GRAMD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.17480966
2positive thymic T cell selection (GO:0045059)5.60569739
3regulation of gamma-delta T cell differentiation (GO:0045586)5.55136870
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.39496449
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.39496449
6antigen processing and presentation of endogenous antigen (GO:0019883)5.31782226
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19270162
8negative regulation of cell killing (GO:0031342)5.19270162
9negative thymic T cell selection (GO:0045060)4.99973822
10thymic T cell selection (GO:0045061)4.95429708
11negative T cell selection (GO:0043383)4.92127030
12regulation of gamma-delta T cell activation (GO:0046643)4.90292551
13positive T cell selection (GO:0043368)4.64707912
14T cell selection (GO:0045058)4.47555613
15positive regulation of histone deacetylation (GO:0031065)4.25623492
16mannose metabolic process (GO:0006013)4.23575239
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22579079
18response to interleukin-15 (GO:0070672)4.14875892
19regulation of interleukin-12 biosynthetic process (GO:0045075)4.06879093
20glycosphingolipid catabolic process (GO:0046479)3.77632828
21B cell receptor signaling pathway (GO:0050853)3.71194591
22natural killer cell differentiation (GO:0001779)3.63303548
23detection of other organism (GO:0098543)3.51321324
24complement activation, alternative pathway (GO:0006957)3.49789730
25response to peptidoglycan (GO:0032494)3.46491815
26interferon-gamma production (GO:0032609)3.43647007
27glycolipid catabolic process (GO:0019377)3.42305562
28cellular response to thyroid hormone stimulus (GO:0097067)3.37580108
29cellular response to interleukin-15 (GO:0071350)3.37495969
30detection of bacterium (GO:0016045)3.36891531
31regulation of leukocyte degranulation (GO:0043300)3.36481276
32negative regulation of erythrocyte differentiation (GO:0045647)3.34577971
33regulation of T cell tolerance induction (GO:0002664)3.32247192
34T cell receptor signaling pathway (GO:0050852)3.27673731
35oligosaccharide catabolic process (GO:0009313)3.27496264
36T cell costimulation (GO:0031295)3.26967559
37regulation of myeloid leukocyte mediated immunity (GO:0002886)3.22634128
38epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22313792
39regulation of B cell receptor signaling pathway (GO:0050855)3.22078354
40positive regulation of B cell differentiation (GO:0045579)3.21173455
41regulation of B cell differentiation (GO:0045577)3.19683249
42T cell migration (GO:0072678)3.19411751
43lymphocyte costimulation (GO:0031294)3.18817083
44protein localization to endosome (GO:0036010)3.17390017
45antigen receptor-mediated signaling pathway (GO:0050851)3.16966072
46phospholipid efflux (GO:0033700)3.15114739
47urea cycle (GO:0000050)3.14118455
48positive regulation of cellular amide metabolic process (GO:0034250)3.10248562
49response to muramyl dipeptide (GO:0032495)3.09329466
50urea metabolic process (GO:0019627)3.07370581
51detection of external biotic stimulus (GO:0098581)3.07334630
52response to thyroid hormone (GO:0097066)3.03809644
53positive regulation of protein deacetylation (GO:0090312)3.02641279
54macrophage activation involved in immune response (GO:0002281)3.01341248
55NIK/NF-kappaB signaling (GO:0038061)3.00021311
56regulation of mast cell degranulation (GO:0043304)2.99952426
57JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97110196
58neutrophil activation involved in immune response (GO:0002283)2.93539473
59positive regulation of lipoprotein lipase activity (GO:0051006)2.89895737
60positive regulation of triglyceride lipase activity (GO:0061365)2.89895737
61positive regulation by symbiont of host defense response (GO:0052509)2.89247393
62modulation by symbiont of host defense response (GO:0052031)2.89247393
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89247393
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89247393
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.89247393
66modulation by symbiont of host immune response (GO:0052553)2.89247393
67ceramide catabolic process (GO:0046514)2.89160827
68pinocytosis (GO:0006907)2.88608231
69detection of molecule of bacterial origin (GO:0032490)2.82816623
70negative regulation of phagocytosis (GO:0050765)2.82240144
71regulation of alpha-beta T cell proliferation (GO:0046640)2.80722852
72regulation of regulated secretory pathway (GO:1903305)2.79774495
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79140384
74positive regulation of tolerance induction (GO:0002645)2.78385570
75cytoskeletal anchoring at plasma membrane (GO:0007016)2.77155897
76nitrogen cycle metabolic process (GO:0071941)2.77007287
77T cell homeostasis (GO:0043029)2.76497355
78barbed-end actin filament capping (GO:0051016)2.73838640
79tolerance induction (GO:0002507)2.72672454
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71965570
81detection of biotic stimulus (GO:0009595)2.71616346
82antigen processing and presentation via MHC class Ib (GO:0002475)2.69904763
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68905852
84hepatocyte apoptotic process (GO:0097284)2.68147580
85positive regulation of leukocyte degranulation (GO:0043302)2.66498123
86negative regulation of T cell mediated immunity (GO:0002710)2.64890382
87leukocyte cell-cell adhesion (GO:0007159)2.64557369
88regulation of mast cell activation involved in immune response (GO:0033006)2.63925098
89germinal center formation (GO:0002467)2.63174060
90negative regulation of granulocyte differentiation (GO:0030853)2.62229039
