ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.67126477
2	L-fucose catabolic process (GO:0042355)	4.37939116
3	fucose catabolic process (GO:0019317)	4.37939116
4	L-fucose metabolic process (GO:0042354)	4.37939116
5	DNA double-strand break processing (GO:0000729)	4.23911950
6	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.07655391
7	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.04631479
8	inositol phosphate dephosphorylation (GO:0046855)	4.04631479
9	indolalkylamine metabolic process (GO:0006586)	3.86542160
10	mannosylation (GO:0097502)	3.73289782
11	inositol phosphate catabolic process (GO:0071545)	3.71735334
12	kynurenine metabolic process (GO:0070189)	3.66022554
13	cellular ketone body metabolic process (GO:0046950)	3.58650350
14	DNA deamination (GO:0045006)	3.52967886
15	motile cilium assembly (GO:0044458)	3.51416544
16	ketone body metabolic process (GO:1902224)	3.47836702
17	regulation of meiosis I (GO:0060631)	3.45700905
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.39615652
19	detection of light stimulus involved in visual perception (GO:0050908)	3.39615652
20	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.36721878
21	retinal cone cell development (GO:0046549)	3.31933805
22	exogenous drug catabolic process (GO:0042738)	3.31013287
23	negative regulation of execution phase of apoptosis (GO:1900118)	3.30266811
24	auditory receptor cell stereocilium organization (GO:0060088)	3.22246600
25	respiratory chain complex IV assembly (GO:0008535)	3.18616995
26	positive regulation of action potential (GO:0045760)	3.17418452
27	protein polyglutamylation (GO:0018095)	3.17114669
28	rRNA catabolic process (GO:0016075)	3.15919796
29	atrial cardiac muscle cell action potential (GO:0086014)	3.12221437
30	indole-containing compound metabolic process (GO:0042430)	3.08363795
31	response to pheromone (GO:0019236)	3.06715650
32	reflex (GO:0060004)	3.06404534
33	endoderm formation (GO:0001706)	3.02642442
34	drug catabolic process (GO:0042737)	3.02008553
35	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.00738182
36	polyol catabolic process (GO:0046174)	2.99697675
37	phenylpropanoid metabolic process (GO:0009698)	2.98869718
38	nucleotide transmembrane transport (GO:1901679)	2.95308851
39	ubiquinone biosynthetic process (GO:0006744)	2.95118562
40	glycerophospholipid catabolic process (GO:0046475)	2.95094991
41	cytidine metabolic process (GO:0046087)	2.93791042
42	cytidine catabolic process (GO:0006216)	2.93791042
43	cytidine deamination (GO:0009972)	2.93791042
44	glycosphingolipid biosynthetic process (GO:0006688)	2.93173897
45	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.90097270
46	indole-containing compound catabolic process (GO:0042436)	2.89616355
47	indolalkylamine catabolic process (GO:0046218)	2.89616355
48	tryptophan catabolic process (GO:0006569)	2.89616355
49	maturation of 5.8S rRNA (GO:0000460)	2.89524795
50	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.89466130
51	S-adenosylmethionine metabolic process (GO:0046500)	2.87476423
52	axoneme assembly (GO:0035082)	2.84601313
53	primary amino compound metabolic process (GO:1901160)	2.83370560
54	platelet dense granule organization (GO:0060155)	2.83085404
55	protein prenylation (GO:0018342)	2.82948766
56	prenylation (GO:0097354)	2.82948766
57	methionine biosynthetic process (GO:0009086)	2.82930331
58	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.78976859
59	regulation of memory T cell differentiation (GO:0043380)	2.77779619
60	serotonin metabolic process (GO:0042428)	2.76853620
61	neuronal action potential (GO:0019228)	2.74775826
62	regulation of action potential (GO:0098900)	2.73510158
63	pseudouridine synthesis (GO:0001522)	2.72338189
64	attachment of spindle microtubules to kinetochore (GO:0008608)	2.71022750
65	post-embryonic morphogenesis (GO:0009886)	2.70773334
66	flavonoid metabolic process (GO:0009812)	2.70579143
67	ubiquinone metabolic process (GO:0006743)	2.69905455
68	synaptic transmission, cholinergic (GO:0007271)	2.65744598
69	organelle disassembly (GO:1903008)	2.65432933
70	inner ear receptor stereocilium organization (GO:0060122)	2.64604343
71	recombinational repair (GO:0000725)	2.64169758
72	neuronal action potential propagation (GO:0019227)	2.63913739
73	double-strand break repair via homologous recombination (GO:0000724)	2.63161781
