GRB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.02464500
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.79681148
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.57634068
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.40673023
5vascular endothelial growth factor signaling pathway (GO:0038084)4.35840802
6bone trabecula formation (GO:0060346)4.20062399
7hippo signaling (GO:0035329)4.16768768
8pre-miRNA processing (GO:0031054)3.81032864
9polarized epithelial cell differentiation (GO:0030859)3.78433327
10chondrocyte proliferation (GO:0035988)3.74319579
11cardiac myofibril assembly (GO:0055003)3.72393775
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.62924802
13axon extension involved in axon guidance (GO:0048846)3.62924802
14lateral sprouting from an epithelium (GO:0060601)3.62754069
15mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.60514502
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.55735045
17endocardial cushion development (GO:0003197)3.53554385
18outer ear morphogenesis (GO:0042473)3.52935988
19regulation of heart morphogenesis (GO:2000826)3.51543167
20body morphogenesis (GO:0010171)3.46752051
21sequestering of extracellular ligand from receptor (GO:0035581)3.46222480
22retina vasculature morphogenesis in camera-type eye (GO:0061299)3.45917685
23negative regulation of DNA repair (GO:0045738)3.45362969
24regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.44186265
25L-serine metabolic process (GO:0006563)3.44185060
26iron ion import (GO:0097286)3.42910854
27cell proliferation involved in metanephros development (GO:0072203)3.40402585
28glucocorticoid receptor signaling pathway (GO:0042921)3.38848040
29notochord development (GO:0030903)3.35398189
30Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.33778722
31regulation of establishment of planar polarity (GO:0090175)3.28839623
32mesenchymal cell proliferation (GO:0010463)3.25159805
33regulation of endothelial cell chemotaxis (GO:2001026)3.25022588
34mesenchyme morphogenesis (GO:0072132)3.23537639
35collagen fibril organization (GO:0030199)3.22549890
36negative regulation of chondrocyte differentiation (GO:0032331)3.17296500
37coronary vasculature morphogenesis (GO:0060977)3.14596459
38mesenchyme development (GO:0060485)3.12655363
39endothelial cell chemotaxis (GO:0035767)3.11787072
40embryonic skeletal joint morphogenesis (GO:0060272)3.10682603
41endocardial cushion morphogenesis (GO:0003203)3.09019229
42vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.08921298
43camera-type eye morphogenesis (GO:0048593)3.08812721
44atrial septum morphogenesis (GO:0060413)3.08714711
45cell migration involved in sprouting angiogenesis (GO:0002042)3.08346250
46proximal/distal pattern formation (GO:0009954)3.07636974
47gastrulation with mouth forming second (GO:0001702)3.07533502
48embryonic foregut morphogenesis (GO:0048617)3.07157224
49craniofacial suture morphogenesis (GO:0097094)3.06977862
50hindlimb morphogenesis (GO:0035137)3.06702561
51exocrine pancreas development (GO:0031017)3.05993749
52heart morphogenesis (GO:0003007)3.05653638
53midgut development (GO:0007494)3.05598283
54cell migration involved in heart development (GO:0060973)3.05079925
55convergent extension (GO:0060026)3.02142841
56embryonic hindlimb morphogenesis (GO:0035116)2.99389757
57lymphangiogenesis (GO:0001946)2.98886190
58dorsal/ventral axis specification (GO:0009950)2.98638398
59cerebellar Purkinje cell layer development (GO:0021680)2.96736015
60DNA unwinding involved in DNA replication (GO:0006268)2.96423000
61chondrocyte development (GO:0002063)2.95863912
62cochlea morphogenesis (GO:0090103)2.94887806
63mitotic sister chromatid cohesion (GO:0007064)2.94027096
64non-canonical Wnt signaling pathway (GO:0035567)2.94006549
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.92195119
66regulation of transforming growth factor beta2 production (GO:0032909)2.90674559
67cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.89585860
68embryonic cranial skeleton morphogenesis (GO:0048701)2.89143928
69negative regulation of embryonic development (GO:0045992)2.88505739
70regulation of axon extension involved in axon guidance (GO:0048841)2.85976002
71establishment of apical/basal cell polarity (GO:0035089)2.84040586
72positive regulation of hormone biosynthetic process (GO:0046886)2.80790997
73positive regulation of epithelial to mesenchymal transition (GO:0010718)2.80141011
74plasma membrane repair (GO:0001778)2.79937307
75positive regulation of mesenchymal cell proliferation (GO:0002053)2.77452945
76regulation of cardioblast differentiation (GO:0051890)2.77127492
77positive regulation of catenin import into nucleus (GO:0035413)2.76329780
78positive regulation of SMAD protein import into nucleus (GO:0060391)2.75869569
79cerebellar granule cell differentiation (GO:0021707)2.75247528
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.74175226
81import into cell (GO:0098657)2.73878616
82head development (GO:0060322)2.72993322
83negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.72498885
84organ induction (GO:0001759)2.72450518
85protein heterotrimerization (GO:0070208)2.72291683
86establishment of tissue polarity (GO:0007164)2.71205665
87establishment of planar polarity (GO:0001736)2.71205665
88nuclear pore complex assembly (GO:0051292)2.70329225
89biotin metabolic process (GO:0006768)2.70157044
90negative regulation of catenin import into nucleus (GO:0035414)2.69671245
91regulation of SMAD protein import into nucleus (GO:0060390)2.68065738
92regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.67989760
93metanephric mesenchyme development (GO:0072075)2.67678958
94endothelium development (GO:0003158)2.67168766
95regulation of stem cell maintenance (GO:2000036)2.66849397
96kidney mesenchyme development (GO:0072074)2.66742085
97negative regulation of cartilage development (GO:0061037)2.66459268
98nuclear pore organization (GO:0006999)2.65297327
99artery development (GO:0060840)2.65276679
100organ formation (GO:0048645)2.64295726
101positive regulation of p38MAPK cascade (GO:1900745)2.63464477
102trabecula formation (GO:0060343)2.63408141
103outflow tract septum morphogenesis (GO:0003148)2.63357066
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61961540
105axonal fasciculation (GO:0007413)2.61954555
106ventricular cardiac muscle cell development (GO:0055015)2.61743929
107regulation of mesenchymal cell proliferation (GO:0010464)2.61079679
108myofibril assembly (GO:0030239)2.60846249
109lung-associated mesenchyme development (GO:0060484)2.59888656
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.59868929
111cell proliferation involved in kidney development (GO:0072111)2.59365795
112apical protein localization (GO:0045176)2.58808940
113regulation of non-canonical Wnt signaling pathway (GO:2000050)2.58359493
114corticosteroid receptor signaling pathway (GO:0031958)2.57947769
115regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.57343123
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.56248701
117semaphorin-plexin signaling pathway (GO:0071526)2.55706005
118regulation of cardioblast proliferation (GO:0003264)2.55674380
119regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55674380
120embryonic forelimb morphogenesis (GO:0035115)2.55544494
121endothelial cell morphogenesis (GO:0001886)2.55383757
122regulation of translational fidelity (GO:0006450)2.54445482
123regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54260186
124epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.54220366
125anatomical structure regression (GO:0060033)2.54163126
126regulation of sister chromatid cohesion (GO:0007063)2.53933795
127glomerular filtration (GO:0003094)2.53000542
128regulation of axon guidance (GO:1902667)2.52128244
129myelination in peripheral nervous system (GO:0022011)2.52115614
130peripheral nervous system axon ensheathment (GO:0032292)2.52115614
131protein localization to microtubule (GO:0035372)2.49456422
132protein complex localization (GO:0031503)2.48059981
133regulation of NFAT protein import into nucleus (GO:0051532)2.44879483
134cellular protein complex localization (GO:0034629)2.39979682
135prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.39009555
136axon extension (GO:0048675)2.36078898
137adherens junction assembly (GO:0034333)2.33847280
138establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.33166639
139neural tube development (GO:0021915)2.31546102
140positive regulation of histone deacetylation (GO:0031065)2.30756171
141chemical homeostasis within a tissue (GO:0048875)2.30221599
142anterior/posterior axis specification, embryo (GO:0008595)2.28788765
143myoblast fusion (GO:0007520)2.27703943
144positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.26528871
145positive regulation of protein kinase C signaling (GO:0090037)2.26459786
146positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26455170
147neuron recognition (GO:0008038)2.26358165
148protein localization to synapse (GO:0035418)2.24998722
149branching involved in salivary gland morphogenesis (GO:0060445)2.24491974
150regulation of p38MAPK cascade (GO:1900744)2.24406286
151blood vessel endothelial cell migration (GO:0043534)2.23830117
152respiratory system process (GO:0003016)2.20646531
153regulation of catenin import into nucleus (GO:0035412)2.20299440
154asymmetric protein localization (GO:0008105)2.17493222
155negative regulation of vascular permeability (GO:0043116)2.16444416
156morphogenesis of an epithelial sheet (GO:0002011)2.16400861
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.14269156
158lens morphogenesis in camera-type eye (GO:0002089)2.13054561
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.12184258
160basement membrane organization (GO:0071711)2.11323307
161serine family amino acid biosynthetic process (GO:0009070)2.10748551
162dopaminergic neuron differentiation (GO:0071542)2.10303697
163ectodermal placode formation (GO:0060788)2.08219661
164cell surface receptor signaling pathway involved in heart development (GO:0061311)2.06885485
165regulation of mitotic spindle organization (GO:0060236)2.06555429
166cell migration involved in gastrulation (GO:0042074)2.06004830
167synaptic vesicle docking involved in exocytosis (GO:0016081)2.05066464
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.04646323
169dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.04626850
170peptidyl-lysine dimethylation (GO:0018027)2.04082830
171positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.02947226
172negative regulation of potassium ion transmembrane transport (GO:1901380)2.02889675
173positive regulation of vascular permeability (GO:0043117)2.02262017
174surfactant homeostasis (GO:0043129)2.02016117
175syncytium formation by plasma membrane fusion (GO:0000768)2.01876458
176positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.98949667
177focal adhesion assembly (GO:0048041)1.96885817
178cell-substrate adherens junction assembly (GO:0007045)1.96885817
179neuron projection extension (GO:1990138)1.96652632
180heart trabecula formation (GO:0060347)1.96549527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.18651417
2E2F7_22180533_ChIP-Seq_HELA_Human5.17889277
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.69271287
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.91359661
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.18142928
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.09764221
7* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.83676633
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.83573805
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.72841439
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.66927065
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65329459
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.52738728
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45115448
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37961186
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.28820095
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.19782597
17* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15428693
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12098945
19ZNF263_19887448_ChIP-Seq_K562_Human2.09895462
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09752673
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09752673
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09752673
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08252420
24ISL1_27105846_Chip-Seq_CPCs_Mouse2.05504720
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05311438
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.03061052
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01726148
28TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.90412142
29CLOCK_20551151_ChIP-Seq_293T_Human1.88484445
30* AR_21909140_ChIP-Seq_LNCAP_Human1.84648839
31* EP300_21415370_ChIP-Seq_HL-1_Mouse1.80499210
32FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.76069454
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72141587
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69893395
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.69734414
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67606865
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66359489
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65532929
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65176620
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61105506
41* KDM2B_26808549_Chip-Seq_K562_Human1.60035431
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57011611
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.56977026
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56170832
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55508921
46BRD4_25478319_ChIP-Seq_HGPS_Human1.55235678
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53807575
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51180508
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48722124
50AR_21572438_ChIP-Seq_LNCaP_Human1.48470727
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.47431544
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.46693972
53* TP53_20018659_ChIP-ChIP_R1E_Mouse1.46598054
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45081587
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.43844768
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.43660684
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42529673
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.42461149
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41591829
60* ESR2_21235772_ChIP-Seq_MCF-7_Human1.41547892
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40216922
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.39451427
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.38671652
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.36487404
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33825500
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33584603
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33059403
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30905021
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30247296
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29735038
71* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29559340
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28886557
73POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28479100
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27772207
75* EZH2_27304074_Chip-Seq_ESCs_Mouse1.27189196
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25308412
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20284882
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19824825
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19385403
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18394835
81* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18168189
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18013174
83MYC_22102868_ChIP-Seq_BL_Human1.15788616
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15513658
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15404404
86CHD1_26751641_Chip-Seq_LNCaP_Human1.14515075
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.14321247
88ZNF274_21170338_ChIP-Seq_K562_Hela1.14313117
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.13584109
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11985052
91* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10879059
92* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08084631
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06716863
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.06323951
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05162187
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05116003
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04034082
98CREB1_26743006_Chip-Seq_LNCaP_Human1.03908352
99* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03705062
100* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03705062
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03346192
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.02965686
103TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02025955
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01930169
105* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01924578
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01823461
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01594248
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00789255
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00718761
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00497215
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00397183
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.00281062
113* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99781444
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99627865
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98847037
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98813297
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98440069
118GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98342437
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97820782
120EZH2_22144423_ChIP-Seq_EOC_Human0.96281916
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96254636
122* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95009757
123* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94982154
124* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94982154
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94864851
126* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93389411
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93342613
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92984545
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.92596249
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.92136517
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92033115
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91747012
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91397946
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91125588
135* SOX9_26525672_Chip-Seq_HEART_Mouse0.89174272
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88823142
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.88377674
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.88060466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.44733896
2MP0004858_abnormal_nervous_system3.55112758
3MP0010030_abnormal_orbit_morphology3.41709828
4MP0008438_abnormal_cutaneous_collagen3.24970074
5MP0009053_abnormal_anal_canal3.05501614
6MP0005503_abnormal_tendon_morphology2.94179694
7MP0003385_abnormal_body_wall2.82843689
8MP0000537_abnormal_urethra_morphology2.75755962
9MP0003705_abnormal_hypodermis_morpholog2.63021339
10MP0004272_abnormal_basement_membrane2.56967882
11* MP0003121_genomic_imprinting2.35463328
12MP0009379_abnormal_foot_pigmentation2.34168789
13MP0009250_abnormal_appendicular_skeleto2.26555452
14* MP0003123_paternal_imprinting2.14605170
15MP0003942_abnormal_urinary_system2.11057201
16MP0005623_abnormal_meninges_morphology2.05688657
17MP0003937_abnormal_limbs/digits/tail_de2.03986547
18MP0006054_spinal_hemorrhage2.03949150
19MP0003567_abnormal_fetal_cardiomyocyte2.02780976
20MP0002938_white_spotting1.97584679
21MP0005275_abnormal_skin_tensile1.91792901
22MP0000428_abnormal_craniofacial_morphol1.86039087
23MP0003941_abnormal_skin_development1.84255873
24MP0000049_abnormal_middle_ear1.84201718
25MP0002932_abnormal_joint_morphology1.78651414
26MP0000534_abnormal_ureter_morphology1.74660420
27MP0004859_abnormal_synaptic_plasticity1.74603064
28MP0000733_abnormal_muscle_development1.71888163
29MP0003935_abnormal_craniofacial_develop1.71665045
30MP0003115_abnormal_respiratory_system1.69267450
31MP0003279_aneurysm1.65170307
32MP0004084_abnormal_cardiac_muscle1.62548244
33MP0002249_abnormal_larynx_morphology1.60011993
34MP0003755_abnormal_palate_morphology1.59453198
35MP0005187_abnormal_penis_morphology1.55335401
36MP0000747_muscle_weakness1.55079189
37MP0005076_abnormal_cell_differentiation1.54384451
38MP0003119_abnormal_digestive_system1.52902879
39MP0003890_abnormal_embryonic-extraembry1.52128558
40MP0010368_abnormal_lymphatic_system1.51240388
41MP0000778_abnormal_nervous_system1.49218576
42MP0003283_abnormal_digestive_organ1.48850095
43MP0005508_abnormal_skeleton_morphology1.47357954
44* MP0004197_abnormal_fetal_growth/weight/1.46774094
45MP0009384_cardiac_valve_regurgitation1.44626509
46* MP0004233_abnormal_muscle_weight1.44163245
47MP0001293_anophthalmia1.43572503
48MP0005409_darkened_coat_color1.36171010
49MP0002116_abnormal_craniofacial_bone1.34815187
50MP0002822_catalepsy1.34739935
51MP0001299_abnormal_eye_distance/1.31869031
52MP0002084_abnormal_developmental_patter1.31732364
53MP0004036_abnormal_muscle_relaxation1.31455249
54MP0002085_abnormal_embryonic_tissue1.30971402
55MP0002233_abnormal_nose_morphology1.30703590
56MP0000566_synostosis1.30573025
57* MP0002282_abnormal_trachea_morphology1.30507041
58MP0000749_muscle_degeneration1.28996065
59MP0002109_abnormal_limb_morphology1.26152819
60MP0000432_abnormal_head_morphology1.25912473
61MP0005248_abnormal_Harderian_gland1.23775470
62MP0002111_abnormal_tail_morphology1.19409346
63MP0009703_decreased_birth_body1.18977586
64MP0005367_renal/urinary_system_phenotyp1.16817694
65MP0000516_abnormal_urinary_system1.16817694
66MP0009672_abnormal_birth_weight1.16693099
67MP0002108_abnormal_muscle_morphology1.15429221
68MP0002114_abnormal_axial_skeleton1.15353513
69MP0010352_gastrointestinal_tract_polyps1.14967621
70MP0010630_abnormal_cardiac_muscle1.14363355
71MP0000579_abnormal_nail_morphology1.13162339
72MP0002925_abnormal_cardiovascular_devel1.12925177
73* MP0005380_embryogenesis_phenotype1.11839856
74* MP0001672_abnormal_embryogenesis/_devel1.11839856
75* MP0002088_abnormal_embryonic_growth/wei1.11591544
76MP0000767_abnormal_smooth_muscle1.10330933
77MP0006138_congestive_heart_failure1.10219036
78MP0001697_abnormal_embryo_size1.09832819
79MP0005666_abnormal_adipose_tissue1.09785576
80* MP0003984_embryonic_growth_retardation1.09432498
81MP0000163_abnormal_cartilage_morphology1.09063602
82MP0004185_abnormal_adipocyte_glucose1.08707594
83MP0000762_abnormal_tongue_morphology1.08376048
84MP0000678_abnormal_parathyroid_gland1.08220434
85MP0002697_abnormal_eye_size1.07953824
86MP0002115_abnormal_skeleton_extremities1.06855276
87MP0004134_abnormal_chest_morphology1.05110298
88MP0002896_abnormal_bone_mineralization1.04965385
89MP0001915_intracranial_hemorrhage1.03121753
90MP0001730_embryonic_growth_arrest1.03041232
91MP0004270_analgesia1.02350589
92* MP0002086_abnormal_extraembryonic_tissu1.01727647
93MP0002269_muscular_atrophy1.01378851
94MP0004145_abnormal_muscle_electrophysio1.00672656
95MP0003566_abnormal_cell_adhesion0.99879338
96MP0000266_abnormal_heart_morphology0.99357443
97MP0002234_abnormal_pharynx_morphology0.98882678
98MP0000750_abnormal_muscle_regeneration0.97980984
99MP0002092_abnormal_eye_morphology0.96905290
100MP0002113_abnormal_skeleton_development0.96325794
101MP0003315_abnormal_perineum_morphology0.96248232
102MP0009697_abnormal_copulation0.92194280
103MP0002089_abnormal_postnatal_growth/wei0.92086328
104MP0001958_emphysema0.92084064
105MP0001286_abnormal_eye_development0.92063766
106MP0001849_ear_inflammation0.91963539
107MP0000759_abnormal_skeletal_muscle0.91586811
108MP0002177_abnormal_outer_ear0.91281596
109MP0004087_abnormal_muscle_fiber0.90603758
110MP0008932_abnormal_embryonic_tissue0.89878797
111MP0005257_abnormal_intraocular_pressure0.89670502
112MP0003077_abnormal_cell_cycle0.89417893
113MP0001177_atelectasis0.86831196
114MP0000350_abnormal_cell_proliferation0.85818811
115MP0005369_muscle_phenotype0.85506332
116MP0002106_abnormal_muscle_physiology0.85115629
117MP0008775_abnormal_heart_ventricle0.84794052
118MP0004957_abnormal_blastocyst_morpholog0.84565439
119MP0001340_abnormal_eyelid_morphology0.84380339
120MP0000955_abnormal_spinal_cord0.84122882
121MP0000751_myopathy0.83990166
122MP0003861_abnormal_nervous_system0.83271797
123MP0002152_abnormal_brain_morphology0.83168191
124MP0003111_abnormal_nucleus_morphology0.82765651
125MP0001879_abnormal_lymphatic_vessel0.82246019
126MP0003091_abnormal_cell_migration0.82012154
127MP0002128_abnormal_blood_circulation0.82002480
128* MP0002081_perinatal_lethality0.81543187
129MP0008007_abnormal_cellular_replicative0.80902745
130MP0005197_abnormal_uvea_morphology0.78591002
131MP0005670_abnormal_white_adipose0.78326192
132MP0002080_prenatal_lethality0.77396481
133MP0002009_preneoplasia0.76382705
134MP0001614_abnormal_blood_vessel0.73586132
135MP0004085_abnormal_heartbeat0.71858260
136MP0002184_abnormal_innervation0.71784829

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.93690678
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.93690678
3Protrusio acetabuli (HP:0003179)4.49269052
4Abnormality of the 4th metacarpal (HP:0010012)4.15699516
5Shallow orbits (HP:0000586)3.85371164
6Renal duplication (HP:0000075)3.59071782
7Premature rupture of membranes (HP:0001788)3.38365310
8Asymmetry of the thorax (HP:0001555)2.99997615
9Broad metatarsal (HP:0001783)2.91265642
10Cortical dysplasia (HP:0002539)2.87059971
11Ankle contracture (HP:0006466)2.81884666
12Midline defect of the nose (HP:0004122)2.77859716
13Mesomelia (HP:0003027)2.76910965
14Hepatoblastoma (HP:0002884)2.74239126
15Obstructive sleep apnea (HP:0002870)2.70924401
16Bladder diverticulum (HP:0000015)2.63320434
17Broad thumb (HP:0011304)2.49530764
18Aortic dissection (HP:0002647)2.46911028
19Short middle phalanx of the 5th finger (HP:0004220)2.44990474
20Cerebral aneurysm (HP:0004944)2.44508828
21Syringomyelia (HP:0003396)2.43934379
22Spinal cord lesions (HP:0100561)2.43934379
23Short 5th finger (HP:0009237)2.43736050
24Broad toe (HP:0001837)2.43560861
25Insomnia (HP:0100785)2.42036818
26Muscle fiber inclusion bodies (HP:0100299)2.35373853
27Buphthalmos (HP:0000557)2.35323198
28Mitral valve prolapse (HP:0001634)2.34900224
29Neonatal hypoglycemia (HP:0001998)2.33990825
30Type 1 muscle fiber predominance (HP:0003803)2.33507390
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33030656
32Nemaline bodies (HP:0003798)2.30989870
33Broad long bones (HP:0005622)2.28908198
34Aortic aneurysm (HP:0004942)2.28788751
35Soft skin (HP:0000977)2.26747020
36Deviation of the hallux (HP:0010051)2.26138716
37Abnormality of dentin (HP:0010299)2.24562587
38Broad phalanges of the hand (HP:0009768)2.22682786
39Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.22450656
40Exercise-induced muscle cramps (HP:0003710)2.22152505
41Coronal craniosynostosis (HP:0004440)2.22095803
42Cutaneous finger syndactyly (HP:0010554)2.21563357
43Broad phalanx (HP:0006009)2.20353907
44Overriding aorta (HP:0002623)2.19240407
45Broad finger (HP:0001500)2.18573815
46Wide anterior fontanel (HP:0000260)2.18538086
47Exercise-induced myalgia (HP:0003738)2.17972399
48Abnormality of the parietal bone (HP:0002696)2.17255275
49Calf muscle hypertrophy (HP:0008981)2.16250232
50Choanal stenosis (HP:0000452)2.14318118
51Dilatation of the ascending aorta (HP:0005111)2.14233644
52Wrist flexion contracture (HP:0001239)2.11692476
53Elfin facies (HP:0004428)2.11691658
54Abnormality of the phalanges of the hallux (HP:0010057)2.11307326
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.11099299
56Muscle hypertrophy of the lower extremities (HP:0008968)2.11037937
57Hallux valgus (HP:0001822)2.10887696
58Selective tooth agenesis (HP:0001592)2.09941551
59Lymphangioma (HP:0100764)2.08081816
60Microglossia (HP:0000171)2.06389620
61Diastasis recti (HP:0001540)2.06164087
62Bowel diverticulosis (HP:0005222)2.05249264
63Sparse lateral eyebrow (HP:0005338)2.04970519
64Neonatal short-limb short stature (HP:0008921)2.04533643
65Morphological abnormality of the middle ear (HP:0008609)2.04454203
66Cutaneous syndactyly (HP:0012725)2.03927893
67Glossoptosis (HP:0000162)2.03843670
68Increased connective tissue (HP:0009025)2.02207563
69Abnormality of the calcaneus (HP:0008364)2.02087851
70Trigonocephaly (HP:0000243)2.00992224
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.99278727
72Subacute progressive viral hepatitis (HP:0006572)1.96535780
73Renovascular hypertension (HP:0100817)1.96121913
74Increased variability in muscle fiber diameter (HP:0003557)1.93542266
75Increased nuchal translucency (HP:0010880)1.93277697
76Abnormality of skeletal muscle fiber size (HP:0012084)1.90976690
77Hammertoe (HP:0001765)1.90607672
78Broad palm (HP:0001169)1.88939597
79Hypoplastic ischia (HP:0003175)1.88625053
80Hyperacusis (HP:0010780)1.87620364
81Precocious puberty (HP:0000826)1.87451478
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86875548
83Long palpebral fissure (HP:0000637)1.84674676
84Flat cornea (HP:0007720)1.83909294
85Vertebral arch anomaly (HP:0008438)1.82772766
86Subaortic stenosis (HP:0001682)1.81625183
87Abnormality of the left ventricular outflow tract (HP:0011103)1.81625183
88Calcaneovalgus deformity (HP:0001848)1.81318249
89Atresia of the external auditory canal (HP:0000413)1.79600025
90Advanced eruption of teeth (HP:0006288)1.79439482
91Blue sclerae (HP:0000592)1.79239593
92Skull defect (HP:0001362)1.78930572
93Hip contracture (HP:0003273)1.78914775
94Atrophic scars (HP:0001075)1.78578925
95Cervical subluxation (HP:0003308)1.78493819
96Aplasia involving bones of the extremities (HP:0009825)1.78190933
97Aplasia involving bones of the upper limbs (HP:0009823)1.78190933
98Aplasia of the phalanges of the hand (HP:0009802)1.78190933
99Long eyelashes (HP:0000527)1.77857753
100Broad hallux (HP:0010055)1.77650180
101Camptodactyly of toe (HP:0001836)1.77013419
102Abnormality of the 2nd finger (HP:0004100)1.76185969
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.76040949
104Spinal rigidity (HP:0003306)1.75657268
105Bicuspid aortic valve (HP:0001647)1.75355105
106Missing ribs (HP:0000921)1.75293916
107Bifid tongue (HP:0010297)1.73576780
108Thin bony cortex (HP:0002753)1.73337628
109Vertebral clefting (HP:0008428)1.72999246
110Genu recurvatum (HP:0002816)1.72922834
111Neurofibrillary tangles (HP:0002185)1.72580929
112Exostoses (HP:0100777)1.72228389
113Broad ribs (HP:0000885)1.72213937
114Disproportionate tall stature (HP:0001519)1.72054580
115Ankyloglossia (HP:0010296)1.71606249
116Preaxial foot polydactyly (HP:0001841)1.71060397
117Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70621809
118Joint laxity (HP:0001388)1.70047258
119Narrow palate (HP:0000189)1.69083958
120Mildly elevated creatine phosphokinase (HP:0008180)1.68448774
121Rectal prolapse (HP:0002035)1.67938706
122Hypoplasia of the maxilla (HP:0000327)1.67643660
123Supernumerary ribs (HP:0005815)1.67317705
124Hypoplastic labia majora (HP:0000059)1.67154097
125Hyporeflexia of lower limbs (HP:0002600)1.67031700
126Overgrowth (HP:0001548)1.67030018
127Wormian bones (HP:0002645)1.66513934
128Cerebral inclusion bodies (HP:0100314)1.66131548
129Arnold-Chiari malformation (HP:0002308)1.66058391
130Fragile skin (HP:0001030)1.65864500
131Embryonal renal neoplasm (HP:0011794)1.65552251
132Nephroblastoma (Wilms tumor) (HP:0002667)1.65163058
133Bell-shaped thorax (HP:0001591)1.64115289
134Back pain (HP:0003418)1.64025131
135Colon cancer (HP:0003003)1.63682638
136Scapular winging (HP:0003691)1.63224436
137Dysmetric saccades (HP:0000641)1.63008434
138Abnormal number of incisors (HP:0011064)1.62879765
139Abnormality of the pubic bones (HP:0003172)1.62496918
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.61748829
141Abnormality of the calf musculature (HP:0001430)1.61420915
142Lower limb amyotrophy (HP:0007210)1.61134390
143Vitreoretinal degeneration (HP:0000655)1.61030847
144Arterial tortuosity (HP:0005116)1.60374802
145Turricephaly (HP:0000262)1.59262509
146Anal stenosis (HP:0002025)1.58629887
147Abnormality of the fingertips (HP:0001211)1.58165078
148Abnormality of the aortic arch (HP:0012303)1.56373931
149Thin ribs (HP:0000883)1.55489967
150Bronchomalacia (HP:0002780)1.54799771
151Pseudobulbar signs (HP:0002200)1.53902934
152Broad face (HP:0000283)1.53404506
153Deformed tarsal bones (HP:0008119)1.53145988
154Termporal pattern (HP:0011008)1.51458062
155Insidious onset (HP:0003587)1.51458062
156Myopathic facies (HP:0002058)1.50682050
157Ulnar bowing (HP:0003031)1.50047014
158Muscle fiber splitting (HP:0003555)1.49816298
159Midface retrusion (HP:0011800)1.49730217
160Absent eyebrow (HP:0002223)1.49284120
161Generalized hypotonia (HP:0001290)1.49101341
162Germ cell neoplasia (HP:0100728)1.49081627
163Patellar dislocation (HP:0002999)1.48022134
164Protruding ear (HP:0000411)1.47123606
165Myotonia (HP:0002486)1.47081017
166Distal lower limb amyotrophy (HP:0008944)1.46726038
167Difficulty running (HP:0009046)1.46387947
168Pterygium (HP:0001059)1.46263231
169Abnormality of the diencephalon (HP:0010662)1.44955910
170Narrow face (HP:0000275)1.44780633
171Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.43739977
172Mask-like facies (HP:0000298)1.42955621
173Upper limb amyotrophy (HP:0009129)1.41964999
174Distal upper limb amyotrophy (HP:0007149)1.41964999
175High anterior hairline (HP:0009890)1.41940191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.78077653
2PKN23.21049750
3AKT33.18560418
4DDR22.96048808
5MAP3K102.90337665
6PDGFRA2.85646418
7ERBB42.73352085
8TRIB32.72580189
9TTN2.57521806
10LATS22.54776348
11EPHB22.54370386
12CDC72.32727656
13MKNK12.18036802
14NTRK12.12926445
15PASK1.99971012
16CDK121.99642383
17MARK11.77536804
18FGFR11.70246834
19PTK61.68454617
20TGFBR11.67247487
21STK31.66156803
22PHKG21.65425011
23PHKG11.65425011
24PAK41.59826248
25SIK11.55138825
26EEF2K1.54213109
27PAK21.52745604
28STK38L1.50919079
29TAF11.50402443
30RIPK11.48987123
31PNCK1.47673964
32CASK1.44254713
33NEK11.43283058
34DMPK1.39636614
35NEK21.34634587
36SMG11.30201846
37TYRO31.28109229
38ERBB31.26741983
39MKNK21.26087475
40OBSCN1.24573318
41BRD41.23332184
42* MTOR1.20393008
43TTK1.17429119
44EPHA31.16968615
45NTRK31.16000792
46ILK1.07172773
47FGFR21.06026601
48PLK31.05908692
49ICK1.05727547
50PTK21.04745438
51EIF2AK11.02875168
52RPS6KB21.01458902
53SGK21.01377012
54KSR11.01129198
55CDK61.00708959
56PBK1.00478778
57PRKD20.98615410
58ERBB20.98043821
59SCYL20.97932243
60SGK4940.95280827
61SGK2230.95280827
62SRPK10.95015313
63PRKD30.91222299
64PDGFRB0.89962964
65SGK30.89003796
66WEE10.87503724
67CDC42BPA0.86620004
68FER0.85481890
69TSSK60.84172344
70BRSK20.82259140
71CAMK1G0.79725963
72TIE10.79483140
73MAP3K80.79404925
74MET0.79046910
75CAMK1D0.78528097
76ROCK10.77846571
77CDK70.77016069
78RPS6KA40.76731704
79PAK30.76462276
80CDK40.76120090
81PRKCH0.75286506
82STK390.73491494
83MAP2K40.71756456
84CHEK10.71088850
85FLT30.70194625
86LRRK20.69876181
87MELK0.69685936
88AURKB0.69578301
89ATR0.68662100
90MAP3K90.68606556
91WNK30.67596953
92PLK10.67089764
93MAPK130.66123111
94MAP3K60.65757748
95BMX0.63812845
96KSR20.63303495
97BUB10.62160480
98ALK0.61282260
99AKT20.60929809
100CHEK20.60475136
101ATM0.59183823
102TGFBR20.56988594
103EPHA20.56968542
104PIK3CA0.55921979
105PAK60.55908052
106PLK20.55747863
107LIMK10.55407367
108ZAK0.54866187
109RPS6KA20.54826996
110WNK10.54811609
111CSNK1A1L0.54423378
112NEK90.53718147
113CDK20.53655571
114PKN10.53605907
115STK40.53419724
116STK240.53285664
117PTK2B0.49802789
118* CDK10.49584259
119VRK20.49134865
120MOS0.48410708
121BRSK10.47034124
122EPHA40.47025120
123MAPK100.46461858
124CDK80.44897578
125CSNK1E0.43902828
126UHMK10.43569336
127CDK150.42842834
128TESK10.42322324
129DYRK30.41383321
130KDR0.41340199
131PRKDC0.41285451
132CDK11A0.41265143
133CSNK1G10.40802885
134MYLK0.40680696
135BRAF0.39882822
136CDK180.38884113
137* AKT10.38818782
138PRKAA20.38681526
139LMTK20.38076422
140IRAK30.37796684
141ROCK20.37650646
142STK380.35703081
143PRKAA10.35520659
144NTRK20.34346966
145DYRK20.34150505
146MARK20.33358081
147MINK10.32495420
148CDK140.31971255
149RET0.31005999

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.43489988
2Hedgehog signaling pathway_Homo sapiens_hsa043402.85412129
3Hippo signaling pathway_Homo sapiens_hsa043902.76987682
4ECM-receptor interaction_Homo sapiens_hsa045122.47521813
5Cell cycle_Homo sapiens_hsa041102.38109679
6Adherens junction_Homo sapiens_hsa045202.35900014
7Focal adhesion_Homo sapiens_hsa045102.12544368
8Dilated cardiomyopathy_Homo sapiens_hsa054142.11846270
9TGF-beta signaling pathway_Homo sapiens_hsa043502.11486428
10Proteoglycans in cancer_Homo sapiens_hsa052052.10655761
11MicroRNAs in cancer_Homo sapiens_hsa052062.04402673
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.02257056
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.94983658
14Spliceosome_Homo sapiens_hsa030401.92382391
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91123340
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89493753
17Wnt signaling pathway_Homo sapiens_hsa043101.81638284
18RNA transport_Homo sapiens_hsa030131.77479759
19mRNA surveillance pathway_Homo sapiens_hsa030151.73833391
20Protein digestion and absorption_Homo sapiens_hsa049741.71894926
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62458223
22Tight junction_Homo sapiens_hsa045301.57242012
23Prion diseases_Homo sapiens_hsa050201.56615980
24Viral myocarditis_Homo sapiens_hsa054161.55373860
25Small cell lung cancer_Homo sapiens_hsa052221.54539637
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52805082
27Notch signaling pathway_Homo sapiens_hsa043301.47885790
28Chronic myeloid leukemia_Homo sapiens_hsa052201.45227629
29Biosynthesis of amino acids_Homo sapiens_hsa012301.43540539
30Melanogenesis_Homo sapiens_hsa049161.41762320
31Arginine and proline metabolism_Homo sapiens_hsa003301.41644545
32Colorectal cancer_Homo sapiens_hsa052101.39283674
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37209409
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36444802
35Axon guidance_Homo sapiens_hsa043601.35910081
36Lysine degradation_Homo sapiens_hsa003101.34849021
37HTLV-I infection_Homo sapiens_hsa051661.34042159
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31243631
39Oocyte meiosis_Homo sapiens_hsa041141.31026017
