GRHPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64363869
2L-phenylalanine catabolic process (GO:0006559)7.64363869
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.39360669
4L-phenylalanine metabolic process (GO:0006558)7.39360669
5aromatic amino acid family catabolic process (GO:0009074)6.63195386
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92365096
7* glyoxylate metabolic process (GO:0046487)5.89050128
8exogenous drug catabolic process (GO:0042738)5.80238081
9indole-containing compound catabolic process (GO:0042436)5.75819050
10indolalkylamine catabolic process (GO:0046218)5.75819050
11tryptophan catabolic process (GO:0006569)5.75819050
12bile acid biosynthetic process (GO:0006699)5.69706615
13kynurenine metabolic process (GO:0070189)5.66862039
14epoxygenase P450 pathway (GO:0019373)5.59292597
15cysteine metabolic process (GO:0006534)5.49355947
16tryptophan metabolic process (GO:0006568)5.41804026
17omega-hydroxylase P450 pathway (GO:0097267)5.33556995
18alpha-linolenic acid metabolic process (GO:0036109)5.32500545
19sulfur amino acid catabolic process (GO:0000098)5.26906284
20negative regulation of fibrinolysis (GO:0051918)5.25865553
21high-density lipoprotein particle remodeling (GO:0034375)5.17850048
22serine family amino acid catabolic process (GO:0009071)5.08697403
23regulation of fibrinolysis (GO:0051917)5.05415227
24urea cycle (GO:0000050)4.95553867
25urea metabolic process (GO:0019627)4.95553867
26aromatic amino acid family metabolic process (GO:0009072)4.89089366
27peptidyl-glutamic acid carboxylation (GO:0017187)4.88661435
28protein carboxylation (GO:0018214)4.88661435
29lysine catabolic process (GO:0006554)4.86464334
30lysine metabolic process (GO:0006553)4.86464334
31regulation of protein activation cascade (GO:2000257)4.84739497
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82337805
33bile acid metabolic process (GO:0008206)4.76279573
34complement activation, alternative pathway (GO:0006957)4.76132391
35regulation of triglyceride catabolic process (GO:0010896)4.69297093
36nitrogen cycle metabolic process (GO:0071941)4.65680667
37alpha-amino acid catabolic process (GO:1901606)4.64020260
38tyrosine metabolic process (GO:0006570)4.58508242
39regulation of cholesterol esterification (GO:0010872)4.58113351
40serine family amino acid biosynthetic process (GO:0009070)4.57632713
41reverse cholesterol transport (GO:0043691)4.57412230
42homocysteine metabolic process (GO:0050667)4.56812657
43glycine metabolic process (GO:0006544)4.55638116
44amino-acid betaine metabolic process (GO:0006577)4.55453999
45coenzyme catabolic process (GO:0009109)4.52411766
46regulation of complement activation (GO:0030449)4.50950347
47serine family amino acid metabolic process (GO:0009069)4.50028630
48cellular ketone body metabolic process (GO:0046950)4.49534593
49drug metabolic process (GO:0017144)4.46556923
50protein-lipid complex remodeling (GO:0034368)4.45694388
51macromolecular complex remodeling (GO:0034367)4.45694388
52plasma lipoprotein particle remodeling (GO:0034369)4.45694388
53acylglycerol homeostasis (GO:0055090)4.37859645
54triglyceride homeostasis (GO:0070328)4.37859645
55cellular amino acid catabolic process (GO:0009063)4.34850759
56negative regulation of cholesterol transport (GO:0032375)4.33776040
57negative regulation of sterol transport (GO:0032372)4.33776040
58aldehyde catabolic process (GO:0046185)4.28177456
59plasma lipoprotein particle clearance (GO:0034381)4.23536494
60glutamate metabolic process (GO:0006536)4.17602141
61regulation of plasminogen activation (GO:0010755)4.14821574
62oxidative demethylation (GO:0070989)4.13183453
63cellular modified amino acid catabolic process (GO:0042219)4.11991111
64oxaloacetate metabolic process (GO:0006107)4.11854306
65cellular biogenic amine catabolic process (GO:0042402)4.10204042
66amine catabolic process (GO:0009310)4.10204042
67indolalkylamine metabolic process (GO:0006586)4.09956205
68phospholipid efflux (GO:0033700)4.07583686
69aspartate family amino acid catabolic process (GO:0009068)4.07157916
70proline metabolic process (GO:0006560)4.06623006
71heme transport (GO:0015886)4.03563444
72ethanol oxidation (GO:0006069)4.02458109
73imidazole-containing compound metabolic process (GO:0052803)3.99042376
74benzene-containing compound metabolic process (GO:0042537)3.94653317
75short-chain fatty acid metabolic process (GO:0046459)3.92613117
76uronic acid metabolic process (GO:0006063)3.92454010
77glucuronate metabolic process (GO:0019585)3.92454010
78ethanol metabolic process (GO:0006067)3.91675634
79cofactor catabolic process (GO:0051187)3.91608855
80ketone body metabolic process (GO:1902224)3.90737836
81positive regulation of lipoprotein lipase activity (GO:0051006)3.90460640
82positive regulation of triglyceride lipase activity (GO:0061365)3.90460640
83acetyl-CoA metabolic process (GO:0006084)3.88181233
84cholesterol efflux (GO:0033344)3.87552840
85organic acid catabolic process (GO:0016054)3.86817900
86carboxylic acid catabolic process (GO:0046395)3.86817900
87phenylpropanoid metabolic process (GO:0009698)3.86290145
