GRAMD1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)7.47688487
2glucocorticoid metabolic process (GO:0008211)6.65971425
3cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.82456381
4androgen biosynthetic process (GO:0006702)5.59442468
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52971332
6synaptic vesicle maturation (GO:0016188)5.48049477
7locomotory exploration behavior (GO:0035641)5.44653367
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10727432
9sodium ion export (GO:0071436)5.00431670
10cellular potassium ion homeostasis (GO:0030007)4.98943137
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.98104509
12response to insecticide (GO:0017085)4.82211061
13C21-steroid hormone biosynthetic process (GO:0006700)4.73286254
14estrogen biosynthetic process (GO:0006703)4.68603287
15response to follicle-stimulating hormone (GO:0032354)4.55525953
16neuronal ion channel clustering (GO:0045161)4.48879268
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.47933176
18cellular response to antibiotic (GO:0071236)4.47279754
19synaptic vesicle exocytosis (GO:0016079)4.43318284
20glutamate secretion (GO:0014047)4.40767726
21cellular response to epinephrine stimulus (GO:0071872)4.30790608
22cellular response to gonadotropin stimulus (GO:0071371)4.30322311
23vocalization behavior (GO:0071625)4.29245806
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.25522968
25regulation of synaptic vesicle exocytosis (GO:2000300)4.24759091
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.09165839
27central nervous system myelination (GO:0022010)3.95682332
28axon ensheathment in central nervous system (GO:0032291)3.95682332
29progesterone metabolic process (GO:0042448)3.93428669
30neurotransmitter secretion (GO:0007269)3.92609416
31regulation of glutamate receptor signaling pathway (GO:1900449)3.91139548
32cellular response to toxic substance (GO:0097237)3.90836485
33cerebellar Purkinje cell differentiation (GO:0021702)3.89150420
34neuronal action potential propagation (GO:0019227)3.85283215
35regulation of synaptic vesicle transport (GO:1902803)3.77594932
36protein localization to synapse (GO:0035418)3.76826118
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.76779630
38exploration behavior (GO:0035640)3.71958895
39gamma-aminobutyric acid transport (GO:0015812)3.71026332
40glutamate receptor signaling pathway (GO:0007215)3.70464493
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69620788
42synaptic transmission, glutamatergic (GO:0035249)3.66919015
43proline transport (GO:0015824)3.64774992
44regulation of clathrin-mediated endocytosis (GO:2000369)3.62968652
45long-term memory (GO:0007616)3.58519871
46regulation of ARF protein signal transduction (GO:0032012)3.58016850
47regulation of neuronal synaptic plasticity (GO:0048168)3.56607555
48potassium ion import (GO:0010107)3.55758453
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53119198
50cellular response to catecholamine stimulus (GO:0071870)3.50642963
51cellular response to monoamine stimulus (GO:0071868)3.50642963
52response to epinephrine (GO:0071871)3.49342383
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44575351
54L-amino acid import (GO:0043092)3.44400261
55layer formation in cerebral cortex (GO:0021819)3.43836605
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42796724
57positive regulation of nitric-oxide synthase activity (GO:0051000)3.42671036
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.39614782
59neuron-neuron synaptic transmission (GO:0007270)3.38073488
60cytoskeletal anchoring at plasma membrane (GO:0007016)3.37530088
61retinal cone cell development (GO:0046549)3.34588038
62cell communication by electrical coupling (GO:0010644)3.33057942
63potassium ion homeostasis (GO:0055075)3.32803682
64neurotransmitter transport (GO:0006836)3.31388936
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30719464
66regulation of synapse maturation (GO:0090128)3.28866809
67regulation of postsynaptic membrane potential (GO:0060078)3.28515132
68positive regulation of membrane potential (GO:0045838)3.27539402
69cellular sodium ion homeostasis (GO:0006883)3.27017061
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23066326
71regulation of synapse structural plasticity (GO:0051823)3.21464145
72regulation of voltage-gated calcium channel activity (GO:1901385)3.20700473
73response to corticosterone (GO:0051412)3.19214851
74positive regulation of dendritic spine development (GO:0060999)3.18153821
75membrane hyperpolarization (GO:0060081)3.17838824
76synaptic vesicle endocytosis (GO:0048488)3.16509500
77regulation of rhodopsin mediated signaling pathway (GO:0022400)3.16269534
