GRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88853081
2negative regulation of cell killing (GO:0031342)4.88853081
3antigen processing and presentation of endogenous antigen (GO:0019883)4.60179756
4regulation of B cell receptor signaling pathway (GO:0050855)4.50327301
5detection of other organism (GO:0098543)4.36336936
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25084417
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.25084417
8B cell receptor signaling pathway (GO:0050853)4.15983435
9detection of bacterium (GO:0016045)4.15749263
10positive regulation of gamma-delta T cell activation (GO:0046645)4.10307899
11Arp2/3 complex-mediated actin nucleation (GO:0034314)4.09213079
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.03555785
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.03555785
14modulation by symbiont of host immune response (GO:0052553)4.03555785
15positive regulation by symbiont of host defense response (GO:0052509)4.03555785
16modulation by symbiont of host defense response (GO:0052031)4.03555785
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.03555785
18regulation of mast cell degranulation (GO:0043304)3.75155200
19detection of external biotic stimulus (GO:0098581)3.65824350
20protein localization to endosome (GO:0036010)3.56804633
21regulation of interferon-beta biosynthetic process (GO:0045357)3.53519738
22immunoglobulin mediated immune response (GO:0016064)3.53147864
23detection of molecule of bacterial origin (GO:0032490)3.50538606
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.41882750
25regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40890002
26regulation of mast cell activation involved in immune response (GO:0033006)3.39760177
27synaptic vesicle maturation (GO:0016188)3.39477832
28response to muramyl dipeptide (GO:0032495)3.39477594
29respiratory burst (GO:0045730)3.38016127
30macrophage activation involved in immune response (GO:0002281)3.37749231
31positive regulation of lamellipodium assembly (GO:0010592)3.28808016
32cellular response to type I interferon (GO:0071357)3.27706347
33type I interferon signaling pathway (GO:0060337)3.27706347
34negative regulation of leukocyte mediated immunity (GO:0002704)3.25143398
35positive regulation of B cell differentiation (GO:0045579)3.24240620
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23574378
37regulation of mast cell activation (GO:0033003)3.22678985
38response to type I interferon (GO:0034340)3.22550722
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21252268
40microglial cell activation (GO:0001774)3.21035009
41NIK/NF-kappaB signaling (GO:0038061)3.19339717
42macrophage activation (GO:0042116)3.19119913
43cellular response to zinc ion (GO:0071294)3.18259208
44response to interleukin-15 (GO:0070672)3.17351417
45regulation of ARF GTPase activity (GO:0032312)3.17297862
46negative regulation of T cell mediated immunity (GO:0002710)3.16996561
47detection of biotic stimulus (GO:0009595)3.16946391
48germinal center formation (GO:0002467)3.16788899
49cellular response to nerve growth factor stimulus (GO:1990090)3.12748034
50response to nerve growth factor (GO:1990089)3.12748034
51regulation of gamma-delta T cell differentiation (GO:0045586)3.11802024
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11042682
53positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10112340
54T-helper 1 type immune response (GO:0042088)3.09718014
55* Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.05101729
56production of molecular mediator involved in inflammatory response (GO:0002532)3.04456459
57G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03267209
58regulation of ARF protein signal transduction (GO:0032012)3.02265346
59regulation of B cell differentiation (GO:0045577)3.01967599
60actin nucleation (GO:0045010)3.01490488
61* Fc-gamma receptor signaling pathway (GO:0038094)3.01406892
62* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.01406892
63* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.01406892
64regulation of T cell tolerance induction (GO:0002664)2.99415729
65neutrophil activation involved in immune response (GO:0002283)2.98653264
66regulation of antigen processing and presentation (GO:0002577)2.97082464
67positive regulation of cellular amide metabolic process (GO:0034250)2.96747837
68regulation of regulated secretory pathway (GO:1903305)2.96528257
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93407075
70positive thymic T cell selection (GO:0045059)2.93213522
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92231898
72T cell migration (GO:0072678)2.89124287
73positive regulation of Rap GTPase activity (GO:0032854)2.87607051
74negative regulation of phagocytosis (GO:0050765)2.86882454
75cortical actin cytoskeleton organization (GO:0030866)2.86796257
76clathrin coat assembly (GO:0048268)2.86449876
