ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female receptivity (GO:0045924)	6.03916261
2	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	5.73462880
3	adaptation of signaling pathway (GO:0023058)	5.65030962
4	piRNA metabolic process (GO:0034587)	5.49164354
5	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	5.17813333
6	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	5.17813333
7	serotonin metabolic process (GO:0042428)	5.14141172
8	female mating behavior (GO:0060180)	5.03722994
9	DNA methylation involved in gamete generation (GO:0043046)	4.99672254
10	neuronal action potential (GO:0019228)	4.93744887
11	regulation of acrosome reaction (GO:0060046)	4.86660661
12	primary amino compound metabolic process (GO:1901160)	4.74244370
13	regulation of interleukin-12 biosynthetic process (GO:0045075)	4.69416694
14	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.67298978
15	regulation of MHC class II biosynthetic process (GO:0045346)	4.64189673
16	meiotic chromosome segregation (GO:0045132)	4.60191361
17	male meiosis (GO:0007140)	4.34321234
18	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	4.16205151
19	male meiosis I (GO:0007141)	4.15175572
20	fusion of sperm to egg plasma membrane (GO:0007342)	4.10648566
21	indolalkylamine metabolic process (GO:0006586)	4.06806451
22	positive regulation of action potential (GO:0045760)	4.00394174
23	regulation of podosome assembly (GO:0071801)	3.88872459
24	neuron maturation (GO:0042551)	3.85783020
25	macroautophagy (GO:0016236)	3.85724938
26	tryptophan catabolic process (GO:0006569)	3.82158551
27	indole-containing compound catabolic process (GO:0042436)	3.82158551
28	indolalkylamine catabolic process (GO:0046218)	3.82158551
29	indole-containing compound metabolic process (GO:0042430)	3.82132507
30	negative regulation of metanephros development (GO:0072217)	3.80871081
31	signal peptide processing (GO:0006465)	3.72246116
32	toxin metabolic process (GO:0009404)	3.70589035
33	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	3.68649848
34	sex differentiation (GO:0007548)	3.64053239
35	membrane depolarization during action potential (GO:0086010)	3.60641395
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.60357234
37	regulation of vitamin D biosynthetic process (GO:0060556)	3.53066505
38	synapsis (GO:0007129)	3.46619101
39	chromosome organization involved in meiosis (GO:0070192)	3.43478492
40	dopamine biosynthetic process (GO:0042416)	3.42771851
41	synaptonemal complex assembly (GO:0007130)	3.38279744
42	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.37433767
43	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	3.36141447
44	negative regulation of kidney development (GO:0090185)	3.25482056
45	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.23488334
46	positive regulation of muscle cell apoptotic process (GO:0010661)	3.19853012
47	meiotic nuclear division (GO:0007126)	3.16989029
48	transmission of nerve impulse (GO:0019226)	3.12019175
49	histone H4-K12 acetylation (GO:0043983)	3.12002064
50	kynurenine metabolic process (GO:0070189)	3.10657297
51	plasma membrane fusion (GO:0045026)	3.09081905
52	synaptonemal complex organization (GO:0070193)	3.08964084
53	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.06812475
54	protein localization to synapse (GO:0035418)	3.05389926
55	tryptophan metabolic process (GO:0006568)	3.05033245
56	female gamete generation (GO:0007292)	3.04981351
57	regulation of smooth muscle cell apoptotic process (GO:0034391)	3.04436004
58	histone H3-K36 demethylation (GO:0070544)	3.03827230
59	meiosis I (GO:0007127)	3.03322725
60	histone H3-K9 demethylation (GO:0033169)	3.02655042
61	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.02114418
62	retina layer formation (GO:0010842)	3.01381463
63	growth hormone receptor signaling pathway (GO:0060396)	3.00498809
64	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.98197212
65	mesenchymal-epithelial cell signaling (GO:0060638)	2.96574052
66	retinal metabolic process (GO:0042574)	2.96283666
67	regulation of meiosis I (GO:0060631)	2.94551475
68	negative regulation of neurological system process (GO:0031645)	2.93171656
69	regulation of action potential (GO:0098900)	2.92784851
70	interkinetic nuclear migration (GO:0022027)	2.91116044
71	regulation of isotype switching to IgG isotypes (GO:0048302)	2.88260378
