GRB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21200606
2L-phenylalanine catabolic process (GO:0006559)7.21200606
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10340957
4L-phenylalanine metabolic process (GO:0006558)7.10340957
5aromatic amino acid family catabolic process (GO:0009074)6.40403266
6sulfur amino acid catabolic process (GO:0000098)5.97272816
7indole-containing compound catabolic process (GO:0042436)5.74081665
8indolalkylamine catabolic process (GO:0046218)5.74081665
9tryptophan catabolic process (GO:0006569)5.74081665
10regulation of acrosome reaction (GO:0060046)5.68046537
11desmosome organization (GO:0002934)5.65977712
12kynurenine metabolic process (GO:0070189)5.64408870
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.62638438
14glyoxylate metabolic process (GO:0046487)5.58127548
15cysteine metabolic process (GO:0006534)5.49374244
16regulation of female receptivity (GO:0045924)5.48130381
17tryptophan metabolic process (GO:0006568)5.45460116
18serine family amino acid catabolic process (GO:0009071)5.24263724
19bile acid biosynthetic process (GO:0006699)5.23063583
20urea metabolic process (GO:0019627)5.20596108
21urea cycle (GO:0000050)5.20596108
22negative regulation of T cell differentiation in thymus (GO:0033085)5.06843494
23regulation of female gonad development (GO:2000194)5.00392201
24negative regulation of fibrinolysis (GO:0051918)4.98572787
25positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.94679362
26high-density lipoprotein particle remodeling (GO:0034375)4.94503008
27homocysteine metabolic process (GO:0050667)4.87996595
28alpha-linolenic acid metabolic process (GO:0036109)4.86258757
29cellular modified amino acid catabolic process (GO:0042219)4.83834916
30oocyte development (GO:0048599)4.83255159
31regulation of DNA methylation (GO:0044030)4.81071880
32citrulline biosynthetic process (GO:0019240)4.81046135
33coenzyme catabolic process (GO:0009109)4.78190123
34nitrogen cycle metabolic process (GO:0071941)4.77707619
35aromatic amino acid family metabolic process (GO:0009072)4.75608935
36female mating behavior (GO:0060180)4.69460079
37regulation of fibrinolysis (GO:0051917)4.68456694
38proline metabolic process (GO:0006560)4.68396811
39protein carboxylation (GO:0018214)4.67869668
40peptidyl-glutamic acid carboxylation (GO:0017187)4.67869668
41glycine metabolic process (GO:0006544)4.66363763
42lysine metabolic process (GO:0006553)4.65596958
43lysine catabolic process (GO:0006554)4.65596958
44regulation of protein activation cascade (GO:2000257)4.65309587
45complement activation, alternative pathway (GO:0006957)4.59873776
46bile acid metabolic process (GO:0008206)4.57595973
47protein kinase C signaling (GO:0070528)4.54308018
48bundle of His cell to Purkinje myocyte communication (GO:0086069)4.51033176
49alpha-amino acid catabolic process (GO:1901606)4.47560622
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.42715123
51serine family amino acid metabolic process (GO:0009069)4.39645161
52amino-acid betaine metabolic process (GO:0006577)4.39334654
53negative regulation of sterol transport (GO:0032372)4.35092606
54negative regulation of cholesterol transport (GO:0032375)4.35092606
55regulation of complement activation (GO:0030449)4.34422364
56reverse cholesterol transport (GO:0043691)4.34184043
57regulation of cholesterol esterification (GO:0010872)4.34179393
58regulation of water loss via skin (GO:0033561)4.31940985
59acylglycerol homeostasis (GO:0055090)4.31363516
60triglyceride homeostasis (GO:0070328)4.31363516
61imidazole-containing compound metabolic process (GO:0052803)4.29853026
62tyrosine metabolic process (GO:0006570)4.29129303
63lung epithelium development (GO:0060428)4.28545210
64cellular amino acid catabolic process (GO:0009063)4.28374907
65establishment of skin barrier (GO:0061436)4.28372311
66regulation of triglyceride catabolic process (GO:0010896)4.24700498
67bile acid and bile salt transport (GO:0015721)4.20945431
68protein-lipid complex remodeling (GO:0034368)4.17269035
69macromolecular complex remodeling (GO:0034367)4.17269035
70plasma lipoprotein particle remodeling (GO:0034369)4.17269035
71serine family amino acid biosynthetic process (GO:0009070)4.16511189
72phospholipid efflux (GO:0033700)4.16383111
73indolalkylamine metabolic process (GO:0006586)4.06638114
74drug catabolic process (GO:0042737)4.06461106
75cellular ketone body metabolic process (GO:0046950)3.95724766
76regulation of cholesterol homeostasis (GO:2000188)3.95455766
77glutamate metabolic process (GO:0006536)3.94667000
78ethanol oxidation (GO:0006069)3.93113073
79regulation of transcription from RNA polymerase I promoter (GO:0006356)3.91755077
80cellular glucuronidation (GO:0052695)3.91386006
81cellular biogenic amine catabolic process (GO:0042402)3.87414139
82amine catabolic process (GO:0009310)3.87414139
83drug metabolic process (GO:0017144)3.86210934
84regulation of bile acid biosynthetic process (GO:0070857)3.83732649
85benzene-containing compound metabolic process (GO:0042537)3.83048067
86mitotic chromosome condensation (GO:0007076)3.78044429
87plasma lipoprotein particle clearance (GO:0034381)3.77692390
88flavonoid metabolic process (GO:0009812)3.71953918
89urate metabolic process (GO:0046415)3.71423547
90cofactor catabolic process (GO:0051187)3.67183962
91primary alcohol catabolic process (GO:0034310)3.66566872
92carboxylic acid catabolic process (GO:0046395)3.65577148
93organic acid catabolic process (GO:0016054)3.65577148
94aldehyde catabolic process (GO:0046185)3.65348675
95meiotic cell cycle (GO:0051321)3.64149699
96cholesterol efflux (GO:0033344)3.63051488
97proline biosynthetic process (GO:0006561)3.62361950
98drug transmembrane transport (GO:0006855)3.61435795
99piRNA metabolic process (GO:0034587)3.60022653
100arginine metabolic process (GO:0006525)3.59879002
101intestinal cholesterol absorption (GO:0030299)3.59617361
102plasma lipoprotein particle assembly (GO:0034377)3.56999975
103multicellular organism reproduction (GO:0032504)3.55071514
