ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.17350931
2	kynurenine metabolic process (GO:0070189)	4.34547629
3	indole-containing compound catabolic process (GO:0042436)	4.29739585
4	indolalkylamine catabolic process (GO:0046218)	4.29739585
5	tryptophan catabolic process (GO:0006569)	4.29739585
6	indolalkylamine metabolic process (GO:0006586)	4.13631507
7	fucose catabolic process (GO:0019317)	4.09367002
8	L-fucose metabolic process (GO:0042354)	4.09367002
9	L-fucose catabolic process (GO:0042355)	4.09367002
10	response to pheromone (GO:0019236)	4.01077823
11	neural tube formation (GO:0001841)	3.84206175
12	tryptophan metabolic process (GO:0006568)	3.81105003
13	detection of light stimulus involved in visual perception (GO:0050908)	3.61209071
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.61209071
15	gamma-aminobutyric acid transport (GO:0015812)	3.55375050
16	sulfation (GO:0051923)	3.52362019
17	establishment of protein localization to Golgi (GO:0072600)	3.49547722
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47631347
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.42546099
20	cornea development in camera-type eye (GO:0061303)	3.34301192
21	indole-containing compound metabolic process (GO:0042430)	3.32363014
22	serotonin metabolic process (GO:0042428)	3.16407924
23	neuronal action potential (GO:0019228)	3.07283555
24	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.01981381
25	primary amino compound metabolic process (GO:1901160)	3.01896671
26	epithelial cilium movement (GO:0003351)	3.01598432
27	oxidative demethylation (GO:0070989)	2.99966016
28	regulation of hippo signaling (GO:0035330)	2.98957157
29	cAMP catabolic process (GO:0006198)	2.97392900
30	adaptation of signaling pathway (GO:0023058)	2.97227673
31	reflex (GO:0060004)	2.94996230
32	signal peptide processing (GO:0006465)	2.94197961
33	amine catabolic process (GO:0009310)	2.88637783
34	cellular biogenic amine catabolic process (GO:0042402)	2.88637783
35	protein localization to cilium (GO:0061512)	2.86891653
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.85809671
37	negative regulation of telomere maintenance (GO:0032205)	2.83771600
38	cellular ketone body metabolic process (GO:0046950)	2.82401700
39	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.81787919
40	cilium morphogenesis (GO:0060271)	2.79682185
41	snRNA transcription (GO:0009301)	2.77857840
42	cilium organization (GO:0044782)	2.76507601
43	negative regulation of mast cell activation (GO:0033004)	2.75261004
44	negative regulation of systemic arterial blood pressure (GO:0003085)	2.74056613
45	cyclic nucleotide catabolic process (GO:0009214)	2.73238432
46	regulation of action potential (GO:0098900)	2.73188528
47	protein K11-linked deubiquitination (GO:0035871)	2.73061751
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.72681664
49	membrane depolarization during action potential (GO:0086010)	2.72499540
50	cilium assembly (GO:0042384)	2.68397804
51	cell proliferation in forebrain (GO:0021846)	2.67227860
52	benzene-containing compound metabolic process (GO:0042537)	2.65008709
53	positive regulation of developmental pigmentation (GO:0048087)	2.64826923
54	photoreceptor cell development (GO:0042461)	2.64329245
55	regulation of gene silencing by RNA (GO:0060966)	2.62946043
56	regulation of posttranscriptional gene silencing (GO:0060147)	2.62946043
57	regulation of gene silencing by miRNA (GO:0060964)	2.62946043
58	regulation of cilium movement (GO:0003352)	2.62423152
59	regulation of mesoderm development (GO:2000380)	2.61844090
60	behavioral response to ethanol (GO:0048149)	2.60570499
61	protein targeting to Golgi (GO:0000042)	2.60035087
62	synaptic transmission, cholinergic (GO:0007271)	2.59987879
63	negative regulation of sodium ion transport (GO:0010766)	2.58836315
64	photoreceptor cell maintenance (GO:0045494)	2.58368625
65	DNA deamination (GO:0045006)	2.58159671
66	regulation of pigment cell differentiation (GO:0050932)	2.55686810
67	cilium movement (GO:0003341)	2.55368336
68	rRNA catabolic process (GO:0016075)	2.53671412
69	nonmotile primary cilium assembly (GO:0035058)	2.53036585
70	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52267339
71	thyroid hormone metabolic process (GO:0042403)	2.50820839
72	ketone body metabolic process (GO:1902224)	2.50594642
73	transmission of nerve impulse (GO:0019226)	2.50386943
74	neuronal action potential propagation (GO:0019227)	2.50383224
75	embryonic epithelial tube formation (GO:0001838)	2.49318588
76	protein polyglutamylation (GO:0018095)	2.48898233
77	protein localization to Golgi apparatus (GO:0034067)	2.47961611
78	spinal cord motor neuron differentiation (GO:0021522)	2.47565935
79	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.47424888
80	multicellular organism reproduction (GO:0032504)	2.47131336
81	axoneme assembly (GO:0035082)	2.47086834
82	rhodopsin mediated signaling pathway (GO:0016056)	2.45692844
83	retinal cone cell development (GO:0046549)	2.45383795
84	limb development (GO:0060173)	2.43441944
85	appendage development (GO:0048736)	2.43441944
86	regulation of establishment of cell polarity (GO:2000114)	2.43214360
87	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.42089785
88	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.40360916
89	regulation of translation, ncRNA-mediated (GO:0045974)	2.40360916
90	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.40360916
91	protein prenylation (GO:0018342)	2.39992192
92	prenylation (GO:0097354)	2.39992192
93	pyrimidine nucleobase catabolic process (GO:0006208)	2.39674407
94	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.38557450
95	somite development (GO:0061053)	2.38485566
96	cellular response to ATP (GO:0071318)	2.38209535
97	nephron tubule morphogenesis (GO:0072078)	2.37898622
98	nephron epithelium morphogenesis (GO:0072088)	2.37898622
99	NAD biosynthetic process (GO:0009435)	2.37383344
100	eye photoreceptor cell development (GO:0042462)	2.36878427

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.33164580
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.31958498
3	VDR_22108803_ChIP-Seq_LS180_Human	3.17556976
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13307751
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.69559053
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69082314
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61695225
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.48158450
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47948110
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.39372288
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24997752
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22711680
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.15236967
14	P300_19829295_ChIP-Seq_ESCs_Human	2.11300452
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09361713
16	EWS_26573619_Chip-Seq_HEK293_Human	2.08776017
17	FUS_26573619_Chip-Seq_HEK293_Human	2.07054450
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90641491
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.87881264
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.84448965
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78463431
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78043233
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.77239873
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76647474
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76384303
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70644305
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65697201
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64983542
29	STAT3_23295773_ChIP-Seq_U87_Human	1.64647490
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62863594
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.62863594
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.60436613
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59101822
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.56000732
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54459932
36	TCF4_23295773_ChIP-Seq_U87_Human	1.53135946
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51262716
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51262716
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51052757
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50708966
41	AR_25329375_ChIP-Seq_VCAP_Human	1.50279269
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49894433
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49522831
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48997977
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44843566
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44003950
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43981745
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43703905
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.40265335
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38143316
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38065554
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34736631
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33963846
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33455535
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31534813
56	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31504390
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30182218
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30087793
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.29828841
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29072781
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27941392
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.27509368
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26834231
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24929451
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23303896
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23303896
67	TP53_16413492_ChIP-PET_HCT116_Human	1.22335031
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21898669
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21816789
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21718407
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.20335502
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19960411
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19017879
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17881715
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17224508
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15965091
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15523580
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14299234
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12600411
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11924466
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11660066
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10749882
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10749882
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10317225
85	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.09533871
86	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.08481436
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07940309
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05734311
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05603741
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05309168
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03734935
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03707717
93	CDX2_22108803_ChIP-Seq_LS180_Human	1.02120288
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01903689
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01611796
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01564258
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01266932
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01174938
99	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00402557
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99386129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.24847575
2	MP0006292_abnormal_olfactory_placode	2.88938208
3	MP0008877_abnormal_DNA_methylation	2.83734370
4	MP0003195_calcinosis	2.72442288
5	MP0003787_abnormal_imprinting	2.59179648
6	MP0005551_abnormal_eye_electrophysiolog	2.55474253
7	MP0001968_abnormal_touch/_nociception	2.33706236
8	MP0002102_abnormal_ear_morphology	2.32850021
9	MP0009046_muscle_twitch	2.23794641
10	MP0002837_dystrophic_cardiac_calcinosis	2.08868246
11	MP0002736_abnormal_nociception_after	2.07302118
12	MP0004043_abnormal_pH_regulation	1.96184155
13	MP0009745_abnormal_behavioral_response	1.95049877
14	MP0003136_yellow_coat_color	1.94988205
15	MP0003646_muscle_fatigue	1.91537658
16	MP0002272_abnormal_nervous_system	1.89475793
17	MP0006072_abnormal_retinal_apoptosis	1.88249139
18	MP0002638_abnormal_pupillary_reflex	1.82477602
19	MP0001501_abnormal_sleep_pattern	1.81388448
20	MP0001485_abnormal_pinna_reflex	1.80806838
21	MP0004142_abnormal_muscle_tone	1.76963220
22	MP0002735_abnormal_chemical_nociception	1.75008059
23	MP0002163_abnormal_gland_morphology	1.72458736
24	MP0005646_abnormal_pituitary_gland	1.72311864
25	MP0005253_abnormal_eye_physiology	1.68842566
26	MP0008872_abnormal_physiological_respon	1.66053599
27	MP0006276_abnormal_autonomic_nervous	1.64408848
28	MP0004885_abnormal_endolymph	1.64386658
29	MP0003880_abnormal_central_pattern	1.64314458
30	MP0000427_abnormal_hair_cycle	1.58760164
31	MP0003011_delayed_dark_adaptation	1.49556794
32	MP0001986_abnormal_taste_sensitivity	1.48765975
33	MP0002938_white_spotting	1.47652665
34	MP0002733_abnormal_thermal_nociception	1.47358125
35	MP0000631_abnormal_neuroendocrine_gland	1.47283247
36	MP0002572_abnormal_emotion/affect_behav	1.47098642
37	MP0002653_abnormal_ependyma_morphology	1.46510339
38	MP0004145_abnormal_muscle_electrophysio	1.46370045
39	MP0005379_endocrine/exocrine_gland_phen	1.45224944
40	MP0002064_seizures	1.42316450
41	MP0004133_heterotaxia	1.41557393
42	MP0005174_abnormal_tail_pigmentation	1.41475437
43	MP0001486_abnormal_startle_reflex	1.40513684
44	MP0001970_abnormal_pain_threshold	1.38067716
45	MP0002876_abnormal_thyroid_physiology	1.36047889
46	MP0003635_abnormal_synaptic_transmissio	1.33085280
47	MP0005645_abnormal_hypothalamus_physiol	1.31413813
48	MP0010386_abnormal_urinary_bladder	1.28539335
49	MP0002557_abnormal_social/conspecific_i	1.28371818
50	MP0004742_abnormal_vestibular_system	1.27951297
51	MP0000383_abnormal_hair_follicle	1.26481857
52	MP0003890_abnormal_embryonic-extraembry	1.26042437
53	MP0005386_behavior/neurological_phenoty	1.24670171
54	MP0004924_abnormal_behavior	1.24670171
55	MP0002063_abnormal_learning/memory/cond	1.21289989
56	MP0002928_abnormal_bile_duct	1.19748660
57	MP0002067_abnormal_sensory_capabilities	1.19375313
58	MP0008875_abnormal_xenobiotic_pharmacok	1.18487085
59	MP0002160_abnormal_reproductive_system	1.18482693
60	MP0005389_reproductive_system_phenotype	1.17236326
61	MP0002234_abnormal_pharynx_morphology	1.16776352
62	MP0001984_abnormal_olfaction	1.16593110
63	MP0004147_increased_porphyrin_level	1.15808219
64	MP0000372_irregular_coat_pigmentation	1.15301438
65	MP0005195_abnormal_posterior_eye	1.12594552
66	MP0003121_genomic_imprinting	1.12319299
67	MP0005084_abnormal_gallbladder_morpholo	1.12152699
68	MP0008057_abnormal_DNA_replication	1.10534663
69	MP0000230_abnormal_systemic_arterial	1.09566735
70	MP0002138_abnormal_hepatobiliary_system	1.07822545
71	MP0000778_abnormal_nervous_system	1.06062743
72	MP0008961_abnormal_basal_metabolism	1.04776903
73	MP0008789_abnormal_olfactory_epithelium	1.03282213
74	MP0004215_abnormal_myocardial_fiber	1.02699567
75	MP0002095_abnormal_skin_pigmentation	0.98520398
76	MP0002184_abnormal_innervation	0.98373781
77	MP0002752_abnormal_somatic_nervous	0.98144803
78	MP0002734_abnormal_mechanical_nocicepti	0.93497322
79	MP0000026_abnormal_inner_ear	0.90387921
80	MP0001324_abnormal_eye_pigmentation	0.89801616
81	MP0001919_abnormal_reproductive_system	0.89531311
82	MP0001963_abnormal_hearing_physiology	0.88639998
83	MP0001440_abnormal_grooming_behavior	0.85651047
84	MP0002229_neurodegeneration	0.83716823
85	MP0005423_abnormal_somatic_nervous	0.82742585
86	MP0005377_hearing/vestibular/ear_phenot	0.80907925
87	MP0003878_abnormal_ear_physiology	0.80907925
88	MP0005410_abnormal_fertilization	0.80574093
89	MP0003119_abnormal_digestive_system	0.78757387
90	MP0005167_abnormal_blood-brain_barrier	0.78716464
91	MP0008775_abnormal_heart_ventricle	0.78125953
92	MP0002882_abnormal_neuron_morphology	0.77809369
93	MP0005448_abnormal_energy_balance	0.77416227
94	MP0005085_abnormal_gallbladder_physiolo	0.77283290
95	MP0000647_abnormal_sebaceous_gland	0.76571261
96	MP0001905_abnormal_dopamine_level	0.76361966
97	MP0000955_abnormal_spinal_cord	0.75325418
98	MP0008995_early_reproductive_senescence	0.74908319
99	MP0002751_abnormal_autonomic_nervous	0.73448383
100	MP0002277_abnormal_respiratory_mucosa	0.72700494

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.80589778
2	Pancreatic fibrosis (HP:0100732)	4.61584697
3	True hermaphroditism (HP:0010459)	4.44302188
4	Abnormality of midbrain morphology (HP:0002418)	4.07020618
5	Molar tooth sign on MRI (HP:0002419)	4.07020618
6	Congenital stationary night blindness (HP:0007642)	4.06385525
7	Hyperventilation (HP:0002883)	3.75173918
8	Nephronophthisis (HP:0000090)	3.72538098
9	Medial flaring of the eyebrow (HP:0010747)	3.27256868
10	Abolished electroretinogram (ERG) (HP:0000550)	3.23954028
11	Cystic liver disease (HP:0006706)	3.21874946
12	Abnormality of the renal medulla (HP:0100957)	3.19649209
13	Progressive cerebellar ataxia (HP:0002073)	3.14468497
14	Abnormality of the renal cortex (HP:0011035)	3.05123831
15	Attenuation of retinal blood vessels (HP:0007843)	2.99770425
16	Genetic anticipation (HP:0003743)	2.93887163
17	Chronic hepatic failure (HP:0100626)	2.90478026
18	Gait imbalance (HP:0002141)	2.79437799
19	Gaze-evoked nystagmus (HP:0000640)	2.75742888
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.73268565
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.71797179
22	Tubular atrophy (HP:0000092)	2.70926434
23	Protruding tongue (HP:0010808)	2.69251864
24	Febrile seizures (HP:0002373)	2.68928136
25	Congenital primary aphakia (HP:0007707)	2.66264889
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.56111119
27	Sclerocornea (HP:0000647)	2.55956329
28	Type II lissencephaly (HP:0007260)	2.51174642
29	Nephrogenic diabetes insipidus (HP:0009806)	2.50854488
30	Broad-based gait (HP:0002136)	2.49420366
31	Hypoplasia of the fovea (HP:0007750)	2.46502084
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.46502084
33	Keratoconus (HP:0000563)	2.46306872
34	Increased corneal curvature (HP:0100692)	2.46306872
35	Inability to walk (HP:0002540)	2.45727619
36	Furrowed tongue (HP:0000221)	2.44488058
37	Congenital, generalized hypertrichosis (HP:0004540)	2.43937280
38	Polydipsia (HP:0001959)	2.42593312
39	Abnormal drinking behavior (HP:0030082)	2.42593312
40	Clumsiness (HP:0002312)	2.37307273
41	Anencephaly (HP:0002323)	2.37196008
42	Pendular nystagmus (HP:0012043)	2.35224600
43	Abnormality of alanine metabolism (HP:0010916)	2.33470192
44	Hyperalaninemia (HP:0003348)	2.33470192
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.33470192
46	Genital tract atresia (HP:0001827)	2.32625257
47	Lissencephaly (HP:0001339)	2.28485349
48	Absent/shortened dynein arms (HP:0200106)	2.27936580
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27936580
50	Decreased central vision (HP:0007663)	2.27519444
51	Congenital hepatic fibrosis (HP:0002612)	2.27461198
52	Postaxial foot polydactyly (HP:0001830)	2.25739223
53	Oligodactyly (hands) (HP:0001180)	2.25364475
54	Fair hair (HP:0002286)	2.25313372
55	Progressive inability to walk (HP:0002505)	2.23769470
56	Vaginal atresia (HP:0000148)	2.23721979
57	Large for gestational age (HP:0001520)	2.22278174
58	Decreased circulating renin level (HP:0003351)	2.21429710
59	Male pseudohermaphroditism (HP:0000037)	2.19641123
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.19639340
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18694619
62	Renal cortical cysts (HP:0000803)	2.13183540
63	Hemiparesis (HP:0001269)	2.11163741
64	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10941797
65	Focal seizures (HP:0007359)	2.10622680
66	Optic nerve hypoplasia (HP:0000609)	2.10147708
67	Poor coordination (HP:0002370)	2.09325595
68	Concave nail (HP:0001598)	2.08111441
69	Patellar aplasia (HP:0006443)	2.05852917
70	Focal motor seizures (HP:0011153)	2.03670980
71	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02452077
72	Chorioretinal atrophy (HP:0000533)	2.01552523
73	Hypothermia (HP:0002045)	2.00665278
74	Aplasia/Hypoplasia of the patella (HP:0006498)	1.99495502
75	Abnormality of the fovea (HP:0000493)	1.99030433
76	Dialeptic seizures (HP:0011146)	1.94730768
77	Congenital sensorineural hearing impairment (HP:0008527)	1.92042835
78	Bile duct proliferation (HP:0001408)	1.86701154
79	Abnormal biliary tract physiology (HP:0012439)	1.86701154
80	Intestinal atresia (HP:0011100)	1.86215904
81	Absent speech (HP:0001344)	1.85753915
82	Postaxial hand polydactyly (HP:0001162)	1.84746344
83	Atonic seizures (HP:0010819)	1.81760703
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.81541354
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.81541354
86	Polyuria (HP:0000103)	1.80173600
87	Generalized hypopigmentation of hair (HP:0011358)	1.79584373
88	Preaxial hand polydactyly (HP:0001177)	1.79557835
89	Widely spaced teeth (HP:0000687)	1.78794184
90	Drooling (HP:0002307)	1.76567151
91	Pachygyria (HP:0001302)	1.76457364
92	Abnormality of macular pigmentation (HP:0008002)	1.73782732
93	Dandy-Walker malformation (HP:0001305)	1.72367081
94	Cerebellar dysplasia (HP:0007033)	1.70373919
95	Abnormal ciliary motility (HP:0012262)	1.69627249
96	Agitation (HP:0000713)	1.68978431
97	Absence seizures (HP:0002121)	1.67617404
98	Short foot (HP:0001773)	1.67101712
99	Retinitis pigmentosa (HP:0000510)	1.67068873
100	Astigmatism (HP:0000483)	1.66401230

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.53534538
2	BMPR1B	3.09425292
3	ADRBK2	2.94368943
4	ACVR1B	2.72535920
5	TAOK3	2.58490497
6	WNK3	2.45114319
7	NUAK1	2.25201135
8	MAPK13	2.20330254
9	GRK1	2.19837891
10	MAP4K2	2.16566581
11	WNK4	2.15642702
12	MAP3K4	1.97126228
13	INSRR	1.90609589
14	CASK	1.90080549
15	TLK1	1.68837032
16	PINK1	1.62710847
17	ZAK	1.61980807
18	OXSR1	1.58100607
19	STK39	1.52380428
20	MKNK2	1.39376223
21	DAPK2	1.35714172
22	ADRBK1	1.35640296
23	AKT3	1.34932448
24	TNIK	1.27645382
25	NTRK3	1.19269334
26	PAK3	1.17816066
27	MARK1	1.16496562
28	PTK2B	1.07661799
29	STK38L	1.07200547
30	TGFBR1	1.05866221
31	CAMKK2	1.01825542
32	PNCK	1.00659695
33	TXK	0.99150707
34	MAP2K7	0.96148985
35	PRKCG	0.94801367
36	PLK2	0.93819830
37	PRKCE	0.92631875
38	SGK2	0.88072252
39	PIK3CA	0.85485918
40	TRIM28	0.85330005
41	BRSK2	0.83924144
42	TEC	0.77918137
43	DYRK2	0.74642502
44	MAP2K6	0.74276212
45	NTRK2	0.70292392
46	STK11	0.69676582
47	STK3	0.68206467
48	CDK19	0.65737482
49	TIE1	0.62895527
50	CAMK2A	0.62658915
51	VRK1	0.61181331
52	MAPKAPK3	0.60650189
53	SGK223	0.60092950
54	SGK494	0.60092950
55	MKNK1	0.57888877
56	PKN1	0.56061401
57	PLK4	0.53653259
58	MAPK15	0.52927287
59	CAMK1	0.52316339
60	MAPKAPK5	0.52273290
61	IRAK1	0.51198147
62	PRKCQ	0.51060682
63	TRPM7	0.50962815
64	TAF1	0.50819692
65	CSNK1G2	0.50500889
66	PHKG2	0.49827307
67	PHKG1	0.49827307
68	WNK1	0.49174493
69	ERBB3	0.48617873
70	CSNK1G1	0.47653923
71	NLK	0.46933393
72	PRKACA	0.46673459
73	CSNK1A1L	0.46179163
74	BCR	0.45050479
75	MAP2K4	0.44414880
76	CHUK	0.43255586
77	EPHA4	0.43188255
78	PRKG1	0.42890446
79	PIK3CG	0.42009861
80	FGFR2	0.41893343
81	MUSK	0.41503980
82	BCKDK	0.40950562
83	OBSCN	0.40282100
84	DYRK1A	0.40188819
85	SIK2	0.40052873
86	KIT	0.39861143
87	CDK3	0.39203946
88	IKBKB	0.38859460
89	PRKAA2	0.38291540
90	CSNK1D	0.37352171
91	PRKCZ	0.36647695
92	SGK1	0.36350287
93	CSNK1A1	0.36174668
94	CAMK1G	0.35674464
95	RPS6KA5	0.34805176
96	GRK5	0.34638102
97	CAMK4	0.34452264
98	TNK2	0.33779391
99	SYK	0.33666785
100	CSNK1G3	0.33595033

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.01935207
2	Nicotine addiction_Homo sapiens_hsa05033	2.64714763
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.47286981
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.41766849
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.38761267
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.36444565
7	Butanoate metabolism_Homo sapiens_hsa00650	2.22886286
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18052671
9	Caffeine metabolism_Homo sapiens_hsa00232	2.02419086
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98399551
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95616827
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.93295692
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.87171670
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86789982
15	Morphine addiction_Homo sapiens_hsa05032	1.84002934
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.79636223
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79120503
18	Taste transduction_Homo sapiens_hsa04742	1.77980985
19	Olfactory transduction_Homo sapiens_hsa04740	1.63279744
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61642304
21	Homologous recombination_Homo sapiens_hsa03440	1.60540764
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.55552632
23	GABAergic synapse_Homo sapiens_hsa04727	1.52045494
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.48179358
25	Circadian entrainment_Homo sapiens_hsa04713	1.47998925
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.47822653
27	Insulin secretion_Homo sapiens_hsa04911	1.44868102
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.41735588
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38699648
30	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38433165
31	Serotonergic synapse_Homo sapiens_hsa04726	1.37228220
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36547228
33	Protein export_Homo sapiens_hsa03060	1.34368004
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33878259
35	ABC transporters_Homo sapiens_hsa02010	1.31145935
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.27602300
37	Basal transcription factors_Homo sapiens_hsa03022	1.27528050
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23788251
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23722138
40	Salivary secretion_Homo sapiens_hsa04970	1.18079031
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17547371
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17137792
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.12520466
44	Retinol metabolism_Homo sapiens_hsa00830	1.10419529
45	Asthma_Homo sapiens_hsa05310	1.06667608
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06445182
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01861418
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01353550
49	Propanoate metabolism_Homo sapiens_hsa00640	0.99543782
50	Histidine metabolism_Homo sapiens_hsa00340	0.97938583
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97136101
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92893623
53	RNA degradation_Homo sapiens_hsa03018	0.86852456
54	Regulation of autophagy_Homo sapiens_hsa04140	0.85849380
55	Parkinsons disease_Homo sapiens_hsa05012	0.84444769
56	Renin secretion_Homo sapiens_hsa04924	0.82881570
57	Peroxisome_Homo sapiens_hsa04146	0.82548127
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.82171960
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.81067492
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80646909
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80044210
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77980491
63	Amphetamine addiction_Homo sapiens_hsa05031	0.76199923
64	Cholinergic synapse_Homo sapiens_hsa04725	0.75390152
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.71654542
66	Long-term depression_Homo sapiens_hsa04730	0.71604163
67	Cocaine addiction_Homo sapiens_hsa05030	0.70665934
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70099328
69	Gastric acid secretion_Homo sapiens_hsa04971	0.69577675
70	RNA polymerase_Homo sapiens_hsa03020	0.68367992
71	Huntingtons disease_Homo sapiens_hsa05016	0.60247697
72	Alzheimers disease_Homo sapiens_hsa05010	0.60171941
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58597555
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.57776239
75	One carbon pool by folate_Homo sapiens_hsa00670	0.54018939
76	Mineral absorption_Homo sapiens_hsa04978	0.52202866
77	Circadian rhythm_Homo sapiens_hsa04710	0.51513050
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51300737
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49239914
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49140475
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47352771
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46718560
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46164061
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45731889
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45395916
86	Pancreatic secretion_Homo sapiens_hsa04972	0.45016840
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.42692210
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.42684099
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39458715
90	Purine metabolism_Homo sapiens_hsa00230	0.39261110
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.37929240
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.36990137
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35738429
94	Metabolic pathways_Homo sapiens_hsa01100	0.32916368
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32830001
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32775759
97	Fatty acid degradation_Homo sapiens_hsa00071	0.32364200
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31706203
99	Bile secretion_Homo sapiens_hsa04976	0.31361620
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30297601

GRAMD4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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