72	positive regulation of response to oxidative stress (GO:1902884)	2.88154500
73	positive regulation of cellular response to oxidative stress (GO:1900409)	2.88154500
74	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.86230149
75	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.85787094
76	positive regulation of chemokine biosynthetic process (GO:0045080)	2.85727884
77	righting reflex (GO:0060013)	2.82726639
78	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	2.81494431
79	regulation of metanephros development (GO:0072215)	2.79357667
80	diterpenoid biosynthetic process (GO:0016102)	2.75264282
81	intestinal epithelial cell development (GO:0060576)	2.74027066
82	benzene-containing compound metabolic process (GO:0042537)	2.73237608
83	alkaloid metabolic process (GO:0009820)	2.72190835
84	carnitine transport (GO:0015879)	2.71726351
85	amino-acid betaine transport (GO:0015838)	2.71726351
86	behavioral response to nicotine (GO:0035095)	2.71107562
87	regulation of memory T cell differentiation (GO:0043380)	2.70298798
88	cellular response to growth hormone stimulus (GO:0071378)	2.67731827
89	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.67462415
90	regulation of NFAT protein import into nucleus (GO:0051532)	2.67032969
91	reproductive behavior (GO:0019098)	2.65378315
92	cellular ketone body metabolic process (GO:0046950)	2.64414018
93	T cell differentiation involved in immune response (GO:0002292)	2.64340027
94	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.64340027
95	alpha-beta T cell activation involved in immune response (GO:0002287)	2.64340027
96	regulation of hippo signaling (GO:0035330)	2.64162290
97	establishment of nucleus localization (GO:0040023)	2.63596922
98	synaptic transmission, dopaminergic (GO:0001963)	2.63543979
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.62618069
100	mating behavior (GO:0007617)	2.61903400

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.60139468
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.09122204
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.36155190
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.69401498
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35724836
6	AR_21572438_ChIP-Seq_LNCaP_Human	2.33702950
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17753915
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10887490
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06429606
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04794859
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.95775139
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94705064
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92956238
14	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90588842
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.90588842
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87491858
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.87026276
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84008452
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82225334
20	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.80852424
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.79546896
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.76809323
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.76073144
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73380769
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71069061
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70868941
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68593792
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63860313
29	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.62482705
30	P300_19829295_ChIP-Seq_ESCs_Human	1.59263753
31	STAT3_23295773_ChIP-Seq_U87_Human	1.57843100
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.56975854
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.56665185
34	TCF4_23295773_ChIP-Seq_U87_Human	1.55837194
35	AHR_22903824_ChIP-Seq_MCF-7_Human	1.53760151
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51831446
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.48115187
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47813684
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47717164
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43195189