104heme transport (GO:0015886)3.54123165
105cholesterol homeostasis (GO:0042632)3.51307055
106short-chain fatty acid metabolic process (GO:0046459)3.51026848
107epoxygenase P450 pathway (GO:0019373)3.50403392
108positive regulation of lipoprotein lipase activity (GO:0051006)3.49778844
109positive regulation of triglyceride lipase activity (GO:0061365)3.49778844
110response to nitrosative stress (GO:0051409)3.47163362
111uronic acid metabolic process (GO:0006063)3.46764429
112glucuronate metabolic process (GO:0019585)3.46764429
113sterol homeostasis (GO:0055092)3.46610011
114hormone catabolic process (GO:0042447)3.44407601
115dicarboxylic acid biosynthetic process (GO:0043650)3.42867272
116exogenous drug catabolic process (GO:0042738)3.42554533
117citrulline metabolic process (GO:0000052)3.41889543
118acetyl-CoA metabolic process (GO:0006084)3.41542549
119synaptonemal complex assembly (GO:0007130)3.41230680
120fibrinolysis (GO:0042730)3.38880175
121ketone body metabolic process (GO:1902224)3.38383752
122aspartate family amino acid catabolic process (GO:0009068)3.36173024
123lipoprotein metabolic process (GO:0042157)3.35676348
124multicellular organismal water homeostasis (GO:0050891)3.34414411
125phosphate ion homeostasis (GO:0055062)3.34206993
126trivalent inorganic anion homeostasis (GO:0072506)3.34206993
127complement activation, classical pathway (GO:0006958)3.33288004
128epithelial cell-cell adhesion (GO:0090136)3.32105099
129cell-cell junction maintenance (GO:0045217)3.26119933
130DNA methylation involved in gamete generation (GO:0043046)3.22612725
131C21-steroid hormone biosynthetic process (GO:0006700)3.18908825
132RNA localization (GO:0006403)3.16124943
133regulation of RNA export from nucleus (GO:0046831)3.11909956
134negative regulation of histone methylation (GO:0031061)3.10359700
135positive regulation of hormone metabolic process (GO:0032352)3.07571203
136histone H3-K9 demethylation (GO:0033169)3.02505607
137negative regulation of keratinocyte proliferation (GO:0010839)3.00779349
138female gamete generation (GO:0007292)3.00169168
1394-hydroxyproline metabolic process (GO:0019471)2.98868875
140paraxial mesoderm development (GO:0048339)2.95547607
141intestinal epithelial cell development (GO:0060576)2.92834709
142phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92357909
143regulation of histone H3-K9 methylation (GO:0051570)2.92000528
144maintenance of gastrointestinal epithelium (GO:0030277)2.91221866
145regulation of cholesterol biosynthetic process (GO:0045540)2.90222013
146water homeostasis (GO:0030104)2.86208198
147face development (GO:0060324)2.85066994
148positive regulation of hormone biosynthetic process (GO:0046886)2.84084940
149synaptonemal complex organization (GO:0070193)2.82531493
150regulation of spindle organization (GO:0090224)2.81500620
151progesterone metabolic process (GO:0042448)2.81005734
152positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80925365
153regulation of nucleobase-containing compound transport (GO:0032239)2.80733914
154activation of Rac GTPase activity (GO:0032863)2.80301004
155protein-lipid complex assembly (GO:0065005)2.78441281
156cell junction maintenance (GO:0034331)2.78241518
157regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.77103895
158branching involved in mammary gland duct morphogenesis (GO:0060444)2.76655698
159positive regulation of humoral immune response (GO:0002922)2.74955734
160binding of sperm to zona pellucida (GO:0007339)2.71758378
161C21-steroid hormone metabolic process (GO:0008207)2.69899968
162very-low-density lipoprotein particle assembly (GO:0034379)2.69093767
163gene silencing by RNA (GO:0031047)2.68884137
164Golgi transport vesicle coating (GO:0048200)2.67474128
165COPI coating of Golgi vesicle (GO:0048205)2.67474128
166negative regulation of reproductive process (GO:2000242)2.67264771
167reproduction (GO:0000003)2.65810059
168intestinal absorption (GO:0050892)2.64956426
169regulation of G0 to G1 transition (GO:0070316)2.64397477
170positive regulation of chromosome segregation (GO:0051984)2.64177403
171regulation of transcription from RNA polymerase III promoter (GO:0006359)2.62302289
172establishment of epithelial cell polarity (GO:0090162)2.61287512
173regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.60910054
174ectoderm development (GO:0007398)2.60418088
175protein localization to kinetochore (GO:0034501)2.60233727
176protein localization to chromosome, centromeric region (GO:0071459)2.59144025
177regulation of steroid hormone biosynthetic process (GO:0090030)2.55552740
178positive regulation of histone H3-K4 methylation (GO:0051571)2.51996991
179positive regulation of steroid biosynthetic process (GO:0010893)2.50998269
180keratinization (GO:0031424)2.50754894
181embryonic camera-type eye development (GO:0031076)2.50287880
182regulation of metalloenzyme activity (GO:0048552)2.49636211
183columnar/cuboidal epithelial cell development (GO:0002066)2.48939636
184receptor catabolic process (GO:0032801)2.46527427
185positive regulation of steroid metabolic process (GO:0045940)2.46260195
186positive regulation of reproductive process (GO:2000243)2.45360499
187nucleotide-sugar biosynthetic process (GO:0009226)2.44728634
188regulation of cardioblast differentiation (GO:0051890)2.44428337
189positive regulation of epidermal cell differentiation (GO:0045606)2.44217685
190positive regulation of cellular amine metabolic process (GO:0033240)2.42792497
191nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42479021
192GDP-mannose metabolic process (GO:0019673)2.41874634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.85653775
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.00886544
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.30192729
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.50006951
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.34076742
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.37490551
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.35611835