78activation of protein kinase A activity (GO:0034199)3.16168724
79postsynaptic membrane organization (GO:0001941)3.14980666
80C21-steroid hormone metabolic process (GO:0008207)3.14195468
81rhodopsin mediated signaling pathway (GO:0016056)3.13585579
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.13104772
83neuromuscular process controlling balance (GO:0050885)3.12228831
84glycine transport (GO:0015816)3.10765208
85neurotransmitter-gated ion channel clustering (GO:0072578)3.10356227
86membrane depolarization during action potential (GO:0086010)3.07628663
87regulation of neurotransmitter secretion (GO:0046928)3.02784553
88response to catecholamine (GO:0071869)3.00885169
89response to monoamine (GO:0071867)3.00885169
90cerebellar granule cell differentiation (GO:0021707)2.99728673
91mating behavior (GO:0007617)2.98050302
92positive regulation of triglyceride biosynthetic process (GO:0010867)2.96924797
93response to gonadotropin (GO:0034698)2.95338148
94negative regulation of dendrite morphogenesis (GO:0050774)2.95047272
95response to histamine (GO:0034776)2.94244352
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94044918
97regulation of synaptic plasticity (GO:0048167)2.93418897
98chemosensory behavior (GO:0007635)2.90680511
99dendrite morphogenesis (GO:0048813)2.89830969
100regulation of neurotransmitter levels (GO:0001505)2.88439463
101positive regulation of synapse maturation (GO:0090129)2.88308253
102neuromuscular process controlling posture (GO:0050884)2.88241347
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87506364
104long-term synaptic potentiation (GO:0060291)2.87339275
105Leydig cell differentiation (GO:0033327)2.85909275
106membrane depolarization (GO:0051899)2.85145832
107membrane repolarization (GO:0086009)2.85025191
108response to mineralocorticoid (GO:0051385)2.84347039
109regulation of vesicle fusion (GO:0031338)2.83225664
110vesicle transport along microtubule (GO:0047496)2.82174296
111prepulse inhibition (GO:0060134)2.80539814
112innervation (GO:0060384)2.78939152
113positive regulation of neurotransmitter transport (GO:0051590)2.77699433
114neuron cell-cell adhesion (GO:0007158)2.76326023
115amino acid import (GO:0043090)2.73647055
116dendritic spine morphogenesis (GO:0060997)2.73416794
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.72475235
118regulation of neurotransmitter transport (GO:0051588)2.70837812
119establishment of nucleus localization (GO:0040023)2.69666504
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.69320542
121positive regulation of guanylate cyclase activity (GO:0031284)2.68962196
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.68726736
123response to auditory stimulus (GO:0010996)2.67792159
124cell differentiation in hindbrain (GO:0021533)2.63107101
125negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62663986
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.60843938
127negative regulation of cell killing (GO:0031342)2.60843938
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57490777
129neuromuscular process (GO:0050905)2.57378105
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57188238
131positive regulation of neurotransmitter secretion (GO:0001956)2.56989839
132transmission of nerve impulse (GO:0019226)2.56852498
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55787772
134regulation of dendritic spine morphogenesis (GO:0061001)2.55131059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46145318
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95352164
3DROSHA_22980978_ChIP-Seq_HELA_Human2.79902428
4GBX2_23144817_ChIP-Seq_PC3_Human2.77594923
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50074010
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.46795931
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44436016
8REST_21632747_ChIP-Seq_MESCs_Mouse2.35189597
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28854895
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24776524
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22673378
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20456008
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17574319
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17574319
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17401330
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01575687
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98416687
18* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92938185
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91474657
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88282014
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87602891
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.84050963