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38959067
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35613261
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35509896
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35187781
45	EWS_26573619_Chip-Seq_HEK293_Human	1.34457855
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33239992
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31800253
48	FUS_26573619_Chip-Seq_HEK293_Human	1.31218524
49	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.29480801
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.29156412
51	AR_25329375_ChIP-Seq_VCAP_Human	1.29024406
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28181512
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25273981
54	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24780495
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23018919
56	TBL1_22424771_ChIP-Seq_293T_Human	1.20438106
57	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20384470
58	RXR_22108803_ChIP-Seq_LS180_Human	1.19097779
59	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.18682633
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.18592950
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16742498
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13394193
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10993822
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10756240
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10428892
66	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08683519
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07903441
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07820414
69	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07798540
70	NFYA_21822215_ChIP-Seq_K562_Human	1.06077758
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05761436
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.05429496
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04379695
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04334489
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03797740
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03388361
77	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02822161
78	AR_19668381_ChIP-Seq_PC3_Human	1.02607111
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02328763
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.02328763
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01317829
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01214579
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00561887
84	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00458827
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00405126
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00405126
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00404192
88	NFYB_21822215_ChIP-Seq_K562_Human	0.99995729
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99691178
90	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.98683328
91	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.98450832
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98393582
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97987387
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97893039
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.97860237
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97310897
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97083367
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.95805677
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.94984945
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93955447

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.73552979
2	MP0008877_abnormal_DNA_methylation	4.17648638
3	MP0009780_abnormal_chondrocyte_physiolo	3.33097993
4	MP0002736_abnormal_nociception_after	3.22383551
5	MP0001873_stomach_inflammation	3.20959289
6	MP0001501_abnormal_sleep_pattern	3.15540407
7	MP0001968_abnormal_touch/_nociception	2.97048705
8	MP0001986_abnormal_taste_sensitivity	2.87681077
9	MP0003136_yellow_coat_color	2.86344031
10	MP0001958_emphysema	2.48339474
11	MP0005174_abnormal_tail_pigmentation	2.38259532
12	MP0006276_abnormal_autonomic_nervous	2.26110652
13	MP0002909_abnormal_adrenal_gland	2.25802659
14	MP0000383_abnormal_hair_follicle	2.25316574
