GRAMD1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.07404126
2L-phenylalanine catabolic process (GO:0006559)7.07404126
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.61668505
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.57061395
5L-phenylalanine metabolic process (GO:0006558)6.57061395
6axonemal dynein complex assembly (GO:0070286)6.38037121
7aromatic amino acid family catabolic process (GO:0009074)6.28311301
8cilium or flagellum-dependent cell motility (GO:0001539)6.28261957
9cilium movement (GO:0003341)6.08566413
10epithelial cilium movement (GO:0003351)5.98471332
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.85377520
12tryptophan catabolic process (GO:0006569)5.63897276
13indole-containing compound catabolic process (GO:0042436)5.63897276
14indolalkylamine catabolic process (GO:0046218)5.63897276
15bile acid biosynthetic process (GO:0006699)5.60735974
16high-density lipoprotein particle remodeling (GO:0034375)5.42853278
17tryptophan metabolic process (GO:0006568)5.37104904
18kynurenine metabolic process (GO:0070189)5.35154233
19urea cycle (GO:0000050)5.31158113
20urea metabolic process (GO:0019627)5.31158113
21sulfur amino acid catabolic process (GO:0000098)5.22625392
22alpha-linolenic acid metabolic process (GO:0036109)5.17195434
23glyoxylate metabolic process (GO:0046487)5.10152199
24cysteine metabolic process (GO:0006534)5.09737953
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02061087
26sensory perception of smell (GO:0007608)4.98914284
27regulation of fibrinolysis (GO:0051917)4.97291484
28regulation of protein activation cascade (GO:2000257)4.95840475
29peptidyl-glutamic acid carboxylation (GO:0017187)4.95508153
30protein carboxylation (GO:0018214)4.95508153
31negative regulation of fibrinolysis (GO:0051918)4.92857349
32complement activation, alternative pathway (GO:0006957)4.87757240
33nitrogen cycle metabolic process (GO:0071941)4.85104624
34reverse cholesterol transport (GO:0043691)4.83893295
35bile acid metabolic process (GO:0008206)4.80021231
36regulation of complement activation (GO:0030449)4.60932767
37serine family amino acid catabolic process (GO:0009071)4.59631634
38regulation of triglyceride catabolic process (GO:0010896)4.59626835
39plasma lipoprotein particle remodeling (GO:0034369)4.54404669
40protein-lipid complex remodeling (GO:0034368)4.54404669
41macromolecular complex remodeling (GO:0034367)4.54404669
42phospholipid efflux (GO:0033700)4.54051800
43homocysteine metabolic process (GO:0050667)4.51269216
44regulation of cholesterol esterification (GO:0010872)4.47586181
45aromatic amino acid family metabolic process (GO:0009072)4.46698698
46axoneme assembly (GO:0035082)4.46025861
47tyrosine metabolic process (GO:0006570)4.44209101
48imidazole-containing compound metabolic process (GO:0052803)4.39196841
49drug metabolic process (GO:0017144)4.33736831
50alkaloid metabolic process (GO:0009820)4.32261938
51amino-acid betaine metabolic process (GO:0006577)4.29188443
52triglyceride homeostasis (GO:0070328)4.28494313
53acylglycerol homeostasis (GO:0055090)4.28494313
54cholesterol efflux (GO:0033344)4.25185184
55alpha-amino acid catabolic process (GO:1901606)4.20199104
56omega-hydroxylase P450 pathway (GO:0097267)4.18135954
57bile acid and bile salt transport (GO:0015721)4.17861390
58regulation of cilium movement (GO:0003352)4.15316453
59negative regulation of sterol transport (GO:0032372)4.13325717
60negative regulation of cholesterol transport (GO:0032375)4.13325717
61cellular glucuronidation (GO:0052695)4.12663240
62drug catabolic process (GO:0042737)4.10060591
63lysine metabolic process (GO:0006553)4.09356252
64lysine catabolic process (GO:0006554)4.09356252
65indolalkylamine metabolic process (GO:0006586)4.01361136
66plasma lipoprotein particle assembly (GO:0034377)3.99042816
67intestinal cholesterol absorption (GO:0030299)3.92494668
68ethanol oxidation (GO:0006069)3.91865568
69very-low-density lipoprotein particle assembly (GO:0034379)3.90889587
70cellular amino acid catabolic process (GO:0009063)3.88451020
71plasma lipoprotein particle clearance (GO:0034381)3.86432511
72fibrinolysis (GO:0042730)3.85926725
73coenzyme catabolic process (GO:0009109)3.85525013
74cellular ketone body metabolic process (GO:0046950)3.83975781
75negative regulation of lipase activity (GO:0060192)3.83525215
76cellular biogenic amine catabolic process (GO:0042402)3.80572046
77amine catabolic process (GO:0009310)3.80572046
78benzene-containing compound metabolic process (GO:0042537)3.78368592
79glutamate metabolic process (GO:0006536)3.77768813
80cellular modified amino acid catabolic process (GO:0042219)3.74692463
81motile cilium assembly (GO:0044458)3.69579744
82phenylpropanoid metabolic process (GO:0009698)3.67167185
83regulation of guanylate cyclase activity (GO:0031282)3.64451460
84low-density lipoprotein particle remodeling (GO:0034374)3.63817684
85glycine metabolic process (GO:0006544)3.61863907
86uronic acid metabolic process (GO:0006063)3.60360593
87glucuronate metabolic process (GO:0019585)3.60360593
88plasma lipoprotein particle organization (GO:0071827)3.59092419
89positive regulation of lipoprotein lipase activity (GO:0051006)3.58833412
90positive regulation of triglyceride lipase activity (GO:0061365)3.58833412
91flavonoid metabolic process (GO:0009812)3.56940938
92serine family amino acid metabolic process (GO:0009069)3.56178538
93regulation of bile acid biosynthetic process (GO:0070857)3.54279048
94phospholipid homeostasis (GO:0055091)3.51883958
95protein-lipid complex assembly (GO:0065005)3.51148973
96complement activation, classical pathway (GO:0006958)3.50460353
97heme transport (GO:0015886)3.49460859
98blood coagulation, intrinsic pathway (GO:0007597)3.49096983
99negative regulation of protein activation cascade (GO:2000258)3.46371863
100cholesterol homeostasis (GO:0042632)3.44863271
