GREM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)8.14707805
2mesenchymal-epithelial cell signaling (GO:0060638)8.00612952
3virion attachment to host cell (GO:0019062)5.84858859
4adhesion of symbiont to host cell (GO:0044650)5.84858859
5cellular response to vitamin D (GO:0071305)5.74970622
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.69075636
7axon extension involved in axon guidance (GO:0048846)5.69075636
8type B pancreatic cell proliferation (GO:0044342)5.64001378
9* collagen fibril organization (GO:0030199)5.49329143
10sequestering of extracellular ligand from receptor (GO:0035581)5.39412930
11extracellular matrix assembly (GO:0085029)5.20851003
12cell migration involved in heart development (GO:0060973)4.96778770
13endodermal cell differentiation (GO:0035987)4.92784860
14plasma membrane repair (GO:0001778)4.87042563
15adhesion of symbiont to host (GO:0044406)4.85766703
16negative regulation of fatty acid transport (GO:2000192)4.84882808
17cellular response to vitamin (GO:0071295)4.83999998
18decidualization (GO:0046697)4.74363283
19cellular response to ATP (GO:0071318)4.59670295
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.58596952
21response to vitamin D (GO:0033280)4.48298395
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.47476699
23cell adhesion mediated by integrin (GO:0033627)4.46667256
24keratinocyte proliferation (GO:0043616)4.44932098
25regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.44648184
26positive regulation of macrophage activation (GO:0043032)4.44247602
27positive regulation of chemokine secretion (GO:0090197)4.32169522
28substrate-dependent cell migration (GO:0006929)4.29405885
29blood vessel maturation (GO:0001955)4.29402940
30dermatan sulfate biosynthetic process (GO:0030208)4.16880445
31heparan sulfate proteoglycan biosynthetic process (GO:0015012)4.05480774
32bone trabecula formation (GO:0060346)4.05009896
33positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.98875790
34skin morphogenesis (GO:0043589)3.97230741
35protein localization to cell surface (GO:0034394)3.95263663
36positive regulation of fibroblast migration (GO:0010763)3.90810793
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90759099
38outer ear morphogenesis (GO:0042473)3.89955679
39heterochromatin organization (GO:0070828)3.88934761
40protein heterotrimerization (GO:0070208)3.84159713
41extracellular fibril organization (GO:0043206)3.83920419
42regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.71214751
43ovulation (GO:0030728)3.71181924
44dermatan sulfate metabolic process (GO:0030205)3.70440709
45collagen metabolic process (GO:0032963)3.64078266
46regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.62551676
47collagen catabolic process (GO:0030574)3.58670019
48positive regulation of endothelial cell apoptotic process (GO:2000353)3.56465046
49embryonic cranial skeleton morphogenesis (GO:0048701)3.55892411
50regulation of chemokine secretion (GO:0090196)3.51789271
51metanephric mesenchyme development (GO:0072075)3.51546181
52fibril organization (GO:0097435)3.51458244
53G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50893587
54epoxygenase P450 pathway (GO:0019373)3.48568626
55extracellular matrix disassembly (GO:0022617)3.46525831
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.44708275
57tooth mineralization (GO:0034505)3.40613147
58negative regulation of chondrocyte differentiation (GO:0032331)3.38884634
59multicellular organismal macromolecule metabolic process (GO:0044259)3.38602894
60negative regulation of nitric-oxide synthase activity (GO:0051001)3.35538619
61* cell migration involved in sprouting angiogenesis (GO:0002042)3.35430683
62hyaluronan catabolic process (GO:0030214)3.35015752
63regulation of chemokine-mediated signaling pathway (GO:0070099)3.29742704
64regulation of integrin-mediated signaling pathway (GO:2001044)3.28973095
65vascular endothelial growth factor signaling pathway (GO:0038084)3.28472972
66pericardium development (GO:0060039)3.27162634
67response to manganese ion (GO:0010042)3.27075352
68planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26584990
69multicellular organismal catabolic process (GO:0044243)3.25510521
70mRNA transcription (GO:0009299)3.25424815
71positive regulation of extracellular matrix organization (GO:1903055)3.23368104
72hippo signaling (GO:0035329)3.22408015
73positive regulation vascular endothelial growth factor production (GO:0010575)3.20766176
74positive regulation of blood vessel endothelial cell migration (GO:0043536)3.19986734
75germ cell migration (GO:0008354)3.19188610
76middle ear morphogenesis (GO:0042474)3.19132948
77kidney mesenchyme development (GO:0072074)3.18975775
78regulation of plasminogen activation (GO:0010755)3.17661504
79negative chemotaxis (GO:0050919)3.17507478
80multicellular organismal metabolic process (GO:0044236)3.17300633
