GREB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1estrogen biosynthetic process (GO:0006703)8.73307332
2androgen biosynthetic process (GO:0006702)5.87243841
3pre-miRNA processing (GO:0031054)5.79847663
4paraxial mesoderm development (GO:0048339)5.47621259
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.16772404
6cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.02689374
7cardiac right ventricle morphogenesis (GO:0003215)4.92900721
8ear development (GO:0043583)4.73771768
9embryonic camera-type eye morphogenesis (GO:0048596)4.65467206
10cellular response to cadmium ion (GO:0071276)4.43729927
11regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.42926906
12embryonic eye morphogenesis (GO:0048048)4.38516812
13embryonic retina morphogenesis in camera-type eye (GO:0060059)4.34548107
14DNA unwinding involved in DNA replication (GO:0006268)4.16034523
15biotin metabolic process (GO:0006768)4.15834449
16lateral sprouting from an epithelium (GO:0060601)4.09610943
17response to follicle-stimulating hormone (GO:0032354)4.05346322
18glucocorticoid biosynthetic process (GO:0006704)4.04297681
19anterior/posterior axis specification, embryo (GO:0008595)4.03758955
20regulation of fatty acid beta-oxidation (GO:0031998)3.99130630
21proximal/distal pattern formation (GO:0009954)3.98914746
22estrogen metabolic process (GO:0008210)3.97339865
23regulation of mesoderm development (GO:2000380)3.94545201
24uterus development (GO:0060065)3.93142546
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.90737701
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.89890723
27epithelial cell maturation (GO:0002070)3.87020363
28embryonic foregut morphogenesis (GO:0048617)3.83476792
29positive regulation of keratinocyte differentiation (GO:0045618)3.81128838
30C21-steroid hormone biosynthetic process (GO:0006700)3.79911794
31insulin-like growth factor receptor signaling pathway (GO:0048009)3.76902166
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71854848
33gastrulation with mouth forming second (GO:0001702)3.65650200
34positive regulation of gastrulation (GO:2000543)3.61245412
35amyloid precursor protein catabolic process (GO:0042987)3.60953784
36polarized epithelial cell differentiation (GO:0030859)3.59722413
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.57707304
38establishment of apical/basal cell polarity (GO:0035089)3.57202942
39primitive streak formation (GO:0090009)3.55519244
40endothelial cell chemotaxis (GO:0035767)3.53361367
41establishment of planar polarity (GO:0001736)3.52731888
42establishment of tissue polarity (GO:0007164)3.52731888
43heterochromatin organization (GO:0070828)3.50814350
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.50146395
45regulation of establishment or maintenance of cell polarity (GO:0032878)3.46372425
46negative regulation of cell fate specification (GO:0009996)3.44778154
47vagina development (GO:0060068)3.44643600
48negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44604718
49negative regulation of sodium ion transport (GO:0010766)3.44161241
50organ induction (GO:0001759)3.41098316
51regulation of centriole replication (GO:0046599)3.40851710
52positive regulation of hormone metabolic process (GO:0032352)3.40796464
53outer ear morphogenesis (GO:0042473)3.38641396
54regulation of cell proliferation involved in kidney development (GO:1901722)3.38517447
55exocrine pancreas development (GO:0031017)3.37468597
56artery development (GO:0060840)3.37353081
57mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.36470870
58hippo signaling (GO:0035329)3.33586708
59positive regulation of cell size (GO:0045793)3.29581022
60branching involved in mammary gland duct morphogenesis (GO:0060444)3.29574968
61hindlimb morphogenesis (GO:0035137)3.28205755
62regulation of organ formation (GO:0003156)3.28053554
63regulation of sister chromatid cohesion (GO:0007063)3.27090796
64female genitalia development (GO:0030540)3.26584959
65embryonic skeletal joint morphogenesis (GO:0060272)3.25659891
66regulation of establishment of cell polarity (GO:2000114)3.23806253
67cellular zinc ion homeostasis (GO:0006882)3.21840482
68regulation of cholesterol biosynthetic process (GO:0045540)3.19186420
69establishment or maintenance of monopolar cell polarity (GO:0061339)3.16156677
70establishment of monopolar cell polarity (GO:0061162)3.16156677
71regulation of stem cell maintenance (GO:2000036)3.15228950
72androgen metabolic process (GO:0008209)3.14905083
73midgut development (GO:0007494)3.12338778
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.11126764
75regulation of gene silencing by RNA (GO:0060966)3.08945292
76regulation of posttranscriptional gene silencing (GO:0060147)3.08945292
77regulation of gene silencing by miRNA (GO:0060964)3.08945292
78glucocorticoid receptor signaling pathway (GO:0042921)3.08605837
79positive regulation of glycogen biosynthetic process (GO:0045725)3.08444720
80intestinal epithelial cell development (GO:0060576)3.08065678
81cell migration involved in gastrulation (GO:0042074)3.06783227
82lung-associated mesenchyme development (GO:0060484)3.05195102
83sex determination (GO:0007530)3.04734349
84male genitalia development (GO:0030539)3.04223613
85negative regulation of embryonic development (GO:0045992)3.04064710
86peptidyl-arginine omega-N-methylation (GO:0035247)3.03680296
87nuclear pore organization (GO:0006999)3.03434678
88prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.03024499
89regulation of gonadotropin secretion (GO:0032276)3.01606660
90cellular response to gonadotropin stimulus (GO:0071371)3.01269358
91head development (GO:0060322)3.01267142
92embryonic hindlimb morphogenesis (GO:0035116)2.99271237
93notochord development (GO:0030903)2.99243849
94prostate gland growth (GO:0060736)2.99169308
95negative regulation of RNA splicing (GO:0033119)2.98566850
96striated muscle atrophy (GO:0014891)2.96594375
97face development (GO:0060324)2.93031585
98cardiac ventricle morphogenesis (GO:0003208)2.92606588
99phosphate ion homeostasis (GO:0055062)2.92295404
100trivalent inorganic anion homeostasis (GO:0072506)2.92295404
