GRAMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.37491885
2epithelial cilium movement (GO:0003351)5.30696354
3cilium movement (GO:0003341)5.30579588
4negative T cell selection (GO:0043383)4.76681533
5tolerance induction (GO:0002507)4.68550130
6regulation of gamma-delta T cell differentiation (GO:0045586)4.51621609
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48912752
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48912752
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.46713772
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.40315231
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38694051
12L-phenylalanine catabolic process (GO:0006559)4.38694051
13negative thymic T cell selection (GO:0045060)4.36221819
14positive regulation of gamma-delta T cell activation (GO:0046645)4.25638168
15regulation of isotype switching to IgG isotypes (GO:0048302)4.21120058
16positive thymic T cell selection (GO:0045059)4.16881767
17interferon-gamma production (GO:0032609)4.13560800
18positive T cell selection (GO:0043368)4.12397436
19desmosome organization (GO:0002934)4.02230150
20activated T cell proliferation (GO:0050798)4.02021728
21antigen processing and presentation of endogenous antigen (GO:0019883)4.00564633
22response to interleukin-15 (GO:0070672)3.97906029
23L-phenylalanine metabolic process (GO:0006558)3.94312850
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94312850
25regulation of gamma-delta T cell activation (GO:0046643)3.93127212
26fatty acid elongation (GO:0030497)3.83925572
27cilium or flagellum-dependent cell motility (GO:0001539)3.79702022
28thymic T cell selection (GO:0045061)3.78522811
29cellular response to interleukin-15 (GO:0071350)3.78433930
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.77749673
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.74323459
32negative regulation of cell killing (GO:0031342)3.74323459
33motile cilium assembly (GO:0044458)3.71761674
34negative regulation of bone resorption (GO:0045779)3.68636568
35T cell selection (GO:0045058)3.59966017
36regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.56208980
37negative regulation of interleukin-1 beta production (GO:0032691)3.52568146
38creatine metabolic process (GO:0006600)3.51223049
39intestinal cholesterol absorption (GO:0030299)3.49420335
40COPI coating of Golgi vesicle (GO:0048205)3.47875219
41Golgi transport vesicle coating (GO:0048200)3.47875219
42T cell migration (GO:0072678)3.36599049
43signal peptide processing (GO:0006465)3.36314096
44axon ensheathment in central nervous system (GO:0032291)3.34459588
45central nervous system myelination (GO:0022010)3.34459588
46regulation of T cell tolerance induction (GO:0002664)3.33055578
47COPII vesicle coating (GO:0048208)3.27788387
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24922287
49axoneme assembly (GO:0035082)3.18944717
50T cell receptor signaling pathway (GO:0050852)3.17712468
51endocrine pancreas development (GO:0031018)3.15169137
52regulation of extracellular matrix disassembly (GO:0010715)3.14322697
53alpha-linolenic acid metabolic process (GO:0036109)3.13756177
54regulation of chronic inflammatory response (GO:0002676)3.06942612
55aromatic amino acid family catabolic process (GO:0009074)3.05930156
56leukocyte aggregation (GO:0070486)3.01488567
57valine metabolic process (GO:0006573)3.00175179
58regulation of cholesterol homeostasis (GO:2000188)2.99267910
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97054997
60cholesterol biosynthetic process (GO:0006695)2.94669884
61skin morphogenesis (GO:0043589)2.94080377
62pericardium development (GO:0060039)2.89971459
63positive regulation of interleukin-2 production (GO:0032743)2.89910333
64regulation of integrin-mediated signaling pathway (GO:2001044)2.89586872
65macroautophagy (GO:0016236)2.89030084
66negative regulation of bone remodeling (GO:0046851)2.88587935
67very long-chain fatty acid metabolic process (GO:0000038)2.88036299
68negative regulation of tissue remodeling (GO:0034104)2.84717541
69regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83936189
70regulation of interleukin-2 biosynthetic process (GO:0045076)2.83903238
71long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83594900
72response to muramyl dipeptide (GO:0032495)2.83566268
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82775932
74T cell costimulation (GO:0031295)2.78890157
75viral protein processing (GO:0019082)2.75229926
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74683715
77fatty-acyl-CoA biosynthetic process (GO:0046949)2.73869946
78positive regulation of tolerance induction (GO:0002645)2.71593944
79heterotypic cell-cell adhesion (GO:0034113)2.71266070
80negative regulation of interleukin-1 production (GO:0032692)2.71195893
81lymphocyte costimulation (GO:0031294)2.70522692
82intestinal absorption (GO:0050892)2.68501100
83nucleotide transmembrane transport (GO:1901679)2.67886738
84hemidesmosome assembly (GO:0031581)2.66669080
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65307622
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65120307
87amyloid precursor protein catabolic process (GO:0042987)2.64271737
88antigen receptor-mediated signaling pathway (GO:0050851)2.62118524
89regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60846348
90sphingoid metabolic process (GO:0046519)2.59881408
91ADP metabolic process (GO:0046031)2.59876679
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58914357
93T-helper cell differentiation (GO:0042093)2.58914357
94sulfur amino acid catabolic process (GO:0000098)2.57401397
95regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.55611453
96cysteine metabolic process (GO:0006534)2.54175038
97mesenchymal-epithelial cell signaling (GO:0060638)2.52888512
98regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52183510
99regulation of cholesterol biosynthetic process (GO:0045540)2.50953510
100smooth muscle tissue development (GO:0048745)2.50680223
101regulation of alpha-beta T cell proliferation (GO:0046640)2.49839679
102regulation of cholesterol metabolic process (GO:0090181)2.48322980
103ensheathment of neurons (GO:0007272)2.47914398
104axon ensheathment (GO:0008366)2.47914398
105protein K11-linked deubiquitination (GO:0035871)2.47334909
106phospholipid efflux (GO:0033700)2.47145900
107myelination (GO:0042552)2.46767190
108bile acid biosynthetic process (GO:0006699)2.46440247
109acyl-CoA biosynthetic process (GO:0071616)2.45749635
110thioester biosynthetic process (GO:0035384)2.45749635
111gap junction assembly (GO:0016264)2.45709181
112positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.44806140