81negative regulation of smooth muscle cell differentiation (GO:0051151)3.13645420
82regulation of extracellular matrix disassembly (GO:0010715)3.10585599
83heparan sulfate proteoglycan metabolic process (GO:0030201)3.09560102
84protein retention in ER lumen (GO:0006621)3.09516863
85endothelial cell morphogenesis (GO:0001886)3.09494073
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09261596
87peptidyl-proline hydroxylation (GO:0019511)3.09154009
88apoptotic cell clearance (GO:0043277)3.07694223
89cellular response to amino acid stimulus (GO:0071230)3.05758816
90cellular response to prostaglandin stimulus (GO:0071379)3.05643647
91endocardial cushion development (GO:0003197)3.05543904
92hypotonic response (GO:0006971)3.04993188
93venous blood vessel morphogenesis (GO:0048845)3.04227860
94wound healing (GO:0042060)3.03726439
95positive regulation of osteoblast proliferation (GO:0033690)3.02991706
96extracellular regulation of signal transduction (GO:1900115)3.02703880
97extracellular negative regulation of signal transduction (GO:1900116)3.02703880
98* extracellular matrix organization (GO:0030198)3.01697250
99smooth muscle tissue development (GO:0048745)3.01358542
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.00718436
101* extracellular structure organization (GO:0043062)3.00615213
102regulation of cellular senescence (GO:2000772)3.00147279
103epithelial cell-cell adhesion (GO:0090136)2.99646329
104positive regulation of axon extension (GO:0045773)2.99635301
105substrate adhesion-dependent cell spreading (GO:0034446)2.99341206
106sprouting angiogenesis (GO:0002040)2.99022632
107positive regulation of bone remodeling (GO:0046852)2.98670742
108positive regulation of bone resorption (GO:0045780)2.98670742
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94703027
110* negative regulation of BMP signaling pathway (GO:0030514)2.94668855
111axis elongation (GO:0003401)2.94268533
112glomerular basement membrane development (GO:0032836)2.93580936
113chondroitin sulfate biosynthetic process (GO:0030206)2.93314781
114basement membrane organization (GO:0071711)2.92323730
115positive regulation of catecholamine secretion (GO:0033605)2.91996806
116wound healing, spreading of epidermal cells (GO:0035313)2.91666450
117mesodermal cell differentiation (GO:0048333)2.90932695
118craniofacial suture morphogenesis (GO:0097094)2.90697743
119negative regulation of catenin import into nucleus (GO:0035414)2.90695393
120barbed-end actin filament capping (GO:0051016)2.90508931
121chondrocyte development (GO:0002063)2.89852068
122cellular response to interferon-alpha (GO:0035457)2.88313769
123cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86387494
124positive regulation of mesenchymal cell proliferation (GO:0002053)2.86117419
125peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86017291
126Golgi transport vesicle coating (GO:0048200)2.85916553
127COPI coating of Golgi vesicle (GO:0048205)2.85916553
128polarized epithelial cell differentiation (GO:0030859)2.85783556
129response to fluid shear stress (GO:0034405)2.85678722
130proteoglycan biosynthetic process (GO:0030166)2.85581714
131negative regulation of axon guidance (GO:1902668)2.85075605
132regulation of collagen metabolic process (GO:0010712)2.84663256
133stress fiber assembly (GO:0043149)2.83243258
134negative regulation of smooth muscle cell migration (GO:0014912)2.82003040
135regulation of smooth muscle cell migration (GO:0014910)2.80612423
136negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80545364
137response to magnesium ion (GO:0032026)2.80401379
138positive regulation of transforming growth factor beta production (GO:0071636)2.80257783
139branch elongation of an epithelium (GO:0060602)2.79758664
140protein localization to endosome (GO:0036010)2.78352916
141lymphangiogenesis (GO:0001946)2.77920052
142negative regulation of adherens junction organization (GO:1903392)2.77550748
143negative regulation of focal adhesion assembly (GO:0051895)2.77550748
144negative regulation of cell junction assembly (GO:1901889)2.77550748
145vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76719116
146negative regulation of embryonic development (GO:0045992)2.75543382
147paraxial mesoderm development (GO:0048339)2.75400641
148hemidesmosome assembly (GO:0031581)2.75351866
149cell-substrate junction assembly (GO:0007044)2.74415178
150omega-hydroxylase P450 pathway (GO:0097267)2.74160933
151regulation of cell aging (GO:0090342)2.73470961
152actin filament depolymerization (GO:0030042)2.72834468
153negative regulation of protein localization to plasma membrane (GO:1903077)2.68240063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.60623443
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.58493258
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.19273305