101negative regulation of mRNA processing (GO:0050686)2.91934074
102positive regulation of fatty acid oxidation (GO:0046321)2.91107212
103progesterone metabolic process (GO:0042448)2.91098840
104post-anal tail morphogenesis (GO:0036342)2.87470073
105negative regulation of DNA repair (GO:0045738)2.87448642
106urogenital system development (GO:0001655)2.85494280
107adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.84761729
108nuclear pore complex assembly (GO:0051292)2.83872559
109regulation of transforming growth factor beta2 production (GO:0032909)2.83679104
110mesenchyme development (GO:0060485)2.83648813
111positive regulation of embryonic development (GO:0040019)2.82560129
112negative regulation of organelle assembly (GO:1902116)2.82179132
113oocyte development (GO:0048599)2.82100221
114signal transduction involved in regulation of gene expression (GO:0023019)2.82018982
115gastrulation (GO:0007369)2.81088970
116negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.80382885
117epithelial cell-cell adhesion (GO:0090136)2.79985369
118mitotic sister chromatid cohesion (GO:0007064)2.79678097
119cell surface receptor signaling pathway involved in heart development (GO:0061311)2.79595557
120glucocorticoid metabolic process (GO:0008211)2.78684360
121mesonephros development (GO:0001823)2.78460533
122protein-DNA complex disassembly (GO:0032986)2.78349711
123nucleosome disassembly (GO:0006337)2.78349711
124positive regulation of nitric-oxide synthase activity (GO:0051000)2.78167600
125convergent extension (GO:0060026)2.78011188
126regulation of axon extension involved in axon guidance (GO:0048841)2.77797264
127establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.77689490
128epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.77601997
129peptidyl-arginine N-methylation (GO:0035246)2.76969523
130peptidyl-arginine methylation (GO:0018216)2.76969523
131anterior/posterior axis specification (GO:0009948)2.76923390
132negative regulation of fatty acid transport (GO:2000192)2.75683083
133non-canonical Wnt signaling pathway (GO:0035567)2.75154159
134cochlea morphogenesis (GO:0090103)2.75147438
135forelimb morphogenesis (GO:0035136)2.75103151
136alternative mRNA splicing, via spliceosome (GO:0000380)2.74819129
137embryonic forelimb morphogenesis (GO:0035115)2.74578182
138branching involved in salivary gland morphogenesis (GO:0060445)2.74286221
139desmosome organization (GO:0002934)2.74098810
140apical protein localization (GO:0045176)2.74041047
141innervation (GO:0060384)2.73482464
142DNA replication-dependent nucleosome organization (GO:0034723)2.73230759
143DNA replication-dependent nucleosome assembly (GO:0006335)2.73230759
144positive regulation of glycogen metabolic process (GO:0070875)2.72576086
145cell migration in hindbrain (GO:0021535)2.72453743
146dorsal/ventral neural tube patterning (GO:0021904)2.70841913
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.70827643
148positive regulation of epithelial to mesenchymal transition (GO:0010718)2.70316024
149endocardial cushion development (GO:0003197)2.70169023
150cell-cell junction maintenance (GO:0045217)2.70010603
151cell proliferation involved in metanephros development (GO:0072203)2.69470465
152embryonic skeletal system development (GO:0048706)2.69197104
153Leydig cell differentiation (GO:0033327)2.68520476
154appendage morphogenesis (GO:0035107)2.67058670
155limb morphogenesis (GO:0035108)2.67058670
156ectodermal placode formation (GO:0060788)2.66142669
157regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.65060899
158positive regulation of epidermal cell differentiation (GO:0045606)2.64927849
159mammary gland epithelial cell differentiation (GO:0060644)2.64596784
160L-alpha-amino acid transmembrane transport (GO:1902475)2.63521759
161outflow tract septum morphogenesis (GO:0003148)2.62057705
162maternal placenta development (GO:0001893)2.61699773
163skeletal muscle adaptation (GO:0043501)2.58399200
164semaphorin-plexin signaling pathway (GO:0071526)2.56188372
165limb bud formation (GO:0060174)2.55037386
166negative regulation of cell size (GO:0045792)2.54009839
167eye morphogenesis (GO:0048592)2.50306708
168body morphogenesis (GO:0010171)2.49174907
169negative regulation of axon extension involved in axon guidance (GO:0048843)2.48463347
170regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.48177453
171epithelial tube branching involved in lung morphogenesis (GO:0060441)2.48040113
172cardiac chamber morphogenesis (GO:0003206)2.47809516
173mammary gland alveolus development (GO:0060749)2.47618743
174muscle atrophy (GO:0014889)2.47509312
175regulation of axon guidance (GO:1902667)2.45091987
176negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.44967091
177negative regulation of Ras GTPase activity (GO:0034261)2.44566638
178zinc ion transmembrane transport (GO:0071577)2.39803918
179positive regulation of smoothened signaling pathway (GO:0045880)2.39745171
180norepinephrine metabolic process (GO:0042415)2.37683740
181glomerular basement membrane development (GO:0032836)2.36698020
182chondrocyte development (GO:0002063)2.36147748
183negative regulation of cell fate commitment (GO:0010454)2.35584070
184asymmetric protein localization (GO:0008105)2.32569241
185peptidyl-lysine dimethylation (GO:0018027)2.31754602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.17469714
2* ESR1_21235772_ChIP-Seq_MCF-7_Human5.82608391
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.27530641
4* ESR2_21235772_ChIP-Seq_MCF-7_Human5.20239449
5* TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.37879718
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.37635008
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29706550
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29563332
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human3.18916118
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.10215916
11* RUNX1_27514584_Chip-Seq_MCF-7_Human3.03022933
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02548974
13AR_21909140_ChIP-Seq_LNCAP_Human3.01065780
14AHR_22903824_ChIP-Seq_MCF-7_Human2.94917295
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.90351876
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.82370680
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70125110
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.60288704
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.57820808
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.43937899
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.39613419
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.35771963
23ZNF263_19887448_ChIP-Seq_K562_Human2.35298518
24ARNT_22903824_ChIP-Seq_MCF-7_Human2.30223670
25RACK7_27058665_Chip-Seq_MCF-7_Human2.25497373
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25472698
27* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.21012818
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03102953
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01982543
30* GATA3_24758297_ChIP-Seq_MCF-7_Human1.97069643
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95303125
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94714325
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94517609
34ER_23166858_ChIP-Seq_MCF-7_Human1.93248287
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88194005
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87690057
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.87555995
38CLOCK_20551151_ChIP-Seq_293T_Human1.86972689
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86934272
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86929696
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85615015
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83851130
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83814660
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.83307149
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83095810
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81515341
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80885365
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80885365
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80885365
50* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80292361
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.79752052
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76189286
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.75017999
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71443529
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69413547
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.64632418
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62084581
58XRN2_22483619_ChIP-Seq_HELA_Human1.59910290
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.59154400
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58297663
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57984302
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.56732178
63FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.55123739
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54850541
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.52481451
66* NANOG_16153702_ChIP-ChIP_HESCs_Human1.49927148
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48669166
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.48626114
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47797952
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47235639
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.45691493
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45112027
73MYC_22102868_ChIP-Seq_BL_Human1.44161735
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43461373
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41615695
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40898781
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40822932
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.37833946
79* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31456098
80TTF2_22483619_ChIP-Seq_HELA_Human1.30571608
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30403551
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29813266
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27171330
84KDM2B_26808549_Chip-Seq_K562_Human1.26888636
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25336008
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24372722
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24372722
88KDM5A_27292631_Chip-Seq_BREAST_Human1.23944857
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23944432
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.22960154
91CIITA_25753668_ChIP-Seq_RAJI_Human1.19996196
92CREB1_26743006_Chip-Seq_LNCaP_Human1.19948624
93CHD1_26751641_Chip-Seq_LNCaP_Human1.19046270
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18981354
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18706633
96TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17595497
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17474653
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16009064
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15996065
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15597948
101* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15331010
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12850883
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11771768
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.11111327
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10884314
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09011824
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08968008
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08014966
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07717843
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07309210
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.06258738
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05524464
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05521696
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03677133
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02019482
116MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01083149
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00941519
118GATA6_25053715_ChIP-Seq_YYC3_Human0.99065906
119DROSHA_22980978_ChIP-Seq_HELA_Human0.98885557
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.98714737
121POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98160282
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97696667
123PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97222873
124SMC4_20622854_ChIP-Seq_HELA_Human0.97207803
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97139713
126RXR_22158963_ChIP-Seq_LIVER_Mouse0.96917960
127* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96496445
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95789255
129LXR_22292898_ChIP-Seq_THP-1_Human0.93228169
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92558628
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92190312
132AR_21572438_ChIP-Seq_LNCaP_Human0.90857514
133* FOXA1_25552417_ChIP-Seq_VCAP_Human0.89978215
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89306208
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.89251522
136TCF7_22412390_ChIP-Seq_EML_Mouse0.88473753
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87978082
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87890725
139* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86626534
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86544847
141* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86362326
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86118011
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.86043684
144ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85402060
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84430235
146* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84113221
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84053693
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83326110
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83118960
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82740275
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82633873
152* ESR1_20079471_ChIP-ChIP_T-47D_Human0.81931100
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.81505637
154* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76905108
155STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.74032714
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73811246
157SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73328450
158HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72925849
159ELF5_23300383_ChIP-Seq_T47D_Human0.72800245
160SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.72202645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.75542758
2MP0009053_abnormal_anal_canal3.71413971
3MP0000537_abnormal_urethra_morphology3.58598251
4MP0003123_paternal_imprinting3.38341582
5MP0003122_maternal_imprinting2.95990792
6MP0003315_abnormal_perineum_morphology2.87304266
7MP0005408_hypopigmentation2.63488710
8MP0003121_genomic_imprinting2.60805575
9MP0004264_abnormal_extraembryonic_tissu2.53565859
10MP0003283_abnormal_digestive_organ2.52869727
11MP0003937_abnormal_limbs/digits/tail_de2.39536065
12MP0004233_abnormal_muscle_weight2.32609558
13MP0003890_abnormal_embryonic-extraembry2.23251040
14MP0003385_abnormal_body_wall2.18573143
15MP0009250_abnormal_appendicular_skeleto2.16711123
16MP0002932_abnormal_joint_morphology2.16103864
17MP0000566_synostosis2.08205805
18MP0003119_abnormal_digestive_system2.07053836
19MP0003942_abnormal_urinary_system2.06881872
20MP0009780_abnormal_chondrocyte_physiolo1.99881529
21MP0002822_catalepsy1.95992496
22MP0005423_abnormal_somatic_nervous1.93245354
23MP0002249_abnormal_larynx_morphology1.91694665
24MP0003011_delayed_dark_adaptation1.90393119
25MP0002282_abnormal_trachea_morphology1.88123480
26MP0000049_abnormal_middle_ear1.87927760
27MP0000534_abnormal_ureter_morphology1.84285431
28MP0002751_abnormal_autonomic_nervous1.84100423
29MP0003115_abnormal_respiratory_system1.83489688
30MP0002084_abnormal_developmental_patter1.78251891
31MP0002909_abnormal_adrenal_gland1.77337634
32MP0003567_abnormal_fetal_cardiomyocyte1.76283995
33MP0004957_abnormal_blastocyst_morpholog1.73397207
34MP0005248_abnormal_Harderian_gland1.67187461
35MP0002111_abnormal_tail_morphology1.66914537
36MP0002085_abnormal_embryonic_tissue1.60589126
37MP0000428_abnormal_craniofacial_morphol1.59189082
38MP0001293_anophthalmia1.58058224
39MP0004197_abnormal_fetal_growth/weight/1.57237796
40MP0008932_abnormal_embryonic_tissue1.56110957
41MP0005646_abnormal_pituitary_gland1.54368413
42MP0003935_abnormal_craniofacial_develop1.50513740
43MP0002254_reproductive_system_inflammat1.49294672
44MP0003077_abnormal_cell_cycle1.47931379
45MP0002653_abnormal_ependyma_morphology1.46356379
46MP0003111_abnormal_nucleus_morphology1.46339428
47MP0004381_abnormal_hair_follicle1.43911131
48MP0005503_abnormal_tendon_morphology1.43859351
49MP0002098_abnormal_vibrissa_morphology1.43548606
50MP0005187_abnormal_penis_morphology1.42235703
51MP0002114_abnormal_axial_skeleton1.40313523
52MP0003693_abnormal_embryo_hatching1.39750888
53MP0002102_abnormal_ear_morphology1.39513923
54MP0002184_abnormal_innervation1.39483623
55MP0005380_embryogenesis_phenotype1.39265596
56MP0001672_abnormal_embryogenesis/_devel1.39265596
57MP0002938_white_spotting1.37965106
58MP0004185_abnormal_adipocyte_glucose1.36725879
59MP0000427_abnormal_hair_cycle1.35744569
60MP0002234_abnormal_pharynx_morphology1.35069921
61MP0005076_abnormal_cell_differentiation1.35024244
62MP0005409_darkened_coat_color1.34846004
63MP0000627_abnormal_mammary_gland1.34389729
64MP0000733_abnormal_muscle_development1.33184444
65MP0003941_abnormal_skin_development1.32724854
66MP0004272_abnormal_basement_membrane1.32678735
67MP0001730_embryonic_growth_arrest1.32669648
68MP0005623_abnormal_meninges_morphology1.32076657
69MP0010094_abnormal_chromosome_stability1.30500934
70MP0002116_abnormal_craniofacial_bone1.27636572
71MP0003938_abnormal_ear_development1.26304326
72MP0009672_abnormal_birth_weight1.26166446
73MP0002233_abnormal_nose_morphology1.24874896
74MP0000639_abnormal_adrenal_gland1.23854663
75MP0010329_abnormal_lipoprotein_level1.22858358
76MP0002160_abnormal_reproductive_system1.21866566
77MP0000432_abnormal_head_morphology1.21532914
78MP0010678_abnormal_skin_adnexa1.21225137
79MP0001881_abnormal_mammary_gland1.21137401
80MP0003755_abnormal_palate_morphology1.21121764
81MP0001529_abnormal_vocalization1.21088552
82MP0001697_abnormal_embryo_size1.21069108
83MP0003984_embryonic_growth_retardation1.20805780
84MP0002088_abnormal_embryonic_growth/wei1.20293385
85MP0000350_abnormal_cell_proliferation1.19845189
86MP0002009_preneoplasia1.19386477
87MP0002092_abnormal_eye_morphology1.19259438
88MP0004133_heterotaxia1.19010492
89MP0006054_spinal_hemorrhage1.18687262
90MP0002109_abnormal_limb_morphology1.16602374
91MP0003705_abnormal_hypodermis_morpholog1.16272287
92MP0002697_abnormal_eye_size1.15704239
93MP0005389_reproductive_system_phenotype1.15625931
94MP0005647_abnormal_sex_gland1.14246864
95MP0009384_cardiac_valve_regurgitation1.14146982
96MP0003195_calcinosis1.13592073
97MP0003861_abnormal_nervous_system1.12401755
98MP0008438_abnormal_cutaneous_collagen1.11674347
99MP0003136_yellow_coat_color1.10718756
100MP0001664_abnormal_digestion1.06157114
101MP0003936_abnormal_reproductive_system1.04797993
102MP0002086_abnormal_extraembryonic_tissu1.04138313
103MP0003880_abnormal_central_pattern1.03345947
104MP0008057_abnormal_DNA_replication1.01969886
105MP0000462_abnormal_digestive_system1.01293841
106MP0010234_abnormal_vibrissa_follicle1.01074235
107MP0003787_abnormal_imprinting1.00973861
108MP0001286_abnormal_eye_development0.98931244
109MP0002075_abnormal_coat/hair_pigmentati0.98121458
110MP0001919_abnormal_reproductive_system0.96919700
111MP0002796_impaired_skin_barrier0.96801303
112MP0000371_diluted_coat_color0.96457610
113MP0010352_gastrointestinal_tract_polyps0.96364570
114MP0001873_stomach_inflammation0.96109544
115MP0008007_abnormal_cellular_replicative0.95627419
116MP0009703_decreased_birth_body0.95446023
117MP0000538_abnormal_urinary_bladder0.95389133
118MP0005508_abnormal_skeleton_morphology0.94501064
119MP0002736_abnormal_nociception_after0.93829032
120MP0002896_abnormal_bone_mineralization0.93699083
121MP0001340_abnormal_eyelid_morphology0.93218664
122MP0008995_early_reproductive_senescence0.92830600
123MP0002925_abnormal_cardiovascular_devel0.91181192
124MP0009278_abnormal_bone_marrow0.90885474
125MP0000767_abnormal_smooth_muscle0.90768778
126MP0001346_abnormal_lacrimal_gland0.90433104
127MP0004858_abnormal_nervous_system0.90284897
128MP0001186_pigmentation_phenotype0.89926193
129MP0001666_abnormal_nutrient_absorption0.89747000
130MP0000383_abnormal_hair_follicle0.89206877
131MP0000631_abnormal_neuroendocrine_gland0.88928526
132MP0002080_prenatal_lethality0.88308515
133MP0002089_abnormal_postnatal_growth/wei0.88235710
134MP0001849_ear_inflammation0.87049806
135MP0002115_abnormal_skeleton_extremities0.85562185
136MP0002108_abnormal_muscle_morphology0.84452424
137MP0001299_abnormal_eye_distance/0.82982110
138MP0001915_intracranial_hemorrhage0.82297682
139MP0000163_abnormal_cartilage_morphology0.82014764
140MP0005075_abnormal_melanosome_morpholog0.81602683
141MP0004782_abnormal_surfactant_physiolog0.80877216
142MP0000470_abnormal_stomach_morphology0.79555591
143MP0000579_abnormal_nail_morphology0.76325568
144MP0002557_abnormal_social/conspecific_i0.75434957
145MP0003878_abnormal_ear_physiology0.74039099
146MP0005377_hearing/vestibular/ear_phenot0.74039099
147MP0000377_abnormal_hair_follicle0.73936315
148MP0001968_abnormal_touch/_nociception0.72118967
149MP0003699_abnormal_female_reproductive0.71651212
150MP0000467_abnormal_esophagus_morphology0.70295988
151MP0002877_abnormal_melanocyte_morpholog0.70006496
152MP0005083_abnormal_biliary_tract0.69565717
153MP0001944_abnormal_pancreas_morphology0.69227040
154MP0003953_abnormal_hormone_level0.67833526
155MP0005257_abnormal_intraocular_pressure0.66909532
156MP0001727_abnormal_embryo_implantation0.66225774

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)4.86605710
2J-shaped sella turcica (HP:0002680)4.51048308
3Sex reversal (HP:0012245)4.32968034
4Abnormal sex determination (HP:0012244)4.32968034
5Renal duplication (HP:0000075)3.88650324
6Microglossia (HP:0000171)3.79926220
7Short 4th metacarpal (HP:0010044)3.68527143
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68527143
9Short middle phalanx of the 5th finger (HP:0004220)3.57975324
10Abnormality of the proximal phalanges of the hand (HP:0009834)3.52448386
11Septate vagina (HP:0001153)3.49294135
12Flat acetabular roof (HP:0003180)3.18710778
13Abnormality of the 4th metacarpal (HP:0010012)3.12039683
14Enlarged penis (HP:0000040)3.08023234
15Concave nail (HP:0001598)3.03466816
16Germ cell neoplasia (HP:0100728)2.96044859
17Testicular neoplasm (HP:0010788)2.95473462
18Deformed sella turcica (HP:0002681)2.94927853
19Deep venous thrombosis (HP:0002625)2.86547800
20Absent frontal sinuses (HP:0002688)2.85103612
21Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.83945285
22Selective tooth agenesis (HP:0001592)2.78446685
23Bifid tongue (HP:0010297)2.77485261
24Broad thumb (HP:0011304)2.62763450
25Short 5th finger (HP:0009237)2.60655826
26Shawl scrotum (HP:0000049)2.58774452
27Broad toe (HP:0001837)2.54360265
28Abnormality of carpal bone ossification (HP:0006257)2.54337158
29Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.52104490
30Abnormal number of incisors (HP:0011064)2.50911519
31Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.48473745
32Rib fusion (HP:0000902)2.44681028
33Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.43241944
34Abnormal pancreas size (HP:0012094)2.41716103
35Rectal prolapse (HP:0002035)2.41168659
36Mesomelia (HP:0003027)2.37824119
37Abnormal lung lobation (HP:0002101)2.34518693
38Synostosis of carpal bones (HP:0005048)2.33498555
39Midline defect of the nose (HP:0004122)2.33405292
40Shallow orbits (HP:0000586)2.30980893
41Abnormality of the sella turcica (HP:0002679)2.30886516