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.80861925
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80580241
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.77476318
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61404486
27AR_21572438_ChIP-Seq_LNCaP_Human1.59248344
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.57136958
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52899345
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47603778
31SMAD4_21799915_ChIP-Seq_A2780_Human1.47406928
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46623507
33KDM2B_26808549_Chip-Seq_K562_Human1.42572292
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.42500547
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.36595790
36GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36286088
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35718615
38* LXR_22292898_ChIP-Seq_THP-1_Human1.35674662
39AR_19668381_ChIP-Seq_PC3_Human1.27259229
40* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27148517
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.26576524
42* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25645581
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23360163
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23159453
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20929851
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20071718
47STAT3_23295773_ChIP-Seq_U87_Human1.19234623
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18028227
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17558289
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17411690
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16733945
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.15186026
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15149401
54AHR_22903824_ChIP-Seq_MCF-7_Human1.14284059
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14195619
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.14076036
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12719026
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.12291894
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.10948217
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10754488
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10227824
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08523524
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07341396
64TP53_16413492_ChIP-PET_HCT116_Human1.06992264
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06888350
66* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06236243
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05713738
68CTCF_27219007_Chip-Seq_Bcells_Human1.05210401
69SMC4_20622854_ChIP-Seq_HELA_Human1.03845130
70* AR_25329375_ChIP-Seq_VCAP_Human1.03233207
71TCF4_23295773_ChIP-Seq_U87_Human1.02900500
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01275411
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.01197035
74* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00650159
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00550164
76RXR_22108803_ChIP-Seq_LS180_Human1.00451516
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00243931
78P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99940694
79ZNF274_21170338_ChIP-Seq_K562_Hela0.99876313
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98139398
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97311826
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.97269163
83CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96645489
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.96552421
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.96236182
86CREB1_26743006_Chip-Seq_LNCaP_Human0.94864677
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94687087
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94630418
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.93694174
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93618901
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93281912
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92966491
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.92962715
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92559151
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.92148951
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91737871
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.91382619
98* KDM2B_26808549_Chip-Seq_DND41_Human0.91293792
99RUNX_20019798_ChIP-Seq_JUKART_Human0.90968320
100OCT4_19829295_ChIP-Seq_ESCs_Human0.90462151
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90366021