77cellular response to interleukin-15 (GO:0071350)2.85969423
78mature B cell differentiation (GO:0002335)2.85348590
79JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83757419
80leukocyte degranulation (GO:0043299)2.82325295
81locomotory exploration behavior (GO:0035641)2.82191169
82positive regulation of lamellipodium organization (GO:1902745)2.81503112
83interferon-gamma-mediated signaling pathway (GO:0060333)2.81236303
84regulation of tolerance induction (GO:0002643)2.81171393
85antigen processing and presentation via MHC class Ib (GO:0002475)2.81004269
86regulation of gamma-delta T cell activation (GO:0046643)2.80907170
87negative regulation of cytokine production involved in immune response (GO:0002719)2.80630399
88positive regulation of mast cell activation (GO:0033005)2.79948571
89positive regulation of type 2 immune response (GO:0002830)2.78302703
90negative regulation of innate immune response (GO:0045824)2.78140667
91positive regulation of histone deacetylation (GO:0031065)2.77914333
92N-acetylneuraminate metabolic process (GO:0006054)2.77623763
93tolerance induction (GO:0002507)2.75200858
94positive regulation of antigen processing and presentation (GO:0002579)2.74233349
95positive regulation of leukocyte degranulation (GO:0043302)2.74008753
96regulation of T-helper 2 cell differentiation (GO:0045628)2.73391563
97myeloid cell activation involved in immune response (GO:0002275)2.72425138
98T cell selection (GO:0045058)2.72174757
99negative thymic T cell selection (GO:0045060)2.71724110
100leukocyte aggregation (GO:0070486)2.71620552
101myeloid dendritic cell differentiation (GO:0043011)2.70229120
102negative regulation of erythrocyte differentiation (GO:0045647)2.69349924
103nerve growth factor signaling pathway (GO:0038180)2.68708202
104positive regulation of macrophage cytokine production (GO:0060907)2.67038882
105response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66851100
106response to host immune response (GO:0052572)2.66851100
107natural killer cell differentiation (GO:0001779)2.65516999
108response to peptidoglycan (GO:0032494)2.65442739
109positive regulation of mast cell degranulation (GO:0043306)2.65363122
110positive regulation of mast cell activation involved in immune response (GO:0033008)2.65363122
111negative regulation of interleukin-6 production (GO:0032715)2.64527253
112B cell mediated immunity (GO:0019724)2.64338323
113defense response to protozoan (GO:0042832)2.63429024
114thymic T cell selection (GO:0045061)2.62462794
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.61947180
116barbed-end actin filament capping (GO:0051016)2.60926774
117positive regulation of interferon-alpha production (GO:0032727)2.59672845
118negative regulation of interleukin-12 production (GO:0032695)2.59329463
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58056973
120granulocyte activation (GO:0036230)2.56954387
121regulation of macrophage cytokine production (GO:0010935)2.56842154
122cellular extravasation (GO:0045123)2.56351516
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55294192
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53706620
125actin filament polymerization (GO:0030041)2.53481957
126myeloid dendritic cell activation (GO:0001773)2.52815925
127neutrophil activation (GO:0042119)2.52525659
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51398242
129negative T cell selection (GO:0043383)2.51260740
130regulation of early endosome to late endosome transport (GO:2000641)2.50926917
131regulation of interferon-alpha production (GO:0032647)2.50622432
132* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.50331974
133sodium ion export (GO:0071436)2.50073788
134regulation of erythrocyte differentiation (GO:0045646)2.49163978
135regulation of Rap GTPase activity (GO:0032317)2.49076534
136response to host (GO:0075136)2.48108447
137response to host defenses (GO:0052200)2.48108447
138response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48108447
139regulation of leukocyte degranulation (GO:0043300)2.47687212
140response to protozoan (GO:0001562)2.46203789
141positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45924942
142positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.44148681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.69738576
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.42972182
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26080718
4VDR_21846776_ChIP-Seq_THP-1_Human3.22933473
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.17203766
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05468508
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01923780
8* EGR1_19374776_ChIP-ChIP_THP-1_Human2.87279831
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.85404955
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.84894083