15	MP0005167_abnormal_blood-brain_barrier	2.20493039
16	MP0002735_abnormal_chemical_nociception	2.16475201
17	MP0005503_abnormal_tendon_morphology	2.07077398
18	MP0002733_abnormal_thermal_nociception	1.92031272
19	MP0003646_muscle_fatigue	1.89181906
20	MP0003880_abnormal_central_pattern	1.86237230
21	MP0003119_abnormal_digestive_system	1.83117931
22	MP0002210_abnormal_sex_determination	1.80117725
23	MP0000427_abnormal_hair_cycle	1.73563964
24	MP0004742_abnormal_vestibular_system	1.70726219
25	MP0005551_abnormal_eye_electrophysiolog	1.64777059
26	MP0005423_abnormal_somatic_nervous	1.60543954
27	MP0004019_abnormal_vitamin_homeostasis	1.59943523
28	MP0004133_heterotaxia	1.59633259
29	MP0009745_abnormal_behavioral_response	1.47777438
30	MP0000015_abnormal_ear_pigmentation	1.47726313
31	MP0004043_abnormal_pH_regulation	1.45616847
32	MP0006072_abnormal_retinal_apoptosis	1.43539454
33	MP0002234_abnormal_pharynx_morphology	1.38682284
34	MP0001970_abnormal_pain_threshold	1.38461121
35	MP0005408_hypopigmentation	1.35935302
36	MP0001905_abnormal_dopamine_level	1.31839375
37	MP0002572_abnormal_emotion/affect_behav	1.30349727
38	MP0003698_abnormal_male_reproductive	1.29090170
39	MP0002653_abnormal_ependyma_morphology	1.29013340
40	MP0010678_abnormal_skin_adnexa	1.24646600
41	MP0002272_abnormal_nervous_system	1.23531797
42	MP0004782_abnormal_surfactant_physiolog	1.21490958
43	MP0002102_abnormal_ear_morphology	1.18033822
44	MP0002063_abnormal_learning/memory/cond	1.15913790
45	MP0008995_early_reproductive_senescence	1.15723191
46	MP0000653_abnormal_sex_gland	1.13061261
47	MP0001756_abnormal_urination	1.11371206
48	MP0001929_abnormal_gametogenesis	1.11029800
49	MP0009046_muscle_twitch	1.08238636
50	MP0005253_abnormal_eye_physiology	1.07071608
51	MP0000013_abnormal_adipose_tissue	1.06707449
52	MP0000538_abnormal_urinary_bladder	1.05265054
53	MP0004885_abnormal_endolymph	1.04845445
54	MP0002064_seizures	1.04015653
55	MP0005310_abnormal_salivary_gland	1.01616927
56	MP0003936_abnormal_reproductive_system	1.01031884
57	MP0003937_abnormal_limbs/digits/tail_de	0.99470003
58	MP0002734_abnormal_mechanical_nocicepti	0.97434475
59	MP0001502_abnormal_circadian_rhythm	0.97324216
60	MP0002184_abnormal_innervation	0.97316611
61	MP0001145_abnormal_male_reproductive	0.97127994
62	MP0008057_abnormal_DNA_replication	0.95944864
63	MP0001542_abnormal_bone_strength	0.95669118
64	MP0001486_abnormal_startle_reflex	0.93936268
65	MP0003635_abnormal_synaptic_transmissio	0.93630568
66	MP0003879_abnormal_hair_cell	0.92875571
67	MP0001188_hyperpigmentation	0.91656142
68	MP0002067_abnormal_sensory_capabilities	0.90228613
69	MP0002876_abnormal_thyroid_physiology	0.89289147
70	MP0003787_abnormal_imprinting	0.89229659
71	MP0004130_abnormal_muscle_cell	0.89225426
72	MP0005646_abnormal_pituitary_gland	0.86651745
73	MP0001765_abnormal_ion_homeostasis	0.86324957
74	MP0005275_abnormal_skin_tensile	0.86113009
75	MP0002693_abnormal_pancreas_physiology	0.85524695
76	MP0002136_abnormal_kidney_physiology	0.84991540
77	MP0000230_abnormal_systemic_arterial	0.82864457
78	MP0000371_diluted_coat_color	0.81879851
79	MP0002132_abnormal_respiratory_system	0.81312532
80	MP0003045_fibrosis	0.81029735
81	MP0002557_abnormal_social/conspecific_i	0.81020224
82	MP0001664_abnormal_digestion	0.79001065
83	MP0003122_maternal_imprinting	0.77899476
84	MP0003195_calcinosis	0.75925005
85	MP0002928_abnormal_bile_duct	0.74863327
86	MP0004270_analgesia	0.72076228
87	MP0002160_abnormal_reproductive_system	0.71292957
88	MP0001835_abnormal_antigen_presentation	0.70447874
89	MP0003890_abnormal_embryonic-extraembry	0.69999190
90	MP0002168_other_aberrant_phenotype	0.68837747
91	MP0003943_abnormal_hepatobiliary_system	0.68288614
92	MP0003953_abnormal_hormone_level	0.67488209
93	MP0002075_abnormal_coat/hair_pigmentati	0.64908828
94	MP0003633_abnormal_nervous_system	0.64729241
95	MP0005409_darkened_coat_color	0.63931835
96	MP0002078_abnormal_glucose_homeostasis	0.62831733
97	MP0002933_joint_inflammation	0.61810859
98	MP0002161_abnormal_fertility/fecundity	0.61630707
99	MP0009250_abnormal_appendicular_skeleto	0.61105018
100	MP0003638_abnormal_response/metabolism_	0.59845836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.92428984
2	Hyperventilation (HP:0002883)	4.48570455
3	11 pairs of ribs (HP:0000878)	3.60243476
4	Horizontal nystagmus (HP:0000666)	3.50090630
