GRAMD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.77251342
2polyketide metabolic process (GO:0030638)8.75047133
3doxorubicin metabolic process (GO:0044598)8.75047133
4daunorubicin metabolic process (GO:0044597)8.75047133
5cilium movement (GO:0003341)8.22636484
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.87495821
7motile cilium assembly (GO:0044458)7.46469938
8epithelial cilium movement (GO:0003351)7.44489772
9regulation of response to osmotic stress (GO:0047484)6.67613249
10axoneme assembly (GO:0035082)6.25723306
11somite rostral/caudal axis specification (GO:0032525)6.06973423
12vitamin transmembrane transport (GO:0035461)5.99470561
13maintenance of protein location in nucleus (GO:0051457)5.86308262
14notochord development (GO:0030903)5.71639531
15surfactant homeostasis (GO:0043129)5.66836612
16aminoglycoside antibiotic metabolic process (GO:0030647)5.43282816
17regulation of mammary gland epithelial cell proliferation (GO:0033599)5.41926011
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.40362490
19negative regulation of epidermis development (GO:0045683)5.29169896
20desmosome organization (GO:0002934)5.04974598
21primary alcohol catabolic process (GO:0034310)4.99659877
22thyroid hormone generation (GO:0006590)4.95729905
23hormone catabolic process (GO:0042447)4.84114432
24muscle organ morphogenesis (GO:0048644)4.79159808
25negative regulation of cell cycle G2/M phase transition (GO:1902750)4.73180493
26negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.71618707
27cornea development in camera-type eye (GO:0061303)4.60331586
28chemical homeostasis within a tissue (GO:0048875)4.60206094
29arachidonic acid secretion (GO:0050482)4.55731112
30icosanoid secretion (GO:0032309)4.55731112
31mitochondrion distribution (GO:0048311)4.55350606
32regulation of MHC class I biosynthetic process (GO:0045343)4.49190218
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.42417518
34bundle of His cell to Purkinje myocyte communication (GO:0086069)4.41251505
35regulation of cilium movement (GO:0003352)4.39403143
36branching involved in mammary gland duct morphogenesis (GO:0060444)4.38613537
37negative regulation of T cell differentiation in thymus (GO:0033085)4.36936641
38keratinocyte development (GO:0003334)4.35572339
39histone H4-K12 acetylation (GO:0043983)4.35082350
40hypotonic response (GO:0006971)4.28381254
41negative regulation of telomerase activity (GO:0051974)4.27230089
42histone H4-K5 acetylation (GO:0043981)4.23858534
43histone H4-K8 acetylation (GO:0043982)4.23858534
44regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.18183489
45regulation of nuclear cell cycle DNA replication (GO:0033262)4.15101999
46intestinal epithelial cell development (GO:0060576)4.11465600
47left/right pattern formation (GO:0060972)4.07281694
48intraciliary transport (GO:0042073)4.05620634
49fatty acid derivative transport (GO:1901571)4.00153244
50icosanoid transport (GO:0071715)4.00153244
51phenol-containing compound catabolic process (GO:0019336)3.97070556
52negative regulation of epidermal cell differentiation (GO:0045605)3.96813131
53regulation of telomere maintenance via telomerase (GO:0032210)3.95492330
54negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.92874108
55positive regulation of DNA-dependent DNA replication (GO:2000105)3.91020805
56rRNA transcription (GO:0009303)3.90873151
57thyroid hormone metabolic process (GO:0042403)3.90136823
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.88829675
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.88711731
60diterpenoid biosynthetic process (GO:0016102)3.83958884
61response to dietary excess (GO:0002021)3.83824598
62cilium organization (GO:0044782)3.79253937
63regulation of apoptotic process involved in morphogenesis (GO:1902337)3.76375993
64epoxygenase P450 pathway (GO:0019373)3.74113080
65multicellular organismal water homeostasis (GO:0050891)3.70398591
66protein localization to kinetochore (GO:0034501)3.69696424
67regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.69607975
68cilium assembly (GO:0042384)3.66709685
69regulation of rhodopsin mediated signaling pathway (GO:0022400)3.64115422
70cytidine deamination (GO:0009972)3.62797440
71cytidine metabolic process (GO:0046087)3.62797440
72cytidine catabolic process (GO:0006216)3.62797440
73estrogen biosynthetic process (GO:0006703)3.61082977
74left/right axis specification (GO:0070986)3.59949448
75maintenance of protein localization in organelle (GO:0072595)3.58604958
76bone trabecula formation (GO:0060346)3.57818187
77negative regulation of interleukin-2 production (GO:0032703)3.57274497
78vitamin A metabolic process (GO:0006776)3.57086710
79adaptation of signaling pathway (GO:0023058)3.55849653
80proline transport (GO:0015824)3.52450202
81microtubule bundle formation (GO:0001578)3.52025719
82primitive streak formation (GO:0090009)3.51283937
83rhodopsin mediated signaling pathway (GO:0016056)3.48676711
84glutathione derivative biosynthetic process (GO:1901687)3.46871130
85glutathione derivative metabolic process (GO:1901685)3.46871130
86regulation of hippo signaling (GO:0035330)3.45137015
87cell fate commitment involved in formation of primary germ layer (GO:0060795)3.44273732
88ethanol metabolic process (GO:0006067)3.44022506
89RNA localization (GO:0006403)3.43345267
90retinoic acid metabolic process (GO:0042573)3.39307982
91positive regulation of histone deacetylation (GO:0031065)3.39304203
92omega-hydroxylase P450 pathway (GO:0097267)3.38425373
93keratan sulfate catabolic process (GO:0042340)3.38350968
94quinone metabolic process (GO:1901661)3.37530639
95water homeostasis (GO:0030104)3.35405391
96rRNA methylation (GO:0031167)3.34710105
97heterochromatin organization (GO:0070828)3.31184916
98terpenoid biosynthetic process (GO:0016114)3.30173034
99regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.28997348
100nucleoside transmembrane transport (GO:1901642)3.26631395
101positive regulation of protein deacetylation (GO:0090312)3.25055744
102piRNA metabolic process (GO:0034587)3.24909569
103microtubule severing (GO:0051013)3.24506560
104lung epithelium development (GO:0060428)3.23290024
105interferon-gamma production (GO:0032609)3.21271207
106regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.18083264
107transepithelial transport (GO:0070633)3.12553824
108negative regulation of humoral immune response (GO:0002921)3.11548733
109histone H4-K16 acetylation (GO:0043984)3.11040519
110trophectodermal cell differentiation (GO:0001829)3.10261423
111establishment of apical/basal cell polarity (GO:0035089)3.09650332
112coenzyme catabolic process (GO:0009109)3.09214334
113cilium morphogenesis (GO:0060271)3.08868955
114regulation of microtubule-based movement (GO:0060632)3.06166317
115establishment of monopolar cell polarity (GO:0061162)3.05894949
116establishment or maintenance of monopolar cell polarity (GO:0061339)3.05894949
117glutathione biosynthetic process (GO:0006750)3.05527828
118carnitine metabolic process (GO:0009437)3.03550772
119cardiovascular system development (GO:0072358)3.02623340
120regulation of ruffle assembly (GO:1900027)3.00831218
121negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.00538397
122cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.00307017
123anterior/posterior axis specification (GO:0009948)3.00236672
124nonribosomal peptide biosynthetic process (GO:0019184)2.98596562
125mitotic sister chromatid segregation (GO:0000070)2.97256430
126intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.95447595
127tight junction assembly (GO:0070830)2.95326536
128L-ascorbic acid metabolic process (GO:0019852)2.95235495
129regulation of mitochondrial translation (GO:0070129)2.94848354
130vitamin transport (GO:0051180)2.94550317
131negative regulation of systemic arterial blood pressure (GO:0003085)2.92522344
132intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.91755137
133photoreceptor cell maintenance (GO:0045494)2.90605923
134multicellular organism reproduction (GO:0032504)2.90289751
135branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89085711
136establishment of endothelial barrier (GO:0061028)2.89078462
137cerebral cortex neuron differentiation (GO:0021895)2.87992723
138tachykinin receptor signaling pathway (GO:0007217)2.87787014
139negative regulation of potassium ion transmembrane transport (GO:1901380)2.86103627
140embryonic axis specification (GO:0000578)2.85926780
141O-glycan processing (GO:0016266)2.82966594
142sphingoid metabolic process (GO:0046519)2.82899506
143excretion (GO:0007588)2.82899190
144phototransduction, visible light (GO:0007603)2.81384057
145cell projection assembly (GO:0030031)2.81276320
146one-carbon compound transport (GO:0019755)2.80586542
147diol metabolic process (GO:0034311)2.80568897
148regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80267772
149L-fucose catabolic process (GO:0042355)2.79515372
150fucose catabolic process (GO:0019317)2.79515372
151L-fucose metabolic process (GO:0042354)2.79515372
152protein localization to cilium (GO:0061512)2.79311523
153positive regulation of digestive system process (GO:0060456)2.77718326
154cyclooxygenase pathway (GO:0019371)2.77306348
155negative regulation of telomere maintenance (GO:0032205)2.76816403
156ventricular system development (GO:0021591)2.76416935
157synaptic vesicle maturation (GO:0016188)2.76203462
158cartilage condensation (GO:0001502)2.75671494
159cell aggregation (GO:0098743)2.75671494
160rRNA modification (GO:0000154)2.75540426
161protein polyglutamylation (GO:0018095)2.75505562
162retinoic acid receptor signaling pathway (GO:0048384)2.75369070
163cellular component assembly involved in morphogenesis (GO:0010927)2.73061037
164regulation of water loss via skin (GO:0033561)2.73057964
165norepinephrine metabolic process (GO:0042415)2.72719279
166protein autoprocessing (GO:0016540)2.71822141
167behavioral response to nicotine (GO:0035095)2.68287488
168primary alcohol metabolic process (GO:0034308)2.63579711
169phenylpropanoid metabolic process (GO:0009698)2.63058455
170ubiquinone biosynthetic process (GO:0006744)2.62355604
171iron ion import (GO:0097286)2.62165973
172establishment of tissue polarity (GO:0007164)2.62046555
173establishment of planar polarity (GO:0001736)2.62046555
174amino-acid betaine metabolic process (GO:0006577)2.61096090
175glomerular epithelial cell development (GO:0072310)2.60742013
176nitric oxide biosynthetic process (GO:0006809)2.60195887
177sodium ion homeostasis (GO:0055078)2.56843878
178neurotransmitter catabolic process (GO:0042135)2.53918378
179nucleotide transmembrane transport (GO:1901679)2.52907618
180response to xenobiotic stimulus (GO:0009410)2.48888066
181negative regulation of complement activation (GO:0045916)2.47401169
182exogenous drug catabolic process (GO:0042738)2.47379412
183establishment of skin barrier (GO:0061436)2.46913502
184parturition (GO:0007567)2.45299028
185endocrine hormone secretion (GO:0060986)2.44743872
186rRNA catabolic process (GO:0016075)2.44357488
187benzene-containing compound metabolic process (GO:0042537)2.43922681
188trivalent inorganic anion homeostasis (GO:0072506)2.43550346
189phosphate ion homeostasis (GO:0055062)2.43550346
190axonemal dynein complex assembly (GO:0070286)10.0029018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.40487431
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.08772422
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.08772422
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.08772422
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31801884
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30147342
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.26398233
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.06983783
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.06773500
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94054963
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.67676147
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.60597508
13TCF3_18692474_ChIP-Seq_MESCs_Mouse2.52909686
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.49914960
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49116228
16VDR_22108803_ChIP-Seq_LS180_Human2.46832518
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.25810264
18ARNT_22903824_ChIP-Seq_MCF-7_Human2.21863968
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17875405
20NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.15667742
21* GATA4_25053715_ChIP-Seq_YYC3_Human2.11863585
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.11768867
23* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07697891
24CDX2_20551321_ChIP-Seq_CACO-2_Human2.03661375
25ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00587759
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90083697
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88002558
28NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.87005408
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81734629
30TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.78655620
31SOX2_20726797_ChIP-Seq_SW620_Human1.74647577
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73537646
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73352580
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.72000269
35ZNF274_21170338_ChIP-Seq_K562_Hela1.70180088
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69133201
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67216153
38* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66476180
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.65826703
40* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.63261504
41* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63111499
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.61408212
43KDM2B_26808549_Chip-Seq_K562_Human1.60653346
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60086541
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.58794341
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58618416
47NANOG_18692474_ChIP-Seq_MESCs_Mouse1.56540916
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50081993
49NANOG_18692474_ChIP-Seq_MEFs_Mouse1.47919815
50POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46649150
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45738163
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.44002060
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44002060
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42493826
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.42470858
56DROSHA_22980978_ChIP-Seq_HELA_Human1.41233113
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40944020
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40625437
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39375288
60ZNF263_19887448_ChIP-Seq_K562_Human1.37655833
61ELF5_23300383_ChIP-Seq_T47D_Human1.36419724
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35777964
63E2F1_17053090_ChIP-ChIP_MCF-7_Human1.34409145
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.34124381
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31934565
66TCF4_22108803_ChIP-Seq_LS180_Human1.27912340
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26255595
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.26240092
69AR_20517297_ChIP-Seq_VCAP_Human1.25574464
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24928650
71NANOG_16518401_ChIP-PET_MESCs_Mouse1.24048990
72* TP63_23658742_ChIP-Seq_EP156T_Human1.23798388
73ER_23166858_ChIP-Seq_MCF-7_Human1.21724865
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.21703526
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20786253
76* SMC4_20622854_ChIP-Seq_HELA_Human1.20618007
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20299217
78IRF1_19129219_ChIP-ChIP_H3396_Human1.19600887
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.19110467
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18292706
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17810718
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17361481
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.17353203
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16477981
85POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16441027
86FOXA1_25552417_ChIP-Seq_VCAP_Human1.16278260
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15351134
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.12393384
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11461282
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11452964
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11347661
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11107008
93GATA1_22025678_ChIP-Seq_K562_Human1.09534948
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09520463
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09076191
96KLF5_25053715_ChIP-Seq_YYC3_Human1.07837017
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07379987
98ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06544286
99ETV1_20927104_ChIP-Seq_GIST48_Human1.05565319
100TP53_22127205_ChIP-Seq_IMR90_Human1.05159175
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.04317071
102FOXH1_21741376_ChIP-Seq_ESCs_Human1.03984590
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03946747
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02941835
105* GATA6_25053715_ChIP-Seq_YYC3_Human1.01911653
106SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01355023
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01303154
108TP53_20018659_ChIP-ChIP_R1E_Mouse1.01017898
109TP53_16413492_ChIP-PET_HCT116_Human1.00397897
110AHR_22903824_ChIP-Seq_MCF-7_Human0.99739037
111ERA_21632823_ChIP-Seq_H3396_Human0.99684307
112TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99658113
113TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99584516
114RBPJ_21746931_ChIP-Seq_IB4_Human0.98707505
115LXR_22292898_ChIP-Seq_THP-1_Human0.98550976
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98014364
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97971180
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97814048
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97682857
120PHF8_20622853_ChIP-Seq_HELA_Human0.97585344
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.97131624
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97128266
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97128266
124NCOR_22424771_ChIP-Seq_293T_Human0.96828680
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96230837
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.96025798
127NANOG_20526341_ChIP-Seq_ESCs_Human0.95956434
128CDX2_22108803_ChIP-Seq_LS180_Human0.95462896
129RUNX2_22187159_ChIP-Seq_PCA_Human0.95427716
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95203982
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94945413
132RNF2_27304074_Chip-Seq_NSC_Mouse0.94819527
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92410830
134STAT3_23295773_ChIP-Seq_U87_Human0.91765223
135PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91032961
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90981575
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90868395
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.90726562
139SOX2_19829295_ChIP-Seq_ESCs_Human0.90456203
140NANOG_19829295_ChIP-Seq_ESCs_Human0.90456203
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90441178
142NCOR1_26117541_ChIP-Seq_K562_Human0.89328163
143STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88159596
144SMAD4_21799915_ChIP-Seq_A2780_Human0.88078447
145TCF4_23295773_ChIP-Seq_U87_Human0.87968905
146TAF15_26573619_Chip-Seq_HEK293_Human0.87756007
147KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87709257
148OCT4_20526341_ChIP-Seq_ESCs_Human0.87157623
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.86649007
150* MYC_19829295_ChIP-Seq_ESCs_Human0.86339805
151TAF2_19829295_ChIP-Seq_ESCs_Human0.85650406
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84989740
153SALL1_21062744_ChIP-ChIP_HESCs_Human0.84562076
154CEBPB_22108803_ChIP-Seq_LS180_Human0.84364677
155CBP_20019798_ChIP-Seq_JUKART_Human0.84316787
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84316787
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.84128425
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84116762
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84105236
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84012887
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83648677
162GATA3_24758297_ChIP-Seq_MCF-7_Human0.83500885
163BCAT_22108803_ChIP-Seq_LS180_Human0.83346123
164CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82549157
165GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81644836
166* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81540742
167* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81336441
168* TP63_22573176_ChIP-Seq_HFKS_Human0.80483768
169SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79033338
170TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78170542
171* ELK3_25401928_ChIP-Seq_HUVEC_Human0.77538696
172P68_20966046_ChIP-Seq_HELA_Human0.77141279
173CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76831977
174RNF2_27304074_Chip-Seq_ESCs_Mouse0.75063936
175P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74220234
176CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73764946
177* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73334635
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.72702939
179BMI1_23680149_ChIP-Seq_NPCS_Mouse0.72614933
180TCF7_22412390_ChIP-Seq_EML_Mouse0.72041599
181HOXB7_26014856_ChIP-Seq_BT474_Human0.71104904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.12934021
2MP0002254_reproductive_system_inflammat4.09300239
3MP0004264_abnormal_extraembryonic_tissu4.00875157
4MP0008875_abnormal_xenobiotic_pharmacok3.90278955
5MP0004782_abnormal_surfactant_physiolog3.55995057
6MP0010234_abnormal_vibrissa_follicle3.54162877
7MP0003890_abnormal_embryonic-extraembry3.35081724
8MP0009780_abnormal_chondrocyte_physiolo3.33232000
9MP0003878_abnormal_ear_physiology3.28000929
10MP0005377_hearing/vestibular/ear_phenot3.28000929
11MP0006292_abnormal_olfactory_placode3.26537178
12MP0004858_abnormal_nervous_system3.25677160
13MP0005083_abnormal_biliary_tract3.18863817
14MP0002876_abnormal_thyroid_physiology2.95767087
15MP0005257_abnormal_intraocular_pressure2.93738721
16MP0004019_abnormal_vitamin_homeostasis2.91740733
17MP0005394_taste/olfaction_phenotype2.74843904
18MP0005499_abnormal_olfactory_system2.74843904
19MP0002332_abnormal_exercise_endurance2.63427377
20MP0000566_synostosis2.57397554
21MP0000678_abnormal_parathyroid_gland2.47017835
22MP0003122_maternal_imprinting2.46491475
23MP0005551_abnormal_eye_electrophysiolog2.29805199
24MP0000427_abnormal_hair_cycle2.29119074
25MP0003705_abnormal_hypodermis_morpholog2.28047583
26MP0002653_abnormal_ependyma_morphology2.24528748
27MP0005075_abnormal_melanosome_morpholog2.16763710
28MP0003950_abnormal_plasma_membrane2.08613225
29MP0005253_abnormal_eye_physiology2.04078499
30MP0000762_abnormal_tongue_morphology2.01123919
31MP0000579_abnormal_nail_morphology2.00123218
32MP0008961_abnormal_basal_metabolism1.94026639
33MP0000647_abnormal_sebaceous_gland1.87893549
34MP0005646_abnormal_pituitary_gland1.82261558
35MP0003121_genomic_imprinting1.82185140
36MP0010352_gastrointestinal_tract_polyps1.77255460
37MP0002277_abnormal_respiratory_mucosa1.76217951
38MP0003123_paternal_imprinting1.74828704
39MP0002160_abnormal_reproductive_system1.71659345
40MP0001958_emphysema1.61123028
41MP0010368_abnormal_lymphatic_system1.59745733
42MP0001849_ear_inflammation1.55454439
43MP0003718_maternal_effect1.50996332
44MP0003119_abnormal_digestive_system1.50251043
45MP0005085_abnormal_gallbladder_physiolo1.50104540
46MP0003183_abnormal_peptide_metabolism1.49580872
47MP0010030_abnormal_orbit_morphology1.46381316
48MP0002233_abnormal_nose_morphology1.44345187
49MP0005391_vision/eye_phenotype1.43904384
50MP0002127_abnormal_cardiovascular_syste1.43539343
51MP0004147_increased_porphyrin_level1.41588393
52MP0006072_abnormal_retinal_apoptosis1.40704523
53MP0003283_abnormal_digestive_organ1.40045182
54MP0005365_abnormal_bile_salt1.37600201
55MP0003938_abnormal_ear_development1.36972820
56MP0002638_abnormal_pupillary_reflex1.35869023
57MP0003195_calcinosis1.35336779
58MP0004272_abnormal_basement_membrane1.34462933
59MP0001765_abnormal_ion_homeostasis1.33130385
60MP0005389_reproductive_system_phenotype1.32325277
61MP0000383_abnormal_hair_follicle1.25550774
62MP0000377_abnormal_hair_follicle1.25169234
63MP0002932_abnormal_joint_morphology1.24758125
64MP0001984_abnormal_olfaction1.24277857
65MP0008004_abnormal_stomach_pH1.23185749
66MP0005248_abnormal_Harderian_gland1.22530028
67MP0005195_abnormal_posterior_eye1.20763244
68MP0001756_abnormal_urination1.20365162
69MP0000049_abnormal_middle_ear1.20349638
70MP0000631_abnormal_neuroendocrine_gland1.19319749
71MP0000163_abnormal_cartilage_morphology1.18332458
72MP0002909_abnormal_adrenal_gland1.17855595
73MP0001293_anophthalmia1.17738218
74MP0002132_abnormal_respiratory_system1.16493722
75MP0002938_white_spotting1.14158770
76MP0003935_abnormal_craniofacial_develop1.13502148
77MP0000432_abnormal_head_morphology1.13186057
78MP0003755_abnormal_palate_morphology1.12955028
79MP0005508_abnormal_skeleton_morphology1.12694992
80MP0009643_abnormal_urine_homeostasis1.11704050
81MP0008995_early_reproductive_senescence1.11268034
82MP0004043_abnormal_pH_regulation1.10880661
83MP0005380_embryogenesis_phenotype1.10719589
84MP0001672_abnormal_embryogenesis/_devel1.10719589
85MP0008872_abnormal_physiological_respon1.10524750
86MP0005332_abnormal_amino_acid1.09634545
87MP0003787_abnormal_imprinting1.08696038
88MP0003879_abnormal_hair_cell1.08599910
89MP0009379_abnormal_foot_pigmentation1.08444168
90MP0009250_abnormal_appendicular_skeleto1.08243382
91MP0006035_abnormal_mitochondrial_morpho1.07030400
92MP0001324_abnormal_eye_pigmentation1.06859645
93MP0005395_other_phenotype1.06858854
94MP0005636_abnormal_mineral_homeostasis1.06821068
95MP0004957_abnormal_blastocyst_morpholog1.06325442
96MP0002088_abnormal_embryonic_growth/wei1.05241812