11* KDM2B_26808549_Chip-Seq_DND41_Human2.82421501
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70511256
13TCF7_22412390_ChIP-Seq_EML_Mouse2.68760243
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.66203579
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54220346
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51090897
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42069873
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.41034060
19* MAF_26560356_Chip-Seq_TH1_Human2.36289708
20VDR_24763502_ChIP-Seq_THP-1_Human2.30655814
21* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27241084
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25038281
23* SPI1_23127762_ChIP-Seq_K562_Human2.20159121
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.17433976
25SCL_19346495_ChIP-Seq_HPC-7_Human2.13944749
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10756797
27LXR_22292898_ChIP-Seq_THP-1_Human2.07801325
28UTX_26944678_Chip-Seq_JUKART_Human2.07665752
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02928927
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01427522
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98116613
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.96789258
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94301184
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90091415
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87605608
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82968718
37* MYB_26560356_Chip-Seq_TH2_Human1.81501282
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77230299
39* KDM2B_26808549_Chip-Seq_JURKAT_Human1.75865042
40RUNX_20019798_ChIP-Seq_JUKART_Human1.70288130
41* SPI1_23547873_ChIP-Seq_NB4_Human1.69962976
42* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67574810
43* KDM2B_26808549_Chip-Seq_K562_Human1.67510370
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67057780
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65460539
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64196964
47MYB_26560356_Chip-Seq_TH1_Human1.62921302
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62750847
49MAF_26560356_Chip-Seq_TH2_Human1.60692009
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57507496
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56588977
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56358802
53* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50911550
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50750678
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47364751
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47253756
57VDR_24787735_ChIP-Seq_THP-1_Human1.46813628
58* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45848517
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44415005
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42659318
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39251950
62* GATA1_19941827_ChIP-Seq_MEL_Mouse1.38951707
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37797741
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37155476
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36921620
66RACK7_27058665_Chip-Seq_MCF-7_Human1.36537001
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36344429
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34145926
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32953215
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.32063163
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31833807
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30248503
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28474736
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27916589
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27866991
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27745635
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27637276
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25646422
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25509529
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25114647
81TFEB_21752829_ChIP-Seq_HELA_Human1.22292496
82* NCOR1_26117541_ChIP-Seq_K562_Human1.21570607
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18274583
84* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17298572
85GATA1_19941826_ChIP-Seq_K562_Human1.15072255
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15055681
87CIITA_25753668_ChIP-Seq_RAJI_Human1.14320588
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13893171
89BCOR_27268052_Chip-Seq_Bcells_Human1.12622867
90* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11971457
91GATA3_27048872_Chip-Seq_THYMUS_Human1.11843581
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11815076
93* PU_27001747_Chip-Seq_BMDM_Mouse1.11660242
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11424388