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.16142132
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16690666
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.00076545
7* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.97687289
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.88617165
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82289632
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.81620666
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.77168104
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.65354725
13CJUN_26792858_Chip-Seq_BT549_Human2.61814516
14TP53_16413492_ChIP-PET_HCT116_Human2.56658069
15NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.49751676
16NRF2_20460467_ChIP-Seq_MEFs_Mouse2.49751676
17CLOCK_20551151_ChIP-Seq_293T_Human2.37555246
18* BRD4_25478319_ChIP-Seq_HGPS_Human2.34359812
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33215152
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.27941856
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.24703521
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18522994
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14089668
24TP53_18474530_ChIP-ChIP_U2OS_Human2.13946350
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11407987
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11407987
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06294803
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03875075
29SOX9_24532713_ChIP-Seq_HFSC_Mouse1.89624791
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.89020619
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.86685964
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73192014
33* TP53_20018659_ChIP-ChIP_R1E_Mouse1.68814204
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67422257
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63498563
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56020468
37SOX2_20726797_ChIP-Seq_SW620_Human1.53699218
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51155732
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.51012243
40* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49978661
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49525885
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.49429284
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.48984088
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46891576
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44470531
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42641238
47SMC3_22415368_ChIP-Seq_MEFs_Mouse1.42147975
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41522914
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40911234
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40665517
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.40558673
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40215217
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40108994
54ATF3_27146783_Chip-Seq_COLON_Human1.37837658
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35597388
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34448910
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32967918
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.28536855
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.26739579
60TP53_22127205_ChIP-Seq_IMR90_Human1.25497245
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25296505
62* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24478591
63* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24478591
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22745403
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21931085
66* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21371381
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21296025
68TP53_23651856_ChIP-Seq_MEFs_Mouse1.20254659
69* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19518652
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18898289
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15493360
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14893489
73* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12647983
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.12612731
75KLF5_25053715_ChIP-Seq_YYC3_Human1.11978917
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11262117
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10897749
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09444278
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09252409
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.09018899
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08763555
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07475982
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07162828
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06306454