91regulation of cholesterol esterification (GO:0010872)2.62018517
92response to laminar fluid shear stress (GO:0034616)2.60278031
93cortical actin cytoskeleton organization (GO:0030866)2.59703994
94Peyers patch development (GO:0048541)2.59444097
95mucosal-associated lymphoid tissue development (GO:0048537)2.59444097
96activation of JUN kinase activity (GO:0007257)2.59359161
97megakaryocyte development (GO:0035855)2.59259877
98cytoplasmic mRNA processing body assembly (GO:0033962)2.58424029
99regulation of isotype switching to IgG isotypes (GO:0048302)2.57391870
100regulation of cholesterol storage (GO:0010885)2.56969560
101lymphocyte homeostasis (GO:0002260)2.56861869
102negative regulation of myotube differentiation (GO:0010832)2.56814212
103angiotensin maturation (GO:0002003)2.56713012
104leukocyte aggregation (GO:0070486)2.55130016
105negative regulation of interleukin-12 production (GO:0032695)2.54380201
106positive regulation of phagocytosis (GO:0050766)2.53868364
107positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53654915
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.53622284
109natural killer cell activation (GO:0030101)2.53139369
110peptide catabolic process (GO:0043171)2.52439437
111positive regulation of isotype switching (GO:0045830)2.51613117
112immune response-activating cell surface receptor signaling pathway (GO:0002429)2.51133509
113positive regulation of cholesterol efflux (GO:0010875)2.48920444
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48461481
115positive regulation of Rap GTPase activity (GO:0032854)2.47568224
116germ cell migration (GO:0008354)2.47466501
117positive regulation of interleukin-2 production (GO:0032743)2.46545072
118regulation of superoxide anion generation (GO:0032928)2.44757720
119heterotypic cell-cell adhesion (GO:0034113)2.44581053
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.43507398
121cellular extravasation (GO:0045123)2.43301637
122peptidyl-lysine dimethylation (GO:0018027)2.42948650
123regulation of response to interferon-gamma (GO:0060330)2.42089540
124serine transport (GO:0032329)2.41776223
125glial cell proliferation (GO:0014009)2.41150017
126regulation of macrophage chemotaxis (GO:0010758)2.40781622
127amino sugar catabolic process (GO:0046348)2.40137245
128growth hormone receptor signaling pathway (GO:0060396)2.39329480
129positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.37649898
130negative regulation of cell size (GO:0045792)2.37091662
131regulation of early endosome to late endosome transport (GO:2000641)2.37068476
132sodium ion export (GO:0071436)2.36832640
133regulation of cholesterol homeostasis (GO:2000188)2.36762296
134regulation of phagocytosis (GO:0050764)2.36433111
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.36116735
136regulation of natural killer cell mediated immunity (GO:0002715)2.36116735
137regulation of regulatory T cell differentiation (GO:0045589)2.35622212
138regulation of T cell receptor signaling pathway (GO:0050856)2.34671193
139positive regulation of mast cell activation involved in immune response (GO:0033008)2.34037960
140positive regulation of mast cell degranulation (GO:0043306)2.34037960
141cellular response to zinc ion (GO:0071294)2.33349226
142negative regulation of sterol transport (GO:0032372)2.32633707
143negative regulation of cholesterol transport (GO:0032375)2.32633707
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32369139
145complement activation (GO:0006956)2.31389689
146positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31133263
147positive regulation of regulated secretory pathway (GO:1903307)2.30783203
148regulation of histone deacetylation (GO:0031063)2.29521806
149myeloid dendritic cell activation (GO:0001773)2.29149015
150lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29044387
151positive regulation of lamellipodium assembly (GO:0010592)2.28711197
152negative regulation of histone methylation (GO:0031061)2.28270574
153B cell homeostasis (GO:0001782)2.28011880
154epoxygenase P450 pathway (GO:0019373)2.27725120
155regulation of tolerance induction (GO:0002643)2.27586632
156leukocyte tethering or rolling (GO:0050901)2.27344789
157positive regulation of fatty acid biosynthetic process (GO:0045723)2.26719645
158establishment of endothelial barrier (GO:0061028)2.26425856
159regulation of ARF protein signal transduction (GO:0032012)2.25802825
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25550169
161regulation of ARF GTPase activity (GO:0032312)2.24982502
162adherens junction assembly (GO:0034333)2.24461709
163regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.23433902
164regulation of monocyte differentiation (GO:0045655)2.23380747
165myeloid dendritic cell differentiation (GO:0043011)2.22335726
166cell-substrate junction assembly (GO:0007044)2.22137357
167positive regulation of lipid catabolic process (GO:0050996)2.22089151
168positive regulation of receptor recycling (GO:0001921)2.22084206
169stress fiber assembly (GO:0043149)2.21732791
170low-density lipoprotein particle remodeling (GO:0034374)2.21593244
171embryonic hemopoiesis (GO:0035162)2.21479966
172regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.21069382
173glucose 6-phosphate metabolic process (GO:0051156)2.20644167
174N-acetylneuraminate metabolic process (GO:0006054)2.20512186
175T cell proliferation (GO:0042098)2.20350601
176Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.19832053
177Fc-gamma receptor signaling pathway (GO:0038094)2.19832053
178apoptotic process involved in morphogenesis (GO:0060561)2.19808392
179immunoglobulin mediated immune response (GO:0016064)2.19737973
180positive regulation of mast cell activation (GO:0033005)2.19376763
181protein-lipid complex assembly (GO:0065005)2.18422814
182negative regulation of toll-like receptor signaling pathway (GO:0034122)2.18290797
183regulation of apoptotic cell clearance (GO:2000425)2.18216054
184plasma lipoprotein particle assembly (GO:0034377)2.17541049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.48612221
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.47778991
3MYC_22102868_ChIP-Seq_BL_Human4.44647362
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.84206754
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.33540890
6VDR_21846776_ChIP-Seq_THP-1_Human3.11992506
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.93553140
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.90235604
9* KDM2B_26808549_Chip-Seq_DND41_Human2.84586927
10* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.68513600
11RUNX_20019798_ChIP-Seq_JUKART_Human2.67749189
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.64267852
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.64101188
14MAF_26560356_Chip-Seq_TH1_Human2.63056323
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.52697518
16UTX_26944678_Chip-Seq_JUKART_Human2.42773523
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33388721
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23036792
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22423267
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.22335162
21MYB_26560356_Chip-Seq_TH2_Human2.22187351
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.22063158
23SCL_19346495_ChIP-Seq_HPC-7_Human2.12266469
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.11283461
25* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08910402
26E2F7_22180533_ChIP-Seq_HELA_Human2.06850977
27VDR_24763502_ChIP-Seq_THP-1_Human2.05697831
28KDM2B_26808549_Chip-Seq_JURKAT_Human2.04501343
29MYB_26560356_Chip-Seq_TH1_Human1.93979568
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91905945
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.81794761
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.79523648
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.76951935
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76410611
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75385823
36LXR_22292898_ChIP-Seq_THP-1_Human1.72617860
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72560864
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72187181
39SPI1_23127762_ChIP-Seq_K562_Human1.70900757
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64912500
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63935383
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63221669
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62102939
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59882642
45MAF_26560356_Chip-Seq_TH2_Human1.59640901
46KDM2B_26808549_Chip-Seq_K562_Human1.58583195
47* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58262893
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.57974854
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55906454
50GATA1_22025678_ChIP-Seq_K562_Human1.53896877
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49114852
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49104466
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48649979
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.47278793
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46074280
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43137386
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41611055
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41418913
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40528560
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40399777
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40189061
62CLOCK_20551151_ChIP-Seq_293T_Human1.39898001
63GATA3_27048872_Chip-Seq_THYMUS_Human1.39182845
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38242110
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37218380
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36760699
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35192713
68RACK7_27058665_Chip-Seq_MCF-7_Human1.33906115
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.33841334
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.32538818
71GATA1_19941826_ChIP-Seq_K562_Human1.32317058
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.31904609
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31562681
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30739657
75NCOR1_26117541_ChIP-Seq_K562_Human1.30022786
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27561326
77CIITA_25753668_ChIP-Seq_RAJI_Human1.26988152
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24839015
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24304265
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.24279607
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.22818942
82SMC4_20622854_ChIP-Seq_HELA_Human1.22044652
83ZNF263_19887448_ChIP-Seq_K562_Human1.21424105
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20297999
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19161068
86VDR_24787735_ChIP-Seq_THP-1_Human1.18330725
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18322447
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17007997
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16283792