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09697059
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09456119
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.08501738
98* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08295800
99SPI1_20517297_ChIP-Seq_HL60_Human1.03700266
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.03534264
101ZNF263_19887448_ChIP-Seq_K562_Human1.03496173
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03456566
103* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03297632
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02850148
105* BCL6_27268052_Chip-Seq_Bcells_Human1.00638992
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99638344
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98454434
108* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98397205
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.98146479
110P68_20966046_ChIP-Seq_HELA_Human0.97726392
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97655415
112* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96596676
113* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96578371
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95441736
115CREB1_26743006_Chip-Seq_LNCaP_Human0.94733023
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92427573
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91680106
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91476283
119GATA3_26560356_Chip-Seq_TH2_Human0.90087613
120GATA1_22025678_ChIP-Seq_K562_Human0.88208364
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83624494
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82313981
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80802625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.39931242
2MP0001835_abnormal_antigen_presentation3.47661759
3MP0003724_increased_susceptibility_to3.47596902
4MP0004510_myositis3.19039915
5MP0004859_abnormal_synaptic_plasticity3.02246733
6MP0005387_immune_system_phenotype2.73650507
7MP0001790_abnormal_immune_system2.73650507
8MP0001800_abnormal_humoral_immune2.63665622
9MP0003436_decreased_susceptibility_to2.56300263
10MP0005058_abnormal_lysosome_morphology2.53259011
11MP0000685_abnormal_immune_system2.52064886
12MP0005000_abnormal_immune_tolerance2.49272265
13MP0003172_abnormal_lysosome_physiology2.47975407
14MP0002452_abnormal_antigen_presenting2.40556773
15MP0003300_gastrointestinal_ulcer2.33112907
16MP0006082_CNS_inflammation2.24772878
17MP0005671_abnormal_response_to2.21469066
18MP0002723_abnormal_immune_serum2.16005794
19MP0002419_abnormal_innate_immunity2.14919333
20MP0002420_abnormal_adaptive_immunity2.12144904
21MP0001819_abnormal_immune_cell2.11374801
22MP0008260_abnormal_autophagy2.07616956
23* MP0005025_abnormal_response_to2.00713276
24MP0009278_abnormal_bone_marrow2.00691273
25MP0005464_abnormal_platelet_physiology1.95408408
26* MP0002398_abnormal_bone_marrow1.90224691
27MP0002148_abnormal_hypersensitivity_rea1.87256167
28MP0005451_abnormal_body_composition1.81483478
29* MP0000716_abnormal_immune_system1.75299974
30MP0003075_altered_response_to1.72861963
31MP0009785_altered_susceptibility_to1.70873626
32MP0004858_abnormal_nervous_system1.68726301
33MP0005076_abnormal_cell_differentiation1.66438089
34MP0002405_respiratory_system_inflammati1.57020727
35MP0000689_abnormal_spleen_morphology1.54806076
36MP0000604_amyloidosis1.54710927
37MP0005310_abnormal_salivary_gland1.49329396
38MP0002722_abnormal_immune_system1.44873757
39MP0008961_abnormal_basal_metabolism1.44510086
40* MP0002429_abnormal_blood_cell1.43089109
41MP0010155_abnormal_intestine_physiology1.42186131
42MP0001845_abnormal_inflammatory_respons1.40242056
43MP0000465_gastrointestinal_hemorrhage1.38978286
44MP0005174_abnormal_tail_pigmentation1.35422686
45MP0009333_abnormal_splenocyte_physiolog1.35327677
46MP0000569_abnormal_digit_pigmentation1.34898437
47MP0005397_hematopoietic_system_phenotyp1.34388675
48MP0001545_abnormal_hematopoietic_system1.34388675
49MP0009840_abnormal_foam_cell1.33772086
50MP0009764_decreased_sensitivity_to1.33096693
51MP0004947_skin_inflammation1.33055298
52MP0003635_abnormal_synaptic_transmissio1.30321182
53MP0002396_abnormal_hematopoietic_system1.28476470
54MP0003448_altered_tumor_morphology1.28192749
55MP0003183_abnormal_peptide_metabolism1.28075776
56MP0003329_amyloid_beta_deposits1.27454467
57MP0003690_abnormal_glial_cell1.19609304
58MP0005166_decreased_susceptibility_to1.19480887
59MP0010352_gastrointestinal_tract_polyps1.19196266
60MP0003191_abnormal_cellular_cholesterol1.17940153
61MP0003866_abnormal_defecation1.17697019
62MP0001533_abnormal_skeleton_physiology1.17556828
63MP0004808_abnormal_hematopoietic_stem1.13096502
64MP0001873_stomach_inflammation1.12098962
65MP0004381_abnormal_hair_follicle1.11875664
