GRIA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17061429
2locomotory exploration behavior (GO:0035641)5.95654179
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82327017
4vocalization behavior (GO:0071625)5.62057958
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.56956393
6synaptic vesicle maturation (GO:0016188)5.47005596
7pyrimidine nucleobase catabolic process (GO:0006208)5.40199028
8* ionotropic glutamate receptor signaling pathway (GO:0035235)5.36588248
9regulation of glutamate receptor signaling pathway (GO:1900449)5.29671840
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25926845
11synaptic vesicle exocytosis (GO:0016079)5.13114703
12protein localization to synapse (GO:0035418)4.83933373
13* glutamate receptor signaling pathway (GO:0007215)4.82386495
14exploration behavior (GO:0035640)4.82381618
15glutamate secretion (GO:0014047)4.74825976
16regulation of neuronal synaptic plasticity (GO:0048168)4.74542124
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.73461190
18* synaptic transmission, glutamatergic (GO:0035249)4.69325896
19regulation of synaptic vesicle exocytosis (GO:2000300)4.60608420
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.60423652
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.59835664
22neuronal action potential propagation (GO:0019227)4.51653200
23establishment of mitochondrion localization (GO:0051654)4.44583726
24neuron cell-cell adhesion (GO:0007158)4.38238903
25* neuron-neuron synaptic transmission (GO:0007270)4.36725942
26nucleobase catabolic process (GO:0046113)4.35481260
27neurotransmitter-gated ion channel clustering (GO:0072578)4.32428549
28positive regulation of synapse maturation (GO:0090129)4.28279498
29regulation of synapse structural plasticity (GO:0051823)4.27083636
30neurotransmitter secretion (GO:0007269)4.26962311
31regulation of synaptic vesicle transport (GO:1902803)4.26216995
32gamma-aminobutyric acid transport (GO:0015812)4.26132984
33cell migration in hindbrain (GO:0021535)4.26069232
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15643342
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15614600
36cellular potassium ion homeostasis (GO:0030007)4.07076829
37* long-term memory (GO:0007616)4.04673090
38gamma-aminobutyric acid signaling pathway (GO:0007214)4.01565406
39central nervous system projection neuron axonogenesis (GO:0021952)4.00705902
40dendritic spine morphogenesis (GO:0060997)3.93067205
41positive regulation of membrane potential (GO:0045838)3.91687309
42regulation of synaptic plasticity (GO:0048167)3.91111111
43regulation of dendritic spine morphogenesis (GO:0061001)3.89928733
44regulation of postsynaptic membrane potential (GO:0060078)3.88081028
45neuron recognition (GO:0008038)3.82485531
46response to auditory stimulus (GO:0010996)3.81406276
47synapse assembly (GO:0007416)3.80389800
48startle response (GO:0001964)3.77329845
49transmission of nerve impulse (GO:0019226)3.74715909
50sodium ion export (GO:0071436)3.74660930
51long-term synaptic potentiation (GO:0060291)3.74505823
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.73960237
53proline transport (GO:0015824)3.73282193
54layer formation in cerebral cortex (GO:0021819)3.70539815
55behavioral defense response (GO:0002209)3.70205295
56behavioral fear response (GO:0001662)3.70205295
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57414587
58positive regulation of synapse assembly (GO:0051965)3.56247222
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55208645
60axonal fasciculation (GO:0007413)3.53523108
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.52036114
62synaptic vesicle endocytosis (GO:0048488)3.50906446
63neurotransmitter transport (GO:0006836)3.50670608
64mitochondrion transport along microtubule (GO:0047497)3.49799894
65establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.49799894
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48462065
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.47042859
68fear response (GO:0042596)3.43381718
69neuromuscular process controlling balance (GO:0050885)3.42994389
70response to histamine (GO:0034776)3.39383516
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38904223
72cerebral cortex radially oriented cell migration (GO:0021799)3.38542451
73cell communication by electrical coupling (GO:0010644)3.37554590
74regulation of vesicle fusion (GO:0031338)3.37473504
75innervation (GO:0060384)3.35129684
76regulation of synapse maturation (GO:0090128)3.34737446
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.33572979
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33469047