88bile acid and bile salt transport (GO:0015721)3.84628742
89arginine metabolic process (GO:0006525)3.80960620
90NADH metabolic process (GO:0006734)3.79839001
91cellular glucuronidation (GO:0052695)3.77744393
92L-serine metabolic process (GO:0006563)3.76640558
93dicarboxylic acid biosynthetic process (GO:0043650)3.70074655
94drug catabolic process (GO:0042737)3.67693467
95fibrinolysis (GO:0042730)3.67664085
96cholesterol homeostasis (GO:0042632)3.67005424
97fatty acid beta-oxidation (GO:0006635)3.66565680
98plasma lipoprotein particle assembly (GO:0034377)3.64653272
99blood coagulation, intrinsic pathway (GO:0007597)3.61072717
100sterol homeostasis (GO:0055092)3.61053347
101drug transmembrane transport (GO:0006855)3.60865919
102monocarboxylic acid catabolic process (GO:0072329)3.60770198
103fatty acid oxidation (GO:0019395)3.60552222
104response to nitrosative stress (GO:0051409)3.57820807
105urate metabolic process (GO:0046415)3.57669654
106fatty acid catabolic process (GO:0009062)3.55003445
107lipid oxidation (GO:0034440)3.53214882
108chaperone-mediated protein transport (GO:0072321)3.51954053
1092-oxoglutarate metabolic process (GO:0006103)3.50999097
110very long-chain fatty acid metabolic process (GO:0000038)3.50699779
111low-density lipoprotein particle remodeling (GO:0034374)3.49225459
112negative regulation of lipase activity (GO:0060192)3.45702286
113cytolysis (GO:0019835)3.45458531
114complement activation, classical pathway (GO:0006958)3.45174557
115daunorubicin metabolic process (GO:0044597)3.35263594
116polyketide metabolic process (GO:0030638)3.35263594
117doxorubicin metabolic process (GO:0044598)3.35263594
118gluconeogenesis (GO:0006094)3.34459846
119tricarboxylic acid cycle (GO:0006099)3.31039691
120monosaccharide biosynthetic process (GO:0046364)3.26890238
121proline biosynthetic process (GO:0006561)3.23445577
122negative regulation of fatty acid biosynthetic process (GO:0045717)3.22239252
123L-methionine salvage (GO:0071267)3.21747387
124L-methionine biosynthetic process (GO:0071265)3.21747387
125amino acid salvage (GO:0043102)3.21747387
126S-adenosylmethionine metabolic process (GO:0046500)3.19849431
127hexose biosynthetic process (GO:0019319)3.18985736
128regulation of lipoprotein particle clearance (GO:0010984)3.15341726
129glutamine family amino acid biosynthetic process (GO:0009084)3.13834535
130negative regulation of hemostasis (GO:1900047)3.11567172
131negative regulation of blood coagulation (GO:0030195)3.11567172
132branched-chain amino acid catabolic process (GO:0009083)3.11005882
133response to mercury ion (GO:0046689)3.10805245
134ribosomal small subunit biogenesis (GO:0042274)3.08637088
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07971366
136establishment of protein localization to mitochondrial membrane (GO:0090151)2.99905775
137* cellular aldehyde metabolic process (GO:0006081)2.99490511
138branched-chain amino acid metabolic process (GO:0009081)2.96379532
139protein activation cascade (GO:0072376)2.94462077
140aminoglycoside antibiotic metabolic process (GO:0030647)2.94439620
141primary alcohol catabolic process (GO:0034310)2.89852432
142arginine catabolic process (GO:0006527)2.88984114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.93757151
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88773031
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.45312919
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.02001295
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.47270779
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14990281
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.89256785
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10355267
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.56281739
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.29382445
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.21295412
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33435111
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33102577
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21588196
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.15203797
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13154635
17XRN2_22483619_ChIP-Seq_HELA_Human2.07638137
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07205433
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01320650
20* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6031498
21* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91962462
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89955575
23E2F7_22180533_ChIP-Seq_HELA_Human1.75794208
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67062696
25DCP1A_22483619_ChIP-Seq_HELA_Human1.63732744
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63118379
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.60989858
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60987601
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58121422
30* GABP_19822575_ChIP-Seq_HepG2_Human1.54468052
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48943705
32CLOCK_20551151_ChIP-Seq_293T_Human1.47962558
