GREM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.97258669
2negative regulation of fibrinolysis (GO:0051918)5.44567894
3collagen fibril organization (GO:0030199)4.71787502
4mesenchymal-epithelial cell signaling (GO:0060638)4.64363254
5urinary tract smooth muscle contraction (GO:0014848)4.45207717
6behavioral response to nicotine (GO:0035095)4.35622357
7virion attachment to host cell (GO:0019062)4.33018020
8adhesion of symbiont to host cell (GO:0044650)4.33018020
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.31896668
10regulation of fibrinolysis (GO:0051917)4.22739986
11wound healing, spreading of epidermal cells (GO:0035313)4.18316044
12regulation of plasminogen activation (GO:0010755)4.06829735
13cell adhesion mediated by integrin (GO:0033627)4.03678068
14type B pancreatic cell proliferation (GO:0044342)3.99723836
15peristalsis (GO:0030432)3.95401576
16negative regulation of leukocyte chemotaxis (GO:0002689)3.90665095
17endodermal cell differentiation (GO:0035987)3.89370487
18positive regulation of fibroblast migration (GO:0010763)3.88515026
19bone trabecula formation (GO:0060346)3.86337919
20protein heterotrimerization (GO:0070208)3.80002998
21pyrimidine nucleobase catabolic process (GO:0006208)3.76636513
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.73402015
23axon extension involved in axon guidance (GO:0048846)3.73402015
24negative regulation of fatty acid transport (GO:2000192)3.71510766
25axonal fasciculation (GO:0007413)3.67563839
26* sequestering of extracellular ligand from receptor (GO:0035581)3.66388388
27skin morphogenesis (GO:0043589)3.66004138
28positive regulation of endothelial cell apoptotic process (GO:2000353)3.62858952
29dermatan sulfate biosynthetic process (GO:0030208)3.56123056
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55644027
31epoxygenase P450 pathway (GO:0019373)3.55491560
32regulation of tight junction assembly (GO:2000810)3.50919031
33craniofacial suture morphogenesis (GO:0097094)3.49142103
34positive regulation of gastrulation (GO:2000543)3.48149655
35adhesion of symbiont to host (GO:0044406)3.37743925
36neuron recognition (GO:0008038)3.35599342
37wound healing, spreading of cells (GO:0044319)3.25603873
38apoptotic cell clearance (GO:0043277)3.25356757
39positive regulation of cardiac muscle cell differentiation (GO:2000727)3.16949287
40dermatan sulfate metabolic process (GO:0030205)3.14999977
41parturition (GO:0007567)3.12852689
42nucleobase catabolic process (GO:0046113)3.12050368
43regulation of chemokine-mediated signaling pathway (GO:0070099)3.06569127
44cell migration involved in heart development (GO:0060973)3.06563165
45cellular response to vitamin (GO:0071295)3.06541481
46cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.04704054
47negative regulation of axon guidance (GO:1902668)3.01040539
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99558384
49protein localization to cell surface (GO:0034394)2.98221498
50negative regulation of axon extension involved in axon guidance (GO:0048843)2.97716209
51stress fiber assembly (GO:0043149)2.94621422
52protein retention in ER lumen (GO:0006621)2.92824638
53cellular response to vitamin D (GO:0071305)2.91906233
54peptidyl-proline hydroxylation (GO:0019511)2.89019279
55protein targeting to plasma membrane (GO:0072661)2.88948447
56cell migration involved in sprouting angiogenesis (GO:0002042)2.88212197
57positive regulation of macrophage activation (GO:0043032)2.86348370
58substrate-independent telencephalic tangential migration (GO:0021826)2.85990999
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.85990999
60plasma membrane repair (GO:0001778)2.84621400
61positive regulation of blood coagulation (GO:0030194)2.82098421
62positive regulation of hemostasis (GO:1900048)2.82098421
63peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.80829843
64extracellular fibril organization (GO:0043206)2.80431106
65endocardial cushion development (GO:0003197)2.76491479
66fibrinolysis (GO:0042730)2.76399229
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.74209153
68regulation of synapse structural plasticity (GO:0051823)2.73198293
69fibril organization (GO:0097435)2.72731596
70collagen metabolic process (GO:0032963)2.70448436
71regulation of axon guidance (GO:1902667)2.70140115
72activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.68155498
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67824646
74platelet degranulation (GO:0002576)2.67155140
75extracellular matrix assembly (GO:0085029)2.67016666
76tachykinin receptor signaling pathway (GO:0007217)2.65603500
77synaptic vesicle docking involved in exocytosis (GO:0016081)2.65568501
78negative chemotaxis (GO:0050919)2.64921534
79negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.64829835
80positive regulation of axon extension (GO:0045773)2.64475381
81neuronal ion channel clustering (GO:0045161)2.64059798
82regulation of axon extension involved in axon guidance (GO:0048841)2.64025461
83positive regulation of catecholamine secretion (GO:0033605)2.63914946
84presynaptic membrane organization (GO:0097090)2.63863971
85neurofilament cytoskeleton organization (GO:0060052)2.63466845
86peptidyl-glutamic acid carboxylation (GO:0017187)2.63132639
87protein carboxylation (GO:0018214)2.63132639
88inner ear receptor cell development (GO:0060119)2.62677818