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.05563553
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.05258384
87* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05072983
88TP63_23658742_ChIP-Seq_EP156T_Human1.04811520
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.03831126
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00773308
91AR_21909140_ChIP-Seq_LNCAP_Human1.00579725
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00398743
93RXR_22108803_ChIP-Seq_LS180_Human0.99433681
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.98540075
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.98540075
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98509415
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97874659
98SA1_22415368_ChIP-Seq_MEFs_Mouse0.96645613
99PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.96594922
100GBX2_23144817_ChIP-Seq_PC3_Human0.93585191
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92922900
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92711593
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92704208
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92643424
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91406622
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90198647
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88727091
108NFI_21473784_ChIP-Seq_ESCs_Mouse0.88117695
109FOXM1_23109430_ChIP-Seq_U2OS_Human0.88061902
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87854157
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87090614
112* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85132155
113PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85103253
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84267861
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84245764
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.84235995
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83919845
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83593245
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.82619013
120* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82300719
121ZNF274_21170338_ChIP-Seq_K562_Hela0.81737842
122AHR_22903824_ChIP-Seq_MCF-7_Human0.81522103
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79016160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.94537186
2MP0005503_abnormal_tendon_morphology4.34818388
3MP0005275_abnormal_skin_tensile4.31353258
4MP0003705_abnormal_hypodermis_morpholog4.20603765
5MP0010352_gastrointestinal_tract_polyps4.09826437
6MP0005623_abnormal_meninges_morphology3.61300703
7MP0003279_aneurysm3.17452724
8MP0005023_abnormal_wound_healing2.71879008
9MP0003195_calcinosis2.50991577
10MP0009384_cardiac_valve_regurgitation2.50927966
11MP0008004_abnormal_stomach_pH2.46878457
12MP0005257_abnormal_intraocular_pressure2.43996736
13MP0003091_abnormal_cell_migration2.39820045
14MP0001958_emphysema2.23569688
15MP0002060_abnormal_skin_morphology2.20771477
16MP0003950_abnormal_plasma_membrane2.17244810
17MP0003045_fibrosis2.13009745
18MP0002877_abnormal_melanocyte_morpholog2.08219688
19MP0005508_abnormal_skeleton_morphology2.08181881
20MP0003566_abnormal_cell_adhesion2.07304617
21MP0006054_spinal_hemorrhage2.01526085
22MP0001299_abnormal_eye_distance/1.94311899
23MP0003941_abnormal_skin_development1.89878474
24MP0004272_abnormal_basement_membrane1.87287555
25MP0009250_abnormal_appendicular_skeleto1.83693219
26MP0010030_abnormal_orbit_morphology1.81512418
27MP0003283_abnormal_digestive_organ1.80490967
28MP0002168_other_aberrant_phenotype1.74891288
29MP0001348_abnormal_lacrimal_gland1.73193267
30MP0003385_abnormal_body_wall1.68826226
31* MP0002896_abnormal_bone_mineralization1.66651865
32MP0000733_abnormal_muscle_development1.63695085
33MP0010386_abnormal_urinary_bladder1.57648168
34MP0002295_abnormal_pulmonary_circulatio1.50435216
35MP0009053_abnormal_anal_canal1.49446538
36MP0000428_abnormal_craniofacial_morphol1.48999412
37MP0001243_abnormal_dermal_layer1.47375292
38MP0005076_abnormal_cell_differentiation1.44658475
39MP0005595_abnormal_vascular_smooth1.42025704
40MP0009278_abnormal_bone_marrow1.34980172
41MP0000751_myopathy1.21681775
42MP0005390_skeleton_phenotype1.19748985
43MP0004134_abnormal_chest_morphology1.19587991
44MP0003755_abnormal_palate_morphology1.17313721
45MP0002282_abnormal_trachea_morphology1.15220508
46MP0003303_peritoneal_inflammation1.15077287
47MP0002933_joint_inflammation1.12430242
48MP0002108_abnormal_muscle_morphology1.11123614
49MP0003448_altered_tumor_morphology1.09745954
50* MP0003942_abnormal_urinary_system1.09160869
51* MP0002115_abnormal_skeleton_extremities1.08996265
52MP0000163_abnormal_cartilage_morphology1.07927492
53MP0000767_abnormal_smooth_muscle1.06966242
54MP0004808_abnormal_hematopoietic_stem1.06003201
55MP0004858_abnormal_nervous_system1.05784889