66MP0003221_abnormal_cardiomyocyte_apopto1.11056537
67MP0001348_abnormal_lacrimal_gland1.10006411
68MP0004130_abnormal_muscle_cell1.06070405
69MP0002132_abnormal_respiratory_system1.05528957
70MP0001853_heart_inflammation1.05417549
71MP0003763_abnormal_thymus_physiology1.04912369
72MP0002064_seizures1.04280569
73* MP0000703_abnormal_thymus_morphology1.02690354
74MP0002909_abnormal_adrenal_gland1.02143226
75MP0004883_abnormal_blood_vessel1.01605471
76MP0000343_altered_response_to0.98119723
77MP0003566_abnormal_cell_adhesion0.97533694
78MP0002166_altered_tumor_susceptibility0.96472549
79MP0002733_abnormal_thermal_nociception0.96284794
80MP0003705_abnormal_hypodermis_morpholog0.96167040
81MP0002063_abnormal_learning/memory/cond0.96105653
82MP0000858_altered_metastatic_potential0.95788153
83MP0008874_decreased_physiological_sensi0.95651108
84MP0000920_abnormal_myelination0.95239483
85MP0008469_abnormal_protein_level0.91739305
86MP0004811_abnormal_neuron_physiology0.91573564
87MP0008569_lethality_at_weaning0.91267391
88MP0005167_abnormal_blood-brain_barrier0.90862756
89MP0000015_abnormal_ear_pigmentation0.89654218
90MP0002138_abnormal_hepatobiliary_system0.89464151
91MP0003806_abnormal_nucleotide_metabolis0.88478086
92MP0000490_abnormal_crypts_of0.86384417
93MP0004185_abnormal_adipocyte_glucose0.85877737
94MP0001851_eye_inflammation0.85229148
95MP0009763_increased_sensitivity_to0.84103116
96MP0003091_abnormal_cell_migration0.84083811
97MP0002877_abnormal_melanocyte_morpholog0.83848894
98MP0002277_abnormal_respiratory_mucosa0.83388178
99MP0002998_abnormal_bone_remodeling0.81525108
100MP0010307_abnormal_tumor_latency0.80059042
101MP0004270_analgesia0.79590431
102MP0001970_abnormal_pain_threshold0.78352298
103MP0003828_pulmonary_edema0.75687045
104MP0005075_abnormal_melanosome_morpholog0.75599397
105MP0003656_abnormal_erythrocyte_physiolo0.74307710
106MP0003633_abnormal_nervous_system0.73864484
107MP0009046_muscle_twitch0.73735836
108MP0001663_abnormal_digestive_system0.73734769
109MP0005164_abnormal_response_to0.73370381
110MP0002006_tumorigenesis0.71623380
111MP0002735_abnormal_chemical_nociception0.71407512
112MP0005390_skeleton_phenotype0.69899278
113MP0009745_abnormal_behavioral_response0.69139691
114MP0003795_abnormal_bone_structure0.68251264
115MP0003045_fibrosis0.66348063
116MP0008004_abnormal_stomach_pH0.65328676
117MP0009765_abnormal_xenobiotic_induced0.64395097
118MP0000609_abnormal_liver_physiology0.63585588
119MP0003634_abnormal_glial_cell0.62834142
120MP0003453_abnormal_keratinocyte_physiol0.61110329
121MP0000371_diluted_coat_color0.60345471
122MP0000249_abnormal_blood_vessel0.57113536
123MP0002693_abnormal_pancreas_physiology0.55606311
124MP0005584_abnormal_enzyme/coenzyme_acti0.55311200
125MP0002254_reproductive_system_inflammat0.54868882
126MP0002933_joint_inflammation0.52465330

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.46227993
2Eczematoid dermatitis (HP:0000976)4.33796128
3Orchitis (HP:0100796)4.14141121
4Recurrent bacterial skin infections (HP:0005406)4.03919878
5Cellulitis (HP:0100658)3.97751171
6Optic neuritis (HP:0100653)3.95202432
7Retrobulbar optic neuritis (HP:0100654)3.95202432
8Increased cerebral lipofuscin (HP:0011813)3.85712033
9Mutism (HP:0002300)3.46395281
10Chronic otitis media (HP:0000389)3.35453180
11Papilledema (HP:0001085)3.33651459
12Disinhibition (HP:0000734)3.30708812
13Recurrent fungal infections (HP:0002841)3.26661657
14Recurrent gram-negative bacterial infections (HP:0005420)3.23116998
15Supranuclear gaze palsy (HP:0000605)3.22683695
16Chronic obstructive pulmonary disease (HP:0006510)3.18232162
17Obstructive lung disease (HP:0006536)3.18232162
18Gastrointestinal infarctions (HP:0005244)3.12972986
19Apathy (HP:0000741)3.10594372
20Recurrent viral infections (HP:0004429)3.08797479
21Diminished motivation (HP:0000745)3.02108274
22Encephalitis (HP:0002383)3.01007813
23Colitis (HP:0002583)2.98610096
24Mediastinal lymphadenopathy (HP:0100721)2.97135891
25Abnormality of macrophages (HP:0004311)2.96690563
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.96234347
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95110157
28Pulmonary infiltrates (HP:0002113)2.93165310
29Gastrointestinal inflammation (HP:0004386)2.89848657
30Agammaglobulinemia (HP:0004432)2.88358258
31Inflammation of the large intestine (HP:0002037)2.87531041
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.79515677
33Dysostosis multiplex (HP:0000943)2.76558220
34Recurrent skin infections (HP:0001581)2.75935285
35Verrucae (HP:0200043)2.72772406
36Papilloma (HP:0012740)2.72772406
37Pustule (HP:0200039)2.72446340
38Hemoptysis (HP:0002105)2.68058791
39Abnormality of glycolipid metabolism (HP:0010969)2.66748888
40Abnormality of liposaccharide metabolism (HP:0010968)2.66748888
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.66748888