97MP0001346_abnormal_lacrimal_gland1.05005783
98MP0003984_embryonic_growth_retardation1.04871711
99MP0004883_abnormal_blood_vessel1.03717814
100MP0001485_abnormal_pinna_reflex1.02766967
101MP0010678_abnormal_skin_adnexa1.02077248
102MP0003936_abnormal_reproductive_system1.00455137
103MP0001881_abnormal_mammary_gland0.99879280
104MP0002092_abnormal_eye_morphology0.99580929
105MP0000428_abnormal_craniofacial_morphol0.99384818
106MP0002114_abnormal_axial_skeleton0.99199341
107MP0000003_abnormal_adipose_tissue0.98147960
108MP0002116_abnormal_craniofacial_bone0.98068691
109MP0001216_abnormal_epidermal_layer0.96831744
110MP0003806_abnormal_nucleotide_metabolis0.96090903
111MP0006276_abnormal_autonomic_nervous0.93881994
112MP0010771_integument_phenotype0.92654747
113MP0002796_impaired_skin_barrier0.91094434
114MP0000627_abnormal_mammary_gland0.90870354
115MP0002168_other_aberrant_phenotype0.90274267
116MP0003786_premature_aging0.90087083
117MP0002925_abnormal_cardiovascular_devel0.89949165
118MP0001270_distended_abdomen0.88533059
119MP0002752_abnormal_somatic_nervous0.88138883
120MP0005410_abnormal_fertilization0.87594895
121MP0001177_atelectasis0.87488717
122MP0002098_abnormal_vibrissa_morphology0.87189374
123MP0001664_abnormal_digestion0.86079120
124MP0003941_abnormal_skin_development0.86006956
125MP0001666_abnormal_nutrient_absorption0.85239047
126MP0005408_hypopigmentation0.82954137
127MP0001968_abnormal_touch/_nociception0.82900782
128MP0005501_abnormal_skin_physiology0.82486353
129MP0002086_abnormal_extraembryonic_tissu0.82127210
130MP0005623_abnormal_meninges_morphology0.81954696
131MP0010386_abnormal_urinary_bladder0.80803904
132MP0008789_abnormal_olfactory_epithelium0.80552470
133MP0002295_abnormal_pulmonary_circulatio0.80343961
134MP0009046_muscle_twitch0.79179552
135MP0002136_abnormal_kidney_physiology0.78966401
136MP0000639_abnormal_adrenal_gland0.78774500
137MP0005023_abnormal_wound_healing0.77976651
138MP0001286_abnormal_eye_development0.77703240
139MP0002085_abnormal_embryonic_tissue0.77352212
140MP0001919_abnormal_reproductive_system0.76880813
141MP0001542_abnormal_bone_strength0.76818906
142MP0003136_yellow_coat_color0.76809848
143MP0002109_abnormal_limb_morphology0.76604934
144MP0000467_abnormal_esophagus_morphology0.76069904
145MP0002102_abnormal_ear_morphology0.74757303
146MP0008057_abnormal_DNA_replication0.73386539
147MP0004085_abnormal_heartbeat0.73015191
148MP0002736_abnormal_nociception_after0.72132367
149MP0005197_abnormal_uvea_morphology0.71973168
150MP0002234_abnormal_pharynx_morphology0.71779023
151MP0000350_abnormal_cell_proliferation0.71768807
152MP0002090_abnormal_vision0.71133140
153MP0004197_abnormal_fetal_growth/weight/0.70489272
154MP0000681_abnormal_thyroid_gland0.69697531
155MP0005388_respiratory_system_phenotype0.69381604
156MP0002133_abnormal_respiratory_system0.69381604
157MP0003137_abnormal_impulse_conducting0.69145227
158MP0000613_abnormal_salivary_gland0.68581823
159MP0002735_abnormal_chemical_nociception0.68259415
160MP0002751_abnormal_autonomic_nervous0.67126676
161MP0002084_abnormal_developmental_patter0.66946790
162MP0001943_abnormal_respiration0.66857170
163MP0003937_abnormal_limbs/digits/tail_de0.66613357
164MP0005164_abnormal_response_to0.66304631
165MP0004133_heterotaxia0.66197867
166MP0005379_endocrine/exocrine_gland_phen0.66014578
167MP0002272_abnormal_nervous_system0.65201372
168MP0001348_abnormal_lacrimal_gland0.65075595
169MP0002733_abnormal_thermal_nociception0.64586043
170MP0003638_abnormal_response/metabolism_0.63069463
171MP0001502_abnormal_circadian_rhythm0.61651680
172MP0008775_abnormal_heart_ventricle0.61607826
173MP0001970_abnormal_pain_threshold0.61026430
174MP0003252_abnormal_bile_duct0.59937844
175MP0002557_abnormal_social/conspecific_i0.59784312

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.85104810
2Abnormal respiratory motile cilium morphology (HP:0005938)7.50191387
3Abnormal respiratory epithelium morphology (HP:0012253)7.50191387
4Absent/shortened dynein arms (HP:0200106)7.47348938
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.47348938
6Abnormal ciliary motility (HP:0012262)7.16057268
7Abnormal respiratory motile cilium physiology (HP:0012261)7.11120161
8Rhinitis (HP:0012384)6.52177982
9Bilateral microphthalmos (HP:0007633)5.88145680
10Hepatoblastoma (HP:0002884)4.93690508
11Bronchiectasis (HP:0002110)4.73271491
12Abnormality of the lower motor neuron (HP:0002366)4.42806108
13Hypochromic microcytic anemia (HP:0004840)4.09616076
14Irregular epiphyses (HP:0010582)3.93583851
15Vitreoretinal degeneration (HP:0000655)3.62957072
16Pendular nystagmus (HP:0012043)3.60594226
17Pancreatic fibrosis (HP:0100732)3.57921602
18Partial duplication of thumb phalanx (HP:0009944)3.51470386
19Congenital stationary night blindness (HP:0007642)3.49866612
20True hermaphroditism (HP:0010459)3.43690055
21Pancreatic cysts (HP:0001737)3.38801681
22Nasal polyposis (HP:0100582)3.38219436
23Nephronophthisis (HP:0000090)3.37460523
24Rib fusion (HP:0000902)3.37436222
25Epiphyseal dysplasia (HP:0002656)3.31598914
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.23483697
27Hypoplasia of the fovea (HP:0007750)3.23483697
28Flat capital femoral epiphysis (HP:0003370)3.19546282
29Multiple enchondromatosis (HP:0005701)3.19235290
30Tubular atrophy (HP:0000092)3.18621967
31Abnormality of midbrain morphology (HP:0002418)3.16409988
32Molar tooth sign on MRI (HP:0002419)3.16409988
33Abnormality of the renal medulla (HP:0100957)3.13755977
34Abnormality of the pubic bones (HP:0003172)3.07859481
35Concave nail (HP:0001598)3.03980704
36Interstitial pulmonary disease (HP:0006530)3.02348945
37Partial duplication of the phalanx of hand (HP:0009999)2.99266208
38Metaphyseal cupping (HP:0003021)2.96409649
39Decreased circulating renin level (HP:0003351)2.95622469
40Bony spicule pigmentary retinopathy (HP:0007737)2.93254940
41Abnormal cartilage morphology (HP:0002763)2.91057638
42Abnormality of the fovea (HP:0000493)2.85565593
43Dyschromatopsia (HP:0007641)2.83839886
44Bronchitis (HP:0012387)2.80084902
45Cystic liver disease (HP:0006706)2.78276340
46Abnormality of the renal cortex (HP:0011035)2.76465853
47Abnormality of renin-angiotensin system (HP:0000847)2.71570046
48Ependymoma (HP:0002888)2.70656299
49Hyperactive renin-angiotensin system (HP:0000841)2.66338521
50Amelogenesis imperfecta (HP:0000705)2.64299094
51Chronic sinusitis (HP:0011109)2.62179542
52Flat acetabular roof (HP:0003180)2.59055782
53Ulnar bowing (HP:0003031)2.56099809
54Hand muscle atrophy (HP:0009130)2.53810174