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15997103
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.15112168
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.15112168
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13968443
94* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13607193
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12639339
96SPI1_23547873_ChIP-Seq_NB4_Human1.12348713
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11144819
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10854843
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.10418239
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10157019
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09110368
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08975124
103BCOR_27268052_Chip-Seq_Bcells_Human1.08217515
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07897042
105* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06001894
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05890187
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.05756775
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05510722
109ATF3_27146783_Chip-Seq_COLON_Human1.04684155
110* GATA2_19941826_ChIP-Seq_K562_Human1.04088059
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03234609
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02124594
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01860882
114* DROSHA_22980978_ChIP-Seq_HELA_Human1.01474557
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00677741
116* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00111808
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96556337
118CREB1_26743006_Chip-Seq_LNCaP_Human0.95855828
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95261342
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.94973386
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93900864
122SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.93413666
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.92484880
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90735076
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.90481427
126P68_20966046_ChIP-Seq_HELA_Human0.90063067
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88539374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.39401634
2MP0003763_abnormal_thymus_physiology3.37757788
3MP0000685_abnormal_immune_system3.34924129
4MP0003300_gastrointestinal_ulcer3.33286454
5MP0002139_abnormal_hepatobiliary_system3.27946202
6MP0009840_abnormal_foam_cell3.16913304
7MP0003172_abnormal_lysosome_physiology3.15115316
8MP0003191_abnormal_cellular_cholesterol3.03752694
9MP0003303_peritoneal_inflammation2.87261824
10MP0003705_abnormal_hypodermis_morpholog2.63346527
11MP0001873_stomach_inflammation2.61980715
12MP0002396_abnormal_hematopoietic_system2.56909666
13MP0001800_abnormal_humoral_immune2.52645394
14MP0010352_gastrointestinal_tract_polyps2.51988168
15MP0001835_abnormal_antigen_presentation2.43209058
16MP0005451_abnormal_body_composition2.40327547
17MP0002166_altered_tumor_susceptibility2.38509359
18MP0004510_myositis2.37363354
19MP0005387_immune_system_phenotype2.35504745
20MP0001790_abnormal_immune_system2.35504745
21MP0008961_abnormal_basal_metabolism2.30610082
22MP0000604_amyloidosis2.27860512
23MP0005671_abnormal_response_to2.25248399
24MP0002398_abnormal_bone_marrow2.21847248
25MP0010234_abnormal_vibrissa_follicle2.10490285
26MP0004808_abnormal_hematopoietic_stem2.07925769
27MP0005360_urolithiasis2.06586379
28MP0000703_abnormal_thymus_morphology2.05011337
29MP0002420_abnormal_adaptive_immunity2.04113069
30MP0005409_darkened_coat_color2.03715369
31MP0005076_abnormal_cell_differentiation2.01942527
32MP0001819_abnormal_immune_cell2.01048015
33MP0002452_abnormal_antigen_presenting2.00216730
34MP0003329_amyloid_beta_deposits1.98437890
35MP0003866_abnormal_defecation1.96667159
36MP0004947_skin_inflammation1.89550208
37MP0009278_abnormal_bone_marrow1.88674582
38MP0005365_abnormal_bile_salt1.87265079
39MP0002006_tumorigenesis1.80951547
40MP0002723_abnormal_immune_serum1.80650102
41MP0000716_abnormal_immune_system1.79708654
42MP0003690_abnormal_glial_cell1.79205360
43MP0008260_abnormal_autophagy1.79019665
44MP0006054_spinal_hemorrhage1.76805064
45MP0005000_abnormal_immune_tolerance1.76450368
46MP0002722_abnormal_immune_system1.75980260
47MP0010155_abnormal_intestine_physiology1.75585051
48MP0003724_increased_susceptibility_to1.64636827
49MP0004185_abnormal_adipocyte_glucose1.63306500
50MP0000689_abnormal_spleen_morphology1.61008944
51MP0003566_abnormal_cell_adhesion1.58624936
52MP0002254_reproductive_system_inflammat1.54805921
53MP0003045_fibrosis1.51212185
54MP0003075_altered_response_to1.49118277
55MP0003279_aneurysm1.48984101
56MP0002429_abnormal_blood_cell1.48336900
57MP0002405_respiratory_system_inflammati1.45132046
58MP0003091_abnormal_cell_migration1.44503635
59MP0003436_decreased_susceptibility_to1.43221773
60MP0001348_abnormal_lacrimal_gland1.43212947
61MP0005464_abnormal_platelet_physiology1.38508465
62MP0005025_abnormal_response_to1.31951512
63MP0005397_hematopoietic_system_phenotyp1.31939251
64MP0001545_abnormal_hematopoietic_system1.31939251
65MP0004381_abnormal_hair_follicle1.29878215
66MP0002877_abnormal_melanocyte_morpholog1.28869952
67MP0009333_abnormal_splenocyte_physiolog1.28836162
68MP0004264_abnormal_extraembryonic_tissu1.28665777
69MP0000733_abnormal_muscle_development1.24921380
70MP0001853_heart_inflammation1.22834389
71MP0004130_abnormal_muscle_cell1.21629979