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89523532
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88809451
104GATA1_26923725_Chip-Seq_HPCs_Mouse0.88543584
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88117100
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87850771
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87534985
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87357979
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87357979
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86848311
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86537253
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86291141
113P300_19829295_ChIP-Seq_ESCs_Human0.85803123
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.85771110
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.85445336
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.84063581
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83824649
118* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83485667
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83253749
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82535042
121* TET1_21490601_ChIP-Seq_MESCs_Mouse0.81383078
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80798926
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80432629
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79100536
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78855649
126RNF2_27304074_Chip-Seq_NSC_Mouse0.78016357
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77285184
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77280319
129EGR1_19032775_ChIP-ChIP_M12_Human0.77092511
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76899137
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76648051
132KLF4_19829295_ChIP-Seq_ESCs_Human0.75756583
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74960130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.33603658
2MP0003635_abnormal_synaptic_transmissio3.78432099
3MP0009046_muscle_twitch3.44480495
4MP0004270_analgesia3.34049470
5MP0003880_abnormal_central_pattern3.22768583
6MP0005551_abnormal_eye_electrophysiolog3.01347077
7MP0009745_abnormal_behavioral_response3.00595552
8MP0002064_seizures2.97481127
9MP0005423_abnormal_somatic_nervous2.93521151
10MP0002063_abnormal_learning/memory/cond2.91255177
11MP0001968_abnormal_touch/_nociception2.53088316
12MP0002822_catalepsy2.52246719
13MP0008569_lethality_at_weaning2.48134123
14MP0002272_abnormal_nervous_system2.47350999
15MP0002572_abnormal_emotion/affect_behav2.44150510
16MP0000639_abnormal_adrenal_gland2.40608869
17MP0001486_abnormal_startle_reflex2.40352643
18MP0000569_abnormal_digit_pigmentation2.36981191
19MP0002734_abnormal_mechanical_nocicepti2.25359873
20MP0001501_abnormal_sleep_pattern2.25336833
21MP0002735_abnormal_chemical_nociception2.01356044
22MP0008004_abnormal_stomach_pH1.97667561
23MP0002067_abnormal_sensory_capabilities1.95412564
24MP0001440_abnormal_grooming_behavior1.90906298
25MP0003122_maternal_imprinting1.90088878
26MP0002909_abnormal_adrenal_gland1.85003290
27MP0003329_amyloid_beta_deposits1.83063320
28MP0004858_abnormal_nervous_system1.81893081
29MP0009780_abnormal_chondrocyte_physiolo1.77085915
30MP0005253_abnormal_eye_physiology1.76734385
31MP0002736_abnormal_nociception_after1.76650610
32MP0008961_abnormal_basal_metabolism1.76370558
33MP0004885_abnormal_endolymph1.75163821
34MP0001348_abnormal_lacrimal_gland1.68326979
35MP0001970_abnormal_pain_threshold1.63916247
36MP0002733_abnormal_thermal_nociception1.63281657
37MP0002229_neurodegeneration1.60720858
38MP0004043_abnormal_pH_regulation1.59763189
39MP0004510_myositis1.57160990
40MP0006072_abnormal_retinal_apoptosis1.56719975
41MP0003633_abnormal_nervous_system1.56574661
42MP0004811_abnormal_neuron_physiology1.54325137
43MP0003172_abnormal_lysosome_physiology1.53123402
44MP0003123_paternal_imprinting1.53115061
45MP0003879_abnormal_hair_cell1.52659135
46MP0004924_abnormal_behavior1.52532257
47MP0005386_behavior/neurological_phenoty1.52532257
48MP0001502_abnormal_circadian_rhythm1.51939195
49MP0002882_abnormal_neuron_morphology1.44576033
50MP0002184_abnormal_innervation1.44411850
51MP0003011_delayed_dark_adaptation1.40899164
52MP0002557_abnormal_social/conspecific_i1.39757418
53MP0000604_amyloidosis1.39140192
54MP0002090_abnormal_vision1.38824250
55MP0006276_abnormal_autonomic_nervous1.31881766
56MP0003045_fibrosis1.31535143
57MP0002066_abnormal_motor_capabilities/c1.28914160
58MP0003631_nervous_system_phenotype1.25460842
59MP0000778_abnormal_nervous_system1.23435627
60MP0004742_abnormal_vestibular_system1.23188938