56MP0000013_abnormal_adipose_tissue1.05013528
57MP0002254_reproductive_system_inflammat1.03241345
58* MP0002113_abnormal_skeleton_development1.01846688
59MP0010368_abnormal_lymphatic_system1.00013806
60MP0000049_abnormal_middle_ear0.99822561
61MP0000762_abnormal_tongue_morphology0.98930645
62MP0000750_abnormal_muscle_regeneration0.97176177
63MP0003300_gastrointestinal_ulcer0.96574929
64MP0000432_abnormal_head_morphology0.95538324
65MP0003453_abnormal_keratinocyte_physiol0.93459985
66* MP0003937_abnormal_limbs/digits/tail_de0.91964469
67MP0010234_abnormal_vibrissa_follicle0.91599698
68MP0002177_abnormal_outer_ear0.91428858
69MP0010771_integument_phenotype0.90800384
70MP0003115_abnormal_respiratory_system0.88861291
71MP0005164_abnormal_response_to0.88741453
72MP0005395_other_phenotype0.88504920
73MP0000759_abnormal_skeletal_muscle0.88284362
74* MP0000534_abnormal_ureter_morphology0.87957969
75MP0005171_absent_coat_pigmentation0.87839623
76MP0002998_abnormal_bone_remodeling0.87788965
77MP0001542_abnormal_bone_strength0.87563450
78MP0002932_abnormal_joint_morphology0.87407829
79MP0002089_abnormal_postnatal_growth/wei0.83400641
80MP0001879_abnormal_lymphatic_vessel0.82138643
81MP0003935_abnormal_craniofacial_develop0.81139668
82MP0000467_abnormal_esophagus_morphology0.81042517
83MP0005197_abnormal_uvea_morphology0.80940407
84* MP0003795_abnormal_bone_structure0.78692186
85MP0002697_abnormal_eye_size0.76786931
86MP0002128_abnormal_blood_circulation0.76339469
87MP0000749_muscle_degeneration0.74905489
88MP0002234_abnormal_pharynx_morphology0.74608446
89MP0002233_abnormal_nose_morphology0.74251201
90MP0002116_abnormal_craniofacial_bone0.73731192
91MP0009780_abnormal_chondrocyte_physiolo0.73024923
92MP0001727_abnormal_embryo_implantation0.72856109
93MP0001177_atelectasis0.72549579
94MP0002133_abnormal_respiratory_system0.72490834
95MP0005388_respiratory_system_phenotype0.72490834
96MP0000537_abnormal_urethra_morphology0.72329386
97MP0000003_abnormal_adipose_tissue0.72269420
98MP0004947_skin_inflammation0.71963398
99MP0001533_abnormal_skeleton_physiology0.71711955
100* MP0002109_abnormal_limb_morphology0.70193896
101MP0001340_abnormal_eyelid_morphology0.69078566
102MP0000627_abnormal_mammary_gland0.68453793
103MP0002796_impaired_skin_barrier0.68088165
104MP0005501_abnormal_skin_physiology0.67891980
105MP0001849_ear_inflammation0.67403547
106MP0002925_abnormal_cardiovascular_devel0.66837493
107MP0001216_abnormal_epidermal_layer0.66195928
108MP0008007_abnormal_cellular_replicative0.66040312
109MP0000538_abnormal_urinary_bladder0.65855768
110MP0000569_abnormal_digit_pigmentation0.65040109
111MP0002111_abnormal_tail_morphology0.64784894
112MP0005165_increased_susceptibility_to0.63777565
113MP0001614_abnormal_blood_vessel0.63327131
114MP0000343_altered_response_to0.63225801
115MP0009840_abnormal_foam_cell0.62732368
116MP0004197_abnormal_fetal_growth/weight/0.61652826
117MP0002114_abnormal_axial_skeleton0.60861532
118MP0002092_abnormal_eye_morphology0.60598334
119MP0003191_abnormal_cellular_cholesterol0.59099583
120MP0006082_CNS_inflammation0.57215059
121* MP0001175_abnormal_lung_morphology0.56630060
122MP0004883_abnormal_blood_vessel0.52526199
123MP0005193_abnormal_anterior_eye0.52270326
124MP0004510_myositis0.50644733
125MP0004084_abnormal_cardiac_muscle0.48856421
126MP0005620_abnormal_muscle_contractility0.47166552
127MP0000462_abnormal_digestive_system0.47069710
128MP0001270_distended_abdomen0.46955650
129MP0001915_intracranial_hemorrhage0.46612415
130MP0005058_abnormal_lysosome_morphology0.45438689

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.66704504
2Premature rupture of membranes (HP:0001788)7.35083487
3Shallow orbits (HP:0000586)4.96717630
4Peritonitis (HP:0002586)4.69017669
5Cervical subluxation (HP:0003308)4.62369975
6Atrophic scars (HP:0001075)4.24027822
7Ankle contracture (HP:0006466)4.05336280
8Aortic dissection (HP:0002647)3.82883759
9Broad metatarsal (HP:0001783)3.70806315
10Syringomyelia (HP:0003396)3.65912815
11Spinal cord lesions (HP:0100561)3.65912815
12Dilatation of the ascending aorta (HP:0005111)3.62584642
13Abnormality of dentin (HP:0010299)3.61533753
14Soft skin (HP:0000977)3.59334645
15Spondylolisthesis (HP:0003302)3.58361796
16Fragile skin (HP:0001030)3.56849327
17Genu recurvatum (HP:0002816)3.51477343
18Neonatal short-limb short stature (HP:0008921)3.50991456
19Vertebral compression fractures (HP:0002953)3.41999542
20Cerebral aneurysm (HP:0004944)3.36027094
21Bladder diverticulum (HP:0000015)3.30146051
22Coronal craniosynostosis (HP:0004440)3.27392639
23Wormian bones (HP:0002645)3.21909726
24Aortic regurgitation (HP:0001659)3.16221576
25Wrist flexion contracture (HP:0001239)3.11363801
26Aortic aneurysm (HP:0004942)2.97588247
27Blue sclerae (HP:0000592)2.95984580
28Hypoventilation (HP:0002791)2.95503058
29Mitral valve prolapse (HP:0001634)2.92144174