72MP0000490_abnormal_crypts_of1.19099832
73MP0000465_gastrointestinal_hemorrhage1.16710552
74MP0005085_abnormal_gallbladder_physiolo1.16593921
75MP0005166_decreased_susceptibility_to1.15291598
76MP0004084_abnormal_cardiac_muscle1.12658155
77MP0000858_altered_metastatic_potential1.12204546
78MP0000343_altered_response_to1.10365612
79MP0002933_joint_inflammation1.09801947
80MP0005666_abnormal_adipose_tissue1.08022923
81MP0010630_abnormal_cardiac_muscle1.06964254
82MP0002971_abnormal_brown_adipose1.06512890
83MP0008469_abnormal_protein_level1.05336842
84MP0004858_abnormal_nervous_system1.03946863
85MP0000751_myopathy1.03454455
86MP0005375_adipose_tissue_phenotype1.00829575
87MP0003453_abnormal_keratinocyte_physiol1.00623871
88MP0005670_abnormal_white_adipose0.99850636
89MP0003448_altered_tumor_morphology0.99281324
90MP0010329_abnormal_lipoprotein_level0.98929512
91MP0002138_abnormal_hepatobiliary_system0.97191306
92MP0000569_abnormal_digit_pigmentation0.96270399
93MP0004087_abnormal_muscle_fiber0.96000473
94MP0001845_abnormal_inflammatory_respons0.95990463
95MP0005623_abnormal_meninges_morphology0.95799430
96MP0000609_abnormal_liver_physiology0.94213377
97MP0002419_abnormal_innate_immunity0.94146058
98MP0004782_abnormal_surfactant_physiolog0.93782140
99MP0001666_abnormal_nutrient_absorption0.92583190
100MP0005023_abnormal_wound_healing0.92009279
101MP0003879_abnormal_hair_cell0.89791468
102MP0000920_abnormal_myelination0.89127316
103MP0005310_abnormal_salivary_gland0.88588056
104MP0008770_decreased_survivor_rate0.88292338
105MP0001851_eye_inflammation0.87780767
106MP0000015_abnormal_ear_pigmentation0.86830562
107MP0009115_abnormal_fat_cell0.86025115
108MP0000747_muscle_weakness0.84647413
109MP0009785_altered_susceptibility_to0.83546925
110MP0002118_abnormal_lipid_homeostasis0.83238554
111MP0000003_abnormal_adipose_tissue0.82997961
112MP0002019_abnormal_tumor_incidence0.82955064
113MP0003634_abnormal_glial_cell0.82575077
114MP0006082_CNS_inflammation0.81579920
115MP0002089_abnormal_postnatal_growth/wei0.79682452
116MP0003828_pulmonary_edema0.78138617
117MP0010307_abnormal_tumor_latency0.77768217
118MP0001958_emphysema0.77195509
119MP0001784_abnormal_fluid_regulation0.75715783
120MP0005501_abnormal_skin_physiology0.73734040
121MP0004019_abnormal_vitamin_homeostasis0.73423782
122MP0002925_abnormal_cardiovascular_devel0.72893757
123MP0000477_abnormal_intestine_morphology0.72564049
124MP0005381_digestive/alimentary_phenotyp0.72018062
125MP0008569_lethality_at_weaning0.71689137
126MP0009764_decreased_sensitivity_to0.71619933
127MP0003183_abnormal_peptide_metabolism0.71013633
128MP0002148_abnormal_hypersensitivity_rea0.69908053
129MP0001663_abnormal_digestive_system0.69681949
130MP0004859_abnormal_synaptic_plasticity0.69046352
131MP0002796_impaired_skin_barrier0.67924815
132MP0001849_ear_inflammation0.67509213
133MP0002998_abnormal_bone_remodeling0.66835391
134MP0002128_abnormal_blood_circulation0.62148685
135MP0001533_abnormal_skeleton_physiology0.62116495
136MP0001216_abnormal_epidermal_layer0.61598444
137MP0002009_preneoplasia0.60773669
138MP0000266_abnormal_heart_morphology0.60061059
139MP0001544_abnormal_cardiovascular_syste0.58348330

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.36836290
2Abnormality of liposaccharide metabolism (HP:0010968)4.36836290
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.36836290
4Systemic lupus erythematosus (HP:0002725)4.36771791
5Increased cerebral lipofuscin (HP:0011813)4.15013262
6Dysostosis multiplex (HP:0000943)3.66832043
7Complement deficiency (HP:0004431)3.62820593
8Verrucae (HP:0200043)3.57969907
9Papilloma (HP:0012740)3.57969907
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.47196808
11Agammaglobulinemia (HP:0004432)3.46567658
12Vacuolated lymphocytes (HP:0001922)3.45280929
13Recurrent gram-negative bacterial infections (HP:0005420)3.43107670
14Hyperacusis (HP:0010780)3.38422949
15Recurrent bronchitis (HP:0002837)3.36336042
16Abnormality of the fingertips (HP:0001211)3.34963003
17Abnormality of complement system (HP:0005339)3.34246660
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.33367356
19T lymphocytopenia (HP:0005403)3.31058690
20Abnormality of macrophages (HP:0004311)3.26320729
21Panhypogammaglobulinemia (HP:0003139)3.19155880
22Glomerulonephritis (HP:0000099)3.18208588
23Neurofibrillary tangles (HP:0002185)3.17031741
24Chronic otitis media (HP:0000389)3.16980833
25Recurrent abscess formation (HP:0002722)3.15594701
26Cellulitis (HP:0100658)3.15059218
27Nasal polyposis (HP:0100582)3.09336262
28Abnormality of T cell number (HP:0011839)3.07065056
29Inflammation of the large intestine (HP:0002037)3.06364873
30Gastrointestinal inflammation (HP:0004386)3.04299652
31Increased density of long bones (HP:0006392)3.00706788
32Recurrent viral infections (HP:0004429)3.00653295
33Recurrent bacterial skin infections (HP:0005406)2.98466427
34Deep venous thrombosis (HP:0002625)2.97039440
35Loss of speech (HP:0002371)2.96684887
36Colitis (HP:0002583)2.92843381
37Mucopolysacchariduria (HP:0008155)2.90994147
38Urinary glycosaminoglycan excretion (HP:0003541)2.90994147
39Vertebral arch anomaly (HP:0008438)2.88982145
40Abnormality of polysaccharide metabolism (HP:0011012)2.84444912
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.84444912
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.84444912
43Aortic aneurysm (HP:0004942)2.82651192
44Cerebral aneurysm (HP:0004944)2.80361444
45Recurrent fungal infections (HP:0002841)2.76884631
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72724984