55Hyperaldosteronism (HP:0000859)2.53439848
56Infertility (HP:0000789)2.53098273
57Tubulointerstitial fibrosis (HP:0005576)2.51951508
58Occipital encephalocele (HP:0002085)2.51428735
59Small epiphyses (HP:0010585)2.50954180
60Fused cervical vertebrae (HP:0002949)2.47269749
61Medial flaring of the eyebrow (HP:0010747)2.45770362
62Nephroblastoma (Wilms tumor) (HP:0002667)2.45506866
63Horizontal nystagmus (HP:0000666)2.44396445
64Abnormality of the salivary glands (HP:0010286)2.43760476
65Chronic bronchitis (HP:0004469)2.43759259
66Rectal fistula (HP:0100590)2.42922147
67Rectovaginal fistula (HP:0000143)2.42922147
68Shawl scrotum (HP:0000049)2.39926643
69Scotoma (HP:0000575)2.38023299
70Abnormality of the pulmonary veins (HP:0011718)2.37463051
71Genu varum (HP:0002970)2.34337704
72Hypoplastic ischia (HP:0003175)2.34266129
73Bifid tongue (HP:0010297)2.33612910
74Mildly elevated creatine phosphokinase (HP:0008180)2.33599922
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.31965471
76Chorioretinal atrophy (HP:0000533)2.30608831
77Polydipsia (HP:0001959)2.29059376
78Abnormal drinking behavior (HP:0030082)2.29059376
79Pili torti (HP:0003777)2.28054778
80Short humerus (HP:0005792)2.27852984
81Abnormality of the distal phalanx of the thumb (HP:0009617)2.27471130
82Delayed epiphyseal ossification (HP:0002663)2.24696654
83Embryonal renal neoplasm (HP:0011794)2.24537885
84Amyotrophic lateral sclerosis (HP:0007354)2.24038513
85Nasolacrimal duct obstruction (HP:0000579)2.23992612
86Intestinal fistula (HP:0100819)2.22394076
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21214124
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.21159637
89Neonatal short-limb short stature (HP:0008921)2.20620800
90Neoplasm of striated muscle (HP:0009728)2.20392473
91Congenital hepatic fibrosis (HP:0002612)2.20280725
92Abnormality of the musculature of the hand (HP:0001421)2.19886323
93Aplasia/Hypoplasia of the scapulae (HP:0006713)2.18642903
94Hypoplastic scapulae (HP:0000882)2.18642903
95Vaginal fistula (HP:0004320)2.17942301
96Short middle phalanx of finger (HP:0005819)2.16925434
97Hypokalemic alkalosis (HP:0001949)2.16191139
98Glossoptosis (HP:0000162)2.15341484
99Aplasia/hypoplasia of the humerus (HP:0006507)2.15137756
100Tubulointerstitial nephritis (HP:0001970)2.14503035
101Right ventricular cardiomyopathy (HP:0011663)2.14082274
102Abnormality of the dental root (HP:0006486)2.13143023
103Taurodontia (HP:0000679)2.13143023
104Abnormality of permanent molar morphology (HP:0011071)2.13143023
105Male infertility (HP:0003251)2.12638320
106Cone-rod dystrophy (HP:0000548)2.12245634
107Median cleft lip (HP:0000161)2.12243352
108Abnormal rod and cone electroretinograms (HP:0008323)2.11943442
109Renal salt wasting (HP:0000127)2.10889958
110Anomalous pulmonary venous return (HP:0010772)2.09512647
111Furrowed tongue (HP:0000221)2.09278049
112Periauricular skin pits (HP:0100277)2.06972520
113Preauricular pit (HP:0004467)2.06972520
114Postaxial foot polydactyly (HP:0001830)2.06614461
115Abnormality of dental color (HP:0011073)2.06283828
116Testicular atrophy (HP:0000029)2.05613457
117Abnormality of the astrocytes (HP:0100707)2.03440526
118Astrocytoma (HP:0009592)2.03440526
119Mild short stature (HP:0003502)2.02394273
120Mesomelia (HP:0003027)2.01054710
121Distal upper limb amyotrophy (HP:0007149)2.00905671
122Upper limb amyotrophy (HP:0009129)2.00905671
123Tubulointerstitial abnormality (HP:0001969)2.00774005
124Congenital primary aphakia (HP:0007707)2.00187982
125Gait imbalance (HP:0002141)1.99514076
126Abnormality of the ischium (HP:0003174)1.99214011
127Abnormality of the dental pulp (HP:0006479)1.98921856
128Recurrent sinusitis (HP:0011108)1.98410877
129Hyperinsulinemic hypoglycemia (HP:0000825)1.96362948
130Abnormality of renal excretion (HP:0011036)1.95909800
131Sensory axonal neuropathy (HP:0003390)1.93515506
132Woolly hair (HP:0002224)1.93066604
133Aplasia/Hypoplasia of the macula (HP:0008059)1.92226876
134Pigmentary retinal degeneration (HP:0001146)1.92082849
135Chronic hepatic failure (HP:0100626)1.92067516
136Generalized hypotonia (HP:0001290)1.90810745
137Asplenia (HP:0001746)1.90714951
138Nephrogenic diabetes insipidus (HP:0009806)1.90170428
139Abnormality of molar (HP:0011077)1.90122459
140Abnormality of molar morphology (HP:0011070)1.90122459
141Hyperventilation (HP:0002883)1.89851403
142Rhabdomyosarcoma (HP:0002859)1.89003083
143Abnormality of femoral epiphyses (HP:0006499)1.88438409
144Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.88438409
145Recurrent otitis media (HP:0000403)1.87831238
146Gout (HP:0001997)1.87322243
147Cupped ribs (HP:0000887)1.87248241
148Hypoplastic labia majora (HP:0000059)1.86883257
149Increased connective tissue (HP:0009025)1.86645627
150Polyuria (HP:0000103)1.86598736
151Flattened epiphyses (HP:0003071)1.86238109
152Short 5th finger (HP:0009237)1.85062368
153Tachypnea (HP:0002789)1.84664527
154Decreased central vision (HP:0007663)1.84313844
155Vertebral clefting (HP:0008428)1.84100937
156Abnormality of the nasal mucosa (HP:0000433)1.83111718
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.83044793
158Vascular calcification (HP:0004934)1.82802206
159Osteoarthritis (HP:0002758)1.81971382
160Male pseudohermaphroditism (HP:0000037)1.81709026
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81390040
162Malnutrition (HP:0004395)1.80299290
163Large for gestational age (HP:0001520)1.80051376
164Abnormal lung lobation (HP:0002101)1.79424908
165Alkalosis (HP:0001948)1.79353140
166Fragile nails (HP:0001808)1.79203144
167Abnormality of the epiphysis of the femoral head (HP:0010574)1.78422706
168Anencephaly (HP:0002323)1.76896572
169Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76079194
170Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.76064071
171Hypomagnesemia (HP:0002917)1.75615391
172Arthropathy (HP:0003040)1.75115628
173Popliteal pterygium (HP:0009756)1.71659878
174Hyperglycinuria (HP:0003108)1.70959460
175Abnormal hair laboratory examination (HP:0003328)1.70526792
176Chronic otitis media (HP:0000389)1.69833428
177Sclerocornea (HP:0000647)1.69251096
178Genital tract atresia (HP:0001827)1.68403989
179Stage 5 chronic kidney disease (HP:0003774)1.67848415
180Vaginal atresia (HP:0000148)1.67462275
181Abnormality of macular pigmentation (HP:0008002)1.67094533
182Alveolar cell carcinoma (HP:0006519)1.66021019
183Abnormality of magnesium homeostasis (HP:0004921)1.65911047
184Abnormality of the renal collecting system (HP:0004742)1.65538702
185Abnormality of the labia majora (HP:0012881)1.64849536