5	Thyroid-stimulating hormone excess (HP:0002925)	3.35092842
6	Hypothermia (HP:0002045)	3.32601631
7	Concave nail (HP:0001598)	3.29933556
8	Abnormality of the vertebral endplates (HP:0005106)	3.25868328
9	Fibular hypoplasia (HP:0003038)	3.18503902
10	Drooling (HP:0002307)	3.11987987
11	Inability to walk (HP:0002540)	3.07980454
12	True hermaphroditism (HP:0010459)	3.02672346
13	Irregular vertebral endplates (HP:0003301)	2.99314488
14	Azoospermia (HP:0000027)	2.94220733
15	Enlarged epiphyses (HP:0010580)	2.86308558
16	Excessive salivation (HP:0003781)	2.85422556
17	Type I transferrin isoform profile (HP:0003642)	2.85170469
18	Action tremor (HP:0002345)	2.76227680
19	Abnormality of midbrain morphology (HP:0002418)	2.74026850
20	Molar tooth sign on MRI (HP:0002419)	2.74026850
21	Mild short stature (HP:0003502)	2.73671607
22	Increased corneal curvature (HP:0100692)	2.73360681
23	Keratoconus (HP:0000563)	2.73360681
24	Generalized hypopigmentation of hair (HP:0011358)	2.73182525
25	Hypoplasia of the pons (HP:0012110)	2.72303187
26	Absent frontal sinuses (HP:0002688)	2.70210357
27	Pancreatic cysts (HP:0001737)	2.61994041
28	Gaze-evoked nystagmus (HP:0000640)	2.60480994
29	Progressive cerebellar ataxia (HP:0002073)	2.60413944
30	Choroideremia (HP:0001139)	2.59071251
31	Protruding tongue (HP:0010808)	2.56907844
32	Hypoplastic iliac wings (HP:0002866)	2.56280212
33	Febrile seizures (HP:0002373)	2.56052446
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.55690812
35	Metaphyseal cupping (HP:0003021)	2.54736256
36	Abnormality of homocysteine metabolism (HP:0010919)	2.51041461
37	Homocystinuria (HP:0002156)	2.51041461
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.50935646
39	Abnormal protein N-linked glycosylation (HP:0012347)	2.50935646
40	Abnormal protein glycosylation (HP:0012346)	2.50935646
41	Abnormal glycosylation (HP:0012345)	2.50935646
42	Limb dystonia (HP:0002451)	2.50057232
43	Abnormality of the pons (HP:0007361)	2.49430972
44	Fair hair (HP:0002286)	2.48425562
45	Attenuation of retinal blood vessels (HP:0007843)	2.46609280
46	Flattened epiphyses (HP:0003071)	2.45335494
47	Epileptic encephalopathy (HP:0200134)	2.41007335
48	Stomach cancer (HP:0012126)	2.33068062
49	Hypoplastic nipples (HP:0002557)	2.32720878
50	Cystic liver disease (HP:0006706)	2.32476484
51	Abnormality of the lower motor neuron (HP:0002366)	2.32040405
52	Central scotoma (HP:0000603)	2.31310994
53	Broad-based gait (HP:0002136)	2.26088762
54	Tubular atrophy (HP:0000092)	2.23001282
55	Widely spaced teeth (HP:0000687)	2.19396162
56	Severe Myopia (HP:0011003)	2.18165815
57	Nephronophthisis (HP:0000090)	2.17303695
58	Acute lymphatic leukemia (HP:0006721)	2.13995730
59	Hypoplastic ischia (HP:0003175)	2.11210271
60	Severe visual impairment (HP:0001141)	2.11012229
61	Pigmentary retinal degeneration (HP:0001146)	2.10168264
62	Abnormal rod and cone electroretinograms (HP:0008323)	2.08726877
63	Absent/shortened dynein arms (HP:0200106)	2.08603559
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08603559
65	Prominent supraorbital ridges (HP:0000336)	2.08569129
66	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.08238399
67	Abnormality of femoral epiphyses (HP:0006499)	2.08238399
68	Tubulointerstitial nephritis (HP:0001970)	2.08180706
69	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.07291646
70	Hypoproteinemia (HP:0003075)	2.05899344
71	Abnormality of the femoral head (HP:0003368)	2.05609064
72	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.04458505
73	Conical tooth (HP:0000698)	2.02483239
74	Abnormality of chloride homeostasis (HP:0011422)	2.01198244
75	Rimmed vacuoles (HP:0003805)	1.99913833
76	Mesangial abnormality (HP:0001966)	1.98784693
77	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.98037995
78	Pancreatic fibrosis (HP:0100732)	1.95418077
79	Abnormality of macular pigmentation (HP:0008002)	1.95396614
80	Abnormality of the renal medulla (HP:0100957)	1.91818202
81	Large for gestational age (HP:0001520)	1.90917551
82	Biconcave vertebral bodies (HP:0004586)	1.90192279
83	Spondylolisthesis (HP:0003302)	1.89481092
84	Myokymia (HP:0002411)	1.89428639
85	Delayed CNS myelination (HP:0002188)	1.89252365
86	Absence seizures (HP:0002121)	1.86987907
87	Neonatal respiratory distress (HP:0002643)	1.86101701
88	Lip pit (HP:0100267)	1.84768146
89	Abnormal albumin level (HP:0012116)	1.84041714