79membrane depolarization (GO:0051899)3.33063632
80positive regulation of dendritic spine development (GO:0060999)3.32604625
81postsynaptic membrane organization (GO:0001941)3.32174306
82dendritic spine organization (GO:0097061)3.29750535
83membrane depolarization during action potential (GO:0086010)3.29299012
84cerebellar Purkinje cell differentiation (GO:0021702)3.28622838
85learning (GO:0007612)3.28340338
86regulation of neurotransmitter secretion (GO:0046928)3.27772598
87regulation of neurotransmitter levels (GO:0001505)3.27380664
88activation of protein kinase A activity (GO:0034199)3.25098647
89regulation of dendritic spine development (GO:0060998)3.24697297
90positive regulation of neurotransmitter secretion (GO:0001956)3.22711069
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22341914
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20868736
93positive regulation of vascular permeability (GO:0043117)3.20263976
94regulation of female receptivity (GO:0045924)3.17115048
95cellular sodium ion homeostasis (GO:0006883)3.16812327
96presynaptic membrane assembly (GO:0097105)3.15002281
97regulation of synaptic transmission (GO:0050804)3.14875544
98dendrite morphogenesis (GO:0048813)3.13743112
99positive regulation of neurotransmitter transport (GO:0051590)3.12290465
100central nervous system neuron axonogenesis (GO:0021955)3.11418092
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11163334
102synapse organization (GO:0050808)3.10301408
103long term synaptic depression (GO:0060292)3.09955229
104neuromuscular process controlling posture (GO:0050884)3.09334688
105vesicle transport along microtubule (GO:0047496)3.09263326
106positive regulation of synaptic transmission (GO:0050806)3.08708995
107chemosensory behavior (GO:0007635)3.07966340
108regulation of neurotransmitter transport (GO:0051588)3.07347749
109* synaptic transmission (GO:0007268)3.07198188
110neuronal ion channel clustering (GO:0045161)3.07092126
111spinal cord development (GO:0021510)3.05806694
112cerebellar granule cell differentiation (GO:0021707)3.04446582
113limb bud formation (GO:0060174)3.02202431
114presynaptic membrane organization (GO:0097090)3.02030372
115auditory behavior (GO:0031223)3.01352284
116regulation of synaptic transmission, GABAergic (GO:0032228)3.01153314
117adult walking behavior (GO:0007628)3.00718442
118glycosphingolipid biosynthetic process (GO:0006688)3.00375310
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99752244
120L-amino acid import (GO:0043092)2.98235565
121regulation of synapse assembly (GO:0051963)2.94679050
122amino acid import (GO:0043090)2.93658829
123axon extension (GO:0048675)2.90414404
124C4-dicarboxylate transport (GO:0015740)2.88596133
125calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.88239210
126negative regulation of dendrite development (GO:2000171)2.86066896
127regulation of axon extension involved in axon guidance (GO:0048841)2.84150889
128mechanosensory behavior (GO:0007638)2.83465426
129axonogenesis (GO:0007409)2.79519186
130membrane assembly (GO:0071709)2.77596840
131regulation of axon guidance (GO:1902667)2.77577422
132dendrite development (GO:0016358)2.77161496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.66810755
2* GBX2_23144817_ChIP-Seq_PC3_Human3.57397863
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20758902
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18635694
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15293871
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78732204
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78732204
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.75535583
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74157614
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70917696
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.67293671
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65637364
13DROSHA_22980978_ChIP-Seq_HELA_Human2.62559833
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62141219
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56929623
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52146920
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50979212
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.47346136
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.40451786
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.36840548
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.26301606
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.25495578
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22987292
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.20988716
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08802461
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01849224
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84330808
28AR_21572438_ChIP-Seq_LNCaP_Human1.77718097
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76342519
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75223399
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73365304
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73250169
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70654427
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.69780197
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68168095
36* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57708380
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.53977298
38TAF15_26573619_Chip-Seq_HEK293_Human1.53712145
39ZNF274_21170338_ChIP-Seq_K562_Hela1.49305090
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47081946
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45418903
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42716432
43* P300_19829295_ChIP-Seq_ESCs_Human1.39656824
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38401777
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36868213
46AR_25329375_ChIP-Seq_VCAP_Human1.32855837
47KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32503794
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31364441
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.31205862
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29612613
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29583233
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28914348
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.27924815
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27801609
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27355633
56STAT3_23295773_ChIP-Seq_U87_Human1.23740666
57* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22865456
58* AR_19668381_ChIP-Seq_PC3_Human1.21753053
59* CBX2_27304074_Chip-Seq_ESCs_Mouse1.19956055
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19089483
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.18539139
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15818749
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15752671
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15642275
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.15402974
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14964520
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14394060
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14314451
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14101205
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.12392939
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.12323356
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12008012
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11107056
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10542160
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09110567
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08784095
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.08531170
78* TCF4_23295773_ChIP-Seq_U87_Human1.08518639
79IGF1R_20145208_ChIP-Seq_DFB_Human1.07379897
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06884091
81CBP_20019798_ChIP-Seq_JUKART_Human1.06884091
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06149159
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.05623951
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04888452
85KDM2B_26808549_Chip-Seq_REH_Human1.04114730
86* SOX9_26525672_Chip-Seq_HEART_Mouse1.03889823
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03667322
88EWS_26573619_Chip-Seq_HEK293_Human1.03337650
89TP53_16413492_ChIP-PET_HCT116_Human1.03196654
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03110934
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02021910
92* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01466592
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00192233
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99820542
95* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99566981
96FUS_26573619_Chip-Seq_HEK293_Human0.98882237
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98455448
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.97982952
99RUNX2_22187159_ChIP-Seq_PCA_Human0.97830035
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97775396
101AHR_22903824_ChIP-Seq_MCF-7_Human0.97581275
102RNF2_27304074_Chip-Seq_NSC_Mouse0.97209556
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96958387
104* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96909017
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96738938
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96578936
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96137935
108* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95405842
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94597792
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94295214
111KDM2B_26808549_Chip-Seq_K562_Human0.94054740
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94024673
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93375541
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.91611735
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91581977
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91580815
117JUN_21703547_ChIP-Seq_K562_Human0.90487198
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90383126
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88905325
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88310049
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88310049
122* TP53_18474530_ChIP-ChIP_U2OS_Human0.86783279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.14287692
2MP0003880_abnormal_central_pattern5.32746705
3* MP0003635_abnormal_synaptic_transmissio4.45774939
4* MP0009745_abnormal_behavioral_response3.69329981
5* MP0002063_abnormal_learning/memory/cond3.60150510
6MP0004270_analgesia3.59561229
7MP0002064_seizures3.36720576
8MP0009046_muscle_twitch3.10098076
9MP0002822_catalepsy2.98438844
10* MP0002572_abnormal_emotion/affect_behav2.95724037
11* MP0002272_abnormal_nervous_system2.71969425
12* MP0001968_abnormal_touch/_nociception2.64766852
13MP0001501_abnormal_sleep_pattern2.57741679
14MP0005423_abnormal_somatic_nervous2.54244489
15MP0001486_abnormal_startle_reflex2.54066161
16MP0002734_abnormal_mechanical_nocicepti2.49608561
17MP0001440_abnormal_grooming_behavior2.32309812
18MP0008569_lethality_at_weaning1.96489205
19* MP0002735_abnormal_chemical_nociception1.96000370
20* MP0002067_abnormal_sensory_capabilities1.94191656
21MP0002733_abnormal_thermal_nociception1.91283857
22MP0003329_amyloid_beta_deposits1.89823498
23MP0009780_abnormal_chondrocyte_physiolo1.87714043
24MP0002184_abnormal_innervation1.82637764
25* MP0002736_abnormal_nociception_after1.81753491
26MP0003787_abnormal_imprinting1.80571833
27* MP0001970_abnormal_pain_threshold1.80137866
28MP0000778_abnormal_nervous_system1.78833368
29MP0004858_abnormal_nervous_system1.74925809
30MP0004811_abnormal_neuron_physiology1.74309606
31* MP0002557_abnormal_social/conspecific_i1.67094260
32MP0005646_abnormal_pituitary_gland1.66430095
33MP0005386_behavior/neurological_phenoty1.64533819
34MP0004924_abnormal_behavior1.64533819
35MP0002909_abnormal_adrenal_gland1.61650950
36MP0004885_abnormal_endolymph1.57766568
37MP0003879_abnormal_hair_cell1.51713882
38MP0006276_abnormal_autonomic_nervous1.48272352
39* MP0000955_abnormal_spinal_cord1.44128305
40MP0003121_genomic_imprinting1.43460924
41* MP0002066_abnormal_motor_capabilities/c1.42742658
42* MP0002882_abnormal_neuron_morphology1.38307635
43MP0003633_abnormal_nervous_system1.37288804
44MP0001984_abnormal_olfaction1.34404161
45MP0001529_abnormal_vocalization1.30458942
46MP0005645_abnormal_hypothalamus_physiol1.26469911
47MP0001188_hyperpigmentation1.24634804
48MP0001502_abnormal_circadian_rhythm1.22789872
49MP0001905_abnormal_dopamine_level1.22763809
50MP0004142_abnormal_muscle_tone1.21832019
51MP0003631_nervous_system_phenotype1.17367614
52MP0002152_abnormal_brain_morphology1.10969798
53MP0003122_maternal_imprinting1.09063037
54MP0004145_abnormal_muscle_electrophysio1.04723334
55MP0002653_abnormal_ependyma_morphology1.03395122
56MP0003075_altered_response_to1.03009818
57MP0001177_atelectasis0.99022204
58MP0005187_abnormal_penis_morphology0.98921917
59MP0000751_myopathy0.98828837
60MP0008872_abnormal_physiological_respon0.98039469
61MP0002069_abnormal_eating/drinking_beha0.96987334
62MP0008874_decreased_physiological_sensi0.96918997
63MP0005367_renal/urinary_system_phenotyp0.93742133
64MP0000516_abnormal_urinary_system0.93742133
65MP0000026_abnormal_inner_ear0.93266260
66MP0002229_neurodegeneration0.91748077
67MP0001986_abnormal_taste_sensitivity0.91713325
68MP0002837_dystrophic_cardiac_calcinosis0.91008423
69MP0001299_abnormal_eye_distance/0.90610312
70MP0002751_abnormal_autonomic_nervous0.90234463
71MP0003136_yellow_coat_color0.89797221
72MP0004510_myositis0.89273917
73MP0000049_abnormal_middle_ear0.89116909
74MP0002102_abnormal_ear_morphology0.88706765
75MP0003690_abnormal_glial_cell0.88211141
76MP0003632_abnormal_nervous_system0.86978554
77MP0004215_abnormal_myocardial_fiber0.86896026
78MP0004085_abnormal_heartbeat0.86417910
79MP0010386_abnormal_urinary_bladder0.86331343
80MP0003938_abnormal_ear_development0.86114859
81MP0000604_amyloidosis0.85156918
82MP0005551_abnormal_eye_electrophysiolog0.82763674
83MP0004484_altered_response_of0.82428336
84MP0001963_abnormal_hearing_physiology0.81605508
85MP0002876_abnormal_thyroid_physiology0.81473845
86MP0005535_abnormal_body_temperature0.80749659
87MP0005409_darkened_coat_color0.79536200
88MP0003385_abnormal_body_wall0.79204394
89MP0003634_abnormal_glial_cell0.77279017
90MP0005253_abnormal_eye_physiology0.76958078
91MP0004742_abnormal_vestibular_system0.75626113
92MP0005167_abnormal_blood-brain_barrier0.75246611
93MP0003119_abnormal_digestive_system0.74295148
94MP0000920_abnormal_myelination0.74031456
95MP0008877_abnormal_DNA_methylation0.73132185
96MP0000534_abnormal_ureter_morphology0.73065628
97MP0000013_abnormal_adipose_tissue0.72684974
98MP0005623_abnormal_meninges_morphology0.72044942
99MP0010770_preweaning_lethality0.71847067
100MP0002082_postnatal_lethality0.71847067
101MP0004133_heterotaxia0.71017529
102MP0002081_perinatal_lethality0.70983982
103MP0005499_abnormal_olfactory_system0.70642793
104MP0005394_taste/olfaction_phenotype0.70642793
105MP0002752_abnormal_somatic_nervous0.69136157
106MP0010768_mortality/aging0.67710292
107MP0003283_abnormal_digestive_organ0.67558200
108MP0003137_abnormal_impulse_conducting0.67085817
109MP0005248_abnormal_Harderian_gland0.65976415
110MP0001485_abnormal_pinna_reflex0.65425090
111MP0008961_abnormal_basal_metabolism0.63781067
112MP0002233_abnormal_nose_morphology0.62924918
113MP0004233_abnormal_muscle_weight0.62535635
114MP0006292_abnormal_olfactory_placode0.62524295
115MP0003755_abnormal_palate_morphology0.62200359
116MP0001664_abnormal_digestion0.62065995
117MP0000631_abnormal_neuroendocrine_gland0.62013439
118MP0002090_abnormal_vision0.61702732
119MP0002638_abnormal_pupillary_reflex0.59595033
120MP0000569_abnormal_digit_pigmentation0.59274896
121MP0004043_abnormal_pH_regulation0.55480731
122MP0010234_abnormal_vibrissa_follicle0.54825829
123MP0002234_abnormal_pharynx_morphology0.54010760
124MP0003861_abnormal_nervous_system0.53203820
125MP0010769_abnormal_survival0.52654680
126MP0001943_abnormal_respiration0.50600793
127MP0001765_abnormal_ion_homeostasis0.50111717

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.80099430
2Myokymia (HP:0002411)7.40962649
3Focal seizures (HP:0007359)6.10917739
4Visual hallucinations (HP:0002367)5.52000166
5Atonic seizures (HP:0010819)4.94850513
6Epileptic encephalopathy (HP:0200134)4.93715607
7Progressive cerebellar ataxia (HP:0002073)4.89259971
8Febrile seizures (HP:0002373)4.88577942
9Absence seizures (HP:0002121)4.48611989
10Action tremor (HP:0002345)4.22425786
11Dialeptic seizures (HP:0011146)4.17681842
12Generalized tonic-clonic seizures (HP:0002069)4.12678060
13Broad-based gait (HP:0002136)3.72994431
14Gaze-evoked nystagmus (HP:0000640)3.68293470
15Hyperventilation (HP:0002883)3.57380396
16Dysdiadochokinesis (HP:0002075)3.52780207
17Impaired vibration sensation in the lower limbs (HP:0002166)3.50266665
18Supranuclear gaze palsy (HP:0000605)3.46526737
19Dysmetria (HP:0001310)3.46383594
20Limb dystonia (HP:0002451)3.41307860
21Abnormality of the lower motor neuron (HP:0002366)3.33124318
22Depression (HP:0000716)3.31366355
23Poor eye contact (HP:0000817)3.31137194
24Truncal ataxia (HP:0002078)3.15862987
25Anxiety (HP:0000739)3.14971965
26Amblyopia (HP:0000646)3.14433563
27Morphological abnormality of the middle ear (HP:0008609)3.11196277
28Abnormality of binocular vision (HP:0011514)3.05870507
29Diplopia (HP:0000651)3.05870507
30Impaired social interactions (HP:0000735)3.02594805
31Abnormal social behavior (HP:0012433)3.02594805
32Genetic anticipation (HP:0003743)3.01993232
33Impaired smooth pursuit (HP:0007772)2.99738009
34Abnormal eating behavior (HP:0100738)2.99065407
35Hemiparesis (HP:0001269)2.98109486
36Postural instability (HP:0002172)2.95217781
37Neonatal short-limb short stature (HP:0008921)2.93135492
38Scanning speech (HP:0002168)2.91556410
39Excessive salivation (HP:0003781)2.90058894
40Drooling (HP:0002307)2.90058894
41Ankle clonus (HP:0011448)2.84731918
42Urinary bladder sphincter dysfunction (HP:0002839)2.83853130
43Mutism (HP:0002300)2.81238128
44Cerebral inclusion bodies (HP:0100314)2.81006179
45Hemiplegia (HP:0002301)2.77744902
46Neurofibrillary tangles (HP:0002185)2.68587450
47Intention tremor (HP:0002080)2.64247239
48Abnormality of ocular smooth pursuit (HP:0000617)2.63703463
49Epileptiform EEG discharges (HP:0011182)2.58752502
50Progressive inability to walk (HP:0002505)2.57863777
51Bradykinesia (HP:0002067)2.52809312
52Stereotypic behavior (HP:0000733)2.51593211
53Dysmetric saccades (HP:0000641)2.48825174
54Focal dystonia (HP:0004373)2.44938925
55Torticollis (HP:0000473)2.44313226
56Spastic gait (HP:0002064)2.43981906
57Urinary urgency (HP:0000012)2.41959161
58Absent speech (HP:0001344)2.36672305
59Status epilepticus (HP:0002133)2.36667963
60Gait imbalance (HP:0002141)2.36656340
61Mild short stature (HP:0003502)2.34675493
62Annular pancreas (HP:0001734)2.34170101
63EEG with generalized epileptiform discharges (HP:0011198)2.33604472
64Impaired vibratory sensation (HP:0002495)2.33160251
65Ventricular fibrillation (HP:0001663)2.31367999
66Papilledema (HP:0001085)2.31040301
67Lissencephaly (HP:0001339)2.25549252
68Exotropia (HP:0000577)2.23671427
69Fetal akinesia sequence (HP:0001989)2.22268998
70Megalencephaly (HP:0001355)2.20412589
71Pachygyria (HP:0001302)2.19330925
72Hypsarrhythmia (HP:0002521)2.19307448
73Cortical dysplasia (HP:0002539)2.19243628
74Hypoplasia of the corpus callosum (HP:0002079)2.16971647
75Abnormality of the labia minora (HP:0012880)2.16617258
76Abnormality of the ischium (HP:0003174)2.12631364
77Generalized myoclonic seizures (HP:0002123)2.12073943
78Split foot (HP:0001839)2.08522006
79Amyotrophic lateral sclerosis (HP:0007354)2.08064031
80Incomplete penetrance (HP:0003829)2.07658928
81Spastic tetraplegia (HP:0002510)2.07239563
82Pointed chin (HP:0000307)2.06429073
83Abnormality of the corticospinal tract (HP:0002492)2.05736296
84Inability to walk (HP:0002540)2.04624778
85Craniofacial dystonia (HP:0012179)2.04555075
86Hammertoe (HP:0001765)2.01732900
87Gait ataxia (HP:0002066)2.01547708
88Termporal pattern (HP:0011008)2.01545706
89Insidious onset (HP:0003587)2.01545706
90Cutaneous finger syndactyly (HP:0010554)2.01012524
91Polyphagia (HP:0002591)2.00552589
92Peripheral hypomyelination (HP:0007182)1.99501510
93Lower limb muscle weakness (HP:0007340)1.98222659
94Neuronal loss in central nervous system (HP:0002529)1.97763273
95Psychosis (HP:0000709)1.96305159
96Specific learning disability (HP:0001328)1.95812057
97Esotropia (HP:0000565)1.95148750
98Delusions (HP:0000746)1.94407287
99Abnormality of salivation (HP:0100755)1.94311433
100Lower limb asymmetry (HP:0100559)1.94171131
101Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92998735
102Hypoplasia of the brainstem (HP:0002365)1.92998735
103Morphological abnormality of the pyramidal tract (HP:0002062)1.91995819
104Hepatoblastoma (HP:0002884)1.91965395
105Ulnar claw (HP:0001178)1.90458148
106Abnormality of saccadic eye movements (HP:0000570)1.86557183
107Blue irides (HP:0000635)1.86002651
108Protruding tongue (HP:0010808)1.85653175
109Increased circulating renin level (HP:0000848)1.84770864
110Agitation (HP:0000713)1.84165052
111Obstructive sleep apnea (HP:0002870)1.84142429
112Abnormal EKG (HP:0003115)1.81411343
113Rapidly progressive (HP:0003678)1.80544658
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.79055418
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79055418
116Oligodactyly (hands) (HP:0001180)1.78367137
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78081203
118Thickened helices (HP:0000391)1.76270780
119Vitreoretinal degeneration (HP:0000655)1.75784611
120Insomnia (HP:0100785)1.75276395
121Bundle branch block (HP:0011710)1.74730035
122Rigidity (HP:0002063)1.74671380
123Inappropriate behavior (HP:0000719)1.72849295
124Pheochromocytoma (HP:0002666)1.72672999
125Anosmia (HP:0000458)1.71646386
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71470755
127Neuroendocrine neoplasm (HP:0100634)1.70393962
128Optic nerve hypoplasia (HP:0000609)1.70167957
129Sleep apnea (HP:0010535)1.70123456
130Decreased circulating renin level (HP:0003351)1.69163643
131Congenital primary aphakia (HP:0007707)1.68849763
132Horizontal nystagmus (HP:0000666)1.68703417
133Genital tract atresia (HP:0001827)1.68382837
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.68366512
135Failure to thrive in infancy (HP:0001531)1.67409202
136Cupped ear (HP:0000378)1.67371521
137Cutaneous syndactyly (HP:0012725)1.67261206
138Medial flaring of the eyebrow (HP:0010747)1.66217702
139Retinal dysplasia (HP:0007973)1.65004703
140Renal hypoplasia (HP:0000089)1.64065496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.54575101
2NTRK35.41651896
3MAP3K93.45674560
4MAP3K42.94024051
5MINK12.60310741
6MAP2K72.53013488
7MARK12.52199749
8RIPK42.40065267
9BCR2.20628564
10KSR22.16763013
11DAPK22.11688421
12NTRK21.98973861
13PAK61.97445436
14PRKD31.90283613
15TNIK1.88593061
16MAP2K41.86107481
17MAP3K121.85087033
18CAMKK11.77419711
19KSR11.76046907
20PRPF4B1.71951004
21FES1.68331042
22DAPK11.61730921
23ARAF1.60970136
24CASK1.58068571
25NTRK11.57081679
26CDK51.52046353
27PLK21.51616531
28MAP3K131.51513136
29STK381.44809904
30DYRK21.43561811
31GRK51.32417137
32SIK21.29121730
33PNCK1.23589104
34TRIM281.21415457
35EPHB21.19929999
36MAPK131.18947989
37PTK2B1.16521872
38* PRKCG1.11863630
39MAP3K21.09642203
40CDK191.05358247
41* CAMK2A1.04799283
42BMPR21.03391472
43RAF11.02559972
44CAMK11.01634642
45CAMKK20.97206481
46TYRO30.96910417
47NME10.95916104
48SGK4940.88691606
49SGK2230.88691606
50SGK20.84549957
51PINK10.82605420
52CDK180.82514219
53* CAMK2B0.82463265
54UHMK10.81237198
55CDK150.81063556
56FRK0.80978747
57MAP4K20.79259405
58SGK10.78786377
59CDK140.76884238
60PRKCH0.76810821
61PKN10.76369037
62PHKG10.74973054
63PHKG20.74973054
64FER0.74834096
65DYRK1A0.73660994
66STK110.73451146
67MARK20.70084888
68RIPK10.69771653
69CDK11A0.69651241
70SGK30.69269223
71PDK10.68560027
72EPHA30.66870714
73ERBB30.64848573
74TAOK10.64180901
75CSNK1G30.63968648
76STK38L0.63916448
77RPS6KA40.63905617
78PAK30.62906501
79RET0.62309869
80MAP3K70.62194220
81TNK20.62073659
82CSNK1A1L0.61536794
83FGR0.60773669
84PDPK10.60017213
85LMTK20.59406698
86LATS20.58143942
87OXSR10.57657218
88ALK0.56871721
89PRKCE0.56313328
90MAP3K10.55780884
91CSNK1G10.53198288
92YES10.52509385
93NEK60.50819572
94STK390.49400645
95CSNK1G20.49335598
96RPS6KA30.49158424
97AKT30.48710762
98BRD40.47589113
99CSNK1D0.47492080
100PRKCZ0.47481072
101CAMK40.46791610
102FYN0.46256292
103BRAF0.45696780
104MAPK100.45358472
105ROCK10.44007691
106MKNK20.43902518
107CDC42BPA0.42910187
108MAP3K60.42810785
109DMPK0.40979030
110PKN20.39819352
111MAP2K10.39742715
112ROCK20.37061214
113CCNB10.35963416
114WNK10.34417818
115CSNK1E0.33551850
116PRKCB0.33476558
117* CAMK2D0.33218315
118ERBB20.32649606
119CDK30.32403142
120CSNK1A10.31653513
121PRKACB0.31550272
122* PRKCA0.31000416
123CAMK1G0.30934665
124MAPK80.30929712
125GSK3B0.30157165
126DYRK1B0.29113329
127MOS0.29055617
128MAPK90.28893719
129WNK30.28569524
130FGFR20.27978069
131* PRKACA0.27379556
132PRKG10.26119074
133TAOK20.26100503

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050334.08303590
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05402455
3* Long-term potentiation_Homo sapiens_hsa047202.92447266
4* Circadian entrainment_Homo sapiens_hsa047132.83791500
5GABAergic synapse_Homo sapiens_hsa047272.82373182
6* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80264440
7* Glutamatergic synapse_Homo sapiens_hsa047242.76556305
8Olfactory transduction_Homo sapiens_hsa047402.71475640
9Morphine addiction_Homo sapiens_hsa050322.62313625
10* Amphetamine addiction_Homo sapiens_hsa050312.52833877
11Salivary secretion_Homo sapiens_hsa049702.32576946
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21645492
13* Dopaminergic synapse_Homo sapiens_hsa047282.12027395
14Insulin secretion_Homo sapiens_hsa049111.97614364
15Gastric acid secretion_Homo sapiens_hsa049711.95976082
16Taste transduction_Homo sapiens_hsa047421.94776752
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93856913
18Cholinergic synapse_Homo sapiens_hsa047251.89189142
19Calcium signaling pathway_Homo sapiens_hsa040201.80689244
20* Long-term depression_Homo sapiens_hsa047301.74303775
21Oxytocin signaling pathway_Homo sapiens_hsa049211.72310906
22Renin secretion_Homo sapiens_hsa049241.71889319
23Serotonergic synapse_Homo sapiens_hsa047261.67844830
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62372618
25Cocaine addiction_Homo sapiens_hsa050301.57688706
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51604421
27GnRH signaling pathway_Homo sapiens_hsa049121.49705290
28Collecting duct acid secretion_Homo sapiens_hsa049661.43648599
29* cAMP signaling pathway_Homo sapiens_hsa040241.33253197
30Gap junction_Homo sapiens_hsa045401.30119193
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29156788
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24805782
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24434623
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23788011
35Type II diabetes mellitus_Homo sapiens_hsa049301.19095075
36Estrogen signaling pathway_Homo sapiens_hsa049151.14696661
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14153934
38Glioma_Homo sapiens_hsa052141.12070936
39* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09338342