30Biconcave vertebral bodies (HP:0004586)2.86031577
31Mildly elevated creatine phosphokinase (HP:0008180)2.84460097
32Increased variability in muscle fiber diameter (HP:0003557)2.82785675
33Ulnar bowing (HP:0003031)2.76707709
34Aortic valve stenosis (HP:0001650)2.65370970
35Bowel diverticulosis (HP:0005222)2.64711487
36Deviation of the hallux (HP:0010051)2.64481428
37Mesomelia (HP:0003027)2.64301567
38Buphthalmos (HP:0000557)2.61128785
39Hyperextensible skin (HP:0000974)2.56989571
40Elbow flexion contracture (HP:0002987)2.53612365
41Joint stiffness (HP:0001387)2.53354841
42Infantile muscular hypotonia (HP:0008947)2.50599595
43Hallux valgus (HP:0001822)2.49327041
44Short nail (HP:0001799)2.48931551
45Tibial bowing (HP:0002982)2.47270662
46Mild short stature (HP:0003502)2.44003115
47Spinal rigidity (HP:0003306)2.43219455
48Vascular tortuosity (HP:0004948)2.39864348
49Ovoid vertebral bodies (HP:0003300)2.39362785
50Abnormality of skeletal muscle fiber size (HP:0012084)2.38787113
51Abnormal delivery (HP:0001787)2.38733297
52Increased connective tissue (HP:0009025)2.37947605
53Distal lower limb amyotrophy (HP:0008944)2.37574254
54Bell-shaped thorax (HP:0001591)2.35418991
55Spinal cord compression (HP:0002176)2.34938528
56Osteolytic defects of the hand bones (HP:0009699)2.34564437
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.34564437
58Nonimmune hydrops fetalis (HP:0001790)2.33726849
59Increased density of long bones (HP:0006392)2.29392627
60Radial bowing (HP:0002986)2.29022179
61Bowed forearm bones (HP:0003956)2.27852060
62Bowing of the arm (HP:0006488)2.27852060
63Wide anterior fontanel (HP:0000260)2.26211971
64Microglossia (HP:0000171)2.23085520
65Follicular hyperkeratosis (HP:0007502)2.22898405
66Delayed closure of the anterior fontanelle (HP:0001476)2.22237386
67Round ear (HP:0100830)2.21601309
68Flared iliac wings (HP:0002869)2.21096567
69Abnormality of the acetabulum (HP:0003170)2.19841536
70Mitral stenosis (HP:0001718)2.17968450
71Thin bony cortex (HP:0002753)2.17435608
72Congenital glaucoma (HP:0001087)2.17330926
73Femoral bowing (HP:0002980)2.16488855
74Camptodactyly of toe (HP:0001836)2.15731572
75Distal upper limb amyotrophy (HP:0007149)2.15448661
76Upper limb amyotrophy (HP:0009129)2.15448661
77Aneurysm (HP:0002617)2.15051765
78Broad ribs (HP:0000885)2.12652337
79Disproportionate tall stature (HP:0001519)2.12335235
80Generalized amyotrophy (HP:0003700)2.11310818
81Abnormality of the peritoneum (HP:0002585)2.11143953
82Morphological abnormality of the middle ear (HP:0008609)2.09765408
83Knee flexion contracture (HP:0006380)2.07834220
84Mitral regurgitation (HP:0001653)2.05957708
85Redundant skin (HP:0001582)2.05184821
86Scapular winging (HP:0003691)2.03908695
87Asymmetry of the thorax (HP:0001555)2.02725821
88Breech presentation (HP:0001623)2.01898322
89Limb-girdle muscle weakness (HP:0003325)1.99887741
90Broad long bones (HP:0005622)1.98840468
91Overgrowth (HP:0001548)1.98160253
92Abnormality of skull ossification (HP:0002703)1.95499140
93Arterial tortuosity (HP:0005116)1.95457082
94Coxa vara (HP:0002812)1.94474826
95Cupped ribs (HP:0000887)1.92171381
96Type 1 muscle fiber predominance (HP:0003803)1.91965969
97Aplasia involving bones of the extremities (HP:0009825)1.90621050
98Aplasia involving bones of the upper limbs (HP:0009823)1.90621050
99Aplasia of the phalanges of the hand (HP:0009802)1.90621050
100Inguinal hernia (HP:0000023)1.90383757
101Thoracolumbar scoliosis (HP:0002944)1.90307156
102Tarsal synostosis (HP:0008368)1.89949082
103Delayed cranial suture closure (HP:0000270)1.89750787
104Achilles tendon contracture (HP:0001771)1.89310695
105Venous abnormality (HP:0002624)1.89162823
106Protruding ear (HP:0000411)1.88781732
107Lower limb amyotrophy (HP:0007210)1.88377997
108Osteoarthritis (HP:0002758)1.86494358
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83463295
110Short 4th metacarpal (HP:0010044)1.83463295
111Persistence of primary teeth (HP:0006335)1.82863000
112Flat cornea (HP:0007720)1.82063439
113Renal duplication (HP:0000075)1.81965395
114Cardiovascular calcification (HP:0011915)1.81410538
115Joint laxity (HP:0001388)1.81212633
116Natal tooth (HP:0000695)1.80806439
117Turricephaly (HP:0000262)1.79835647
118Ectopia lentis (HP:0001083)1.79523506
119Rectal prolapse (HP:0002035)1.78994276
120Absent frontal sinuses (HP:0002688)1.77919291
121Selective tooth agenesis (HP:0001592)1.77814613
122Abnormality of the 2nd finger (HP:0004100)1.77205882
123Decreased skull ossification (HP:0004331)1.75121792
124Abnormality of oral frenula (HP:0000190)1.74887376
125Emphysema (HP:0002097)1.74578353
126Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74076736
127Slender build (HP:0001533)1.73834837
128Bronchomalacia (HP:0002780)1.72314577
129Abnormality of the calcaneus (HP:0008364)1.71305372
