GRASP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.62477427
2negative regulation of erythrocyte differentiation (GO:0045647)4.44784513
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41040669
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38618979
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.25713429
6response to muramyl dipeptide (GO:0032495)4.12761173
7regulation of glutamate receptor signaling pathway (GO:1900449)4.04196904
8vocalization behavior (GO:0071625)3.96387700
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96058963
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.81712197
11regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72410500
12G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.69190876
13synaptic vesicle maturation (GO:0016188)3.64316082
14negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.55317330
15regulation of synapse structural plasticity (GO:0051823)3.55121942
16response to peptidoglycan (GO:0032494)3.46436029
17dendritic spine organization (GO:0097061)3.46168484
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43667310
19regulation of neuronal synaptic plasticity (GO:0048168)3.43603069
20synaptic transmission, glutamatergic (GO:0035249)3.43396068
21protein localization to synapse (GO:0035418)3.35892778
22tolerance induction (GO:0002507)3.33697172
23glutamate secretion (GO:0014047)3.33300360
24positive regulation of neurotransmitter secretion (GO:0001956)3.32772811
25exploration behavior (GO:0035640)3.31513414
26glutamate receptor signaling pathway (GO:0007215)3.27623231
27positive regulation of gamma-delta T cell activation (GO:0046645)3.26744295
28mannose metabolic process (GO:0006013)3.24621985
29regulation of T-helper 2 cell differentiation (GO:0045628)3.19680620
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18885006
31dendritic spine morphogenesis (GO:0060997)3.18444503
32synaptic vesicle exocytosis (GO:0016079)3.14904416
33regulation of synaptic plasticity (GO:0048167)3.10958155
34regulation of dendritic spine morphogenesis (GO:0061001)3.09654560
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07734769
36regulation of synaptic vesicle exocytosis (GO:2000300)3.05247492
37long term synaptic depression (GO:0060292)3.04709355
38positive regulation of Rap GTPase activity (GO:0032854)3.04245338
39germinal center formation (GO:0002467)3.04036062
40negative regulation of interleukin-12 production (GO:0032695)3.02496607
41long-term memory (GO:0007616)2.97061386
42neuron-neuron synaptic transmission (GO:0007270)2.95159932
43positive regulation of dendritic spine morphogenesis (GO:0061003)2.93731282
44regulation of postsynaptic membrane potential (GO:0060078)2.92747158
45neurotransmitter-gated ion channel clustering (GO:0072578)2.92474478
46response to laminar fluid shear stress (GO:0034616)2.92278895
47regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.91746108
48long-term synaptic potentiation (GO:0060291)2.87968250
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.87556702
50regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85729626
51positive thymic T cell selection (GO:0045059)2.85691838
52regulation of p38MAPK cascade (GO:1900744)2.84735992
53regulation of gamma-delta T cell activation (GO:0046643)2.84447713
54synaptic vesicle endocytosis (GO:0048488)2.83523542
55activation of MAPKKK activity (GO:0000185)2.83318398
56regulation of synaptic vesicle transport (GO:1902803)2.80974811
57gamma-aminobutyric acid signaling pathway (GO:0007214)2.80718871
58positive regulation of neurotransmitter transport (GO:0051590)2.80712540
59positive regulation of synapse maturation (GO:0090129)2.79156283
60positive regulation of type 2 immune response (GO:0002830)2.78217793
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77623411
62positive regulation of dendrite morphogenesis (GO:0050775)2.77288748
63glycosphingolipid biosynthetic process (GO:0006688)2.75119442
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75025774
65positive regulation of membrane potential (GO:0045838)2.72182607
66proline transport (GO:0015824)2.72031463
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71874243
68regulation of T-helper 1 cell differentiation (GO:0045625)2.69114206
69detection of calcium ion (GO:0005513)2.68490367
70regulation of ARF protein signal transduction (GO:0032012)2.67903277
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66745659
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66666296
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.65229349
74establishment of endothelial barrier (GO:0061028)2.63951896
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61736781
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61283568
77response to pheromone (GO:0019236)2.58683216
78regulation of dendritic spine development (GO:0060998)2.57200633
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56625148
80macrophage activation involved in immune response (GO:0002281)2.56219460
81regulation of vesicle fusion (GO:0031338)2.55884036
82regulation of synapse maturation (GO:0090128)2.54609801
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54115826
84mature B cell differentiation involved in immune response (GO:0002313)2.52893402
85regulation of gamma-delta T cell differentiation (GO:0045586)2.51454087
86regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.50856187
87negative regulation of cytokine production involved in immune response (GO:0002719)2.50585350
88presynaptic membrane assembly (GO:0097105)2.50573234
89neuronal ion channel clustering (GO:0045161)2.49246561
90positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48433516
91endothelium development (GO:0003158)2.48000404
92neutrophil activation involved in immune response (GO:0002283)2.47863380
93behavioral fear response (GO:0001662)2.47100376
94behavioral defense response (GO:0002209)2.47100376
95presynaptic membrane organization (GO:0097090)2.45908194
96signal complex assembly (GO:0007172)2.45736150
97positive regulation of fibroblast migration (GO:0010763)2.45655154
98negative regulation of blood vessel endothelial cell migration (GO:0043537)2.42063457
99cAMP catabolic process (GO:0006198)2.41587590
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40552297
101neuron projection extension involved in neuron projection guidance (GO:1902284)2.39785036
102axon extension involved in axon guidance (GO:0048846)2.39785036
103regulation of type 2 immune response (GO:0002828)2.38391036
104negative regulation of cell killing (GO:0031342)2.38389439
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38389439
106response to amphetamine (GO:0001975)2.38192355
107cellular extravasation (GO:0045123)2.37765394
108regulation of B cell receptor signaling pathway (GO:0050855)2.37491662
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37141687
110postsynaptic membrane organization (GO:0001941)2.36971739
111immunoglobulin mediated immune response (GO:0016064)2.36152276
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35970980
113positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.35797983
114positive regulation of dendrite development (GO:1900006)2.35398195
115NIK/NF-kappaB signaling (GO:0038061)2.35300523
116negative regulation of granulocyte differentiation (GO:0030853)2.35070664
117neuron recognition (GO:0008038)2.34357553
118chemical homeostasis within a tissue (GO:0048875)2.34170917
119positive regulation of dendritic spine development (GO:0060999)2.33732108
120regulation of inositol phosphate biosynthetic process (GO:0010919)2.33591595
121endothelial cell chemotaxis (GO:0035767)2.32928885
122regulation of T cell tolerance induction (GO:0002664)2.32728972
123cellular response to thyroid hormone stimulus (GO:0097067)2.31828409
124cellular response to epinephrine stimulus (GO:0071872)2.31753793
125cell communication by electrical coupling (GO:0010644)2.31691243
126myeloid dendritic cell differentiation (GO:0043011)2.31307336
127positive T cell selection (GO:0043368)2.30826158
128regulation of germinal center formation (GO:0002634)2.30659932
129learning (GO:0007612)2.30643219
130regulation of tolerance induction (GO:0002643)2.30214630
131axonal fasciculation (GO:0007413)2.28880552
132angiogenesis involved in wound healing (GO:0060055)2.28451062
133adenosine receptor signaling pathway (GO:0001973)2.27947156
134detection of other organism (GO:0098543)2.27616672
135glial cell proliferation (GO:0014009)2.27274994
136negative regulation of interleukin-6 production (GO:0032715)2.27112116
137regulation of vitamin D biosynthetic process (GO:0060556)2.26787875
138thymic T cell selection (GO:0045061)2.25751463
139membrane depolarization (GO:0051899)2.25295899
140defense response to protozoan (GO:0042832)2.24089800
141fear response (GO:0042596)2.23490353
142regulation of ARF GTPase activity (GO:0032312)2.23483398
143positive regulation of cellular amide metabolic process (GO:0034250)2.23336987
144sialylation (GO:0097503)2.23321998
145regulation of Rap GTPase activity (GO:0032317)2.23137203
146positive regulation of cardiac muscle cell differentiation (GO:2000727)2.22998371
147regulation of mast cell degranulation (GO:0043304)2.22803212
148positive regulation of CREB transcription factor activity (GO:0032793)2.22662118
149response to auditory stimulus (GO:0010996)2.21987316
150ephrin receptor signaling pathway (GO:0048013)2.21574576
151central nervous system projection neuron axonogenesis (GO:0021952)2.21514593
152regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.21345090
153regulation of leukocyte degranulation (GO:0043300)2.21123212
154T cell selection (GO:0045058)2.20597981
155regulation of neurotransmitter secretion (GO:0046928)2.19722257
156macrophage activation (GO:0042116)2.19085039
157positive regulation by symbiont of host defense response (GO:0052509)2.18629863
158modulation by symbiont of host defense response (GO:0052031)2.18629863
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18629863
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18629863
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.18629863
162modulation by symbiont of host immune response (GO:0052553)2.18629863
163cAMP biosynthetic process (GO:0006171)2.18050909
164positive regulation of synaptic transmission (GO:0050806)2.18022116
165negative regulation of toll-like receptor signaling pathway (GO:0034122)2.17556007
166negative regulation of production of molecular mediator of immune response (GO:0002701)2.17270629
167regulation of antigen processing and presentation (GO:0002577)2.16835759
168response to fluid shear stress (GO:0034405)2.16358767
169interferon-gamma-mediated signaling pathway (GO:0060333)2.16082861
170detection of bacterium (GO:0016045)2.15925896
171T-helper 1 type immune response (GO:0042088)2.15200345
172neuronal action potential propagation (GO:0019227)2.14374596
173regulation of synaptic transmission (GO:0050804)2.14127765
174chemosensory behavior (GO:0007635)2.13890458
175peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.13161081
176positive regulation of T-helper cell differentiation (GO:0045624)2.12857469
177mature B cell differentiation (GO:0002335)2.11429487
178regulation of myeloid leukocyte mediated immunity (GO:0002886)2.11394347
179negative regulation of innate immune response (GO:0045824)2.10713124
180cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.10626554
181regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.09948837
182positive regulation of antigen processing and presentation (GO:0002579)2.09671574
183JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.09655019
184positive regulation of tolerance induction (GO:0002645)2.09198216
185myeloid dendritic cell activation (GO:0001773)2.09095685
186negative regulation of smooth muscle cell proliferation (GO:0048662)2.08292927
187positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.07816808
188regulation of interleukin-2 biosynthetic process (GO:0045076)2.07751895
189regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.07277953
190positive regulation of mast cell activation involved in immune response (GO:0033008)2.07272766
191positive regulation of mast cell degranulation (GO:0043306)2.07272766
192T cell migration (GO:0072678)2.07167649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71516073