40Axon guidance_Homo sapiens_hsa043601.08471676
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08262727
42Melanogenesis_Homo sapiens_hsa049161.02821985
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98317522
44ErbB signaling pathway_Homo sapiens_hsa040120.98226044
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.95467670
46Pancreatic secretion_Homo sapiens_hsa049720.95433782
47Cardiac muscle contraction_Homo sapiens_hsa042600.94030161
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86030691
49Vibrio cholerae infection_Homo sapiens_hsa051100.85586489
50Oocyte meiosis_Homo sapiens_hsa041140.85501209
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.84889570
52Thyroid hormone synthesis_Homo sapiens_hsa049180.83777628
53Nitrogen metabolism_Homo sapiens_hsa009100.82870582
54Choline metabolism in cancer_Homo sapiens_hsa052310.82173324
55Hedgehog signaling pathway_Homo sapiens_hsa043400.81704874
56Butanoate metabolism_Homo sapiens_hsa006500.76292090
57* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74336303
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73513364
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73240585
60Hippo signaling pathway_Homo sapiens_hsa043900.72373048
61Dilated cardiomyopathy_Homo sapiens_hsa054140.71884106
62Phototransduction_Homo sapiens_hsa047440.68325853
63MAPK signaling pathway_Homo sapiens_hsa040100.67365157
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65413345
65VEGF signaling pathway_Homo sapiens_hsa043700.65218099
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63278738
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61890956
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60394670
69Glucagon signaling pathway_Homo sapiens_hsa049220.59324317
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58820951
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58771474
72Renal cell carcinoma_Homo sapiens_hsa052110.56907837
73Rap1 signaling pathway_Homo sapiens_hsa040150.56084389
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.55923434
75Ras signaling pathway_Homo sapiens_hsa040140.55810173
76Tight junction_Homo sapiens_hsa045300.55132843
77Bile secretion_Homo sapiens_hsa049760.53531774
78Protein digestion and absorption_Homo sapiens_hsa049740.52945102
79Type I diabetes mellitus_Homo sapiens_hsa049400.50752957
80African trypanosomiasis_Homo sapiens_hsa051430.50397123
81Inositol phosphate metabolism_Homo sapiens_hsa005620.49798031
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48620025
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.46385984
84mTOR signaling pathway_Homo sapiens_hsa041500.44510435
85Ether lipid metabolism_Homo sapiens_hsa005650.43621358
86AMPK signaling pathway_Homo sapiens_hsa041520.42878526
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42734669
88Alcoholism_Homo sapiens_hsa050340.42532517
89Circadian rhythm_Homo sapiens_hsa047100.40029830
90Non-small cell lung cancer_Homo sapiens_hsa052230.39863769
91Wnt signaling pathway_Homo sapiens_hsa043100.39637736
92Alzheimers disease_Homo sapiens_hsa050100.39634422
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39432508
94Prion diseases_Homo sapiens_hsa050200.38021134
95Basal cell carcinoma_Homo sapiens_hsa052170.37791007
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37787433
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37769091
98Endocytosis_Homo sapiens_hsa041440.37414143
99Colorectal cancer_Homo sapiens_hsa052100.35357179
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33749881
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33080540
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31748408
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31696687
104Melanoma_Homo sapiens_hsa052180.30781430
105Ovarian steroidogenesis_Homo sapiens_hsa049130.30734646
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30317776
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29630879
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29233902
109Endometrial cancer_Homo sapiens_hsa052130.28921419
110Chemokine signaling pathway_Homo sapiens_hsa040620.28394600
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28143932
112Insulin signaling pathway_Homo sapiens_hsa049100.27612116
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27487892
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27287457
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26885717
116Mineral absorption_Homo sapiens_hsa049780.25499297

Most similar genes based on co-expression Upload to Enrichr

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