42Breast carcinoma (HP:0003002)2.30325933
43Anophthalmia (HP:0000528)2.29063898
44Cupped ribs (HP:0000887)2.26545268
45Oligodactyly (HP:0012165)2.25005851
46Preaxial foot polydactyly (HP:0001841)2.24991833
47Abnormality of the parietal bone (HP:0002696)2.24245384
48Hypoplastic labia majora (HP:0000059)2.23953681
49Abnormality of the 1st metacarpal (HP:0010009)2.23949276
50Broad phalanges of the hand (HP:0009768)2.22557245
51Spinal cord lesions (HP:0100561)2.22120277
52Syringomyelia (HP:0003396)2.22120277
53Abnormal ossification of hand bones (HP:0005921)2.20235010
54Hypopigmentation of the fundus (HP:0007894)2.19978126
55Relative macrocephaly (HP:0004482)2.19929874
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.18857215
57Gonadal dysgenesis (HP:0000133)2.18138251
58Abnormal hand bone ossification (HP:0010660)2.17879573
59High pitched voice (HP:0001620)2.16699208
60Increased number of teeth (HP:0011069)2.16555643
61Broad finger (HP:0001500)2.16312962
62Diastasis recti (HP:0001540)2.15824344
63Bilateral microphthalmos (HP:0007633)2.15536317
64Short humerus (HP:0005792)2.15266986
65Bicornuate uterus (HP:0000813)2.15238326
66Back pain (HP:0003418)2.13427235
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12048819
68Amelogenesis imperfecta (HP:0000705)2.10350947
69Aplasia/hypoplasia of the humerus (HP:0006507)2.10179998
70Anal stenosis (HP:0002025)2.08088431
71Sparse lateral eyebrow (HP:0005338)2.07518677
72Carpal synostosis (HP:0009702)2.07110174
73Bronchomalacia (HP:0002780)2.07042463
74Trigonocephaly (HP:0000243)2.05690407
75Colon cancer (HP:0003003)2.04417958
76Renovascular hypertension (HP:0100817)2.04379802
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03010377
78Abnormality of the labia majora (HP:0012881)2.02844164
79Menstrual irregularities (HP:0000858)2.02645098
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01747223
81Intestinal atresia (HP:0011100)2.01363072
82Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00375118
83Limited elbow extension (HP:0001377)1.99742626
84Increased nuchal translucency (HP:0010880)1.99725374
85Partial duplication of the phalanx of hand (HP:0009999)1.99627949
86Abnormality of the aortic arch (HP:0012303)1.98929124
87Short femoral neck (HP:0100864)1.97496965
88Skull defect (HP:0001362)1.97448040
89Short tibia (HP:0005736)1.97306809
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97170884
91Partial agenesis of the corpus callosum (HP:0001338)1.96971858
92Pseudobulbar signs (HP:0002200)1.96145555
93Short thumb (HP:0009778)1.95465361
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.94784832
95Broad long bones (HP:0005622)1.93392962
96Broad phalanx (HP:0006009)1.92827090
97Absent epiphyses (HP:0010577)1.92640860
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92640860
99Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.91579404
100Supernumerary ribs (HP:0005815)1.91576550
101Small epiphyses (HP:0010585)1.91235260
102Cutaneous syndactyly (HP:0012725)1.91025328
103Abnormality of femoral epiphyses (HP:0006499)1.90168913
104Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90168913
105Spinal cord compression (HP:0002176)1.89868091
106Hyperpituitarism (HP:0010514)1.89425838
107Broad face (HP:0000283)1.89254193
108Narrow palate (HP:0000189)1.89042443
109Sprengel anomaly (HP:0000912)1.88909163
110Renal hypoplasia (HP:0000089)1.88290430
111Abnormality of the 2nd finger (HP:0004100)1.88162527
112Myelomeningocele (HP:0002475)1.88071410
113Abnormal tarsal ossification (HP:0008369)1.87938390
114Cutaneous finger syndactyly (HP:0010554)1.87713912
115Lymphangioma (HP:0100764)1.87141797
116Abnormality of the epiphysis of the femoral head (HP:0010574)1.86963571
117Renal salt wasting (HP:0000127)1.86925122
118Aortic aneurysm (HP:0004942)1.86299520
119Abnormality of the frontal sinuses (HP:0002687)1.86002987
120Proximal placement of thumb (HP:0009623)1.85754006
121Short hallux (HP:0010109)1.84924432
122Macroorchidism (HP:0000053)1.84586907
123Tracheal stenosis (HP:0002777)1.84473655
124Flattened epiphyses (HP:0003071)1.84163102
125Skin tags (HP:0010609)1.84083098
126Testicular atrophy (HP:0000029)1.83747284
127Chromsome breakage (HP:0040012)1.83192040
128Hemivertebrae (HP:0002937)1.83185879
129Supernumerary bones of the axial skeleton (HP:0009144)1.82724618
130Long eyelashes (HP:0000527)1.82639636
131Ulnar claw (HP:0001178)1.82325637
132Coronal craniosynostosis (HP:0004440)1.82209313
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.82168921
134Elfin facies (HP:0004428)1.81764682
135Ankle contracture (HP:0006466)1.81410880
136Facial hemangioma (HP:0000329)1.81238653
137Short phalanx of the thumb (HP:0009660)1.80811543
138Deviation of the thumb (HP:0009603)1.80066627
139Curly hair (HP:0002212)1.79276615
140Preauricular skin tag (HP:0000384)1.77493504
141Oligodactyly (hands) (HP:0001180)1.77121008
142Ectopic kidney (HP:0000086)1.76865218
143Precocious puberty (HP:0000826)1.76808070
144Nephroblastoma (Wilms tumor) (HP:0002667)1.76052985
145Abnormality of the femoral head (HP:0003368)1.75566624
146Abnormality of the pubic bones (HP:0003172)1.75064912
147Broad palm (HP:0001169)1.73097483
148Flared iliac wings (HP:0002869)1.73027552
149Broad hallux (HP:0010055)1.72982108
150Advanced eruption of teeth (HP:0006288)1.72202952
151Abnormality of the right ventricle (HP:0001707)1.71985461
152Hypospadias (HP:0000047)1.71232537
153Broad alveolar ridges (HP:0000187)1.70909322
154Intestinal malrotation (HP:0002566)1.70608666
155Aplasia/Hypoplasia of the patella (HP:0006498)1.70551518
156Short middle phalanx of finger (HP:0005819)1.70210876
157Buphthalmos (HP:0000557)1.70210869
158Overlapping toe (HP:0001845)1.69545154
159Asymmetry of the thorax (HP:0001555)1.69508066
160Overriding aorta (HP:0002623)1.69250754
161Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66793085
162Long toe (HP:0010511)1.66667218
163Aplasia/hypoplasia of the femur (HP:0005613)1.66545901
164Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65594399
165Abnormality of the nasal septum (HP:0000419)1.65319786