47Abnormality of the nasal mucosa (HP:0000433)2.70791645
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70603786
49Increased IgE level (HP:0003212)2.65276417
50Recurrent cutaneous fungal infections (HP:0011370)2.62196638
51Chronic mucocutaneous candidiasis (HP:0002728)2.62196638
52Cerebral inclusion bodies (HP:0100314)2.58037086
53Macroorchidism (HP:0000053)2.56588512
54Gingivitis (HP:0000230)2.55536971
55Hemorrhage of the eye (HP:0011885)2.46965405
56Amyloidosis (HP:0011034)2.44687051
57Elevated erythrocyte sedimentation rate (HP:0003565)2.43504240
58Axonal loss (HP:0003447)2.41386095
59Mediastinal lymphadenopathy (HP:0100721)2.39376160
60Abnormality of T cells (HP:0002843)2.39220124
61Thrombocytosis (HP:0001894)2.35558541
62IgM deficiency (HP:0002850)2.33481938
63Thoracic kyphosis (HP:0002942)2.31261729
64Purpura (HP:0000979)2.31245036
65Frequent falls (HP:0002359)2.27293332
66Broad metatarsal (HP:0001783)2.26909414
67Malnutrition (HP:0004395)2.26868374
68Neuronal loss in central nervous system (HP:0002529)2.25803764
69Myocardial infarction (HP:0001658)2.21799242
70Viral hepatitis (HP:0006562)2.20233935
71Abnormality of oral frenula (HP:0000190)2.19742745
72Meningitis (HP:0001287)2.19301238
73Dilatation of the ascending aorta (HP:0005111)2.17000217
74Chronic obstructive pulmonary disease (HP:0006510)2.16810784
75Obstructive lung disease (HP:0006536)2.16810784
76Hematochezia (HP:0002573)2.16798339
77Xanthomatosis (HP:0000991)2.16583949
78Asymmetric septal hypertrophy (HP:0001670)2.15972869
79Abnormal platelet volume (HP:0011876)2.15216763
80Disinhibition (HP:0000734)2.14440449
81Emphysema (HP:0002097)2.14041874
82Pustule (HP:0200039)2.13399778
83Abnormality of the thoracic spine (HP:0100711)2.12265343
84Mitral valve prolapse (HP:0001634)2.09520961
85Rectal prolapse (HP:0002035)2.08521203
86Short 4th metacarpal (HP:0010044)2.05759161
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05759161
88Subacute progressive viral hepatitis (HP:0006572)2.05655324
89Polygenic inheritance (HP:0010982)1.99618147
90Orchitis (HP:0100796)1.99617714
91Bicuspid aortic valve (HP:0001647)1.98481095
92Chest pain (HP:0100749)1.97567743
93Shallow orbits (HP:0000586)1.97006599
94Apathy (HP:0000741)1.96715657
95Hemiplegia (HP:0002301)1.96516005
96Interstitial pulmonary disease (HP:0006530)1.95373099
97Flat acetabular roof (HP:0003180)1.95361703
98Distal lower limb amyotrophy (HP:0008944)1.95008183
99Thin bony cortex (HP:0002753)1.94400618
100Pointed chin (HP:0000307)1.94204485
101Mitral regurgitation (HP:0001653)1.94041245
102Dysmetric saccades (HP:0000641)1.93501882
103Joint hemorrhage (HP:0005261)1.92783533
104Segmental peripheral demyelination/remyelination (HP:0003481)1.92694247
105Bone pain (HP:0002653)1.91936236
106Lower limb amyotrophy (HP:0007210)1.91394816
107Polycythemia (HP:0001901)1.91219632
108Nephritis (HP:0000123)1.91043864
109Diminished motivation (HP:0000745)1.90095173
110Recurrent skin infections (HP:0001581)1.89648080
111J-shaped sella turcica (HP:0002680)1.89432723
112Elfin facies (HP:0004428)1.88459289
113Peripheral demyelination (HP:0011096)1.87927219
114Basal cell carcinoma (HP:0002671)1.87819054
115Obstructive sleep apnea (HP:0002870)1.86549111
116Persistence of primary teeth (HP:0006335)1.86377316
117Insomnia (HP:0100785)1.85493986
118Increased serum ferritin (HP:0003281)1.85359708
119Increased mean platelet volume (HP:0011877)1.85149270
120Prolonged bleeding time (HP:0003010)1.84812475
121Ulnar bowing (HP:0003031)1.84357400
122Myositis (HP:0100614)1.82989449
123Pathologic fracture (HP:0002756)1.82937746
124Lymphopenia (HP:0001888)1.82844735
125Aneurysm (HP:0002617)1.82743714
126Thyroiditis (HP:0100646)1.80784823
127Difficulty running (HP:0009046)1.80529526
128Distal lower limb muscle weakness (HP:0009053)1.80160596
129Enlarged penis (HP:0000040)1.79277590
130Hypercortisolism (HP:0001578)1.78120278
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.77320822
132Cardiomegaly (HP:0001640)1.76777508
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76349307
134Abnormality of the periventricular white matter (HP:0002518)1.76171166
135Spontaneous hematomas (HP:0007420)1.75983769
136Striae distensae (HP:0001065)1.75134617
137Mutism (HP:0002300)1.74961381
138Supranuclear gaze palsy (HP:0000605)1.74912662
139Protrusio acetabuli (HP:0003179)1.74819868
140Nuclear cataract (HP:0100018)1.74782568
141Gingival bleeding (HP:0000225)1.74727424
142Radial bowing (HP:0002986)1.74509005
143Abnormality of B cell number (HP:0010975)1.73781976
144B lymphocytopenia (HP:0010976)1.73781976
145Gastrointestinal stroma tumor (HP:0100723)1.73729260
146Epistaxis (HP:0000421)1.73500051
147Heterotopia (HP:0002282)1.73137243
148Upper motor neuron abnormality (HP:0002127)1.72869360
149Arterial thrombosis (HP:0004420)1.72488829
150Eczematoid dermatitis (HP:0000976)1.72067899
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.71774632
152Papilledema (HP:0001085)1.71566819
153Chronic sinusitis (HP:0011109)1.70808631
154Onion bulb formation (HP:0003383)1.70021232
155Broad face (HP:0000283)1.68818189
156Hyporeflexia of lower limbs (HP:0002600)1.68370368
157Hepatosplenomegaly (HP:0001433)1.68336488
158Arterial tortuosity (HP:0005116)1.66783336
159Abdominal distention (HP:0003270)1.66193233
160Abnormality of the gastric mucosa (HP:0004295)1.65718135
161Syringomyelia (HP:0003396)1.65698856
162Spinal cord lesions (HP:0100561)1.65698856
163Bowel diverticulosis (HP:0005222)1.65422694
164Pulmonary embolism (HP:0002204)1.65032550
165Fatigue (HP:0012378)1.64792371
166Abnormality of T cell physiology (HP:0011840)1.64402261
167Vertebral compression fractures (HP:0002953)1.64348959
168Dementia (HP:0000726)1.64282310
169Abnormality of the lumbar spine (HP:0100712)1.63984246
170Visceral angiomatosis (HP:0100761)1.63482963
171Osteomyelitis (HP:0002754)1.62481263
172Bowed forearm bones (HP:0003956)1.62329372
173Bowing of the arm (HP:0006488)1.62329372
174Aortic dissection (HP:0002647)1.62248294
175Hypertriglyceridemia (HP:0002155)1.62112191
176Broad palm (HP:0001169)1.61636282
177Combined immunodeficiency (HP:0005387)1.61595650
178Aortic regurgitation (HP:0001659)1.61021723
179Ankle contracture (HP:0006466)1.60593047
180Narrow palate (HP:0000189)1.59878152
181Personality changes (HP:0000751)1.58703583
182Retrobulbar optic neuritis (HP:0100654)1.58685313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.43336831
2MAP3K104.37914630
3TRIB34.12391623
4MAP4K13.93817432
5EEF2K3.75293115
6PKN23.61260164
7RIPK42.60325548
8TTN2.45005487
9GRK62.22681299
10LRRK22.14417476
11STK102.13099153
12SIK21.95527828
13SMG11.83844772
14JAK31.82475874
15ICK1.80448191
16FGFR41.75017013
17ITK1.73237202
18IRAK31.73160696
19PTK61.72736157
20MAP3K71.66290921
21FGFR31.59914652
22TAOK11.49990198
23CDK121.45007819
24JAK11.44452266
25TAOK21.42642885
26TYK21.41297707
27MAP3K131.34455464
28RIPK11.33823977
29ZAP701.33263311
30MAP3K11.30208429
31SIK11.28673096
32ERN11.24317265
33MAP3K31.18158951
34HCK1.17596680
35PDPK11.16903294
36BTK1.13764056
37EPHB11.10508173
38PRKCH1.09733784
39MAP3K111.09694557
40PDGFRA1.07137350
41ALK1.06228056
42DMPK1.06105565
43MARK21.05027172
44MAP3K61.04561814
45TYRO31.03666974
46TXK1.02650250
47RET1.02211100
48SYK1.02090939
49TBK10.95410599
50MATK0.94952510
51MAP3K140.93307145
52IRAK40.90434741
53RPS6KA40.90430526
54HIPK20.88507758
55MAP3K20.87967487
56LCK0.86814676
57CSK0.86460610
58RPS6KC10.85580096
59RPS6KL10.85580096
60LMTK20.84585040
61STK110.83124721
62DDR20.82216512
63PRKD20.81465618
64SCYL20.80450867
65PDGFRB0.80410108
66BLK0.79449542
67JAK20.77885806
68CDK40.76055617
69RPS6KB20.75959594
70MARK30.75652064
71PRKD10.75265213
72TNK20.74699824
73CDK90.72834932
74MAPK70.72434037
75FGFR20.71532735
76TGFBR20.70967851
77CAMK1D0.70665969
78NME20.70596882
79MAP2K20.69970723
80FGR0.69843050
81PIM10.69771959
82IKBKE0.69297440
83STK240.68933461
84MAPK110.68452317
85NEK20.67547361
86MAP2K60.66623028
87CSF1R0.66128303
88CAMKK10.65834284
89NLK0.65720021
90CAMK1G0.65542968
91CDK60.63863224
92BMX0.63829042
93RPS6KA60.63304233
94IRAK20.63007889
95FLT30.62539816
96FES0.62267772
97PDK10.61919600
98CHUK0.61276449
99MAP3K80.60754860
100MTOR0.57967911
101PRKCQ0.55839780
102MAP2K30.55414933
103LYN0.54987040
104EPHA30.54751940
105MAPK40.52796852
106KIT0.52425876
107PRKG20.51345530
108CLK10.51257351
109IKBKB0.50330720
110DYRK1B0.49993724
111ILK0.48918968
112KSR20.47850649
113MAPK120.46699618
114PAK20.46360096
115CDC42BPA0.46007390
116SGK30.45444352
117MST1R0.45433324
118PRKAA20.44395853
119TEC0.44395410
120TESK20.44279147
121TGFBR10.43676105
122FGFR10.43017751
123PRKD30.42704091
124MAPKAPK30.41785759
125MELK0.41305361
126STK40.40632645
127MAP2K40.40435931
128YES10.38752651
129MAP3K90.38406431
130PTK20.38115183
131TRPM70.36997897
132CAMK40.36552424
133PAK60.35597757
134FYN0.35316106
135RPS6KA20.35240972
136RPS6KA10.34323824

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.13641836
2Primary immunodeficiency_Homo sapiens_hsa053403.05966816
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72083339
4Staphylococcus aureus infection_Homo sapiens_hsa051502.44228856
5B cell receptor signaling pathway_Homo sapiens_hsa046622.38223684
6T cell receptor signaling pathway_Homo sapiens_hsa046602.09730018
7Lysosome_Homo sapiens_hsa041421.92780674
8Chronic myeloid leukemia_Homo sapiens_hsa052201.92463500
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.92311608
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86517549
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78638107
12Osteoclast differentiation_Homo sapiens_hsa043801.74222278
13Complement and coagulation cascades_Homo sapiens_hsa046101.67374659
14Prion diseases_Homo sapiens_hsa050201.65141094
15Viral myocarditis_Homo sapiens_hsa054161.61880926
16Antigen processing and presentation_Homo sapiens_hsa046121.61361962
17Acute myeloid leukemia_Homo sapiens_hsa052211.59084500
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53773389
19Pancreatic cancer_Homo sapiens_hsa052121.48821497
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.45187635
21Non-small cell lung cancer_Homo sapiens_hsa052231.44127266
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.43678816
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43486624
24Toxoplasmosis_Homo sapiens_hsa051451.41006652
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40168434
26Platelet activation_Homo sapiens_hsa046111.40091344
27Measles_Homo sapiens_hsa051621.36983604
28VEGF signaling pathway_Homo sapiens_hsa043701.36463452
29Colorectal cancer_Homo sapiens_hsa052101.35366410
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.33438500
31mTOR signaling pathway_Homo sapiens_hsa041501.30262459
32Leishmaniasis_Homo sapiens_hsa051401.28330820
33Small cell lung cancer_Homo sapiens_hsa052221.26852295
34Chemokine signaling pathway_Homo sapiens_hsa040621.24443414
35Endometrial cancer_Homo sapiens_hsa052131.19714646
36Pertussis_Homo sapiens_hsa051331.15347132
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.14679348
38Glioma_Homo sapiens_hsa052141.13421833
39PPAR signaling pathway_Homo sapiens_hsa033201.12960468
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.12620949
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10838949
42Proteoglycans in cancer_Homo sapiens_hsa052051.09575115
43Graft-versus-host disease_Homo sapiens_hsa053321.09372800
44Hepatitis B_Homo sapiens_hsa051611.08124779
45HTLV-I infection_Homo sapiens_hsa051661.07960530
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.07395785
47Focal adhesion_Homo sapiens_hsa045101.07128613
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05879477
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04316709
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02849964
51Bile secretion_Homo sapiens_hsa049761.02434102
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02285808
53Insulin resistance_Homo sapiens_hsa049311.01178221
54Arginine biosynthesis_Homo sapiens_hsa002201.01144885
55Apoptosis_Homo sapiens_hsa042101.00140875
56TNF signaling pathway_Homo sapiens_hsa046680.99249916
57Prolactin signaling pathway_Homo sapiens_hsa049170.98346769
58Dilated cardiomyopathy_Homo sapiens_hsa054140.97142073
59MicroRNAs in cancer_Homo sapiens_hsa052060.96880068
60Shigellosis_Homo sapiens_hsa051310.96484652
61Hematopoietic cell lineage_Homo sapiens_hsa046400.96340460
62Type II diabetes mellitus_Homo sapiens_hsa049300.96063606
63Notch signaling pathway_Homo sapiens_hsa043300.93388681
64Phagosome_Homo sapiens_hsa041450.92853831
65Gastric acid secretion_Homo sapiens_hsa049710.90896506
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90741998
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.90114638
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88929509
69Viral carcinogenesis_Homo sapiens_hsa052030.88206106
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.88197488
71Adherens junction_Homo sapiens_hsa045200.87744654
72Fructose and mannose metabolism_Homo sapiens_hsa000510.87459798
73Galactose metabolism_Homo sapiens_hsa000520.87140626
74Renal cell carcinoma_Homo sapiens_hsa052110.86902129
75Asthma_Homo sapiens_hsa053100.86238830
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86226234
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83814064
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83670761
79FoxO signaling pathway_Homo sapiens_hsa040680.82407023
80Hepatitis C_Homo sapiens_hsa051600.82372949
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82005463
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81336033
83Estrogen signaling pathway_Homo sapiens_hsa049150.80518189
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.79821067
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79401475
86MAPK signaling pathway_Homo sapiens_hsa040100.79298225
87ErbB signaling pathway_Homo sapiens_hsa040120.78747356
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78274463
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77312706
90Histidine metabolism_Homo sapiens_hsa003400.76638806
91Oxytocin signaling pathway_Homo sapiens_hsa049210.76598230
92Endocytosis_Homo sapiens_hsa041440.76422042
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76231536
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76017817
95HIF-1 signaling pathway_Homo sapiens_hsa040660.75352381
96Insulin signaling pathway_Homo sapiens_hsa049100.75180736
97Rap1 signaling pathway_Homo sapiens_hsa040150.74889225
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74275353
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74087691
100Dorso-ventral axis formation_Homo sapiens_hsa043200.73948508
101Tuberculosis_Homo sapiens_hsa051520.73528873
102Lysine degradation_Homo sapiens_hsa003100.73272258
103Allograft rejection_Homo sapiens_hsa053300.72703931
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72652184
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72578579
106Influenza A_Homo sapiens_hsa051640.72005138
107Renin-angiotensin system_Homo sapiens_hsa046140.70739050
108Herpes simplex infection_Homo sapiens_hsa051680.70257444
109Malaria_Homo sapiens_hsa051440.68856384
110Bladder cancer_Homo sapiens_hsa052190.68208109
111Choline metabolism in cancer_Homo sapiens_hsa052310.66829323
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66682884
113Inositol phosphate metabolism_Homo sapiens_hsa005620.66578300
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66107908
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65501816
116Amoebiasis_Homo sapiens_hsa051460.65459803
117Salmonella infection_Homo sapiens_hsa051320.64873565
118Autoimmune thyroid disease_Homo sapiens_hsa053200.64078778
119Pathways in cancer_Homo sapiens_hsa052000.62813128
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62534946
121GnRH signaling pathway_Homo sapiens_hsa049120.62219355
122Prostate cancer_Homo sapiens_hsa052150.61943609
123Long-term potentiation_Homo sapiens_hsa047200.61525413
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.60885064
125Pentose phosphate pathway_Homo sapiens_hsa000300.60879261
126AMPK signaling pathway_Homo sapiens_hsa041520.60610675
127Phenylalanine metabolism_Homo sapiens_hsa003600.60357405
128Olfactory transduction_Homo sapiens_hsa047400.59960984
129Sphingolipid metabolism_Homo sapiens_hsa006000.55987601
130Starch and sucrose metabolism_Homo sapiens_hsa005000.52928590
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52396310
132Rheumatoid arthritis_Homo sapiens_hsa053230.46305715
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.45156283
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.44912724
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44148884

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