GRHL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.48581289
2desmosome organization (GO:0002934)9.26508205
3establishment of skin barrier (GO:0061436)9.16876009
4regulation of water loss via skin (GO:0033561)8.43731475
5keratinocyte differentiation (GO:0030216)5.67874093
6molting cycle (GO:0042303)5.64970908
7hair cycle (GO:0042633)5.64970908
8hemidesmosome assembly (GO:0031581)5.54328186
9multicellular organismal water homeostasis (GO:0050891)5.37906519
10lipoxygenase pathway (GO:0019372)5.26017452
11regulation of posttranscriptional gene silencing (GO:0060147)5.21690157
12regulation of gene silencing by miRNA (GO:0060964)5.21690157
13regulation of gene silencing by RNA (GO:0060966)5.21690157
14gap junction assembly (GO:0016264)5.14099091
15linoleic acid metabolic process (GO:0043651)4.79811565
16negative regulation of keratinocyte proliferation (GO:0010839)4.78695453
17epidermal cell differentiation (GO:0009913)4.60900427
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.59243514
19skin morphogenesis (GO:0043589)4.52384262
20positive regulation of epidermal cell differentiation (GO:0045606)4.48789334
21phosphatidylserine acyl-chain remodeling (GO:0036150)4.40859550
22positive regulation of epidermis development (GO:0045684)4.34752595
23peptide cross-linking (GO:0018149)4.32922652
24epithelial cell differentiation involved in prostate gland development (GO:0060742)4.32896581
25water homeostasis (GO:0030104)4.31196659
26keratinocyte proliferation (GO:0043616)4.20503196
27regulation of keratinocyte differentiation (GO:0045616)4.13941333
28ribosomal small subunit biogenesis (GO:0042274)4.08597362
29intestinal epithelial cell development (GO:0060576)4.06678472
30phosphatidylinositol acyl-chain remodeling (GO:0036149)3.98945720
31maturation of SSU-rRNA (GO:0030490)3.98725417
32viral transcription (GO:0019083)3.96962812
33intermediate filament organization (GO:0045109)3.96090495
34detection of bacterium (GO:0016045)3.91977159
35epithelial cell-cell adhesion (GO:0090136)3.90805905
36translational termination (GO:0006415)3.88816067
37intermediate filament-based process (GO:0045103)3.83762840
38paraxial mesoderm development (GO:0048339)3.83321696
39surfactant homeostasis (GO:0043129)3.77495872
40establishment of apical/basal cell polarity (GO:0035089)3.76242606
41* epidermis development (GO:0008544)3.75939228
42positive regulation of keratinocyte differentiation (GO:0045618)3.71659159
43nuclear pore organization (GO:0006999)3.67645446
44formation of translation preinitiation complex (GO:0001731)3.67590079
45regulation of keratinocyte proliferation (GO:0010837)3.67467236
46interferon-gamma secretion (GO:0072643)3.62095196
47phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.58186972
48lateral sprouting from an epithelium (GO:0060601)3.55609691
49negative regulation of interferon-gamma production (GO:0032689)3.53077476
50long-chain fatty acid biosynthetic process (GO:0042759)3.52578191
51regulation of epidermis development (GO:0045682)3.52026539
52positive regulation of SMAD protein import into nucleus (GO:0060391)3.48786368
53keratinocyte development (GO:0003334)3.47052529
54DNA replication-dependent nucleosome organization (GO:0034723)3.45950355
55DNA replication-dependent nucleosome assembly (GO:0006335)3.45950355
56phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.44580437
57nuclear pore complex assembly (GO:0051292)3.44235698
58determination of adult lifespan (GO:0008340)3.44060177
59chemical homeostasis within a tissue (GO:0048875)3.43839008
60positive regulation of Cdc42 GTPase activity (GO:0043089)3.42341196
61regulation of epidermal cell differentiation (GO:0045604)3.40176717
62* epithelium development (GO:0060429)3.39803971
63detection of other organism (GO:0098543)3.39495147
64regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.39386580
65anterior/posterior axis specification, embryo (GO:0008595)3.39279774
66mitotic sister chromatid segregation (GO:0000070)3.35325683
67ribosomal small subunit assembly (GO:0000028)3.33606895
68translational elongation (GO:0006414)3.33581330
69trophectodermal cell differentiation (GO:0001829)3.33521138
70protein localization to kinetochore (GO:0034501)3.28727433
71ribosomal large subunit biogenesis (GO:0042273)3.28181835
72translational initiation (GO:0006413)3.27865854
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26903662
74establishment or maintenance of monopolar cell polarity (GO:0061339)3.26750696
75establishment of monopolar cell polarity (GO:0061162)3.26750696
76heterochromatin organization (GO:0070828)3.24351519
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23865773
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.23865773
79ribosome assembly (GO:0042255)3.23237444
80atrioventricular valve morphogenesis (GO:0003181)3.22549590
81regulation of cardioblast differentiation (GO:0051890)3.19442862
82polarized epithelial cell differentiation (GO:0030859)3.19167317
83apical protein localization (GO:0045176)3.18031783
84regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.16282271
85ventricular cardiac muscle cell action potential (GO:0086005)3.14929357
86notochord development (GO:0030903)3.13713336
87cellular protein complex disassembly (GO:0043624)3.12985083
88mitotic nuclear envelope disassembly (GO:0007077)3.11829631
89sphingoid metabolic process (GO:0046519)3.11332263
90ribonucleoprotein complex biogenesis (GO:0022613)3.10645308
91nuclear envelope disassembly (GO:0051081)3.10305574
92membrane disassembly (GO:0030397)3.10305574