90	Hypoalbuminemia (HP:0003073)	1.84041714
91	Gastroesophageal reflux (HP:0002020)	1.82151562
92	Persistence of primary teeth (HP:0006335)	1.81169850
93	Pheochromocytoma (HP:0002666)	1.80572741
94	Hyperkalemia (HP:0002153)	1.79957193
95	Dialeptic seizures (HP:0011146)	1.79800845
96	Intellectual disability, progressive (HP:0006887)	1.78811263
97	Abnormality of the frontal sinuses (HP:0002687)	1.76799336
98	Scotoma (HP:0000575)	1.76303428
99	Abnormality of salivation (HP:0100755)	1.76195865
100	Atonic seizures (HP:0010819)	1.73914003

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.58737960
2	FRK	5.11059480
3	CASK	3.70196591
4	WNK4	3.48110559
5	MAP3K9	3.46944056
6	BMPR1B	3.26181470
7	MET	2.75205376
8	CAMK1G	2.39474301
9	PTK2B	2.16310214
10	MAP3K10	1.98966277
11	ZAK	1.98505823
12	MKNK2	1.94240776
13	ADRBK2	1.81588641
14	WNK1	1.80855284
15	MAPK13	1.73970023
16	TSSK6	1.68745702
17	PDGFRB	1.48814040
18	TLK1	1.46158939
19	AKT3	1.35061056
20	BMX	1.34866882
21	EEF2K	1.32947796
22	CSF1R	1.32839329
23	FGR	1.32072239
24	PTK2	1.32053340
25	MAPKAPK5	1.29547774
26	PDK2	1.29240427
27	RET	1.24038443
28	PINK1	1.23721122
29	DAPK2	1.23023367
30	TXK	1.19863684
31	EPHA4	1.17805126
32	MYLK	1.17753043
33	NME1	1.14827025
34	OXSR1	1.14805329
35	PLK2	1.13924542
36	TRIB3	1.04117052
37	MARK1	1.00829101
38	NLK	0.96681868
39	TNK2	0.94530210
40	SIK2	0.93254879
41	STK38L	0.89263665
42	TNIK	0.83810670
43	STK38	0.80104865
44	SGK2	0.79128400
45	MKNK1	0.79008956
46	NTRK3	0.78137083
47	ROCK1	0.77374510
48	TGFBR1	0.74057301
49	PRKD3	0.73576191
50	GRK1	0.72797158
51	TAOK3	0.68692575
52	MAP2K6	0.68377539
53	SGK1	0.62709165
54	MINK1	0.61717690
55	SGK494	0.61217889
56	SGK223	0.61217889
57	INSRR	0.61004564
58	TYRO3	0.58241750
59	CAMK1	0.58072805
60	ADRBK1	0.57602934
61	MAPKAPK3	0.56632409
62	PAK6	0.55678763
63	PLK4	0.53691746
64	PRKCE	0.50017097
65	WNK3	0.49860275
66	NEK6	0.48535501
67	MAPK7	0.47430188
68	MTOR	0.46501996
69	MAPK12	0.46030625
70	CHUK	0.44266567
71	CAMK2A	0.40967774
72	NTRK2	0.38618603
73	RPS6KA5	0.38388354
74	MAP3K4	0.37801266
75	TRPM7	0.37693911
76	ERBB2	0.37419914
77	CDK5	0.36452304
78	DYRK2	0.35265930
79	TAOK1	0.34834199
80	PRKAA2	0.34814377
81	PAK3	0.33433631
82	ACVR1B	0.30886390
83	PIK3CA	0.30871524
84	CAMK4	0.30073644
85	EPHA3	0.30062809
86	CDC42BPA	0.29698585
87	MAP3K7	0.29263631
88	PRKCZ	0.28452276
89	PIK3CG	0.27940535
90	PRKAA1	0.27842641
91	MAP4K2	0.27791726
92	DMPK	0.26678435
93	CSNK1E	0.26002951
94	KIT	0.25691323
95	STK39	0.25298640
96	MAPK1	0.23087696
97	CDK8	0.22578617
98	ATM	0.21547846
99	PASK	0.21366758
100	PKN2	0.20935429

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.55040580
2	Tryptophan metabolism_Homo sapiens_hsa00380	3.40971160
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.40323178
4	Butanoate metabolism_Homo sapiens_hsa00650	3.05321507
5	Nicotine addiction_Homo sapiens_hsa05033	2.67967670
6	Regulation of autophagy_Homo sapiens_hsa04140	2.45748797
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38258062
8	Taste transduction_Homo sapiens_hsa04742	2.37328633
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33810103
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07246569
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.04464441
12	ABC transporters_Homo sapiens_hsa02010	1.96776685
13	Olfactory transduction_Homo sapiens_hsa04740	1.96449606
14	African trypanosomiasis_Homo sapiens_hsa05143	1.56538195
15	Histidine metabolism_Homo sapiens_hsa00340	1.45830486
16	Phototransduction_Homo sapiens_hsa04744	1.44822015
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.43066691
18	Serotonergic synapse_Homo sapiens_hsa04726	1.38220845
19	Cocaine addiction_Homo sapiens_hsa05030	1.36460524
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.35617792
21	Malaria_Homo sapiens_hsa05144	1.34828511
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.34204624
23	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.32416451
24	Lysine degradation_Homo sapiens_hsa00310	1.26105113
25	Salivary secretion_Homo sapiens_hsa04970	1.25662635
26	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.19486710
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.17376641
28	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.16419016
29	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.13788544
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.11771201
31	Circadian entrainment_Homo sapiens_hsa04713	1.11173359
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.10881877
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09961765
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08989587
35	Amphetamine addiction_Homo sapiens_hsa05031	1.08347940
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06517005
37	GABAergic synapse_Homo sapiens_hsa04727	1.02550074
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.02061697
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.99628597
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99352755
41	Dopaminergic synapse_Homo sapiens_hsa04728	0.98522721
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97158948
43	Mineral absorption_Homo sapiens_hsa04978	0.93605091
44	Protein export_Homo sapiens_hsa03060	0.91407689
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90624538
46	Morphine addiction_Homo sapiens_hsa05032	0.89952500
47	Long-term depression_Homo sapiens_hsa04730	0.88969821
48	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.88917743
49	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88481662
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.87180720
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86594299
52	Folate biosynthesis_Homo sapiens_hsa00790	0.85294560
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84139068
54	Retinol metabolism_Homo sapiens_hsa00830	0.82659938
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79897837
56	Bile secretion_Homo sapiens_hsa04976	0.78385435
57	Salmonella infection_Homo sapiens_hsa05132	0.76112638
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.75987881
59	Homologous recombination_Homo sapiens_hsa03440	0.74319743
60	Fatty acid degradation_Homo sapiens_hsa00071	0.74128837
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74057990
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72971299
63	Amoebiasis_Homo sapiens_hsa05146	0.72962399
64	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.71815256
65	Basal transcription factors_Homo sapiens_hsa03022	0.68902267
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.66544747
67	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66009302
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65961839
69	Tight junction_Homo sapiens_hsa04530	0.63037801
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61070075
71	Caffeine metabolism_Homo sapiens_hsa00232	0.56760531
72	Sulfur relay system_Homo sapiens_hsa04122	0.55176742
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54636605
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.52897347
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.51561051
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50458776
77	Allograft rejection_Homo sapiens_hsa05330	0.48665127
78	Peroxisome_Homo sapiens_hsa04146	0.48035515
79	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47891967
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47710892
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45301540
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44832787
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.44180070
84	One carbon pool by folate_Homo sapiens_hsa00670	0.43604904
85	Propanoate metabolism_Homo sapiens_hsa00640	0.42568956
86	Insulin resistance_Homo sapiens_hsa04931	0.40267091
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39038183
88	Insulin secretion_Homo sapiens_hsa04911	0.37818511
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36528369
90	Cholinergic synapse_Homo sapiens_hsa04725	0.34711174
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34010685
92	Estrogen signaling pathway_Homo sapiens_hsa04915	0.33724672
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32220787
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.31885889
95	Choline metabolism in cancer_Homo sapiens_hsa05231	0.31740534
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.31299884
97	Oocyte meiosis_Homo sapiens_hsa04114	0.31167167
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.31160264
99	Prostate cancer_Homo sapiens_hsa05215	0.30825219
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29860980

GRAMD4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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