130Broad face (HP:0000283)1.71076897
131Short hallux (HP:0010109)1.69165477
132Long toe (HP:0010511)1.68531119
133Joint contractures involving the joints of the feet (HP:0100492)1.68272693
134Stridor (HP:0010307)1.66819835
135Cutaneous melanoma (HP:0012056)1.66294667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.96753255
2MYLK5.22703360
3PDGFRA4.74757190
4TTN4.27014591
5LATS13.86133512
6LATS22.90575226
7AKT32.90501015
8TRIB32.75799988
9PKN22.67049256
10TGFBR22.28190307
11PAK22.27535035
12PAK32.14671635
13GRK72.02723836
14ERN11.97448432
15LRRK21.95459241
16BMX1.93746616
17EPHB21.91941866
18EEF2K1.91905598
19STK31.89803077
20TRPM71.82736565
21PDGFRB1.73855070
22FER1.69786750
23FGFR11.64045750
24PTK21.54473239
25RIPK11.54396478
26PLK21.54370758
27SIK11.42036538
28EPHA31.39658022
29MOS1.38074894
30TAOK21.32431604
31PAK41.29478387
32RPS6KA41.28957066
33MET1.24158061
34PRKD21.14060096
35SCYL21.12195995
36PTK61.10548550
37NEK91.08944262
38PTK2B1.08500099
39NTRK11.06748959
40FRK0.99742715
41ADRBK20.98205277
42ABL20.95634715
43CDK60.92352975
44MAPK70.89583867
45TESK10.88621295
46DMPK0.88487468
47MAP2K30.85321509
48PRKCH0.84479573
49MTOR0.83490007
50DAPK30.83395243
51WNK10.82355591
52MELK0.82114613
53RPS6KA20.81632253
54ERBB40.81037637
55GRK50.80784608
56ERBB30.80339220
57EPHA20.80032739
58LIMK10.79081406
59PIK3CA0.75910829
60TAOK10.75145834
61MST1R0.72573444
62STK38L0.72087047
63ROCK10.71822932
64EPHB10.71420611
65GRK10.69532660
66MAPKAPK50.68780439
67MAP2K10.68493872
68MAP3K60.68418310
69INSR0.66912486
70FLT30.66832559
71FGFR20.63920916
72ROCK20.61096601
73TGFBR10.59980391
74GSK3A0.59158641
75PLK30.59095731
76RET0.59067737
77CAMKK10.58956937
78MAP3K80.58649810
79JAK30.57716543
80CDK120.57522896
81IRAK30.57290273
82ICK0.54651608
83ADRBK10.53363181
84PAK60.52671278
85STK100.50970030
86CDK80.50438635
87DYRK1B0.48425773
88CDK150.45370974
89CDK140.45197019
90MAP3K100.44842578
91KIT0.44323577
92PIM20.44278759
93ALK0.44236094
94TYK20.44224643
95PRKD10.42397791
96SRC0.42366724
97MKNK10.42247633
98PRPF4B0.41880193
99CAMK2G0.41720648
100RPS6KC10.41158963
101RPS6KL10.41158963
102FGFR30.41032542
103CLK10.40516037
104CDK180.40252294
105CDC42BPA0.37534023
106JAK10.37351602
107NUAK10.36462388
108ILK0.36243686
109PASK0.35616783
110CDK11A0.34943006
111PRKD30.34594407
112PRKG20.34235403
113MAPKAPK20.33308785
114ABL10.32834676
115NEK20.32733903
116RPS6KA60.32236859
117CAMK1D0.32036146
118PAK10.31746318
119TTK0.30605051
120HIPK20.29354360
121TBK10.29271132
122PIK3CG0.29247543
123MAPK10.29120778
124CAMKK20.29001721
125MARK10.27965767
126MAP3K30.27842434
127MAPK40.27716638
128KSR20.27507556
129FYN0.26636372
130MAPKAPK30.26522691
131PRKCE0.26362061
132ZAP700.26284225
133MAPK110.25626373
134PNCK0.25573059
135STK380.25181107
136TEC0.20745370
137MAP3K140.20644597

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.95565454
2Focal adhesion_Homo sapiens_hsa045102.86509491
3Bladder cancer_Homo sapiens_hsa052192.69173138
4Proteoglycans in cancer_Homo sapiens_hsa052052.59109824
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49541227
6MicroRNAs in cancer_Homo sapiens_hsa052062.37307436
7Malaria_Homo sapiens_hsa051442.31663353
8Melanoma_Homo sapiens_hsa052182.24088991
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95267903
10Small cell lung cancer_Homo sapiens_hsa052221.93677652
11Amoebiasis_Homo sapiens_hsa051461.87313485
12TGF-beta signaling pathway_Homo sapiens_hsa043501.87199276
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.85081191
14Adherens junction_Homo sapiens_hsa045201.82380834
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79730049
16p53 signaling pathway_Homo sapiens_hsa041151.74607882
17Glioma_Homo sapiens_hsa052141.73767788
18Chronic myeloid leukemia_Homo sapiens_hsa052201.73372126
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66936935
20Hippo signaling pathway_Homo sapiens_hsa043901.62211215
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60086222
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52641845
23Dilated cardiomyopathy_Homo sapiens_hsa054141.50548007
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.50299172
25TNF signaling pathway_Homo sapiens_hsa046681.48671245
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46158538
27Protein digestion and absorption_Homo sapiens_hsa049741.43061996
28Other glycan degradation_Homo sapiens_hsa005111.41821235
29Axon guidance_Homo sapiens_hsa043601.38408205
30Shigellosis_Homo sapiens_hsa051311.35878932
31Hedgehog signaling pathway_Homo sapiens_hsa043401.28391125
32Basal cell carcinoma_Homo sapiens_hsa052171.26422411
33Rap1 signaling pathway_Homo sapiens_hsa040151.24926046
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22814771
35Ovarian steroidogenesis_Homo sapiens_hsa049131.22668798
36Phagosome_Homo sapiens_hsa041451.18996964
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.18662216