89regulation of cardiac muscle cell differentiation (GO:2000725)2.59824611
90chondrocyte development (GO:0002063)2.59126428
91* extracellular negative regulation of signal transduction (GO:1900116)2.57881055
92* extracellular regulation of signal transduction (GO:1900115)2.57881055
93blood vessel maturation (GO:0001955)2.57616880
94collagen catabolic process (GO:0030574)2.57307406
95metanephric mesenchyme development (GO:0072075)2.56868107
96multicellular organismal macromolecule metabolic process (GO:0044259)2.56195726
97negative regulation of adherens junction organization (GO:1903392)2.56141117
98negative regulation of focal adhesion assembly (GO:0051895)2.56141117
99negative regulation of cell junction assembly (GO:1901889)2.56141117
100cranial suture morphogenesis (GO:0060363)2.55816024
101negative regulation of smooth muscle cell migration (GO:0014912)2.55405053
102axon extension (GO:0048675)2.53530701
103actin filament depolymerization (GO:0030042)2.51839708
104substrate-dependent cell migration (GO:0006929)2.51339095
105neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50303199
106ganglion development (GO:0061548)2.49573309
107positive regulation of coagulation (GO:0050820)2.49491498
108neuromuscular synaptic transmission (GO:0007274)2.49167788
109cellular response to interferon-alpha (GO:0035457)2.48134649
110exploration behavior (GO:0035640)2.46999155
111protein hydroxylation (GO:0018126)2.45556064
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.45509440
113positive regulation of fatty acid biosynthetic process (GO:0045723)2.45462873
114cerebellar Purkinje cell layer development (GO:0021680)2.45194998
115tooth mineralization (GO:0034505)2.45174861
116central nervous system projection neuron axonogenesis (GO:0021952)2.44953310
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44816583
118cell migration in hindbrain (GO:0021535)2.43530769
119multicellular organismal metabolic process (GO:0044236)2.43284826
120innervation (GO:0060384)2.42659848
121heparan sulfate proteoglycan metabolic process (GO:0030201)2.42066251
122phasic smooth muscle contraction (GO:0014821)2.41234159
123protein localization to synapse (GO:0035418)2.40922664
124blood vessel endothelial cell migration (GO:0043534)2.40912098
125smooth muscle contraction (GO:0006939)2.40409440
126behavioral response to ethanol (GO:0048149)2.39984887
127Golgi transport vesicle coating (GO:0048200)2.39536164
128COPI coating of Golgi vesicle (GO:0048205)2.39536164
129basement membrane organization (GO:0071711)2.37607459
130adrenal gland development (GO:0030325)2.37037540
131extracellular matrix disassembly (GO:0022617)2.36935601
132positive regulation of fatty acid beta-oxidation (GO:0032000)2.36668295
133positive regulation of vesicle fusion (GO:0031340)2.36188329
134receptor recycling (GO:0001881)2.35611586
135multicellular organismal catabolic process (GO:0044243)2.34724738
136negative regulation of chemotaxis (GO:0050922)2.34281406
137short-term memory (GO:0007614)2.33748838
138positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.33483010
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.32592199
140regulation of axon extension (GO:0030516)2.32146225
141smooth muscle tissue development (GO:0048745)2.32118995
142synaptic vesicle maturation (GO:0016188)2.30358507
143dendritic spine morphogenesis (GO:0060997)2.29825133
144cellular response to nutrient (GO:0031670)2.29078799
145low-density lipoprotein particle clearance (GO:0034383)2.28925002
146locomotory exploration behavior (GO:0035641)2.28645439
147glutamate secretion (GO:0014047)2.28173083
148behavioral response to pain (GO:0048266)2.28060917
149kidney mesenchyme development (GO:0072074)2.27453828
150postsynaptic membrane organization (GO:0001941)2.25901492
151left/right pattern formation (GO:0060972)2.25447098
152regulation of transforming growth factor beta1 production (GO:0032908)2.25375316
153wound healing (GO:0042060)2.24406132
154vascular endothelial growth factor signaling pathway (GO:0038084)2.22757239
155response to parathyroid hormone (GO:0071107)2.22350838
156regulation of short-term neuronal synaptic plasticity (GO:0048172)2.22336845
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.21375000
158substrate adhesion-dependent cell spreading (GO:0034446)2.21269327
159negative regulation of catecholamine secretion (GO:0033604)2.20987199
160midgut development (GO:0007494)2.20956529
161positive regulation of protein autophosphorylation (GO:0031954)2.20815675
162neuron projection extension (GO:1990138)2.20201569
163negative regulation of axon extension (GO:0030517)2.19119331
164positive regulation of synapse assembly (GO:0051965)2.18638393
165uterus development (GO:0060065)2.16739806
166negative regulation of behavior (GO:0048521)2.13276325
167* negative regulation of BMP signaling pathway (GO:0030514)2.13034268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.94087540
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.22549425
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.53714873
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44620309
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25819451
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24104363
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24104363
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23321120
9CLOCK_20551151_ChIP-Seq_293T_Human2.21150442
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.21130010
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18481927
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.13875124
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13244806
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.13022412
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.13022412
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.11355094
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10975962
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.07659697
19* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00703772
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93886374
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89222281
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87792379
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85698047
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85529577
25EZH2_22144423_ChIP-Seq_EOC_Human1.84895529
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84870530
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83062667
28CJUN_26792858_Chip-Seq_BT549_Human1.82682710
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.80837914
30TP53_18474530_ChIP-ChIP_U2OS_Human1.80645992
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75396040
32* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.73250224
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72715370
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.71123293
35GBX2_23144817_ChIP-Seq_PC3_Human1.66459639
36TP53_16413492_ChIP-PET_HCT116_Human1.66111710
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.64827615
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64638887
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63048566
40* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60336492
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58019320
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57856311
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.53664124
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51046093
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49320980
46DROSHA_22980978_ChIP-Seq_HELA_Human1.49042565
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48368565
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.48289054
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.47562528
50REST_21632747_ChIP-Seq_MESCs_Mouse1.42581068
51* LXR_22158963_ChIP-Seq_LIVER_Mouse1.42449238
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41024728
53IGF1R_20145208_ChIP-Seq_DFB_Human1.38491100
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38025423
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37152997
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36396854
57AR_21572438_ChIP-Seq_LNCaP_Human1.35064139
58RNF2_27304074_Chip-Seq_NSC_Mouse1.33100650
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32120541
60ZNF274_21170338_ChIP-Seq_K562_Hela1.29515727
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29304690
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29239075
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.28568690
64RXR_22108803_ChIP-Seq_LS180_Human1.26066653
65P300_19829295_ChIP-Seq_ESCs_Human1.24709102
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23007538
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21464136
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20803246
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20435280
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.20418674
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.19873060
72* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19856395
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19757970
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19641977
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19111744
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18818636
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18527193
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18123584
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.17771045
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17764710
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17256041
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17008878
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16680358
84* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16224726
85* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13146947
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13028341
87BCAT_22108803_ChIP-Seq_LS180_Human1.12888809
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.11997367
89SOX2_20726797_ChIP-Seq_SW620_Human1.11996502
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11903308
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11669668
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11247278
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11193114
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11060619
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10376674
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10292745
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.09139514
98* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08904741
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08751657
100AR_25329375_ChIP-Seq_VCAP_Human1.08257696
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06696124
102* P53_22387025_ChIP-Seq_ESCs_Mouse1.04248340
103* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03860531
104SMAD4_21799915_ChIP-Seq_A2780_Human1.03564553
105TP53_23651856_ChIP-Seq_MEFs_Mouse1.03014826
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02660666
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.02333946
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02037773
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00854384
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00798203
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00715682
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00607473
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99654036
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99023040
115* JUN_21703547_ChIP-Seq_K562_Human0.98909922
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98218699
117TP53_22127205_ChIP-Seq_IMR90_Human0.98153755
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97857133
119* NFE2_27457419_Chip-Seq_LIVER_Mouse0.97801009
120* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97551791
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95941144
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95466266
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95420891
124* EZH2_27294783_Chip-Seq_NPCs_Mouse0.95334556
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95316963
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.95144449
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94718439
128* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94697203
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94632277
130VDR_22108803_ChIP-Seq_LS180_Human0.92862510
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92564667
132STAT3_23295773_ChIP-Seq_U87_Human0.92413698
133AHR_22903824_ChIP-Seq_MCF-7_Human0.92207564
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.92150791
135ISL1_27105846_Chip-Seq_CPCs_Mouse0.91659332
136* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91080905
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.90339095
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.90146327
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88928097
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88928097
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88899751
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.88893345
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.88460595
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88198941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.85612302
2MP0005503_abnormal_tendon_morphology4.55347166
3MP0003705_abnormal_hypodermis_morpholog4.43282621
4MP0005275_abnormal_skin_tensile4.18889775
5MP0003279_aneurysm3.86821670
6MP0001958_emphysema2.99275841
7MP0009384_cardiac_valve_regurgitation2.69326514
8MP0005623_abnormal_meninges_morphology2.57681555
9MP0003880_abnormal_central_pattern2.57098735
10MP0004272_abnormal_basement_membrane2.52030559
11MP0000013_abnormal_adipose_tissue2.43573414
12MP0006276_abnormal_autonomic_nervous2.42639528
13MP0002295_abnormal_pulmonary_circulatio2.32198649
14MP0010386_abnormal_urinary_bladder2.25867760
15MP0003091_abnormal_cell_migration2.11098633
16MP0004859_abnormal_synaptic_plasticity2.09001365
17MP0001299_abnormal_eye_distance/2.07013313
18MP0002822_catalepsy2.00594312
19MP0010352_gastrointestinal_tract_polyps1.98961020
20MP0005023_abnormal_wound_healing1.98205840
21MP0005360_urolithiasis1.97138751
22MP0001188_hyperpigmentation1.89965575
23MP0005423_abnormal_somatic_nervous1.88439477
24MP0003566_abnormal_cell_adhesion1.87023270
25MP0001348_abnormal_lacrimal_gland1.77807617
26MP0005508_abnormal_skeleton_morphology1.75205082
27MP0004145_abnormal_muscle_electrophysio1.73780728
28MP0005257_abnormal_intraocular_pressure1.68501427
29MP0002909_abnormal_adrenal_gland1.68044483
30MP0010368_abnormal_lymphatic_system1.67852969
31MP0006054_spinal_hemorrhage1.60840848
32MP0000778_abnormal_nervous_system1.60487330
33MP0009250_abnormal_appendicular_skeleto1.57301529
34MP0001542_abnormal_bone_strength1.54172293
35MP0009053_abnormal_anal_canal1.49215111
36MP0009780_abnormal_chondrocyte_physiolo1.48174603
37MP0002139_abnormal_hepatobiliary_system1.47765943
38MP0010030_abnormal_orbit_morphology1.46888520
39MP0002896_abnormal_bone_mineralization1.46869677
40MP0003385_abnormal_body_wall1.45399880
41MP0002108_abnormal_muscle_morphology1.43616324
42MP0001243_abnormal_dermal_layer1.41981856
43MP0001177_atelectasis1.39982406
44MP0001529_abnormal_vocalization1.39098604
45MP0004270_analgesia1.38352559
46MP0002168_other_aberrant_phenotype1.35558367
47MP0002060_abnormal_skin_morphology1.32749930
48MP0002184_abnormal_innervation1.26825391
49MP0005595_abnormal_vascular_smooth1.26575524
50MP0003329_amyloid_beta_deposits1.21918263
51MP0002735_abnormal_chemical_nociception1.20197559
52MP0003045_fibrosis1.18042015
53MP0003283_abnormal_digestive_organ1.16816704
54MP0003950_abnormal_plasma_membrane1.16553350
55MP0004885_abnormal_endolymph1.16345485
56MP0002938_white_spotting1.13371947
57MP0001968_abnormal_touch/_nociception1.13280689
58MP0002272_abnormal_nervous_system1.11559937
59MP0008004_abnormal_stomach_pH1.11047740
60MP0000534_abnormal_ureter_morphology1.08492184
61MP0003942_abnormal_urinary_system1.07994468
62MP0003252_abnormal_bile_duct1.07786857
63MP0000003_abnormal_adipose_tissue1.06995969
64MP0005084_abnormal_gallbladder_morpholo1.05663444
65MP0002734_abnormal_mechanical_nocicepti1.05045751
66MP0003787_abnormal_imprinting1.02435530
67MP0005085_abnormal_gallbladder_physiolo1.01023684
68MP0004133_heterotaxia0.99088241
69MP0000163_abnormal_cartilage_morphology0.98843690
70MP0005164_abnormal_response_to0.95853876
71MP0000749_muscle_degeneration0.95396144
72MP0003635_abnormal_synaptic_transmissio0.94695822
73MP0002089_abnormal_postnatal_growth/wei0.94557408
74MP0002572_abnormal_emotion/affect_behav0.94407635
75MP0000955_abnormal_spinal_cord0.93025676
76MP0008789_abnormal_olfactory_epithelium0.92250475
77MP0003959_abnormal_lean_body0.92088360
78MP0000538_abnormal_urinary_bladder0.92009747
79MP0005365_abnormal_bile_salt0.91250077
80MP0000767_abnormal_smooth_muscle0.90753902
81MP0002837_dystrophic_cardiac_calcinosis0.90161157
82MP0002115_abnormal_skeleton_extremities0.89796486
83MP0002282_abnormal_trachea_morphology0.89758083
84MP0000230_abnormal_systemic_arterial0.89710196
85MP0003755_abnormal_palate_morphology0.89544966
86MP0004233_abnormal_muscle_weight0.89057197
87MP0003115_abnormal_respiratory_system0.88612783
88MP0001970_abnormal_pain_threshold0.88402971
89MP0002557_abnormal_social/conspecific_i0.86801870
90MP0003195_calcinosis0.86800863
91MP0005187_abnormal_penis_morphology0.86464033
92MP0005499_abnormal_olfactory_system0.85931305
93MP0005394_taste/olfaction_phenotype0.85931305
94MP0004142_abnormal_muscle_tone0.84013275
95MP0000639_abnormal_adrenal_gland0.83467077
96MP0005390_skeleton_phenotype0.83180846
97MP0002067_abnormal_sensory_capabilities0.80562110
98MP0000751_myopathy0.78891883
99MP0005386_behavior/neurological_phenoty0.78798446
100MP0004924_abnormal_behavior0.78798446
101MP0008875_abnormal_xenobiotic_pharmacok0.78478992
102MP0004134_abnormal_chest_morphology0.78336741
103MP0002882_abnormal_neuron_morphology0.78002868
104MP0000678_abnormal_parathyroid_gland0.77960794
105MP0005248_abnormal_Harderian_gland0.76392458
106MP0000750_abnormal_muscle_regeneration0.76016492
107MP0001756_abnormal_urination0.75028241
108MP0002751_abnormal_autonomic_nervous0.74931498
109MP0005083_abnormal_biliary_tract0.74741971
110MP0001440_abnormal_grooming_behavior0.73845944
111MP0002163_abnormal_gland_morphology0.73643972
112MP0005369_muscle_phenotype0.73340931
113MP0005388_respiratory_system_phenotype0.73246705
114MP0002133_abnormal_respiratory_system0.73246705
115MP0000733_abnormal_muscle_development0.72708004
116MP0003941_abnormal_skin_development0.72566090
117MP0002160_abnormal_reproductive_system0.70682165
118MP0002109_abnormal_limb_morphology0.70563018
119MP0003937_abnormal_limbs/digits/tail_de0.70364059
120MP0002128_abnormal_blood_circulation0.70204316
121MP0000759_abnormal_skeletal_muscle0.70133406
122MP0002877_abnormal_melanocyte_morpholog0.69931063
123MP0000049_abnormal_middle_ear0.69660171
124MP0005620_abnormal_muscle_contractility0.68915921
125MP0001486_abnormal_startle_reflex0.68618206
126MP0002733_abnormal_thermal_nociception0.67945311
127MP0000569_abnormal_digit_pigmentation0.67533117
128MP0001984_abnormal_olfaction0.67173236
129MP0008775_abnormal_heart_ventricle0.67100549
130MP0004883_abnormal_blood_vessel0.66755352
131MP0002063_abnormal_learning/memory/cond0.65809936
132MP0001905_abnormal_dopamine_level0.65682950
133MP0004811_abnormal_neuron_physiology0.65592984
134MP0002932_abnormal_joint_morphology0.65459672
135MP0002752_abnormal_somatic_nervous0.65040056
136MP0002113_abnormal_skeleton_development0.64183922
137MP0010234_abnormal_vibrissa_follicle0.63272122
138MP0000428_abnormal_craniofacial_morphol0.62577663
139MP0006138_congestive_heart_failure0.60947507
140MP0004858_abnormal_nervous_system0.60681508
141MP0009745_abnormal_behavioral_response0.59073272
142MP0010329_abnormal_lipoprotein_level0.58224344
143MP0001340_abnormal_eyelid_morphology0.56848933
144MP0000747_muscle_weakness0.54852965
145MP0005375_adipose_tissue_phenotype0.53972465
146MP0002177_abnormal_outer_ear0.53310169
147MP0004087_abnormal_muscle_fiber0.52956896
148MP0002064_seizures0.52867069
149MP0002998_abnormal_bone_remodeling0.52408672
150MP0005332_abnormal_amino_acid0.51843753
151MP0000604_amyloidosis0.51617543
152MP0001614_abnormal_blood_vessel0.51334983
153MP0008961_abnormal_basal_metabolism0.50899582
154MP0003806_abnormal_nucleotide_metabolis0.50817490

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.65318502
2Premature rupture of membranes (HP:0001788)7.62997419
3Peritonitis (HP:0002586)5.14027594
4Aortic dissection (HP:0002647)4.64651886
5Shallow orbits (HP:0000586)4.62019235
6Aortic aneurysm (HP:0004942)4.14561308
7Dilatation of the ascending aorta (HP:0005111)4.02040434
8Atrophic scars (HP:0001075)3.96829425
9Soft skin (HP:0000977)3.89620402
10Abnormality of dentin (HP:0010299)3.88428268
11Cerebral aneurysm (HP:0004944)3.87966779
12Vertebral compression fractures (HP:0002953)3.66348898
13Biconcave vertebral bodies (HP:0004586)3.63572217
14Broad metatarsal (HP:0001783)3.56823327
15Fragile skin (HP:0001030)3.48753317
16Bladder diverticulum (HP:0000015)3.42492150
17Genu recurvatum (HP:0002816)3.34815033
18Ankle contracture (HP:0006466)3.25295371
19Cervical subluxation (HP:0003308)3.24691187
20Infantile muscular hypotonia (HP:0008947)3.22339137
21Hyperphosphatemia (HP:0002905)3.20802398
22Conjugated hyperbilirubinemia (HP:0002908)3.14256824
23Wormian bones (HP:0002645)3.11786310
24Spinal rigidity (HP:0003306)3.04808016
25Blue sclerae (HP:0000592)3.03578675
26Mitral valve prolapse (HP:0001634)2.94124931
27Aortic regurgitation (HP:0001659)2.92423233
28Deep venous thrombosis (HP:0002625)2.92125786
29Neonatal short-limb short stature (HP:0008921)2.91697285
30Overgrowth (HP:0001548)2.88057748
31Hyperextensible skin (HP:0000974)2.82749657
32Bowel diverticulosis (HP:0005222)2.81087460
33Mild short stature (HP:0003502)2.79400574
34Type 1 muscle fiber predominance (HP:0003803)2.78254819
35Thoracolumbar scoliosis (HP:0002944)2.74838074
36Increased connective tissue (HP:0009025)2.66492947
37Wrist flexion contracture (HP:0001239)2.59581429
38Cardiovascular calcification (HP:0011915)2.59441102
39Abnormal delivery (HP:0001787)2.58090454
40Torticollis (HP:0000473)2.55042766
41Coronal craniosynostosis (HP:0004440)2.52972854
42Aneurysm (HP:0002617)2.46283998
43Buphthalmos (HP:0000557)2.45143712
44Short nail (HP:0001799)2.43571847
45Metaphyseal dysplasia (HP:0100255)2.42512669
46Ectopia lentis (HP:0001083)2.42354426
47Vascular tortuosity (HP:0004948)2.41659320
48Round ear (HP:0100830)2.36406521
49Abnormality of the Achilles tendon (HP:0005109)2.35206099
50Follicular hyperkeratosis (HP:0007502)2.35132234
51Increased variability in muscle fiber diameter (HP:0003557)2.34051423
52Achilles tendon contracture (HP:0001771)2.31616443
53Aortic valve stenosis (HP:0001650)2.31587041
54Wide anterior fontanel (HP:0000260)2.30790706
55Abnormality of the acetabulum (HP:0003170)2.29696744
56Myokymia (HP:0002411)2.26990502
57Camptodactyly of toe (HP:0001836)2.26209496
58Morphological abnormality of the middle ear (HP:0008609)2.23070343
59Broad ribs (HP:0000885)2.22468784
60Congenital glaucoma (HP:0001087)2.21052369
61Distal upper limb amyotrophy (HP:0007149)2.19988030
62Upper limb amyotrophy (HP:0009129)2.19988030
63Mitral stenosis (HP:0001718)2.19585733
64Increased corneal curvature (HP:0100692)2.18562376
65Keratoconus (HP:0000563)2.18562376
66Deviation of the hallux (HP:0010051)2.16024179
67Aplasia involving bones of the extremities (HP:0009825)2.12412008
68Aplasia involving bones of the upper limbs (HP:0009823)2.12412008
69Aplasia of the phalanges of the hand (HP:0009802)2.12412008
70Hallux valgus (HP:0001822)2.11762445
71Elbow flexion contracture (HP:0002987)2.11043978
72Bronchomalacia (HP:0002780)2.09932330
73Arterial tortuosity (HP:0005116)2.09513614
74Joint stiffness (HP:0001387)2.06462479
75Slender build (HP:0001533)2.03706278
76Bell-shaped thorax (HP:0001591)2.03643023
77Tetany (HP:0001281)2.01837852
78Turricephaly (HP:0000262)2.00431687
79Bulbous nose (HP:0000414)1.99359090
80Hypoventilation (HP:0002791)1.99087332
81Flat cornea (HP:0007720)1.98341585
82Abnormality of the peritoneum (HP:0002585)1.96676469
83Ovoid vertebral bodies (HP:0003300)1.96666494
84Thin bony cortex (HP:0002753)1.95527140
85Osteopenia (HP:0000938)1.93855047
86Mildly elevated creatine phosphokinase (HP:0008180)1.92810253
87Gastrointestinal dysmotility (HP:0002579)1.91839835
88Mesomelia (HP:0003027)1.91184345
89Abnormality of skeletal muscle fiber size (HP:0012084)1.90163628
90Redundant skin (HP:0001582)1.90026169
91Venous abnormality (HP:0002624)1.89797123
92Increased density of long bones (HP:0006392)1.88408247
93Supranuclear gaze palsy (HP:0000605)1.88093156
94Joint laxity (HP:0001388)1.87103395
95Coxa vara (HP:0002812)1.85910243
96Renal duplication (HP:0000075)1.84684947
97Scapular winging (HP:0003691)1.82964235
98Focal dystonia (HP:0004373)1.82903463
99Limb-girdle muscle weakness (HP:0003325)1.82708302
100Microglossia (HP:0000171)1.82315114
101Nonimmune hydrops fetalis (HP:0001790)1.81712841
102Syringomyelia (HP:0003396)1.80767012
103Spinal cord lesions (HP:0100561)1.80767012
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79800056
105Nemaline bodies (HP:0003798)1.79775109
106Spinal cord compression (HP:0002176)1.79165761
107Difficulty climbing stairs (HP:0003551)1.79009826
108Limited hip movement (HP:0008800)1.78900646
109Spondylolisthesis (HP:0003302)1.78853256
110Lower limb amyotrophy (HP:0007210)1.78848898
111Hip contracture (HP:0003273)1.77774878
112Osteolytic defects of the hand bones (HP:0009699)1.77244427
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.77244427
114Venous insufficiency (HP:0005293)1.76471284
115Myotonia (HP:0002486)1.75519060
116Deformed tarsal bones (HP:0008119)1.75221439
117Xanthomatosis (HP:0000991)1.75198815
118Long toe (HP:0010511)1.74844859
119Back pain (HP:0003418)1.74675663
120Osteoarthritis (HP:0002758)1.74435005
121Muscle fiber inclusion bodies (HP:0100299)1.73583035
122Narrow nasal bridge (HP:0000446)1.73299804
123Distal lower limb amyotrophy (HP:0008944)1.71791240
124Round face (HP:0000311)1.71140632
125Craniofacial dystonia (HP:0012179)1.70179133
126Hand muscle atrophy (HP:0009130)1.69226703
127Tibial bowing (HP:0002982)1.69169291
128Abnormality of the right ventricle (HP:0001707)1.69021669
129Abnormality of calcium-phosphate metabolism (HP:0100530)1.68635184
130Mitral regurgitation (HP:0001653)1.65917641
131Delayed closure of the anterior fontanelle (HP:0001476)1.65907747
132Striae distensae (HP:0001065)1.65726582
133Skin nodule (HP:0200036)1.64371455
134Delayed gross motor development (HP:0002194)1.64144963
135Chondrocalcinosis (HP:0000934)1.64144479
136Hypoalphalipoproteinemia (HP:0003233)1.62692902
137Decreased skull ossification (HP:0004331)1.62175403
138Persistence of primary teeth (HP:0006335)1.60989572
139Abnormal pancreas size (HP:0012094)1.60598341
140Vascular calcification (HP:0004934)1.60589624
141Broad long bones (HP:0005622)1.60517915
142Thin skin (HP:0000963)1.59093444
143Full cheeks (HP:0000293)1.56462006
144Abnormality of the odontoid process (HP:0003310)1.55924409
145Gingival overgrowth (HP:0000212)1.54441861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.86637404
2DDR23.55059140
3CASK3.20958944
4TRIB32.77419021
5STK162.61819226
6PDGFRA2.57044148
7TESK12.52888481
8LIMK12.52729816
9TTN2.50162529
10PAK32.34552383
11LATS12.31749261
12MAP3K92.31673060
13ERN12.06430296
14MINK12.02827589
15PTK2B1.97357836
16PAK21.92727330
17AKT31.89811781
18PIK3CG1.83359483
19NTRK31.71444082
20FER1.66904783
21PINK11.63004788
22PTK21.61769627
23ARAF1.57495755
24NTRK21.55300184
25PIK3CA1.51265154
26KSR21.50907370
27PKN21.49634450
28SIK11.46062816
29NTRK11.45722886
30PAK61.45038254
31BCR1.43133561
32PLK21.42217820
33MOS1.40537974
34ADRBK21.35943427
35FRK1.34777316
36MYLK1.32334576
37MAP3K41.29043719
38MAP2K41.28285300
39BMX1.28208262
40EPHB21.26006760
41EPHA41.25009464
42DYRK1B1.23133141
43TAOK11.20692814
44PNCK1.20587092
45DYRK21.19972808
46ERBB31.18632402
47CAMKK11.18239942
48TESK21.17532771
49MAP3K121.17167271
50MAP2K11.17045791
51PHKG21.14598854
52PHKG11.14598854
53RIPK11.13894876
54PRKD31.13408597
55DMPK1.13316486
56ICK1.13053735
57SCYL21.10187704
58MAPK131.10082214
59RET1.07710967
60MAP3K61.06123599
61KSR11.05435201
62WNK41.04004407
63MARK11.03810886
64OBSCN1.03074207
65PIM21.01575690
66FGFR11.00740573
67CDK140.97430565
68ROCK10.95030704
69TAOK30.91572816
70KIT0.90830941
71PRKD20.89746887
72CAMK10.89196541
73ERBB40.87914782
74CDK150.87491762
75WNK30.87157417
76FGFR20.85794422
77SGK2230.85331232
78SGK4940.85331232
79TGFBR20.84761143
80GRK10.84681042
81CDK180.83923129
82TRPM70.81932225
83PRKCE0.81260363
84STK380.79982392
85CDC42BPA0.79927538
86EPHA30.79824755
87DAPK30.78166701
88ABL20.74317989
89MARK20.73812617
90MAP3K130.73076416
91CDK11A0.71902793
92MAP3K30.70200947
93CAMKK20.69377612
94PRKCH0.69017405
95PDGFRB0.67843550
96MAP3K110.67059784
97RAF10.66899811
98PTK60.65863200
99PRKG10.64252334
100DYRK1A0.63615179
101SGK20.62970994
102GRK70.62317122
103MAPKAPK50.62264297
104DYRK30.62176007
105LRRK20.62096781
106NEK10.60180167
107TAOK20.59406091
108RPS6KA20.57237728
109FLT30.56513571
110MAPK40.54377281
111INSR0.54284500
112STK390.53678050
113PRKD10.53419442
114MTOR0.52517537
115MAP3K50.52516164
116MAP3K10.52321809
117DAPK20.51917204
118MAPK120.50290995
119RPS6KA40.50023300
120MAP2K70.48738437
121CDK50.48643062
122PRKACA0.48233600
123CAMK2A0.47726500
124MAPK70.47281682
125MAP3K20.47279784
126PRKCG0.47134252
127SIK20.46091602
128PRKAA10.45196149
129CAMK2G0.44358903
130ROCK20.43604238
131MET0.43040286
132SRC0.42981197
133WNK10.41371797
134FYN0.41128108
135UHMK10.40876289
136PAK10.40297312
137PRKG20.38928517
138NEK90.38762044
139STK38L0.38671834
140CAMK2D0.38358383
141CAMK40.38163561
142ADRBK10.36473382
143GRK50.34603267
144ALK0.33235280
145TYRO30.32425201
146PDK30.29491074
147PDK40.29491074

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.75839124
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27139090
3ECM-receptor interaction_Homo sapiens_hsa045122.26649819
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.02277494
5Primary bile acid biosynthesis_Homo sapiens_hsa001201.96767938
6Focal adhesion_Homo sapiens_hsa045101.83565586
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78771354
8Arginine biosynthesis_Homo sapiens_hsa002201.77915496
9Complement and coagulation cascades_Homo sapiens_hsa046101.67765738
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56957232
11Bladder cancer_Homo sapiens_hsa052191.55908421
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50866311
13Dilated cardiomyopathy_Homo sapiens_hsa054141.42963655
14Proteoglycans in cancer_Homo sapiens_hsa052051.39073273
15Synaptic vesicle cycle_Homo sapiens_hsa047211.35547611
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32337270
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27623926
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26749564
19Amoebiasis_Homo sapiens_hsa051461.24216991
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22232592
21Collecting duct acid secretion_Homo sapiens_hsa049661.22044419
22Bile secretion_Homo sapiens_hsa049761.21733641
23Cardiac muscle contraction_Homo sapiens_hsa042601.21699590
24Retinol metabolism_Homo sapiens_hsa008301.21628256
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20648662
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20109591
27Butanoate metabolism_Homo sapiens_hsa006501.20074827
28Gap junction_Homo sapiens_hsa045401.20074732
29GABAergic synapse_Homo sapiens_hsa047271.18345766
30Cocaine addiction_Homo sapiens_hsa050301.18067856
31Nicotine addiction_Homo sapiens_hsa050331.16362700
32Calcium signaling pathway_Homo sapiens_hsa040201.13996033
33Amphetamine addiction_Homo sapiens_hsa050311.11046965
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09010936
35Glioma_Homo sapiens_hsa052141.06295120
36Tryptophan metabolism_Homo sapiens_hsa003801.02341298
37Adherens junction_Homo sapiens_hsa045201.02042099
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01688484
39Protein digestion and absorption_Homo sapiens_hsa049741.00302290
40Melanoma_Homo sapiens_hsa052180.94810005
41TGF-beta signaling pathway_Homo sapiens_hsa043500.94533994
42Prion diseases_Homo sapiens_hsa050200.94475838
43Phototransduction_Homo sapiens_hsa047440.94413039
44GnRH signaling pathway_Homo sapiens_hsa049120.94395292
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94345331
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93361985
47Vibrio cholerae infection_Homo sapiens_hsa051100.92547115
48Axon guidance_Homo sapiens_hsa043600.90879121
49Circadian entrainment_Homo sapiens_hsa047130.90260660
50Taste transduction_Homo sapiens_hsa047420.89642398
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88446750
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88392992
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87846147
54Rap1 signaling pathway_Homo sapiens_hsa040150.87652848
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86910267
56Long-term potentiation_Homo sapiens_hsa047200.86874621
57Dopaminergic synapse_Homo sapiens_hsa047280.86765506
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86469950
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86319381
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86101824
61Oxytocin signaling pathway_Homo sapiens_hsa049210.84768386
62PPAR signaling pathway_Homo sapiens_hsa033200.83759276
63Ovarian steroidogenesis_Homo sapiens_hsa049130.83235696
64Gastric acid secretion_Homo sapiens_hsa049710.82804767
65Linoleic acid metabolism_Homo sapiens_hsa005910.82618811
66Thyroid hormone synthesis_Homo sapiens_hsa049180.82006979
67Hippo signaling pathway_Homo sapiens_hsa043900.81112462
68Chemical carcinogenesis_Homo sapiens_hsa052040.80464876
69Dorso-ventral axis formation_Homo sapiens_hsa043200.80316136
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78299952
71Estrogen signaling pathway_Homo sapiens_hsa049150.76999062
72Hedgehog signaling pathway_Homo sapiens_hsa043400.76871082
73Caffeine metabolism_Homo sapiens_hsa002320.75321678
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.75025382
75Glutamatergic synapse_Homo sapiens_hsa047240.74547339
76Renin secretion_Homo sapiens_hsa049240.74239284
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.73976854
78Salivary secretion_Homo sapiens_hsa049700.73534173
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73509711
80Shigellosis_Homo sapiens_hsa051310.72932995
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72772597
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71531766
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70510019
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70398929
85MicroRNAs in cancer_Homo sapiens_hsa052060.70319249
86Cholinergic synapse_Homo sapiens_hsa047250.69296107
87Long-term depression_Homo sapiens_hsa047300.69155637
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68398624
89Olfactory transduction_Homo sapiens_hsa047400.66889973
90Insulin secretion_Homo sapiens_hsa049110.65720167
91ErbB signaling pathway_Homo sapiens_hsa040120.65658252
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64687493
93MAPK signaling pathway_Homo sapiens_hsa040100.64615662
94Phagosome_Homo sapiens_hsa041450.64447327
95Morphine addiction_Homo sapiens_hsa050320.63587458
96Serotonergic synapse_Homo sapiens_hsa047260.62073382
97Malaria_Homo sapiens_hsa051440.61595017
98Melanogenesis_Homo sapiens_hsa049160.60960191
99Sulfur metabolism_Homo sapiens_hsa009200.60420784
100Mineral absorption_Homo sapiens_hsa049780.58958259
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57694734
102Pyruvate metabolism_Homo sapiens_hsa006200.57533447
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56862525
104Renin-angiotensin system_Homo sapiens_hsa046140.56832169
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55660956
106cAMP signaling pathway_Homo sapiens_hsa040240.54768065
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53128221
108Pancreatic secretion_Homo sapiens_hsa049720.52975691
109Starch and sucrose metabolism_Homo sapiens_hsa005000.52851585
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52717414
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52001878
112Glucagon signaling pathway_Homo sapiens_hsa049220.51578662
113Fatty acid degradation_Homo sapiens_hsa000710.51036161
114Phenylalanine metabolism_Homo sapiens_hsa003600.50237341
115Platelet activation_Homo sapiens_hsa046110.49216351
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.49028727
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48572789
118Tight junction_Homo sapiens_hsa045300.47599155
119Alzheimers disease_Homo sapiens_hsa050100.47357745
120Protein export_Homo sapiens_hsa030600.45956700
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45718107
122Ras signaling pathway_Homo sapiens_hsa040140.45501072
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.44782398
124Oxidative phosphorylation_Homo sapiens_hsa001900.42120869
125Regulation of autophagy_Homo sapiens_hsa041400.41708400

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