101ethanol metabolic process (GO:0006067)3.44296186
102arginine metabolic process (GO:0006525)3.43810570
103carboxylic acid catabolic process (GO:0046395)3.43491438
104organic acid catabolic process (GO:0016054)3.43491438
105short-chain fatty acid metabolic process (GO:0046459)3.43355801
106cytolysis (GO:0019835)3.42850519
107exogenous drug catabolic process (GO:0042738)3.42825144
108positive regulation of lipid catabolic process (GO:0050996)3.40524533
109complement activation (GO:0006956)3.40375473
110opsonization (GO:0008228)3.40284109
111drug transmembrane transport (GO:0006855)3.40126961
112cofactor catabolic process (GO:0051187)3.39691068
113protein activation cascade (GO:0072376)3.39562004
114sterol homeostasis (GO:0055092)3.38342274
115intraciliary transport (GO:0042073)3.38047680
116epoxygenase P450 pathway (GO:0019373)3.37578204
117angiotensin maturation (GO:0002003)3.36534709
118cilium organization (GO:0044782)3.30081878
119protein localization to cilium (GO:0061512)3.27662828
120response to nitrosative stress (GO:0051409)3.26053274
121cilium assembly (GO:0042384)3.22618967
122photoreceptor cell maintenance (GO:0045494)3.16014082
123positive regulation of guanylate cyclase activity (GO:0031284)3.15069952
124cilium morphogenesis (GO:0060271)3.12388598
125fat-soluble vitamin biosynthetic process (GO:0042362)3.09562158
126oxidative demethylation (GO:0070989)3.09206396
127primary alcohol catabolic process (GO:0034310)3.08247175
128L-fucose catabolic process (GO:0042355)3.06161641
129fucose catabolic process (GO:0019317)3.06161641
130L-fucose metabolic process (GO:0042354)3.06161641
131auditory receptor cell differentiation (GO:0042491)3.05539150
132xenobiotic catabolic process (GO:0042178)3.03750504
133drug transport (GO:0015893)3.03335236
134iron coordination entity transport (GO:1901678)2.94156517
135negative regulation of humoral immune response (GO:0002921)2.87496558
136negative regulation of complement activation (GO:0045916)2.86003019
137nucleobase catabolic process (GO:0046113)2.83459175
138phosphatidylcholine acyl-chain remodeling (GO:0036151)2.82561747
139vitamin transmembrane transport (GO:0035461)2.80799147
140transepithelial transport (GO:0070633)2.80698563
141organic cation transport (GO:0015695)2.80059131
142hormone catabolic process (GO:0042447)2.75565889
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.71983799
144vitamin transport (GO:0051180)2.68113162
145C4-dicarboxylate transport (GO:0015740)2.67905351
146regulation of lipoprotein metabolic process (GO:0050746)2.66334620
147regulation of protein glycosylation (GO:0060049)2.66062957
148xenobiotic metabolic process (GO:0006805)2.64852237
149ketone body metabolic process (GO:1902224)2.63825316
150arginine catabolic process (GO:0006527)2.63220881
151regulation of microtubule-based movement (GO:0060632)2.62668514
152primary alcohol metabolic process (GO:0034308)2.62457150
153phenol-containing compound catabolic process (GO:0019336)2.62019954
154lipoprotein transport (GO:0042953)2.61765986
155excretion (GO:0007588)2.60655887
156phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.58011897
157retinal cone cell development (GO:0046549)2.56226239
158one-carbon compound transport (GO:0019755)2.55592494
159intestinal absorption (GO:0050892)2.55478145
160vitamin biosynthetic process (GO:0009110)2.53356512
161gamma-aminobutyric acid transport (GO:0015812)2.52322993
162sodium ion homeostasis (GO:0055078)2.51501681
163positive regulation of fatty acid transport (GO:2000193)2.51209838
164behavioral response to nicotine (GO:0035095)2.48866620
165diterpenoid biosynthetic process (GO:0016102)2.48748544
166digestion (GO:0007586)2.48721455
167purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.48352723
1683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.48352723
169cellular component assembly involved in morphogenesis (GO:0010927)2.48041074
170sulfation (GO:0051923)2.46923047
171phosphatidylinositol acyl-chain remodeling (GO:0036149)2.46474600
172thyroid hormone metabolic process (GO:0042403)2.45074508
173microtubule bundle formation (GO:0001578)2.43814617
174positive regulation of icosanoid secretion (GO:0032305)2.43349488
175regulation of cGMP biosynthetic process (GO:0030826)2.43322477
176parturition (GO:0007567)2.41414267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.84346587
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.25220542
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.18220541
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.10423693
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.77972959
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.68246000
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.46412289
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.46196417
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.23239582
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.01248185
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53104528
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42766795
13GBX2_23144817_ChIP-Seq_PC3_Human2.32267389
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32267244
15IGF1R_20145208_ChIP-Seq_DFB_Human2.17132415
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14102774
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.91400002
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91144029
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90956531
20ZNF274_21170338_ChIP-Seq_K562_Hela1.87799518
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83439829
22* P300_19829295_ChIP-Seq_ESCs_Human1.81614420
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72128865
24ER_23166858_ChIP-Seq_MCF-7_Human1.68685530
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66733069
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.65984281