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.47432999
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.44819523
35HTT_18923047_ChIP-ChIP_STHdh_Human1.44156688
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42865355
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42495181
38VDR_21846776_ChIP-Seq_THP-1_Human1.40520010
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39396290
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.32774477
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32144207
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.30239716
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28349171
44TTF2_22483619_ChIP-Seq_HELA_Human1.27183977
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25907358
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20890969
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20068135
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.19518976
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18537026
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17664395
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17443362
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14401394
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13350619
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10955051
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10600890
56MYC_22102868_ChIP-Seq_BL_Human1.09859861
57* P68_20966046_ChIP-Seq_HELA_Human1.09754064
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09744875
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.09454259
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08923607
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08135750
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08075910
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07356213
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06575202
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06440310
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06149865
67TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05727213
68GATA1_22025678_ChIP-Seq_K562_Human1.05222777
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03923748
70FOXP3_21729870_ChIP-Seq_TREG_Human1.03278831
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02610929
72RACK7_27058665_Chip-Seq_MCF-7_Human1.01272650
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.00668164
74CIITA_25753668_ChIP-Seq_RAJI_Human1.00248686
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00094858
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99785264
77SA1_27219007_Chip-Seq_ERYTHROID_Human0.99218313
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97770257
79SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97736979
80KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96060129
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95989065
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95866018
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94921304
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93794125
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91942836
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86064856
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85185205
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85014382
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81988424
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81874136
91GATA4_25053715_ChIP-Seq_YYC3_Human0.79881996
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79696474
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.79353718
94ZNF263_19887448_ChIP-Seq_K562_Human0.79096669
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78406983
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78400248
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78115166
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77934062
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77914061
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76932178
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.74827377
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73524841
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70392755
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68999738
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.67512483
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66756654
107LXR_22292898_ChIP-Seq_THP-1_Human0.66150725
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.65221261
109CEBPB_22108803_ChIP-Seq_LS180_Human0.64644888
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63495085
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.62619891
112IRF1_19129219_ChIP-ChIP_H3396_Human0.61474016
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60822522
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.59133010
115AR_20517297_ChIP-Seq_VCAP_Human0.57857851
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.57511218
117* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56595125
118MYC_19915707_ChIP-ChIP_AK7_Human0.55160544
119* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.55041549
120* TAF2_19829295_ChIP-Seq_ESCs_Human0.54433138
121* TET1_21451524_ChIP-Seq_MESCs_Mouse0.54332752
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53900433
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.53824315
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.53307202
125P53_21459846_ChIP-Seq_SAOS-2_Human0.52050417
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51946664
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51742016
128* BCOR_27268052_Chip-Seq_Bcells_Human0.51710885
129CTCF_20526341_ChIP-Seq_ESCs_Human0.51477011
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50813992
131* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50435327
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.50067209
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.49224391
134OCT4_20526341_ChIP-Seq_ESCs_Human0.48007694
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.47912584
136NCOR_22424771_ChIP-Seq_293T_Human0.47894540
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.47723282
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.47272850
139CSB_26484114_Chip-Seq_FIBROBLAST_Human0.47087531
140* ESET_19884257_ChIP-Seq_ESCs_Mouse0.47040644
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.46306635
142EGR1_19032775_ChIP-ChIP_M12_Human0.46088481
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.45648850
144ERG_20517297_ChIP-Seq_VCAP_Human0.44746634
145* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.44673500
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43991492
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.43505479
148* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.41835392
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.41559174
150MYC_18358816_ChIP-ChIP_MESCs_Mouse0.41544242
151CBP_21632823_ChIP-Seq_H3396_Human0.41301027
152AR_21909140_ChIP-Seq_LNCAP_Human0.40451236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.89572002
2MP0005360_urolithiasis7.36035248
3MP0005085_abnormal_gallbladder_physiolo6.09921605
4MP0005365_abnormal_bile_salt5.96679676
5MP0003806_abnormal_nucleotide_metabolis4.81989916
6MP0008875_abnormal_xenobiotic_pharmacok4.79488823
7MP0003252_abnormal_bile_duct3.53328842
8MP0009840_abnormal_foam_cell3.51610394
9MP0010329_abnormal_lipoprotein_level3.36080654
10MP0003195_calcinosis3.16856318
11MP0005083_abnormal_biliary_tract3.16025988
12MP0005332_abnormal_amino_acid3.14056974
13MP0001666_abnormal_nutrient_absorption2.70954912
14MP0003191_abnormal_cellular_cholesterol2.47741682
15MP0004019_abnormal_vitamin_homeostasis2.25270870
16MP0010030_abnormal_orbit_morphology2.15271983
17MP0002118_abnormal_lipid_homeostasis2.13779403
18MP0000609_abnormal_liver_physiology2.04057314
19MP0005451_abnormal_body_composition1.91559790
20MP0001764_abnormal_homeostasis1.87257623
21MP0005319_abnormal_enzyme/_coenzyme1.84021490
22MP0002138_abnormal_hepatobiliary_system1.75926317
23MP0003868_abnormal_feces_composition1.70934888
24MP0003186_abnormal_redox_activity1.69918473
25MP0005584_abnormal_enzyme/coenzyme_acti1.69515084
26MP0000751_myopathy1.64018539
27MP0000749_muscle_degeneration1.52680987
28MP0009643_abnormal_urine_homeostasis1.51692625
29MP0008995_early_reproductive_senescence1.47040803
30MP0003011_delayed_dark_adaptation1.46476776
31MP0003656_abnormal_erythrocyte_physiolo1.44781180
32MP0006036_abnormal_mitochondrial_physio1.33734115
33MP0009697_abnormal_copulation1.31624597
34MP0005636_abnormal_mineral_homeostasis1.17980448
35MP0004145_abnormal_muscle_electrophysio1.15846857
36MP0003111_abnormal_nucleus_morphology1.14934000
37MP0000598_abnormal_liver_morphology1.13679137
38MP0010094_abnormal_chromosome_stability1.12328778
39MP0002249_abnormal_larynx_morphology1.12312844
40MP0003786_premature_aging1.09833456
41MP0004233_abnormal_muscle_weight1.09629522
42MP0003941_abnormal_skin_development1.06756399
43MP0000604_amyloidosis1.06678735
44MP0005647_abnormal_sex_gland1.04066973
45MP0005670_abnormal_white_adipose0.96771601
46MP0005376_homeostasis/metabolism_phenot0.93611239
47MP0004043_abnormal_pH_regulation0.91613030
48MP0009763_increased_sensitivity_to0.91480628
49MP0005408_hypopigmentation0.91135520
50MP0008932_abnormal_embryonic_tissue0.90238124
51MP0006035_abnormal_mitochondrial_morpho0.89865197
52MP0001661_extended_life_span0.88933072
53MP0001529_abnormal_vocalization0.88820613
54MP0002697_abnormal_eye_size0.88747982
55MP0005084_abnormal_gallbladder_morpholo0.88309125
56MP0000750_abnormal_muscle_regeneration0.86951015
57MP0009642_abnormal_blood_homeostasis0.86582405
58MP0008058_abnormal_DNA_repair0.85513310
59MP0005266_abnormal_metabolism0.84249779
60MP0005257_abnormal_intraocular_pressure0.84177397
61MP0003690_abnormal_glial_cell0.83832958
62MP0003329_amyloid_beta_deposits0.83397884
63MP0000759_abnormal_skeletal_muscle0.82980189
64MP0004087_abnormal_muscle_fiber0.82959031
65MP0008469_abnormal_protein_level0.81076333
66MP0003693_abnormal_embryo_hatching0.80423743
67MP0009764_decreased_sensitivity_to0.79983263
68MP0003705_abnormal_hypodermis_morpholog0.79315365
69MP0001756_abnormal_urination0.78558595
70MP0008789_abnormal_olfactory_epithelium0.76907155
71MP0002078_abnormal_glucose_homeostasis0.76102613
72MP0005220_abnormal_exocrine_pancreas0.75876161
73MP0000372_irregular_coat_pigmentation0.74401340
74MP0009765_abnormal_xenobiotic_induced0.73988955
75MP0010368_abnormal_lymphatic_system0.73967691
76MP0003123_paternal_imprinting0.73458603
77MP0008438_abnormal_cutaneous_collagen0.71918844
78MP0003718_maternal_effect0.71441156
79MP0000639_abnormal_adrenal_gland0.70312494
80MP0003077_abnormal_cell_cycle0.70213602
81MP0002837_dystrophic_cardiac_calcinosis0.69192923
82MP0005535_abnormal_body_temperature0.69162186
83MP0002876_abnormal_thyroid_physiology0.68450560
84MP0002254_reproductive_system_inflammat0.66463751
85MP0006292_abnormal_olfactory_placode0.65869910
86MP0000358_abnormal_cell_content/0.64262905
87MP0004272_abnormal_basement_membrane0.63982494
88MP0002971_abnormal_brown_adipose0.62883983
89MP0004130_abnormal_muscle_cell0.62741151
90MP0002282_abnormal_trachea_morphology0.61810337
91MP0004858_abnormal_nervous_system0.60955592
92MP0003315_abnormal_perineum_morphology0.60857074
93MP0005394_taste/olfaction_phenotype0.60636622
94MP0005499_abnormal_olfactory_system0.60636622
95MP0002938_white_spotting0.59158057
96MP0005334_abnormal_fat_pad0.58783891
97MP0001730_embryonic_growth_arrest0.58680214
98MP0004957_abnormal_blastocyst_morpholog0.57264694
99MP0005395_other_phenotype0.57096254
100MP0002136_abnormal_kidney_physiology0.57018466
101MP0004381_abnormal_hair_follicle0.56022138
102MP0005058_abnormal_lysosome_morphology0.55241615
103MP0001849_ear_inflammation0.54678084
104MP0009379_abnormal_foot_pigmentation0.53679368
105MP0000003_abnormal_adipose_tissue0.53468578
106MP0005666_abnormal_adipose_tissue0.52998941
107MP0003638_abnormal_response/metabolism_0.51912439
108MP0001346_abnormal_lacrimal_gland0.51798427
109MP0002089_abnormal_postnatal_growth/wei0.50736443
110MP0005448_abnormal_energy_balance0.49226334
111MP0005193_abnormal_anterior_eye0.48573912
112MP0002796_impaired_skin_barrier0.47380960
113MP0004147_increased_porphyrin_level0.47145086
114MP0000762_abnormal_tongue_morphology0.47085889
115MP0001984_abnormal_olfaction0.46752844
116MP0009053_abnormal_anal_canal0.46078205
117MP0008873_increased_physiological_sensi0.45895616
118MP0000230_abnormal_systemic_arterial0.45890273
119MP0009250_abnormal_appendicular_skeleto0.45356018
120MP0008872_abnormal_physiological_respon0.43772743
121MP0005187_abnormal_penis_morphology0.42952788
122MP0002822_catalepsy0.41921013
123MP0000920_abnormal_myelination0.40850911
124MP0003953_abnormal_hormone_level0.40668764
125MP0009672_abnormal_birth_weight0.38918480
126MP0005330_cardiomyopathy0.36789836
127MP0001765_abnormal_ion_homeostasis0.36420063
128MP0003075_altered_response_to0.36181082
129MP0009384_cardiac_valve_regurgitation0.36043133
130MP0002269_muscular_atrophy0.35500515
131MP0008874_decreased_physiological_sensi0.35161180
132MP0004883_abnormal_blood_vessel0.30887928
133MP0005166_decreased_susceptibility_to0.30323598
134MP0004142_abnormal_muscle_tone0.29436362
135MP0003959_abnormal_lean_body0.28965294
136MP0002132_abnormal_respiratory_system0.28323052
137MP0005464_abnormal_platelet_physiology0.27205504
138MP0002970_abnormal_white_adipose0.26587355
139MP0004264_abnormal_extraembryonic_tissu0.26555889
140MP0005164_abnormal_response_to0.25350912
141MP0002168_other_aberrant_phenotype0.24941591
142MP0006082_CNS_inflammation0.24839685
143MP0005165_increased_susceptibility_to0.24770718
144MP0000249_abnormal_blood_vessel0.24470971
145MP0003221_abnormal_cardiomyocyte_apopto0.24281930
146MP0000747_muscle_weakness0.23182149

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22771518
2Intrahepatic cholestasis (HP:0001406)6.68415626
3Deep venous thrombosis (HP:0002625)6.50744641
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.95391674
5Xanthomatosis (HP:0000991)5.90860254
6Prolonged partial thromboplastin time (HP:0003645)5.81776535
7Hypobetalipoproteinemia (HP:0003563)5.68312212
8Hyperlipoproteinemia (HP:0010980)5.19199008
9Hyperammonemia (HP:0001987)4.69292838
10Complement deficiency (HP:0004431)4.67504174
11Hyperglycinemia (HP:0002154)4.46817207
12Ketosis (HP:0001946)4.38211046
13Hypolipoproteinemia (HP:0010981)4.34868516
14Abnormality of glycine metabolism (HP:0010895)4.29116464
15Abnormality of serine family amino acid metabolism (HP:0010894)4.29116464
16Hyperglycinuria (HP:0003108)4.28987520
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18104755
18Abnormality of methionine metabolism (HP:0010901)4.13231399
19Joint hemorrhage (HP:0005261)4.11399236
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.10387976
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99510354
22Hypoglycemic coma (HP:0001325)3.95533556
23Abnormality of the common coagulation pathway (HP:0010990)3.92598879
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92107725
25Hypoalphalipoproteinemia (HP:0003233)3.86413663
26Fat malabsorption (HP:0002630)3.83518985
27Epidermoid cyst (HP:0200040)3.78152903
28Abnormality of fatty-acid metabolism (HP:0004359)3.72425317
29Reticulocytopenia (HP:0001896)3.68110834
30Abnormality of pyrimidine metabolism (HP:0004353)3.51709061
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42159731
32Abnormality of the intrinsic pathway (HP:0010989)3.34863571
33Abnormality of complement system (HP:0005339)3.31518296
34Ketoacidosis (HP:0001993)3.22052186
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.21128921
36Dicarboxylic aciduria (HP:0003215)3.21128921
37Cerebral edema (HP:0002181)3.18989552
38Delayed CNS myelination (HP:0002188)3.18845843
39Abnormality of serum amino acid levels (HP:0003112)3.15238544
40Conjugated hyperbilirubinemia (HP:0002908)3.12347581
41Lethargy (HP:0001254)3.11915635
42Hyperbilirubinemia (HP:0002904)3.09270498
43Gout (HP:0001997)3.07976692
44Steatorrhea (HP:0002570)3.04466863
45Hypercholesterolemia (HP:0003124)3.03447432
46Metabolic acidosis (HP:0001942)3.02072045
47Abnormality of nucleobase metabolism (HP:0010932)3.00821665
48Abnormal mitochondria in muscle tissue (HP:0008316)2.88748163
49Reduced antithrombin III activity (HP:0001976)2.84059844
50Spontaneous abortion (HP:0005268)2.78072551
51Abnormality of purine metabolism (HP:0004352)2.75377967
52Acute necrotizing encephalopathy (HP:0006965)2.71311571
53Hepatocellular carcinoma (HP:0001402)2.67476686
54Abnormality of the Achilles tendon (HP:0005109)2.62134776
55Abnormal gallbladder physiology (HP:0012438)2.57850917
56Cholecystitis (HP:0001082)2.57850917
57Vascular calcification (HP:0004934)2.57146855
58Generalized aminoaciduria (HP:0002909)2.54926349
59Abnormality of reticulocytes (HP:0004312)2.53419524
60Rhabdomyolysis (HP:0003201)2.52979362
61Vomiting (HP:0002013)2.49896575
62Irritability (HP:0000737)2.48674591
63Hypochromic microcytic anemia (HP:0004840)2.46295467
64Skin nodule (HP:0200036)2.45330643
65Abnormal gallbladder morphology (HP:0012437)2.43723544
66Increased intramyocellular lipid droplets (HP:0012240)2.42077524
67Cholelithiasis (HP:0001081)2.38107358
68Increased muscle lipid content (HP:0009058)2.36856379
69Proximal tubulopathy (HP:0000114)2.36093512
70Brushfield spots (HP:0001088)2.35975404
71Hepatocellular necrosis (HP:0001404)2.34641041
72Mitochondrial inheritance (HP:0001427)2.33592641
73Spastic diplegia (HP:0001264)2.32907443
74Abnormality of glycolysis (HP:0004366)2.32779118
75Increased serum pyruvate (HP:0003542)2.32779118
76Malnutrition (HP:0004395)2.32383769
77Systemic lupus erythematosus (HP:0002725)2.31665387
78Opisthotonus (HP:0002179)2.31263962
79Myocardial infarction (HP:0001658)2.27664986
80Hypoglycemic seizures (HP:0002173)2.27217535
81Acute encephalopathy (HP:0006846)2.26106334
82Myoglobinuria (HP:0002913)2.26015986
83Exercise-induced myalgia (HP:0003738)2.25681345
84Ragged-red muscle fibers (HP:0003200)2.25369813
85Cardiovascular calcification (HP:0011915)2.23639370
86Neonatal onset (HP:0003623)2.22786308
87Abnormality of urine glucose concentration (HP:0011016)2.22290172
88Glycosuria (HP:0003076)2.22290172
89Amyloidosis (HP:0011034)2.19197409
90Enlarged kidneys (HP:0000105)2.15613210
91Hepatic necrosis (HP:0002605)2.14274703
92Alkalosis (HP:0001948)2.13855724
93Achilles tendon contracture (HP:0001771)2.12906858
94Pancreatitis (HP:0001733)2.12723504
95Late onset (HP:0003584)2.11012293
96Acanthocytosis (HP:0001927)2.09559208
97Nephritis (HP:0000123)2.07404313
98Rickets (HP:0002748)2.07048223
99Increased CSF lactate (HP:0002490)2.07034342
100Hyperuricemia (HP:0002149)2.05192419
101Increased purine levels (HP:0004368)2.05192419
102Cerebral palsy (HP:0100021)2.04376371
103Exercise intolerance (HP:0003546)2.04328071
104Lactic acidosis (HP:0003128)2.04282188
105Abnormality of the gallbladder (HP:0005264)1.99507568
106Renal Fanconi syndrome (HP:0001994)1.99484572
107Hyperinsulinemic hypoglycemia (HP:0000825)1.99349783
108Progressive macrocephaly (HP:0004481)1.99108527
109Reticulocytosis (HP:0001923)1.99092061
110Hyperphosphaturia (HP:0003109)1.97006354
111Abnormal cartilage morphology (HP:0002763)1.94613106
112Sensorimotor neuropathy (HP:0007141)1.94237661
113Hypophosphatemic rickets (HP:0004912)1.93842295
114Nausea (HP:0002018)1.92936237
115Myopathic facies (HP:0002058)1.92926906
116Spastic paraparesis (HP:0002313)1.91349576
117Increased serum lactate (HP:0002151)1.90514599
118Abnormality of transition element cation homeostasis (HP:0011030)1.89166815
119Confusion (HP:0001289)1.89056583
120Abnormality of iron homeostasis (HP:0011031)1.87673929
121Glomerulonephritis (HP:0000099)1.86230819
122Abnormality of vitamin metabolism (HP:0100508)1.85451899
123Abnormality of DNA repair (HP:0003254)1.85377181
124Abnormal enzyme/coenzyme activity (HP:0012379)1.85032912
125Methylmalonic aciduria (HP:0012120)1.84293684
126Exercise-induced muscle cramps (HP:0003710)1.83379986
127Mitral stenosis (HP:0001718)1.81735738
128Microvesicular hepatic steatosis (HP:0001414)1.80701550
129Duplication of thumb phalanx (HP:0009942)1.80427838
130Elevated hepatic transaminases (HP:0002910)1.79515924
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76439285
132Nemaline bodies (HP:0003798)1.74892480
133Lipid accumulation in hepatocytes (HP:0006561)1.74861177
134Abnormality of cells of the erythroid lineage (HP:0012130)1.74077864
135Muscle fiber inclusion bodies (HP:0100299)1.73913866
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70157377
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70157377
138Abnormal urine phosphate concentration (HP:0012599)1.69632121
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69359540
140Progressive muscle weakness (HP:0003323)1.64031601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.77125590
2ERN14.21217288
3FGFR43.66906619
4VRK23.59534723
5SIK13.49847857
6SMG12.55276271
7ERBB42.44426613
8INSRR2.20179116
9LIMK12.15890150
10TESK12.14222113
11OXSR12.04290859
12MST1R1.85021197
13STK391.81089429
14PKN21.77747506
15PIM21.77568210
16PRPF4B1.77001635
17MAPK111.74733013
18WNK41.73103242
19FLT31.72032603
20MET1.70409122
21CCNB11.67938632
22KDR1.66940287
23STK161.63921682
24MAP2K41.62529060
25PINK11.60706473
26ZAK1.59456957
27TAOK31.52450030
28IRAK31.51246253
29NME11.48860081
30EPHB11.47108697
31ABL21.46108646
32VRK11.43308780
33PIK3CG1.42995979
34TESK21.42712814
35EEF2K1.41253969
36MAPK151.34869159
37PRKD31.30035355
38PBK1.29630253
39CDK191.28837948
40CDC71.25998982
41MAP4K11.25978301
42STK38L1.24407893
43GRK61.23672181
44ILK1.22043350
45NME21.20064885
46TRIB31.17028434
47CAMK2G1.15135746
48MUSK1.15111899
49LRRK21.14248447
50WNK31.14223253
51PKN11.14143552
52MAP3K71.13250736
53MAP3K111.06193028
54AKT21.05183032
55FGFR21.01529850
56EIF2AK10.97789336
57AURKA0.97526898
58TYK20.96949069
59TTN0.94295045
60PTK60.94175578
61TTK0.91025589
62MAPK120.89196633
63PRKAA20.87540147
64CSNK1G30.84895415
65CSNK1G10.83445443
66SCYL20.82302217
67MAP3K80.80490068
68DAPK20.80312847
69PDK30.79246150
70PDK40.79246150
71CAMK1D0.77320417
72NEK10.77182991
73PRKCZ0.76592488
74ARAF0.75783392
75NEK90.75633174
76MAPK40.75527258
77GSK3A0.75488672
78SRPK10.75176113
79AURKB0.74682798
80MAP2K20.73975564
81MAP2K30.73673990
82JAK20.72888215
83TIE10.72106557
84BRSK10.71291722
85PRKACG0.70976906
86BUB10.69498840
87ATR0.68792076
88RPS6KA50.68528897
89ICK0.67589344
90OBSCN0.67272832
91PAK10.64823495
92PAK40.64077211
93DYRK1B0.63287716
94ERBB20.62529367
95MAP3K100.62375878
96PDPK10.61892595
97MYLK0.60812636
98MAPKAPK30.60652152
99MAP2K70.59970409
100TLK10.59318254
101SGK2230.58756131
102SGK4940.58756131
103TAOK20.58610322
104CDK80.57734913
105DAPK30.56695311
106MAP3K30.56107635
107RAF10.54098410
108PDK20.53954521
109PAK20.53924970
110CDK70.53854471
111LATS10.53486624
112MOS0.51680552
113PRKCQ0.51452684
114CDK11A0.50606516
115EIF2AK30.50335777
116DAPK10.49731093
117TAF10.49481074
118NEK20.49466759
119MAPK70.49134133
120RPS6KB20.49124745
121CSNK1A1L0.48256727
122MAP2K60.48185659
123PLK10.47752614
124PHKG20.46905737
125PHKG10.46905737
126BRAF0.46361776
127MAP4K20.45874844
128CSNK1G20.45600643
129PRKAA10.44152156
130DMPK0.43939991
131CDK150.43574392
132EPHA20.43169659
133DYRK20.42634236
134CAMK2B0.41203956
135CDK140.40313205
136CSNK2A10.39285097
137PTK20.37541992
138CDK180.35762540
139PRKACB0.34597831
140PRKCG0.33988737
141CSK0.32574433
142GRK10.32022880
143PRKD10.31815890
144CDK40.30325102
145AKT30.30197019
146PRKCA0.29423073
147CSF1R0.29217257
148MTOR0.28888130
149CAMK2D0.28580673
150TGFBR20.28225122
151CSNK1E0.27832113
152PRKACA0.27804479
153TBK10.27328664
154PAK30.26932535
155PDK10.25736384
156CSNK2A20.24212911
157EPHA40.23822046
158BCR0.23738683

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06744033
2Nitrogen metabolism_Homo sapiens_hsa009103.16148975
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12138897
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97739334
5* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78210886
6Arginine biosynthesis_Homo sapiens_hsa002202.77999322
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75387633
8* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.70597162
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63187502
10Tryptophan metabolism_Homo sapiens_hsa003802.51691250
11Fatty acid degradation_Homo sapiens_hsa000712.51379227
12Complement and coagulation cascades_Homo sapiens_hsa046102.36647162
13Butanoate metabolism_Homo sapiens_hsa006502.30511988
14Propanoate metabolism_Homo sapiens_hsa006402.23249931
15Peroxisome_Homo sapiens_hsa041462.16088865
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00024417
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98623683
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98108699
19Fatty acid metabolism_Homo sapiens_hsa012121.91727624
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90033379
21Histidine metabolism_Homo sapiens_hsa003401.89048827
22Fatty acid elongation_Homo sapiens_hsa000621.83435802
23PPAR signaling pathway_Homo sapiens_hsa033201.77783491
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77350059
25Chemical carcinogenesis_Homo sapiens_hsa052041.76786734
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.71773001
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71214172
28beta-Alanine metabolism_Homo sapiens_hsa004101.71076125
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67208558
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.57867423
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56094998
32Sulfur metabolism_Homo sapiens_hsa009201.54722989
33* Pyruvate metabolism_Homo sapiens_hsa006201.52884670
34Folate biosynthesis_Homo sapiens_hsa007901.51632231
35Ribosome_Homo sapiens_hsa030101.51484015
36Phenylalanine metabolism_Homo sapiens_hsa003601.50535428
37Selenocompound metabolism_Homo sapiens_hsa004501.49095316
38Retinol metabolism_Homo sapiens_hsa008301.48619721
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.47313056
40Steroid biosynthesis_Homo sapiens_hsa001001.45240488
41Tyrosine metabolism_Homo sapiens_hsa003501.43017756
42Biosynthesis of amino acids_Homo sapiens_hsa012301.42376241
43Carbon metabolism_Homo sapiens_hsa012001.40925010
44Staphylococcus aureus infection_Homo sapiens_hsa051501.33436462
45Bile secretion_Homo sapiens_hsa049761.31072881
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.30940575
47Caffeine metabolism_Homo sapiens_hsa002321.30228904
48Fat digestion and absorption_Homo sapiens_hsa049751.26346999
49Vitamin B6 metabolism_Homo sapiens_hsa007501.25032283
50Arginine and proline metabolism_Homo sapiens_hsa003301.20979771
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15562679
52Starch and sucrose metabolism_Homo sapiens_hsa005001.13049183
53Sulfur relay system_Homo sapiens_hsa041221.06955174
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02163087
55Vitamin digestion and absorption_Homo sapiens_hsa049771.00995923
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97625940
57DNA replication_Homo sapiens_hsa030300.96107516
58ABC transporters_Homo sapiens_hsa020100.94836388
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.94614032
60Glutathione metabolism_Homo sapiens_hsa004800.93460126
61Base excision repair_Homo sapiens_hsa034100.90478076
62One carbon pool by folate_Homo sapiens_hsa006700.86568188
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86559375
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85844445
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77397543
66Pentose phosphate pathway_Homo sapiens_hsa000300.72837084
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70768037
68Glycerolipid metabolism_Homo sapiens_hsa005610.70418872
69Lysine degradation_Homo sapiens_hsa003100.67983617
70Mismatch repair_Homo sapiens_hsa034300.66430595
71* Metabolic pathways_Homo sapiens_hsa011000.63404466
72RNA polymerase_Homo sapiens_hsa030200.56778569
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52466731
74Linoleic acid metabolism_Homo sapiens_hsa005910.47259000
75Oxidative phosphorylation_Homo sapiens_hsa001900.43982270
76Fructose and mannose metabolism_Homo sapiens_hsa000510.42725375
77Fatty acid biosynthesis_Homo sapiens_hsa000610.41884798
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39098161
79Nucleotide excision repair_Homo sapiens_hsa034200.34080035
80Parkinsons disease_Homo sapiens_hsa050120.32474138
81Cardiac muscle contraction_Homo sapiens_hsa042600.32083480
82Galactose metabolism_Homo sapiens_hsa000520.31720589
83Prion diseases_Homo sapiens_hsa050200.28669854
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28540966
85Spliceosome_Homo sapiens_hsa030400.24223704
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22807897
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.22761880
88Purine metabolism_Homo sapiens_hsa002300.20203407
89N-Glycan biosynthesis_Homo sapiens_hsa005100.17242238
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.13767530
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.13258419
92Alzheimers disease_Homo sapiens_hsa050100.12126862
93Arachidonic acid metabolism_Homo sapiens_hsa005900.11373494
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08374029
95Homologous recombination_Homo sapiens_hsa034400.07163952
96Insulin resistance_Homo sapiens_hsa049310.06598708
97Alcoholism_Homo sapiens_hsa050340.06414186
98Other glycan degradation_Homo sapiens_hsa005110.05412922
99RNA transport_Homo sapiens_hsa030130.05248678
100Ether lipid metabolism_Homo sapiens_hsa005650.04272553
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02375382
102Huntingtons disease_Homo sapiens_hsa050160.01780566
103Glucagon signaling pathway_Homo sapiens_hsa049220.01178093
104Fanconi anemia pathway_Homo sapiens_hsa034600.01132819
105Protein export_Homo sapiens_hsa030600.00087821
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2042450
107Mineral absorption_Homo sapiens_hsa04978-0.1947322
108Protein digestion and absorption_Homo sapiens_hsa04974-0.1844912
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1621057
110Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1573365
111Renin-angiotensin system_Homo sapiens_hsa04614-0.1434920
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1106092
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0936755
114Pyrimidine metabolism_Homo sapiens_hsa00240-0.0598048
115Proteasome_Homo sapiens_hsa03050-0.0563254
116AMPK signaling pathway_Homo sapiens_hsa04152-0.0287013
117Regulation of autophagy_Homo sapiens_hsa04140-0.0080638

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »