GRB14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.69904106
2ensheathment of neurons (GO:0007272)6.79538361
3axon ensheathment (GO:0008366)6.79538361
4myelination (GO:0042552)6.76942060
5blood coagulation, intrinsic pathway (GO:0007597)5.91537650
6protein neddylation (GO:0045116)5.73567649
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.39212745
8long-chain fatty acid biosynthetic process (GO:0042759)5.28674319
9creatine metabolic process (GO:0006600)5.01228134
10aromatic amino acid family catabolic process (GO:0009074)4.84716183
11negative regulation of neurotransmitter secretion (GO:0046929)4.78201542
12myelin maintenance (GO:0043217)4.62050296
13cholesterol biosynthetic process (GO:0006695)4.60070887
14reverse cholesterol transport (GO:0043691)4.54641605
15oligodendrocyte differentiation (GO:0048709)4.45179735
16glyoxylate metabolic process (GO:0046487)4.41197335
17high-density lipoprotein particle remodeling (GO:0034375)4.35219100
18drug catabolic process (GO:0042737)4.28131477
19glycerophospholipid catabolic process (GO:0046475)4.27464459
20negative regulation of protein localization to cell surface (GO:2000009)4.24688725
21adhesion of symbiont to host cell (GO:0044650)4.20407260
22virion attachment to host cell (GO:0019062)4.20407260
23apical protein localization (GO:0045176)4.15318670
24epoxygenase P450 pathway (GO:0019373)4.14667414
25establishment of mitochondrion localization (GO:0051654)4.11977009
26sterol biosynthetic process (GO:0016126)4.07240803
27negative regulation of neurotransmitter transport (GO:0051589)4.02855772
28long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.02582343
29astrocyte development (GO:0014002)4.01768491
30asymmetric protein localization (GO:0008105)4.01025913
31response to redox state (GO:0051775)4.00874327
32photoreceptor cell differentiation (GO:0046530)3.95538186
33eye photoreceptor cell differentiation (GO:0001754)3.95538186
34exogenous drug catabolic process (GO:0042738)3.89845217
35tyrosine metabolic process (GO:0006570)3.89038257
36phenylpropanoid metabolic process (GO:0009698)3.88144257
37fibrinolysis (GO:0042730)3.87990813
38regulation of fibrinolysis (GO:0051917)3.84269819
39phospholipid homeostasis (GO:0055091)3.83913143
40acylglycerol homeostasis (GO:0055090)3.83668389
41triglyceride homeostasis (GO:0070328)3.83668389
42substantia nigra development (GO:0021762)3.83054114
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78565436
44L-phenylalanine catabolic process (GO:0006559)3.78565436
45regulation of collateral sprouting (GO:0048670)3.76404878
46peptidyl-tyrosine autophosphorylation (GO:0038083)3.75349445
47fatty-acyl-CoA biosynthetic process (GO:0046949)3.72409077
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.71795563
49presynaptic membrane organization (GO:0097090)3.69093094
50regulation of protein activation cascade (GO:2000257)3.68486649
51xenobiotic catabolic process (GO:0042178)3.67502096
52peptidyl-glutamic acid carboxylation (GO:0017187)3.66986790
53protein carboxylation (GO:0018214)3.66986790
54positive regulation of action potential (GO:0045760)3.66319760
55amyloid precursor protein metabolic process (GO:0042982)3.63470385
56presynaptic membrane assembly (GO:0097105)3.61829879
57cellular glucuronidation (GO:0052695)3.58696491
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.56960242
59bile acid biosynthetic process (GO:0006699)3.56903638
60low-density lipoprotein particle remodeling (GO:0034374)3.56586940
61omega-hydroxylase P450 pathway (GO:0097267)3.56337167
62negative regulation of norepinephrine secretion (GO:0010700)3.53324561
63regulation of complement activation (GO:0030449)3.49850219
64dopamine transport (GO:0015872)3.48190786
65serine family amino acid catabolic process (GO:0009071)3.48028717
66fatty-acyl-CoA metabolic process (GO:0035337)3.45859400
67negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.42471501
68uronic acid metabolic process (GO:0006063)3.41528561
69glucuronate metabolic process (GO:0019585)3.41528561
70myelination in peripheral nervous system (GO:0022011)3.40138306
71peripheral nervous system axon ensheathment (GO:0032292)3.40138306
72S-adenosylmethionine metabolic process (GO:0046500)3.39853362
73adhesion of symbiont to host (GO:0044406)3.39785063
74membrane tubulation (GO:0097320)3.38037659
75isoprenoid biosynthetic process (GO:0008299)3.36781814
76negative regulation of blood coagulation (GO:0030195)3.36411781
77negative regulation of hemostasis (GO:1900047)3.36411781
78import into cell (GO:0098657)3.34593314
79very long-chain fatty acid metabolic process (GO:0000038)3.33520852
80positive regulation of blood coagulation (GO:0030194)3.31576768
81positive regulation of hemostasis (GO:1900048)3.31576768
82complement activation, alternative pathway (GO:0006957)3.29250883
83platelet dense granule organization (GO:0060155)3.28394157
84regulation of hexokinase activity (GO:1903299)3.26976825
85regulation of glucokinase activity (GO:0033131)3.26976825
86thioester biosynthetic process (GO:0035384)3.26038435
87acyl-CoA biosynthetic process (GO:0071616)3.26038435
88negative regulation of JUN kinase activity (GO:0043508)3.24796042
89negative regulation of heart rate (GO:0010459)3.23430428
90androgen biosynthetic process (GO:0006702)3.21622096
91plasma lipoprotein particle remodeling (GO:0034369)3.21070792
92protein-lipid complex remodeling (GO:0034368)3.21070792
93macromolecular complex remodeling (GO:0034367)3.21070792
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19839530
95negative regulation of coagulation (GO:0050819)3.19331392
96L-phenylalanine metabolic process (GO:0006558)3.19201537
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19201537
98regulation of integrin-mediated signaling pathway (GO:2001044)3.17574095
99response to methylmercury (GO:0051597)3.16448791
100negative regulation of response to food (GO:0032096)3.15715857
101negative regulation of appetite (GO:0032099)3.15715857
102oxidative demethylation (GO:0070989)3.15408039
103amino-acid betaine metabolic process (GO:0006577)3.14656940
104cellular response to epinephrine stimulus (GO:0071872)3.14649098
105lactate metabolic process (GO:0006089)3.13712646
106L-amino acid import (GO:0043092)3.13481912
107bile acid metabolic process (GO:0008206)3.13418013
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13246756
109nucleotide transmembrane transport (GO:1901679)3.12921746
110response to lipoprotein particle (GO:0055094)3.10923045
111aromatic amino acid family metabolic process (GO:0009072)3.10800569
112GPI anchor metabolic process (GO:0006505)3.10405978
113negative regulation of wound healing (GO:0061045)3.09839275
114GPI anchor biosynthetic process (GO:0006506)3.08905295
115protein palmitoylation (GO:0018345)3.08165167
116polyketide metabolic process (GO:0030638)3.08075565
117doxorubicin metabolic process (GO:0044598)3.08075565
118daunorubicin metabolic process (GO:0044597)3.08075565
119positive regulation of coagulation (GO:0050820)3.07134161
120amine catabolic process (GO:0009310)3.02694784
121cellular biogenic amine catabolic process (GO:0042402)3.02694784
122regulation of lipoprotein metabolic process (GO:0050746)2.98917085
123drug metabolic process (GO:0017144)2.98344540
124negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.97289592
125thrombin receptor signaling pathway (GO:0070493)2.93424044
126positive regulation of cellular amine metabolic process (GO:0033240)2.93192901
127water-soluble vitamin biosynthetic process (GO:0042364)2.93103796
128axon development (GO:0061564)2.91428055
129negative regulation of fibrinolysis (GO:0051918)2.90960940
130ethanol oxidation (GO:0006069)2.89507464
131aminoglycoside antibiotic metabolic process (GO:0030647)2.86298113
132amyloid precursor protein catabolic process (GO:0042987)2.85735336
133glycosylceramide metabolic process (GO:0006677)2.85108320
134regulation of Golgi to plasma membrane protein transport (GO:0042996)2.84583373
135arginine metabolic process (GO:0006525)2.82638894
136magnesium ion transport (GO:0015693)2.80339752
137limb bud formation (GO:0060174)2.78650987
138glycine metabolic process (GO:0006544)2.78559928
139interleukin-6-mediated signaling pathway (GO:0070102)2.78169947
140response to epinephrine (GO:0071871)2.77454696
141protein activation cascade (GO:0072376)2.76806637
142heme transport (GO:0015886)2.76283974
143amino acid salvage (GO:0043102)2.75211053
144L-methionine salvage (GO:0071267)2.75211053
145L-methionine biosynthetic process (GO:0071265)2.75211053
146regulation of cholesterol esterification (GO:0010872)2.75182440
147cerebral cortex radially oriented cell migration (GO:0021799)2.74678749
148arginine catabolic process (GO:0006527)2.73454655
149Leydig cell differentiation (GO:0033327)2.72499417
150alpha-amino acid catabolic process (GO:1901606)2.72417758
151negative regulation of sterol transport (GO:0032372)2.71787735
152negative regulation of cholesterol transport (GO:0032375)2.71787735
153preassembly of GPI anchor in ER membrane (GO:0016254)2.70996651
154beta-amyloid metabolic process (GO:0050435)2.69954419
155urate metabolic process (GO:0046415)2.69699749
156regulation of hemostasis (GO:1900046)2.68380266
157regulation of blood coagulation (GO:0030193)2.68380266
158benzene-containing compound metabolic process (GO:0042537)2.67920255
159transmission of nerve impulse (GO:0019226)2.67877341
160negative regulation of axonogenesis (GO:0050771)2.67875085
161peptidyl-glutamic acid modification (GO:0018200)2.67863668
162positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67125803
163aldehyde catabolic process (GO:0046185)2.66263653
164indole-containing compound catabolic process (GO:0042436)2.65663328
165indolalkylamine catabolic process (GO:0046218)2.65663328
166tryptophan catabolic process (GO:0006569)2.65663328
167peptidyl-cysteine modification (GO:0018198)2.62806794
168positive regulation of glial cell differentiation (GO:0045687)2.60929714
169leukocyte migration involved in inflammatory response (GO:0002523)2.60821190
170adult walking behavior (GO:0007628)2.58548053
171negative regulation of acute inflammatory response (GO:0002674)2.58520935
172membrane assembly (GO:0071709)2.55581842
173iron coordination entity transport (GO:1901678)2.55327878
174negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54576717
175response to lead ion (GO:0010288)2.54439776
176glutathione biosynthetic process (GO:0006750)2.52622435
177acyl-CoA metabolic process (GO:0006637)2.52013034
178thioester metabolic process (GO:0035383)2.52013034
179peripheral nervous system development (GO:0007422)2.51372395
180neuron remodeling (GO:0016322)2.51359922
181glial cell development (GO:0021782)2.50875338
182neural nucleus development (GO:0048857)2.48537400
183ear development (GO:0043583)2.44155880
184neuron cell-cell adhesion (GO:0007158)2.43979542
185respiratory electron transport chain (GO:0022904)2.43724576
186Golgi to plasma membrane protein transport (GO:0043001)2.43610436
187membrane raft organization (GO:0031579)2.42399062
188protein localization to endosome (GO:0036010)2.41031260
189mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39950307
190cellular response to catecholamine stimulus (GO:0071870)2.39920734
191central nervous system myelination (GO:0022010)10.7149946
192axon ensheathment in central nervous system (GO:0032291)10.7149946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse2.95781846
2* GBX2_23144817_ChIP-Seq_PC3_Human2.75942220
3* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.53801111
4TAF15_26573619_Chip-Seq_HEK293_Human2.36742733
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.25269961
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18084108
7IGF1R_20145208_ChIP-Seq_DFB_Human2.02287662
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01804681
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01737421
10JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92853358
11EZH2_27294783_Chip-Seq_NPCs_Mouse1.89191543
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.88380663
13EWS_26573619_Chip-Seq_HEK293_Human1.87588390
14SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87117776
15* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86008118
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84429768
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83337683
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82251100
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78372738
20BCAT_22108803_ChIP-Seq_LS180_Human1.78071603
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.74886190
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74343246
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74343246
24ER_23166858_ChIP-Seq_MCF-7_Human1.73687097
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73377685
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73097923
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70267047
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68791257
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.66089951
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65903094
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.65336354
32VDR_22108803_ChIP-Seq_LS180_Human1.65004396
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.64797566
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.62728996
35* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62709181
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61839841
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61295274
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.58098138
39* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53486858
40* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51179301
41* AR_25329375_ChIP-Seq_VCAP_Human1.50145189
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49119580
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.46739800
44AR_21572438_ChIP-Seq_LNCaP_Human1.45531253
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44514417
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43422684
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43350555
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42053288
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.42024945
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40546470
51* P53_22387025_ChIP-Seq_ESCs_Mouse1.40323463
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40265210
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39793561
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39149862
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.38236013
56DROSHA_22980978_ChIP-Seq_HELA_Human1.37773306
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37486534
58* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37186286
59CDX2_22108803_ChIP-Seq_LS180_Human1.36246013
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36081214
61* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35397724
62* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35397724
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35097688
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34988521
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34896540
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.34065011
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33904666
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32782414
69* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30954048
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29398366
71TCF4_22108803_ChIP-Seq_LS180_Human1.28363560
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26728267
73* E2F1_18555785_Chip-Seq_ESCs_Mouse1.25657969
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24626377
75ZNF274_21170338_ChIP-Seq_K562_Hela1.24512096
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23962634
77* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23044481
78HTT_18923047_ChIP-ChIP_STHdh_Human1.22926218
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22675889
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.21293736
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21082933
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20004680
83EZH2_22144423_ChIP-Seq_EOC_Human1.19954018
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18573774
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17698247
86* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16113839
87* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15647458
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15145378
89PHF8_20622853_ChIP-Seq_HELA_Human1.12989253
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12120391
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11919410
92AR_20517297_ChIP-Seq_VCAP_Human1.11757577
93P300_19829295_ChIP-Seq_ESCs_Human1.11315276
94GATA4_25053715_ChIP-Seq_YYC3_Human1.10573761
95* SOX2_18555785_Chip-Seq_ESCs_Mouse1.10197247
96* SOX2_20726797_ChIP-Seq_SW620_Human1.10184865
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09827085
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.09289613
99FUS_26573619_Chip-Seq_HEK293_Human1.09017951
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.07868174
101NFYA_21822215_ChIP-Seq_K562_Human1.07519462
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07224288
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.07224288
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06494756
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06296709
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05670046
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05530801
108* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05313073
109* LXR_22158963_ChIP-Seq_LIVER_Mouse1.05081852
110EOMES_21245162_ChIP-Seq_HESCs_Human1.04987257
111* NMYC_18555785_Chip-Seq_ESCs_Mouse1.04391196
112PU1_27457419_Chip-Seq_LIVER_Mouse1.03801770
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03799580
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03399173
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03300455
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03001427
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02597949