113positive regulation of natural killer cell mediated immunity (GO:0002717)2.44806140
114tonic smooth muscle contraction (GO:0014820)2.44201941
115negative regulation of osteoblast proliferation (GO:0033689)2.43798641
116sterol biosynthetic process (GO:0016126)2.43719608
117sequestering of extracellular ligand from receptor (GO:0035581)2.43052020
118plasma lipoprotein particle assembly (GO:0034377)2.42078604
119collagen fibril organization (GO:0030199)2.41825528
120UDP-N-acetylglucosamine metabolic process (GO:0006047)2.41792580
121response to gravity (GO:0009629)2.41468546
122glomerular basement membrane development (GO:0032836)2.39984765
123peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39955212
124one-carbon compound transport (GO:0019755)2.39152581
125negative regulation of glycoprotein biosynthetic process (GO:0010561)2.38511557
126coenzyme catabolic process (GO:0009109)2.38453824
127adhesion of symbiont to host cell (GO:0044650)2.37923717
128virion attachment to host cell (GO:0019062)2.37923717
129alpha-beta T cell differentiation (GO:0046632)2.37836545
130fatty-acyl-CoA metabolic process (GO:0035337)2.36447546
131negative regulation of cholesterol transport (GO:0032375)2.36265020
132negative regulation of sterol transport (GO:0032372)2.36265020
133high-density lipoprotein particle remodeling (GO:0034375)2.35746631
134glomerular epithelial cell development (GO:0072310)2.34911844
135bundle of His cell to Purkinje myocyte communication (GO:0086069)2.34502055
136xenobiotic catabolic process (GO:0042178)2.33104741
137glutathione derivative metabolic process (GO:1901685)2.32786282
138glutathione derivative biosynthetic process (GO:1901687)2.32786282
139regulation of type B pancreatic cell apoptotic process (GO:2000674)2.32457388
140negative regulation of complement activation (GO:0045916)2.32390779
141negative regulation of protein localization to cell surface (GO:2000009)2.32293101
142metanephric mesenchyme development (GO:0072075)2.25748813
143left/right pattern formation (GO:0060972)2.25249124
144kidney mesenchyme development (GO:0072074)2.22197876
145positive regulation of actin filament depolymerization (GO:0030836)2.19894490
146sphingosine metabolic process (GO:0006670)2.19497257
147endocardial cushion development (GO:0003197)2.19387973
148type B pancreatic cell proliferation (GO:0044342)2.18827884
149retinal cone cell development (GO:0046549)2.18636801
150retinol metabolic process (GO:0042572)2.18468051
151cilium morphogenesis (GO:0060271)2.18217593
152dermatan sulfate biosynthetic process (GO:0030208)2.15438086
153import into cell (GO:0098657)2.15283835
154nephron tubule formation (GO:0072079)2.13948144
155determination of left/right symmetry (GO:0007368)2.12970764
156diol metabolic process (GO:0034311)2.12525552
157auditory receptor cell differentiation (GO:0042491)2.12305621
158positive regulation of p38MAPK cascade (GO:1900745)2.12188190
159regulation of keratinocyte proliferation (GO:0010837)2.11183742
160regulation of transforming growth factor beta1 production (GO:0032908)2.09441693
161regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.09263347
162sphingomyelin metabolic process (GO:0006684)2.09125775
163membrane assembly (GO:0071709)2.09030809
164positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.08094746
165sleep (GO:0030431)2.06990193
166positive regulation of osteoblast proliferation (GO:0033690)2.05056978
167regulation of osteoblast proliferation (GO:0033688)2.04936253
168cell adhesion mediated by integrin (GO:0033627)2.04464534
169glomerular visceral epithelial cell development (GO:0072015)2.04414050
170artery smooth muscle contraction (GO:0014824)2.02885174
171negative regulation of protein activation cascade (GO:2000258)2.01374523
172negative regulation of hormone biosynthetic process (GO:0032353)2.01102127
173atrial cardiac muscle cell action potential (GO:0086014)2.01015578
174endocrine hormone secretion (GO:0060986)1.99884382
175extracellular matrix assembly (GO:0085029)1.99617669
176vascular smooth muscle contraction (GO:0014829)1.99235852
177keratinocyte proliferation (GO:0043616)1.98861753
178cellular potassium ion homeostasis (GO:0030007)1.98647167
179determination of bilateral symmetry (GO:0009855)1.97692556
180chondrocyte proliferation (GO:0035988)1.96744162
181cellular ketone body metabolic process (GO:0046950)1.96571830
182regulation of p38MAPK cascade (GO:1900744)1.95669428
183specification of symmetry (GO:0009799)1.95013565
184ventricular system development (GO:0021591)1.94855932
185urinary tract smooth muscle contraction (GO:0014848)1.94692850
186peptide hormone processing (GO:0016486)1.93720970
187peripheral nervous system development (GO:0007422)1.93399773
188regulation of cilium movement (GO:0003352)1.93292563
189diterpenoid biosynthetic process (GO:0016102)1.93291663
190renal filtration (GO:0097205)1.91913863
191thyroid hormone metabolic process (GO:0042403)1.91863122
192dermatan sulfate metabolic process (GO:0030205)1.91307095
193multicellular organismal water homeostasis (GO:0050891)1.91232734
194negative regulation of cytosolic calcium ion concentration (GO:0051481)1.90677513
195response to redox state (GO:0051775)1.90264136
196negative regulation of hormone metabolic process (GO:0032351)1.90004704
197cilium organization (GO:0044782)1.89892128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.33287689
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.48000692
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38865457
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.71239118
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48932653
6RUNX_20019798_ChIP-Seq_JUKART_Human3.37360867
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.36049303
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.31336840
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.18661285
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.88423649
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86495720
12* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56342186
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49156526
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45674827
15* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37819045
16GBX2_23144817_ChIP-Seq_PC3_Human2.35267959
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30449969
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.30261331
19MYB_26560356_Chip-Seq_TH2_Human2.16847893
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12500507
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09428907
22CJUN_26792858_Chip-Seq_BT549_Human2.06714121
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.04593687
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03097797
25* PIAS1_25552417_ChIP-Seq_VCAP_Human1.99347827
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96969904
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92712221
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89271191
29TP53_18474530_ChIP-ChIP_U2OS_Human1.85346764
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84025406
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81630360
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.80650179
33GATA3_27048872_Chip-Seq_THYMUS_Human1.79286072
34MYB_26560356_Chip-Seq_TH1_Human1.77853252
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77489060
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77051314
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72914809
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72235620
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71508378
40* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71330348
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71150858
42MAF_26560356_Chip-Seq_TH1_Human1.70075218
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68915036
44* EP300_21415370_ChIP-Seq_HL-1_Mouse1.63503616
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62404127
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62404127
47CLOCK_20551151_ChIP-Seq_293T_Human1.61215233
48AHR_22903824_ChIP-Seq_MCF-7_Human1.60567829
49TP53_16413492_ChIP-PET_HCT116_Human1.56765429
50* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55478172
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54827554
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53614582
53* BRD4_25478319_ChIP-Seq_HGPS_Human1.53167734
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.52790609
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.52383085
56* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51217739
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49231711
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45577003
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45249813
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44982213
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.43905952
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43776403
63UTX_26944678_Chip-Seq_JUKART_Human1.42019761
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41954501
65MYC_22102868_ChIP-Seq_BL_Human1.41646865
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40589681
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40266967
68* TP63_23658742_ChIP-Seq_EP156T_Human1.39959574
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38421625
70* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38329910
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36618986
72* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36443932
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35085970
74* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34918229
75GATA1_22025678_ChIP-Seq_K562_Human1.34087487
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31461122
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28753754
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.28099301
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.27117689
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.26811484
81* P300_19829295_ChIP-Seq_ESCs_Human1.26136357
82* STAT3_23295773_ChIP-Seq_U87_Human1.26096536
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25539830
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24917882
85FOXA1_25552417_ChIP-Seq_VCAP_Human1.22759956
86GATA1_19941826_ChIP-Seq_K562_Human1.22424338
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22321717
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21227904
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20342087
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20245696
91* CDX2_22108803_ChIP-Seq_LS180_Human1.20192119
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19713650
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.19566664
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.18580784
95* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18011874
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17755806
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17190241
98BCAT_22108803_ChIP-Seq_LS180_Human1.16704056
99MAF_26560356_Chip-Seq_TH2_Human1.15822835
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14972095
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13491854
102* SMAD3_21741376_ChIP-Seq_EPCs_Human1.13471067
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13425027
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.13244060
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12716034
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11767151
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11004219
108TCF4_22108803_ChIP-Seq_LS180_Human1.10799612
109GATA3_26560356_Chip-Seq_TH2_Human1.10415103
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.10186416
111* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09302389
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09216506
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07338578
114* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06644886
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06462983
116GATA4_25053715_ChIP-Seq_YYC3_Human1.04465384
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04284660
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04061688
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04061688
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03421896
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.02353166
122GATA2_19941826_ChIP-Seq_K562_Human1.02305951
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01389592
124* AR_25329375_ChIP-Seq_VCAP_Human0.99982063
125KDM2B_26808549_Chip-Seq_DND41_Human0.99957682
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99191988
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99139172
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98877806
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98599427
130* TCF4_23295773_ChIP-Seq_U87_Human0.98551879
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98448146
132EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98355219
133RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98355219
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98217347
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.97940190
136VDR_24787735_ChIP-Seq_THP-1_Human0.96920283
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95367746
138VDR_24763502_ChIP-Seq_THP-1_Human0.94888724
139SOX2_20726797_ChIP-Seq_SW620_Human0.94883742
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.93142838
141EZH2_27294783_Chip-Seq_NPCs_Mouse0.92960124
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.92686104
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92600531
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.92555866
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92274162
146DROSHA_22980978_ChIP-Seq_HELA_Human0.91994691
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91357673
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91105503
149* FUS_26573619_Chip-Seq_HEK293_Human0.90906445
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90329858
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89454825
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88937524
153TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87391279
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87159303
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86872250
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86782889
157TCF7_22412390_ChIP-Seq_EML_Mouse0.86030792
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83224926
159* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82671572
160* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82108939
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79832111
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79585466
163GATA6_25053715_ChIP-Seq_YYC3_Human0.79552067
164GATA2_21666600_ChIP-Seq_HMVEC_Human0.78603135
165TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78176556
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.77406822
167WT1_19549856_ChIP-ChIP_CCG9911_Human0.76838068
168* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76357724
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76230136
170Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75647819
171* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75470276
172EGR1_19032775_ChIP-ChIP_M12_Human0.75001828
173CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74904362
174* PU_27001747_Chip-Seq_BMDM_Mouse0.73966012
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73716362
176SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73597143
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72593072
178P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71569321
179KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69684968
180VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69385782
181KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.68590977
182GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68467324
183TBX20_22328084_ChIP-Seq_HEART_Mouse0.67943564
184TBX20_22080862_ChIP-Seq_HEART_Mouse0.67943564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.13504224
2MP0002139_abnormal_hepatobiliary_system4.00497708
3MP0003950_abnormal_plasma_membrane4.00030682
4MP0003763_abnormal_thymus_physiology3.70181935
5MP0005360_urolithiasis3.37091966
6MP0005365_abnormal_bile_salt3.36623728
7MP0005275_abnormal_skin_tensile3.26000939
8MP0005503_abnormal_tendon_morphology2.97043214
9MP0004272_abnormal_basement_membrane2.88607563
10MP0001666_abnormal_nutrient_absorption2.85989736
11MP0000685_abnormal_immune_system2.77275963
12MP0005085_abnormal_gallbladder_physiolo2.67013787
13MP0002138_abnormal_hepatobiliary_system2.65445636
14MP0003279_aneurysm2.44634327
15MP0005671_abnormal_response_to2.40177470
16MP0003300_gastrointestinal_ulcer2.32442229
17MP0003806_abnormal_nucleotide_metabolis2.31818778
18MP0004947_skin_inflammation2.30805139
19MP0001790_abnormal_immune_system2.30372112
20MP0005387_immune_system_phenotype2.30372112
21MP0010386_abnormal_urinary_bladder2.25116216
22MP0000920_abnormal_myelination2.19413657
23MP0008875_abnormal_xenobiotic_pharmacok2.17014607
24MP0003252_abnormal_bile_duct2.16183608
25MP0009840_abnormal_foam_cell2.12116611
26MP0003195_calcinosis2.08712449
27MP0001800_abnormal_humoral_immune2.06386479
28MP0006082_CNS_inflammation2.02615775
29MP0003183_abnormal_peptide_metabolism1.99291905
30MP0002876_abnormal_thyroid_physiology1.98271226
31MP0001958_emphysema1.96549843
32MP0003879_abnormal_hair_cell1.93063285
33MP0001984_abnormal_olfaction1.92714588
34MP0005000_abnormal_immune_tolerance1.89804180
35MP0003868_abnormal_feces_composition1.88043415
36MP0002166_altered_tumor_susceptibility1.87305285
37MP0005083_abnormal_biliary_tract1.77624894
38MP0005023_abnormal_wound_healing1.76480541
39MP0002837_dystrophic_cardiac_calcinosis1.75141466
40MP0002723_abnormal_immune_serum1.74318321
41MP0002693_abnormal_pancreas_physiology1.71282251
42MP0004043_abnormal_pH_regulation1.70446953
43MP0002295_abnormal_pulmonary_circulatio1.67667475
44MP0005171_absent_coat_pigmentation1.67564016
45MP0000609_abnormal_liver_physiology1.67302130
46MP0003329_amyloid_beta_deposits1.66256860
47MP0005257_abnormal_intraocular_pressure1.65375169
48MP0010678_abnormal_skin_adnexa1.61346736
49MP0004019_abnormal_vitamin_homeostasis1.61126802
50MP0002933_joint_inflammation1.59709848
51MP0003690_abnormal_glial_cell1.59461763
52MP0010368_abnormal_lymphatic_system1.56575956
53MP0001501_abnormal_sleep_pattern1.56199129
54MP0002420_abnormal_adaptive_immunity1.55458831
55MP0009643_abnormal_urine_homeostasis1.53342310
56MP0003866_abnormal_defecation1.52821487
57MP0003941_abnormal_skin_development1.52528862
58MP0003283_abnormal_digestive_organ1.51825007
59MP0001819_abnormal_immune_cell1.50530143
60MP0005220_abnormal_exocrine_pancreas1.49496036
61MP0000604_amyloidosis1.48525696
62MP0005310_abnormal_salivary_gland1.48103192
63MP0005451_abnormal_body_composition1.45256929
64MP0002452_abnormal_antigen_presenting1.44045167
65MP0010329_abnormal_lipoprotein_level1.41015114
66MP0009333_abnormal_splenocyte_physiolog1.40858664
67MP0001542_abnormal_bone_strength1.40660245
68MP0000579_abnormal_nail_morphology1.40549628
69MP0002118_abnormal_lipid_homeostasis1.39671460
70MP0004381_abnormal_hair_follicle1.38920582
71MP0010155_abnormal_intestine_physiology1.37844477
72MP0001944_abnormal_pancreas_morphology1.36323729
73MP0005332_abnormal_amino_acid1.34974847
74MP0002254_reproductive_system_inflammat1.34015365
75MP0005595_abnormal_vascular_smooth1.32590773
76MP0003724_increased_susceptibility_to1.31851448
77MP0000383_abnormal_hair_follicle1.29683273
78MP0002405_respiratory_system_inflammati1.29247179
79MP0005025_abnormal_response_to1.27782032
80MP0001873_stomach_inflammation1.26896445
81MP0000716_abnormal_immune_system1.26848736
82MP0000538_abnormal_urinary_bladder1.26815867
83MP0001845_abnormal_inflammatory_respons1.25463860