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14804834
9E2F7_22180533_ChIP-Seq_HELA_Human3.43100875
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.40470229
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36966850
12ESR1_20079471_ChIP-ChIP_T-47D_Human3.14702625
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.93566645
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30926787
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30926787
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30926787
17EZH2_22144423_ChIP-Seq_EOC_Human2.22572889
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12870151
19RUNX1_27514584_Chip-Seq_MCF-7_Human2.07593270
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97456595
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.91505396
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87474341
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79727212
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79432259
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71117618
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66599051
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63888579
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56970659
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56312491
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52377492
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49421215
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49112668
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47865210
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.44407318
35CLOCK_20551151_ChIP-Seq_293T_Human1.44094780
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43486563
37SMC4_20622854_ChIP-Seq_HELA_Human1.41526464
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40794178
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37331875
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37202366
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37035960
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33843611
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.32731916
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32675211
45KLF5_25053715_ChIP-Seq_YYC3_Human1.31113789
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.30338824
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26378448
48* GATA4_25053715_ChIP-Seq_YYC3_Human1.25742619
49* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25550143
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24639256
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.24268633
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.23812635
53GATA1_22025678_ChIP-Seq_K562_Human1.23581168
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23536986
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23463121
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23275590
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22562754
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21747370
59TCF7_22412390_ChIP-Seq_EML_Mouse1.20582490
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19912585
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19158970
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18603590
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17959995
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17140821
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16667616
66GATA6_25053715_ChIP-Seq_YYC3_Human1.16656233
67* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15605824
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.14300450
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13419859
70AHR_22903824_ChIP-Seq_MCF-7_Human1.11394751
71KDM2B_26808549_Chip-Seq_K562_Human1.11286367
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10404304
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08716481
74SOX2_20726797_ChIP-Seq_SW620_Human1.07980912
75* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05514656
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.05160405
77TP63_22573176_ChIP-Seq_HFKS_Human1.04992698
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04701722
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04701722
80* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03985585
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03917682
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.03491118
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02657345
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01403095
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01352398
86* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00230098
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99770542
88* ELF5_23300383_ChIP-Seq_T47D_Human0.99644105
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98529725
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95325685
91AR_21909140_ChIP-Seq_LNCAP_Human0.95171234
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94784896
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93628777
94* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93295797
95P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93204085
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93201457
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92806845
98ZNF263_19887448_ChIP-Seq_K562_Human0.92779573
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92326996
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91715873
101RACK7_27058665_Chip-Seq_MCF-7_Human0.91389800
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89640981
103RARA_24833708_ChIP-Seq_LIVER_Mouse0.88230594
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86386852
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.86102304
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85183389
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85056099
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84926926