27SMAD4_21799915_ChIP-Seq_A2780_Human1.64762289
28GATA1_22025678_ChIP-Seq_K562_Human1.63893524
29FUS_26573619_Chip-Seq_HEK293_Human1.63805385
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62915678
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61088703
32* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60735192
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56363214
34* STAT3_23295773_ChIP-Seq_U87_Human1.56052012
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54887606
36CBP_20019798_ChIP-Seq_JUKART_Human1.54887606
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.53277159
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51227003
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.48874301
40AR_25329375_ChIP-Seq_VCAP_Human1.48531557
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47412702
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45494783
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44536484
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40897248
45* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39434448
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38988815
47EWS_26573619_Chip-Seq_HEK293_Human1.37695296
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35734027
49TCF4_23295773_ChIP-Seq_U87_Human1.35605454
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34019058
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33338453
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32866035
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30948246
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29324743
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27890376
56RUNX2_22187159_ChIP-Seq_PCA_Human1.26616732
57HTT_18923047_ChIP-ChIP_STHdh_Human1.26437066
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26274097
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26037724
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25634531
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25194218
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24886203
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.23740424
64TP53_18474530_ChIP-ChIP_U2OS_Human1.23349619
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23142436
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.22435457
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20799618
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20678321
69RXR_22108803_ChIP-Seq_LS180_Human1.19003583
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.18048253
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17767887
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.17026369
73* NANOG_19829295_ChIP-Seq_ESCs_Human1.16948835
74* SOX2_19829295_ChIP-Seq_ESCs_Human1.16948835
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15326948
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14927304
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14559640
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.14559640
79HNF4A_19822575_ChIP-Seq_HepG2_Human1.14451411
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.14399294
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13813710
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11494253
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11194742
84TP53_16413492_ChIP-PET_HCT116_Human1.08872980
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08527810
86ERG_20517297_ChIP-Seq_VCAP_Human1.08413077
87TBL1_22424771_ChIP-Seq_293T_Human1.07815191
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07617350
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.07586191
90CJUN_26792858_Chip-Seq_BT549_Human1.07269325
91* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06789910
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06479859
93P53_22387025_ChIP-Seq_ESCs_Mouse1.06336180
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04561649
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01991524
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99442387
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98904140
98GATA4_25053715_ChIP-Seq_YYC3_Human0.98567941
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98395890
100TAF15_26573619_Chip-Seq_HEK293_Human0.97928334
101STAT1_17558387_ChIP-Seq_HELA_Human0.97412045
102BCAT_22108803_ChIP-Seq_LS180_Human0.95886434
103GATA3_21867929_ChIP-Seq_TH1_Mouse0.93199481
104CLOCK_20551151_ChIP-Seq_293T_Human0.89914555
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87612383
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87180494
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84708594
108VDR_22108803_ChIP-Seq_LS180_Human0.83968121
109ZNF263_19887448_ChIP-Seq_K562_Human0.81244812
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81242747
111* CDX2_22108803_ChIP-Seq_LS180_Human0.80714767
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80503606
113* CEBPB_22108803_ChIP-Seq_LS180_Human0.79606580
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78230334
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.78081310
116* FOXA1_25552417_ChIP-Seq_VCAP_Human0.75826048
117CBP_21632823_ChIP-Seq_H3396_Human0.74692249
118AR_20517297_ChIP-Seq_VCAP_Human0.74382354
119P53_21459846_ChIP-Seq_SAOS-2_Human0.73786762
120OCT4_20526341_ChIP-Seq_ESCs_Human0.73113328
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72832202
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.72786468
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71677140
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71550167
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71084235
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.70350799
127TCF4_22108803_ChIP-Seq_LS180_Human0.69384823
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.68070084
