	0.83127550
48	CDK5	0.82634011
49	ICK	0.82621905
50	ALK	0.81328724
51	PAK2	0.81040070
52	SIK2	0.80688204
53	EPHA4	0.80106368
54	MAP3K6	0.77609351
55	MAP3K12	0.77439718
56	PDK4	0.73866810
57	PDK3	0.73866810
58	MAP2K1	0.72899001
59	WNK1	0.72521670
60	NTRK2	0.71748134
61	PHKG2	0.70162691
62	PHKG1	0.70162691
63	MINK1	0.69969937
64	CAMK1G	0.69247484
65	PRKCG	0.69017763
66	DDR2	0.67578697
67	DAPK2	0.66258874
68	GSK3A	0.65932207
69	JAK2	0.65222571
70	FLT3	0.64039564
71	STK38	0.63994514
72	FGFR1	0.62744079
73	ROCK2	0.62629293
74	LATS1	0.61550417
75	SRC	0.60872319
76	PDGFRB	0.59582495
77	UHMK1	0.59469832
78	FYN	0.58902884
79	PRKD1	0.58682546
80	EEF2K	0.58349860
81	PRKCZ	0.55577896
82	PRKACG	0.54254480
83	FES	0.53215855
84	AKT3	0.53120563
85	MAP3K9	0.52941469
86	CSNK1E	0.51129303
87	MET	0.51021676
88	CDK6	0.50629430
89	MARK1	0.50579611
90	ERBB2	0.49664712
91	EGFR	0.46350285
92	CSK	0.45841728
93	PRKCQ	0.45076197
94	PDK1	0.43818871
95	RIPK1	0.43716281
96	MAP3K13	0.42160320
97	JAK1	0.41332858
98	PDPK1	0.40069004
99	GRK5	0.39508067
100	DAPK3	0.37877132

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	5.69842540
2	Tryptophan metabolism_Homo sapiens_hsa00380	3.79311962
3	African trypanosomiasis_Homo sapiens_hsa05143	3.56685549
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.34601285
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.02577289
6	Sulfur metabolism_Homo sapiens_hsa00920	2.18890145
7	Fatty acid degradation_Homo sapiens_hsa00071	2.18022065
8	Fatty acid metabolism_Homo sapiens_hsa01212	2.14112761
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.08226710
10	PPAR signaling pathway_Homo sapiens_hsa03320	1.80370092
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76488522
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69874701
13	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.66793922
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54422149
15	Salivary secretion_Homo sapiens_hsa04970	1.44693992
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.43100762
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35900785
18	Propanoate metabolism_Homo sapiens_hsa00640	1.28746032
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26331881
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24998475
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.23814416
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.23644796
23	Gastric acid secretion_Homo sapiens_hsa04971	1.14072987
24	Renin secretion_Homo sapiens_hsa04924	1.13283560
25	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.12248301
26	Butanoate metabolism_Homo sapiens_hsa00650	1.10924961
27	Bile secretion_Homo sapiens_hsa04976	1.10178920
28	Lysosome_Homo sapiens_hsa04142	1.09815259
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09067346
30	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.06924181
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05812957
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04992458
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04701295
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.03806075
35	Fat digestion and absorption_Homo sapiens_hsa04975	0.99574225
36	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99302122
37	GABAergic synapse_Homo sapiens_hsa04727	0.98860566
38	Long-term potentiation_Homo sapiens_hsa04720	0.95966881
39	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.95365680
40	Phenylalanine metabolism_Homo sapiens_hsa00360	0.94755415
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.89740682
42	Vibrio cholerae infection_Homo sapiens_hsa05110	0.86235418
43	Estrogen signaling pathway_Homo sapiens_hsa04915	0.85832021
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85187288
45	Circadian entrainment_Homo sapiens_hsa04713	0.78500017
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77467930
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76984255
48	Prion diseases_Homo sapiens_hsa05020	0.76347181
49	* Thyroid hormone synthesis_Homo sapiens_hsa04918	0.73572343
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.73463528
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72542148
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71553800
53	Histidine metabolism_Homo sapiens_hsa00340	0.71528930
54	Fatty acid elongation_Homo sapiens_hsa00062	0.71255366
55	Carbon metabolism_Homo sapiens_hsa01200	0.68997972
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.67806456
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.67587411
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66908631
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62206406
60	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61515721
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61207570
62	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.61049795
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.60941552
64	Amphetamine addiction_Homo sapiens_hsa05031	0.59014302
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.55566277
66	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.52987600
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52931820
68	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.52545801
69	Peroxisome_Homo sapiens_hsa04146	0.51306604
70	Folate biosynthesis_Homo sapiens_hsa00790	0.51182626
71	Insulin secretion_Homo sapiens_hsa04911	0.49721420
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49492180
73	* Glutathione metabolism_Homo sapiens_hsa00480	0.48635502
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48279774
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.46749287
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.45990074
77	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45703752
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.44148468
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43598677
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43469554
81	GnRH signaling pathway_Homo sapiens_hsa04912	0.42502866
82	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42180459
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42004909
84	Glioma_Homo sapiens_hsa05214	0.41317111
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40825401
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40805795
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39734267
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39525252
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.39409768
90	Dopaminergic synapse_Homo sapiens_hsa04728	0.39246173
91	ABC transporters_Homo sapiens_hsa02010	0.38808229
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.38180987
93	Cholinergic synapse_Homo sapiens_hsa04725	0.36024491
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.33959516
95	Melanogenesis_Homo sapiens_hsa04916	0.33563517
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33359388
97	Insulin resistance_Homo sapiens_hsa04931	0.32733996
98	Olfactory transduction_Homo sapiens_hsa04740	0.32251886
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30315140
100	Cocaine addiction_Homo sapiens_hsa05030	0.29837200

GPX5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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