93regulation of helicase activity (GO:0051095)3.10215768
94oocyte development (GO:0048599)3.08428698
95nodal signaling pathway (GO:0038092)3.07858062
96viral life cycle (GO:0019058)3.07745877
97negative regulation of cell fate specification (GO:0009996)3.06076679
98negative regulation of epidermis development (GO:0045683)3.04768943
99hair follicle morphogenesis (GO:0031069)3.03098092
100phosphatidylcholine acyl-chain remodeling (GO:0036151)2.99472148
101DNA unwinding involved in DNA replication (GO:0006268)2.98247336
102regulation of natural killer cell differentiation (GO:0032823)2.98130906
103mitotic metaphase plate congression (GO:0007080)2.97710098
104morphogenesis of embryonic epithelium (GO:0016331)2.97324605
105* establishment of tissue polarity (GO:0007164)2.96703051
106* establishment of planar polarity (GO:0001736)2.96703051
107sister chromatid segregation (GO:0000819)2.95247927
108histone H4-K12 acetylation (GO:0043983)2.94890276
109cell-substrate junction assembly (GO:0007044)2.94793648
110citrulline biosynthetic process (GO:0019240)2.94704739
111pre-miRNA processing (GO:0031054)2.93825547
112phosphatidylserine metabolic process (GO:0006658)2.92675045
113regulation of SMAD protein import into nucleus (GO:0060390)2.88684108
114negative regulation of epidermal cell differentiation (GO:0045605)2.84979345
115regulation of hair follicle development (GO:0051797)2.83090719
116activation of Rac GTPase activity (GO:0032863)2.82816389
117epithelial cell differentiation (GO:0030855)2.82662107
118regulation of hair cycle (GO:0042634)2.81109700
119protein complex disassembly (GO:0043241)2.81032574
120asymmetric protein localization (GO:0008105)2.79755027
121SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79023605
122ribosome biogenesis (GO:0042254)2.78947481
123DNA replication initiation (GO:0006270)2.78587082
124* ectoderm development (GO:0007398)2.75541656
125regulation of histone H3-K9 methylation (GO:0051570)2.74553835
126mitotic chromosome condensation (GO:0007076)2.73787527
127regulation of mitotic spindle organization (GO:0060236)2.73169847
128protein targeting to ER (GO:0045047)2.72442058
129cotranslational protein targeting to membrane (GO:0006613)2.71969615
130muscle organ morphogenesis (GO:0048644)2.69871145
131sphingosine metabolic process (GO:0006670)2.69804957
132regulation of gene silencing (GO:0060968)2.68789556
133ceramide biosynthetic process (GO:0046513)2.68384239
134histone arginine methylation (GO:0034969)2.68339922
135cell-cell junction assembly (GO:0007043)2.67334235
136metaphase plate congression (GO:0051310)2.66271616
137molting cycle process (GO:0022404)2.64747146
138hair cycle process (GO:0022405)2.64747146
139regulation of hippo signaling (GO:0035330)2.63911971
140regulation of telomere maintenance via telomerase (GO:0032210)2.63684261
141positive regulation of chromosome segregation (GO:0051984)2.63020533
142negative regulation of androgen receptor signaling pathway (GO:0060766)2.61550611
143protein localization to chromosome, centromeric region (GO:0071459)2.60862661
144DNA duplex unwinding (GO:0032508)2.60108833
145establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60083196
146hair cell differentiation (GO:0035315)2.59965097
147macromolecular complex disassembly (GO:0032984)2.59766958
148DNA geometric change (GO:0032392)2.58682881
149cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.57922600
150diol metabolic process (GO:0034311)2.55973961
151regulation of ruffle assembly (GO:1900027)2.55924392
152nucleobase biosynthetic process (GO:0046112)2.55338813
153mitotic G1 DNA damage checkpoint (GO:0031571)2.55224760
154apoptotic process involved in morphogenesis (GO:0060561)2.54928312
155DNA replication checkpoint (GO:0000076)2.54317311
156positive regulation of hair cycle (GO:0042635)2.52811115
157positive regulation of hair follicle development (GO:0051798)2.52811115
158intermediate filament cytoskeleton organization (GO:0045104)2.52763350
159positive regulation of monocyte chemotaxis (GO:0090026)2.49834408
160response to phenylpropanoid (GO:0080184)2.49617197
161cardiac right ventricle morphogenesis (GO:0003215)2.49259752
162protein localization to microtubule (GO:0035372)2.47982141
163branching involved in mammary gland duct morphogenesis (GO:0060444)2.46811816
164alditol phosphate metabolic process (GO:0052646)2.45655322
165regulation of heart rate by cardiac conduction (GO:0086091)2.45087227
166G1 DNA damage checkpoint (GO:0044783)2.45056026
167cellular protein complex localization (GO:0034629)2.44177600
168histone H3-K36 demethylation (GO:0070544)2.43971588
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.43336161
170negative regulation of cell fate commitment (GO:0010454)2.41783773
171sequestering of metal ion (GO:0051238)2.40326038
172genitalia morphogenesis (GO:0035112)2.37984416
173regulation of cell proliferation involved in kidney development (GO:1901722)2.36999701
174endosome organization (GO:0007032)2.36789792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50657153
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.22236932
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.22236932
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.22236932
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.02645744
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.01169570
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99437577
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86362674
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.83230991
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75302725