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02364567
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02058864
120STAT3_23295773_ChIP-Seq_U87_Human1.01955891
121HNFA_21074721_ChIP-Seq_CACO-2_Human1.01530657
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00295501
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00200642
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00157927
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.00114199
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99702299
127RBPJ_21746931_ChIP-Seq_IB4_Human0.99472745
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.98352940
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97291286
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93629475
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93362532
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92712487
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91833137
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91614329
135TCF4_23295773_ChIP-Seq_U87_Human0.91135885
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90262767
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89078394
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89075040
139* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88404576
140CBP_21632823_ChIP-Seq_H3396_Human0.88062396
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87993575
142TBL1_22424771_ChIP-Seq_293T_Human0.87823452
143* RARB_27405468_Chip-Seq_BRAIN_Mouse0.85774061
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84664253
145* SMAD4_21799915_ChIP-Seq_A2780_Human0.84615973
146* SOX2_19829295_ChIP-Seq_ESCs_Human0.83771905
147* NANOG_19829295_ChIP-Seq_ESCs_Human0.83771905
148* NANOG_18555785_Chip-Seq_ESCs_Mouse0.83423508
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.82932606
150* P300_18555785_Chip-Seq_ESCs_Mouse0.82842795
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82672459
152* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81798949
153PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81398825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.45195954
2MP0005464_abnormal_platelet_physiology4.33162044
3MP0003950_abnormal_plasma_membrane3.96708921
4MP0005365_abnormal_bile_salt3.62372011
5MP0003690_abnormal_glial_cell3.12379209
6MP0003880_abnormal_central_pattern3.08151092
7MP0004270_analgesia2.95782810
8MP0009780_abnormal_chondrocyte_physiolo2.79039315
9MP0010329_abnormal_lipoprotein_level2.76444464
10MP0003806_abnormal_nucleotide_metabolis2.74025317
11MP0009697_abnormal_copulation2.66640994
12MP0003329_amyloid_beta_deposits2.65706312
13MP0008004_abnormal_stomach_pH2.60383112
14MP0003011_delayed_dark_adaptation2.54432376
15MP0005451_abnormal_body_composition2.52431223
16MP0004885_abnormal_endolymph2.42861695
17MP0005171_absent_coat_pigmentation2.42699040
18MP0001529_abnormal_vocalization2.35553664
19MP0001905_abnormal_dopamine_level2.28062121
20MP0002138_abnormal_hepatobiliary_system2.22936752
21MP0003868_abnormal_feces_composition2.21108298
22MP0003634_abnormal_glial_cell2.21026050
23MP0003252_abnormal_bile_duct2.16133487
24MP0002254_reproductive_system_inflammat2.11727374
25MP0001485_abnormal_pinna_reflex2.09664183
26MP0002272_abnormal_nervous_system2.06522724
27MP0003136_yellow_coat_color2.05805524
28MP0002876_abnormal_thyroid_physiology2.02012736
29MP0004742_abnormal_vestibular_system1.99568148
30MP0001486_abnormal_startle_reflex1.97700816
31MP0008872_abnormal_physiological_respon1.97492871
32MP0005646_abnormal_pituitary_gland1.96204582
33MP0003195_calcinosis1.93892869
34MP0004147_increased_porphyrin_level1.93577189
35MP0004142_abnormal_muscle_tone1.91077590
36MP0001666_abnormal_nutrient_absorption1.88508602
37MP0004043_abnormal_pH_regulation1.86761391
38MP0004215_abnormal_myocardial_fiber1.83399808
39MP0004019_abnormal_vitamin_homeostasis1.81143248
40MP0002229_neurodegeneration1.77884253
41MP0000778_abnormal_nervous_system1.76434700
42MP0005409_darkened_coat_color1.69408406
43MP0003632_abnormal_nervous_system1.68438787
44MP0002736_abnormal_nociception_after1.66859143
45MP0005410_abnormal_fertilization1.66430640
46MP0001661_extended_life_span1.65886080
47MP0000462_abnormal_digestive_system1.64809560
48MP0002064_seizures1.62756535
49MP0003186_abnormal_redox_activity1.61316061
50MP0001984_abnormal_olfaction1.59792259
51MP0001756_abnormal_urination1.57474485
52MP0004036_abnormal_muscle_relaxation1.54255904
53MP0010678_abnormal_skin_adnexa1.51296933
54MP0000747_muscle_weakness1.50587116
55MP0004381_abnormal_hair_follicle1.50018053
56MP0005084_abnormal_gallbladder_morpholo1.49161490
57MP0006036_abnormal_mitochondrial_physio1.48623615
58MP0000383_abnormal_hair_follicle1.47256565
59MP0008775_abnormal_heart_ventricle1.46058748
60MP0002909_abnormal_adrenal_gland1.42971856
61MP0000604_amyloidosis1.42331276
62MP0005187_abnormal_penis_morphology1.41120687
63MP0003941_abnormal_skin_development1.38804894
64MP0010386_abnormal_urinary_bladder1.37814002
65MP0005220_abnormal_exocrine_pancreas1.36599955
66MP0000230_abnormal_systemic_arterial1.36373493
67MP0010368_abnormal_lymphatic_system1.32812003
68MP0008438_abnormal_cutaneous_collagen1.27854612
69MP0009046_muscle_twitch1.27615633
70MP0008877_abnormal_DNA_methylation1.24552439
71MP0002837_dystrophic_cardiac_calcinosis1.21806448
72MP0002734_abnormal_mechanical_nocicepti1.21221664
73MP0004145_abnormal_muscle_electrophysio1.21185859
74MP0002132_abnormal_respiratory_system1.20315982
75MP0003638_abnormal_response/metabolism_1.19968611
76MP0000639_abnormal_adrenal_gland1.19297754
77MP0005551_abnormal_eye_electrophysiolog1.18699087
78MP0004134_abnormal_chest_morphology1.18017790
79MP0000955_abnormal_spinal_cord1.16539467
80MP0003137_abnormal_impulse_conducting1.16286347
81MP0006035_abnormal_mitochondrial_morpho1.15809281
82MP0009745_abnormal_behavioral_response1.15559342
83MP0004859_abnormal_synaptic_plasticity1.15254200
84MP0002295_abnormal_pulmonary_circulatio1.14247935
85MP0001764_abnormal_homeostasis1.13281691
86MP0001299_abnormal_eye_distance/1.13108072
