GRID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99134662
2locomotory exploration behavior (GO:0035641)5.98618629
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82561168
4vocalization behavior (GO:0071625)5.78788572
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.72718742
6central nervous system myelination (GO:0022010)5.32430008
7axon ensheathment in central nervous system (GO:0032291)5.32430008
8regulation of glutamate receptor signaling pathway (GO:1900449)5.26976845
9neuron cell-cell adhesion (GO:0007158)5.14772030
10synaptic vesicle maturation (GO:0016188)5.14205298
11synaptic vesicle exocytosis (GO:0016079)5.06517824
12protein localization to synapse (GO:0035418)5.03344841
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01591869
14* ionotropic glutamate receptor signaling pathway (GO:0035235)4.85810317
15neurotransmitter-gated ion channel clustering (GO:0072578)4.77003592
16glutamate secretion (GO:0014047)4.68165092
17regulation of synaptic vesicle exocytosis (GO:2000300)4.66483608
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.58274140
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57658193
20exploration behavior (GO:0035640)4.55599569
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50814603
22regulation of neuronal synaptic plasticity (GO:0048168)4.37851095
23* glutamate receptor signaling pathway (GO:0007215)4.33448435
24neurotransmitter secretion (GO:0007269)4.30046478
25* synaptic transmission, glutamatergic (GO:0035249)4.28688896
26regulation of synaptic vesicle transport (GO:1902803)4.20099863
27* neuron-neuron synaptic transmission (GO:0007270)4.13235904
28postsynaptic membrane organization (GO:0001941)4.09973822
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.09249152
30potassium ion import (GO:0010107)4.01799731
31regulation of synapse structural plasticity (GO:0051823)4.01117893
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98662572
33neuronal action potential propagation (GO:0019227)3.98452972
34gamma-aminobutyric acid transport (GO:0015812)3.92295016
35amino acid import (GO:0043090)3.91415725
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.90717489
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.89039437
38presynaptic membrane assembly (GO:0097105)3.86753553
39long-term memory (GO:0007616)3.85430285
40positive regulation of membrane potential (GO:0045838)3.85245542
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.84070396
42cellular potassium ion homeostasis (GO:0030007)3.81701497
43layer formation in cerebral cortex (GO:0021819)3.80441980
44dendritic spine morphogenesis (GO:0060997)3.80437010
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79863680
46transmission of nerve impulse (GO:0019226)3.79378913
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.76575154
48potassium ion homeostasis (GO:0055075)3.74107953
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.72587162
50regulation of postsynaptic membrane potential (GO:0060078)3.72510709
51neuron recognition (GO:0008038)3.66181714
52long-term synaptic potentiation (GO:0060291)3.64380835
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63737302
54mechanosensory behavior (GO:0007638)3.62517013
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60838711
56regulation of synaptic plasticity (GO:0048167)3.58248635
57presynaptic membrane organization (GO:0097090)3.57948123
58neurotransmitter transport (GO:0006836)3.57681975
59auditory behavior (GO:0031223)3.54836963
60positive regulation of synapse maturation (GO:0090129)3.54066793
61response to histamine (GO:0034776)3.52920089
62proline transport (GO:0015824)3.51379142
63response to auditory stimulus (GO:0010996)3.51068540
64synaptic vesicle endocytosis (GO:0048488)3.50990294
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45322501
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.44393379
67regulation of dendritic spine morphogenesis (GO:0061001)3.40634260
68positive regulation of neurotransmitter secretion (GO:0001956)3.39387703
69membrane hyperpolarization (GO:0060081)3.37719309
70prepulse inhibition (GO:0060134)3.35152243
71regulation of neurotransmitter levels (GO:0001505)3.31819924
72regulation of neurotransmitter secretion (GO:0046928)3.31193596