166Abnormality of chromosome segregation (HP:0002916)1.64747436
167Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.64604428
168Medulloblastoma (HP:0002885)1.64356073
169Synostosis involving bones of the hand (HP:0004278)1.63934620
170Hyperacusis (HP:0010780)1.63551362
171Renal dysplasia (HP:0000110)1.63512119
172Depressed nasal tip (HP:0000437)1.63376385
173Atresia of the external auditory canal (HP:0000413)1.62451080
174Abnormality of the phalanges of the hallux (HP:0010057)1.62254710
175Aplasia of the phalanges of the hand (HP:0009802)1.62102599
176Fibular aplasia (HP:0002990)1.61669131
177Embryonal renal neoplasm (HP:0011794)1.61434311
178Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60994267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.17947165
2LATS14.02604254
3LATS23.69333578
4CDC73.55115922
5PIK3CA3.42829046
6MAPKAPK33.30771770
7MKNK13.06785162
8MAP3K102.83425210
9CDK122.82469524
10SCYL22.59592062
11EPHB22.58506607
12TSSK62.45722411
13SIK32.37875949
14SMG12.32091029
15FGFR42.29944821
16MKNK22.26939746
17NEK62.22443557
18BRD42.13243659
19PASK2.12042867
20BUB12.06671289
21KSR12.06173321
22TGFBR11.96745747
23CDK71.96587206
24EPHA21.91270001
25PDGFRA1.81980246
26SRPK11.74769411
27STK31.73240640
28BCR1.69774645
29NEK21.64603467
30MAP2K21.63629098
31PAK41.63295300
32TTK1.59519727
33FGFR11.55093741
34WEE11.52353422
35CHUK1.51293881
36AKT31.44871807
37STK38L1.39546168
38ICK1.38669798
39EEF2K1.34152041
40PNCK1.33769296
41PLK31.31078751
42TTN1.24261583
43CDK61.21449265
44MTOR1.14905287
45RET1.14513600
46CDK41.14181439
47ERBB21.13984034
48ERBB31.12841275
49TAF11.11270580
50MAP3K81.09477267
51SIK11.08387694
52RPS6KB11.07321447
53PTK61.05643780
54PAK21.04244076
55PLK11.02286213
56FGFR20.99018806
57NEK10.95892830
58ATR0.95793994
59AURKB0.95372111
60RPS6KB20.94601582
61CHEK10.92648639
62CAMK1G0.90388517
63PRKD30.89898802
64BRSK20.89863147
65RPS6KA20.87837891
66TRIB30.87407542
67CLK10.85940582
68WNK40.83444243
69PRKCI0.82708275
70VRK20.81904348
71UHMK10.79592491
72FGFR30.78477844
73MELK0.78252877
74CDK80.78075717
75ALK0.74786207
76CDK20.73297286
77CDK10.72804713
78PLK40.72774630
79AKT20.72643527
80MAP2K10.70536766
81PAK10.69489371
82LMTK20.69085149
83NTRK20.67223020
84ATM0.66932194
85CSNK1E0.65891266
86RPS6KA40.65825155
87RIPK10.65174069
88CHEK20.65162588
89PTK20.64361332
90SGK2230.62643506
91SGK4940.62643506
92EIF2AK20.62563624
93CSF1R0.62132131
94STK100.60778543
95PDPK10.60234325
96FER0.59151204
97SGK20.58685851
98TAOK10.58503280
99TESK10.58431993
100DYRK1B0.57574215
101GRK60.57357171
102CASK0.56445946
103TYRO30.56175309
104PRKCZ0.55214594
105PRKAA10.54759743
106YES10.54100253
107PRPF4B0.53043345
108TNK20.51391514
109CAMK1D0.49969960
110MAP3K90.49759186
111EIF2AK10.49377084
112SGK30.48111446
113CSNK1A1L0.47111514
114AKT10.47020316
115STK40.46574766
116PDGFRB0.46292334
117LRRK20.45821710
118MAPK80.45642323
119PRKD20.44486092
120PKN20.43992087
121CDK90.43871615
122MINK10.43551048
123CAMK2B0.43487797
124TGFBR20.42583632
125CAMKK10.41740736
126TAOK20.40185356
127MET0.39767541
128MAPK140.38992326
129RPS6KL10.37911761
130RPS6KC10.37911761
131PDK10.37544601
132RPS6KA60.37394174
133AURKA0.37032834
134DMPK0.36848491
135CSNK1G10.36648875
136CAMK2G0.35765617
137CAMK2D0.35706057
138GSK3B0.35487435
139EPHA40.35323454
140MAPKAPK50.34990726
141PRKDC0.34773388
142NLK0.34230871
143ILK0.34048211
144TESK20.33516762
145IRAK30.32918844
146STK380.32538228
147DYRK30.32484767
148BRSK10.32402660
149PLK20.32345864
150MAPK10.31912407
151PRKD10.31529367
152RPS6KA10.31158765
153CSNK1D0.31133753
154CDK180.31009479
155DYRK20.29859907
156SRC0.29704359
157PRKAA20.29539376
158MAPKAPK20.29198785
159MARK20.28861456
160MAPK90.28232427
161MAPK30.26940288
162NME10.23814421

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.58563313
2Hedgehog signaling pathway_Homo sapiens_hsa043403.75586971
3Ovarian steroidogenesis_Homo sapiens_hsa049133.45026991
4Spliceosome_Homo sapiens_hsa030403.21036371
5Hippo signaling pathway_Homo sapiens_hsa043903.13282105
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.79841665
7Cell cycle_Homo sapiens_hsa041102.73674095
8RNA transport_Homo sapiens_hsa030132.49060583
9DNA replication_Homo sapiens_hsa030302.34919157
10TGF-beta signaling pathway_Homo sapiens_hsa043502.31392026
11mRNA surveillance pathway_Homo sapiens_hsa030152.30071441
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.26778052
13Wnt signaling pathway_Homo sapiens_hsa043102.16858488
14Vitamin digestion and absorption_Homo sapiens_hsa049771.95976936
15Mismatch repair_Homo sapiens_hsa034301.86260172
16Adherens junction_Homo sapiens_hsa045201.84925089
17MicroRNAs in cancer_Homo sapiens_hsa052061.80263547
18Notch signaling pathway_Homo sapiens_hsa043301.75980037
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.73268589
20Melanogenesis_Homo sapiens_hsa049161.69275175
21Proteoglycans in cancer_Homo sapiens_hsa052051.66823187
22Oocyte meiosis_Homo sapiens_hsa041141.62087740
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.58657854
24Base excision repair_Homo sapiens_hsa034101.48022164
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45838595
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40466350
27Lysine degradation_Homo sapiens_hsa003101.40428815
28Insulin signaling pathway_Homo sapiens_hsa049101.37837500
29RNA degradation_Homo sapiens_hsa030181.34085264
30HTLV-I infection_Homo sapiens_hsa051661.33551124
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33534061
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33521078
33ABC transporters_Homo sapiens_hsa020101.31586580
34Thyroid cancer_Homo sapiens_hsa052161.27646854
35One carbon pool by folate_Homo sapiens_hsa006701.26228811
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23733333
37Pathways in cancer_Homo sapiens_hsa052001.23457022
38Chronic myeloid leukemia_Homo sapiens_hsa052201.23133133
39Fatty acid metabolism_Homo sapiens_hsa012121.21472526
40Small cell lung cancer_Homo sapiens_hsa052221.21133112
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.18577227
42Bile secretion_Homo sapiens_hsa049761.17913923