61MP0003690_abnormal_glial_cell1.18321502
62MP0000955_abnormal_spinal_cord1.18187138
63MP0001984_abnormal_olfaction1.18068516
64MP0003787_abnormal_imprinting1.13326463
65MP0001765_abnormal_ion_homeostasis1.10836038
66MP0003634_abnormal_glial_cell1.05794493
67MP0003075_altered_response_to1.04988291
68MP0000920_abnormal_myelination1.00130559
69MP0005409_darkened_coat_color1.00088840
70MP0009840_abnormal_foam_cell0.99758180
71MP0005410_abnormal_fertilization0.99652678
72MP0004145_abnormal_muscle_electrophysio0.97170238
73MP0003300_gastrointestinal_ulcer0.96261986
74MP0005535_abnormal_body_temperature0.95086176
75MP0005646_abnormal_pituitary_gland0.94217910
76MP0010368_abnormal_lymphatic_system0.92750829
77MP0003632_abnormal_nervous_system0.92583021
78MP0005195_abnormal_posterior_eye0.91949153
79MP0004233_abnormal_muscle_weight0.91369970
80MP0004142_abnormal_muscle_tone0.91051946
81MP0002152_abnormal_brain_morphology0.90606929
82MP0000751_myopathy0.89906596
83MP0002638_abnormal_pupillary_reflex0.88847386
84MP0008872_abnormal_physiological_respon0.87786139
85MP0002752_abnormal_somatic_nervous0.85001761
86MP0002069_abnormal_eating/drinking_beha0.82189057
87MP0003183_abnormal_peptide_metabolism0.80022181
88MP0005623_abnormal_meninges_morphology0.79681661
89MP0003303_peritoneal_inflammation0.79497108
90MP0008874_decreased_physiological_sensi0.79055523
91MP0001905_abnormal_dopamine_level0.76415914
92MP0001963_abnormal_hearing_physiology0.75258813
93MP0003121_genomic_imprinting0.69604977
94MP0001177_atelectasis0.68299974
95MP0005310_abnormal_salivary_gland0.68172074
96MP0005167_abnormal_blood-brain_barrier0.67891847
97MP0000013_abnormal_adipose_tissue0.66264425
98MP0004130_abnormal_muscle_cell0.65551697
99MP0002089_abnormal_postnatal_growth/wei0.64728305
100MP0008875_abnormal_xenobiotic_pharmacok0.64619462
101MP0004484_altered_response_of0.64572329
102MP0000631_abnormal_neuroendocrine_gland0.63687348
103MP0004085_abnormal_heartbeat0.63622314
104MP0003283_abnormal_digestive_organ0.63202370
105MP0001324_abnormal_eye_pigmentation0.62726560
106MP0002876_abnormal_thyroid_physiology0.62134766
107MP0005645_abnormal_hypothalamus_physiol0.62040976
108MP0004215_abnormal_myocardial_fiber0.61403628
109MP0001188_hyperpigmentation0.57932752
110MP0010768_mortality/aging0.57098679
111MP0001346_abnormal_lacrimal_gland0.56772216
112MP0003953_abnormal_hormone_level0.56755148
113MP0003866_abnormal_defecation0.55830933
114MP0001849_ear_inflammation0.54862348
115MP0001299_abnormal_eye_distance/0.53114134
116MP0001485_abnormal_pinna_reflex0.52624845
117MP0010770_preweaning_lethality0.52033550
118MP0002082_postnatal_lethality0.52033550
119MP0005187_abnormal_penis_morphology0.51439960
120MP0003646_muscle_fatigue0.51173623
121MP0005166_decreased_susceptibility_to0.50897737
122MP0003137_abnormal_impulse_conducting0.50653059
123MP0001661_extended_life_span0.50248531
124MP0002254_reproductive_system_inflammat0.50126720
125MP0010769_abnormal_survival0.49964493
126MP0002332_abnormal_exercise_endurance0.49828626

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.69153126
2Myokymia (HP:0002411)5.20611062
3Congenital stationary night blindness (HP:0007642)4.82491735
4Renal salt wasting (HP:0000127)4.76267133
5Focal seizures (HP:0007359)4.69263665
6Action tremor (HP:0002345)4.59869796
7Visual hallucinations (HP:0002367)4.45522113
8Progressive cerebellar ataxia (HP:0002073)4.39589471
9Central scotoma (HP:0000603)3.99323297
10Dyschromatopsia (HP:0007641)3.85705254
11Febrile seizures (HP:0002373)3.81071640
12Gaze-evoked nystagmus (HP:0000640)3.77216060
13Bony spicule pigmentary retinopathy (HP:0007737)3.76164453
14Epileptic encephalopathy (HP:0200134)3.74064492
15Abnormality of macular pigmentation (HP:0008002)3.55411902
16Dysdiadochokinesis (HP:0002075)3.38079848
17Dysmetric saccades (HP:0000641)3.36454770
18Relative macrocephaly (HP:0004482)3.33139986
19Anomalous pulmonary venous return (HP:0010772)3.25701921
20Scotoma (HP:0000575)3.23793429
21Truncal ataxia (HP:0002078)3.21733478
22Atonic seizures (HP:0010819)3.20994550
23Genetic anticipation (HP:0003743)3.19653759
24Absence seizures (HP:0002121)3.15175336
25Supranuclear gaze palsy (HP:0000605)3.13698829
26Broad-based gait (HP:0002136)3.12252171
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11423070
28Impaired smooth pursuit (HP:0007772)3.07858969
29Abnormal rod and cone electroretinograms (HP:0008323)3.05276350
30Hemiplegia (HP:0002301)2.99350562
31Obstructive sleep apnea (HP:0002870)2.99123566
32Dysmetria (HP:0001310)2.96298909
33Abnormality of ocular smooth pursuit (HP:0000617)2.94699260
34Increased circulating renin level (HP:0000848)2.91386037