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84387683
110LXR_22292898_ChIP-Seq_THP-1_Human0.84378949
111NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82607321
112* FOXO3_23340844_ChIP-Seq_DLD1_Human0.80785818
113SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78768692
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77904803
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77579128
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76779118
117IRF1_19129219_ChIP-ChIP_H3396_Human0.76748848
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75726531
119NANOG_16518401_ChIP-PET_MESCs_Mouse0.74637619
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73122807
121* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71962539
122* ATF3_27146783_Chip-Seq_COLON_Human0.70283711
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70193939
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.68460762
125E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68356579
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68039000
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67550404
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67230799
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66878754
130HTT_18923047_ChIP-ChIP_STHdh_Human0.66596576
131BCOR_27268052_Chip-Seq_Bcells_Human0.65317972
132NANOG_18692474_ChIP-Seq_MESCs_Mouse0.65199495
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64267564
134* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63984870
135MYC_18555785_ChIP-Seq_MESCs_Mouse0.63217772
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62395415
137* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62055929
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61934077
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.60184372
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58731833
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58547375
142KAP1_27257070_Chip-Seq_ESCs_Mouse0.58396414
143P68_20966046_ChIP-Seq_HELA_Human0.57644647
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.57565773
145CREB1_26743006_Chip-Seq_LNCaP_Human0.56922539
146* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.56901241
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.55784679
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.55321965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.54005369
2MP0005360_urolithiasis7.03007991
3MP0005085_abnormal_gallbladder_physiolo5.79014154
4MP0005365_abnormal_bile_salt5.60623075
5MP0008875_abnormal_xenobiotic_pharmacok4.66816375
6MP0003806_abnormal_nucleotide_metabolis4.24766613
7MP0000566_synostosis4.20397525
8MP0003252_abnormal_bile_duct3.66674341
9MP0010329_abnormal_lipoprotein_level3.14625914
10MP0009840_abnormal_foam_cell2.89974967
11MP0003941_abnormal_skin_development2.87114971
12MP0005083_abnormal_biliary_tract2.77082056
13MP0001666_abnormal_nutrient_absorption2.75189718
14MP0005332_abnormal_amino_acid2.74117715
15MP0003195_calcinosis2.65213279
16MP0004019_abnormal_vitamin_homeostasis2.48358540
17MP0002254_reproductive_system_inflammat2.26862402
18MP0002138_abnormal_hepatobiliary_system2.24637463
19MP0009780_abnormal_chondrocyte_physiolo2.21175207
20MP0010030_abnormal_orbit_morphology2.10793305
21MP0003191_abnormal_cellular_cholesterol2.10202818
22MP0004264_abnormal_extraembryonic_tissu2.09492940
23MP0002089_abnormal_postnatal_growth/wei2.06920310
24MP0000609_abnormal_liver_physiology2.03027186
25MP0005076_abnormal_cell_differentiation2.01967252
26MP0003693_abnormal_embryo_hatching1.99993161
27MP0003011_delayed_dark_adaptation1.88578677
28MP0005319_abnormal_enzyme/_coenzyme1.80392851
29MP0000579_abnormal_nail_morphology1.80115265
30MP0002118_abnormal_lipid_homeostasis1.78270666
31MP0003705_abnormal_hypodermis_morpholog1.76698882
32MP0003123_paternal_imprinting1.75919800
33MP0010678_abnormal_skin_adnexa1.74228647
34MP0003183_abnormal_peptide_metabolism1.65097851
35MP0003868_abnormal_feces_composition1.64918023
36MP0000762_abnormal_tongue_morphology1.61222065
37MP0009643_abnormal_urine_homeostasis1.60769495
38MP0005409_darkened_coat_color1.49549809
39MP0003699_abnormal_female_reproductive1.42909306
40MP0001730_embryonic_growth_arrest1.40884836
41MP0000467_abnormal_esophagus_morphology1.40460369
42MP0000627_abnormal_mammary_gland1.39472596
43MP0000383_abnormal_hair_follicle1.39287852
44MP0001764_abnormal_homeostasis1.38457677
45MP0010234_abnormal_vibrissa_follicle1.36118294
46MP0004084_abnormal_cardiac_muscle1.35921385
47MP0003186_abnormal_redox_activity1.35518111
48MP0008932_abnormal_embryonic_tissue1.35048896
49MP0003566_abnormal_cell_adhesion1.34819979
50MP0003879_abnormal_hair_cell1.30367894
51MP0003950_abnormal_plasma_membrane1.23704577
52MP0005584_abnormal_enzyme/coenzyme_acti1.23375286
53MP0005451_abnormal_body_composition1.21671734
54MP0002249_abnormal_larynx_morphology1.21418923
55MP0000598_abnormal_liver_morphology1.17281070
56MP0008789_abnormal_olfactory_epithelium1.16548704
57MP0005380_embryogenesis_phenotype1.14628162
58MP0003077_abnormal_cell_cycle1.14442748
59MP0004043_abnormal_pH_regulation1.13508176
60MP0006292_abnormal_olfactory_placode1.12505259
61MP0003111_abnormal_nucleus_morphology1.09076633
62MP0005636_abnormal_mineral_homeostasis1.08630450
63MP0000003_abnormal_adipose_tissue1.05178013
64MP0000858_altered_metastatic_potential1.03759898
65MP0002796_impaired_skin_barrier1.03041876
66MP0000537_abnormal_urethra_morphology1.00460210
67MP0008057_abnormal_DNA_replication0.98228694
68MP0001929_abnormal_gametogenesis0.97299679
69MP0005499_abnormal_olfactory_system0.94574462
70MP0005394_taste/olfaction_phenotype0.94574462
71MP0002210_abnormal_sex_determination0.94161953
72MP0001756_abnormal_urination0.93317350
73MP0006035_abnormal_mitochondrial_morpho0.92490152
74MP0003890_abnormal_embryonic-extraembry0.91193248
75MP0005220_abnormal_exocrine_pancreas0.91068416
76MP0003936_abnormal_reproductive_system0.90368250
77MP0009697_abnormal_copulation0.87932069
78MP0002282_abnormal_trachea_morphology0.87445864