42Keratoconjunctivitis sicca (HP:0001097)2.65099153
43Meningitis (HP:0001287)2.60846801
44Visual hallucinations (HP:0002367)2.56389609
45Purpura (HP:0000979)2.55868077
46Amyloidosis (HP:0011034)2.55697723
47T lymphocytopenia (HP:0005403)2.54598074
48Interstitial pulmonary disease (HP:0006530)2.54210553
49Neuronal loss in central nervous system (HP:0002529)2.50542806
50Keratoconjunctivitis (HP:0001096)2.49080349
51Gastrointestinal stroma tumor (HP:0100723)2.47962862
52Inappropriate behavior (HP:0000719)2.47043705
53Recurrent cutaneous fungal infections (HP:0011370)2.43072071
54Chronic mucocutaneous candidiasis (HP:0002728)2.43072071
55Loss of speech (HP:0002371)2.42396330
56Arterial thrombosis (HP:0004420)2.41018025
57Epistaxis (HP:0000421)2.39990158
58Hyperacusis (HP:0010780)2.39111151
59Elevated erythrocyte sedimentation rate (HP:0003565)2.38478775
60Abnormality of T cell number (HP:0011839)2.37706872
61Nasal polyposis (HP:0100582)2.37701236
62Increased IgM level (HP:0003496)2.36473751
63Diplopia (HP:0000651)2.34053711
64Abnormality of binocular vision (HP:0011514)2.34053711
65Spontaneous hematomas (HP:0007420)2.33813336
66Episodic fever (HP:0001954)2.33740153
67IgM deficiency (HP:0002850)2.33482907
68Lymphopenia (HP:0001888)2.32268040
69Hepatosplenomegaly (HP:0001433)2.31793396
70Gingival bleeding (HP:0000225)2.31775925
71Amyotrophic lateral sclerosis (HP:0007354)2.31383451
72Recurrent bronchitis (HP:0002837)2.30551896
73Increased serum ferritin (HP:0003281)2.30512717
74Pulmonary embolism (HP:0002204)2.27830434
75Leukocytosis (HP:0001974)2.27406829
76Axonal loss (HP:0003447)2.24309649
77Chest pain (HP:0100749)2.23628349
78Abnormality of the nasal mucosa (HP:0000433)2.21986291
79Vasculitis (HP:0002633)2.21761444
80Abnormality of T cells (HP:0002843)2.21101552
81Urinary glycosaminoglycan excretion (HP:0003541)2.20648184
82Mucopolysacchariduria (HP:0008155)2.20648184
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.19650906
84Achilles tendon contracture (HP:0001771)2.18254538
85Myokymia (HP:0002411)2.17796733
86Myositis (HP:0100614)2.15568888
87Autoimmune thrombocytopenia (HP:0001973)2.14655908
88Cerebral inclusion bodies (HP:0100314)2.11989772
89Vacuolated lymphocytes (HP:0001922)2.09300947
90Gingivitis (HP:0000230)2.08524651
91Hypertensive crisis (HP:0100735)2.07607562
92Stomatitis (HP:0010280)2.06435736
93Emphysema (HP:0002097)2.05467181
94Panhypogammaglobulinemia (HP:0003139)2.04854466
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03343651
96Increased IgE level (HP:0003212)2.03155195
97Anorexia (HP:0002039)2.03008511
98Hypergammaglobulinemia (HP:0010702)2.02136979
99Restrictive lung disease (HP:0002091)2.00893789
100Petechiae (HP:0000967)2.00422240
101Macroorchidism (HP:0000053)1.99784177
102Glomerulopathy (HP:0100820)1.99200024
103Granulocytopenia (HP:0001913)1.98914653
104Premature loss of primary teeth (HP:0006323)1.98097172
105Osteomyelitis (HP:0002754)1.97794751
106Polyneuropathy (HP:0001271)1.96751036
107Systemic lupus erythematosus (HP:0002725)1.95814768
108Abnormality of polysaccharide metabolism (HP:0011012)1.95192214
109Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95192214
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95192214
111Urticaria (HP:0001025)1.94872350
112Slow saccadic eye movements (HP:0000514)1.94165289
113Rapidly progressive (HP:0003678)1.93979756
114Progressive neurologic deterioration (HP:0002344)1.93457464
115Neurofibrillary tangles (HP:0002185)1.92192514
116Hematochezia (HP:0002573)1.91359328
117Abnormality of iron homeostasis (HP:0011031)1.91295159
118Abnormality of the pleura (HP:0002103)1.91266741
119Viral hepatitis (HP:0006562)1.89656783
120Abnormality of the Achilles tendon (HP:0005109)1.89343796
121Cerebral aneurysm (HP:0004944)1.87578763
122Gangrene (HP:0100758)1.86052132
123Annular pancreas (HP:0001734)1.85649478
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84277328
125Akinesia (HP:0002304)1.79377007
126Abnormality of the lower motor neuron (HP:0002366)1.76627439
127Prolonged bleeding time (HP:0003010)1.76291691
128Increased density of long bones (HP:0006392)1.75775393
129Sepsis (HP:0100806)1.75178376
130Asymmetric septal hypertrophy (HP:0001670)1.74652769
131Hypercortisolism (HP:0001578)1.74302949
132Frequent falls (HP:0002359)1.74056079
133Fatigue (HP:0012378)1.73571258
134Abnormality of T cell physiology (HP:0011840)1.73556427
135Impaired platelet aggregation (HP:0003540)1.70165727
136Abnormal platelet function (HP:0011869)1.70165727
137Pointed chin (HP:0000307)1.70052912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.70110433
2MAP4K13.54346528
3PRPF4B3.04838996
4MAP3K92.97410458
5RIPK42.89721852
6PKN22.58805220
7BLK2.47103069
8ERN12.20861383
9GRK62.19798899
10FES2.10294933
11SIK21.98686714
12MAP3K101.96131549
13SIK31.95596766
14SCYL21.95521129
15EEF2K1.89680628
16CSF1R1.74944015
17KSR21.74818333
18TYK21.67172436
19MARK11.64726053
20IRAK31.64236664
21SYK1.61210422
22TBK11.61126169
23LRRK21.57816123
24TXK1.55283479
25MAP3K31.52501820
26KIT1.52359486
27MATK1.51347200
28CAMKK11.49938841
29* ALK1.49854963
30EPHB11.49196175
31BMX1.47039746
32TAOK11.43959822
33STK101.39109564
34FGR1.38305129
35CSK1.33167829
36HCK1.32858477
37SMG11.28097688
38PAK61.24061198
39MAP3K131.19579173
40TAOK21.18075827
41JAK11.15849266
42TESK21.13941559
43PTK61.11414108
44BTK1.09186195
45NME21.07107178
46BMPR21.06770009
47ZAP701.05060801
48MINK11.02593193
49TYRO31.01822641
50PRKCH0.98634308
51RET0.96138589
52MAP3K110.93138728
53JAK30.91042598
54SIK10.90714987
55RIPK10.87021159
56IRAK40.84904078
57TGFBR20.83682226
58PDK10.83579227
59CDK120.83166416
60CDC42BPA0.80725613
61PIM20.80554182
62ICK0.79943574
63LCK0.78117926
64MAP2K30.76937195
65STK110.75818095
66MAP3K140.73875083
67DAPK20.72666130
68IRAK20.71963337
69TNK20.71273164
70LYN0.71064513
71CLK10.70893600
72DMPK0.70706959
73YES10.70482416
74MAP3K10.65880342
75ITK0.65385523
76* JAK20.65050441
77HIPK20.64467036
78MAP2K40.64243005
79FYN0.63388458
80MAP3K60.63297075
81UHMK10.61319739
82PDPK10.61177689
83NTRK10.60516540
84IKBKB0.58991904
85PRKD20.58934749
86CDK190.58682568
87TAOK30.58479818
88FGFR30.58266628
89CDK50.58066505
90IRAK10.57955120
91PRKCQ0.55818011
92DAPK10.55694746
93ARAF0.54978486
94PHKG20.54435235
95PHKG10.54435235
96RAF10.53684071
97GRK70.53006489
98MAP2K20.52263272
99GRK50.51720142
100MAPK40.51687999
101TEC0.50081955
102PIM10.47100429
103CHUK0.46870783
104CDK40.46389455
105CAMK1G0.46385607
106MARK20.46364050
107TTN0.45935676
108KSR10.45430667
109CDK60.44505626
110* EGFR0.44200824
111LIMK10.43983686
112MARK30.43658693
113MAP3K50.43587043
114MAPK70.43120360
115MAPKAPK20.43033612
116IKBKE0.43030620
117CDK140.42966822
118RPS6KA20.42950581
119CDK150.42892702
120PRKD10.42817058
121CAMKK20.42594002
122MAPK110.41897088
123CDK11A0.41270166
124MAPK120.39929119
125RPS6KC10.39691041
126RPS6KL10.39691041
127MAP3K80.39099159
128MAP2K60.38482285
129NTRK20.38280975
130TESK10.36957956
131FGFR40.36843178
132NTRK30.35696839
133SGK30.30672254
134DYRK1B0.30450682

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.78177543
2* B cell receptor signaling pathway_Homo sapiens_hsa046622.77608836
3Graft-versus-host disease_Homo sapiens_hsa053322.62327581
4Autoimmune thyroid disease_Homo sapiens_hsa053202.53728047
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.49556874
6Leishmaniasis_Homo sapiens_hsa051402.17883906
7Type I diabetes mellitus_Homo sapiens_hsa049402.13839206
8* Osteoclast differentiation_Homo sapiens_hsa043802.11372348
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99490362
10* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98126037
11Tuberculosis_Homo sapiens_hsa051521.70263017
12Rheumatoid arthritis_Homo sapiens_hsa053231.68940271
13Primary immunodeficiency_Homo sapiens_hsa053401.68923670
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66467191
15* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59654052
16VEGF signaling pathway_Homo sapiens_hsa043701.58575521
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56212329
18* Neurotrophin signaling pathway_Homo sapiens_hsa047221.55492293
19* Chemokine signaling pathway_Homo sapiens_hsa040621.55341839
20Shigellosis_Homo sapiens_hsa051311.54961651
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54703957
22Lysosome_Homo sapiens_hsa041421.43556420
23Antigen processing and presentation_Homo sapiens_hsa046121.40298967
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39335021
25Pertussis_Homo sapiens_hsa051331.37018606
26Salmonella infection_Homo sapiens_hsa051321.33985971
27* Chronic myeloid leukemia_Homo sapiens_hsa052201.30895162
28* T cell receptor signaling pathway_Homo sapiens_hsa046601.30127195
29Platelet activation_Homo sapiens_hsa046111.28668807
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28003579
31Toxoplasmosis_Homo sapiens_hsa051451.26695313
32* Acute myeloid leukemia_Homo sapiens_hsa052211.26254373
33Long-term potentiation_Homo sapiens_hsa047201.22526866
34Endocytosis_Homo sapiens_hsa041441.21884996
35mTOR signaling pathway_Homo sapiens_hsa041501.21128930
36Pancreatic cancer_Homo sapiens_hsa052121.16542288
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.15460109
38Apoptosis_Homo sapiens_hsa042101.13832582
39Viral myocarditis_Homo sapiens_hsa054161.11958731
40Synaptic vesicle cycle_Homo sapiens_hsa047211.11145893
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.10689866
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.10424399
43Measles_Homo sapiens_hsa051621.09579546
44Staphylococcus aureus infection_Homo sapiens_hsa051501.09360561
45Colorectal cancer_Homo sapiens_hsa052101.08724789
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07442826