35Abnormality of the lower motor neuron (HP:0002366)2.90762445
36Abnormality of binocular vision (HP:0011514)2.90721568
37Diplopia (HP:0000651)2.90721568
38Dialeptic seizures (HP:0011146)2.82328812
39Urinary bladder sphincter dysfunction (HP:0002839)2.80983151
40Intention tremor (HP:0002080)2.80964395
41Impaired vibration sensation in the lower limbs (HP:0002166)2.79823471
42Abnormality of the pulmonary veins (HP:0011718)2.79109993
43Large earlobe (HP:0009748)2.77543131
44Generalized tonic-clonic seizures (HP:0002069)2.76535997
45Scanning speech (HP:0002168)2.74928545
46Abnormal social behavior (HP:0012433)2.73765967
47Impaired social interactions (HP:0000735)2.73765967
48Postural instability (HP:0002172)2.72283280
49Depression (HP:0000716)2.69883265
50Pigmentary retinal degeneration (HP:0001146)2.69637036
51Poor eye contact (HP:0000817)2.68643721
52Abnormal sex determination (HP:0012244)2.62751412
53Sex reversal (HP:0012245)2.62751412
54Cerebral hypomyelination (HP:0006808)2.61785504
55Urinary urgency (HP:0000012)2.56711400
56Abnormal eating behavior (HP:0100738)2.53174818
57Tetraplegia (HP:0002445)2.51138029
58Choroideremia (HP:0001139)2.50553787
59Ankle clonus (HP:0011448)2.49495870
60Enlarged penis (HP:0000040)2.45189965
61Limb dystonia (HP:0002451)2.43279753
62Torticollis (HP:0000473)2.39377154
63Decreased central vision (HP:0007663)2.38734694
64Hemiparesis (HP:0001269)2.34910687
65Abolished electroretinogram (ERG) (HP:0000550)2.32168590
66Macroorchidism (HP:0000053)2.31326736
67Bronchomalacia (HP:0002780)2.29969199
68Mutism (HP:0002300)2.29106362
69Metabolic alkalosis (HP:0200114)2.29060108
70Clonus (HP:0002169)2.28168296
71Aplasia involving bones of the upper limbs (HP:0009823)2.24640693
72Aplasia of the phalanges of the hand (HP:0009802)2.24640693
73Aplasia involving bones of the extremities (HP:0009825)2.24640693
74Macular degeneration (HP:0000608)2.23421142
75Spastic gait (HP:0002064)2.22788651
76Partial agenesis of the corpus callosum (HP:0001338)2.22337558
77Epileptiform EEG discharges (HP:0011182)2.22151432
78Adrenal overactivity (HP:0002717)2.21785108
79Hyperventilation (HP:0002883)2.20818148
80Stereotypic behavior (HP:0000733)2.16852375
81Abnormality of saccadic eye movements (HP:0000570)2.16543898
82Anxiety (HP:0000739)2.13495461
83Photophobia (HP:0000613)2.12095655
84Attenuation of retinal blood vessels (HP:0007843)2.09733848
85Neuronal loss in central nervous system (HP:0002529)2.08774114
86Excessive salivation (HP:0003781)2.08740659
87Drooling (HP:0002307)2.08740659
88Spinal canal stenosis (HP:0003416)2.08252867
89Status epilepticus (HP:0002133)2.07008586
90Impaired vibratory sensation (HP:0002495)2.05578704
91Chorioretinal atrophy (HP:0000533)2.04968804
92Insomnia (HP:0100785)2.04639705
93Accelerated skeletal maturation (HP:0005616)2.04327027
94Type II diabetes mellitus (HP:0005978)2.03203319
95Termporal pattern (HP:0011008)2.01949204
96Insidious onset (HP:0003587)2.01949204
97Ventricular fibrillation (HP:0001663)2.01858430
98Akinesia (HP:0002304)2.01768365
99Lower limb amyotrophy (HP:0007210)2.00714351
100Annular pancreas (HP:0001734)1.97941614
101Growth hormone excess (HP:0000845)1.97933430
102Bradykinesia (HP:0002067)1.97912079
103Thickened helices (HP:0000391)1.97399808
104Bundle branch block (HP:0011710)1.94365675
105EEG with generalized epileptiform discharges (HP:0011198)1.92716401
106Progressive inability to walk (HP:0002505)1.92207954
107Horizontal nystagmus (HP:0000666)1.92113406
108Pointed chin (HP:0000307)1.92051598
109Peripheral hypomyelination (HP:0007182)1.91731319
110Oligodactyly (hands) (HP:0001180)1.91488063
111Inappropriate behavior (HP:0000719)1.90703135
112Progressive visual loss (HP:0000529)1.89993697
113Postural tremor (HP:0002174)1.89009245
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88566742
115Abnormality of the corticospinal tract (HP:0002492)1.88027611
116Sleep apnea (HP:0010535)1.87355935
117Papilledema (HP:0001085)1.86812076
118Focal dystonia (HP:0004373)1.86363372
119Gait ataxia (HP:0002066)1.85770029
120Precocious puberty (HP:0000826)1.85656950
121Pendular nystagmus (HP:0012043)1.85267600
122Posterior subcapsular cataract (HP:0007787)1.83255208
123Spastic tetraparesis (HP:0001285)1.83001860
124Rigidity (HP:0002063)1.82716075
125Split foot (HP:0001839)1.82437927
126Lower limb muscle weakness (HP:0007340)1.79890780
127Slow saccadic eye movements (HP:0000514)1.75512878
128Testicular neoplasm (HP:0010788)1.75507642
129Absent speech (HP:0001344)1.74226960
130Hypokalemic alkalosis (HP:0001949)1.73271496
131Cerebral inclusion bodies (HP:0100314)1.72891877
132Hypsarrhythmia (HP:0002521)1.72192540
133Amblyopia (HP:0000646)1.71798653
134Hyperaldosteronism (HP:0000859)1.70919909