84MP0004185_abnormal_adipocyte_glucose1.24498136
85MP0001756_abnormal_urination1.24052541
86MP0002006_tumorigenesis1.23529475
87MP0003705_abnormal_hypodermis_morpholog1.23495165
88MP0003566_abnormal_cell_adhesion1.20686501
89MP0002653_abnormal_ependyma_morphology1.20362881
90MP0010234_abnormal_vibrissa_follicle1.20240028
91MP0001835_abnormal_antigen_presentation1.20134725
92MP0010352_gastrointestinal_tract_polyps1.19344196
93MP0002909_abnormal_adrenal_gland1.18461098
94MP0002896_abnormal_bone_mineralization1.18044861
95MP0009384_cardiac_valve_regurgitation1.17877705
96MP0002398_abnormal_bone_marrow1.16763325
97MP0005623_abnormal_meninges_morphology1.16676813
98MP0001851_eye_inflammation1.16230213
99MP0002734_abnormal_mechanical_nocicepti1.15488179
100MP0001243_abnormal_dermal_layer1.13102352
101MP0003436_decreased_susceptibility_to1.12088355
102MP0005058_abnormal_lysosome_morphology1.11952259
103MP0005508_abnormal_skeleton_morphology1.11273558
104MP0004885_abnormal_endolymph1.11010985
105MP0000613_abnormal_salivary_gland1.10816674
106MP0005408_hypopigmentation1.09963175
107MP0001502_abnormal_circadian_rhythm1.08885836
108MP0000427_abnormal_hair_cycle1.07745719
109MP0003091_abnormal_cell_migration1.07685565
110MP0009785_altered_susceptibility_to1.07567001
111MP0001661_extended_life_span1.05963847
112MP0009780_abnormal_chondrocyte_physiolo1.04725813
113MP0008469_abnormal_protein_level1.03662873
114MP0005379_endocrine/exocrine_gland_phen1.02836136
115MP0000230_abnormal_systemic_arterial1.02699635
116MP0002877_abnormal_melanocyte_morpholog1.02667126
117MP0002108_abnormal_muscle_morphology1.02409786
118MP0003453_abnormal_keratinocyte_physiol1.02380795
119MP0000703_abnormal_thymus_morphology1.01332706
120MP0001348_abnormal_lacrimal_gland1.00902250
121MP0002078_abnormal_glucose_homeostasis1.00728123
122MP0002168_other_aberrant_phenotype1.00028255
123MP0005165_increased_susceptibility_to0.99053559
124MP0005584_abnormal_enzyme/coenzyme_acti0.98787446
125MP0003045_fibrosis0.98537432
126MP0002419_abnormal_innate_immunity0.98346717
127MP0005551_abnormal_eye_electrophysiolog0.98232152
128MP0004270_analgesia0.96956746
129MP0002272_abnormal_nervous_system0.96886816
130MP0000013_abnormal_adipose_tissue0.96178564
131MP0000762_abnormal_tongue_morphology0.95939850
132MP0005164_abnormal_response_to0.94584348
133MP0002148_abnormal_hypersensitivity_rea0.93200822
134MP0009250_abnormal_appendicular_skeleto0.91882176
135MP0001533_abnormal_skeleton_physiology0.91779946
136MP0001299_abnormal_eye_distance/0.91720704
137MP0000689_abnormal_spleen_morphology0.90679343
138MP0001765_abnormal_ion_homeostasis0.90465210
139MP0009765_abnormal_xenobiotic_induced0.90310038
140MP0002998_abnormal_bone_remodeling0.89924231
141MP0009046_muscle_twitch0.89122114
142MP0004147_increased_porphyrin_level0.89109292
143MP0001853_heart_inflammation0.88516513
144MP0000749_muscle_degeneration0.88330727
145MP0002429_abnormal_blood_cell0.87650673
146MP0002722_abnormal_immune_system0.86992498
147MP0004510_myositis0.86873882
148MP0001664_abnormal_digestion0.86660904
149MP0000003_abnormal_adipose_tissue0.85487624
150MP0004215_abnormal_myocardial_fiber0.83512738
151MP0002136_abnormal_kidney_physiology0.82817086
152MP0003191_abnormal_cellular_cholesterol0.81385718
153MP0004133_heterotaxia0.81211433
154MP0004264_abnormal_extraembryonic_tissu0.81156431
155MP0005620_abnormal_muscle_contractility0.80705092
156MP0000462_abnormal_digestive_system0.80059857
157MP0006054_spinal_hemorrhage0.79794555
158MP0000569_abnormal_digit_pigmentation0.79239089
159MP0009763_increased_sensitivity_to0.78970907
160MP0005636_abnormal_mineral_homeostasis0.78500895
161MP0003136_yellow_coat_color0.77950815
162MP0010030_abnormal_orbit_morphology0.76399522
163MP0002060_abnormal_skin_morphology0.75123808
164MP0001216_abnormal_epidermal_layer0.75065899
165MP0002796_impaired_skin_barrier0.73939899
166MP0010771_integument_phenotype0.73911121
167MP0000767_abnormal_smooth_muscle0.73743913
168MP0005367_renal/urinary_system_phenotyp0.72124549
169MP0000516_abnormal_urinary_system0.72124549
170MP0000534_abnormal_ureter_morphology0.71513846
171MP0009745_abnormal_behavioral_response0.71380842
172MP0004883_abnormal_blood_vessel0.67112518
173MP0002938_white_spotting0.64484498
174MP0001970_abnormal_pain_threshold0.64302960
175MP0002282_abnormal_trachea_morphology0.64214725
176MP0003633_abnormal_nervous_system0.63754002
177MP0003075_altered_response_to0.62433723

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.45389818
2Abnormal respiratory motile cilium physiology (HP:0012261)5.20170051
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.89254471
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.75408545
5T lymphocytopenia (HP:0005403)4.73410760
6Abnormal respiratory motile cilium morphology (HP:0005938)4.72800453
7Abnormal respiratory epithelium morphology (HP:0012253)4.72800453
8Stomatitis (HP:0010280)4.67656193
9Absent/shortened dynein arms (HP:0200106)4.60047665
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.60047665
11Abnormality of T cell number (HP:0011839)4.54133784
12Rhinitis (HP:0012384)4.36963968
13Intrahepatic cholestasis (HP:0001406)4.23887370
14Hypoglycemic coma (HP:0001325)4.05084245
15Hypoglycemic seizures (HP:0002173)3.86384741
16Xanthomatosis (HP:0000991)3.71698557
17Hyperinsulinemic hypoglycemia (HP:0000825)3.69904074
18Symptomatic seizures (HP:0011145)3.46907264
19Premature rupture of membranes (HP:0001788)3.40729088
20Cardiovascular calcification (HP:0011915)3.36854317
21Protrusio acetabuli (HP:0003179)3.31518197
22Ketoacidosis (HP:0001993)3.24858713
23Severe combined immunodeficiency (HP:0004430)3.24206604
24Conjugated hyperbilirubinemia (HP:0002908)3.20808825
25Neurofibrillary tangles (HP:0002185)3.19523422
26Popliteal pterygium (HP:0009756)3.18501359
27Abnormality of the pancreatic islet cells (HP:0006476)3.16071356
28Abnormality of endocrine pancreas physiology (HP:0012093)3.16071356
29Hyperlipoproteinemia (HP:0010980)3.13735551
30Hypobetalipoproteinemia (HP:0003563)3.13094144
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08683582
32Ketosis (HP:0001946)3.06415541
33Aortic dissection (HP:0002647)3.05967905
34Bronchiectasis (HP:0002110)3.04668606
35Fat malabsorption (HP:0002630)3.02677806
36Elevated erythrocyte sedimentation rate (HP:0003565)3.02448387
37Abnormality of T cells (HP:0002843)3.00363625
38Deep venous thrombosis (HP:0002625)2.99627421
39Prolonged partial thromboplastin time (HP:0003645)2.94026178
40Chronic diarrhea (HP:0002028)2.92337680
41Aortic aneurysm (HP:0004942)2.91328387
42Vascular calcification (HP:0004934)2.90468018
43Recurrent bronchitis (HP:0002837)2.90029368
44Combined immunodeficiency (HP:0005387)2.89870828
45Abnormality of dentin (HP:0010299)2.87584573
46Chronic otitis media (HP:0000389)2.86600449
47Chronic bronchitis (HP:0004469)2.81291497
48Nasal polyposis (HP:0100582)2.81220501
49Late onset (HP:0003584)2.80515228
50Abnormality of the common coagulation pathway (HP:0010990)2.80070383
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76204098
52Atrophic scars (HP:0001075)2.74502133
53Vascular tortuosity (HP:0004948)2.74129939
54Follicular hyperkeratosis (HP:0007502)2.71029488
55Pancreatic islet-cell hyperplasia (HP:0004510)2.61697947
56Dysostosis multiplex (HP:0000943)2.59737215
57Tubular atrophy (HP:0000092)2.59055457
58Generalized aminoaciduria (HP:0002909)2.58417318
59Large for gestational age (HP:0001520)2.52706520
60Autoimmune hemolytic anemia (HP:0001890)2.51806420
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.51078085
62Hypoplasia of the thymus (HP:0000778)2.50854417
63Abnormality of the intrinsic pathway (HP:0010989)2.49985036
64IgG deficiency (HP:0004315)2.47853864
65Spondylolisthesis (HP:0003302)2.43722048
66Arterial tortuosity (HP:0005116)2.41691767
67Pancreatic fibrosis (HP:0100732)2.41403245
68Glucose intolerance (HP:0000833)2.39929887
69Hyperglycemia (HP:0003074)2.38121486
70Abnormality of eosinophils (HP:0001879)2.37926385
71Thyroiditis (HP:0100646)2.33244704
72Steatorrhea (HP:0002570)2.33103674
73Premature skin wrinkling (HP:0100678)2.32508201
74Recurrent sinusitis (HP:0011108)2.30989620
75Pancreatic cysts (HP:0001737)2.30525771
76Gastrointestinal stroma tumor (HP:0100723)2.27997104
77Neonatal short-limb short stature (HP:0008921)2.22526596
78Acute hepatic failure (HP:0006554)2.20347780
79Recurrent viral infections (HP:0004429)2.18107542
80Abnormality of midbrain morphology (HP:0002418)2.16458622
81Molar tooth sign on MRI (HP:0002419)2.16458622
82Increased IgM level (HP:0003496)2.15965580
83Pancreatitis (HP:0001733)2.15327823
84Cerebral inclusion bodies (HP:0100314)2.12846283
85Abnormality of B cell number (HP:0010975)2.12291740
86B lymphocytopenia (HP:0010976)2.12291740
87Broad metatarsal (HP:0001783)2.11758576
88Abnormality of serine family amino acid metabolism (HP:0010894)2.11686610
89Abnormality of glycine metabolism (HP:0010895)2.11686610
90Abnormality of proline metabolism (HP:0010907)2.11264309
91Hydroxyprolinuria (HP:0003080)2.11264309
92True hermaphroditism (HP:0010459)2.11172337
93Bell-shaped thorax (HP:0001591)2.10632712
94Nephronophthisis (HP:0000090)2.10554514
95Protuberant abdomen (HP:0001538)2.09666542
96Abnormality of the nasal mucosa (HP:0000433)2.08579093
97Lymphopenia (HP:0001888)2.08055120
98Abnormal glucose tolerance (HP:0001952)2.08018917
99Sensory axonal neuropathy (HP:0003390)2.07964640
100Myocardial infarction (HP:0001658)2.07110732
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06644113
102Short nail (HP:0001799)2.06249216
103Abnormal delayed hypersensitivity skin test (HP:0002963)2.06095660
104Abnormality of sulfur amino acid metabolism (HP:0004339)2.05546935
105Medial flaring of the eyebrow (HP:0010747)2.05504539
106IgM deficiency (HP:0002850)2.05342074
107Epidermoid cyst (HP:0200040)2.04581007
108Eosinophilia (HP:0001880)2.04328773
109Abnormality of fatty-acid metabolism (HP:0004359)2.03977324
110Abnormality of T cell physiology (HP:0011840)2.03877462
111Coronal craniosynostosis (HP:0004440)2.03416037
112Joint swelling (HP:0001386)2.00928546
113Hypolipoproteinemia (HP:0010981)1.99977884
114Stage 5 chronic kidney disease (HP:0003774)1.98495239
115Soft skin (HP:0000977)1.98182691
116Abnormality of molar morphology (HP:0011070)1.98131506
117Abnormality of molar (HP:0011077)1.98131506
118Abnormal foot bone ossification (HP:0010675)1.98001923
119Mucopolysacchariduria (HP:0008155)1.97619426
120Urinary glycosaminoglycan excretion (HP:0003541)1.97619426
121Cystic liver disease (HP:0006706)1.97432735
122Action tremor (HP:0002345)1.97130356
123Vacuolated lymphocytes (HP:0001922)1.97128881
124Abdominal distention (HP:0003270)1.96803395
125Hyperammonemia (HP:0001987)1.93357560
126Hemiparesis (HP:0001269)1.92906446
127Congenital sensorineural hearing impairment (HP:0008527)1.92895337
128Mitral stenosis (HP:0001718)1.92867737
129Occipital encephalocele (HP:0002085)1.92643093
130Hyperglycinuria (HP:0003108)1.92241953
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.92106629
132Gastrointestinal infarctions (HP:0005244)1.91248259
133Metabolic alkalosis (HP:0200114)1.91236050
134Delayed gross motor development (HP:0002194)1.91115654
135Abnormality of methionine metabolism (HP:0010901)1.91057720
136Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88429046
137Furrowed tongue (HP:0000221)1.87259218
138Increased CSF protein (HP:0002922)1.86699446
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86153871
140Infertility (HP:0000789)1.85364070
141Abnormality of calcium-phosphate metabolism (HP:0100530)1.85190194
142Recurrent fungal infections (HP:0002841)1.84080370
143Metaphyseal dysplasia (HP:0100255)1.83876188
144Pulmonary embolism (HP:0002204)1.83452314
145Nonprogressive disorder (HP:0003680)1.83308785
146IgA deficiency (HP:0002720)1.83248824
147Abnormality of the renal medulla (HP:0100957)1.82878540
148Limb hypertonia (HP:0002509)1.82615086
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.82522557
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82522557
151Hypoplastic labia majora (HP:0000059)1.81637047
152Aplasia of the musculature (HP:0100854)1.81631950
153Abnormality of the dental pulp (HP:0006479)1.77558630
154Bronchitis (HP:0012387)1.77384052
155Chronic sinusitis (HP:0011109)1.77086653
156Wormian bones (HP:0002645)1.77084032
157Renal cortical cysts (HP:0000803)1.76873197
158Vasculitis (HP:0002633)1.75747341
159Peripheral hypomyelination (HP:0007182)1.75723637
160Abnormal tarsal ossification (HP:0008369)1.75386053
161Gait imbalance (HP:0002141)1.75309203
162Cervical subluxation (HP:0003308)1.75186006
163Parakeratosis (HP:0001036)1.74796522
164Panhypogammaglobulinemia (HP:0003139)1.74561186
165Bradycardia (HP:0001662)1.74527411
166Bladder diverticulum (HP:0000015)1.73601631
167Abnormal drinking behavior (HP:0030082)1.73536510
168Polydipsia (HP:0001959)1.73536510
169Abnormality of the dental root (HP:0006486)1.71999201
170Taurodontia (HP:0000679)1.71999201
171Abnormality of permanent molar morphology (HP:0011071)1.71999201
172Hypothermia (HP:0002045)1.69275985
173Tubulointerstitial fibrosis (HP:0005576)1.68426015
174Right ventricular cardiomyopathy (HP:0011663)1.68058001
175Aplasia/Hypoplasia of the tongue (HP:0010295)1.67625431
176Abnormality of the labia majora (HP:0012881)1.66851716
177Hyperactive renin-angiotensin system (HP:0000841)1.65601380
178Short hallux (HP:0010109)1.65462899
179Congenital primary aphakia (HP:0007707)1.65365189
180Pigmentary retinal degeneration (HP:0001146)1.61543848
181Short thorax (HP:0010306)1.59652632
182Increased circulating renin level (HP:0000848)1.59542488
183Abnormality of the renal cortex (HP:0011035)1.56844498
184Aplasia involving bones of the upper limbs (HP:0009823)1.56641103
185Aplasia of the phalanges of the hand (HP:0009802)1.56641103
186Aplasia involving bones of the extremities (HP:0009825)1.56641103
187Aplasia/Hypoplasia of the hallux (HP:0008362)1.56498877
188Overgrowth (HP:0001548)1.54532589
189Pterygium (HP:0001059)1.54326304
190Hyporeflexia of lower limbs (HP:0002600)1.52596293
191Shallow orbits (HP:0000586)1.52372846
192Fragile skin (HP:0001030)1.51667693
193Increased corneal curvature (HP:0100692)1.51521255
194Keratoconus (HP:0000563)1.51521255
195Aortic regurgitation (HP:0001659)1.51474887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.72130440
2ITK3.57343787
3MYLK3.19097010
4TXK3.14992521
5STK38L3.10695947
6EPHB13.02416189
7FGFR42.97005019
8MST42.84299884
9MUSK2.81974922
10LATS12.71267499
11STK242.70957945
12ACVR1B2.48687234
13JAK32.38636190
14NLK2.24885404
15STK392.19870033
16MAP3K122.17657597
17MST1R2.15004073
18IKBKE2.13230223
19ERN12.12207950
20MAP3K142.09292117
21STK102.04430896
22TYK21.99432829
23AKT31.98409595
24STK381.98343360
25INSRR1.98212362
26PTK2B1.97208773
27JAK11.94234349
28PRKD31.92943631
29TRPM71.92618691
30BMPR1B1.90963723
31MAPKAPK31.86469088
32EPHA21.83359412
33EPHA31.81334293
34GRK61.79233186
35NEK91.73554565
36LATS21.71499935
37DDR21.69913886
38DAPK21.69210607
39SIK11.65934811
40GRK11.62306972
41IRAK11.61208118
42PINK11.61193708
43MAP4K21.60337024
44TAOK31.60111847
45CASK1.55245871
46ZAP701.54792514
47WNK41.51734152
48MAPK151.49948455
49TBK11.48575793
50FGFR21.44479592
51CSK1.43376555
52PRKCQ1.39466904
53LIMK11.39390542
54MAP3K131.35059416
55PRKCH1.34646139
56HIPK21.34593029
57PRPF4B1.32198438
58TEC1.32065661
59PKN11.29929501
60TYRO31.27797913
61IRAK31.27151961
62LCK1.25175420
63STK31.21739165
64BTK1.21562461
65PDGFRA1.20886270
66MAP3K31.19439640
67PTK61.19403840
68FGFR31.19060507
69PIK3CA1.16878292
70BCKDK1.16668358
71PRKCE1.14928557
72IRAK41.14248681
73IKBKB1.08886904
74MET1.07914165
75PRKD21.07254860
76IRAK21.04587753
77ADRBK11.02379106
78JAK21.01489588
79MAP3K21.01162615
80PASK0.96229996
81NTRK10.93743942
82MAP2K10.93267598
83TRIB30.92192752
84TNIK0.89058833
85PDGFRB0.88832342
86ABL20.88387927
87OXSR10.88271287
88FLT30.87557341
89ADRBK20.86661372
90ROCK10.85750155
91FER0.85159961
92TGFBR10.85157363
93PHKG20.84317058
94PHKG10.84317058
95ERBB30.81939582
96MARK30.81674008
97PRKG20.81610600
98LRRK20.81113034
99MAP3K100.81013845
100CAMK2G0.79142438
101RIPK10.78008361
102CAMK2D0.77933571
103CHUK0.77610305
104FRK0.77352658
105HCK0.75991147
106NUAK10.73752424
107TESK10.72391427
108ERBB40.69821634
109ARAF0.67838989
110MAPKAPK50.66206796
111MAP2K20.66123043
112ILK0.65300217
113PTK20.64913322
114PAK30.64880425
115CLK10.63852832
116WNK10.63612803
117CAMK2A0.62996734
118EIF2AK30.62246699
119PIK3CG0.61643776
120MELK0.60858281
121MAPK70.59845969
122TESK20.59540761
123UHMK10.58966980
124PRKD10.57590018
125MAP3K70.56993947
126NTRK30.55502999
127INSR0.54611202
128CSNK1A1L0.53803127
129BRSK20.51801873
130GSK3A0.51358036
131CSNK1G10.49119488
132MAP2K60.49119195
133RPS6KA50.48315230
134MARK20.48119109
135PAK20.47872457
136CAMKK10.47645701
137SYK0.47434024
138BCR0.46791533
139IGF1R0.46636945
140MOS0.46137076
141PDK10.45383565
142PDK20.44786112
143LMTK20.44669003
144ROCK20.44157358
145NEK60.43946679
146FES0.43883738
147MAP3K10.43235887
148PIM20.42595163
149PRKCG0.41004169
150SGK20.40004125
151CAMK10.39613421
152SGK2230.39052987
153SGK4940.39052987
154CSNK1G30.39026178
155LYN0.38132946
156TGFBR20.37271037
157MAPK120.36372314
158ABL10.36289367
159MAP3K40.36203652
160FYN0.35904348
161DMPK0.35544587
162PAK40.35069883
163CAMK2B0.34577531
164PRKAA20.34129452
165DYRK1B0.30767479
166PDPK10.30459357
167FGFR10.29943545
168MAPK110.28558233

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.93784513
2Sulfur metabolism_Homo sapiens_hsa009203.14274141
3Primary immunodeficiency_Homo sapiens_hsa053403.12690609
4Protein export_Homo sapiens_hsa030602.82913832
5Steroid biosynthesis_Homo sapiens_hsa001002.51388030
6Fatty acid elongation_Homo sapiens_hsa000622.24933253
7Nitrogen metabolism_Homo sapiens_hsa009102.24811246
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.20878137
9T cell receptor signaling pathway_Homo sapiens_hsa046602.18889140
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09805972
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08507855
12Fatty acid degradation_Homo sapiens_hsa000711.90651449
13Mineral absorption_Homo sapiens_hsa049781.90360836
14ECM-receptor interaction_Homo sapiens_hsa045121.89711436
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88698631
16Circadian rhythm_Homo sapiens_hsa047101.88206394
17Tryptophan metabolism_Homo sapiens_hsa003801.78058871
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77715615
19Histidine metabolism_Homo sapiens_hsa003401.74149894
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60140164
21Fatty acid metabolism_Homo sapiens_hsa012121.59251843
22Fat digestion and absorption_Homo sapiens_hsa049751.54827821
23Butanoate metabolism_Homo sapiens_hsa006501.53830390
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.53615224
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52802704
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50044831
27Protein digestion and absorption_Homo sapiens_hsa049741.48608398
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43744984
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42844731
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40926824
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40168626
32Peroxisome_Homo sapiens_hsa041461.34827220
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.34271874
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33971636
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28509633
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27015256
37Folate biosynthesis_Homo sapiens_hsa007901.25685066
38Salivary secretion_Homo sapiens_hsa049701.23725232
39ABC transporters_Homo sapiens_hsa020101.23463489
40Propanoate metabolism_Homo sapiens_hsa006401.20974783
41Measles_Homo sapiens_hsa051621.19662512
42Antigen processing and presentation_Homo sapiens_hsa046121.14333552
43PPAR signaling pathway_Homo sapiens_hsa033201.11897160
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10871984
45Focal adhesion_Homo sapiens_hsa045101.09970323
46Graft-versus-host disease_Homo sapiens_hsa053321.06696938
47Gastric acid secretion_Homo sapiens_hsa049711.05708292
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05126759
49Dilated cardiomyopathy_Homo sapiens_hsa054141.05041988
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04679791
51Selenocompound metabolism_Homo sapiens_hsa004501.01093927
52Complement and coagulation cascades_Homo sapiens_hsa046101.00837751
53Glutathione metabolism_Homo sapiens_hsa004801.00770596
54Thyroid hormone synthesis_Homo sapiens_hsa049181.00751139
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99672679
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99584808
57Dorso-ventral axis formation_Homo sapiens_hsa043200.99107116
58B cell receptor signaling pathway_Homo sapiens_hsa046620.99049665
59Caffeine metabolism_Homo sapiens_hsa002320.98906069
60Chemical carcinogenesis_Homo sapiens_hsa052040.97109086
61Arachidonic acid metabolism_Homo sapiens_hsa005900.96507441
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.96201957
63Tight junction_Homo sapiens_hsa045300.95854229
64Glutamatergic synapse_Homo sapiens_hsa047240.95157172
65Osteoclast differentiation_Homo sapiens_hsa043800.94973704
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.94564133
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94179820
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93884383
69Renin secretion_Homo sapiens_hsa049240.92512618
70Arginine biosynthesis_Homo sapiens_hsa002200.91920710
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90367424
72Arginine and proline metabolism_Homo sapiens_hsa003300.88450655
73Ether lipid metabolism_Homo sapiens_hsa005650.87876783
74Vitamin B6 metabolism_Homo sapiens_hsa007500.86089724
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85778836
76Serotonergic synapse_Homo sapiens_hsa047260.84557495
77GABAergic synapse_Homo sapiens_hsa047270.83084338
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79958807
79Starch and sucrose metabolism_Homo sapiens_hsa005000.78726962
80Allograft rejection_Homo sapiens_hsa053300.78068108
81Glycerolipid metabolism_Homo sapiens_hsa005610.77675643
82Insulin resistance_Homo sapiens_hsa049310.77566856
83Phototransduction_Homo sapiens_hsa047440.75882496
84Ovarian steroidogenesis_Homo sapiens_hsa049130.75836973
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75748762
86Bile secretion_Homo sapiens_hsa049760.75663601
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74526961
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74458852
89Staphylococcus aureus infection_Homo sapiens_hsa051500.74098603
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73630630
91cAMP signaling pathway_Homo sapiens_hsa040240.73423435
92Nicotine addiction_Homo sapiens_hsa050330.72529285
93Calcium signaling pathway_Homo sapiens_hsa040200.72300488
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.72111365
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71911552
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71868419
97beta-Alanine metabolism_Homo sapiens_hsa004100.71374906
98Pancreatic secretion_Homo sapiens_hsa049720.71322687
99Phenylalanine metabolism_Homo sapiens_hsa003600.70454411
100Vitamin digestion and absorption_Homo sapiens_hsa049770.68610274
101Sphingolipid metabolism_Homo sapiens_hsa006000.68517075
102Autoimmune thyroid disease_Homo sapiens_hsa053200.67867895
103Hepatitis C_Homo sapiens_hsa051600.66998511
104Circadian entrainment_Homo sapiens_hsa047130.66828439
105Amphetamine addiction_Homo sapiens_hsa050310.66687480
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65244460
107Retinol metabolism_Homo sapiens_hsa008300.65179054
108Linoleic acid metabolism_Homo sapiens_hsa005910.65113295
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64449625
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64281446
111Type I diabetes mellitus_Homo sapiens_hsa049400.63525374
112Fatty acid biosynthesis_Homo sapiens_hsa000610.62197878
113Cocaine addiction_Homo sapiens_hsa050300.61210535
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61089948
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.60632252
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60604633
117Hippo signaling pathway_Homo sapiens_hsa043900.60391092
118Sulfur relay system_Homo sapiens_hsa041220.57959430
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.57951617
120Tyrosine metabolism_Homo sapiens_hsa003500.57936312
121Proteoglycans in cancer_Homo sapiens_hsa052050.56807095
122TNF signaling pathway_Homo sapiens_hsa046680.56392062
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.55816149
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54217237
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54143186
126Lysosome_Homo sapiens_hsa041420.53500621
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52691343
128Lysine degradation_Homo sapiens_hsa003100.52076541
129Amoebiasis_Homo sapiens_hsa051460.52064372
130TGF-beta signaling pathway_Homo sapiens_hsa043500.51397562
131Dopaminergic synapse_Homo sapiens_hsa047280.51068128
132Toxoplasmosis_Homo sapiens_hsa051450.49671205
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.49296996
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48557554
135Renin-angiotensin system_Homo sapiens_hsa046140.47736804
136Adherens junction_Homo sapiens_hsa045200.47515655
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46926341
138Oxytocin signaling pathway_Homo sapiens_hsa049210.46608354
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46552133
140Viral myocarditis_Homo sapiens_hsa054160.45662639
141Vibrio cholerae infection_Homo sapiens_hsa051100.45498065
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45496829
143Taste transduction_Homo sapiens_hsa047420.45027551
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42832266
145Chemokine signaling pathway_Homo sapiens_hsa040620.42594522
146Type II diabetes mellitus_Homo sapiens_hsa049300.41574061
147Pyruvate metabolism_Homo sapiens_hsa006200.40104413
148Prion diseases_Homo sapiens_hsa050200.40078376
149Acute myeloid leukemia_Homo sapiens_hsa052210.39770117
150Renal cell carcinoma_Homo sapiens_hsa052110.39584382
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35648686
152Hematopoietic cell lineage_Homo sapiens_hsa046400.34046401
153Insulin secretion_Homo sapiens_hsa049110.33868655
154Prolactin signaling pathway_Homo sapiens_hsa049170.32835746
155Other glycan degradation_Homo sapiens_hsa005110.31192915
156Prostate cancer_Homo sapiens_hsa052150.28617980
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.28592999

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