38Prostate cancer_Homo sapiens_hsa052151.17623372
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.15687725
40Pancreatic cancer_Homo sapiens_hsa052121.15497659
41Pathways in cancer_Homo sapiens_hsa052001.14407596
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09002269
43Gap junction_Homo sapiens_hsa045401.06215390
44Platelet activation_Homo sapiens_hsa046111.05854077
45VEGF signaling pathway_Homo sapiens_hsa043701.05844964
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04572995
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02935057
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98691020
49ErbB signaling pathway_Homo sapiens_hsa040120.98580837
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95779558
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95475505
52Leishmaniasis_Homo sapiens_hsa051400.94302399
53Prion diseases_Homo sapiens_hsa050200.93085737
54Salmonella infection_Homo sapiens_hsa051320.91761930
55GnRH signaling pathway_Homo sapiens_hsa049120.90004396
56HTLV-I infection_Homo sapiens_hsa051660.90000773
57Tight junction_Homo sapiens_hsa045300.88342588
58Vibrio cholerae infection_Homo sapiens_hsa051100.84131463
59Wnt signaling pathway_Homo sapiens_hsa043100.83985670
60Sulfur metabolism_Homo sapiens_hsa009200.83107901
61Renal cell carcinoma_Homo sapiens_hsa052110.82761428
62Cocaine addiction_Homo sapiens_hsa050300.81965991
63Estrogen signaling pathway_Homo sapiens_hsa049150.81569618
64Ras signaling pathway_Homo sapiens_hsa040140.80639972
65HIF-1 signaling pathway_Homo sapiens_hsa040660.77435787
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77294364
67Viral carcinogenesis_Homo sapiens_hsa052030.73243904
68Melanogenesis_Homo sapiens_hsa049160.73042135
69mTOR signaling pathway_Homo sapiens_hsa041500.71412936
70Hepatitis B_Homo sapiens_hsa051610.71386635
71One carbon pool by folate_Homo sapiens_hsa006700.70857586
72Toxoplasmosis_Homo sapiens_hsa051450.69402460
73Viral myocarditis_Homo sapiens_hsa054160.68247933
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.67050689
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66931121
76Rheumatoid arthritis_Homo sapiens_hsa053230.64678680
77Non-small cell lung cancer_Homo sapiens_hsa052230.63356026
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62260987
79MAPK signaling pathway_Homo sapiens_hsa040100.62105748
80Oxytocin signaling pathway_Homo sapiens_hsa049210.61169847
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.60881926
82Caffeine metabolism_Homo sapiens_hsa002320.60683889
83Dorso-ventral axis formation_Homo sapiens_hsa043200.60103101
84Cell cycle_Homo sapiens_hsa041100.58187866
85Calcium signaling pathway_Homo sapiens_hsa040200.57648905
86cAMP signaling pathway_Homo sapiens_hsa040240.57347954
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57056804
88African trypanosomiasis_Homo sapiens_hsa051430.56351778
89Sphingolipid metabolism_Homo sapiens_hsa006000.55902784
90Pertussis_Homo sapiens_hsa051330.54454476
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53590384
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.53295481
93Endocytosis_Homo sapiens_hsa041440.53164663
94Complement and coagulation cascades_Homo sapiens_hsa046100.52580085
95Tuberculosis_Homo sapiens_hsa051520.51103814
96Renin-angiotensin system_Homo sapiens_hsa046140.50293733
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.50152367
98Colorectal cancer_Homo sapiens_hsa052100.49322953
99Cholinergic synapse_Homo sapiens_hsa047250.49187239
100Apoptosis_Homo sapiens_hsa042100.47143063
101Endometrial cancer_Homo sapiens_hsa052130.46123592
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46014150
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45373611
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43459823
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42808751
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42518775
107Lysosome_Homo sapiens_hsa041420.41820449
108Thyroid hormone synthesis_Homo sapiens_hsa049180.41244388
109N-Glycan biosynthesis_Homo sapiens_hsa005100.40701429
110Hepatitis C_Homo sapiens_hsa051600.39948005
111FoxO signaling pathway_Homo sapiens_hsa040680.39228481
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.38642451
113Gastric acid secretion_Homo sapiens_hsa049710.37892461
114Osteoclast differentiation_Homo sapiens_hsa043800.37600512
115Long-term depression_Homo sapiens_hsa047300.37184872
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36872696
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.34918383
118Prolactin signaling pathway_Homo sapiens_hsa049170.33746391
119Choline metabolism in cancer_Homo sapiens_hsa052310.33197018
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32723152
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31625411

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