135Abnormality of renin-angiotensin system (HP:0000847)1.70720340
136Lower limb asymmetry (HP:0100559)1.70615870
137Aqueductal stenosis (HP:0002410)1.69977322
138Neurofibrillary tangles (HP:0002185)1.69885973
139Polydipsia (HP:0001959)1.69104262
140Abnormal drinking behavior (HP:0030082)1.69104262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.93382695
2MAP3K93.26762854
3EPHA42.83557405
4MAP3K42.40938956
5DAPK22.37468088
6RIPK42.33997317
7PRKD32.32126751
8PAK62.24527285
9STK382.18960099
10CAMKK12.11095769
11MINK12.08805466
12NTRK22.05811112
13KSR21.89030254
14AKT31.84157785
15SIK21.84033016
16MARK11.83754928
17RIPK11.82270302
18LATS21.81147864
19MAP3K131.71695750
20WNK11.67716915
21CAMK1G1.62738526
22CASK1.57932190
23MAP2K71.57042121
24TAOK11.53053156
25CAMKK21.50845661
26PRKCH1.46542228
27SGK31.43065217
28CDK51.40105807
29MAP2K41.40104634
30PNCK1.38471327
31TYRO31.38013052
32SGK2231.35931425
33SGK4941.35931425
34SGK21.32588750
35NTRK11.30548172
36WNK31.29684759
37NEK61.26889656
38FES1.26582808
39ARAF1.21714401
40OXSR11.20070914
41MAP3K71.17304195
42PDK11.16728063
43WNK41.16344653
44DAPK11.15527895
45MAP3K21.08586447
46PINK11.08240692
47GRK51.07985769
48SIK11.07588939
49ALK1.06994545
50TAOK21.06100972
51PRKCG1.05438145
52STK111.04766207
53TNIK1.03141488
54PRPF4B1.02437986
55CAMK11.01238440
56KSR11.00284058
57SGK10.99243287
58RET0.97174920
59LMTK20.95875536
60PDK20.94365985
61MARK20.87882331
62PDPK10.87846888
63PTK2B0.81694972
64GRK10.80184525
65ICK0.78476168
66CDC42BPA0.78155531
67CAMK1D0.74335408
68JAK10.72774061
69PHKG20.71561517
70PHKG10.71561517
71PLK20.71427004
72CAMK40.71052441
73TRIB30.71004416
74CAMK2G0.65250727
75MAP3K10.62859657
76CAMK2A0.62129957
77UHMK10.61854396
78RPS6KA30.61515421
79TNK20.60796402
80PDK30.57121633
81PDK40.57121633
82IRAK20.56831312
83CDK190.55499652
84FYN0.54899314
85RAF10.54583346
86MAP3K120.54506144
87MAPK100.53825691
88PRKCZ0.51698445
89EEF2K0.50702508
90DMPK0.49953954
91MST1R0.49709979
92ERN10.49543151
93MAPK120.49186081
94DYRK1A0.48340798
95CDK150.47909442
96BMPR20.47242243
97MAPK130.47130180
98ROCK20.46847723
99CDK180.45783587
100PRKCB0.44154723
101CAMK2D0.43543772
102MAP2K10.43459356
103JAK20.42687725
104FGFR30.42510190
105STK390.42239986
106MAP3K140.42082769
107FGFR20.42020728
108DDR20.41294474
109PTK20.40545180
110CAMK2B0.39394870
111PDGFRA0.38544276
112CDK11A0.38352046
113BMX0.37884398
114MAP2K20.37473324
115SCYL20.37276766
116MTOR0.37228610
117CDK140.37102992
118MAPK80.36361636
119PAK30.36089503
120HIPK20.35286512
121SRC0.34813334
122PRKD20.34474161
123TXK0.34061878
124BRAF0.33938619
125HCK0.33437971

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.67651405
2Nicotine addiction_Homo sapiens_hsa050332.75080901
3Synaptic vesicle cycle_Homo sapiens_hsa047212.67721095
4Long-term potentiation_Homo sapiens_hsa047202.28062753
5Circadian entrainment_Homo sapiens_hsa047132.26172774
6Glutamatergic synapse_Homo sapiens_hsa047242.24481392
7Olfactory transduction_Homo sapiens_hsa047402.22213848
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20724207
9GABAergic synapse_Homo sapiens_hsa047272.14694331
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08911949
11Morphine addiction_Homo sapiens_hsa050322.03161101
12Salivary secretion_Homo sapiens_hsa049701.95651224
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95182723
14Gastric acid secretion_Homo sapiens_hsa049711.85705917
15Amphetamine addiction_Homo sapiens_hsa050311.84200668
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83619247
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80087909
18Vitamin B6 metabolism_Homo sapiens_hsa007501.71794713
19Dopaminergic synapse_Homo sapiens_hsa047281.66906096
20Insulin secretion_Homo sapiens_hsa049111.66813913
21Cholinergic synapse_Homo sapiens_hsa047251.63635377
22Renin secretion_Homo sapiens_hsa049241.47321600
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45374346
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39872585
25Oxytocin signaling pathway_Homo sapiens_hsa049211.39400963
26Long-term depression_Homo sapiens_hsa047301.37992779
27Type II diabetes mellitus_Homo sapiens_hsa049301.36125648
28Taste transduction_Homo sapiens_hsa047421.30293620
29Calcium signaling pathway_Homo sapiens_hsa040201.26170352
30GnRH signaling pathway_Homo sapiens_hsa049121.25993519
31Cocaine addiction_Homo sapiens_hsa050301.22271022
32cAMP signaling pathway_Homo sapiens_hsa040241.22205871
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17978165
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15409707
35Nitrogen metabolism_Homo sapiens_hsa009101.14064911
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11777889
37Serotonergic synapse_Homo sapiens_hsa047261.11157397
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08201399
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06063369
40Steroid biosynthesis_Homo sapiens_hsa001001.02119669
41Glioma_Homo sapiens_hsa052140.98851996
42Estrogen signaling pathway_Homo sapiens_hsa049150.98308585
43Collecting duct acid secretion_Homo sapiens_hsa049660.98183741
44Thyroid hormone synthesis_Homo sapiens_hsa049180.96894997
45Prion diseases_Homo sapiens_hsa050200.95182505
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95181930
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.92902791
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.91924741
49Pancreatic secretion_Homo sapiens_hsa049720.91508869
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90920929
51Gap junction_Homo sapiens_hsa045400.89764715
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86657462
53ErbB signaling pathway_Homo sapiens_hsa040120.84660823
54Choline metabolism in cancer_Homo sapiens_hsa052310.83886991
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82869604
56Inositol phosphate metabolism_Homo sapiens_hsa005620.82005272
57mTOR signaling pathway_Homo sapiens_hsa041500.79762075
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77737907
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.77050187
60VEGF signaling pathway_Homo sapiens_hsa043700.76126314
61MAPK signaling pathway_Homo sapiens_hsa040100.75444683
62Bile secretion_Homo sapiens_hsa049760.73266367
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.72236424
64Dilated cardiomyopathy_Homo sapiens_hsa054140.68904538
65T cell receptor signaling pathway_Homo sapiens_hsa046600.68458758
66Chemokine signaling pathway_Homo sapiens_hsa040620.66110364
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65657547
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65434176
69Circadian rhythm_Homo sapiens_hsa047100.62617060
70Melanogenesis_Homo sapiens_hsa049160.62590656
71Mineral absorption_Homo sapiens_hsa049780.58963338
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58226652
73Arginine biosynthesis_Homo sapiens_hsa002200.58045406
74Vibrio cholerae infection_Homo sapiens_hsa051100.57509745
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.57436006
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57375278
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57203841
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57077902
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56373744
80Endocytosis_Homo sapiens_hsa041440.55609721
81Type I diabetes mellitus_Homo sapiens_hsa049400.55592424
82Fatty acid biosynthesis_Homo sapiens_hsa000610.55529320
83Axon guidance_Homo sapiens_hsa043600.54513573
84Ovarian steroidogenesis_Homo sapiens_hsa049130.52464102
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52442301
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52384225
87Glucagon signaling pathway_Homo sapiens_hsa049220.52110472
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50826879
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50304995
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49919501
91Osteoclast differentiation_Homo sapiens_hsa043800.49845043
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.49420203
93Rap1 signaling pathway_Homo sapiens_hsa040150.48865533
94Ras signaling pathway_Homo sapiens_hsa040140.48845241
95Prolactin signaling pathway_Homo sapiens_hsa049170.48396733
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46406235
97Cardiac muscle contraction_Homo sapiens_hsa042600.45660517
98Non-small cell lung cancer_Homo sapiens_hsa052230.45277656
99Oocyte meiosis_Homo sapiens_hsa041140.45135729
100Alcoholism_Homo sapiens_hsa050340.40845143
101Wnt signaling pathway_Homo sapiens_hsa043100.40783123
102Endometrial cancer_Homo sapiens_hsa052130.40577179
103AMPK signaling pathway_Homo sapiens_hsa041520.40534363
104Tuberculosis_Homo sapiens_hsa051520.36974989
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36730931
106Insulin signaling pathway_Homo sapiens_hsa049100.35816882
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35351200
108African trypanosomiasis_Homo sapiens_hsa051430.33786595
109Renal cell carcinoma_Homo sapiens_hsa052110.33665184
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.33287509
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.33099453
112HIF-1 signaling pathway_Homo sapiens_hsa040660.32766540
113ABC transporters_Homo sapiens_hsa020100.29567389
114Hippo signaling pathway_Homo sapiens_hsa043900.26646738
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22744686

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