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.04901608
48* Non-small cell lung cancer_Homo sapiens_hsa052231.03379122
49* Glioma_Homo sapiens_hsa052141.03186342
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.01771677
51* Hepatitis C_Homo sapiens_hsa051601.00598386
52* Renal cell carcinoma_Homo sapiens_hsa052111.00419456
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99634262
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98329558
55TNF signaling pathway_Homo sapiens_hsa046680.96355791
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95169121
57Type II diabetes mellitus_Homo sapiens_hsa049300.93329001
58* Hepatitis B_Homo sapiens_hsa051610.93207940
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93204320
60* Phospholipase D signaling pathway_Homo sapiens_hsa040720.91291482
61* Estrogen signaling pathway_Homo sapiens_hsa049150.90418927
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90326252
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90280560
64Influenza A_Homo sapiens_hsa051640.89601266
65Hematopoietic cell lineage_Homo sapiens_hsa046400.88978966
66Long-term depression_Homo sapiens_hsa047300.88805398
67Olfactory transduction_Homo sapiens_hsa047400.85750555
68* MAPK signaling pathway_Homo sapiens_hsa040100.85007263
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84299560
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84206624
71Phagosome_Homo sapiens_hsa041450.84173922
72Cholinergic synapse_Homo sapiens_hsa047250.84121143
73African trypanosomiasis_Homo sapiens_hsa051430.82624881
74Oxytocin signaling pathway_Homo sapiens_hsa049210.82355071
75Legionellosis_Homo sapiens_hsa051340.81459482
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80757311
77Dopaminergic synapse_Homo sapiens_hsa047280.79966336
78Gastric acid secretion_Homo sapiens_hsa049710.78801998
79* GnRH signaling pathway_Homo sapiens_hsa049120.78668082
80* ErbB signaling pathway_Homo sapiens_hsa040120.76210889
81Morphine addiction_Homo sapiens_hsa050320.75864758
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75630592
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75498986
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75097245
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73746310
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73109158
87Collecting duct acid secretion_Homo sapiens_hsa049660.72819854
88* Prolactin signaling pathway_Homo sapiens_hsa049170.72228596
89* Jak-STAT signaling pathway_Homo sapiens_hsa046300.72177323
90Herpes simplex infection_Homo sapiens_hsa051680.71396207
91Asthma_Homo sapiens_hsa053100.70731441
92Circadian entrainment_Homo sapiens_hsa047130.69890062
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69388556
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67976470
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67806746
96Glutamatergic synapse_Homo sapiens_hsa047240.67778767
97HIF-1 signaling pathway_Homo sapiens_hsa040660.67761595
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67659034
99Amoebiasis_Homo sapiens_hsa051460.64859196
100Other glycan degradation_Homo sapiens_hsa005110.64298462
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63918855
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63389753
103Salivary secretion_Homo sapiens_hsa049700.63021526
104Malaria_Homo sapiens_hsa051440.62368712
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62264142
106* Endometrial cancer_Homo sapiens_hsa052130.62193131
107* Proteoglycans in cancer_Homo sapiens_hsa052050.61619767
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61599644
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.61233886
110* Choline metabolism in cancer_Homo sapiens_hsa052310.60396679
111Rap1 signaling pathway_Homo sapiens_hsa040150.60386364
112Epstein-Barr virus infection_Homo sapiens_hsa051690.59974225
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59510834
114* Viral carcinogenesis_Homo sapiens_hsa052030.58345496
115HTLV-I infection_Homo sapiens_hsa051660.55287329
116Vibrio cholerae infection_Homo sapiens_hsa051100.49815808
117Pentose phosphate pathway_Homo sapiens_hsa000300.47001502
118Galactose metabolism_Homo sapiens_hsa000520.46306727
119Bladder cancer_Homo sapiens_hsa052190.46226918
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46012425
121Prion diseases_Homo sapiens_hsa050200.44029178
122Fructose and mannose metabolism_Homo sapiens_hsa000510.43427508
123Notch signaling pathway_Homo sapiens_hsa043300.37240982
124Insulin resistance_Homo sapiens_hsa049310.35035299
125Inositol phosphate metabolism_Homo sapiens_hsa005620.33061450
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.29695994
127Sphingolipid metabolism_Homo sapiens_hsa006000.28289970
128* Insulin signaling pathway_Homo sapiens_hsa049100.27504977

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