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.67514028
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67348199
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.67320291
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.65532605
133SOX2_22085726_ChIP-Seq_NPCs_Mouse0.65496511
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.65029912
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.64941045
136TP63_23658742_ChIP-Seq_EP156T_Human0.64322600
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.64026499
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.63330067
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.62352592
140GATA3_21867929_ChIP-Seq_CD8_Mouse0.62306954
141NANOG_20526341_ChIP-Seq_ESCs_Human0.62241900
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62146170
143NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.61318473
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.60982488
145CRX_20693478_ChIP-Seq_RETINA_Mouse0.60555203
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60547496
147EZH2_22144423_ChIP-Seq_EOC_Human0.59642026
148* TAF2_19829295_ChIP-Seq_ESCs_Human0.59568430
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.59560908
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.58957635
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.57868424
152* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57485641
153NCOR_22424771_ChIP-Seq_293T_Human0.57356013
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.57021240
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56955099
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.55898043
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.54979997
158MYC_19915707_ChIP-ChIP_AK7_Human0.54679044
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54309128
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.53932485
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.53129626
162BCOR_27268052_Chip-Seq_Bcells_Human0.52443319
163PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.52375716
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.52317896
165TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.52083828
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.52083828
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.51442402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.58617600
2MP0005360_urolithiasis7.04327394
3MP0005365_abnormal_bile_salt5.87843099
4MP0005085_abnormal_gallbladder_physiolo5.86238261
5MP0008875_abnormal_xenobiotic_pharmacok5.04851596
6MP0001984_abnormal_olfaction4.68570688
7MP0003252_abnormal_bile_duct4.31067138
8MP0003806_abnormal_nucleotide_metabolis4.29101228
9MP0010329_abnormal_lipoprotein_level3.23592188
10MP0002653_abnormal_ependyma_morphology2.92320715
11MP0004043_abnormal_pH_regulation2.76527956
12MP0001666_abnormal_nutrient_absorption2.72734938
13MP0003195_calcinosis2.69689531
14MP0009840_abnormal_foam_cell2.65220331
15MP0005083_abnormal_biliary_tract2.47708612
16MP0003183_abnormal_peptide_metabolism2.29195635
17MP0005332_abnormal_amino_acid2.17742660
18MP0000609_abnormal_liver_physiology2.05172662
19MP0004885_abnormal_endolymph2.02753460
20MP0005551_abnormal_eye_electrophysiolog2.02459865
21MP0004019_abnormal_vitamin_homeostasis2.02352960
22MP0003191_abnormal_cellular_cholesterol1.99005139
23MP0000383_abnormal_hair_follicle1.98303414
24MP0001485_abnormal_pinna_reflex1.97697397
25MP0002138_abnormal_hepatobiliary_system1.96384926
26MP0002277_abnormal_respiratory_mucosa1.90763489
27MP0005410_abnormal_fertilization1.87440455
28MP0002118_abnormal_lipid_homeostasis1.86374022
29MP0005451_abnormal_body_composition1.73851930
30MP0003868_abnormal_feces_composition1.67742185
31MP0005319_abnormal_enzyme/_coenzyme1.65073947
32MP0010678_abnormal_skin_adnexa1.64723699
33MP0002638_abnormal_pupillary_reflex1.62147698
34MP0003283_abnormal_digestive_organ1.62009801
35MP0003136_yellow_coat_color1.60373514
36MP0010386_abnormal_urinary_bladder1.53925530
37MP0004147_increased_porphyrin_level1.48758669
38MP0001764_abnormal_homeostasis1.44506011
39MP0008872_abnormal_physiological_respon1.41010959
40MP0002909_abnormal_adrenal_gland1.40996009
41MP0005584_abnormal_enzyme/coenzyme_acti1.39853141
42MP0001501_abnormal_sleep_pattern1.37766099
43MP0009379_abnormal_foot_pigmentation1.34914417
44MP0009697_abnormal_copulation1.33845744
45MP0000569_abnormal_digit_pigmentation1.32087684
46MP0005084_abnormal_gallbladder_morpholo1.28640526
47MP0002254_reproductive_system_inflammat1.28587177
48MP0009643_abnormal_urine_homeostasis1.24926721
49MP0003011_delayed_dark_adaptation1.24917221
50MP0002928_abnormal_bile_duct1.24033400
51MP0005253_abnormal_eye_physiology1.19351240
52MP0001486_abnormal_startle_reflex1.17559838
53MP0006292_abnormal_olfactory_placode1.17330676
54MP0005220_abnormal_exocrine_pancreas1.12559531
55MP0006054_spinal_hemorrhage1.10036939
56MP0002938_white_spotting1.09684731
57MP0000462_abnormal_digestive_system1.09661397
58MP0005647_abnormal_sex_gland1.08945849
59MP0000516_abnormal_urinary_system1.08543096
60MP0005367_renal/urinary_system_phenotyp1.08543096
61MP0001664_abnormal_digestion1.08523373
62MP0001986_abnormal_taste_sensitivity1.08470356
63MP0000026_abnormal_inner_ear1.07253794
64MP0004381_abnormal_hair_follicle1.02337823
65MP0005646_abnormal_pituitary_gland0.99413771
66MP0002876_abnormal_thyroid_physiology0.98725030
67MP0001440_abnormal_grooming_behavior0.98512711
68MP0004270_analgesia0.96340584
69MP0005636_abnormal_mineral_homeostasis0.95757568
70MP0009764_decreased_sensitivity_to0.95593183
71MP0003656_abnormal_erythrocyte_physiolo0.95466114
72MP0000598_abnormal_liver_morphology0.95419101
73MP0002272_abnormal_nervous_system0.94983920
74MP0003878_abnormal_ear_physiology0.94700426
75MP0005377_hearing/vestibular/ear_phenot0.94700426
76MP0003186_abnormal_redox_activity0.94668502