74	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62721294
75	quinone biosynthetic process (GO:1901663)	2.60915962
76	protein-cofactor linkage (GO:0018065)	2.60794874
77	rhodopsin mediated signaling pathway (GO:0016056)	2.60275806
78	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.57958712
79	regulation of mitotic spindle checkpoint (GO:1903504)	2.57400027
80	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.57400027
81	ribonucleoprotein complex disassembly (GO:0032988)	2.57349964
82	male meiosis I (GO:0007141)	2.57266804
83	oxidative demethylation (GO:0070989)	2.56731073
84	tryptophan metabolic process (GO:0006568)	2.56730151
85	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.53869153
86	aspartate family amino acid biosynthetic process (GO:0009067)	2.53820146
87	positive regulation of meiosis (GO:0045836)	2.52695137
88	negative regulation of telomere maintenance (GO:0032205)	2.52472453
89	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47896533
90	metallo-sulfur cluster assembly (GO:0031163)	2.47400806
91	iron-sulfur cluster assembly (GO:0016226)	2.47400806
92	negative regulation of heart rate (GO:0010459)	2.47306233
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46159177
94	magnesium ion transport (GO:0015693)	2.46012805
95	methionine metabolic process (GO:0006555)	2.45399160
96	cytochrome complex assembly (GO:0017004)	2.45333514
97	DNA catabolic process, exonucleolytic (GO:0000738)	2.43400228
98	water-soluble vitamin biosynthetic process (GO:0042364)	2.43127819
99	imidazole-containing compound metabolic process (GO:0052803)	2.41661177
100	GPI anchor metabolic process (GO:0006505)	2.40763838

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.36769704
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13931712
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.04612444
4	VDR_22108803_ChIP-Seq_LS180_Human	2.99768088
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.95296563
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.85479058
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.83567921
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.70629380
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.40756300
10	EWS_26573619_Chip-Seq_HEK293_Human	2.34667902
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23077336
12	FUS_26573619_Chip-Seq_HEK293_Human	2.22264399
13	P300_19829295_ChIP-Seq_ESCs_Human	2.15607801
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13189404
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.10993052
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06075362
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05963145
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02204250
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00545388
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92404722
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75343326
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.74863766
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.67718704
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64148232
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61061677
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60866101
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.60755243
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60696087
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60631585
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57135528
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.56176530
32	STAT3_23295773_ChIP-Seq_U87_Human	1.55749049
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55235929
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55184297
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54869843
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51356885
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.51356885
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.51188223
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50832146
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.49051390
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48255591
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46391398
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45754300
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45754300
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45299995
46	EZH2_22144423_ChIP-Seq_EOC_Human	1.41358867
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40010104
48	TCF4_23295773_ChIP-Seq_U87_Human	1.39446476
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38297854
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37042662
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36702042
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35409505
53	AR_25329375_ChIP-Seq_VCAP_Human	1.34632767
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34290576
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33220897
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32918247
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32918247
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31879817
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31072912
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28913357
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28776647
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27783814
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26692592
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25839765
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25819400
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.25162533
67	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.23517576
68	NCOR_22424771_ChIP-Seq_293T_Human	1.23002692
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22322464
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20374908
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19986159
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19957766
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18052626
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17411667
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16879226
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16648157
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16290369
78	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.15041390
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14456691
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12399325
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12192348
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11150819
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10120273
84	AR_20517297_ChIP-Seq_VCAP_Human	1.05735213
85	GATA3_26560356_Chip-Seq_TH2_Human	1.05716769
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04681951
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.04426982
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03973153
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03464619
90	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02543198
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00488334
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00108334
93	JUN_21703547_ChIP-Seq_K562_Human	0.99670878
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99285116
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99225132
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96162034
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.96055209
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96018972
99	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95906135
100	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.95854203

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.39521840
2	MP0002102_abnormal_ear_morphology	3.16255497
3	MP0006072_abnormal_retinal_apoptosis	2.98487039
4	MP0003646_muscle_fatigue	2.91827075
5	MP0000569_abnormal_digit_pigmentation	2.59536212
6	MP0003195_calcinosis	2.55939928
7	MP0004147_increased_porphyrin_level	2.54227093
8	MP0002138_abnormal_hepatobiliary_system	2.43873581
9	MP0005551_abnormal_eye_electrophysiolog	2.33875980
10	MP0009046_muscle_twitch	2.29444961
11	MP0008057_abnormal_DNA_replication	2.23051036
12	MP0003880_abnormal_central_pattern	2.19408483
13	MP0003890_abnormal_embryonic-extraembry	2.12354756
14	MP0000427_abnormal_hair_cycle	2.09057383
15	MP0008877_abnormal_DNA_methylation	2.08062630
16	MP0001501_abnormal_sleep_pattern	1.96127549
17	MP0003011_delayed_dark_adaptation	1.95448736
18	MP0005645_abnormal_hypothalamus_physiol	1.91576397
19	MP0005253_abnormal_eye_physiology	1.89295092
20	MP0002009_preneoplasia	1.86551859
21	MP0004215_abnormal_myocardial_fiber	1.84634883
22	MP0001485_abnormal_pinna_reflex	1.79602783
23	MP0002876_abnormal_thyroid_physiology	1.75889939
24	MP0002733_abnormal_thermal_nociception	1.74667903
25	MP0004270_analgesia	1.70911560
26	MP0006292_abnormal_olfactory_placode	1.69663364
27	MP0009745_abnormal_behavioral_response	1.68410515
28	MP0004742_abnormal_vestibular_system	1.68316549
29	MP0001486_abnormal_startle_reflex	1.66563905
30	MP0005379_endocrine/exocrine_gland_phen	1.65650341
31	MP0000372_irregular_coat_pigmentation	1.63239981
32	MP0002139_abnormal_hepatobiliary_system	1.63176490
33	MP0001529_abnormal_vocalization	1.56110387
34	MP0008872_abnormal_physiological_respon	1.54557784
35	MP0005646_abnormal_pituitary_gland	1.54250795
36	MP0002837_dystrophic_cardiac_calcinosis	1.50763034
37	MP0005671_abnormal_response_to	1.50079266
38	MP0002735_abnormal_chemical_nociception	1.49856580
39	MP0004133_heterotaxia	1.47603878
40	MP0005386_behavior/neurological_phenoty	1.47131024
41	MP0004924_abnormal_behavior	1.47131024
42	MP0001968_abnormal_touch/_nociception	1.46061256
43	MP0008875_abnormal_xenobiotic_pharmacok	1.43702402
44	MP0003121_genomic_imprinting	1.42895676
45	MP0008058_abnormal_DNA_repair	1.41164990
46	MP0010329_abnormal_lipoprotein_level	1.36701123
47	MP0004043_abnormal_pH_regulation	1.35313941
48	MP0006276_abnormal_autonomic_nervous	1.34332972
49	MP0002272_abnormal_nervous_system	1.31074504
50	MP0003718_maternal_effect	1.30776314
51	MP0008775_abnormal_heart_ventricle	1.26875427
52	MP0001986_abnormal_taste_sensitivity	1.24636673
53	MP0005332_abnormal_amino_acid	1.23711223
54	MP0001970_abnormal_pain_threshold	1.21431845
55	MP0000631_abnormal_neuroendocrine_gland	1.21321211
56	MP0002736_abnormal_nociception_after	1.16918681
57	MP0005167_abnormal_blood-brain_barrier	1.14516228
58	MP0002572_abnormal_emotion/affect_behav	1.13512414
59	MP0003252_abnormal_bile_duct	1.11012845
60	MP0004484_altered_response_of	1.10719783
61	MP0002163_abnormal_gland_morphology	1.09074436
62	MP0009764_decreased_sensitivity_to	1.08381738
63	MP0002160_abnormal_reproductive_system	1.08326218
64	MP0002064_seizures	1.07904373
65	MP0005389_reproductive_system_phenotype	1.07776483
66	MP0004885_abnormal_endolymph	1.07039492
67	MP0009697_abnormal_copulation	1.04144506
68	MP0001764_abnormal_homeostasis	1.02183764
69	MP0005085_abnormal_gallbladder_physiolo	1.01836542
70	MP0001348_abnormal_lacrimal_gland	0.98548726
71	MP0000230_abnormal_systemic_arterial	0.97091053
72	MP0002734_abnormal_mechanical_nocicepti	0.93680794
73	MP0000647_abnormal_sebaceous_gland	0.91464044
74	MP0004085_abnormal_heartbeat	0.91449663
75	MP0002067_abnormal_sensory_capabilities	0.90884170
76	MP0005084_abnormal_gallbladder_morpholo	0.86642102
77	MP0003635_abnormal_synaptic_transmissio	0.85639567
78	MP0002909_abnormal_adrenal_gland	0.85411929
79	MP0005360_urolithiasis	0.84553297
80	MP0005448_abnormal_energy_balance	0.84474510
81	MP0002332_abnormal_exercise_endurance	0.83169378
82	MP0001929_abnormal_gametogenesis	0.82872601
83	MP0001661_extended_life_span	0.81334504
84	MP0002557_abnormal_social/conspecific_i	0.80712234
85	MP0001919_abnormal_reproductive_system	0.80407198
86	MP0005187_abnormal_penis_morphology	0.80275579
87	MP0005266_abnormal_metabolism	0.79623598
88	MP0003137_abnormal_impulse_conducting	0.79404705
89	MP0003879_abnormal_hair_cell	0.78524215
90	MP0001963_abnormal_hearing_physiology	0.78309712
91	MP0001440_abnormal_grooming_behavior	0.78238902
92	MP0000383_abnormal_hair_follicle	0.76997187
93	MP0002693_abnormal_pancreas_physiology	0.75526947
94	MP0004145_abnormal_muscle_electrophysio	0.73973672
95	MP0004142_abnormal_muscle_tone	0.70844278
96	MP0010094_abnormal_chromosome_stability	0.70266923
97	MP0001984_abnormal_olfaction	0.69915096
98	MP0002095_abnormal_skin_pigmentation	0.69547733
99	MP0003937_abnormal_limbs/digits/tail_de	0.69328533
100	MP0005220_abnormal_exocrine_pancreas	0.68792415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.77379931
2	Congenital stationary night blindness (HP:0007642)	4.19884371
3	Pancreatic cysts (HP:0001737)	4.15718382
4	Cerebellar dysplasia (HP:0007033)	3.83186716
5	Methylmalonic acidemia (HP:0002912)	3.67609423
6	True hermaphroditism (HP:0010459)	3.50736450
7	Pancreatic fibrosis (HP:0100732)	3.39510778
8	Abnormality of vitamin B metabolism (HP:0004340)	3.34183308
9	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.16415520
10	Methylmalonic aciduria (HP:0012120)	3.08837787
11	Stomach cancer (HP:0012126)	2.98459262
12	Optic nerve hypoplasia (HP:0000609)	2.91814785
13	Abnormality of the renal cortex (HP:0011035)	2.88381342
14	Hypoplasia of the pons (HP:0012110)	2.84580305
15	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.71749685
16	Lissencephaly (HP:0001339)	2.69656147
17	Homocystinuria (HP:0002156)	2.69393043
18	Abnormality of homocysteine metabolism (HP:0010919)	2.69393043
19	Inability to walk (HP:0002540)	2.69286654
20	Absent speech (HP:0001344)	2.67315637
21	Retinal dysplasia (HP:0007973)	2.64213000
22	Abnormality of the pons (HP:0007361)	2.59864206
23	Gaze-evoked nystagmus (HP:0000640)	2.57028164
24	Medial flaring of the eyebrow (HP:0010747)	2.53006209
25	Abnormal biliary tract physiology (HP:0012439)	2.51390784
26	Bile duct proliferation (HP:0001408)	2.51390784
27	Hyperventilation (HP:0002883)	2.49825660
28	Retinal atrophy (HP:0001105)	2.48650014
29	Abnormality of vitamin metabolism (HP:0100508)	2.46307989
30	Volvulus (HP:0002580)	2.41602546
31	Acute necrotizing encephalopathy (HP:0006965)	2.40462883
32	Anterior segment dysgenesis (HP:0007700)	2.39201747
33	Ketoacidosis (HP:0001993)	2.38681405
34	Occipital encephalocele (HP:0002085)	2.35184262
35	Type I transferrin isoform profile (HP:0003642)	2.32837610
36	Nephronophthisis (HP:0000090)	2.31349037
37	Acute encephalopathy (HP:0006846)	2.30602814
38	Congenital sensorineural hearing impairment (HP:0008527)	2.29434400
39	Congenital primary aphakia (HP:0007707)	2.29369835
40	Mitochondrial inheritance (HP:0001427)	2.26742750
41	Gait imbalance (HP:0002141)	2.23388516
42	Increased CSF lactate (HP:0002490)	2.23304669
43	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23133190
44	Renal cortical cysts (HP:0000803)	2.22401651
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21598068
46	Hyperglycinemia (HP:0002154)	2.21202349
47	Molar tooth sign on MRI (HP:0002419)	2.21079406
48	Abnormality of midbrain morphology (HP:0002418)	2.21079406
49	Severe combined immunodeficiency (HP:0004430)	2.20870953
50	Colon cancer (HP:0003003)	2.20237040
51	Abnormality of methionine metabolism (HP:0010901)	2.19692853
52	Hypothermia (HP:0002045)	2.17193653
53	Ketosis (HP:0001946)	2.17034355
54	Abnormality of serine family amino acid metabolism (HP:0010894)	2.16706807
55	Abnormality of glycine metabolism (HP:0010895)	2.16706807
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16233527
57	Hyperglycinuria (HP:0003108)	2.15862779
58	Focal motor seizures (HP:0011153)	2.14120794
59	Poor coordination (HP:0002370)	2.14042209
60	Abnormality of the renal medulla (HP:0100957)	2.07945565
61	Increased corneal curvature (HP:0100692)	2.07214389
62	Keratoconus (HP:0000563)	2.07214389
63	Febrile seizures (HP:0002373)	2.07161463
64	Sclerocornea (HP:0000647)	2.05835080
65	Progressive inability to walk (HP:0002505)	2.04892174
66	Hypoplasia of the fovea (HP:0007750)	2.03542184
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.03542184
68	Progressive macrocephaly (HP:0004481)	2.03477363
69	Cystic liver disease (HP:0006706)	2.03408167
70	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.99148277
71	Proximal tubulopathy (HP:0000114)	1.99142394
72	Genital tract atresia (HP:0001827)	1.96862436
73	Birth length less than 3rd percentile (HP:0003561)	1.96477063
74	Attenuation of retinal blood vessels (HP:0007843)	1.96399960
75	Broad-based gait (HP:0002136)	1.93454369
76	Vaginal atresia (HP:0000148)	1.92996371
77	Intestinal atresia (HP:0011100)	1.92887475
78	Nephrogenic diabetes insipidus (HP:0009806)	1.90837887
79	Severe muscular hypotonia (HP:0006829)	1.90165804
80	Protruding tongue (HP:0010808)	1.89531912
81	Congenital hepatic fibrosis (HP:0002612)	1.89202311
82	Abnormal protein glycosylation (HP:0012346)	1.86956742
83	Abnormal glycosylation (HP:0012345)	1.86956742
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.86956742
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.86956742
86	Abnormality of the vitreous humor (HP:0004327)	1.83893374
87	Chronic hepatic failure (HP:0100626)	1.83868736
88	Hepatic necrosis (HP:0002605)	1.82641020
89	Tubular atrophy (HP:0000092)	1.81038417
90	Hepatocellular necrosis (HP:0001404)	1.79681895
91	Male pseudohermaphroditism (HP:0000037)	1.79286290
92	Thyroiditis (HP:0100646)	1.79051664
93	Abnormality of alanine metabolism (HP:0010916)	1.78404191
94	Hyperalaninemia (HP:0003348)	1.78404191
95	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78404191
96	Abnormality of the fovea (HP:0000493)	1.78075639
97	Short chin (HP:0000331)	1.78031626
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77907998
99	Abnormality of serum amino acid levels (HP:0003112)	1.77395070
100	Concave nail (HP:0001598)	1.77119088

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.82190019
2	ZAK	3.64562034
3	TAOK3	3.24455248
4	GRK1	3.13428572
5	ACVR1B	3.01522231
6	TRIM28	2.95102282
7	MAP4K2	2.85332076
8	TESK2	2.77504890
9	ADRBK2	2.64389503
10	TXK	2.61350333
11	WNK3	2.53049987
12	MAP3K4	2.21920897
13	STK16	2.16877911
14	CASK	2.09302617
15	BMPR1B	2.05156506
16	MAP2K7	1.69580485
17	SIK2	1.68188698
18	BCR	1.62102306
19	MST4	1.50892388
20	TLK1	1.50317772
21	NUAK1	1.49194431
22	OXSR1	1.46744856
23	MAPKAPK3	1.46360062
24	SIK3	1.42748889
25	NEK1	1.27287398
26	ERBB3	1.22858130
27	DAPK2	1.18471647
28	KDR	1.16458220
29	PAK3	1.16357942
30	CAMKK2	1.13239310
31	MAPK13	1.12344865
32	STK39	1.09668996
33	ADRBK1	1.09018083
34	WNK4	1.08050960
35	CSNK1G2	0.99076274
36	GRK7	0.97456086
37	BRSK2	0.97102521
38	STK3	0.92706404
39	PRKCE	0.91413023
40	PINK1	0.90421373
41	STK38L	0.90048921
42	PLK4	0.89138275
43	MKNK2	0.88460991
44	VRK1	0.84161278
45	PRKCG	0.83578565
46	PIK3CA	0.83367790
47	LATS1	0.80917042
48	DAPK1	0.80160605
49	NLK	0.78692443
50	CSNK1G1	0.78424458
51	CAMK2A	0.77350998
52	TRPM7	0.76933415
53	ITK	0.75767824
54	PLK2	0.75516191
55	EIF2AK3	0.73542391
56	PNCK	0.72858423
57	SRPK1	0.72082368
58	PTK2B	0.71743892
59	CHEK2	0.68734542
60	AKT3	0.68029473
61	MAP3K5	0.67319621
62	INSRR	0.66957778
63	MELK	0.65711833
64	CSNK1A1L	0.65037593
65	NTRK2	0.63968290
66	IRAK1	0.63682409
67	CCNB1	0.62082428
68	LIMK1	0.59780319
69	MAP2K6	0.59592364
70	TGFBR1	0.58723908
71	STK24	0.58491909
72	CSNK1G3	0.58266689
73	CAMK2B	0.57090529
74	MARK1	0.56322093
75	PLK3	0.55219444
76	CDK19	0.55185467
77	PRKCQ	0.54659576
78	MAP2K4	0.47604846
79	TNIK	0.42679832
80	NEK6	0.41812684
81	CAMK2D	0.41803642
82	TAF1	0.40648604
83	SYK	0.40136784
84	PLK1	0.39451050
85	MINK1	0.38342465
86	TEC	0.38154366
87	MAPK7	0.38018424
88	IGF1R	0.36155885
89	CDK3	0.35921523
90	RPS6KA5	0.35740979
91	PRKACA	0.34856104
92	CSNK1D	0.34175900
93	IRAK2	0.31280253
94	BMX	0.30828892
95	PRKCA	0.30322519
96	ROCK1	0.30251932
97	IKBKE	0.29297931
98	TIE1	0.29260339
99	MKNK1	0.29237051
100	ABL1	0.27577776

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.47190534
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.02988607
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.76136330
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43432528
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32566717
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.30209791
7	Protein export_Homo sapiens_hsa03060	2.16570747
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.15245577
9	Nicotine addiction_Homo sapiens_hsa05033	2.11645785
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.04086779
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.98249508
12	Sulfur metabolism_Homo sapiens_hsa00920	1.96235281
13	Propanoate metabolism_Homo sapiens_hsa00640	1.90633825
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.90539663
15	Retinol metabolism_Homo sapiens_hsa00830	1.83555641
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.81945340
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78762003
18	Caffeine metabolism_Homo sapiens_hsa00232	1.76869478
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.68935380
20	Homologous recombination_Homo sapiens_hsa03440	1.61721703
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60943170
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.59462869
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.58356085
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.57652870
25	Olfactory transduction_Homo sapiens_hsa04740	1.54214699
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.49591851
27	Taste transduction_Homo sapiens_hsa04742	1.46147008
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41702678
29	RNA degradation_Homo sapiens_hsa03018	1.33056197
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32998599
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.30327928
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.26005565
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25663741
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23639291
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23634649
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23592660
37	Morphine addiction_Homo sapiens_hsa05032	1.21434858
38	GABAergic synapse_Homo sapiens_hsa04727	1.16092449
39	Basal transcription factors_Homo sapiens_hsa03022	1.16008519
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14991050
41	Serotonergic synapse_Homo sapiens_hsa04726	1.13632815
42	Histidine metabolism_Homo sapiens_hsa00340	1.13414369
43	Peroxisome_Homo sapiens_hsa04146	1.09593251
44	One carbon pool by folate_Homo sapiens_hsa00670	1.07399892
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06300842
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06175763
47	Regulation of autophagy_Homo sapiens_hsa04140	1.04907666
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.04008461
49	RNA polymerase_Homo sapiens_hsa03020	1.03344457
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.02109983
51	Circadian entrainment_Homo sapiens_hsa04713	1.01312156
52	Steroid biosynthesis_Homo sapiens_hsa00100	1.01262077
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99454930
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97085144
55	Proteasome_Homo sapiens_hsa03050	0.97022760
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.94060171
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88039651
58	ABC transporters_Homo sapiens_hsa02010	0.86099724
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85010812
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79261029
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.76516491
62	Parkinsons disease_Homo sapiens_hsa05012	0.75769589
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75336642
64	Salivary secretion_Homo sapiens_hsa04970	0.73032568
65	Mineral absorption_Homo sapiens_hsa04978	0.72964157
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.71514102
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.69117857
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68923660
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68100546
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66562221
71	Metabolic pathways_Homo sapiens_hsa01100	0.61479284
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60345625
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60312263
74	Alzheimers disease_Homo sapiens_hsa05010	0.59741820
75	Insulin secretion_Homo sapiens_hsa04911	0.59453506
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.59176070
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.58443916
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.55149084
79	Purine metabolism_Homo sapiens_hsa00230	0.54794006
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54352852
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53979457
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.53669059
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49911123
84	Huntingtons disease_Homo sapiens_hsa05016	0.49713827
85	Circadian rhythm_Homo sapiens_hsa04710	0.47903095
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45977174
87	Amphetamine addiction_Homo sapiens_hsa05031	0.45539576
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44961513
89	Renin secretion_Homo sapiens_hsa04924	0.38702089
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38439311
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36041440
92	Asthma_Homo sapiens_hsa05310	0.35858478
93	p53 signaling pathway_Homo sapiens_hsa04115	0.35521508
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35304352
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.35040501
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34527629
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32382680
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30564683
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.28018550
100	Gastric acid secretion_Homo sapiens_hsa04971	0.26740812

GRAMD4P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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