186Type II lissencephaly (HP:0007260)1.62294507
187Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61063605
188Abnormality of chloride homeostasis (HP:0011422)1.59408845
189Lip pit (HP:0100267)1.57287025
190Congenital, generalized hypertrichosis (HP:0004540)1.56732452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.20029769
2GRK55.51186496
3GRK14.64274145
4MAPK154.32817728
5ERN14.03264521
6GRK63.72396382
7TGFBR23.02551665
8STK393.00840658
9WNK42.94638561
10FRK2.83117172
11OXSR12.74341445
12TYRO32.62878157
13ADRBK22.44097451
14GRK72.35784824
15MAPK72.32397162
16CSF1R2.23260120
17STK102.15472023
18MAP3K22.01272299
19MATK1.96242442
20WNK11.95414996
21EPHA21.91810695
22PRKG21.90018703
23MOS1.83228333
24TTK1.80537731
25MAPKAPK31.71857986
26NTRK11.68765175
27BMPR1B1.67382746
28AKT31.62958573
29DDR21.58897177
30MARK21.41204723
31STK161.38618731
32PAK41.33995271
33WNK31.33649820
34ADRBK11.31763057
35CAMK41.26471216
36FGFR31.24500758
37MAP3K91.22274440
38MAP3K121.17991549
39RPS6KB21.13752824
40HIPK21.11122288
41DAPK21.07929292
42MAP2K41.04798307
43PRKCE0.99665587
44TLK10.96668529
45EIF2AK10.95518828
46RIPK10.92542634
47CDK70.91376992
48EPHB10.90284305
49TAOK10.87823533
50TESK10.86120449
51NEK60.83980220
52LATS20.83214645
53STK240.82398495
54CSK0.81525825
55EPHA30.81294240
56CAMKK20.79307270
57MAPK120.79085853
58BCR0.79036334
59PTK2B0.77005063
60INSRR0.75918375
61BRSK20.75089435
62MAP3K30.74614721
63PTK20.73717616
64ALK0.72544763
65MAP3K70.70245155
66ICK0.69566590
67MAPK130.68701188
68MST40.65921902
69ACVR1B0.65138033
70MAP2K60.64531876
71ABL20.62746565
72TGFBR10.60556046
73FER0.60088176
74FGFR20.59154541
75MYLK0.58238815
76BCKDK0.57966987
77CAMK2G0.56979351
78CHEK20.54532827
79STK30.54376689
80TIE10.52854655
81MAP2K70.52495977
82FLT30.51476214
83AKT20.50404426
84EPHB20.50318183
85PRKCI0.50285524
86PRKD20.50093032
87PIK3CA0.48804854
88PRKD30.48054160
89PINK10.47447376
90MAPKAPK50.46395544
91MAP3K40.45753718
92BLK0.45696491
93ERBB20.45599989
94EPHA40.45154806
95DYRK1A0.44654633
96PDPK10.44344460
97MAP4K20.43544947
98IGF1R0.41725126
99PRKCZ0.41563940
100STK380.40721144
101PLK10.40518463
102DAPK10.40328440
103PRKCA0.39888367
104CHEK10.39272762
105ZAK0.38855193
106PDGFRA0.38690381
107YES10.38594197
108CAMKK10.37899206
109STK38L0.36573748
110LRRK20.36233762
111MTOR0.35988651
112TNIK0.35576507
113EIF2AK30.35082963
114MET0.34217627
115EIF2AK20.34059125
116PAK60.33982049
117PTK60.33901419
118CSNK1A1L0.32295222
119GSK3A0.31954670
120MAP3K100.31929486
121CSNK1A10.31784014
122CHUK0.31706186
123PRKACG0.31102245
124MAPK100.31005358
125CAMK2A0.30984160
126PRKCH0.30505825
127BMX0.29749834
128NME10.29196040
129TRIB30.28873793
130PRKCD0.28739450
131BMPR20.28573669
132PDGFRB0.28403201
133NEK20.27774485
134CAMK2D0.26614696
135AURKA0.26328010
136INSR0.25709991
137PRKAA20.24327711
138MST1R0.24291045
139DAPK30.24273898
140CSNK1E0.24032816
141PRKCQ0.23765609
142PRKCG0.23243206
143PAK30.23230579
144VRK20.23032426
145CAMK2B0.22647252
146LATS10.21731140
147GSK3B0.21076226
148PRKACA0.21030957
149EGFR0.20230769
150NTRK20.19778243
151KSR20.19749328
152PRKAA10.19543551
153CDK20.17576997
154SRC0.15619181
155SIK20.15012376
156CASK0.14948355
157MAPK10.14013488
158RPS6KA30.13915078
159DYRK20.12894998
160PBK0.11965233
161CAMK10.11854299

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.05270191
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.89464142
3Vitamin B6 metabolism_Homo sapiens_hsa007504.06316273
4Histidine metabolism_Homo sapiens_hsa003403.16098327
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.81883191
6Tyrosine metabolism_Homo sapiens_hsa003502.81794917
7Caffeine metabolism_Homo sapiens_hsa002322.78926454
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.72610818
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.70632133
10Fructose and mannose metabolism_Homo sapiens_hsa000512.67059317
11Phenylalanine metabolism_Homo sapiens_hsa003602.60391827
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.32254630
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.07774515
14Arachidonic acid metabolism_Homo sapiens_hsa005902.05454974
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96804134
16beta-Alanine metabolism_Homo sapiens_hsa004101.93843347
17Glutathione metabolism_Homo sapiens_hsa004801.85500259
18ECM-receptor interaction_Homo sapiens_hsa045121.84830098
19Galactose metabolism_Homo sapiens_hsa000521.80620936
20Oxidative phosphorylation_Homo sapiens_hsa001901.75968823
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.73619027
22Peroxisome_Homo sapiens_hsa041461.69912251
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67765877
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67267500
25Huntingtons disease_Homo sapiens_hsa050161.64255871
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62879016
27Folate biosynthesis_Homo sapiens_hsa007901.61842426
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60786708
29Linoleic acid metabolism_Homo sapiens_hsa005911.56619247
30Protein digestion and absorption_Homo sapiens_hsa049741.56281078
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51075746
32Other glycan degradation_Homo sapiens_hsa005111.50707541
33Retinol metabolism_Homo sapiens_hsa008301.50691715
34Taste transduction_Homo sapiens_hsa047421.48785394
35ABC transporters_Homo sapiens_hsa020101.44345105
36Tryptophan metabolism_Homo sapiens_hsa003801.44304191
37Protein export_Homo sapiens_hsa030601.43154800
38Hippo signaling pathway_Homo sapiens_hsa043901.42784898
39mTOR signaling pathway_Homo sapiens_hsa041501.41370331
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40484087
41Vitamin digestion and absorption_Homo sapiens_hsa049771.36854117
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35037330
43Ovarian steroidogenesis_Homo sapiens_hsa049131.34119049
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32518603
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31111092
46Proteasome_Homo sapiens_hsa030501.26948574
47Thyroid cancer_Homo sapiens_hsa052161.26512855
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26213945
49Hedgehog signaling pathway_Homo sapiens_hsa043401.24361473
50Tight junction_Homo sapiens_hsa045301.22930024
51Collecting duct acid secretion_Homo sapiens_hsa049661.22310584
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19610285
53Basal cell carcinoma_Homo sapiens_hsa052171.14789260
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.10810927
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10323872
56Bladder cancer_Homo sapiens_hsa052191.09810456
57Serotonergic synapse_Homo sapiens_hsa047261.09340571