79MP0006036_abnormal_mitochondrial_physio0.87429515
80MP0005647_abnormal_sex_gland0.85925431
81MP0002086_abnormal_extraembryonic_tissu0.85897329
82MP0003122_maternal_imprinting0.85818458
83MP0008058_abnormal_DNA_repair0.84798608
84MP0005266_abnormal_metabolism0.84294468
85MP0002161_abnormal_fertility/fecundity0.83861212
86MP0003115_abnormal_respiratory_system0.83637574
87MP0003984_embryonic_growth_retardation0.81993362
88MP0010771_integument_phenotype0.81752101
89MP0002108_abnormal_muscle_morphology0.81025419
90MP0002085_abnormal_embryonic_tissue0.80947552
91MP0005408_hypopigmentation0.78873720
92MP0002111_abnormal_tail_morphology0.78859878
93MP0002088_abnormal_embryonic_growth/wei0.78454243
94MP0001881_abnormal_mammary_gland0.78394369
95MP0003121_genomic_imprinting0.77897768
96MP0001270_distended_abdomen0.77828380
97MP0000653_abnormal_sex_gland0.76930798
98MP0000750_abnormal_muscle_regeneration0.76900866
99MP0002078_abnormal_glucose_homeostasis0.76702018
100MP0005376_homeostasis/metabolism_phenot0.76361380
101MP0004782_abnormal_surfactant_physiolog0.76178434
102MP0009642_abnormal_blood_homeostasis0.75794969
103MP0002084_abnormal_developmental_patter0.75485485
104MP0009763_increased_sensitivity_to0.75336498
105MP0005084_abnormal_gallbladder_morpholo0.75254268
106MP0001697_abnormal_embryo_size0.74905444
107MP0004185_abnormal_adipocyte_glucose0.74715105
108MP0002080_prenatal_lethality0.73720716
109MP0010094_abnormal_chromosome_stability0.73017173
110MP0005377_hearing/vestibular/ear_phenot0.72872904
111MP0003878_abnormal_ear_physiology0.72872904
112MP0009053_abnormal_anal_canal0.71862053
113MP0010368_abnormal_lymphatic_system0.71692523
114MP0002136_abnormal_kidney_physiology0.71347448
115MP0009765_abnormal_xenobiotic_induced0.69262387
116MP0010352_gastrointestinal_tract_polyps0.67992270
117MP0002098_abnormal_vibrissa_morphology0.67354296
118MP0009764_decreased_sensitivity_to0.67163635
119MP0005670_abnormal_white_adipose0.66404737
120MP0008469_abnormal_protein_level0.65449413
121MP0000678_abnormal_parathyroid_gland0.63373338
122MP0003656_abnormal_erythrocyte_physiolo0.63191408
123MP0002928_abnormal_bile_duct0.60650183
124MP0005248_abnormal_Harderian_gland0.57882182
125MP0003718_maternal_effect0.57524201
126MP0009672_abnormal_birth_weight0.56857652
127MP0005075_abnormal_melanosome_morpholog0.56496204
128MP0002876_abnormal_thyroid_physiology0.54965054
129MP0001849_ear_inflammation0.53829820
130MP0002132_abnormal_respiratory_system0.52588899
131MP0005395_other_phenotype0.51742669
132MP0005501_abnormal_skin_physiology0.51374247
133MP0001765_abnormal_ion_homeostasis0.51261241
134MP0000604_amyloidosis0.50544728
135MP0008961_abnormal_basal_metabolism0.49841920
136MP0002970_abnormal_white_adipose0.49349454
137MP0003453_abnormal_keratinocyte_physiol0.48796294
138MP0005334_abnormal_fat_pad0.46363148
139MP0001661_extended_life_span0.45972563
140MP0003119_abnormal_digestive_system0.44146120
141MP0001944_abnormal_pancreas_morphology0.43419618
142MP0000639_abnormal_adrenal_gland0.43240027
143MP0003638_abnormal_response/metabolism_0.43202595
144MP0005448_abnormal_energy_balance0.43058951
145MP0005023_abnormal_wound_healing0.42957443
146MP0002971_abnormal_brown_adipose0.42956190
147MP0005257_abnormal_intraocular_pressure0.42950482
148MP0008872_abnormal_physiological_respon0.42733093
149MP0008873_increased_physiological_sensi0.40859992
150MP0003953_abnormal_hormone_level0.39907196
151MP0002332_abnormal_exercise_endurance0.38358438
152MP0004957_abnormal_blastocyst_morpholog0.38345909
153MP0000477_abnormal_intestine_morphology0.37220018
154MP0003300_gastrointestinal_ulcer0.37170489
155MP0002092_abnormal_eye_morphology0.36674634
156MP0000377_abnormal_hair_follicle0.36537981
157MP0001216_abnormal_epidermal_layer0.35781197
158MP0005666_abnormal_adipose_tissue0.35540737
159MP0002060_abnormal_skin_morphology0.34097920
160MP0001243_abnormal_dermal_layer0.33938556
161MP0006082_CNS_inflammation0.33208163
162MP0001672_abnormal_embryogenesis/_devel0.32072183

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.97554010
2Intrahepatic cholestasis (HP:0001406)6.75598620
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.42010373
4Ependymoma (HP:0002888)6.35281504
5Deep venous thrombosis (HP:0002625)6.06957329
6Xanthomatosis (HP:0000991)5.64649876
7Hypobetalipoproteinemia (HP:0003563)5.58756256
8Prolonged partial thromboplastin time (HP:0003645)5.18664081
9Lip pit (HP:0100267)4.77504892
10Abnormality of the astrocytes (HP:0100707)4.68569888
11Astrocytoma (HP:0009592)4.68569888
12Hyperglycinuria (HP:0003108)4.60954782
13Hyperlipoproteinemia (HP:0010980)4.49089699
14Hyperammonemia (HP:0001987)4.49081927
15Hyperglycinemia (HP:0002154)4.37417339
16Complement deficiency (HP:0004431)4.30069776
17Ketosis (HP:0001946)4.23246207
18Hypolipoproteinemia (HP:0010981)4.21476015
19Abnormality of glycine metabolism (HP:0010895)4.19287159
20Abnormality of serine family amino acid metabolism (HP:0010894)4.19287159
21Hypoglycemic coma (HP:0001325)4.16849313
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15078371
23Gout (HP:0001997)4.06066892
24Abnormality of the intrinsic pathway (HP:0010989)4.05445762
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.04470988
26Right ventricular cardiomyopathy (HP:0011663)4.00540360
27Hypochromic microcytic anemia (HP:0004840)3.89880142
28Joint hemorrhage (HP:0005261)3.88589395
29Fat malabsorption (HP:0002630)3.77793704
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.77367804
31Stomach cancer (HP:0012126)3.74479374
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74273242
33Epidermoid cyst (HP:0200040)3.71387256
34Abnormality of pyrimidine metabolism (HP:0004353)3.69044963
35Hypoalphalipoproteinemia (HP:0003233)3.68063549
36Abnormality of the common coagulation pathway (HP:0010990)3.66739335
37Abnormality of methionine metabolism (HP:0010901)3.63172596
38Glioma (HP:0009733)3.52545250
39Flat acetabular roof (HP:0003180)3.47722558
40Ketoacidosis (HP:0001993)3.46428776