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73292245
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.54597419
13* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45825621
14TCF3_18692474_ChIP-Seq_MEFs_Mouse2.42427249
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.33936543
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.23980852
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.15606227
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13950862
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13324842
20* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09198169
21* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.07973055
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.07477827
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06953635
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03620757
25* RUNX1_27514584_Chip-Seq_MCF-7_Human2.00248973
26TP63_17297297_ChIP-ChIP_HaCaT_Human10.0370887
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99589160
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98879737
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88766164
30ZNF263_19887448_ChIP-Seq_K562_Human1.81569160
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.78727342
32* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78025152
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73567257
34* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69014650
35KLF5_25053715_ChIP-Seq_YYC3_Human1.67748389
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67497312
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65715688
38* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.65570187
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65414391
40NANOG_18692474_ChIP-Seq_MEFs_Mouse1.64558733
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64291225
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.64263522
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62294041
44* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62168459
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61774528
46* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59602373
47* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57958624
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57409039
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56601992
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54254502
51SOX2_18692474_ChIP-Seq_MEFs_Mouse1.53459735
52* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53128642
53* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52492163
54* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.52113314
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.51020397
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47997347
57* TP63_23658742_ChIP-Seq_EP156T_Human1.47772094
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46844439
59* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.46568149
60AHR_22903824_ChIP-Seq_MCF-7_Human1.44311716
61SOX2_20726797_ChIP-Seq_SW620_Human1.42552828
62XRN2_22483619_ChIP-Seq_HELA_Human1.39740920
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39011487
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36377683
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33587397
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33315141
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32816057
68SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29116846
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27334626
70CLOCK_20551151_ChIP-Seq_293T_Human1.27059748
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.26780201
72* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24333973
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24111967
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.23812301
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23046848
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22086220
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20613513
78* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20603609
79* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20213959
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20007801
81* ATF3_27146783_Chip-Seq_COLON_Human1.16419992
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13896657
83* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13042719
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12766593
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12766593
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12708271
87AR_21909140_ChIP-Seq_LNCAP_Human1.10627060
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09761911
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.08941521
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08417009
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08001706
92EST1_17652178_ChIP-ChIP_JURKAT_Human1.07243709
93TTF2_22483619_ChIP-Seq_HELA_Human1.05420972
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.04580371
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.02992409
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.02823291
97CHD1_26751641_Chip-Seq_LNCaP_Human1.01307250
98GATA4_25053715_ChIP-Seq_YYC3_Human1.01200517
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.00852089
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.00310125
101* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99505533
102SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98807729
103SMC4_20622854_ChIP-Seq_HELA_Human0.98685623
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98288415
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.97961870
106MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97858482
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97287901
108* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97250268
109KAP1_27257070_Chip-Seq_ESCs_Mouse0.95878408
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95521854
111* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95293477
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95138311
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.94844835
114* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94343643
115* RACK7_27058665_Chip-Seq_MCF-7_Human0.93796098
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92971824
117EGR1_19374776_ChIP-ChIP_THP-1_Human0.92641298
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91846471
119* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91024374
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90263933
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.88061231
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.88052738
123* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88013766
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87350383
125ELF5_23300383_ChIP-Seq_T47D_Human0.86041911
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.85468859
127* CTCF_27219007_Chip-Seq_Bcells_Human0.85333961
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85035244
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84806772
130* TCF4_18268006_ChIP-ChIP_LS174T_Human0.83283776
131GATA6_25053715_ChIP-Seq_YYC3_Human0.81714482
132* FOXO3_23340844_ChIP-Seq_DLD1_Human0.81145005
133* KDM2B_26808549_Chip-Seq_K562_Human0.80617990
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80523800
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80469816
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80336650
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78754770
138* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78164703
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77468102
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.77322565
141GABP_17652178_ChIP-ChIP_JURKAT_Human0.77213868
142* RXR_22108803_ChIP-Seq_LS180_Human0.76210695
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.75403320
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75320348
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74916876
146* CREB1_26743006_Chip-Seq_LNCaP_Human0.73589232
147* TP63_22573176_ChIP-Seq_HFKS_Human0.73148970
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.72424852
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72229182
150LXR_22292898_ChIP-Seq_THP-1_Human0.72059980
151* GATA6_21074721_ChIP-Seq_CACO-2_Human0.69872741
152* TCF7_22412390_ChIP-Seq_EML_Mouse0.69812250
153SA1_27219007_Chip-Seq_ERYTHROID_Human0.67511632
154P68_20966046_ChIP-Seq_HELA_Human0.66863647
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.66820843
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.66820843
157BCOR_27268052_Chip-Seq_Bcells_Human0.65212125
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.64897001
159ERG_20517297_ChIP-Seq_VCAP_Human0.63598177
160* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.63445325
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63183077
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62695931
163* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58795113
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.57881566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier6.13910694
2MP0003941_abnormal_skin_development5.29099050
3MP0010234_abnormal_vibrissa_follicle4.53104233
4MP0005275_abnormal_skin_tensile4.07968483
5* MP0005501_abnormal_skin_physiology4.01528998
6MP0000579_abnormal_nail_morphology3.44568639
7MP0002254_reproductive_system_inflammat2.97251989
8* MP0001216_abnormal_epidermal_layer2.67584651
9MP0004381_abnormal_hair_follicle2.61799083
10MP0010352_gastrointestinal_tract_polyps2.58504211
11MP0000383_abnormal_hair_follicle2.56784655
12MP0003705_abnormal_hypodermis_morpholog2.56101688
13MP0010678_abnormal_skin_adnexa2.52530929
14MP0000467_abnormal_esophagus_morphology2.44269432
15MP0004957_abnormal_blastocyst_morpholog2.37761332
16MP0002060_abnormal_skin_morphology2.36529932
17MP0003878_abnormal_ear_physiology2.28546220
18MP0005377_hearing/vestibular/ear_phenot2.28546220
19MP0002098_abnormal_vibrissa_morphology2.28404433
20* MP0010771_integument_phenotype2.23883132
21* MP0003453_abnormal_keratinocyte_physiol2.15667866
22MP0008057_abnormal_DNA_replication2.12541681
23MP0000762_abnormal_tongue_morphology2.07298474
24MP0003566_abnormal_cell_adhesion2.00448519
25MP0000516_abnormal_urinary_system1.98431307
26MP0005367_renal/urinary_system_phenotyp1.98431307
27MP0000647_abnormal_sebaceous_gland1.98178693
28MP0000377_abnormal_hair_follicle1.92577416
29MP0010094_abnormal_chromosome_stability1.85833292
30MP0009379_abnormal_foot_pigmentation1.81295236
31MP0003111_abnormal_nucleus_morphology1.80746930
32MP0003693_abnormal_embryo_hatching1.79478925
33MP0005409_darkened_coat_color1.79168075
34MP0010030_abnormal_orbit_morphology1.77052615
35MP0004782_abnormal_surfactant_physiolog1.71335412
36MP0000427_abnormal_hair_cycle1.70250594
37MP0004947_skin_inflammation1.68728743
38MP0009053_abnormal_anal_canal1.60935570
39MP0000566_synostosis1.59190873
40MP0003077_abnormal_cell_cycle1.55050170
41MP0004264_abnormal_extraembryonic_tissu1.54666350
42MP0004885_abnormal_endolymph1.48708493
43MP0003136_yellow_coat_color1.42847080
44MP0004185_abnormal_adipocyte_glucose1.36944963
45MP0001849_ear_inflammation1.35741841
46MP0009931_abnormal_skin_appearance1.34453000
47MP0002653_abnormal_ependyma_morphology1.32131967
48MP0009780_abnormal_chondrocyte_physiolo1.31564893
49MP0003315_abnormal_perineum_morphology1.30983725
50MP0005451_abnormal_body_composition1.30742280
51MP0000537_abnormal_urethra_morphology1.29492567
52MP0004043_abnormal_pH_regulation1.28737599
53MP0008932_abnormal_embryonic_tissue1.26847913
54MP0005076_abnormal_cell_differentiation1.25400081
55MP0003191_abnormal_cellular_cholesterol1.24255747
56MP0000350_abnormal_cell_proliferation1.20788372
57MP0001191_abnormal_skin_condition1.20692818
58MP0005023_abnormal_wound_healing1.18185229
59MP0001243_abnormal_dermal_layer1.13301673
60MP0004133_heterotaxia1.11613657
61* MP0004197_abnormal_fetal_growth/weight/1.09642130
62* MP0002084_abnormal_developmental_patter1.06334853
63MP0002095_abnormal_skin_pigmentation1.05756594
64MP0003890_abnormal_embryonic-extraembry1.04861768
65MP0001730_embryonic_growth_arrest1.04513813
66MP0003119_abnormal_digestive_system1.04056586
67MP0000367_abnormal_coat/_hair1.03270170
68MP0003123_paternal_imprinting1.03012480
69MP0008007_abnormal_cellular_replicative1.00681772
70* MP0002085_abnormal_embryonic_tissue0.97951819
71MP0008058_abnormal_DNA_repair0.95206653
72MP0003786_premature_aging0.94512123
73MP0005380_embryogenesis_phenotype0.94068678
74MP0001672_abnormal_embryogenesis/_devel0.94068678
75MP0002086_abnormal_extraembryonic_tissu0.93421353
76MP0003755_abnormal_palate_morphology0.91951087
77MP0001346_abnormal_lacrimal_gland0.89974478
78MP0003718_maternal_effect0.87920222
79MP0001851_eye_inflammation0.85123672
80MP0005499_abnormal_olfactory_system0.85041834
81MP0005394_taste/olfaction_phenotype0.85041834
82* MP0002111_abnormal_tail_morphology0.83326207
83* MP0001697_abnormal_embryo_size0.82837947
84MP0001188_hyperpigmentation0.81315356
85MP0003950_abnormal_plasma_membrane0.79277121
86MP0003806_abnormal_nucleotide_metabolis0.78432125
87MP0008789_abnormal_olfactory_epithelium0.77972876
88MP0000627_abnormal_mammary_gland0.77458831
89MP0010307_abnormal_tumor_latency0.76700016
90MP0001293_anophthalmia0.75774320
91MP0002234_abnormal_pharynx_morphology0.75588846
92MP0003937_abnormal_limbs/digits/tail_de0.74027582
93MP0002088_abnormal_embryonic_growth/wei0.72810912
94MP0003984_embryonic_growth_retardation0.71628737
95MP0000432_abnormal_head_morphology0.71260367
96MP0005075_abnormal_melanosome_morpholog0.70178100
97MP0002080_prenatal_lethality0.69989453
98MP0002697_abnormal_eye_size0.68288746
99* MP0001340_abnormal_eyelid_morphology0.67761153
100MP0002233_abnormal_nose_morphology0.65615855
101MP0002249_abnormal_larynx_morphology0.65453018
102MP0002277_abnormal_respiratory_mucosa0.65418640
103MP0001286_abnormal_eye_development0.64484175
104MP0000678_abnormal_parathyroid_gland0.62853471
105MP0003283_abnormal_digestive_organ0.60386335
106MP0009672_abnormal_birth_weight0.57084914
107MP0002009_preneoplasia0.57020926
108MP0002092_abnormal_eye_morphology0.54125836
109* MP0001784_abnormal_fluid_regulation0.53658014
110MP0005666_abnormal_adipose_tissue0.52537190
111MP0002877_abnormal_melanocyte_morpholog0.52351959
112MP0003936_abnormal_reproductive_system0.52102393
113MP0002177_abnormal_outer_ear0.51714321
114MP0003567_abnormal_fetal_cardiomyocyte0.49798659
115MP0001348_abnormal_lacrimal_gland0.48601683
116MP0003935_abnormal_craniofacial_develop0.48600682
117MP0002089_abnormal_postnatal_growth/wei0.48342908
118MP0000462_abnormal_digestive_system0.47009473
119MP0008260_abnormal_autophagy0.36787670
120MP0003011_delayed_dark_adaptation0.35713806
121MP0005375_adipose_tissue_phenotype0.32959501
122* MP0000470_abnormal_stomach_morphology0.32820298
123MP0003638_abnormal_response/metabolism_0.30958262
124MP0000428_abnormal_craniofacial_morphol0.30038606
125MP0005248_abnormal_Harderian_gland0.27291654
126MP0005193_abnormal_anterior_eye0.25515742
127MP0004019_abnormal_vitamin_homeostasis0.25375943

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)6.53606760
2Hypotrichosis (HP:0001006)5.64301235
3Congenital ichthyosiform erythroderma (HP:0007431)5.23112174
4Plantar hyperkeratosis (HP:0007556)4.94080879
5Abnormality of the axillary hair (HP:0100134)4.87999088
6Abnormality of secondary sexual hair (HP:0009888)4.87999088
7Woolly hair (HP:0002224)4.82833008
8Palmoplantar hyperkeratosis (HP:0000972)4.63489774
9Palmar hyperkeratosis (HP:0010765)4.54514661
10Right ventricular cardiomyopathy (HP:0011663)4.48040271
11Onycholysis (HP:0001806)4.24079738
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.09435875
13Pili torti (HP:0003777)4.09354122
14Increased IgE level (HP:0003212)3.89757479
15Oral leukoplakia (HP:0002745)3.88697417
16Absent eyelashes (HP:0000561)3.86804898
17Fragile nails (HP:0001808)3.85749044
18Milia (HP:0001056)3.69017940
19Nail dystrophy (HP:0008404)3.67102119
20Erythroderma (HP:0001019)3.56403164
21Ependymoma (HP:0002888)3.38108913
22Erythema (HP:0010783)3.33317853
23Parakeratosis (HP:0001036)3.29153017
24Abnormal blistering of the skin (HP:0008066)3.21660416
25Thick nail (HP:0001805)3.15823940
26Hypohidrosis (HP:0000966)3.13722950
27Sparse eyelashes (HP:0000653)3.12333992
28Absent hair (HP:0002298)3.02924633
29Curly hair (HP:0002212)2.98977817
30Ectropion (HP:0000656)2.97019537
31Esophageal atresia (HP:0002032)2.95746381
32Corneal erosion (HP:0200020)2.92717529
33Sparse scalp hair (HP:0002209)2.90101220
34Septate vagina (HP:0001153)2.84780590
35Distal lower limb muscle weakness (HP:0009053)2.84607182
36Rib fusion (HP:0000902)2.78353334
37Selective tooth agenesis (HP:0001592)2.68450242
38Hyporeflexia of lower limbs (HP:0002600)2.65903879
39Natal tooth (HP:0000695)2.64994613
40Abnormality of placental membranes (HP:0011409)2.63909624
41Amniotic constriction ring (HP:0009775)2.63909624
42Trismus (HP:0000211)2.58670737
43Abnormality of the labia minora (HP:0012880)2.55374011
44Gangrene (HP:0100758)2.53208701
45Palmoplantar keratoderma (HP:0000982)2.50368702
46Alopecia of scalp (HP:0002293)2.48616942
47Blepharitis (HP:0000498)2.47324295
48Pustule (HP:0200039)2.46736658
49Hypoplastic labia majora (HP:0000059)2.44333642
50Concave nail (HP:0001598)2.40780199
51Ventricular tachycardia (HP:0004756)2.39703732
52Reticulocytopenia (HP:0001896)2.39626839
53Stenosis of the external auditory canal (HP:0000402)2.38757548
54Abdominal situs inversus (HP:0003363)2.38555397
55Abnormality of abdominal situs (HP:0011620)2.38555397
56Abnormal hair laboratory examination (HP:0003328)2.36079321
57Oligodontia (HP:0000677)2.35830721
58* Abnormality of the salivary glands (HP:0010286)2.34154407
59Absent radius (HP:0003974)2.33217993
60Rhabdomyosarcoma (HP:0002859)2.33183524
61Abnormality of the astrocytes (HP:0100707)2.30497170
62Astrocytoma (HP:0009592)2.30497170
63Areflexia of lower limbs (HP:0002522)2.29335081
64Premature ovarian failure (HP:0008209)2.27330341
65Dehydration (HP:0001944)2.25718185
66Anonychia (HP:0001798)2.20922168
67Autoamputation (HP:0001218)2.20201539
68Abnormality of permanent molar morphology (HP:0011071)2.20065957
69Abnormality of the dental root (HP:0006486)2.20065957
70Taurodontia (HP:0000679)2.20065957
71Conjunctival hamartoma (HP:0100780)2.19969229
72Abnormality of the labia majora (HP:0012881)2.18787074
73Absent forearm bone (HP:0003953)2.17224309
74Aplasia involving forearm bones (HP:0009822)2.17224309
75Aplasia/hypoplasia of the humerus (HP:0006507)2.17154750
76Breast hypoplasia (HP:0003187)2.16167758
77Slow-growing hair (HP:0002217)2.15132362
78Abnormality of hair growth rate (HP:0011363)2.15132362
79Colon cancer (HP:0003003)2.13178338
80Biliary tract neoplasm (HP:0100574)2.12326223
81Advanced eruption of teeth (HP:0006288)2.11865845
82Medulloblastoma (HP:0002885)2.11159750
83Brittle hair (HP:0002299)2.11073787
84Nasolacrimal duct obstruction (HP:0000579)2.04694375
85Absent thumb (HP:0009777)2.04641285
86Increased connective tissue (HP:0009025)2.04192893
87Abnormality of molar morphology (HP:0011070)2.01810699
88Abnormality of molar (HP:0011077)2.01810699
89Split foot (HP:0001839)2.01554814
90* Lip pit (HP:0100267)2.00959394
91Short humerus (HP:0005792)2.00408241
92Angiofibromas (HP:0010615)2.00108977
93Adenoma sebaceum (HP:0009720)2.00108977
94Multifactorial inheritance (HP:0001426)1.97499821
95Asplenia (HP:0001746)1.96476224
96Fused cervical vertebrae (HP:0002949)1.96472349
97Popliteal pterygium (HP:0009756)1.93964448
98Ridged nail (HP:0001807)1.93928760
99Abnormality of the dental pulp (HP:0006479)1.92812692
100Neoplasm of striated muscle (HP:0009728)1.92215553
101Pruritus (HP:0000989)1.92103854
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.92074382
103Furrowed tongue (HP:0000221)1.89459354
104Bilateral microphthalmos (HP:0007633)1.88321891
105Acanthosis nigricans (HP:0000956)1.87919667
106Labial hypoplasia (HP:0000066)1.87797894
107Missing ribs (HP:0000921)1.87090933
108Follicular hyperkeratosis (HP:0007502)1.84958739
109Atrophic scars (HP:0001075)1.84011850
110Gastrointestinal atresia (HP:0002589)1.83880532
111Abnormal hemoglobin (HP:0011902)1.82276499
112Abnormality of the lacrimal duct (HP:0011481)1.81611977
113Shawl scrotum (HP:0000049)1.80725498
114Abnormality of the preputium (HP:0100587)1.80690459
115Neoplasm of the oral cavity (HP:0100649)1.79409141
116Basal cell carcinoma (HP:0002671)1.79273391
117Glioma (HP:0009733)1.78946353
118Hypoplasia of dental enamel (HP:0006297)1.78263241
119Hyperactive renin-angiotensin system (HP:0000841)1.78086889
120Melanocytic nevus (HP:0000995)1.77646658
121Lack of skin elasticity (HP:0100679)1.77486239
122Pterygium (HP:0001059)1.77280073
123Agnosia (HP:0010524)1.77275950
124Hypoplastic female external genitalia (HP:0012815)1.76464206
125Depressed nasal tip (HP:0000437)1.76287366
126Abnormality of the labia (HP:0000058)1.73938489
127Proximal placement of thumb (HP:0009623)1.73327291
128Carious teeth (HP:0000670)1.72655788
129Laryngomalacia (HP:0001601)1.71992436
130Ankyloglossia (HP:0010296)1.71719382
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71597541
132Abnormality of the gastric mucosa (HP:0004295)1.71135338
133Chromsome breakage (HP:0040012)1.69665324
134Squamous cell carcinoma (HP:0002860)1.69509956
135Carpal bone hypoplasia (HP:0001498)1.69225426
136Supernumerary spleens (HP:0009799)1.69058051
137Xerostomia (HP:0000217)1.68367250
138Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67607647
139Recurrent corneal erosions (HP:0000495)1.66293409
140Conical tooth (HP:0000698)1.66080764
141Hamartoma of the eye (HP:0010568)1.65824087
142Duplicated collecting system (HP:0000081)1.65508763
143Fine hair (HP:0002213)1.64162720
144Aplasia cutis congenita (HP:0001057)1.58828327
145Hyperhidrosis (HP:0000975)1.58573708
146Dry skin (HP:0000958)1.58530880
147Abnormality of the fingernails (HP:0001231)1.57759424
148Anhidrosis (HP:0000970)1.57047416
149Hypoplastic toenails (HP:0001800)1.54133442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.90019189
2MAPKAPK34.20028378
3CDK123.77227060
4RPS6KB23.53466439
5BUB12.95040939
6MST42.76167509
7TTK2.67595975
8NEK12.47039624
9TRIB32.37057025
10WEE12.33066269
11LATS12.21789917
12CDC72.12544428
13LATS22.08278965
14TSSK62.01118378
15MAP3K32.00389395
16SIK11.99045283
17FER1.93583201
18MAP3K121.75937586
19SMG11.72648973
20MET1.70265398
21STK101.69032935
22STK38L1.62296319
23MST1R1.54202846
24PLK11.51153578
25CDK71.50948552
26NEK21.47710296
27GRK51.45867558
28AKT31.43294023
29SRPK11.41412585
30NEK61.40732806
31AURKA1.34786757
32PRKCI1.31461818
33MAP3K91.30171010
34TTN1.25759694
35AURKB1.23693113
36PBK1.14610427
37CHEK21.12649606
38EEF2K1.06691626
39MAP3K111.05484788
40CDK61.04467501
41PAK41.02186723
42FGFR31.00557963
43PKN21.00348732
44TYRO30.98128053
45ALK0.97782224
46EPHB20.97671543
47TESK10.94235827
48CHEK10.93815464
49DMPK0.92705206
50PIK3CA0.91017674
51MAP3K20.89902982
52MAP3K80.88443020
53ARAF0.88169241
54MAP3K130.87730066
55SCYL20.86131324
56LMTK20.84404759
57MATK0.83256837
58CDK90.83026540
59PLK30.82820231
60DDR20.81033112
61FGFR10.79184785
62FLT30.78973203
63ATR0.78634734
64IRAK30.75691152
65PDK40.75226398
66PDK30.75226398
67RPS6KB10.74214529
68BCR0.73450716
69ATM0.72792155
70BRD40.71990850
71PTK60.71608392
72CSNK1E0.71027835
73SGK4940.68336546
74SGK2230.68336546
75ICK0.68227470
76TRPM70.67184993
77CDK20.66401519
78LIMK10.64475878
79GRK10.64317702
80MELK0.64116773
81CDK40.63732455
82CAMK1G0.63292449
83TLK10.62856917
84MTOR0.62465218
85CSNK1D0.60804227
86LRRK20.59229574
87KSR20.58931318
88RIPK10.58662267
89MAP2K60.58277178
90EPHB10.55996773
91PDK20.55899505
92BRSK20.55866857
93PASK0.54910734
94DYRK30.53916752
95RPS6KA20.51899197
96GRK60.51524811
97PIM20.51517606
98ERN10.50475910
99PTK20.49953890
100MAP2K20.49636316
101FGFR40.49559419
102NME10.48927168
103MAP3K70.47997885
104MAP3K10.47802519
105MAPKAPK20.47594919
106AKT20.47557894
107FGFR20.47326697
108PAK10.46810517
109CSNK2A20.46563147
110RET0.46377752
111RPS6KA40.46137237
112CDK10.45530926
113ILK0.45307392
114STK30.45289295
115MAP3K60.44282665
116EIF2AK10.43291570
117IKBKB0.43012531
118DYRK20.42933950
119TGFBR10.42493860
120SIK30.42475168
121TAOK10.42071895
122ERBB30.41432047
123MAP2K10.39915402
124CAMK1D0.39256355
125YES10.38798049
126NME20.38669397
127PDGFRB0.38623178
128BMX0.38499569
129ZAK0.38360658
130WNK10.38126510
131CHUK0.37993441
132STK380.37708073
133PDGFRA0.37399901
134PRPF4B0.37300924
135PIM10.37278406
136RPS6KA10.35696171
137STK240.35040029
138MKNK10.33478991
139PNCK0.33218942
140KSR10.32492310
141EIF2AK30.32104775
142TAF10.31643303
143DYRK1B0.31418142
144MARK20.30458077
145MAP3K100.29335621
146SGK30.27508146
147BRAF0.25591625
148MAPKAPK50.25058387

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.11583207
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89635646
3Mismatch repair_Homo sapiens_hsa034303.61114624
4DNA replication_Homo sapiens_hsa030303.02845378
5RNA transport_Homo sapiens_hsa030132.87220607
6p53 signaling pathway_Homo sapiens_hsa041152.54108912
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.46927705
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46052746
9Spliceosome_Homo sapiens_hsa030402.44182556
10Basal cell carcinoma_Homo sapiens_hsa052172.34769374
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34755418
12Cell cycle_Homo sapiens_hsa041102.24201406
13Proteasome_Homo sapiens_hsa030502.13906249
14RNA polymerase_Homo sapiens_hsa030202.07127532
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.04897333
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.02134657
17Homologous recombination_Homo sapiens_hsa034402.00470464
18Nucleotide excision repair_Homo sapiens_hsa034202.00192468
19Linoleic acid metabolism_Homo sapiens_hsa005911.96090927
20Hedgehog signaling pathway_Homo sapiens_hsa043401.94289084
21Hippo signaling pathway_Homo sapiens_hsa043901.91056598
22Arachidonic acid metabolism_Homo sapiens_hsa005901.87365867
23Ovarian steroidogenesis_Homo sapiens_hsa049131.85793880
24Base excision repair_Homo sapiens_hsa034101.83621254
25One carbon pool by folate_Homo sapiens_hsa006701.81204764
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74043854
27Tight junction_Homo sapiens_hsa045301.66803596
28Fanconi anemia pathway_Homo sapiens_hsa034601.64906662
29GnRH signaling pathway_Homo sapiens_hsa049121.62673662
30mRNA surveillance pathway_Homo sapiens_hsa030151.56573127
31Circadian rhythm_Homo sapiens_hsa047101.53617874
32Amoebiasis_Homo sapiens_hsa051461.47516643
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47301820
34Adherens junction_Homo sapiens_hsa045201.46958489
35Bladder cancer_Homo sapiens_hsa052191.40190179
36Choline metabolism in cancer_Homo sapiens_hsa052311.39715876
37RNA degradation_Homo sapiens_hsa030181.31400617
38Sphingolipid metabolism_Homo sapiens_hsa006001.29860745
39Basal transcription factors_Homo sapiens_hsa030221.28890086
40Inositol phosphate metabolism_Homo sapiens_hsa005621.27605167
41Thyroid cancer_Homo sapiens_hsa052161.26599489
42Phenylalanine metabolism_Homo sapiens_hsa003601.25088745
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22259455
44MicroRNAs in cancer_Homo sapiens_hsa052061.20980712
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16429139
46TGF-beta signaling pathway_Homo sapiens_hsa043501.15129542
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11759492
48Oocyte meiosis_Homo sapiens_hsa041141.10746651
49Renal cell carcinoma_Homo sapiens_hsa052111.10495665
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10224071
51Pyrimidine metabolism_Homo sapiens_hsa002401.08596307
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05741151
53Chronic myeloid leukemia_Homo sapiens_hsa052201.04892123
54Glioma_Homo sapiens_hsa052141.01804309
55Insulin signaling pathway_Homo sapiens_hsa049101.01467397
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01182543
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96524259
58Long-term depression_Homo sapiens_hsa047300.94584333
59Pancreatic cancer_Homo sapiens_hsa052120.94145067
60Biosynthesis of amino acids_Homo sapiens_hsa012300.89514079
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87622970
62Epstein-Barr virus infection_Homo sapiens_hsa051690.86051031
63Non-homologous end-joining_Homo sapiens_hsa034500.85702488
64Hepatitis C_Homo sapiens_hsa051600.85694029
65Wnt signaling pathway_Homo sapiens_hsa043100.84832457
66Notch signaling pathway_Homo sapiens_hsa043300.82711656
67Folate biosynthesis_Homo sapiens_hsa007900.81853881
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80545240
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79428055
70Fructose and mannose metabolism_Homo sapiens_hsa000510.79156312
71Vibrio cholerae infection_Homo sapiens_hsa051100.78467243
72Proteoglycans in cancer_Homo sapiens_hsa052050.78252837
73Estrogen signaling pathway_Homo sapiens_hsa049150.76164938
74Endocytosis_Homo sapiens_hsa041440.75279551
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73872807
76Pathways in cancer_Homo sapiens_hsa052000.72111293
77Ether lipid metabolism_Homo sapiens_hsa005650.71979790
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71677813
79HTLV-I infection_Homo sapiens_hsa051660.71463452
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71103400
81Glutathione metabolism_Homo sapiens_hsa004800.70293701
82Viral carcinogenesis_Homo sapiens_hsa052030.69947649
83Tyrosine metabolism_Homo sapiens_hsa003500.69254390
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67759793
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65379071
86AMPK signaling pathway_Homo sapiens_hsa041520.64632913
87VEGF signaling pathway_Homo sapiens_hsa043700.64389695
88mTOR signaling pathway_Homo sapiens_hsa041500.63615496
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.63167037
90Non-small cell lung cancer_Homo sapiens_hsa052230.62791076
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.62411471
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61080847
93Small cell lung cancer_Homo sapiens_hsa052220.60355410
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.60166391
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60148016
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59640263
97ECM-receptor interaction_Homo sapiens_hsa045120.59257709
98Melanogenesis_Homo sapiens_hsa049160.55815836
99Arginine biosynthesis_Homo sapiens_hsa002200.54887344
100Steroid biosynthesis_Homo sapiens_hsa001000.54047077
101Focal adhesion_Homo sapiens_hsa045100.52145391
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.51259790
103Melanoma_Homo sapiens_hsa052180.51038692
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50986543
105Phototransduction_Homo sapiens_hsa047440.50150659
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47955135
107Shigellosis_Homo sapiens_hsa051310.47944502
108Dorso-ventral axis formation_Homo sapiens_hsa043200.47747100
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45498626
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44667771
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.43413676
112Herpes simplex infection_Homo sapiens_hsa051680.43110993
113Vitamin B6 metabolism_Homo sapiens_hsa007500.41851635
114Histidine metabolism_Homo sapiens_hsa003400.39555797
115Fatty acid elongation_Homo sapiens_hsa000620.39432611
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38887825
117Pancreatic secretion_Homo sapiens_hsa049720.38668301
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38446353
119Acute myeloid leukemia_Homo sapiens_hsa052210.36556952
120Chemical carcinogenesis_Homo sapiens_hsa052040.34481492
121Colorectal cancer_Homo sapiens_hsa052100.33524724
122Glucagon signaling pathway_Homo sapiens_hsa049220.33512461
123Galactose metabolism_Homo sapiens_hsa000520.33378330
124Systemic lupus erythematosus_Homo sapiens_hsa053220.32053798
125Antigen processing and presentation_Homo sapiens_hsa046120.30377390
126Selenocompound metabolism_Homo sapiens_hsa004500.30061061
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.28281213
128Fat digestion and absorption_Homo sapiens_hsa049750.27344317
129Carbon metabolism_Homo sapiens_hsa012000.26498528
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25914598
131HIF-1 signaling pathway_Homo sapiens_hsa040660.25320584
132Apoptosis_Homo sapiens_hsa042100.25029632
133Endometrial cancer_Homo sapiens_hsa052130.24877906
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24578356
135Axon guidance_Homo sapiens_hsa043600.23906480
136Legionellosis_Homo sapiens_hsa051340.23530633
137Pentose phosphate pathway_Homo sapiens_hsa000300.23520258
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.22896238
139Rap1 signaling pathway_Homo sapiens_hsa040150.21870510
140Purine metabolism_Homo sapiens_hsa002300.20482509
141Ras signaling pathway_Homo sapiens_hsa040140.19111815
142ErbB signaling pathway_Homo sapiens_hsa040120.18410669
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.18364141
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17676732
145Prostate cancer_Homo sapiens_hsa052150.17608101

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