58Adherens junction_Homo sapiens_hsa045201.08648444
59GABAergic synapse_Homo sapiens_hsa047271.06761095
60Olfactory transduction_Homo sapiens_hsa047401.05685984
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.04424918
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03963925
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03138730
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02893707
65Ether lipid metabolism_Homo sapiens_hsa005651.02300414
66Inositol phosphate metabolism_Homo sapiens_hsa005621.02142489
67Glutamatergic synapse_Homo sapiens_hsa047241.01761015
68Butanoate metabolism_Homo sapiens_hsa006501.01269849
69Rap1 signaling pathway_Homo sapiens_hsa040150.98929262
70Mineral absorption_Homo sapiens_hsa049780.97664732
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97634151
72Focal adhesion_Homo sapiens_hsa045100.95662332
73Sulfur relay system_Homo sapiens_hsa041220.95226450
74Nitrogen metabolism_Homo sapiens_hsa009100.93635452
75Choline metabolism in cancer_Homo sapiens_hsa052310.93093219
76Fatty acid degradation_Homo sapiens_hsa000710.92915218
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92477861
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92425974
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91869892
80Salivary secretion_Homo sapiens_hsa049700.91547747
81Pathways in cancer_Homo sapiens_hsa052000.90292950
82VEGF signaling pathway_Homo sapiens_hsa043700.88125916
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.86465915
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83863808
85GnRH signaling pathway_Homo sapiens_hsa049120.83721832
86Nicotine addiction_Homo sapiens_hsa050330.83708629
87Renin secretion_Homo sapiens_hsa049240.83174121
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.82393509
89Proteoglycans in cancer_Homo sapiens_hsa052050.82044671
90Parkinsons disease_Homo sapiens_hsa050120.81994676
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81832486
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81024926
93Starch and sucrose metabolism_Homo sapiens_hsa005000.80115342
94Metabolic pathways_Homo sapiens_hsa011000.77588352
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77512871
96Wnt signaling pathway_Homo sapiens_hsa043100.77246693
97Cardiac muscle contraction_Homo sapiens_hsa042600.76788571
98Arginine and proline metabolism_Homo sapiens_hsa003300.76586083
99Axon guidance_Homo sapiens_hsa043600.76244313
100Synaptic vesicle cycle_Homo sapiens_hsa047210.75709103
101N-Glycan biosynthesis_Homo sapiens_hsa005100.75104557
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.72858361
103Alzheimers disease_Homo sapiens_hsa050100.70535490
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69868878
105Arginine biosynthesis_Homo sapiens_hsa002200.69009145
106cAMP signaling pathway_Homo sapiens_hsa040240.68913888
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68302426
108Oxytocin signaling pathway_Homo sapiens_hsa049210.67371325
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.66812387
110Ras signaling pathway_Homo sapiens_hsa040140.64930146
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.64893932
112Fat digestion and absorption_Homo sapiens_hsa049750.62814870
113Long-term depression_Homo sapiens_hsa047300.62152187
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61409615
115Fatty acid elongation_Homo sapiens_hsa000620.59633684
116Dilated cardiomyopathy_Homo sapiens_hsa054140.59460551
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59397338
118Selenocompound metabolism_Homo sapiens_hsa004500.59261595
119Circadian rhythm_Homo sapiens_hsa047100.58799346
120Calcium signaling pathway_Homo sapiens_hsa040200.57170760
121Endocytosis_Homo sapiens_hsa041440.56671732
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.55972620
123MicroRNAs in cancer_Homo sapiens_hsa052060.55054480
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55036093
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54448544
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54434056
127Circadian entrainment_Homo sapiens_hsa047130.54270681
128Chemical carcinogenesis_Homo sapiens_hsa052040.53036557
129Sphingolipid metabolism_Homo sapiens_hsa006000.52534386
130Ribosome_Homo sapiens_hsa030100.52448824
131Dopaminergic synapse_Homo sapiens_hsa047280.52411509
132Long-term potentiation_Homo sapiens_hsa047200.51634595
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51606177
134Dorso-ventral axis formation_Homo sapiens_hsa043200.51245440
135Propanoate metabolism_Homo sapiens_hsa006400.51154405
136TGF-beta signaling pathway_Homo sapiens_hsa043500.48716589
137Lysosome_Homo sapiens_hsa041420.48028632
138Melanogenesis_Homo sapiens_hsa049160.46541447
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46367637
140ErbB signaling pathway_Homo sapiens_hsa040120.46100171
141Acute myeloid leukemia_Homo sapiens_hsa052210.45058366
142AMPK signaling pathway_Homo sapiens_hsa041520.44928736
143Renin-angiotensin system_Homo sapiens_hsa046140.44270327
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44235584
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44088375
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43749940
147Thyroid hormone synthesis_Homo sapiens_hsa049180.43635272
148Regulation of autophagy_Homo sapiens_hsa041400.42895328
149Homologous recombination_Homo sapiens_hsa034400.41597921
150Basal transcription factors_Homo sapiens_hsa030220.41492490
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40451924
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40053210
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39631652
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.39171586
155Small cell lung cancer_Homo sapiens_hsa052220.39007501
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.38338494
157Vibrio cholerae infection_Homo sapiens_hsa051100.38264959
158Glycerolipid metabolism_Homo sapiens_hsa005610.38223820
159Gastric acid secretion_Homo sapiens_hsa049710.37957844
160Endometrial cancer_Homo sapiens_hsa052130.37272988
161Non-small cell lung cancer_Homo sapiens_hsa052230.36021068
162PPAR signaling pathway_Homo sapiens_hsa033200.34901243
163Sulfur metabolism_Homo sapiens_hsa009200.34430816
164Insulin secretion_Homo sapiens_hsa049110.34014635
165Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32040021
166Fanconi anemia pathway_Homo sapiens_hsa034600.31708475
167Bile secretion_Homo sapiens_hsa049760.28912360
168Fatty acid metabolism_Homo sapiens_hsa012120.28797911

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