40Bladder cancer_Homo sapiens_hsa052191.30617301
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29010408
42Systemic lupus erythematosus_Homo sapiens_hsa053221.27256982
43Pathways in cancer_Homo sapiens_hsa052001.26977891
44Arginine biosynthesis_Homo sapiens_hsa002201.22896535
45Vitamin B6 metabolism_Homo sapiens_hsa007501.21495686
46Prostate cancer_Homo sapiens_hsa052151.19814396
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.18390102
48DNA replication_Homo sapiens_hsa030301.17491949
49Endometrial cancer_Homo sapiens_hsa052131.15763576
50Thyroid cancer_Homo sapiens_hsa052161.13739383
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11006595
52Viral carcinogenesis_Homo sapiens_hsa052031.10109505
53Pyruvate metabolism_Homo sapiens_hsa006201.09815896
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05152016
55Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05078955
56Melanoma_Homo sapiens_hsa052181.04734357
57mTOR signaling pathway_Homo sapiens_hsa041501.04594755
58Phenylalanine metabolism_Homo sapiens_hsa003601.03460116
59p53 signaling pathway_Homo sapiens_hsa041151.03036564
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01882114
61Mismatch repair_Homo sapiens_hsa034301.00612719
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00429505
63Amoebiasis_Homo sapiens_hsa051460.99653642
64Alcoholism_Homo sapiens_hsa050340.98873933
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98224562
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96419923
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96302883
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95956950
69Carbon metabolism_Homo sapiens_hsa012000.95901174
70RNA degradation_Homo sapiens_hsa030180.93094952
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92192202
72Glioma_Homo sapiens_hsa052140.91978418
73VEGF signaling pathway_Homo sapiens_hsa043700.91563671
74Fatty acid biosynthesis_Homo sapiens_hsa000610.91316493
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.90719480
76One carbon pool by folate_Homo sapiens_hsa006700.87511340
77Rap1 signaling pathway_Homo sapiens_hsa040150.86041621
78Long-term potentiation_Homo sapiens_hsa047200.85551172
79Fatty acid metabolism_Homo sapiens_hsa012120.84955976
80Renal cell carcinoma_Homo sapiens_hsa052110.83560292
81Gap junction_Homo sapiens_hsa045400.82764059
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81619584
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81248331
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80931690
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80821207
86Glucagon signaling pathway_Homo sapiens_hsa049220.79210997
87Estrogen signaling pathway_Homo sapiens_hsa049150.78804386
88Choline metabolism in cancer_Homo sapiens_hsa052310.78282996
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77973616
90Cocaine addiction_Homo sapiens_hsa050300.77304448
91Bile secretion_Homo sapiens_hsa049760.77130068
92Pancreatic cancer_Homo sapiens_hsa052120.74204562
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73235560
94Amphetamine addiction_Homo sapiens_hsa050310.72823213
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.71465437
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.70836011
97Base excision repair_Homo sapiens_hsa034100.70579137
98HIF-1 signaling pathway_Homo sapiens_hsa040660.70396218
99Non-small cell lung cancer_Homo sapiens_hsa052230.69857720
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67747485
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67710639
102AMPK signaling pathway_Homo sapiens_hsa041520.66894209
103Nucleotide excision repair_Homo sapiens_hsa034200.66814445
104Insulin resistance_Homo sapiens_hsa049310.65897036
105Insulin signaling pathway_Homo sapiens_hsa049100.65055844
106Dopaminergic synapse_Homo sapiens_hsa047280.63596187
107FoxO signaling pathway_Homo sapiens_hsa040680.63499581
108Cardiac muscle contraction_Homo sapiens_hsa042600.62404531
109Circadian rhythm_Homo sapiens_hsa047100.61645022
110Histidine metabolism_Homo sapiens_hsa003400.59031188
111Glutamatergic synapse_Homo sapiens_hsa047240.58745117
112Platelet activation_Homo sapiens_hsa046110.58342905
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56755515
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56108119
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.55192971
116Propanoate metabolism_Homo sapiens_hsa006400.51819968
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50727697
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50622708
119Vibrio cholerae infection_Homo sapiens_hsa051100.50534640
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50462783
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50324088
122GnRH signaling pathway_Homo sapiens_hsa049120.49263315
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49005191
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46910034
125Dorso-ventral axis formation_Homo sapiens_hsa043200.46185869
126Hepatitis B_Homo sapiens_hsa051610.45937098
127Thyroid hormone synthesis_Homo sapiens_hsa049180.41545945
128Type II diabetes mellitus_Homo sapiens_hsa049300.37715672
129MAPK signaling pathway_Homo sapiens_hsa040100.36604397
130ErbB signaling pathway_Homo sapiens_hsa040120.36545258
131Oxytocin signaling pathway_Homo sapiens_hsa049210.36461709
132Epstein-Barr virus infection_Homo sapiens_hsa051690.35273973
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.34534569
134Renin-angiotensin system_Homo sapiens_hsa046140.32437842
135Fanconi anemia pathway_Homo sapiens_hsa034600.32261677

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