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31073331
74neurotransmitter uptake (GO:0001504)3.31002082
75behavioral defense response (GO:0002209)3.30764171
76behavioral fear response (GO:0001662)3.30764171
77C4-dicarboxylate transport (GO:0015740)3.30010622
78cell migration in hindbrain (GO:0021535)3.28966873
79neuromuscular synaptic transmission (GO:0007274)3.28369305
80positive regulation of neurotransmitter transport (GO:0051590)3.26529700
81learning (GO:0007612)3.25151317
82cerebellar Purkinje cell differentiation (GO:0021702)3.24812830
83axonal fasciculation (GO:0007413)3.21730395
84cellular sodium ion homeostasis (GO:0006883)3.19232376
85sodium ion export (GO:0071436)3.18280632
86acidic amino acid transport (GO:0015800)3.17952107
87neuromuscular process controlling balance (GO:0050885)3.17650783
88synapse assembly (GO:0007416)3.17377294
89cell communication by electrical coupling (GO:0010644)3.17358173
90regulation of synaptic transmission, GABAergic (GO:0032228)3.16892686
91membrane depolarization (GO:0051899)3.16648603
92positive regulation of synaptic transmission (GO:0050806)3.16080871
93adult walking behavior (GO:0007628)3.15460022
94positive regulation of dendritic spine development (GO:0060999)3.12595425
95regulation of neurotransmitter transport (GO:0051588)3.12424408
96L-amino acid import (GO:0043092)3.10191407
97regulation of voltage-gated calcium channel activity (GO:1901385)3.08534527
98regulation of synapse maturation (GO:0090128)3.07746119
99neuromuscular process (GO:0050905)3.07327492
100fear response (GO:0042596)3.06761498
101establishment of mitochondrion localization (GO:0051654)3.05301990
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04854257
103innervation (GO:0060384)3.04844418
104regulation of vesicle fusion (GO:0031338)3.03613247
105neuronal ion channel clustering (GO:0045161)3.03088504
106regulation of synaptic transmission (GO:0050804)3.01799554
107startle response (GO:0001964)3.01789222
108pyrimidine nucleobase catabolic process (GO:0006208)3.01639097
109membrane depolarization during action potential (GO:0086010)3.00961733
110dendrite morphogenesis (GO:0048813)3.00332570
111regulation of glutamate secretion (GO:0014048)3.00305971
112behavioral response to cocaine (GO:0048148)2.99984208
113activation of protein kinase A activity (GO:0034199)2.99747994
114positive regulation of synapse assembly (GO:0051965)2.99446218
115cell differentiation in hindbrain (GO:0021533)2.98791615
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.98249099
117regulation of dendritic spine development (GO:0060998)2.97305816
118cerebellar granule cell differentiation (GO:0021707)2.95460235
119serotonin metabolic process (GO:0042428)2.94998441
120long term synaptic depression (GO:0060292)2.94719162
121* synaptic transmission (GO:0007268)2.94538183
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94117545
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.94030787
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93551675
125glycine transport (GO:0015816)2.93227508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73845928
2GBX2_23144817_ChIP-Seq_PC3_Human3.97751017
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13230562
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07556370
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02751946
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67530188
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67530188
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62549646
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62349653
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60101023
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.57560373
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.56329775
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47604681
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44318954
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43821361
16DROSHA_22980978_ChIP-Seq_HELA_Human2.41380754
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.39657698
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.33953736
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24770813
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.22360960
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.20555084
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09768735
23AR_21572438_ChIP-Seq_LNCaP_Human2.05512443
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04851199
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.02144568
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91585359
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87271091
28TAF15_26573619_Chip-Seq_HEK293_Human1.87146355
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83082884
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82738782
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71530143
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70151489
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68105360
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.66885039
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65934049
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64734650
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57746178
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56885106
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51166878
40P300_19829295_ChIP-Seq_ESCs_Human1.49635393
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42499011
42* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42477288
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41777016
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.40082273
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.38696583
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.36781972
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35802442
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.33287624
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31172305
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30217918
51AR_25329375_ChIP-Seq_VCAP_Human1.30062794
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26467057
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.25409665
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22662214
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22101177
56* STAT3_23295773_ChIP-Seq_U87_Human1.21974118
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20542763
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20373809
59ZNF274_21170338_ChIP-Seq_K562_Hela1.17837297
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17446433
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15313582
62* AR_19668381_ChIP-Seq_PC3_Human1.15046496
63RNF2_27304074_Chip-Seq_NSC_Mouse1.14881368
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12853470
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11807605
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11555170
67* TCF4_23295773_ChIP-Seq_U87_Human1.10981963
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10667349
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.08889951
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08733241
71IGF1R_20145208_ChIP-Seq_DFB_Human1.08120547
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07453607
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06570574
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06267172
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.05912831
76RUNX2_22187159_ChIP-Seq_PCA_Human1.04626230
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.03869089
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03775228
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03730906
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03492201
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00765078
82AHR_22903824_ChIP-Seq_MCF-7_Human1.00342549
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99980548
84VDR_22108803_ChIP-Seq_LS180_Human0.99367245
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98363247
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.98284555
87* FUS_26573619_Chip-Seq_HEK293_Human0.98260371
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.97294142
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97116369
90SOX9_26525672_Chip-Seq_HEART_Mouse0.95458443
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95139825
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95139825
93JUN_21703547_ChIP-Seq_K562_Human0.94587053
94RXR_22108803_ChIP-Seq_LS180_Human0.94520672
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.94444309
96ER_23166858_ChIP-Seq_MCF-7_Human0.92453480
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92191099
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.92062611
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.91938400
100KDM2B_26808549_Chip-Seq_REH_Human0.91745563
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91383603
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90920731
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90201477
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90089054
105BCAT_22108803_ChIP-Seq_LS180_Human0.89705839
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89383890
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88744495
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88590132
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87599368
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87383779
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87361489
112TP53_16413492_ChIP-PET_HCT116_Human0.86867096
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.86290878
114TP53_18474530_ChIP-ChIP_U2OS_Human0.86088239
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84694292
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84358991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23569526
2MP0003880_abnormal_central_pattern5.17048105
3MP0003635_abnormal_synaptic_transmissio4.15230380
4MP0009745_abnormal_behavioral_response3.57862401
5MP0002063_abnormal_learning/memory/cond3.35652343
6MP0004270_analgesia3.34225798
7MP0002822_catalepsy3.24486841
8MP0002064_seizures3.23312001
9MP0005423_abnormal_somatic_nervous3.19130029
10MP0001968_abnormal_touch/_nociception3.15134079
11MP0009046_muscle_twitch3.02983173
12MP0002572_abnormal_emotion/affect_behav2.88036771
13MP0001486_abnormal_startle_reflex2.75940299
14MP0002272_abnormal_nervous_system2.60421099
15MP0002736_abnormal_nociception_after2.58394034
16MP0002734_abnormal_mechanical_nocicepti2.50774708
17MP0001501_abnormal_sleep_pattern2.45386244
18MP0002735_abnormal_chemical_nociception2.21832415
19MP0005646_abnormal_pituitary_gland2.20709618
20MP0001440_abnormal_grooming_behavior2.20558483
21MP0002067_abnormal_sensory_capabilities2.01836316
22MP0002733_abnormal_thermal_nociception1.93791268
23MP0002557_abnormal_social/conspecific_i1.91869264
24MP0001970_abnormal_pain_threshold1.90221546
25MP0002184_abnormal_innervation1.78781149
26MP0006276_abnormal_autonomic_nervous1.77737524
27MP0005386_behavior/neurological_phenoty1.76506528
28MP0004924_abnormal_behavior1.76506528
29MP0000778_abnormal_nervous_system1.73804593
30MP0001984_abnormal_olfaction1.73483392
31MP0009780_abnormal_chondrocyte_physiolo1.72008654
32MP0005645_abnormal_hypothalamus_physiol1.69097632
33MP0008569_lethality_at_weaning1.68351570
34MP0001529_abnormal_vocalization1.62935350
35MP0004858_abnormal_nervous_system1.61336701
36MP0002909_abnormal_adrenal_gland1.61242201
37MP0003329_amyloid_beta_deposits1.61072593
38MP0004811_abnormal_neuron_physiology1.57831394
39MP0003879_abnormal_hair_cell1.56256732
40MP0000955_abnormal_spinal_cord1.51859183
41MP0001502_abnormal_circadian_rhythm1.41940902
42MP0002066_abnormal_motor_capabilities/c1.40059097
43* MP0002882_abnormal_neuron_morphology1.38290612
44MP0003787_abnormal_imprinting1.37706187
45MP0004142_abnormal_muscle_tone1.36644092
46MP0001188_hyperpigmentation1.32789093
47MP0003633_abnormal_nervous_system1.32232901
48* MP0004885_abnormal_endolymph1.30812480
49MP0001905_abnormal_dopamine_level1.27217192
50MP0005551_abnormal_eye_electrophysiolog1.18202412
51MP0004742_abnormal_vestibular_system1.18132202
52MP0003122_maternal_imprinting1.11995609
53MP0003631_nervous_system_phenotype1.06435715
54MP0002152_abnormal_brain_morphology1.05035512
55MP0003690_abnormal_glial_cell1.04456002
56MP0001986_abnormal_taste_sensitivity0.99538103
57MP0010386_abnormal_urinary_bladder0.98584230
58MP0008872_abnormal_physiological_respon0.96937429
59MP0001177_atelectasis0.95994260
60MP0003283_abnormal_digestive_organ0.94025394
61MP0002638_abnormal_pupillary_reflex0.93435756
62MP0003634_abnormal_glial_cell0.92311488
63MP0002069_abnormal_eating/drinking_beha0.91947964
64MP0008874_decreased_physiological_sensi0.91718606
65* MP0002229_neurodegeneration0.91507584
66MP0000566_synostosis0.90661178
67* MP0001963_abnormal_hearing_physiology0.89515779
68MP0000631_abnormal_neuroendocrine_gland0.87690556
69MP0000920_abnormal_myelination0.86686985
70MP0005394_taste/olfaction_phenotype0.84597448
71MP0005499_abnormal_olfactory_system0.84597448
72MP0003136_yellow_coat_color0.83983498
73MP0001485_abnormal_pinna_reflex0.83807567
74MP0006292_abnormal_olfactory_placode0.83794283
75MP0002090_abnormal_vision0.82293306
76MP0005171_absent_coat_pigmentation0.82127433
77MP0004085_abnormal_heartbeat0.81872812
78MP0003938_abnormal_ear_development0.81316703
79MP0008877_abnormal_DNA_methylation0.79603656
80MP0005535_abnormal_body_temperature0.79192551
81MP0005187_abnormal_penis_morphology0.78979186
82* MP0002752_abnormal_somatic_nervous0.77838637
83MP0002249_abnormal_larynx_morphology0.77395295
84MP0005409_darkened_coat_color0.77208150
85MP0003075_altered_response_to0.76909398
86MP0004130_abnormal_muscle_cell0.74930486
87MP0000751_myopathy0.68905439
88MP0001664_abnormal_digestion0.68807952
89MP0004147_increased_porphyrin_level0.68691592
90MP0003632_abnormal_nervous_system0.67742521
91MP0000569_abnormal_digit_pigmentation0.66775403
92MP0000604_amyloidosis0.65987381
93MP0002234_abnormal_pharynx_morphology0.65417256
94MP0004145_abnormal_muscle_electrophysio0.64856847
95MP0002082_postnatal_lethality0.64019462
96MP0005167_abnormal_blood-brain_barrier0.62685504
97MP0003119_abnormal_digestive_system0.62503726
98MP0002876_abnormal_thyroid_physiology0.61146694
99MP0001299_abnormal_eye_distance/0.60991873
100MP0002653_abnormal_ependyma_morphology0.60971798
101MP0010768_mortality/aging0.60860810
102MP0000639_abnormal_adrenal_gland0.59859181
103MP0008961_abnormal_basal_metabolism0.58496311
104MP0004133_heterotaxia0.58230505
105* MP0000026_abnormal_inner_ear0.58192743
106MP0004233_abnormal_muscle_weight0.57769237
107MP0004215_abnormal_myocardial_fiber0.57208513
108MP0003137_abnormal_impulse_conducting0.56557247
109MP0001943_abnormal_respiration0.55848772
110MP0005623_abnormal_meninges_morphology0.55692465
111MP0000013_abnormal_adipose_tissue0.55139419
112MP0005253_abnormal_eye_physiology0.54600799
113MP0003172_abnormal_lysosome_physiology0.53995503
114MP0003045_fibrosis0.52671935
115MP0004484_altered_response_of0.49664121
116MP0003861_abnormal_nervous_system0.49660878
117MP0010769_abnormal_survival0.49411713
118MP0010770_preweaning_lethality0.49076578

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.16563870
2Myokymia (HP:0002411)6.72585384
3Focal seizures (HP:0007359)5.72211279
4Epileptic encephalopathy (HP:0200134)5.04972207
5Visual hallucinations (HP:0002367)4.75174422
6Febrile seizures (HP:0002373)4.73934482
7Atonic seizures (HP:0010819)4.60215678
8Progressive cerebellar ataxia (HP:0002073)4.15492587
9Absence seizures (HP:0002121)4.11492950
10Generalized tonic-clonic seizures (HP:0002069)4.07197996
11Hyperventilation (HP:0002883)3.97880659
12Broad-based gait (HP:0002136)3.80483244
13Dialeptic seizures (HP:0011146)3.78162951
14Action tremor (HP:0002345)3.50612889
15Supranuclear gaze palsy (HP:0000605)3.45694557
16Poor eye contact (HP:0000817)3.39968151
17Dysdiadochokinesis (HP:0002075)3.23583679
18Gaze-evoked nystagmus (HP:0000640)3.20639220
19Depression (HP:0000716)3.10313002
20Abnormal eating behavior (HP:0100738)3.08835271
21Impaired vibration sensation in the lower limbs (HP:0002166)3.03797972
22Impaired social interactions (HP:0000735)3.02641587
23Abnormal social behavior (HP:0012433)3.02641587
24Anxiety (HP:0000739)2.99535623
25Hemiparesis (HP:0001269)2.96445600
26Ankle clonus (HP:0011448)2.95646783
27Mutism (HP:0002300)2.95526001
28Urinary bladder sphincter dysfunction (HP:0002839)2.95359529
29Dysmetria (HP:0001310)2.93303625
30Neurofibrillary tangles (HP:0002185)2.84194496
31Fetal akinesia sequence (HP:0001989)2.81623252
32Postural instability (HP:0002172)2.79583112
33Excessive salivation (HP:0003781)2.79140545
34Drooling (HP:0002307)2.79140545
35Diplopia (HP:0000651)2.77708288
36Abnormality of binocular vision (HP:0011514)2.77708288
37Amblyopia (HP:0000646)2.71020775
38Absent speech (HP:0001344)2.70887791
39Truncal ataxia (HP:0002078)2.68420394
40Torticollis (HP:0000473)2.61986769
41Genetic anticipation (HP:0003743)2.55939293
42Cerebral inclusion bodies (HP:0100314)2.54980034
43Progressive inability to walk (HP:0002505)2.52236877
44Hemiplegia (HP:0002301)2.50820160
45Blue irides (HP:0000635)2.44410544
46Epileptiform EEG discharges (HP:0011182)2.43071352
47Limb dystonia (HP:0002451)2.42207792
48Stereotypic behavior (HP:0000733)2.42128362
49Bradykinesia (HP:0002067)2.40560002
50Focal dystonia (HP:0004373)2.37144276
51Polyphagia (HP:0002591)2.36120100
52Spastic gait (HP:0002064)2.32348553
53EEG with generalized epileptiform discharges (HP:0011198)2.31794895
54Alacrima (HP:0000522)2.30173517
55Papilledema (HP:0001085)2.29330037
56Scanning speech (HP:0002168)2.29321496
57Megalencephaly (HP:0001355)2.26070524
58Urinary urgency (HP:0000012)2.25315627
59Status epilepticus (HP:0002133)2.23932116
60Aplasia involving bones of the extremities (HP:0009825)2.23660967
61Aplasia involving bones of the upper limbs (HP:0009823)2.23660967
62Aplasia of the phalanges of the hand (HP:0009802)2.23660967
63Inability to walk (HP:0002540)2.23611741
64Spastic tetraparesis (HP:0001285)2.21362837
65Impaired smooth pursuit (HP:0007772)2.18220880
66Intention tremor (HP:0002080)2.18067863
67Obstructive sleep apnea (HP:0002870)2.17536385
68Generalized myoclonic seizures (HP:0002123)2.16196424
69Cerebral hypomyelination (HP:0006808)2.14628509
70Increased circulating renin level (HP:0000848)2.14525064
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.12557264
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12557264
73Retinal dysplasia (HP:0007973)2.12513198
74Craniofacial dystonia (HP:0012179)2.12006812
75Hypsarrhythmia (HP:0002521)2.11561447
76Split foot (HP:0001839)2.11380437
77Abnormality of the corticospinal tract (HP:0002492)2.07826869
78Impaired vibratory sensation (HP:0002495)2.06963139
79Hepatoblastoma (HP:0002884)2.06085005
80Incomplete penetrance (HP:0003829)2.05449294
81Abnormality of the lower motor neuron (HP:0002366)2.02843643
82Lower limb muscle weakness (HP:0007340)2.02379816
83Morphological abnormality of the inner ear (HP:0011390)2.01040612
84Hypoplasia of the corpus callosum (HP:0002079)1.97839448
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.97223350
86Absent/shortened dynein arms (HP:0200106)1.97223350
87Insomnia (HP:0100785)1.95212805
88Clonus (HP:0002169)1.94924336
89Abnormality of salivation (HP:0100755)1.93843907
90Morphological abnormality of the pyramidal tract (HP:0002062)1.93138693
91Abnormality of ocular smooth pursuit (HP:0000617)1.92772953
92Gait ataxia (HP:0002066)1.90632395
93Dysmetric saccades (HP:0000641)1.89339598
94Optic nerve hypoplasia (HP:0000609)1.89273786
95Abnormal EKG (HP:0003115)1.88320013
96Spastic tetraplegia (HP:0002510)1.86676724
97Pheochromocytoma (HP:0002666)1.86661162
98Protruding tongue (HP:0010808)1.84131510
99Ventricular fibrillation (HP:0001663)1.83399907
100Sleep apnea (HP:0010535)1.83392871
101Annular pancreas (HP:0001734)1.83373757
102Prolonged QT interval (HP:0001657)1.80643866
103Tetraplegia (HP:0002445)1.80089023
104Delusions (HP:0000746)1.79143379
105Termporal pattern (HP:0011008)1.78414574
106Insidious onset (HP:0003587)1.78414574
107Type II lissencephaly (HP:0007260)1.78224597
108Septo-optic dysplasia (HP:0100842)1.78141915
109Akinesia (HP:0002304)1.77917295
110Inappropriate behavior (HP:0000719)1.76544842
111Amyotrophic lateral sclerosis (HP:0007354)1.76178242
112Oligodactyly (hands) (HP:0001180)1.75235690
113Abnormality of cochlea (HP:0000375)1.72529991
114Agitation (HP:0000713)1.72329410
115Gait imbalance (HP:0002141)1.72311603
116Turricephaly (HP:0000262)1.72064371
117Decreased lacrimation (HP:0000633)1.71644350
118Peripheral hypomyelination (HP:0007182)1.67624484
119Rigidity (HP:0002063)1.66520635
120Hypoventilation (HP:0002791)1.64796099
121Deeply set eye (HP:0000490)1.64403584
122Neoplasm of the peripheral nervous system (HP:0100007)1.63516869
123Ankyloglossia (HP:0010296)1.62370522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.84753301
2NTRK34.51207079
3MAP3K93.26277841
4MARK13.02950235
5CASK3.00818946
6MAP3K42.84592877
7MAP2K72.60266778
8MINK12.53668744
9TNIK2.28710669
10NTRK22.26895402
11DAPK22.23831039
12PAK62.04701604
13RIPK41.99570079
14MAP3K121.92662438
15MAP2K41.78223659
16FES1.67639399
17PRKD31.67114629
18CAMKK11.67068728
19KSR21.62603100
20SIK21.58251849
21NTRK11.57342530
22MAPK131.56953901
23KSR11.53261724
24CDK51.52637626
25PRPF4B1.50170363
26PLK21.49665226
27GRK51.31678465
28DAPK11.29721804
29MAP3K131.29480311
30ARAF1.26589731
31PRKCG1.25239043
32STK381.24077226
33SIK31.15565701
34MAPKAPK51.15370272
35CAMK2A1.11678278
36PNCK1.06786365
37SGK2231.06178490
38SGK4941.06178490
39SGK21.00449775
40PHKG20.99771287
41PHKG10.99771287
42TYRO30.98488845
43BMPR20.97763542
44UHMK10.94260643
45CAMK10.93961942
46CDK190.93936399
47NME10.92263367
48NEK60.88933507
49DYRK20.88371786
50CSNK1G30.82533882
51INSRR0.81324268
52TNK20.80735706
53CSNK1A1L0.79802794
54CAMKK20.79043739
55STK110.78976122
56SGK10.77934793
57CAMK2B0.77305888
58DYRK1A0.76879650
59PINK10.76560557
60CDK180.76061507
61MAP3K20.72731528
62AKT30.72544735
63CDK150.72447961
64MUSK0.72246976
65PRKCH0.71795893
66OXSR10.71692988
67LATS20.71684760
68SGK30.70238513
69TAOK10.69760380
70CDK140.69161907
71FGFR20.66083011
72RAF10.64039909
73MARK20.62590653
74CDK11A0.61977799
75MAP3K10.61200952
76MAP3K110.60268338
77CSNK1G10.60074571
78RIPK10.59978131
79FGR0.59790645
80PRKCE0.59116257
81PTK2B0.59036027
82FRK0.58943042
83PAK30.58310513
84CSNK1G20.56700713
85PRKCZ0.55292452
86STK390.55103235
87MAPK120.53247281
88CAMK40.51185562
89RPS6KA30.50732667
90CAMK1G0.50179396
91PDK10.50122768
92RET0.48563516
93LMTK20.47471891
94WNK40.46100844
95PDPK10.45898322
96TAOK30.45713783
97CAMK2D0.44969332
98MAPK100.44883424
99FYN0.44363817
100PKN10.41932746
101ALK0.41322041
102ADRBK20.41188014
103BRAF0.40415373
104FER0.40385619
105WNK30.40262928
106CSNK1D0.40188214
107CAMK2G0.39751326
108CDC42BPA0.38007338
109PRKACA0.37977802
110ROCK10.37276966
111TSSK60.36057792
112PRKCA0.35879650
113PRKG10.35863050
114ADRBK10.35672193
115MAP2K10.35404613
116PRKCB0.35338402
117BRSK10.34442147
118CCNB10.34106227
119CDK30.34040406
120MAPK150.33177816
121ERBB20.32752757
122WNK10.32672332
123EPHA30.32321532
124RPS6KB10.30498076
125GSK3B0.29817944

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14827358
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25833816
3GABAergic synapse_Homo sapiens_hsa047272.91985466
4Olfactory transduction_Homo sapiens_hsa047402.84495417
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83500419
6Morphine addiction_Homo sapiens_hsa050322.74099931
7Circadian entrainment_Homo sapiens_hsa047132.72687488
8Glutamatergic synapse_Homo sapiens_hsa047242.67433415
9Long-term potentiation_Homo sapiens_hsa047202.51633641
10Amphetamine addiction_Homo sapiens_hsa050312.41628186
11Salivary secretion_Homo sapiens_hsa049702.23292331
12Dopaminergic synapse_Homo sapiens_hsa047282.08623043
13Insulin secretion_Homo sapiens_hsa049111.97160576
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96575737
15Cholinergic synapse_Homo sapiens_hsa047251.90484887
16Taste transduction_Homo sapiens_hsa047421.89165629
17Gastric acid secretion_Homo sapiens_hsa049711.83783530
18Serotonergic synapse_Homo sapiens_hsa047261.81641658
19Cocaine addiction_Homo sapiens_hsa050301.77088151
20Renin secretion_Homo sapiens_hsa049241.76719231
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73598028
22Calcium signaling pathway_Homo sapiens_hsa040201.71553741
23Long-term depression_Homo sapiens_hsa047301.69166054
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58297229
25Collecting duct acid secretion_Homo sapiens_hsa049661.55936057
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54636647
27GnRH signaling pathway_Homo sapiens_hsa049121.40771572
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36240886
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33595796
30Gap junction_Homo sapiens_hsa045401.32753820
31cAMP signaling pathway_Homo sapiens_hsa040241.31842622
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22968600
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20822860
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15253959
35Axon guidance_Homo sapiens_hsa043601.15216560
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09288468
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08652076
38Type II diabetes mellitus_Homo sapiens_hsa049301.08637105
39Glioma_Homo sapiens_hsa052141.05435387
40Estrogen signaling pathway_Homo sapiens_hsa049151.03630912
41Cardiac muscle contraction_Homo sapiens_hsa042601.02098055
42ErbB signaling pathway_Homo sapiens_hsa040120.99879637
43Phototransduction_Homo sapiens_hsa047440.99127197
44Melanogenesis_Homo sapiens_hsa049160.97700829
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93888692
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.92975517
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86339160
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85815339
49Vibrio cholerae infection_Homo sapiens_hsa051100.85597610
50Nitrogen metabolism_Homo sapiens_hsa009100.84409570
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.84116911
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83356146
53Pancreatic secretion_Homo sapiens_hsa049720.81812606
54Dorso-ventral axis formation_Homo sapiens_hsa043200.76139183
55Vitamin B6 metabolism_Homo sapiens_hsa007500.73809422
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73425834
57Choline metabolism in cancer_Homo sapiens_hsa052310.73097601
58Dilated cardiomyopathy_Homo sapiens_hsa054140.72800257
59MAPK signaling pathway_Homo sapiens_hsa040100.68006767
60Histidine metabolism_Homo sapiens_hsa003400.67863730
61Thyroid hormone synthesis_Homo sapiens_hsa049180.65616342
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65487413
63Type I diabetes mellitus_Homo sapiens_hsa049400.65113518
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64549405
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64446577
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63926952
67Ras signaling pathway_Homo sapiens_hsa040140.61128446
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60319692
69Oocyte meiosis_Homo sapiens_hsa041140.57414264
70Butanoate metabolism_Homo sapiens_hsa006500.56241233
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54818905
72Rap1 signaling pathway_Homo sapiens_hsa040150.52495350
73Alcoholism_Homo sapiens_hsa050340.50355999
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50058512
75Inositol phosphate metabolism_Homo sapiens_hsa005620.47848903
76Bile secretion_Homo sapiens_hsa049760.47607428
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.47601378
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47549619
79African trypanosomiasis_Homo sapiens_hsa051430.47212268
80beta-Alanine metabolism_Homo sapiens_hsa004100.46874346
81Circadian rhythm_Homo sapiens_hsa047100.46871543
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.45870298
83Ovarian steroidogenesis_Homo sapiens_hsa049130.44941878
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44158618
85Glucagon signaling pathway_Homo sapiens_hsa049220.43259737
86Wnt signaling pathway_Homo sapiens_hsa043100.41979959
87VEGF signaling pathway_Homo sapiens_hsa043700.41515607
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41241456
89Ether lipid metabolism_Homo sapiens_hsa005650.40865260
90Hippo signaling pathway_Homo sapiens_hsa043900.39767207
91Alzheimers disease_Homo sapiens_hsa050100.38816130
92Prion diseases_Homo sapiens_hsa050200.37945243
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37615033
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37274564
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33918047
96Arginine and proline metabolism_Homo sapiens_hsa003300.33857368
97Rheumatoid arthritis_Homo sapiens_hsa053230.31996946
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31991517
99Endocytosis_Homo sapiens_hsa041440.31979628
100Chemokine signaling pathway_Homo sapiens_hsa040620.31746217
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31270379
102Mineral absorption_Homo sapiens_hsa049780.30666051
103Renal cell carcinoma_Homo sapiens_hsa052110.30137606
104Non-small cell lung cancer_Homo sapiens_hsa052230.29164626
105Endometrial cancer_Homo sapiens_hsa052130.29044252
106ABC transporters_Homo sapiens_hsa020100.26212441
107mTOR signaling pathway_Homo sapiens_hsa041500.26155165
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25720000
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25475510
110Fatty acid biosynthesis_Homo sapiens_hsa000610.25029421
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.24293923
112Hedgehog signaling pathway_Homo sapiens_hsa043400.23214688
113Tight junction_Homo sapiens_hsa045300.21010438

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