87MP0005408_hypopigmentation1.12924932
88MP0005636_abnormal_mineral_homeostasis1.12701107
89MP0003631_nervous_system_phenotype1.12401114
90MP0004185_abnormal_adipocyte_glucose1.12236193
91MP0000751_myopathy1.11724949
92MP0009840_abnormal_foam_cell1.11678130
93MP0002139_abnormal_hepatobiliary_system1.11229033
94MP0005330_cardiomyopathy1.10939830
95MP0000566_synostosis1.10191993
96MP0003283_abnormal_digestive_organ1.09906361
97MP0002882_abnormal_neuron_morphology1.07267819
98MP0001963_abnormal_hearing_physiology1.05663553
99MP0002102_abnormal_ear_morphology1.05524669
100MP0005386_behavior/neurological_phenoty1.03884204
101MP0004924_abnormal_behavior1.03884204
102MP0001879_abnormal_lymphatic_vessel1.03738449
103MP0001440_abnormal_grooming_behavior1.02570371
104MP0003879_abnormal_hair_cell1.01446210
105MP0008260_abnormal_autophagy1.01444820
106MP0008875_abnormal_xenobiotic_pharmacok1.01353131
107MP0003635_abnormal_synaptic_transmissio1.01059708
108MP0001346_abnormal_lacrimal_gland0.99781002
109MP0005423_abnormal_somatic_nervous0.99600234
110MP0002066_abnormal_motor_capabilities/c0.99491088
111MP0001968_abnormal_touch/_nociception0.98123294
112MP0005360_urolithiasis0.96107482
113MP0006054_spinal_hemorrhage0.95923414
114MP0000749_muscle_degeneration0.95803712
115MP0005623_abnormal_meninges_morphology0.95641843
116MP0002752_abnormal_somatic_nervous0.95610903
117MP0003718_maternal_effect0.94723975
118MP0005085_abnormal_gallbladder_physiolo0.94660517
119MP0005083_abnormal_biliary_tract0.94316297
120MP0002090_abnormal_vision0.93881280
121MP0005167_abnormal_blood-brain_barrier0.92247745
122MP0009642_abnormal_blood_homeostasis0.92209324
123MP0001944_abnormal_pancreas_morphology0.91701723
124MP0005379_endocrine/exocrine_gland_phen0.91438924
125MP0001348_abnormal_lacrimal_gland0.91341480
126MP0000762_abnormal_tongue_morphology0.90272002
127MP0005332_abnormal_amino_acid0.89854273
128MP0004085_abnormal_heartbeat0.89111463
129* MP0002078_abnormal_glucose_homeostasis0.88919284
130MP0005195_abnormal_posterior_eye0.87701558
131MP0002118_abnormal_lipid_homeostasis0.87405394
132MP0008995_early_reproductive_senescence0.86134682
133MP0009643_abnormal_urine_homeostasis0.85779569
134MP0001851_eye_inflammation0.84815540
135MP0005395_other_phenotype0.84572176
136MP0003633_abnormal_nervous_system0.82853573
137MP0000647_abnormal_sebaceous_gland0.80944974
138MP0003953_abnormal_hormone_level0.80693314
139MP0005645_abnormal_hypothalamus_physiol0.80613888
140MP0003937_abnormal_limbs/digits/tail_de0.80250395
141MP0002572_abnormal_emotion/affect_behav0.77777583
142MP0001727_abnormal_embryo_implantation0.77592441
143MP0005647_abnormal_sex_gland0.77376566
144MP0002067_abnormal_sensory_capabilities0.76637037
145MP0004084_abnormal_cardiac_muscle0.76258171
146MP0003938_abnormal_ear_development0.75540712
147MP0008569_lethality_at_weaning0.75183286
148MP0004510_myositis0.74560805
149MP0001970_abnormal_pain_threshold0.72869753
150MP0006276_abnormal_autonomic_nervous0.72812879
151MP0002938_white_spotting0.72016938
152MP0000026_abnormal_inner_ear0.71907763
153MP0004272_abnormal_basement_membrane0.71504415
154MP0005058_abnormal_lysosome_morphology0.71276549
155MP0003122_maternal_imprinting0.70029684
156MP0005319_abnormal_enzyme/_coenzyme0.69043209
157MP0006138_congestive_heart_failure0.68997799
158MP0000467_abnormal_esophagus_morphology0.68275873
159MP0009384_cardiac_valve_regurgitation0.67278807
160MP0005620_abnormal_muscle_contractility0.65381695
161MP0000579_abnormal_nail_morphology0.65108174
162MP0002972_abnormal_cardiac_muscle0.64528388
163MP0005535_abnormal_body_temperature0.64045040
164MP0001765_abnormal_ion_homeostasis0.62144785
165MP0000013_abnormal_adipose_tissue0.62075919
166MP0000609_abnormal_liver_physiology0.60666188
167MP0003566_abnormal_cell_adhesion0.60388176
168MP0002168_other_aberrant_phenotype0.60121428
169MP0000631_abnormal_neuroendocrine_gland0.59647907
170MP0004484_altered_response_of0.58891039
171MP0000358_abnormal_cell_content/0.57826611
172MP0005253_abnormal_eye_physiology0.56725905
173MP0002693_abnormal_pancreas_physiology0.55638280

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)6.18401008
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.95240368
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.95240368
4Neurofibrillary tangles (HP:0002185)5.82737130
5Increased mean platelet volume (HP:0011877)5.79659285
6Prolonged bleeding time (HP:0003010)5.41593726
7Sensory axonal neuropathy (HP:0003390)5.23958298
8Abnormal platelet volume (HP:0011876)5.11382667
9Parakeratosis (HP:0001036)4.87020981
10Petechiae (HP:0000967)4.62138570
11Purpura (HP:0000979)4.56163359
12Prolonged partial thromboplastin time (HP:0003645)4.46727229
13Abnormality of the corticospinal tract (HP:0002492)4.37382932
14Hypoglycemic coma (HP:0001325)4.14964760
15Cerebral inclusion bodies (HP:0100314)4.13897566
16Hypobetalipoproteinemia (HP:0003563)3.72770465
17Peripheral hypomyelination (HP:0007182)3.68576828
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.62922568
19Xanthomatosis (HP:0000991)3.58961617
20Generalized aminoaciduria (HP:0002909)3.52398002
21Gingival bleeding (HP:0000225)3.50164717
22Increased serum pyruvate (HP:0003542)3.44126317
23Abnormality of glycolysis (HP:0004366)3.44126317
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44058105
25Onion bulb formation (HP:0003383)3.40610678
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35564371
27Abnormality of the common coagulation pathway (HP:0010990)3.30551284
28Joint hemorrhage (HP:0005261)3.30170437
29Abnormality of methionine metabolism (HP:0010901)3.29443725
30Epistaxis (HP:0000421)3.26829766
31Spastic gait (HP:0002064)3.19290593
32Hypoglycemic seizures (HP:0002173)3.09412208
33Supranuclear gaze palsy (HP:0000605)3.05593003
34Intention tremor (HP:0002080)3.03843978
35Leukodystrophy (HP:0002415)3.02462493
36Vascular calcification (HP:0004934)3.01565777
37Cerebral hemorrhage (HP:0001342)2.96786989
38Cerebral hypomyelination (HP:0006808)2.95054300
39Muscle fiber splitting (HP:0003555)2.90108665
40Acanthocytosis (HP:0001927)2.89764968
41Mitral stenosis (HP:0001718)2.89115710
42Complement deficiency (HP:0004431)2.86690074
43Spontaneous abortion (HP:0005268)2.84252012
44Abnormal auditory evoked potentials (HP:0006958)2.81782092
45Spastic paraparesis (HP:0002313)2.81765836
46Autoamputation (HP:0001218)2.81170574
47Dysmetria (HP:0001310)2.80529558
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77922587
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76891250
50Alacrima (HP:0000522)2.76795255
51Hyperglycinemia (HP:0002154)2.73050622
52Pancreatic islet-cell hyperplasia (HP:0004510)2.67603405
53Abnormal platelet function (HP:0011869)2.67463423
54Impaired platelet aggregation (HP:0003540)2.67463423
55Tongue fasciculations (HP:0001308)2.64726789
56Hyporeflexia of lower limbs (HP:0002600)2.64096489
57Conjugated hyperbilirubinemia (HP:0002908)2.63748737
58Pheochromocytoma (HP:0002666)2.63672834
59Akinesia (HP:0002304)2.62478166
60Congenital ichthyosiform erythroderma (HP:0007431)2.62388295
61Hyperinsulinemic hypoglycemia (HP:0000825)2.61541092
62Renal cortical cysts (HP:0000803)2.59005616
63Renal Fanconi syndrome (HP:0001994)2.57907743
64Insidious onset (HP:0003587)2.57313086
65Termporal pattern (HP:0011008)2.57313086
66Stridor (HP:0010307)2.56796662
67Cardiovascular calcification (HP:0011915)2.55571137
68Glycosuria (HP:0003076)2.53886300
69Abnormality of urine glucose concentration (HP:0011016)2.53886300
70Thickened helices (HP:0000391)2.53883970
71Poikilocytosis (HP:0004447)2.52218294
72Intrahepatic cholestasis (HP:0001406)2.51180057
73Infantile muscular hypotonia (HP:0008947)2.49674502
74Scanning speech (HP:0002168)2.49349090
75Arthropathy (HP:0003040)2.48446292
76Anteriorly placed anus (HP:0001545)2.46293096
77Methylmalonic acidemia (HP:0002912)2.46159567
78Abnormal pupillary function (HP:0007686)2.43937347
79Slow saccadic eye movements (HP:0000514)2.42806612
80Myokymia (HP:0002411)2.40317587
81Hypolipoproteinemia (HP:0010981)2.38076443
82Proximal tubulopathy (HP:0000114)2.38013119
83Neuroendocrine neoplasm (HP:0100634)2.33998162
84Acute necrotizing encephalopathy (HP:0006965)2.32744531
85Retinal dysplasia (HP:0007973)2.31966152
86Hyperglycemia (HP:0003074)2.31570597
87Dyschromatopsia (HP:0007641)2.27051028
88Abnormality of sulfur amino acid metabolism (HP:0004339)2.26451064
89Abnormality of serum amino acid levels (HP:0003112)2.25021256
90Muscle hypertrophy of the lower extremities (HP:0008968)2.22921434
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22391351
92Acute encephalopathy (HP:0006846)2.22125984
93Hypothermia (HP:0002045)2.21266884
94Hypoplastic pelvis (HP:0008839)2.21103156
95Abnormal sex determination (HP:0012244)2.20493931
96Sex reversal (HP:0012245)2.20493931
97Premature skin wrinkling (HP:0100678)2.19105520
98Abnormality of serine family amino acid metabolism (HP:0010894)2.18055141
99Abnormality of glycine metabolism (HP:0010895)2.18055141
100Muscle fibrillation (HP:0010546)2.17269659
1013-Methylglutaconic aciduria (HP:0003535)2.13191956
102Abnormality of the intrinsic pathway (HP:0010989)2.12166348
103Symptomatic seizures (HP:0011145)2.10346042
104Increased circulating renin level (HP:0000848)2.09159224
105Coronal craniosynostosis (HP:0004440)2.08681654
106Foot dorsiflexor weakness (HP:0009027)2.07727238
107Hyperlipoproteinemia (HP:0010980)2.07287168
108Glomerulonephritis (HP:0000099)2.06793534
109Abnormality of the renal cortex (HP:0011035)2.06577203
110Abnormality of alanine metabolism (HP:0010916)2.06447748
111Hyperalaninemia (HP:0003348)2.06447748
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06447748
113Abnormality of vitamin metabolism (HP:0100508)2.04331060
114Hepatosplenomegaly (HP:0001433)2.03961668
115Decreased lacrimation (HP:0000633)2.03467263
116Absent septum pellucidum (HP:0001331)2.03342498
117Decreased central vision (HP:0007663)2.01762608
118Mitochondrial inheritance (HP:0001427)1.98086204
119Testicular neoplasm (HP:0010788)1.97598183
120Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97117137
121Congenital malformation of the right heart (HP:0011723)1.96448454
122Double outlet right ventricle (HP:0001719)1.96448454
123Increased hepatocellular lipid droplets (HP:0006565)1.95222543
124Gowers sign (HP:0003391)1.93991914
125Spastic tetraparesis (HP:0001285)1.92926668
126Hypokalemic alkalosis (HP:0001949)1.92609086
127Hypoplasia of the iris (HP:0007676)1.91861632
128Ankle clonus (HP:0011448)1.91652937
129Adrenal hypoplasia (HP:0000835)1.91512048
130Delayed puberty (HP:0000823)1.91442181
131Hypophosphatemic rickets (HP:0004912)1.91271154
132Clumsiness (HP:0002312)1.90702956
133Abnormal mitochondria in muscle tissue (HP:0008316)1.89867690
134Progressive macrocephaly (HP:0004481)1.87853539
135Abnormality of the foot musculature (HP:0001436)1.87852137
136Hyperglycinuria (HP:0003108)1.87498785
137Lipid accumulation in hepatocytes (HP:0006561)1.86802013
138Papillary thyroid carcinoma (HP:0002895)1.86669862
139Partial agenesis of the corpus callosum (HP:0001338)1.86593055
140Synostosis involving the elbow (HP:0003938)1.85862966
141Humeroradial synostosis (HP:0003041)1.85862966
142Poor speech (HP:0002465)1.85461413
143Aplasia involving bones of the upper limbs (HP:0009823)1.85418074
144Aplasia of the phalanges of the hand (HP:0009802)1.85418074
145Aplasia involving bones of the extremities (HP:0009825)1.85418074
146Hypomagnesemia (HP:0002917)1.84808978
147Ileus (HP:0002595)1.84608097
148Hepatocellular necrosis (HP:0001404)1.84445438
149Paraparesis (HP:0002385)1.83921460
150Abnormality of complement system (HP:0005339)1.83916295
151Cerebral edema (HP:0002181)1.83493520
152Split foot (HP:0001839)1.83422661
153Metabolic alkalosis (HP:0200114)1.82801122
154Hepatic necrosis (HP:0002605)1.81475390
155Medial flaring of the eyebrow (HP:0010747)1.79185613
156Barrel-shaped chest (HP:0001552)1.78419352
157Patchy hypopigmentation of hair (HP:0011365)1.78319591
158Cupped ear (HP:0000378)1.77902613
159Male pseudohermaphroditism (HP:0000037)1.77581549
160Erythroderma (HP:0001019)1.76463381
161Nausea (HP:0002018)1.76207181
162CNS hypomyelination (HP:0003429)1.76122605
163Gout (HP:0001997)1.76090594
164Generalized myoclonic seizures (HP:0002123)1.76058339
165Deep venous thrombosis (HP:0002625)1.75214297
166Lower limb muscle weakness (HP:0007340)1.74855463
167Abnormality of endocrine pancreas physiology (HP:0012093)1.74681226
168Abnormality of the pancreatic islet cells (HP:0006476)1.74681226
169Segmental peripheral demyelination/remyelination (HP:0003481)1.74614969
170Axonal loss (HP:0003447)1.74101210
171White forelock (HP:0002211)1.73672259
172Morphological abnormality of the inner ear (HP:0011390)1.72356007
173Calf muscle hypertrophy (HP:0008981)1.72245364
174Azoospermia (HP:0000027)1.72139500
175Ketoacidosis (HP:0001993)1.71624324
176Renal salt wasting (HP:0000127)1.71342255
177Gonadal dysgenesis (HP:0000133)1.70946735
178Hypoalphalipoproteinemia (HP:0003233)1.70628847
179Megalencephaly (HP:0001355)1.69967007
180Intestinal atresia (HP:0011100)1.69337426
181Enlarged kidneys (HP:0000105)1.67485149
182Polyphagia (HP:0002591)1.67192393
183Abnormality of magnesium homeostasis (HP:0004921)1.66243829
184Abnormality of vitamin B metabolism (HP:0004340)1.66178424
185Abnormality of renal resorption (HP:0011038)1.65572959
186Ketosis (HP:0001946)1.64815076
187Rickets (HP:0002748)1.63871853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.58319278
2OXSR14.66764237
3FRK4.16188098
4EPHB13.09341667
5BCR2.98198694
6WNK42.96391494
7TRIM282.72504952
8MET2.64979218
9STK242.59988850
10PKN12.59286377
11CDK192.55129511
12PBK2.40633526
13LMTK22.40579427
14ICK2.23073867
15WNK12.20846367
16EIF2AK12.20089905
17LIMK12.14997808
18FGFR22.13591993
19CSNK1G31.90497335
20TNIK1.90050851
21CSNK1A1L1.89814267
22PRPF4B1.82829433
23NEK61.79998898
24FER1.77251160
25MST41.58301771
26PLK21.55196370
27MAPKAPK51.53810796
28CAMK2B1.53742638
29CSNK1G11.53309266
30MAPKAPK31.51837312
31ILK1.51074598
32CAMK2D1.50453726
33UHMK11.50052024
34NUAK11.49194806
35ROCK21.46456450
36PIK3CG1.43751641
37ACVR1B1.42799182
38NTRK11.37813028
39CSNK1G21.37719346
40ERBB31.34036092
41FGR1.32643038
42MKNK21.32503552
43MAP4K21.31890181
44TESK21.31246904
45PNCK1.31140237
46EPHA41.26039435
47ADRBK21.23651203
48PAK61.22190599
49TEC1.21715972
50STK31.18780245
51PLK31.18361991
52PAK31.14084467
53SIK31.10504008
54TRPM71.09890702
55CAMK2G1.09357450
56ERBB41.07424863
57CLK11.05844005
58BRSK21.04770623
59MAPK151.02434350
60STK38L1.01774213
61AKT31.00709540
62PHKG11.00555677
63PHKG21.00555677
64DAPK20.98977058
65SGK4940.94908017
66SGK2230.94908017
67MAP3K120.93878777
68GRK50.92632972
69BMPR20.91570972
70PRKCQ0.90786324
71MUSK0.90233629
72DYRK20.88933193
73NLK0.88849564
74ZAK0.87026204
75CAMK2A0.85937025
76BMPR1B0.84589436
77PRKCG0.80819163
78OBSCN0.79902915
79STK160.78378687
80PRKD10.77674047
81CDK140.77535602
82MARK10.75652692
83PIK3CA0.75446320
84MARK20.72659064
85SGK20.72480349
86CASK0.69657881
87CDK50.69513931
88PDPK10.68533096
89ARAF0.67901432
90PRKCE0.67132638
91FLT30.66792738
92TYRO30.65930630
93CDK150.63744576
94DAPK10.62656164
95IRAK20.60875917
96MAP3K20.59653079
97CDK180.57843260
98EPHA30.57314340
99MKNK10.56988918
100INSRR0.55517590
101PRKCH0.55506731
102CDK11A0.55498925
103GRK70.54469398
104BCKDK0.53741648
105YES10.53391505
106PRKACG0.52407246
107FYN0.50860609
108MAPK70.49341164
109FGFR10.48760925
110CAMKK20.48623420
111ADRBK10.48546359
112PRKG10.48408095
113CSNK1D0.48173955
114DDR20.48145166
115GSK3A0.45801568
116DYRK30.45620269
117ERBB20.45349051
118ITK0.44937618
119RPS6KA50.44779097
120PRKACB0.44699423
121NTRK30.43620091
122CSF1R0.42377437
123SGK30.39376481
124STK110.38840368
125PRKCI0.37673033
126PTK2B0.37428091
127PRKAA20.36980569
128MAP3K130.35778337
129PDGFRB0.35625822
130VRK10.35593238
131MINK10.35124489
132MAP2K20.34578275
133PRKG20.34398478
134CSNK1A10.33497638
135TNK20.33438797
136ROCK10.32857769
137MAPK130.32166581
138PINK10.31967990
139PRKCA0.30897581
140PRKACA0.30892415
141MYLK0.30825704
142PRKCB0.30169303
143PAK10.29243488
144KSR20.29137301
145INSR0.29102651
146TIE10.28929846
147DMPK0.27445325
148IRAK10.27302222
149PDK10.25534878
150GRK10.23494116
151CAMK1G0.22425653
152BMX0.21249719
153TTN0.21183077
154DAPK30.19747068
155CSNK1E0.19175524
156WNK30.18978943

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.56988579
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.34040132
3Steroid biosynthesis_Homo sapiens_hsa001004.10478600
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.58166690
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.87904086
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67835117
7Caffeine metabolism_Homo sapiens_hsa002322.66381329
8Ether lipid metabolism_Homo sapiens_hsa005652.51031825
9Oxidative phosphorylation_Homo sapiens_hsa001902.50329432
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47545574
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.26859049
12Sulfur metabolism_Homo sapiens_hsa009202.21463923
13Butanoate metabolism_Homo sapiens_hsa006502.09542141
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01090777
15Histidine metabolism_Homo sapiens_hsa003402.00425622
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96204265
17Protein export_Homo sapiens_hsa030601.89358247
18Parkinsons disease_Homo sapiens_hsa050121.88519595
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88200604
20Propanoate metabolism_Homo sapiens_hsa006401.79539523
21Vitamin B6 metabolism_Homo sapiens_hsa007501.79124797
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75265969
23Alzheimers disease_Homo sapiens_hsa050101.66718477
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59750778
25Fatty acid metabolism_Homo sapiens_hsa012121.57521874
26Arginine and proline metabolism_Homo sapiens_hsa003301.51971166
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50055047
28Linoleic acid metabolism_Homo sapiens_hsa005911.49632668
29Sphingolipid metabolism_Homo sapiens_hsa006001.49360780
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.48451805
31Starch and sucrose metabolism_Homo sapiens_hsa005001.43741083
32Axon guidance_Homo sapiens_hsa043601.42254784
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.40423734
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38062739
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37026000
36Nitrogen metabolism_Homo sapiens_hsa009101.30082323
37Cardiac muscle contraction_Homo sapiens_hsa042601.26958586
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23988190
39Peroxisome_Homo sapiens_hsa041461.22740347
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.20940544
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.19270876
42Fatty acid degradation_Homo sapiens_hsa000711.05522139
43Glutathione metabolism_Homo sapiens_hsa004801.04449379
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02349676
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01727262
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00081921
47Platelet activation_Homo sapiens_hsa046110.99662276
48Huntingtons disease_Homo sapiens_hsa050160.98187847
49Chemical carcinogenesis_Homo sapiens_hsa052040.94784822
50One carbon pool by folate_Homo sapiens_hsa006700.94474632
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92758406
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86780159
53Tight junction_Homo sapiens_hsa045300.81821004
54beta-Alanine metabolism_Homo sapiens_hsa004100.81359876
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80126536
56Tyrosine metabolism_Homo sapiens_hsa003500.79805852
57Pyruvate metabolism_Homo sapiens_hsa006200.79548312
58Folate biosynthesis_Homo sapiens_hsa007900.79381032
59Tryptophan metabolism_Homo sapiens_hsa003800.79107236
60Renal cell carcinoma_Homo sapiens_hsa052110.78285616
61Arachidonic acid metabolism_Homo sapiens_hsa005900.78159153
62Ovarian steroidogenesis_Homo sapiens_hsa049130.77247241
63Serotonergic synapse_Homo sapiens_hsa047260.75072784
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73672407
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73537806
66GABAergic synapse_Homo sapiens_hsa047270.72520894
67Retinol metabolism_Homo sapiens_hsa008300.71837229
68PPAR signaling pathway_Homo sapiens_hsa033200.69162647
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69007989
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67697783
71Pancreatic secretion_Homo sapiens_hsa049720.64423823
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63911031
73Selenocompound metabolism_Homo sapiens_hsa004500.62530202
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62508054
75Circadian rhythm_Homo sapiens_hsa047100.61501104
76Metabolic pathways_Homo sapiens_hsa011000.61419076
77Carbon metabolism_Homo sapiens_hsa012000.61129888
78Glutamatergic synapse_Homo sapiens_hsa047240.60790980
79Vibrio cholerae infection_Homo sapiens_hsa051100.59400674
80Fatty acid biosynthesis_Homo sapiens_hsa000610.56242182
81Complement and coagulation cascades_Homo sapiens_hsa046100.56008911
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.54624414
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54547001
84Autoimmune thyroid disease_Homo sapiens_hsa053200.53985404
85Biosynthesis of amino acids_Homo sapiens_hsa012300.53005134
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.52845986
87ECM-receptor interaction_Homo sapiens_hsa045120.51019940
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.49455717
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48863329
90Mismatch repair_Homo sapiens_hsa034300.47264818
91Morphine addiction_Homo sapiens_hsa050320.46647525
92Collecting duct acid secretion_Homo sapiens_hsa049660.46500274
93Long-term depression_Homo sapiens_hsa047300.43338973
94ABC transporters_Homo sapiens_hsa020100.42831912
95Endocytosis_Homo sapiens_hsa041440.42193313
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42170542
97Vitamin digestion and absorption_Homo sapiens_hsa049770.42142647
98Rheumatoid arthritis_Homo sapiens_hsa053230.41034886
99Malaria_Homo sapiens_hsa051440.40972637
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40485367
101Arginine biosynthesis_Homo sapiens_hsa002200.40433139
102Dilated cardiomyopathy_Homo sapiens_hsa054140.40369923
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39860594
104Ras signaling pathway_Homo sapiens_hsa040140.39850466
105Glycerolipid metabolism_Homo sapiens_hsa005610.39189273
106Phenylalanine metabolism_Homo sapiens_hsa003600.38592700
107Insulin secretion_Homo sapiens_hsa049110.38496196
108Dorso-ventral axis formation_Homo sapiens_hsa043200.38213591
109Glucagon signaling pathway_Homo sapiens_hsa049220.37812338
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36764433
111Galactose metabolism_Homo sapiens_hsa000520.36304900
112Lysosome_Homo sapiens_hsa041420.36170597
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.33576865
114Mineral absorption_Homo sapiens_hsa049780.33310546
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32330653
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32265568
117Fat digestion and absorption_Homo sapiens_hsa049750.32245824
118Cocaine addiction_Homo sapiens_hsa050300.31673798
119Bile secretion_Homo sapiens_hsa049760.31267356
120Basal transcription factors_Homo sapiens_hsa030220.27926877
121Hedgehog signaling pathway_Homo sapiens_hsa043400.26410285
122Circadian entrainment_Homo sapiens_hsa047130.26080046
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25982289
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25326706
125Regulation of autophagy_Homo sapiens_hsa041400.25279863
126ErbB signaling pathway_Homo sapiens_hsa040120.24778294
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24607754
128Phagosome_Homo sapiens_hsa041450.23491661
129Phototransduction_Homo sapiens_hsa047440.22845855
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22189329
131Pentose phosphate pathway_Homo sapiens_hsa000300.21585492
132Thyroid hormone synthesis_Homo sapiens_hsa049180.20741811
133Proteasome_Homo sapiens_hsa030500.18766699
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15389439
135Purine metabolism_Homo sapiens_hsa002300.14812811

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