41Hyperinsulinemic hypoglycemia (HP:0000825)3.43808569
42Malnutrition (HP:0004395)3.41358357
43Conjugated hyperbilirubinemia (HP:0002908)3.40562250
44Abnormality of nucleobase metabolism (HP:0010932)3.35764056
45Pili torti (HP:0003777)3.29025853
46Abnormality of complement system (HP:0005339)3.21657655
47Abnormality of purine metabolism (HP:0004352)3.19123603
48Osteomalacia (HP:0002749)3.15817872
49Hypercholesterolemia (HP:0003124)3.09879625
50Abnormality of fatty-acid metabolism (HP:0004359)3.07672120
51Hyperbilirubinemia (HP:0002904)2.97821328
52Delayed CNS myelination (HP:0002188)2.96324679
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93717059
54Hypophosphatemic rickets (HP:0004912)2.87524936
55Skin nodule (HP:0200036)2.84867604
56Male infertility (HP:0003251)2.83688389
57Hypoglycemic seizures (HP:0002173)2.81664591
58Abnormal cartilage morphology (HP:0002763)2.81323594
59Metabolic acidosis (HP:0001942)2.80865518
60Hepatocellular carcinoma (HP:0001402)2.80395546
61Late onset (HP:0003584)2.75075596
62Abnormality of serum amino acid levels (HP:0003112)2.72384513
63Steatorrhea (HP:0002570)2.71270741
64Cholecystitis (HP:0001082)2.66542686
65Abnormal hair laboratory examination (HP:0003328)2.66301293
66Dicarboxylic aciduria (HP:0003215)2.65225709
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65225709
68Hypotrichosis (HP:0001006)2.65170693
69Abnormal tarsal ossification (HP:0008369)2.63321768
70Abnormality of the salivary glands (HP:0010286)2.61747942
71Abnormality of nail color (HP:0100643)2.60944796
72Lethargy (HP:0001254)2.58563025
73Spastic diplegia (HP:0001264)2.57913220
74Irritability (HP:0000737)2.57792377
75Hyperuricemia (HP:0002149)2.55201496
76Increased purine levels (HP:0004368)2.55201496
77Sparse lateral eyebrow (HP:0005338)2.54140106
78Vascular calcification (HP:0004934)2.49539156
79Hepatoblastoma (HP:0002884)2.47463677
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42917172
81Spontaneous abortion (HP:0005268)2.42776233
82Advanced eruption of teeth (HP:0006288)2.42213174
83Concave nail (HP:0001598)2.41796459
84Multiple enchondromatosis (HP:0005701)2.40081229
85Enlarged kidneys (HP:0000105)2.34497194
86Esophageal varix (HP:0002040)2.32994811
87Heterotopia (HP:0002282)2.32805108
88Proximal tubulopathy (HP:0000114)2.32262775
89Hyperactive renin-angiotensin system (HP:0000841)2.30430235
90Rickets (HP:0002748)2.28541444
91Pterygium (HP:0001059)2.27108328
92Nasolacrimal duct obstruction (HP:0000579)2.26799613
93Bronchomalacia (HP:0002780)2.26602980
94Generalized aminoaciduria (HP:0002909)2.25861212
95Abnormal enzyme/coenzyme activity (HP:0012379)2.25200151
96Sparse eyelashes (HP:0000653)2.23570719
97Symptomatic seizures (HP:0011145)2.23074734
98Myocardial infarction (HP:0001658)2.22686989
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19873136
100Abnormality of carpal bone ossification (HP:0006257)2.18242887
101Alkalosis (HP:0001948)2.16549171
102Abnormality of the lacrimal duct (HP:0011481)2.16349501
103Taurodontia (HP:0000679)2.15739181
104Abnormality of permanent molar morphology (HP:0011071)2.15739181
105Abnormality of the dental root (HP:0006486)2.15739181
106Vomiting (HP:0002013)2.15592541
107Cardiovascular calcification (HP:0011915)2.13367537
108Hyperglycemia (HP:0003074)2.12529294
109Abnormal gallbladder morphology (HP:0012437)2.11202166
110Popliteal pterygium (HP:0009756)2.11110812
111Alveolar cell carcinoma (HP:0006519)2.06373986
112Skin pits (HP:0100276)2.05720931
113Abnormality of alkaline phosphatase activity (HP:0004379)2.05565538
114Neonatal onset (HP:0003623)2.04807470
115Bifid scrotum (HP:0000048)2.04739025
116Septate vagina (HP:0001153)2.03406192
117Abnormality of the pancreatic islet cells (HP:0006476)2.01857994
118Abnormality of endocrine pancreas physiology (HP:0012093)2.01857994
119Abnormality of the lower motor neuron (HP:0002366)2.00993477
120Pancreatitis (HP:0001733)2.00517606
121Cholelithiasis (HP:0001081)1.98750447
122Abnormality of transition element cation homeostasis (HP:0011030)1.96866487
123Abnormality of the dental pulp (HP:0006479)1.94561829
124Abnormality of vitamin metabolism (HP:0100508)1.93872707
125Abnormality of molar (HP:0011077)1.92955236
126Abnormality of molar morphology (HP:0011070)1.92955236
127Papillary thyroid carcinoma (HP:0002895)1.92209149
128Small epiphyses (HP:0010585)1.89671285
129Congenital ichthyosiform erythroderma (HP:0007431)1.89356466
130Subcapsular cataract (HP:0000523)1.89347768
131Increased nuchal translucency (HP:0010880)1.89201035
132Spinal cord compression (HP:0002176)1.89106875
133Elevated alkaline phosphatase (HP:0003155)1.88983100
134Ragged-red muscle fibers (HP:0003200)1.88634933
135Systemic lupus erythematosus (HP:0002725)1.88246167
136Glycosuria (HP:0003076)1.87198300
137Abnormality of urine glucose concentration (HP:0011016)1.87198300
138Brushfield spots (HP:0001088)1.86745075
139Alopecia of scalp (HP:0002293)1.86214927
140Facial hemangioma (HP:0000329)1.86194936
141Abnormality of proline metabolism (HP:0010907)1.85959153
142Hydroxyprolinuria (HP:0003080)1.85959153
143Cerebral edema (HP:0002181)1.85651241
144Premature ovarian failure (HP:0008209)1.85573023
145Neonatal death (HP:0003811)1.85431976
146Broad nasal tip (HP:0000455)1.85025130
147Pseudobulbar signs (HP:0002200)1.84548968
148Acanthocytosis (HP:0001927)1.84155009
149Abnormality of iron homeostasis (HP:0011031)1.82247066
150Amyloidosis (HP:0011034)1.82166151
151Natal tooth (HP:0000695)1.80412630
152Neoplasm of the tracheobronchial system (HP:0100552)1.79889461
153Impulsivity (HP:0100710)1.79389204
154Abnormal foot bone ossification (HP:0010675)1.78779728
155Abnormality of the nasal septum (HP:0000419)1.78099622
156Abnormality of the nasolacrimal system (HP:0000614)1.77370735
157Partial duplication of thumb phalanx (HP:0009944)1.75879973
158Pancreatic islet-cell hyperplasia (HP:0004510)1.75859516
159Nephrolithiasis (HP:0000787)1.75566455
160Hypokinesia (HP:0002375)1.74763713
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74547920