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.26288157
3GBX2_23144817_ChIP-Seq_PC3_Human3.17923542
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97740543
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78241717
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.73673866
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71174896
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.67568649
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65003863
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65003863
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54007366
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51711686
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50372930
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44139584
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39714729
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.35676004
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32167550
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.30989148
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.27577418
20* KDM2B_26808549_Chip-Seq_DND41_Human2.20947211
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18686021
22TCF7_22412390_ChIP-Seq_EML_Mouse2.13658764
23VDR_21846776_ChIP-Seq_THP-1_Human2.09565335
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05559179
25DROSHA_22980978_ChIP-Seq_HELA_Human2.04291494
26LXR_22292898_ChIP-Seq_THP-1_Human2.03783715
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02915820
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02514020
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02175480
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01820686
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01650719
32* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00568125
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.98093288
34VDR_24763502_ChIP-Seq_THP-1_Human1.83366459
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79969941
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76066490
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.75021333
38REST_21632747_ChIP-Seq_MESCs_Mouse1.73553970
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72768657
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.72227552
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71708260
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71284029
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66480351
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66146320
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65924539
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63346451
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63216255
48MYC_22102868_ChIP-Seq_BL_Human1.61676169
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61003317
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59954985
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.57276573
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56813912
53* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55619136
54SCL_19346495_ChIP-Seq_HPC-7_Human1.54914544
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.50410031
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50318146
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49347861
58* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49160715
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48484697
60MAF_26560356_Chip-Seq_TH1_Human1.46585073
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44031123
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43961874
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43504245
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41845903
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41483948
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.41286844
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40445695
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38466469
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.38207322
70SPI1_23127762_ChIP-Seq_K562_Human1.37935649
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36987784
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36531718
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36102087
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.35420263
75* KDM2B_26808549_Chip-Seq_K562_Human1.32839588
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31343067
77VDR_24787735_ChIP-Seq_THP-1_Human1.30753763
78UTX_26944678_Chip-Seq_JUKART_Human1.29430503
79TP53_16413492_ChIP-PET_HCT116_Human1.27599246
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.26884689
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25999307
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.23137997
83* REST_18959480_ChIP-ChIP_MESCs_Mouse1.21203041
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21145677
85SMAD4_21799915_ChIP-Seq_A2780_Human1.21016696
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20429648
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20426326
88* MAF_26560356_Chip-Seq_TH2_Human1.19578223
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17094984
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16785130
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16641221
92* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16528614
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16118814
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15286128
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15286128
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14628559
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14385025
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13617461
99RXR_22108803_ChIP-Seq_LS180_Human1.13351851
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.10989809
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10902914
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.10449087
103TP53_18474530_ChIP-ChIP_U2OS_Human1.10388869
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10282252
105* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10198860
106GATA1_19941826_ChIP-Seq_K562_Human1.10001900
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09617820
108RACK7_27058665_Chip-Seq_MCF-7_Human1.09559682
109AR_19668381_ChIP-Seq_PC3_Human1.09353257
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07467069
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07279542
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.07093509
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.06454104
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.06070545
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05429447
116P300_19829295_ChIP-Seq_ESCs_Human1.05331122
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04654421
118* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04454297
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04160478
120* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03928323
121* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03928323
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03350574
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03235292
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.02672925
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01789224
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01216839
127SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00935266
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99908225
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99359237
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99338732
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99170403
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98302011
133AHR_22903824_ChIP-Seq_MCF-7_Human0.97933285
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.97896788
135CTCF_27219007_Chip-Seq_Bcells_Human0.97328982
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96336443
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.95506282
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95236315
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94025774
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.93995653
141CREB1_26743006_Chip-Seq_LNCaP_Human0.93937395
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93930271
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.93441780
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93220759
145SMC4_20622854_ChIP-Seq_HELA_Human0.92951192
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.92938818
147AR_21572438_ChIP-Seq_LNCaP_Human0.92541518
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92057125
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90383098
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90375205
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90324057
152STAT3_23295773_ChIP-Seq_U87_Human0.90253289
153CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90199133
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.89940398
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.88871820
156RUNX_20019798_ChIP-Seq_JUKART_Human0.88545135
157* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88457273
158GATA2_21666600_ChIP-Seq_HMVEC_Human0.87793394
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.87553287
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87184395
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86530152
162RNF2_27304074_Chip-Seq_NSC_Mouse0.86437900
163SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86360630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43617523
2MP0003436_decreased_susceptibility_to3.37376088
3MP0004510_myositis3.30807904
4MP0003880_abnormal_central_pattern3.25804880
5MP0003635_abnormal_synaptic_transmissio3.18434251
6MP0003724_increased_susceptibility_to3.15004832
7* MP0009745_abnormal_behavioral_response2.76329272
8MP0002822_catalepsy2.71120445
9* MP0002063_abnormal_learning/memory/cond2.68344051
10MP0003787_abnormal_imprinting2.53929060
11MP0005058_abnormal_lysosome_morphology2.48310738
12MP0003172_abnormal_lysosome_physiology2.46090842
13MP0001188_hyperpigmentation2.45023047
14MP0009278_abnormal_bone_marrow2.36357778
15MP0003300_gastrointestinal_ulcer2.21220830
16MP0005000_abnormal_immune_tolerance2.18937267
17MP0001501_abnormal_sleep_pattern2.18335613
18MP0002572_abnormal_emotion/affect_behav2.12270749
19MP0005167_abnormal_blood-brain_barrier2.07250635
20MP0002064_seizures2.03033205
21MP0002419_abnormal_innate_immunity1.97676399
22MP0002933_joint_inflammation1.91084406
23MP0001968_abnormal_touch/_nociception1.87140472
24MP0001533_abnormal_skeleton_physiology1.85078128
25MP0006082_CNS_inflammation1.80287659
26MP0001486_abnormal_startle_reflex1.79872511
27MP0001790_abnormal_immune_system1.79767541
28MP0005387_immune_system_phenotype1.79767541
29MP0004947_skin_inflammation1.74173869
30MP0001800_abnormal_humoral_immune1.73484400
31MP0005025_abnormal_response_to1.71909068
32MP0005623_abnormal_meninges_morphology1.71130665
33MP0002736_abnormal_nociception_after1.67117178
34MP0008004_abnormal_stomach_pH1.64029222
35MP0009840_abnormal_foam_cell1.63038380
36MP0002723_abnormal_immune_serum1.62725307
37MP0004270_analgesia1.61066709
38MP0002452_abnormal_antigen_presenting1.59810799
39MP0002735_abnormal_chemical_nociception1.57112005
40MP0003941_abnormal_skin_development1.57062464
41MP0005310_abnormal_salivary_gland1.54836686
42MP0003045_fibrosis1.53176176
43MP0000685_abnormal_immune_system1.52746511
44MP0009785_altered_susceptibility_to1.51313314
45MP0002420_abnormal_adaptive_immunity1.49499394
46MP0001819_abnormal_immune_cell1.47869748
47MP0003690_abnormal_glial_cell1.44044225
48MP0002272_abnormal_nervous_system1.42587713
49MP0001440_abnormal_grooming_behavior1.41801069
50MP0004858_abnormal_nervous_system1.40819535
51MP0001851_eye_inflammation1.38952971
52MP0003763_abnormal_thymus_physiology1.38807494
53MP0004484_altered_response_of1.38034047
54MP0010155_abnormal_intestine_physiology1.36360543
55MP0008260_abnormal_autophagy1.35528713
56MP0005423_abnormal_somatic_nervous1.35414891
57MP0003828_pulmonary_edema1.32407393
58MP0009764_decreased_sensitivity_to1.31537646
59MP0001879_abnormal_lymphatic_vessel1.30249344
60MP0001545_abnormal_hematopoietic_system1.30102222
61MP0005397_hematopoietic_system_phenotyp1.30102222
62MP0001986_abnormal_taste_sensitivity1.29958042
63MP0010368_abnormal_lymphatic_system1.29827386
64MP0003879_abnormal_hair_cell1.29610807
65MP0005171_absent_coat_pigmentation1.28441780
66MP0002405_respiratory_system_inflammati1.26156219
67MP0000465_gastrointestinal_hemorrhage1.26091777
68MP0000604_amyloidosis1.24912013
69MP0009046_muscle_twitch1.23543594
70MP0000249_abnormal_blood_vessel1.22395286
71MP0000569_abnormal_digit_pigmentation1.22020959
72MP0002332_abnormal_exercise_endurance1.21034061
73MP0002557_abnormal_social/conspecific_i1.20555325
74MP0000678_abnormal_parathyroid_gland1.16910213
75MP0004130_abnormal_muscle_cell1.16849582
76MP0008961_abnormal_basal_metabolism1.15718177
77MP0002877_abnormal_melanocyte_morpholog1.15558762
78MP0005535_abnormal_body_temperature1.15437751
79MP0000343_altered_response_to1.15305266
80MP0001346_abnormal_lacrimal_gland1.13765952
81MP0003122_maternal_imprinting1.13167996
82MP0004811_abnormal_neuron_physiology1.11138311
83MP0003075_altered_response_to1.11051216
84MP0002163_abnormal_gland_morphology1.09491752
85MP0006292_abnormal_olfactory_placode1.09398879
86MP0000751_myopathy1.08204483
87MP0005377_hearing/vestibular/ear_phenot1.07766783
88MP0003878_abnormal_ear_physiology1.07766783
89MP0005646_abnormal_pituitary_gland1.07473088
90MP0001845_abnormal_inflammatory_respons1.07383461
91MP0000716_abnormal_immune_system1.06993017
92MP0003329_amyloid_beta_deposits1.06869165
93MP0005464_abnormal_platelet_physiology1.06708867
94MP0001502_abnormal_circadian_rhythm1.06166922
95MP0005165_increased_susceptibility_to1.04909741
96MP0004085_abnormal_heartbeat1.04438178
97MP0000920_abnormal_myelination1.03519713
98MP0005390_skeleton_phenotype1.03033456
99MP0005645_abnormal_hypothalamus_physiol1.02216909
100MP0002009_preneoplasia1.01758477
101MP0001542_abnormal_bone_strength0.98829422
102MP0002398_abnormal_bone_marrow0.97378500
103MP0005595_abnormal_vascular_smooth0.96454677
104MP0002184_abnormal_innervation0.96415821
105MP0003705_abnormal_hypodermis_morpholog0.95571110
106MP0001348_abnormal_lacrimal_gland0.95535765
107MP0003191_abnormal_cellular_cholesterol0.93255697
108MP0001958_emphysema0.93195426
109MP0006138_congestive_heart_failure0.90470385
110MP0003303_peritoneal_inflammation0.89488803
111MP0002734_abnormal_mechanical_nocicepti0.89284984
112MP0008569_lethality_at_weaning0.89137406
113MP0003448_altered_tumor_morphology0.88908998
114MP0005367_renal/urinary_system_phenotyp0.88634082
115MP0000516_abnormal_urinary_system0.88634082
116MP0008469_abnormal_protein_level0.88358585
117MP0005164_abnormal_response_to0.87949135
118MP0005670_abnormal_white_adipose0.87296716
119MP0004883_abnormal_blood_vessel0.86971389
120MP0002067_abnormal_sensory_capabilities0.85921511
121MP0003119_abnormal_digestive_system0.85136108
122MP0002277_abnormal_respiratory_mucosa0.83023831
123MP0005076_abnormal_cell_differentiation0.82258764
124MP0009780_abnormal_chondrocyte_physiolo0.82047043
125MP0000858_altered_metastatic_potential0.82007756
126MP0005666_abnormal_adipose_tissue0.80605107
127MP0003385_abnormal_body_wall0.80291937
128MP0000778_abnormal_nervous_system0.79825463
129MP0005257_abnormal_intraocular_pressure0.78228714
130MP0004133_heterotaxia0.77385143
131MP0001664_abnormal_digestion0.77198783
132MP0005409_darkened_coat_color0.77161004
133MP0004036_abnormal_muscle_relaxation0.77098726
134MP0004084_abnormal_cardiac_muscle0.76043949
135MP0008874_decreased_physiological_sensi0.76009611
136MP0003633_abnormal_nervous_system0.74896291
137MP0002909_abnormal_adrenal_gland0.74344179
138* MP0001970_abnormal_pain_threshold0.73965747
139MP0003091_abnormal_cell_migration0.72609837
140MP0002733_abnormal_thermal_nociception0.71644004
141MP0010234_abnormal_vibrissa_follicle0.70640772
142MP0004742_abnormal_vestibular_system0.70627294
143MP0002066_abnormal_motor_capabilities/c0.68852651
144MP0004885_abnormal_endolymph0.68802822
145MP0002138_abnormal_hepatobiliary_system0.67322514
146MP0000015_abnormal_ear_pigmentation0.67262782
147MP0002925_abnormal_cardiovascular_devel0.66122096
148MP0003121_genomic_imprinting0.65277627
149MP0000955_abnormal_spinal_cord0.64648591
150MP0002882_abnormal_neuron_morphology0.63203294
151MP0001853_heart_inflammation0.62643079
152MP0001177_atelectasis0.62393101
153MP0000681_abnormal_thyroid_gland0.62208107
154MP0002254_reproductive_system_inflammat0.61093861
155MP0002148_abnormal_hypersensitivity_rea0.60652576
156MP0005166_decreased_susceptibility_to0.60430510
157MP0003279_aneurysm0.60324906
158MP0008995_early_reproductive_senescence0.60202289
159MP0001835_abnormal_antigen_presentation0.59672453
160MP0010352_gastrointestinal_tract_polyps0.59460901
161MP0005187_abnormal_penis_morphology0.57736775
162MP0002152_abnormal_brain_morphology0.56546715
163MP0002249_abnormal_larynx_morphology0.56327651
164MP0002998_abnormal_bone_remodeling0.55538082
165MP0005671_abnormal_response_to0.54845592
166MP0000767_abnormal_smooth_muscle0.54056452

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.90018801
2Febrile seizures (HP:0002373)3.88246409
3Myokymia (HP:0002411)3.83066936
4Focal seizures (HP:0007359)3.65360127
5Epileptic encephalopathy (HP:0200134)3.61749985
6Dysostosis multiplex (HP:0000943)3.32620103
7Atonic seizures (HP:0010819)3.29218664
8Visual hallucinations (HP:0002367)3.20163381
9Eczematoid dermatitis (HP:0000976)3.19134249
10Spontaneous hematomas (HP:0007420)3.00073905
11Abnormality of glycolipid metabolism (HP:0010969)2.91687124
12Abnormality of liposaccharide metabolism (HP:0010968)2.91687124
13Abnormality of glycosphingolipid metabolism (HP:0004343)2.91687124
14Asymmetric septal hypertrophy (HP:0001670)2.91617891
15Amyloidosis (HP:0011034)2.87219012
16Supranuclear gaze palsy (HP:0000605)2.86675952
17Stomatitis (HP:0010280)2.86461954
18Absent eyebrow (HP:0002223)2.84248016
19Systemic lupus erythematosus (HP:0002725)2.77872191
20Abnormality of polysaccharide metabolism (HP:0011012)2.74584867
21Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74584867
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74584867
23Papilledema (HP:0001085)2.73345657
24Amelogenesis imperfecta (HP:0000705)2.73253024
25Elevated erythrocyte sedimentation rate (HP:0003565)2.73042632
26Urinary glycosaminoglycan excretion (HP:0003541)2.70486516
27Mucopolysacchariduria (HP:0008155)2.70486516
28Neurofibrillary tangles (HP:0002185)2.69644016
29Myositis (HP:0100614)2.68546716
30Increased cerebral lipofuscin (HP:0011813)2.63199637
31Abnormality of macrophages (HP:0004311)2.58929545
32Amblyopia (HP:0000646)2.53639567
33Distal lower limb amyotrophy (HP:0008944)2.51747144
34Interstitial pulmonary disease (HP:0006530)2.44827543
35Absence seizures (HP:0002121)2.44379483
36Lower limb amyotrophy (HP:0007210)2.44153902
37Retrobulbar optic neuritis (HP:0100654)2.43745882
38Optic neuritis (HP:0100653)2.43745882
39Orchitis (HP:0100796)2.42479582
40Annular pancreas (HP:0001734)2.42255407
41Abnormality of the lower motor neuron (HP:0002366)2.38707325
42Neuronal loss in central nervous system (HP:0002529)2.36077214
43Colitis (HP:0002583)2.34672315
44Primary atrial arrhythmia (HP:0001692)2.34341264
45Muscle fiber splitting (HP:0003555)2.31484813
46Distal lower limb muscle weakness (HP:0009053)2.31062308
47Recurrent bacterial skin infections (HP:0005406)2.30932228
48Dialeptic seizures (HP:0011146)2.29568220
49Segmental peripheral demyelination/remyelination (HP:0003481)2.27931681
50Recurrent abscess formation (HP:0002722)2.27507765
51Absent speech (HP:0001344)2.26845361
52Slow saccadic eye movements (HP:0000514)2.25081884
53Progressive cerebellar ataxia (HP:0002073)2.23935265
54Unilateral renal agenesis (HP:0000122)2.22652176
55Polycythemia (HP:0001901)2.21008420
56Hyperventilation (HP:0002883)2.20905105
57Atrial fibrillation (HP:0005110)2.19995376
58Supraventricular arrhythmia (HP:0005115)2.18646749
59Mediastinal lymphadenopathy (HP:0100721)2.17281990
60Vasculitis (HP:0002633)2.16923452
61Peripheral hypomyelination (HP:0007182)2.16315066
62Loss of speech (HP:0002371)2.15990789
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.15430050
64Supraventricular tachycardia (HP:0004755)2.15369884
65Keratoconjunctivitis sicca (HP:0001097)2.13703154
66Recurrent gram-negative bacterial infections (HP:0005420)2.12631839
67Increased IgE level (HP:0003212)2.11543444
68Aplasia cutis congenita (HP:0001057)2.11290699
69Increased variability in muscle fiber diameter (HP:0003557)2.10234921
70Axonal loss (HP:0003447)2.10172707
71Hemoptysis (HP:0002105)2.08723962
72Prolonged bleeding time (HP:0003010)2.08437417
73Spondylolisthesis (HP:0003302)2.07433271
74Broad face (HP:0000283)2.06976178
75Gastrointestinal stroma tumor (HP:0100723)2.03778015
76Milia (HP:0001056)2.03295972
77Joint stiffness (HP:0001387)2.03229749
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03194399
79Apathy (HP:0000741)2.02079508
80Restrictive lung disease (HP:0002091)2.00850085
81Mutism (HP:0002300)2.00106107
82Protrusio acetabuli (HP:0003179)1.99500061
83Pulmonary infiltrates (HP:0002113)1.98828614
84Generalized tonic-clonic seizures (HP:0002069)1.98114210
85Pointed chin (HP:0000307)1.97656424
86Aortic aneurysm (HP:0004942)1.97071186
87Genetic anticipation (HP:0003743)1.95331315
88Emphysema (HP:0002097)1.93612085
89Abnormality of skeletal muscle fiber size (HP:0012084)1.92399802
90Keratoconjunctivitis (HP:0001096)1.90851203
91Nuclear cataract (HP:0100018)1.90583301
92Impaired smooth pursuit (HP:0007772)1.89714561
93Thin bony cortex (HP:0002753)1.89242133
94Diminished motivation (HP:0000745)1.88868279
95Large eyes (HP:0001090)1.87622528
96Impaired vibration sensation in the lower limbs (HP:0002166)1.86291807
97Cellulitis (HP:0100658)1.86234100
98Broad-based gait (HP:0002136)1.86136189
99Postural instability (HP:0002172)1.84024447
100Cerebral inclusion bodies (HP:0100314)1.83614396
101Deeply set eye (HP:0000490)1.83197646
102Abnormality of the parietal bone (HP:0002696)1.83022536
103Epistaxis (HP:0000421)1.81864351
104Abnormality of the fingertips (HP:0001211)1.80834893
105Gastrointestinal infarctions (HP:0005244)1.80762076
106Syncope (HP:0001279)1.80347423
107Absent eyelashes (HP:0000561)1.80071461
108Stereotypic behavior (HP:0000733)1.79847048
109Hyporeflexia of lower limbs (HP:0002600)1.79722341
110J-shaped sella turcica (HP:0002680)1.79410604
111Increased connective tissue (HP:0009025)1.79391945
112Mildly elevated creatine phosphokinase (HP:0008180)1.79317206
113Aneurysm (HP:0002617)1.77601595
114Rapidly progressive (HP:0003678)1.77046632
115Ankyloglossia (HP:0010296)1.76799184
116Easy fatigability (HP:0003388)1.76705620
117Obstructive lung disease (HP:0006536)1.76085081
118Chronic obstructive pulmonary disease (HP:0006510)1.76085081
119Genu recurvatum (HP:0002816)1.75431375
120Purpura (HP:0000979)1.75294017
121Onion bulb formation (HP:0003383)1.74998465
122Complement deficiency (HP:0004431)1.74815244
123Ocular albinism (HP:0001107)1.74543116
124Inflammation of the large intestine (HP:0002037)1.73350244
125Follicular hyperkeratosis (HP:0007502)1.73199636
126Difficulty running (HP:0009046)1.72929864
127Difficulty climbing stairs (HP:0003551)1.71693914
128Depression (HP:0000716)1.71536269
129Recurrent fungal infections (HP:0002841)1.71158678
130Gastrointestinal inflammation (HP:0004386)1.70850997
131Diplopia (HP:0000651)1.70809257
132Abnormality of binocular vision (HP:0011514)1.70809257
133Abnormality of the periventricular white matter (HP:0002518)1.70752316
134Cerebral aneurysm (HP:0004944)1.70667578
135Porencephaly (HP:0002132)1.70046028
136Chest pain (HP:0100749)1.69586369
137Palpebral edema (HP:0100540)1.69156460
138Decreased circulating renin level (HP:0003351)1.68095375
139Hematochezia (HP:0002573)1.67542018
140Spinal canal stenosis (HP:0003416)1.66166598
141Ventricular fibrillation (HP:0001663)1.65563733
142Hypoventilation (HP:0002791)1.63784987
143Poor eye contact (HP:0000817)1.63263801
144Bradykinesia (HP:0002067)1.62994592
145Arterial tortuosity (HP:0005116)1.60935206
146Double outlet right ventricle (HP:0001719)1.60744242
147Congenital malformation of the right heart (HP:0011723)1.60744242
148Hemiplegia (HP:0002301)1.60623106
149Midline defect of the nose (HP:0004122)1.59555747
150Polygenic inheritance (HP:0010982)1.58679173
151Obsessive-compulsive behavior (HP:0000722)1.57450357
152Skull defect (HP:0001362)1.57401680
153Intestinal atresia (HP:0011100)1.54130854
154Onycholysis (HP:0001806)1.53565544
155Gaze-evoked nystagmus (HP:0000640)1.52774573
156Thickened helices (HP:0000391)1.52350055
157Supernumerary ribs (HP:0005815)1.52234354
158Abnormal EKG (HP:0003115)1.51825121
159Periorbital edema (HP:0100539)1.51598375
160Hyperactive renin-angiotensin system (HP:0000841)1.51072060
161Multifactorial inheritance (HP:0001426)1.50525243
162Resting tremor (HP:0002322)1.49806840
163Vertebral arch anomaly (HP:0008438)1.49495210
164Obstructive sleep apnea (HP:0002870)1.48658780
165Cutaneous finger syndactyly (HP:0010554)1.48607458
166Tented upper lip vermilion (HP:0010804)1.48593954
167Exotropia (HP:0000577)1.47880617
168Deep palmar crease (HP:0006191)1.47741622
169Spinal muscular atrophy (HP:0007269)1.47411084
170Vascular tortuosity (HP:0004948)1.46862157
171Action tremor (HP:0002345)1.46670451
172Abnormal atrioventricular conduction (HP:0005150)1.44486606
173Arterial thrombosis (HP:0004420)1.44420710
174Incomplete penetrance (HP:0003829)1.43431162
175Vertigo (HP:0002321)1.43110546
176Excessive salivation (HP:0003781)1.42719775
177Drooling (HP:0002307)1.42719775
178Urethral obstruction (HP:0000796)1.42606897
179Morphological abnormality of the middle ear (HP:0008609)1.42372230
180Atrophic scars (HP:0001075)1.42275946
181Heart block (HP:0012722)1.41909896
182Abnormality of the nasal septum (HP:0000419)1.41473718
183Dysmetria (HP:0001310)1.41293558
184Oligodontia (HP:0000677)1.41100016
185Heterochromia iridis (HP:0001100)1.40663661
186Sudden death (HP:0001699)1.40188923
187Abnormality of the antihelix (HP:0009738)1.39706696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.24262777
2TIE13.89155515
3NTRK33.82449506
4RIPK43.48440919
5MAP3K133.40954658
6SIK32.61385169
7BMPR22.59144196
8MAP4K12.36969239
9MAP3K92.32333753
10SIK22.31766166
11PRPF4B2.28651628
12TRIB31.69710821
13PTK2B1.68919453
14FES1.67704091
15ZAP701.65745166
16MAP2K71.65686728
17DAPK21.65004681
18BLK1.59632850
19PLK21.59227073
20NTRK21.56160159
21TYK21.56151931
22DMPK1.54057840
23DAPK11.52286102
24TYRO31.48825064
25CDK121.46073334
26MAP2K31.41272456
27IRAK31.40042117
28PRKD31.40019801
29TGFBR21.35932333
30KSR11.32551019
31MAP3K111.29555526
32MAP3K141.27965005
33IRAK21.27343218
34TTN1.27025742
35FGR1.26340791
36MARK21.24137696
37FER1.21407690
38MAP3K41.20176981
39CSK1.19056645
40CAMK11.15834170
41MINK11.15810281
42SIK11.13326082
43ITK1.13022385
44ERN11.12216809
45IRAK41.12112625
46CASK1.09757266
47BTK1.08688151
48MAP3K121.08090173
49MAP3K31.02481435
50KSR21.01307772
51HIPK21.00382621
52CAMKK10.99854260
53CDK50.97300919
54UHMK10.97048319
55RIPK10.94418947
56EPHA20.94140471
57IKBKB0.93882250
58ALK0.92959437
59MAP3K70.92154487
60GRK50.90502518
61TEC0.87306557
62SYK0.86836804
63CHUK0.85812466
64IRAK10.85306026
65FGFR20.85175407
66PAK60.84220962
67ARAF0.83141078
68EPHB10.78055254
69CAMK40.77209379
70AKT30.76937938
71KIT0.76867519
72MAP2K40.76780667
73PDPK10.75270841
74MAPK40.73601194
75STK110.73090627
76TAOK10.72731672
77STK380.72455982
78ICK0.72331648
79FGFR30.71812230
80SGK10.71682684
81RPS6KC10.70525654
82RPS6KL10.70525654
83TAOK20.70486091
84CDK80.70200786
85LCK0.69535780
86MAP3K10.69110093
87RPS6KA20.68678640
88TNK20.68586976
89MAPK150.67121805
90RET0.66593990
91PRKCH0.64669983
92JAK20.64553884
93GRK70.63926471
94PIK3CG0.63040875
95CDK190.61442212
96GRK60.61138706
97RAF10.61107220
98JAK10.60459622
99PDGFRA0.58895363
100CAMK2A0.58449240
101RPS6KA60.58057930
102BMX0.56632012
103SGK4940.55598507
104SGK2230.55598507
105LYN0.53939465
106PRKD20.50669505
107DYRK1B0.50043971
108CDK30.49019094
109CAMKK20.48752793
110JAK30.48390415
111NTRK10.48110695
112MARK30.47939002
113PRKCG0.46568065
114MAPK70.46432406
115DDR20.45146228
116PDGFRB0.44364505
117TNIK0.43320858
118PRKCE0.43246906
119MATK0.42622696
120EPHA30.42463800
121LATS20.41807448
122MUSK0.40108610
123HCK0.37600030
124KDR0.37333010
125FGFR40.36557148
126IKBKE0.36547108
127DYRK1A0.35773616
128PDK10.35512481
129MAP3K20.35354531
130MAPK120.32767898
131SGK30.31675438
132MAPK130.31460509
133STK240.31399663
134CDC42BPA0.31278239
135MAP2K10.30669320
136MAPK100.30441794
137MOS0.30291953
138MAP3K60.29424392
139TXK0.27902840
140PRKAA20.27258436
141TBK10.26354373
142SGK20.26262698

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.46941850
2Other glycan degradation_Homo sapiens_hsa005112.19195686
3Olfactory transduction_Homo sapiens_hsa047402.18328119
4Circadian entrainment_Homo sapiens_hsa047132.10439142
5Long-term potentiation_Homo sapiens_hsa047202.04855328
6Morphine addiction_Homo sapiens_hsa050321.99008331
7Amphetamine addiction_Homo sapiens_hsa050311.93977639
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92822184
9Glutamatergic synapse_Homo sapiens_hsa047241.85235538
10Asthma_Homo sapiens_hsa053101.69508824
11Allograft rejection_Homo sapiens_hsa053301.67966685
12Salivary secretion_Homo sapiens_hsa049701.62909166
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.62234210
14Staphylococcus aureus infection_Homo sapiens_hsa051501.62052565
15Graft-versus-host disease_Homo sapiens_hsa053321.59927595
16Synaptic vesicle cycle_Homo sapiens_hsa047211.54852932
17Cholinergic synapse_Homo sapiens_hsa047251.54708770
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54661344
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.54389562
20Oxytocin signaling pathway_Homo sapiens_hsa049211.54148993
21GABAergic synapse_Homo sapiens_hsa047271.53907530
22Taste transduction_Homo sapiens_hsa047421.53442096
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53420662
24Calcium signaling pathway_Homo sapiens_hsa040201.50215988
25Pertussis_Homo sapiens_hsa051331.48562381
26Insulin secretion_Homo sapiens_hsa049111.42608651
27Renin secretion_Homo sapiens_hsa049241.42311135
28Rheumatoid arthritis_Homo sapiens_hsa053231.42040764
29Dopaminergic synapse_Homo sapiens_hsa047281.41793463
30Autoimmune thyroid disease_Homo sapiens_hsa053201.41097009
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40178906
32Malaria_Homo sapiens_hsa051441.39708588
33Gastric acid secretion_Homo sapiens_hsa049711.34438390
34GnRH signaling pathway_Homo sapiens_hsa049121.32606831
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29240667
36cAMP signaling pathway_Homo sapiens_hsa040241.26917984
37Cocaine addiction_Homo sapiens_hsa050301.24901029
38Long-term depression_Homo sapiens_hsa047301.23526612
39Glioma_Homo sapiens_hsa052141.23116567
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23108187
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22968114
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21018240
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20614325
44Serotonergic synapse_Homo sapiens_hsa047261.20469197
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15440766
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15065724
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09776450
48Influenza A_Homo sapiens_hsa051641.09378629
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07424638
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06763981
51Prion diseases_Homo sapiens_hsa050201.06318295
52ErbB signaling pathway_Homo sapiens_hsa040121.06078958
53VEGF signaling pathway_Homo sapiens_hsa043701.06041068
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05012473
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04527659
56Viral myocarditis_Homo sapiens_hsa054161.03581532
57Axon guidance_Homo sapiens_hsa043601.02726607
58Estrogen signaling pathway_Homo sapiens_hsa049151.01430086
59Dilated cardiomyopathy_Homo sapiens_hsa054140.99006782
60MAPK signaling pathway_Homo sapiens_hsa040100.97242417
61Amoebiasis_Homo sapiens_hsa051460.96865989
62Melanogenesis_Homo sapiens_hsa049160.96023625
63Rap1 signaling pathway_Homo sapiens_hsa040150.95456587
64Osteoclast differentiation_Homo sapiens_hsa043800.93587684
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93338147
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.91137675
67Lysosome_Homo sapiens_hsa041420.90849228
68Gap junction_Homo sapiens_hsa045400.90127917
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89731893
70B cell receptor signaling pathway_Homo sapiens_hsa046620.89657978
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89595216
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.88006968
73Adherens junction_Homo sapiens_hsa045200.87774460
74Hematopoietic cell lineage_Homo sapiens_hsa046400.87042970
75TNF signaling pathway_Homo sapiens_hsa046680.86283929
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.86128169
77Type II diabetes mellitus_Homo sapiens_hsa049300.86075570
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85917574
79Renal cell carcinoma_Homo sapiens_hsa052110.84974212
80Chemokine signaling pathway_Homo sapiens_hsa040620.84928182
81T cell receptor signaling pathway_Homo sapiens_hsa046600.84603471
82Salmonella infection_Homo sapiens_hsa051320.84281925
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84224223
84Ras signaling pathway_Homo sapiens_hsa040140.82964285
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82204450
86African trypanosomiasis_Homo sapiens_hsa051430.81119257
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.80852953
88Choline metabolism in cancer_Homo sapiens_hsa052310.80700771
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.80140095
90Non-small cell lung cancer_Homo sapiens_hsa052230.78326112
91Wnt signaling pathway_Homo sapiens_hsa043100.78071724
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.77275377
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76965651
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76064039
95Legionellosis_Homo sapiens_hsa051340.73528410
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73487547
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71834359
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71749144
99Acute myeloid leukemia_Homo sapiens_hsa052210.71297945
100Chronic myeloid leukemia_Homo sapiens_hsa052200.70370195
101Measles_Homo sapiens_hsa051620.70356736
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70283644
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68154573
104Colorectal cancer_Homo sapiens_hsa052100.67309217
105FoxO signaling pathway_Homo sapiens_hsa040680.67013542
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66647385
107Prolactin signaling pathway_Homo sapiens_hsa049170.66630559
108Pancreatic secretion_Homo sapiens_hsa049720.66616661
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66246708
110Dorso-ventral axis formation_Homo sapiens_hsa043200.65866146
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65000579
112Platelet activation_Homo sapiens_hsa046110.64995669
113Herpes simplex infection_Homo sapiens_hsa051680.64992556
114Insulin resistance_Homo sapiens_hsa049310.64821855
115Inositol phosphate metabolism_Homo sapiens_hsa005620.63963338
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.63721675
117Type I diabetes mellitus_Homo sapiens_hsa049400.63241611
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62434837
119Focal adhesion_Homo sapiens_hsa045100.62400282
120Toxoplasmosis_Homo sapiens_hsa051450.62381088
121Endometrial cancer_Homo sapiens_hsa052130.62212948
122Leishmaniasis_Homo sapiens_hsa051400.62183381
123HIF-1 signaling pathway_Homo sapiens_hsa040660.61922477
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60976877
125Phagosome_Homo sapiens_hsa041450.60294899
126Hepatitis C_Homo sapiens_hsa051600.59943406
127Pancreatic cancer_Homo sapiens_hsa052120.59765831
128Hepatitis B_Homo sapiens_hsa051610.58164206
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58135648
130mTOR signaling pathway_Homo sapiens_hsa041500.57687850
131Shigellosis_Homo sapiens_hsa051310.57649336
132Notch signaling pathway_Homo sapiens_hsa043300.57456753
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55987489
134Circadian rhythm_Homo sapiens_hsa047100.55106699
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.55013158
136Tuberculosis_Homo sapiens_hsa051520.54459219

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