43Colorectal cancer_Homo sapiens_hsa052101.16539081
44ECM-receptor interaction_Homo sapiens_hsa045121.16410712
45Choline metabolism in cancer_Homo sapiens_hsa052311.14565582
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.13922181
47Prostate cancer_Homo sapiens_hsa052151.11744668
48Tight junction_Homo sapiens_hsa045301.11253981
49Insulin resistance_Homo sapiens_hsa049311.07252319
50Viral myocarditis_Homo sapiens_hsa054161.06026479
51VEGF signaling pathway_Homo sapiens_hsa043701.05189069
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04710446
53Nucleotide excision repair_Homo sapiens_hsa034201.03449821
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02076942
55Axon guidance_Homo sapiens_hsa043601.01953271
56Fat digestion and absorption_Homo sapiens_hsa049750.99131949
57Endometrial cancer_Homo sapiens_hsa052130.97460544
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.96949559
59Focal adhesion_Homo sapiens_hsa045100.96228282
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92076419
61Melanoma_Homo sapiens_hsa052180.90962709
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90595190
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89138672
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88407635
65Acute myeloid leukemia_Homo sapiens_hsa052210.87089707
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86386777
67Inositol phosphate metabolism_Homo sapiens_hsa005620.84461436
68Prolactin signaling pathway_Homo sapiens_hsa049170.84110835
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82727911
70Bladder cancer_Homo sapiens_hsa052190.82183327
71Fatty acid biosynthesis_Homo sapiens_hsa000610.81869139
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80854967
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75343999
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74798003
75Type II diabetes mellitus_Homo sapiens_hsa049300.74704351
76Pyrimidine metabolism_Homo sapiens_hsa002400.74495158
77Homologous recombination_Homo sapiens_hsa034400.73144690
78Fructose and mannose metabolism_Homo sapiens_hsa000510.73125452
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71799992
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71504171
81RNA polymerase_Homo sapiens_hsa030200.69104548
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68169509
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.67288390
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65149382
85Viral carcinogenesis_Homo sapiens_hsa052030.64633257
86Biosynthesis of amino acids_Homo sapiens_hsa012300.64056569
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62909305
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61870287
89Vibrio cholerae infection_Homo sapiens_hsa051100.61262440
90Estrogen signaling pathway_Homo sapiens_hsa049150.59911369
91Vitamin B6 metabolism_Homo sapiens_hsa007500.59275394
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.59098378
93Rap1 signaling pathway_Homo sapiens_hsa040150.58371807
94Dorso-ventral axis formation_Homo sapiens_hsa043200.57037436
95Nitrogen metabolism_Homo sapiens_hsa009100.56948972
96Butanoate metabolism_Homo sapiens_hsa006500.56656816
97Glioma_Homo sapiens_hsa052140.56146315
98Sulfur relay system_Homo sapiens_hsa041220.55721002
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55400262
100Arginine biosynthesis_Homo sapiens_hsa002200.54464406
101Insulin secretion_Homo sapiens_hsa049110.54261111
102Glutamatergic synapse_Homo sapiens_hsa047240.53768823
103mTOR signaling pathway_Homo sapiens_hsa041500.53341747
104Cholinergic synapse_Homo sapiens_hsa047250.51397862
105Pancreatic cancer_Homo sapiens_hsa052120.50405920
106Propanoate metabolism_Homo sapiens_hsa006400.50288040
107Sphingolipid metabolism_Homo sapiens_hsa006000.49991744
108Glucagon signaling pathway_Homo sapiens_hsa049220.49325004
109Ribosome_Homo sapiens_hsa030100.48339826
110p53 signaling pathway_Homo sapiens_hsa041150.48294412
111Long-term depression_Homo sapiens_hsa047300.48051054
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47134348
113Gap junction_Homo sapiens_hsa045400.46927487
114Basal transcription factors_Homo sapiens_hsa030220.46049889
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45878283
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44865802
117Steroid biosynthesis_Homo sapiens_hsa001000.44480252
118Herpes simplex infection_Homo sapiens_hsa051680.44277936
119Renal cell carcinoma_Homo sapiens_hsa052110.43634962
120Fanconi anemia pathway_Homo sapiens_hsa034600.43336851
121Circadian entrainment_Homo sapiens_hsa047130.43187452
122Epstein-Barr virus infection_Homo sapiens_hsa051690.42832170
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.42225911
124Non-small cell lung cancer_Homo sapiens_hsa052230.41884886
125Tyrosine metabolism_Homo sapiens_hsa003500.40813213
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39336497
127Phenylalanine metabolism_Homo sapiens_hsa003600.39225151
128N-Glycan biosynthesis_Homo sapiens_hsa005100.38954034
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38561995
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37848380
131Thyroid hormone synthesis_Homo sapiens_hsa049180.35702981
132Systemic lupus erythematosus_Homo sapiens_hsa053220.35656677
133FoxO signaling pathway_Homo sapiens_hsa040680.33949803
134HIF-1 signaling pathway_Homo sapiens_hsa040660.33723222
135Alcoholism_Homo sapiens_hsa050340.32964801
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.32373918
137Carbon metabolism_Homo sapiens_hsa012000.32233706
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32097462
139ErbB signaling pathway_Homo sapiens_hsa040120.31438933
140AMPK signaling pathway_Homo sapiens_hsa041520.31292651
141Amoebiasis_Homo sapiens_hsa051460.29666376
142Purine metabolism_Homo sapiens_hsa002300.29162333
143Dilated cardiomyopathy_Homo sapiens_hsa054140.29051247
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28451066
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28263738
146Protein digestion and absorption_Homo sapiens_hsa049740.26636316

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