77MP0005174_abnormal_tail_pigmentation0.93577937
78MP0000631_abnormal_neuroendocrine_gland0.92872647
79MP0001529_abnormal_vocalization0.92396367
80MP0004133_heterotaxia0.92146080
81MP0009763_increased_sensitivity_to0.90720660
82MP0001346_abnormal_lacrimal_gland0.90333441
83MP0002877_abnormal_melanocyte_morpholog0.87988695
84MP0009780_abnormal_chondrocyte_physiolo0.87832838
85MP0002102_abnormal_ear_morphology0.86452073
86MP0002168_other_aberrant_phenotype0.85607052
87MP0002009_preneoplasia0.85227286
88MP0009745_abnormal_behavioral_response0.85213155
89MP0002557_abnormal_social/conspecific_i0.84259678
90MP0001293_anophthalmia0.82759292
91MP0002078_abnormal_glucose_homeostasis0.81694617
92MP0010234_abnormal_vibrissa_follicle0.80296495
93MP0003633_abnormal_nervous_system0.80052320
94MP0005195_abnormal_posterior_eye0.80023059
95MP0003787_abnormal_imprinting0.79184576
96MP0006036_abnormal_mitochondrial_physio0.78931181
97MP0009642_abnormal_blood_homeostasis0.78041328
98MP0000604_amyloidosis0.78017639
99MP0001963_abnormal_hearing_physiology0.77641988
100MP0002233_abnormal_nose_morphology0.77276862
101MP0005389_reproductive_system_phenotype0.76934240
102MP0009765_abnormal_xenobiotic_induced0.76775012
103MP0000230_abnormal_systemic_arterial0.76633322
104MP0008469_abnormal_protein_level0.76575712
105MP0002572_abnormal_emotion/affect_behav0.76545353
106MP0004142_abnormal_muscle_tone0.76522145
107MP0002132_abnormal_respiratory_system0.76240729
108MP0003718_maternal_effect0.75713898
109MP0004924_abnormal_behavior0.72705288
110MP0005386_behavior/neurological_phenoty0.72705288
111MP0005408_hypopigmentation0.71342439
112MP0005248_abnormal_Harderian_gland0.70466624
113MP0002971_abnormal_brown_adipose0.69913236
114MP0003705_abnormal_hypodermis_morpholog0.66569805
115MP0002796_impaired_skin_barrier0.66022931
116MP0010368_abnormal_lymphatic_system0.65648190
117MP0005187_abnormal_penis_morphology0.62309045
118MP0008789_abnormal_olfactory_epithelium0.60574351
119MP0005334_abnormal_fat_pad0.59283050
120MP0005376_homeostasis/metabolism_phenot0.58841170
121MP0005379_endocrine/exocrine_gland_phen0.57532001
122MP0004264_abnormal_extraembryonic_tissu0.57138882
123MP0005448_abnormal_energy_balance0.56441905
124MP0002060_abnormal_skin_morphology0.55331563
125MP0002098_abnormal_vibrissa_morphology0.53604836
126MP0005535_abnormal_body_temperature0.52778198
127MP0006035_abnormal_mitochondrial_morpho0.52747085
128MP0004782_abnormal_surfactant_physiolog0.51401066
129MP0004130_abnormal_muscle_cell0.51118331
130MP0001944_abnormal_pancreas_morphology0.51117357
131MP0005670_abnormal_white_adipose0.50465225
132MP0003698_abnormal_male_reproductive0.48479987
133MP0000372_irregular_coat_pigmentation0.48415026
134MP0001661_extended_life_span0.48335649
135MP0002693_abnormal_pancreas_physiology0.46533491
136MP0005395_other_phenotype0.45703921
137MP0001929_abnormal_gametogenesis0.44915098
138MP0003953_abnormal_hormone_level0.44782976
139MP0005499_abnormal_olfactory_system0.44114283
140MP0005394_taste/olfaction_phenotype0.44114283
141MP0003300_gastrointestinal_ulcer0.43889970
142MP0000427_abnormal_hair_cycle0.42746279
143MP0006082_CNS_inflammation0.42481880
144MP0000639_abnormal_adrenal_gland0.41938724
145MP0003329_amyloid_beta_deposits0.40315523
146MP0002136_abnormal_kidney_physiology0.40291062
147MP0008874_decreased_physiological_sensi0.39546953
148MP0001765_abnormal_ion_homeostasis0.39472179
149MP0002160_abnormal_reproductive_system0.38734871
150MP0000579_abnormal_nail_morphology0.38727280
151MP0002822_catalepsy0.38621114
152MP0009053_abnormal_anal_canal0.38266242
153MP0000538_abnormal_urinary_bladder0.37213906
154MP0005266_abnormal_metabolism0.37116894
155MP0000566_synostosis0.37088270
156MP0001756_abnormal_urination0.36765206
157MP0005464_abnormal_platelet_physiology0.35939642
158MP0009384_cardiac_valve_regurgitation0.35291271
159MP0002161_abnormal_fertility/fecundity0.35170019

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.74250404
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.67314903
3Deep venous thrombosis (HP:0002625)6.60471840
4Prolonged partial thromboplastin time (HP:0003645)6.15223386
5Hypobetalipoproteinemia (HP:0003563)6.04127605
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02198489
7Xanthomatosis (HP:0000991)5.63226849
8Hyperlipoproteinemia (HP:0010980)4.81671370
9Complement deficiency (HP:0004431)4.68500497
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.66492121
11Hypolipoproteinemia (HP:0010981)4.50815396
12Joint hemorrhage (HP:0005261)4.43523160
13True hermaphroditism (HP:0010459)4.27797465
14Hyperglycinemia (HP:0002154)4.23124738
15Abnormality of the common coagulation pathway (HP:0010990)4.21091344
16Conjugated hyperbilirubinemia (HP:0002908)4.15079071
17Pancreatic fibrosis (HP:0100732)4.14660386
18Epidermoid cyst (HP:0200040)4.14078793
19Pancreatic cysts (HP:0001737)4.12317030
20Ketosis (HP:0001946)4.11172605
21Fat malabsorption (HP:0002630)4.06381984
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99537009
23Hypoalphalipoproteinemia (HP:0003233)3.89297242
24Hyperammonemia (HP:0001987)3.85470653
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.70506487
26Hyperglycinuria (HP:0003108)3.64203881
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.63384350
28Abnormality of the intrinsic pathway (HP:0010989)3.61379295
29Hypoglycemic coma (HP:0001325)3.58354333
30Bronchiectasis (HP:0002110)3.55191934
31Hyperactive renin-angiotensin system (HP:0000841)3.49969999
32Abnormality of serine family amino acid metabolism (HP:0010894)3.47724781
33Abnormality of glycine metabolism (HP:0010895)3.47724781
34Abnormal respiratory motile cilium physiology (HP:0012261)3.37555524
35Hypercholesterolemia (HP:0003124)3.33431120
36Abnormality of complement system (HP:0005339)3.32259723
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29953098
38Abnormality of methionine metabolism (HP:0010901)3.27298951
39Cystic liver disease (HP:0006706)3.20356403
40Chronic bronchitis (HP:0004469)3.10014202
41Hyperbilirubinemia (HP:0002904)3.07491912
42Ketoacidosis (HP:0001993)3.06070200
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04604370
44Abnormality of pyrimidine metabolism (HP:0004353)3.03349230
45Nephronophthisis (HP:0000090)3.02089110
46Metabolic alkalosis (HP:0200114)3.00048582
47Abnormality of the renal medulla (HP:0100957)2.97520288
48Occipital encephalocele (HP:0002085)2.97205996
49Steatorrhea (HP:0002570)2.93398422
50Abnormality of chloride homeostasis (HP:0011422)2.89342716
51Medial flaring of the eyebrow (HP:0010747)2.88804885
52Abnormality of the renal cortex (HP:0011035)2.86621925
53Hepatocellular carcinoma (HP:0001402)2.86053470
54Abnormality of renin-angiotensin system (HP:0000847)2.82467635
55Rhinitis (HP:0012384)2.81439185
56Decreased circulating renin level (HP:0003351)2.81175030
57Hyperventilation (HP:0002883)2.81077984
58Spontaneous abortion (HP:0005268)2.80933950
59Hypochromic microcytic anemia (HP:0004840)2.79230801
60Poikilocytosis (HP:0004447)2.79085687
61Abnormality of nucleobase metabolism (HP:0010932)2.78960215
62Abnormality of fatty-acid metabolism (HP:0004359)2.78827979
63Amyloidosis (HP:0011034)2.75440170
64Vascular calcification (HP:0004934)2.74530518
65Abnormality of proline metabolism (HP:0010907)2.68180618
66Hydroxyprolinuria (HP:0003080)2.68180618
67Abnormality of purine metabolism (HP:0004352)2.66765708
68Malnutrition (HP:0004395)2.66432458
69Delayed CNS myelination (HP:0002188)2.62150591
70Acanthocytosis (HP:0001927)2.59291222
71Hyperaldosteronism (HP:0000859)2.57960183
72Gait imbalance (HP:0002141)2.57535974
73Myocardial infarction (HP:0001658)2.56408530
74Chronic hepatic failure (HP:0100626)2.56375357
75Congenital primary aphakia (HP:0007707)2.52799890
76Glycosuria (HP:0003076)2.51232093
77Abnormality of urine glucose concentration (HP:0011016)2.51232093
78Metabolic acidosis (HP:0001942)2.50607150
79Abnormality of serum amino acid levels (HP:0003112)2.49881439
80Abnormal ciliary motility (HP:0012262)2.49134028
81Furrowed tongue (HP:0000221)2.46498785
82Alkalosis (HP:0001948)2.45562210
83Hypoglycemic seizures (HP:0002173)2.44006733
84Congenital hepatic fibrosis (HP:0002612)2.42446400
85Postaxial foot polydactyly (HP:0001830)2.41425272
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.39246828
87Decreased central vision (HP:0007663)2.37995412
88Cardiovascular calcification (HP:0011915)2.37376811
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.36713817
90Absent/shortened dynein arms (HP:0200106)2.36713817
91Chronic sinusitis (HP:0011109)2.36573533
92Hypokalemic alkalosis (HP:0001949)2.36118338
93Hemorrhage of the eye (HP:0011885)2.33301319
94Nephrogenic diabetes insipidus (HP:0009806)2.32904117
95Increased circulating renin level (HP:0000848)2.32793478
96Abnormal biliary tract physiology (HP:0012439)2.29334705
97Bile duct proliferation (HP:0001408)2.29334705
98Gout (HP:0001997)2.26354960
99Late onset (HP:0003584)2.24789083
100Pancreatitis (HP:0001733)2.24534966
101Cholecystitis (HP:0001082)2.22799936
102Abnormal gallbladder physiology (HP:0012438)2.22799936
103Tubulointerstitial nephritis (HP:0001970)2.21776117
104Tubular atrophy (HP:0000092)2.21157153
105Confusion (HP:0001289)2.21096789
106Neonatal onset (HP:0003623)2.20714129
107Abnormality of macular pigmentation (HP:0008002)2.20469193
108Enlarged kidneys (HP:0000105)2.20272599
109Male pseudohermaphroditism (HP:0000037)2.17396670
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16929778
111Dicarboxylic aciduria (HP:0003215)2.16929778
112Cerebral edema (HP:0002181)2.16868944
113Abnormal drinking behavior (HP:0030082)2.16385443
114Polydipsia (HP:0001959)2.16385443
115Abnormal respiratory epithelium morphology (HP:0012253)2.16364424
116Abnormal respiratory motile cilium morphology (HP:0005938)2.16364424
117Renal salt wasting (HP:0000127)2.14239176
118Large for gestational age (HP:0001520)2.11584488
119Skin nodule (HP:0200036)2.11356504
120Lethargy (HP:0001254)2.11254416
121Abnormality of the vitamin B12 metabolism (HP:0004341)2.10866648
122Renal cortical cysts (HP:0000803)2.09147090
123Sclerocornea (HP:0000647)2.09070115
124Nasal polyposis (HP:0100582)2.08269000
125Abnormality of vitamin B metabolism (HP:0004340)2.08010443
126Irritability (HP:0000737)2.05605626
127Genital tract atresia (HP:0001827)2.05598550
128Hyperinsulinemic hypoglycemia (HP:0000825)2.05305844
129Abnormality of vitamin metabolism (HP:0100508)2.04872164
130Recurrent gram-negative bacterial infections (HP:0005420)2.04846709
131Systemic lupus erythematosus (HP:0002725)2.04458411
132Abnormal urine output (HP:0012590)2.01053636
133Infertility (HP:0000789)2.00793895
134Polyuria (HP:0000103)2.00369718
135Abnormality of renal excretion (HP:0011036)1.99819474
136Congenital sensorineural hearing impairment (HP:0008527)1.96792197
137Chronic otitis media (HP:0000389)1.95671719
138Chorioretinal atrophy (HP:0000533)1.95379738
139Proximal tubulopathy (HP:0000114)1.94253743
140Vaginal atresia (HP:0000148)1.94152464
141Abnormal gallbladder morphology (HP:0012437)1.93979563
142Bronchitis (HP:0012387)1.93938331
143Sensorimotor neuropathy (HP:0007141)1.93820545
144Generalized aminoaciduria (HP:0002909)1.93657278
145Thrombophlebitis (HP:0004418)1.93246293
146Alveolar cell carcinoma (HP:0006519)1.92289851
147Abnormal biliary tract morphology (HP:0012440)1.90302520
148Anencephaly (HP:0002323)1.88827855
149Abnormality of the nasal mucosa (HP:0000433)1.88762675
150Esophageal varix (HP:0002040)1.87640814
151Gingival bleeding (HP:0000225)1.86974117
152Hyperglycemia (HP:0003074)1.85265497
153Hyperkalemia (HP:0002153)1.84790363
154Menorrhagia (HP:0000132)1.84138597
155Brushfield spots (HP:0001088)1.83666181
156Hypokalemia (HP:0002900)1.83528314
157Hypochromic anemia (HP:0001931)1.82653424
158Abnormality of midbrain morphology (HP:0002418)1.82581037
159Molar tooth sign on MRI (HP:0002419)1.82581037
160Neoplasm of the tracheobronchial system (HP:0100552)1.81281919
161Vomiting (HP:0002013)1.80697068
162Postaxial hand polydactyly (HP:0001162)1.80697050
163Mitral stenosis (HP:0001718)1.80634684
164Elevated hepatic transaminases (HP:0002910)1.80416556
165Abnormality of potassium homeostasis (HP:0011042)1.80373602
166Recurrent sinusitis (HP:0011108)1.78110998
167Abolished electroretinogram (ERG) (HP:0000550)1.76614743
168Dyskinesia (HP:0100660)1.76492469
169Median cleft lip (HP:0000161)1.75926363
170Hyperphosphaturia (HP:0003109)1.73814698
171Potter facies (HP:0002009)1.71576311
172Facial shape deformation (HP:0011334)1.71576311
173Widely patent fontanelles and sutures (HP:0004492)1.69938077
174Male infertility (HP:0003251)1.67742488
175Poor coordination (HP:0002370)1.65996300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.83336799
2ACVR1B4.10527950
3MAPK153.74508972
4ERN13.14100488
5TAOK32.87354220
6SIK12.69642526
7INSRR2.65544201
8FGFR42.58905045
9PDK42.58897560
10PDK32.58897560
11LMTK22.57147436
12WNK32.53137371
13MST42.45034843
14STK392.25872808
15ERBB42.25134368
16DAPK22.25060227
17BMPR1B2.18296770
18FRK2.18007455
19OXSR12.12350194
20FLT32.04476092
21RIPK11.96434061
22MAP3K31.91654928
23MAPKAPK31.88706644
24PIK3CA1.85901665
25DYRK1B1.84567402
26STK38L1.77542671
27CASK1.69818149
28BCR1.68975660
29TIE11.62859984
30EEF2K1.57682346
31LATS11.54312625
32CAMK2G1.50756057
33MST1R1.50433573
34EPHA31.45700520
35NUAK11.45575604
36MAPK111.41115337
37ADRBK21.39173790
38PDK21.38234596
39MAPK131.36416715
40BRSK21.33911251
41PIK3CG1.33759278
42PTK61.33169492
43EPHB21.32000508
44MAP4K21.28629812
45EPHA41.27871609
46PRKAA21.25407348
47WNK41.23206071
48TNIK1.22379873
49MAP2K41.19868601
50AKT31.18946177
51MAP3K21.17502833
52TRIB31.16332248
53PAK31.14731857
54EPHA21.12534257
55PRKG21.11855786
56PHKG21.11759852
57PHKG11.11759852
58NTRK31.11025930
59PRKCE1.10791673
60CDK61.08988771
61PKN21.08793972
62TYK21.08249894
63MAP3K71.07220373
64TBK11.00622485
65TGFBR10.98023001
66CAMK2D0.97690514
67BRD40.97663114
68MAPKAPK50.94243515
69ICK0.93680262
70NEK60.93277111
71MET0.89939637
72MUSK0.89375539
73GRK60.88837588
74CSNK1G10.88263123
75BRAF0.88090440
76YES10.86601301
77TEC0.84111280
78NTRK20.83978420
79PRKAA10.82659840
80PTK2B0.82220847
81CSNK1A1L0.81994055
82CDK40.80713640
83MAP3K40.78089334
84IRAK10.76228026
85MAP3K140.76012772
86CAMKK20.73438204
87ADRBK10.73179680
88JAK20.73087266
89CSNK1G20.72423858
90RPS6KB10.72003027
91DYRK30.70853969
92CDK90.70086492
93PASK0.69998479
94JAK10.67729605
95NLK0.67264109
96MAP3K100.67036330
97STK110.65712473
98CSNK1G30.65545600
99TXK0.63826440
100MAP2K20.62875413
101SGK2230.61902128
102SGK4940.61902128
103NEK90.61744376
104PINK10.60856824
105FER0.59698279
106PKN10.58683308
107MARK10.58681674
108GSK3A0.58472909
109CAMK2B0.58436671
110IKBKE0.58434981
111PNCK0.58359912
112HIPK20.58076476
113MAPK40.54953349
114MAP3K120.54512582
115BMPR20.54001539
116PRKACG0.53682837
117MKNK20.53225063
118PRKCZ0.53036949
119PRKCG0.52988470
120PRKACA0.52951483
121FGFR20.52881035
122ERBB30.52776808
123ERBB20.51817130
124PRKCA0.51346306
125WEE10.49938145
126ARAF0.49576609
127STK380.48541544
128GRK10.46215166
129PLK20.45713463
130STK30.45017639
131TLK10.43560820
132PRKCQ0.42750532
133SGK30.42329059
134STK240.42251526
135PRKG10.40504417
136EPHB10.40362761
137ROCK10.39691938
138TESK10.38977227
139IGF1R0.38372099
140FGFR10.37666197
141ITK0.36116909
142ABL20.36019403
143MAP2K30.35863625
144PRKD30.35340391
145CAMK2A0.35079462
146TNK20.34759828
147SGK20.34455984
148FGFR30.34364325
149SGK10.33595044
150MAP2K60.33267451
151ABL10.32948902
152TAOK10.32742537
153BTK0.32458759
154PDGFRB0.32165005
155DYRK1A0.32027729
156MAPK70.31747767
157CDK190.31681351
158MAP3K60.31413163
159CSK0.31176390
160CSNK1A10.31175278

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39819072
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31498677
3Nitrogen metabolism_Homo sapiens_hsa009103.13230535
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82168804
5Arginine biosynthesis_Homo sapiens_hsa002202.70019318
6Complement and coagulation cascades_Homo sapiens_hsa046102.61650466
7Tryptophan metabolism_Homo sapiens_hsa003802.60326186
8Fatty acid degradation_Homo sapiens_hsa000712.49034501
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39835168
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37062417
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34946174
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29405586
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29213120
14Histidine metabolism_Homo sapiens_hsa003402.28528718
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14654560
16Propanoate metabolism_Homo sapiens_hsa006402.10920490
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07112671
18Peroxisome_Homo sapiens_hsa041462.05821829
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05125084
20Chemical carcinogenesis_Homo sapiens_hsa052041.99745167
21Sulfur metabolism_Homo sapiens_hsa009201.92880156
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91219751
23PPAR signaling pathway_Homo sapiens_hsa033201.89005301
24Caffeine metabolism_Homo sapiens_hsa002321.88839212
25Butanoate metabolism_Homo sapiens_hsa006501.85602391
26Retinol metabolism_Homo sapiens_hsa008301.79839612
27beta-Alanine metabolism_Homo sapiens_hsa004101.78640443
28Olfactory transduction_Homo sapiens_hsa047401.75198477
29Bile secretion_Homo sapiens_hsa049761.73418571
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.72377496
31Selenocompound metabolism_Homo sapiens_hsa004501.66962162
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65787486
33Fatty acid metabolism_Homo sapiens_hsa012121.65517096
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.58360768
35Pyruvate metabolism_Homo sapiens_hsa006201.57712824
36ABC transporters_Homo sapiens_hsa020101.53629077
37Phenylalanine metabolism_Homo sapiens_hsa003601.50522350
38Staphylococcus aureus infection_Homo sapiens_hsa051501.47346499
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40113320
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39937122
41Tyrosine metabolism_Homo sapiens_hsa003501.35432527
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32938396
43Fat digestion and absorption_Homo sapiens_hsa049751.32338711
44Starch and sucrose metabolism_Homo sapiens_hsa005001.30424550
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.23274789
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21689822
47Phototransduction_Homo sapiens_hsa047441.16986865
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.16558219
49Renin-angiotensin system_Homo sapiens_hsa046141.10880422
50Folate biosynthesis_Homo sapiens_hsa007901.10568461
51Steroid biosynthesis_Homo sapiens_hsa001001.07542100
52Vitamin B6 metabolism_Homo sapiens_hsa007501.06206667
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01217207
54Fatty acid elongation_Homo sapiens_hsa000620.95900965
55Carbon metabolism_Homo sapiens_hsa012000.95020104
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93255226
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88710801
58Fatty acid biosynthesis_Homo sapiens_hsa000610.88382014
59Sulfur relay system_Homo sapiens_hsa041220.88320318
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87870769
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87688003
62Biosynthesis of amino acids_Homo sapiens_hsa012300.87375399
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86820970
64Protein digestion and absorption_Homo sapiens_hsa049740.86594198
65Arginine and proline metabolism_Homo sapiens_hsa003300.80882232
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78496138
67Dorso-ventral axis formation_Homo sapiens_hsa043200.76269267
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76212879
69Glycerolipid metabolism_Homo sapiens_hsa005610.75863725
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68864950
71Pancreatic secretion_Homo sapiens_hsa049720.64163201
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63129767
73Serotonergic synapse_Homo sapiens_hsa047260.62558617
74Glutathione metabolism_Homo sapiens_hsa004800.62273038
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60797129
76Nicotine addiction_Homo sapiens_hsa050330.59696774
77Linoleic acid metabolism_Homo sapiens_hsa005910.59100229
78Lysine degradation_Homo sapiens_hsa003100.58633121
79Regulation of autophagy_Homo sapiens_hsa041400.56378960
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51082098
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50327575
82Cocaine addiction_Homo sapiens_hsa050300.50122200
83Protein export_Homo sapiens_hsa030600.47458853
84Circadian rhythm_Homo sapiens_hsa047100.47201769
85Metabolic pathways_Homo sapiens_hsa011000.46657127
86Ovarian steroidogenesis_Homo sapiens_hsa049130.46170415
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45638163
88Pentose phosphate pathway_Homo sapiens_hsa000300.43345622
89Glucagon signaling pathway_Homo sapiens_hsa049220.41683292
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36021068
91Galactose metabolism_Homo sapiens_hsa000520.33208157
92One carbon pool by folate_Homo sapiens_hsa006700.31990433
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31007948
94Glutamatergic synapse_Homo sapiens_hsa047240.29398597
95Salivary secretion_Homo sapiens_hsa049700.29270743
96Insulin resistance_Homo sapiens_hsa049310.28358478
97Circadian entrainment_Homo sapiens_hsa047130.28126785
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.28091476
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.28080103
100Taste transduction_Homo sapiens_hsa047420.27166341
101Huntingtons disease_Homo sapiens_hsa050160.26521512
102Gastric acid secretion_Homo sapiens_hsa049710.25685013
103Renin secretion_Homo sapiens_hsa049240.25673490
104Prion diseases_Homo sapiens_hsa050200.24272416
105Long-term depression_Homo sapiens_hsa047300.22471344
106Morphine addiction_Homo sapiens_hsa050320.20402090
107GABAergic synapse_Homo sapiens_hsa047270.20082477
108Dopaminergic synapse_Homo sapiens_hsa047280.19878430
109Amphetamine addiction_Homo sapiens_hsa050310.17459431
110Arachidonic acid metabolism_Homo sapiens_hsa005900.14005871
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09911513
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09442697
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08136916
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08103523
115Fructose and mannose metabolism_Homo sapiens_hsa000510.06803940
116Thyroid hormone synthesis_Homo sapiens_hsa049180.03515505
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01244436
118Mineral absorption_Homo sapiens_hsa04978-0.1563411
119Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1258844
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1234598
121Bladder cancer_Homo sapiens_hsa05219-0.1110374
122Other glycan degradation_Homo sapiens_hsa00511-0.1067109
123Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1041996
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0927884
125Ether lipid metabolism_Homo sapiens_hsa00565-0.0803363
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0615063
127Insulin secretion_Homo sapiens_hsa04911-0.0397159
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0372404
129Insulin signaling pathway_Homo sapiens_hsa04910-0.0355254
130Sphingolipid metabolism_Homo sapiens_hsa00600-0.0351361
131AMPK signaling pathway_Homo sapiens_hsa04152-0.0105100

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »