GRAPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.57759534
2regulation of B cell receptor signaling pathway (GO:0050855)5.90261760
3negative regulation of cell killing (GO:0031342)5.68385211
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68385211
5B cell receptor signaling pathway (GO:0050853)5.47547584
6negative thymic T cell selection (GO:0045060)5.27925695
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24311304
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21950604
9negative T cell selection (GO:0043383)5.15509279
10antigen processing and presentation of endogenous antigen (GO:0019883)5.10660742
11positive thymic T cell selection (GO:0045059)5.07980009
12regulation of gamma-delta T cell activation (GO:0046643)4.91111388
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80281421
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80153037
15regulation of gamma-delta T cell differentiation (GO:0045586)4.77103261
16thymic T cell selection (GO:0045061)4.66364280
17positive T cell selection (GO:0043368)4.65841669
18T cell selection (GO:0045058)4.45587217
19positive regulation of B cell differentiation (GO:0045579)4.28711594
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24323253
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24323253
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.24323253
23modulation by symbiont of host immune response (GO:0052553)4.24323253
24positive regulation by symbiont of host defense response (GO:0052509)4.24323253
25modulation by symbiont of host defense response (GO:0052031)4.24323253
26T cell migration (GO:0072678)4.23528779
27regulation of B cell differentiation (GO:0045577)4.19678159
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.14235999
29response to interleukin-15 (GO:0070672)4.06258813
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.97557019
31positive regulation of granulocyte differentiation (GO:0030854)3.89240644
32leukocyte aggregation (GO:0070486)3.86392134
33detection of other organism (GO:0098543)3.78225109
34detection of bacterium (GO:0016045)3.76628766
35B cell homeostasis (GO:0001782)3.75528812
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.75398340
37regulation of interferon-beta biosynthetic process (GO:0045357)3.68149436
38germinal center formation (GO:0002467)3.67997550
39tolerance induction (GO:0002507)3.67182701
40histone H3-K36 demethylation (GO:0070544)3.59514745
41macrophage activation involved in immune response (GO:0002281)3.54721782
42cellular response to interleukin-15 (GO:0071350)3.51604050
43negative regulation of T cell mediated immunity (GO:0002710)3.50946342
44regulation of alpha-beta T cell proliferation (GO:0046640)3.48490783
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.47796250
46response to muramyl dipeptide (GO:0032495)3.45452385
47antigen receptor-mediated signaling pathway (GO:0050851)3.44333525
48negative regulation of erythrocyte differentiation (GO:0045647)3.40770323
49cellular extravasation (GO:0045123)3.28093786
50T cell homeostasis (GO:0043029)3.27150143
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23700760
52negative regulation of leukocyte mediated immunity (GO:0002704)3.18002165
53lymphocyte homeostasis (GO:0002260)3.14797568
54response to type I interferon (GO:0034340)3.13757924
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13262676
56regulation of T cell tolerance induction (GO:0002664)3.11826280
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09504165
58cellular response to type I interferon (GO:0071357)3.09433350
59type I interferon signaling pathway (GO:0060337)3.09433350
60positive regulation of Rap GTPase activity (GO:0032854)3.08159817
61B cell proliferation (GO:0042100)3.04748836
62immunoglobulin mediated immune response (GO:0016064)3.04590013
63detection of external biotic stimulus (GO:0098581)3.03848134
64regulation of granulocyte differentiation (GO:0030852)3.03283320
65NIK/NF-kappaB signaling (GO:0038061)3.01226101
66natural killer cell differentiation (GO:0001779)2.98644778
67regulation of histone H3-K27 methylation (GO:0061085)2.98451180
68regulation of necroptotic process (GO:0060544)2.96481503
69negative regulation of interleukin-12 production (GO:0032695)2.94346447
70defense response to protozoan (GO:0042832)2.93666491
71interferon-gamma production (GO:0032609)2.92955692
72regulation of interleukin-2 biosynthetic process (GO:0045076)2.90926693
73T cell receptor signaling pathway (GO:0050852)2.90346521
74activated T cell proliferation (GO:0050798)2.89497613
75myeloid cell activation involved in immune response (GO:0002275)2.88448473
76regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88241523
77positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86238848
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85846931
79interferon-gamma-mediated signaling pathway (GO:0060333)2.82832795
80negative regulation of innate immune response (GO:0045824)2.82333227
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81779307
82negative regulation of T-helper cell differentiation (GO:0045623)2.81779307
83mucosal-associated lymphoid tissue development (GO:0048537)2.81752648
84Peyers patch development (GO:0048541)2.81752648
85regulation of tolerance induction (GO:0002643)2.79495404
86antigen processing and presentation via MHC class Ib (GO:0002475)2.79233557
87positive regulation of interleukin-2 production (GO:0032743)2.78938186
88positive regulation of B cell activation (GO:0050871)2.78106426
89mast cell activation (GO:0045576)2.76011901
90myeloid dendritic cell activation (GO:0001773)2.75848505
91positive regulation of isotype switching (GO:0045830)2.75413606
92regulation of MHC class I biosynthetic process (GO:0045343)2.74639647
93neutrophil activation involved in immune response (GO:0002283)2.74059850
94regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72847212
95response to protozoan (GO:0001562)2.72689638
96regulation of antigen processing and presentation (GO:0002577)2.70330930
97response to host immune response (GO:0052572)2.70155383
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70155383
99negative regulation of phagocytosis (GO:0050765)2.69932767
100leukocyte homeostasis (GO:0001776)2.69919885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.26868374
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.77465487
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.35152942
4MYC_22102868_ChIP-Seq_BL_Human4.10818527
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30221531
6VDR_21846776_ChIP-Seq_THP-1_Human3.17902854
7RUNX_20019798_ChIP-Seq_JUKART_Human3.13030367
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.98518398
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87316781
10MAF_26560356_Chip-Seq_TH1_Human2.85274288
11MYB_26560356_Chip-Seq_TH2_Human2.81752945
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73830659
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71384267
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.61169539
15MYB_26560356_Chip-Seq_TH1_Human2.59769051
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58544956
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56199958
18UTX_26944678_Chip-Seq_JUKART_Human2.53932110
19VDR_24763502_ChIP-Seq_THP-1_Human2.44207294
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.42772332
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39959979
22TCF7_22412390_ChIP-Seq_EML_Mouse2.36955298
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35890024
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33504575
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32664532
26SCL_19346495_ChIP-Seq_HPC-7_Human2.32523648
27MAF_26560356_Chip-Seq_TH2_Human2.31215309
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.29945263
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.22878212
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21183755
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15057445
32SPI1_23547873_ChIP-Seq_NB4_Human2.14786417
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14735836
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13959485
35RUNX1_22412390_ChIP-Seq_EML_Mouse2.12266465
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11828069
37SPI1_23127762_ChIP-Seq_K562_Human2.06931068
38KDM2B_26808549_Chip-Seq_DND41_Human2.01706217
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99927054
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92636062
41CIITA_25753668_ChIP-Seq_RAJI_Human1.90984860
42GATA3_27048872_Chip-Seq_THYMUS_Human1.87740052
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80021299
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75101457
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69150417
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63907720
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62228318
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.62220806
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49107360
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.48114406
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.47252560
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42504510
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39991241
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36581177
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35458950
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34995221
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33811489
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33800355
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32585606
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30101606
61GATA3_26560356_Chip-Seq_TH2_Human1.29746712
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.29659563
63LXR_22292898_ChIP-Seq_THP-1_Human1.27888676
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25928226
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.21974939
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21765495
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20839585
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18191427
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.16777772
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15962576
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14966804
72PU_27001747_Chip-Seq_BMDM_Mouse1.13491326
73VDR_24787735_ChIP-Seq_THP-1_Human1.11212991
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09439633
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09434880
76BCOR_27268052_Chip-Seq_Bcells_Human1.07705406
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07264535
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07120548
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05189999
80GATA1_19941826_ChIP-Seq_K562_Human1.04371612
81NCOR1_26117541_ChIP-Seq_K562_Human1.03607247
82BCL6_27268052_Chip-Seq_Bcells_Human1.03578975
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02756035
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00215664
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00029536
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98813267
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98079698
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97813263
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97358009
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96329744
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94834843
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.92391209
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91706282
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89092670
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86316176
96P68_20966046_ChIP-Seq_HELA_Human0.84746492
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83189725
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79831250
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79220615
100P300_27268052_Chip-Seq_Bcells_Human0.78244397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.21380846
2MP0001835_abnormal_antigen_presentation3.66370373
3MP0001800_abnormal_humoral_immune3.48577529
4MP0003436_decreased_susceptibility_to3.30482151
5MP0000685_abnormal_immune_system3.27485761
6MP0003303_peritoneal_inflammation3.14348197
7MP0005387_immune_system_phenotype3.11683878
8MP0001790_abnormal_immune_system3.11683878
9MP0005000_abnormal_immune_tolerance2.84537000
10MP0005671_abnormal_response_to2.83513808
11MP0003300_gastrointestinal_ulcer2.77075073
12MP0003724_increased_susceptibility_to2.76188808
13MP0002452_abnormal_antigen_presenting2.71196196
14MP0002420_abnormal_adaptive_immunity2.69905112
15MP0002723_abnormal_immune_serum2.68819378
16MP0001819_abnormal_immune_cell2.65095368
17MP0002398_abnormal_bone_marrow2.50353787
18MP0002396_abnormal_hematopoietic_system2.49824520
19MP0002419_abnormal_innate_immunity2.34542715
20MP0005025_abnormal_response_to2.34492739
21MP0000716_abnormal_immune_system2.25338347
22MP0009333_abnormal_splenocyte_physiolog2.17701704
23MP0000703_abnormal_thymus_morphology2.14545396
24MP0000689_abnormal_spleen_morphology2.10144675
25MP0002405_respiratory_system_inflammati2.07650487
26MP0004381_abnormal_hair_follicle2.00990256
27MP0002722_abnormal_immune_system2.00779397
28MP0010155_abnormal_intestine_physiology1.92815721
29MP0002138_abnormal_hepatobiliary_system1.88398635
30MP0001873_stomach_inflammation1.88254133
31MP0008260_abnormal_autophagy1.86837115
32MP0009785_altered_susceptibility_to1.85346952
33MP0002429_abnormal_blood_cell1.84814109
34MP0005310_abnormal_salivary_gland1.78014301
35MP0002166_altered_tumor_susceptibility1.73247107
36MP0005464_abnormal_platelet_physiology1.73119876
37MP0004947_skin_inflammation1.67829421
38MP0003866_abnormal_defecation1.66965697
39MP0000465_gastrointestinal_hemorrhage1.61008938
40MP0008057_abnormal_DNA_replication1.60226573
41MP0003828_pulmonary_edema1.57005466
42MP0002148_abnormal_hypersensitivity_rea1.56248195
43MP0001845_abnormal_inflammatory_respons1.53624701
44MP0002009_preneoplasia1.53399607
45MP0004808_abnormal_hematopoietic_stem1.47412672
46MP0001986_abnormal_taste_sensitivity1.44125401
47MP0003172_abnormal_lysosome_physiology1.36735990
48MP0002933_joint_inflammation1.34794070
49MP0003091_abnormal_cell_migration1.29391964
50MP0009278_abnormal_bone_marrow1.28993261
51MP0003191_abnormal_cellular_cholesterol1.28097434
52MP0002132_abnormal_respiratory_system1.27331563
53MP0001533_abnormal_skeleton_physiology1.26348118
54MP0005075_abnormal_melanosome_morpholog1.11697972
55MP0000858_altered_metastatic_potential1.11158537
56MP0005451_abnormal_body_composition1.09508912
57MP0006082_CNS_inflammation1.08486098
58MP0002006_tumorigenesis1.07310539
59MP0008469_abnormal_protein_level1.06516543
60MP0001851_eye_inflammation1.04652644
61MP0002019_abnormal_tumor_incidence0.99032592
62MP0002998_abnormal_bone_remodeling0.98040807
63MP0001853_heart_inflammation0.96774366
64MP0000490_abnormal_crypts_of0.93464842
65MP0005397_hematopoietic_system_phenotyp0.91624176
66MP0001545_abnormal_hematopoietic_system0.91624176
67MP0005076_abnormal_cell_differentiation0.91062843
68MP0000015_abnormal_ear_pigmentation0.90937576
69MP0003045_fibrosis0.90352135
70MP0000249_abnormal_blood_vessel0.89156802
71MP0003183_abnormal_peptide_metabolism0.86826806
72MP0004883_abnormal_blood_vessel0.86000145
73MP0002928_abnormal_bile_duct0.79546338
74MP0001348_abnormal_lacrimal_gland0.77841849
75MP0003279_aneurysm0.77689200
76MP0001663_abnormal_digestive_system0.74270938
77MP0005621_abnormal_cell_physiology0.72551238
78MP0008961_abnormal_basal_metabolism0.71959240
79MP0009764_decreased_sensitivity_to0.71560965
80MP0004510_myositis0.70381840
81MP0000767_abnormal_smooth_muscle0.67909074
82MP0009115_abnormal_fat_cell0.66843208
83MP0005058_abnormal_lysosome_morphology0.64246953
84MP0005167_abnormal_blood-brain_barrier0.58316460
85MP0003448_altered_tumor_morphology0.57632096
86MP0004130_abnormal_muscle_cell0.57182523
87MP0005409_darkened_coat_color0.55186252
88MP0000313_abnormal_cell_death0.55019455
89MP0002332_abnormal_exercise_endurance0.54550685
90MP0009763_increased_sensitivity_to0.54225771
91MP0002136_abnormal_kidney_physiology0.53356926
92MP0001879_abnormal_lymphatic_vessel0.52444556
93MP0008874_decreased_physiological_sensi0.52267511
94MP0001915_intracranial_hemorrhage0.51024072
95MP0003221_abnormal_cardiomyocyte_apopto0.50433969
96MP0000371_diluted_coat_color0.50380126
97MP0005166_decreased_susceptibility_to0.49965616
98MP0005164_abnormal_response_to0.49178236
99MP0003077_abnormal_cell_cycle0.47611044
100MP0000609_abnormal_liver_physiology0.47554937

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.32476740
2Panhypogammaglobulinemia (HP:0003139)5.15150479
3Agammaglobulinemia (HP:0004432)5.02245493
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.88595919
5Recurrent bacterial skin infections (HP:0005406)4.48177218
6Colitis (HP:0002583)4.36602069
7Meningitis (HP:0001287)4.28459593
8Recurrent fungal infections (HP:0002841)4.23927789
9Recurrent abscess formation (HP:0002722)4.22453183
10Recurrent viral infections (HP:0004429)4.21678039
11Spontaneous hematomas (HP:0007420)3.96283349
12Cellulitis (HP:0100658)3.94968897
13T lymphocytopenia (HP:0005403)3.86845212
14Recurrent cutaneous fungal infections (HP:0011370)3.84656888
15Chronic mucocutaneous candidiasis (HP:0002728)3.84656888
16Mediastinal lymphadenopathy (HP:0100721)3.84058703
17Pustule (HP:0200039)3.69963529
18Inflammation of the large intestine (HP:0002037)3.69666034
19Gastrointestinal inflammation (HP:0004386)3.66029048
20Abnormality of T cell number (HP:0011839)3.63918310
21Gastrointestinal stroma tumor (HP:0100723)3.61512993
22Myositis (HP:0100614)3.55381269
23Lymphopenia (HP:0001888)3.50141076
24Vasculitis (HP:0002633)3.40629159
25Recurrent skin infections (HP:0001581)3.39122489
26Abnormality of macrophages (HP:0004311)3.36599550
27Abnormality of T cells (HP:0002843)3.35668277
28IgM deficiency (HP:0002850)3.33790305
29Verrucae (HP:0200043)3.32900355
30Papilloma (HP:0012740)3.32900355
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.27417974
32Recurrent bronchitis (HP:0002837)3.19690133
33Abnormality of the fingertips (HP:0001211)3.17121265
34Elevated erythrocyte sedimentation rate (HP:0003565)3.15959227
35Recurrent gram-negative bacterial infections (HP:0005420)3.13970443
36Gastrointestinal infarctions (HP:0005244)3.13718073
37Viral hepatitis (HP:0006562)3.10987018
38Encephalitis (HP:0002383)3.09042726
39Prolonged bleeding time (HP:0003010)3.01508323
40Recurrent sinusitis (HP:0011108)2.94112195
41Retrobulbar optic neuritis (HP:0100654)2.93552520
42Optic neuritis (HP:0100653)2.93552520
43Abnormality of T cell physiology (HP:0011840)2.93274128
44Chest pain (HP:0100749)2.91447327
45Orchitis (HP:0100796)2.90557532
46Increased IgE level (HP:0003212)2.89031888
47Stomatitis (HP:0010280)2.88863289
48Obstructive lung disease (HP:0006536)2.85334265
49Chronic obstructive pulmonary disease (HP:0006510)2.85334265
50Granulocytopenia (HP:0001913)2.82252142
51Basal cell carcinoma (HP:0002671)2.77975337
52Osteomyelitis (HP:0002754)2.74619174
53Epistaxis (HP:0000421)2.73970492
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71797830
55Hypochromic anemia (HP:0001931)2.71445248
56IgA deficiency (HP:0002720)2.70085786
57Emphysema (HP:0002097)2.63995740
58Gingivitis (HP:0000230)2.60565878
59Hypoplasia of the thymus (HP:0000778)2.53808981
60Pulmonary infiltrates (HP:0002113)2.47396455
61IgG deficiency (HP:0004315)2.47070967
62Fatigue (HP:0012378)2.46217545
63Autoimmune hemolytic anemia (HP:0001890)2.43385733
64Restrictive lung disease (HP:0002091)2.42747161
65Chronic diarrhea (HP:0002028)2.41854062
66Papilledema (HP:0001085)2.41801063
67Slow saccadic eye movements (HP:0000514)2.40686474
68Hypochromic microcytic anemia (HP:0004840)2.36541483
69Lymphoma (HP:0002665)2.34702633
70Hemoptysis (HP:0002105)2.33645021
71Leukocytosis (HP:0001974)2.31998501
72Hematochezia (HP:0002573)2.29369286
73Arterial thrombosis (HP:0004420)2.27787506
74Sepsis (HP:0100806)2.25100728
75Recurrent lower respiratory tract infections (HP:0002783)2.24774610
76Eosinophilia (HP:0001880)2.24388925
77Severe combined immunodeficiency (HP:0004430)2.23586545
78Recurrent pneumonia (HP:0006532)2.19527611
79Microcytic anemia (HP:0001935)2.15457253
80Gingival bleeding (HP:0000225)2.14891360
81Urticaria (HP:0001025)2.13265674
82Abnormality of B cell number (HP:0010975)2.11145451
83Teleangiectasia of the skin (HP:0100585)2.05595587
84Pulmonary embolism (HP:0002204)2.03865447
85Abnormality of eosinophils (HP:0001879)2.03848578
86Abnormality of the peritoneum (HP:0002585)2.03599699
87Keratoconjunctivitis sicca (HP:0001097)2.03412321
88Skin ulcer (HP:0200042)1.93866654
89Chronic otitis media (HP:0000389)1.93761902
90Hepatitis (HP:0012115)1.93066208
91Thrombocytosis (HP:0001894)1.90662848
92Autoimmune thrombocytopenia (HP:0001973)1.89581772
93Keratoconjunctivitis (HP:0001096)1.89219174
94Increased IgM level (HP:0003496)1.88886547
95Acute hepatic failure (HP:0006554)1.87833839
96Abnormality of the pleura (HP:0002103)1.84153521
97B lymphocytopenia (HP:0010976)1.80170330
98Subacute progressive viral hepatitis (HP:0006572)1.79750288
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.79709522
100Combined immunodeficiency (HP:0005387)1.78452729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.98970995
2RIPK43.60843277
3PRPF4B3.34734700
4BLK3.12021328
5MAP3K102.92559033
6MAP3K132.90522227
7FES2.31404696
8ERN12.28890669
9BTK2.27441910
10MAP3K142.25412943
11CDK122.24456189
12TYK22.16710818
13SYK1.94640386
14IRAK41.91976044
15ZAP701.77551073
16JAK31.77350445
17ITK1.76285756
18CSK1.75043357
19MAP2K31.73293354
20GRK61.67105913
21TEC1.64103239
22TXK1.63623582
23TRIB31.61631057
24SIK21.60958734
25IKBKE1.60447499
26HCK1.56722356
27TNK21.48470552
28JAK11.35962446
29CDK41.32558219
30MAP3K71.28525740
31LYN1.27218800
32SMG11.25168308
33TAOK31.22313975
34LCK1.20094085
35SIK31.19378156
36FGFR41.18410121
37PASK1.16103274
38CSF1R1.15727867
39CDC42BPA1.15459757
40NLK1.13450124
41MARK21.12666252
42TBK11.10612246
43TIE11.09923311
44MARK31.06594790
45IKBKB1.05498196
46FGFR31.02790852
47BRD40.99669077
48MAPK110.95586082
49STK100.94720705
50MAPK120.94250937
51MELK0.93363961
52PDK10.88192041
53JAK20.87741628
54PRKCQ0.85893124
55MAPK70.85855442
56FGR0.84962969
57TGFBR20.79674499
58EPHB10.78462978
59BMPR20.77677832
60EEF2K0.75715738
61PIM10.74625554
62KIT0.73547591
63CAMKK10.71366700
64MAP3K10.69172717
65HIPK20.69117674
66SIK10.68347904
67ICK0.64326506
68CAMKK20.62633021
69PTK2B0.62573823
70PDPK10.62298010
71KDR0.61601022
72CHUK0.59966623
73YES10.56209050
74MAP3K30.54170970
75WNK10.53859826
76CDK60.51751056
77PRKD20.51181990
78KSR20.51013943
79CDK90.50846417
80TESK20.50271538
81SGK30.48832079
82TRPM70.48347330
83STK40.46678959
84SGK20.45018526
85TAOK10.43852548
86PIK3CG0.41670820
87RPS6KL10.40693563
88RPS6KC10.40693563
89LRRK20.40300188
90MAP3K110.40064670
91NEK90.38977569
92PTK60.38570040
93FYN0.37928913
94PKN20.37575823
95PRKCH0.37175194
96CAMK40.36333639
97RPS6KA60.34499704
98TGFBR10.30135484
99TYRO30.29609707
100MAP3K80.29444324

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.52691020
2B cell receptor signaling pathway_Homo sapiens_hsa046623.13720725
3Allograft rejection_Homo sapiens_hsa053302.59593077
4Graft-versus-host disease_Homo sapiens_hsa053322.47422623
5Autoimmune thyroid disease_Homo sapiens_hsa053202.47364414
6Leishmaniasis_Homo sapiens_hsa051402.34254766
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.29451558
8Osteoclast differentiation_Homo sapiens_hsa043802.19206441
9T cell receptor signaling pathway_Homo sapiens_hsa046602.18537505
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.16455230
11Acute myeloid leukemia_Homo sapiens_hsa052211.95617576
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92288430
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89152554
14Measles_Homo sapiens_hsa051621.78559523
15Type I diabetes mellitus_Homo sapiens_hsa049401.77681655
16Staphylococcus aureus infection_Homo sapiens_hsa051501.75829792
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75286925
18Viral myocarditis_Homo sapiens_hsa054161.64311400
19Hematopoietic cell lineage_Homo sapiens_hsa046401.63894692
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61550906
21Non-small cell lung cancer_Homo sapiens_hsa052231.61156923
22Toxoplasmosis_Homo sapiens_hsa051451.60361175
23Herpes simplex infection_Homo sapiens_hsa051681.59241390
24Asthma_Homo sapiens_hsa053101.58730325
25Antigen processing and presentation_Homo sapiens_hsa046121.56452867
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55145946
27Influenza A_Homo sapiens_hsa051641.54286067
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49249927
29Hepatitis B_Homo sapiens_hsa051611.47601121
30Tuberculosis_Homo sapiens_hsa051521.47253201
31Chronic myeloid leukemia_Homo sapiens_hsa052201.41830123
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.33688273
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32537733
34TNF signaling pathway_Homo sapiens_hsa046681.25609599
35Chemokine signaling pathway_Homo sapiens_hsa040621.23292077
36Pancreatic cancer_Homo sapiens_hsa052121.22452593
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15952329
38Epstein-Barr virus infection_Homo sapiens_hsa051691.12961376
39Apoptosis_Homo sapiens_hsa042101.12537560
40Other glycan degradation_Homo sapiens_hsa005111.11073518
41Viral carcinogenesis_Homo sapiens_hsa052031.10153456
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.09562995
43Platelet activation_Homo sapiens_hsa046111.08623020
44HTLV-I infection_Homo sapiens_hsa051661.03853543
45Hepatitis C_Homo sapiens_hsa051600.99965091
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98298772
47VEGF signaling pathway_Homo sapiens_hsa043700.97774630
48Malaria_Homo sapiens_hsa051440.96678774
49Renal cell carcinoma_Homo sapiens_hsa052110.96255609
50Colorectal cancer_Homo sapiens_hsa052100.95647190
51mTOR signaling pathway_Homo sapiens_hsa041500.95631182
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.95307992
53Inositol phosphate metabolism_Homo sapiens_hsa005620.92554711
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92472074
55Endometrial cancer_Homo sapiens_hsa052130.91027674
56Prostate cancer_Homo sapiens_hsa052150.86193977
57Notch signaling pathway_Homo sapiens_hsa043300.86187044
58Dorso-ventral axis formation_Homo sapiens_hsa043200.84903477
59FoxO signaling pathway_Homo sapiens_hsa040680.82255313
60Systemic lupus erythematosus_Homo sapiens_hsa053220.79767677
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.79659453
62Choline metabolism in cancer_Homo sapiens_hsa052310.79461754
63Prolactin signaling pathway_Homo sapiens_hsa049170.78771322
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77402602
65African trypanosomiasis_Homo sapiens_hsa051430.71387193
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69710388
67Small cell lung cancer_Homo sapiens_hsa052220.68636476
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66009798
69HIF-1 signaling pathway_Homo sapiens_hsa040660.64983810
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64462219
71Insulin resistance_Homo sapiens_hsa049310.63020359
72GnRH signaling pathway_Homo sapiens_hsa049120.62453902
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62416072
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.61178002
75MAPK signaling pathway_Homo sapiens_hsa040100.60678708
76Glioma_Homo sapiens_hsa052140.59285373
77Endocytosis_Homo sapiens_hsa041440.54308680
78Shigellosis_Homo sapiens_hsa051310.54210243
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52216763
80Rheumatoid arthritis_Homo sapiens_hsa053230.52207281
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51774499
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51030571
83ErbB signaling pathway_Homo sapiens_hsa040120.50812776
84Thyroid cancer_Homo sapiens_hsa052160.50607689
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49635807
86Legionellosis_Homo sapiens_hsa051340.49427625
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.49330767
88Pertussis_Homo sapiens_hsa051330.47258426
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46903232
90Phagosome_Homo sapiens_hsa041450.46724877
91MicroRNAs in cancer_Homo sapiens_hsa052060.44484999
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41919810
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.39500633
94Estrogen signaling pathway_Homo sapiens_hsa049150.38772004
95Long-term potentiation_Homo sapiens_hsa047200.37739931
96Type II diabetes mellitus_Homo sapiens_hsa049300.36184360
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.33936159
98Ras signaling pathway_Homo sapiens_hsa040140.33361358
99Rap1 signaling pathway_Homo sapiens_hsa040150.33234856
100Insulin signaling pathway_Homo sapiens_hsa049100.33128564

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