162Absent epiphyses (HP:0010577)1.74547920
163Broad alveolar ridges (HP:0000187)1.74208304
164Abnormal ossification of hand bones (HP:0005921)1.73972837
165Abnormal hand bone ossification (HP:0010660)1.72576842
166Abnormal gallbladder physiology (HP:0012438)1.72289845
167Glomerulosclerosis (HP:0000096)1.72267999
168Focal segmental glomerulosclerosis (HP:0000097)1.72097280
169Capillary hemangiomas (HP:0005306)1.71095533
170Blepharitis (HP:0000498)1.68027310
171Urethral obstruction (HP:0000796)1.67436392
172Severe Myopia (HP:0011003)1.67217748
173Hemorrhage of the eye (HP:0011885)1.66736733
174Oligodontia (HP:0000677)1.64534734
175Deviation of the thumb (HP:0009603)1.64127383
176Absent eyelashes (HP:0000561)1.63430144
177Milia (HP:0001056)1.63053998
178Fragile nails (HP:0001808)1.62378618
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62178119
180Anal stenosis (HP:0002025)1.61227215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.59656644
2BCKDK5.20519238
3CDK123.99594634
4EPHA23.25586923
5GRK63.05379261
6FGFR43.02144142
7MAP3K92.90272819
8SIK12.87585814
9MST1R2.48919082
10MAP3K132.12631228
11TAOK31.93604700
12INSRR1.90541941
13STK241.86863139
14MAP3K101.83843777
15GRK11.82428160
16LATS11.80064607
17ERBB41.79585769
18GRK51.72494384
19MAPK151.67998953
20ARAF1.67829457
21TTK1.62562634
22FRK1.61663854
23STK38L1.58770557
24SMG11.57845540
25FLT31.53642603
26NEK61.46245527
27PTK61.44877501
28PKN21.40700011
29EEF2K1.40216960
30MET1.36836685
31STK101.36234292
32WNK31.35697089
33TGFBR21.35141369
34NME11.32635864
35STK391.30376145
36MAPK71.27643391
37TRIB31.24655564
38MAP2K41.23703696
39MAP2K61.21396027
40MAP2K21.20850867
41AKT31.15973652
42MAPK111.15946632
43MAP3K31.13223000
44PIK3CG1.10834102
45PRKG21.08761944
46CSF1R1.03522755
47PAK41.01328032
48* PTK21.01174313
49ERBB20.98890172
50WNK40.96829885
51DYRK1B0.96737235
52BRSK10.94143856
53ADRBK20.87891494
54FGFR10.87865717
55RPS6KB20.87698601
56MELK0.87633758
57MAP3K70.86836288
58NME20.86752894
59MAP3K20.86580645
60MTOR0.80789435
61PBK0.80305526
62CDK70.72451541
63BMX0.70815269
64BUB10.70377158
65KDR0.68668975
66PDGFRA0.68558082
67MATK0.68544101
68TYK20.68240098
69PRKCI0.68136318
70CSK0.67567513
71JAK20.67352244
72IRAK30.67319871
73NEK20.67153522
74RIPK10.64590543
75ABL20.63182839
76MAPKAPK30.63082571
77CDK90.62600011
78TSSK60.61656540
79FGFR30.61531353
80BRAF0.61460314
81MAP2K30.60287314
82MAP3K60.59510048
83GSK3A0.59244682
84CDK40.58393360
85NEK10.57209957
86TESK10.55621793
87CAMK40.54141076
88HIPK20.51905167
89PRKAA20.50658273
90TRIM280.50525139
91MARK20.49996206
92MAP3K80.49491340
93AKT20.49490454
94CDC42BPA0.48930792
95CDK60.48529708
96CHEK10.48404287
97DAPK20.48207061
98MAP3K110.46882182
99KSR20.46341678
100TAOK10.45816548
101TYRO30.45027302
102NEK90.43827565
103RET0.43762281
104PRKAA10.43342706
105PRKACG0.43225321
106CDK80.42813464
107FER0.42537602
108EPHB10.41135130
109WNK10.40672284
110BRSK20.40543222
111MAP3K10.38937567
112MST40.38732031
113CDK20.36897927
114NTRK10.36585378
115CDK10.35472230
116PASK0.35240979
117EGFR0.35120432
118CSNK1E0.35079880
119MAP2K10.34173353
120STK380.34102228
121IGF1R0.33505680
122MAPK40.33042372
123PRKCZ0.32739511
124MOS0.32715939
125LRRK20.32211047
126LATS20.31931396
127EPHA30.31777173
128MAPK120.30537169
129ITK0.30032351
130PLK10.29538422
131CHUK0.29453279
132GRK70.28599012
133AURKA0.28082796
134FGFR20.27527514
135ICK0.27118242
136DMPK0.26115468
137STK30.26029632
138DYRK30.25971514
139PDPK10.25951883
140OXSR10.25699474
141LMTK20.25251213
142AURKB0.25116461
143CAMK1D0.24803722
144EIF2AK30.24765903
145NTRK30.24671491
146GSK3B0.24414186
147SIK30.24187372
148CDK150.23416287
149CDK180.21929582
150CDK11A0.21916875

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96556943
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46439877
3Nitrogen metabolism_Homo sapiens_hsa009103.25112420
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00103262
5Arginine biosynthesis_Homo sapiens_hsa002202.79906915
6Tryptophan metabolism_Homo sapiens_hsa003802.77971689
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64738323
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57509650
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56573472
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49979409
11Fatty acid degradation_Homo sapiens_hsa000712.39850430
12Complement and coagulation cascades_Homo sapiens_hsa046102.38091120
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22024196
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17862381
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10961458
16Butanoate metabolism_Homo sapiens_hsa006502.04422347
17Adherens junction_Homo sapiens_hsa045202.03843830
18Chemical carcinogenesis_Homo sapiens_hsa052042.01348080
19Peroxisome_Homo sapiens_hsa041461.97118038
20Histidine metabolism_Homo sapiens_hsa003401.95844720
21Selenocompound metabolism_Homo sapiens_hsa004501.84378131
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.82966639
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.81231410
24Propanoate metabolism_Homo sapiens_hsa006401.76095198
25Cell cycle_Homo sapiens_hsa041101.71985525
26PPAR signaling pathway_Homo sapiens_hsa033201.69753650
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.68758208
28Base excision repair_Homo sapiens_hsa034101.68634023
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65053974
30beta-Alanine metabolism_Homo sapiens_hsa004101.64850638
31Folate biosynthesis_Homo sapiens_hsa007901.64286200
32Retinol metabolism_Homo sapiens_hsa008301.63991733
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61211956
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60127298
35Sulfur metabolism_Homo sapiens_hsa009201.54434222
36Fatty acid metabolism_Homo sapiens_hsa012121.54168017
37Tight junction_Homo sapiens_hsa045301.51637233
38Phenylalanine metabolism_Homo sapiens_hsa003601.51580481
39Bile secretion_Homo sapiens_hsa049761.49776955
40Endometrial cancer_Homo sapiens_hsa052131.49165185
41Caffeine metabolism_Homo sapiens_hsa002321.43451989
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41695306
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.41209630
44Basal transcription factors_Homo sapiens_hsa030221.40949213
45Fat digestion and absorption_Homo sapiens_hsa049751.40282622
46Pyruvate metabolism_Homo sapiens_hsa006201.40177184
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.40144422
48Vitamin B6 metabolism_Homo sapiens_hsa007501.39924942
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36131925
50Tyrosine metabolism_Homo sapiens_hsa003501.35666359
51Biosynthesis of amino acids_Homo sapiens_hsa012301.30179269
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29599236
53Starch and sucrose metabolism_Homo sapiens_hsa005001.27219446
54Carbon metabolism_Homo sapiens_hsa012001.25640021
55Notch signaling pathway_Homo sapiens_hsa043301.25537276
56Staphylococcus aureus infection_Homo sapiens_hsa051501.24254043
57Mismatch repair_Homo sapiens_hsa034301.17625601
58Sulfur relay system_Homo sapiens_hsa041221.17401992
59One carbon pool by folate_Homo sapiens_hsa006701.14223089
60Non-small cell lung cancer_Homo sapiens_hsa052231.13781373
61Sphingolipid metabolism_Homo sapiens_hsa006001.12701795
62ABC transporters_Homo sapiens_hsa020101.12241792
63Hippo signaling pathway_Homo sapiens_hsa043901.12112612
64Circadian rhythm_Homo sapiens_hsa047101.11734900
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10604910
66mRNA surveillance pathway_Homo sapiens_hsa030151.06540027
67Arginine and proline metabolism_Homo sapiens_hsa003301.04458220
68ErbB signaling pathway_Homo sapiens_hsa040121.02269928
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98678221
70Fatty acid elongation_Homo sapiens_hsa000620.98144547
71Prostate cancer_Homo sapiens_hsa052150.98136268
72Vitamin digestion and absorption_Homo sapiens_hsa049770.97860603
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93812106
74Glutathione metabolism_Homo sapiens_hsa004800.92640274
75Steroid biosynthesis_Homo sapiens_hsa001000.92439567
76MicroRNAs in cancer_Homo sapiens_hsa052060.92307567
77Insulin signaling pathway_Homo sapiens_hsa049100.91832944
78DNA replication_Homo sapiens_hsa030300.91386699
79RNA transport_Homo sapiens_hsa030130.90856988
80Pancreatic cancer_Homo sapiens_hsa052120.90094308
81Lysine degradation_Homo sapiens_hsa003100.89132000
82Fructose and mannose metabolism_Homo sapiens_hsa000510.88738251
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85436208
84Inositol phosphate metabolism_Homo sapiens_hsa005620.84131458
85Oocyte meiosis_Homo sapiens_hsa041140.82948721
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79968773
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77174499
88Small cell lung cancer_Homo sapiens_hsa052220.76991021
89Glycerolipid metabolism_Homo sapiens_hsa005610.76286000
90Galactose metabolism_Homo sapiens_hsa000520.75262296
91N-Glycan biosynthesis_Homo sapiens_hsa005100.75243378
92ECM-receptor interaction_Homo sapiens_hsa045120.75065538
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74427719
94Pentose phosphate pathway_Homo sapiens_hsa000300.74082667
95Proteoglycans in cancer_Homo sapiens_hsa052050.67790846
96HIF-1 signaling pathway_Homo sapiens_hsa040660.64887815
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64874208
98p53 signaling pathway_Homo sapiens_hsa041150.61337805
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61304611
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60174141
101TGF-beta signaling pathway_Homo sapiens_hsa043500.60156286
102Linoleic acid metabolism_Homo sapiens_hsa005910.58776148
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57910730
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53527846
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53327482
106Metabolic pathways_Homo sapiens_hsa011000.52658437
107Thyroid hormone synthesis_Homo sapiens_hsa049180.52390367
108mTOR signaling pathway_Homo sapiens_hsa041500.51974802
109Fanconi anemia pathway_Homo sapiens_hsa034600.51373709
110Nucleotide excision repair_Homo sapiens_hsa034200.50165233
111Dorso-ventral axis formation_Homo sapiens_hsa043200.50126376
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48850034
113Focal adhesion_Homo sapiens_hsa045100.48810006
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41902171
115Arachidonic acid metabolism_Homo sapiens_hsa005900.28500264
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.24966529
117Insulin resistance_Homo sapiens_hsa049310.22487226
118Prion diseases_Homo sapiens_hsa050200.22001022
119Fatty acid biosynthesis_Homo sapiens_hsa000610.15944942
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.11950984
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.11596389
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09992333
123Renin-angiotensin system_Homo sapiens_hsa046140.09957981
124Bladder cancer_Homo sapiens_hsa052190.06855451
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06010855
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05617553
127AMPK signaling pathway_Homo sapiens_hsa041520.05502449
128Glucagon signaling pathway_Homo sapiens_hsa049220.03868473
129Mineral absorption_Homo sapiens_hsa049780.01817018
130Thyroid cancer_Homo sapiens_hsa052160.00794117
131Protein digestion and absorption_Homo sapiens_hsa049740.00452628
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1456630
133Ether lipid metabolism_Homo sapiens_hsa00565-0.1419994
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.1311209
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1307728
136Hepatitis C_Homo sapiens_hsa05160-0.0923928
137Pyrimidine metabolism_Homo sapiens_hsa00240-0.0697279
138Other glycan degradation_Homo sapiens_hsa00511-0.0635240
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0614151
140Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0366192
141Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0331915
142Regulation of autophagy_Homo sapiens_hsa04140-0.0169360

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