GRID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)6.41604060
2locomotory exploration behavior (GO:0035641)5.45539584
3neuronal action potential propagation (GO:0019227)5.44787183
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.39105118
5* cerebellar granule cell differentiation (GO:0021707)5.36439751
6gamma-aminobutyric acid transport (GO:0015812)5.09109196
7* glutamate receptor signaling pathway (GO:0007215)5.02272416
8* ionotropic glutamate receptor signaling pathway (GO:0035235)4.87279387
9vocalization behavior (GO:0071625)4.84651622
10neuron cell-cell adhesion (GO:0007158)4.83328306
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.82017377
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.78304718
13cellular potassium ion homeostasis (GO:0030007)4.69720160
14cerebellar Purkinje cell differentiation (GO:0021702)4.69547505
15cerebellar Purkinje cell layer development (GO:0021680)4.67819727
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54585299
17presynaptic membrane organization (GO:0097090)4.45935091
18response to pheromone (GO:0019236)4.45160927
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43317478
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.43265701
21* synaptic transmission, glutamatergic (GO:0035249)4.38212117
22neurofilament cytoskeleton organization (GO:0060052)4.35460020
23* neuron-neuron synaptic transmission (GO:0007270)4.18862868
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.16992764
25synaptic vesicle exocytosis (GO:0016079)4.16944111
26transmission of nerve impulse (GO:0019226)4.16702942
27presynaptic membrane assembly (GO:0097105)4.15882374
28regulation of posttranscriptional gene silencing (GO:0060147)4.14652581
29regulation of gene silencing by miRNA (GO:0060964)4.14652581
30regulation of gene silencing by RNA (GO:0060966)4.14652581
31neurotransmitter secretion (GO:0007269)4.11402067
32C4-dicarboxylate transport (GO:0015740)4.07810718
33negative regulation of synaptic transmission, GABAergic (GO:0032229)4.05180819
34multicellular organismal movement (GO:0050879)4.03186700
35musculoskeletal movement (GO:0050881)4.03186700
36neurotransmitter-gated ion channel clustering (GO:0072578)4.02953176
37regulation of synaptic vesicle exocytosis (GO:2000300)4.02220264
38central nervous system myelination (GO:0022010)4.01533809
39axon ensheathment in central nervous system (GO:0032291)4.01533809
40synaptic vesicle maturation (GO:0016188)4.01324253
41protein heterotetramerization (GO:0051290)4.00512396
42L-amino acid import (GO:0043092)4.00492080
43sodium ion export (GO:0071436)3.99799518
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92081705
45long-term memory (GO:0007616)3.91248338
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.86626069
47* cell differentiation in hindbrain (GO:0021533)3.85895180
48regulation of glutamate receptor signaling pathway (GO:1900449)3.85724288
49exploration behavior (GO:0035640)3.80537729
50metanephric tubule development (GO:0072170)3.78279886
51metanephric nephron tubule development (GO:0072234)3.78279886
52glutamate secretion (GO:0014047)3.74253453
53collecting duct development (GO:0072044)3.71829344
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67793926
55regulation of centriole replication (GO:0046599)3.67583541
56innervation (GO:0060384)3.67208244
57adult walking behavior (GO:0007628)3.66666636
58retina layer formation (GO:0010842)3.63507422
59behavioral response to nicotine (GO:0035095)3.58865931
60positive regulation of synapse assembly (GO:0051965)3.58464714
61amino acid import (GO:0043090)3.57467535
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51015892
63retinal cone cell development (GO:0046549)3.50269152
64protein localization to synapse (GO:0035418)3.49766323
65neurotransmitter transport (GO:0006836)3.49619390
66positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.48531284
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45043764
68establishment of integrated proviral latency (GO:0075713)3.44289252
69layer formation in cerebral cortex (GO:0021819)3.43822735
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.43264927
71regulation of synaptic vesicle transport (GO:1902803)3.42349247
72postsynaptic membrane organization (GO:0001941)3.40988506
73positive regulation of synapse maturation (GO:0090129)3.39516051
74neuromuscular process controlling posture (GO:0050884)3.39119279
75negative regulation of neurotransmitter transport (GO:0051589)3.39077250
76metanephric nephron epithelium development (GO:0072243)3.37273416
77regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35952199
78auditory behavior (GO:0031223)3.35063759
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32222196
80* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30663520
81potassium ion import (GO:0010107)3.29825946
82membrane hyperpolarization (GO:0060081)3.27805853
83dendrite morphogenesis (GO:0048813)3.27033758
84positive regulation of membrane potential (GO:0045838)3.26931454
85mechanosensory behavior (GO:0007638)3.25776866
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25479757
87regulation of neurotransmitter levels (GO:0001505)3.25251116
88synapse assembly (GO:0007416)3.24927933
89pre-miRNA processing (GO:0031054)3.24427702
90cochlea development (GO:0090102)3.24208225
91dendritic spine morphogenesis (GO:0060997)3.22893698
92positive regulation of potassium ion transmembrane transport (GO:1901381)3.22664739
93neuron recognition (GO:0008038)3.21907518
94response to auditory stimulus (GO:0010996)3.21205230
95neuromuscular process controlling balance (GO:0050885)3.19162810
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19114616
97long-term synaptic potentiation (GO:0060291)3.17423408
98* regulation of postsynaptic membrane potential (GO:0060078)3.16001604
99glycine transport (GO:0015816)3.14743785
100potassium ion homeostasis (GO:0055075)3.14112707
101regulation of neuronal synaptic plasticity (GO:0048168)3.12438434
102regulation of neurotransmitter secretion (GO:0046928)3.10951861
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10738336
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08972884
105membrane depolarization during action potential (GO:0086010)3.07467923
106acidic amino acid transport (GO:0015800)3.06322805
107axonal fasciculation (GO:0007413)3.06079623
108negative regulation of norepinephrine secretion (GO:0010700)3.06065834
109regulation of voltage-gated calcium channel activity (GO:1901385)3.05933695
110metanephric epithelium development (GO:0072207)3.04649134
111long term synaptic depression (GO:0060292)2.99824895
112negative regulation of neurotransmitter secretion (GO:0046929)2.99167294
113neurotransmitter uptake (GO:0001504)2.98865663
114response to histamine (GO:0034776)2.98512912
115neuronal ion channel clustering (GO:0045161)2.96061964
116proline transport (GO:0015824)2.95859983
117regulation of neurotransmitter transport (GO:0051588)2.94872850
118* membrane depolarization (GO:0051899)2.94150489
119synaptic vesicle endocytosis (GO:0048488)2.93440493
120regulation of beta-amyloid formation (GO:1902003)2.93278336
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91569691
122cell communication by electrical coupling (GO:0010644)2.91207311
123cellular sodium ion homeostasis (GO:0006883)2.90057126
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88734748
125synapse organization (GO:0050808)2.88142072
126negative regulation of translation, ncRNA-mediated (GO:0040033)2.86843902
127regulation of translation, ncRNA-mediated (GO:0045974)2.86843902
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86843902
129L-glutamate transport (GO:0015813)2.85915022
130regulation of vesicle fusion (GO:0031338)2.85573670
131learning (GO:0007612)2.85087461
132righting reflex (GO:0060013)2.83639313
133fructose metabolic process (GO:0006000)2.82846045
134chromatin remodeling at centromere (GO:0031055)2.77632045
135negative regulation of heart rate (GO:0010459)2.76864607
136lung-associated mesenchyme development (GO:0060484)2.76164079
137regulation of potassium ion transmembrane transporter activity (GO:1901016)2.72969667
138protein complex localization (GO:0031503)2.72199348
139serotonin metabolic process (GO:0042428)2.71070787
140histone exchange (GO:0043486)2.69055314
141L-serine metabolic process (GO:0006563)2.68887101
142CENP-A containing nucleosome assembly (GO:0034080)2.63583870
143negative regulation of catecholamine secretion (GO:0033604)2.63103992
144positive regulation of muscle hypertrophy (GO:0014742)2.58095871
145positive regulation of cardiac muscle hypertrophy (GO:0010613)2.58095871
146inositol phosphate-mediated signaling (GO:0048016)2.57866428
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.56813058
148regulation of histone H3-K9 methylation (GO:0051570)2.51066537
149auditory receptor cell stereocilium organization (GO:0060088)2.51023636
150atrial cardiac muscle cell action potential (GO:0086014)2.50144173
151relaxation of smooth muscle (GO:0044557)2.49944164
152adult behavior (GO:0030534)2.49805621
153negative regulation of cell fate commitment (GO:0010454)2.46604532
154regulation of potassium ion transmembrane transport (GO:1901379)2.45861341
155establishment of viral latency (GO:0019043)2.38806680
156regulation of synaptic transmission, GABAergic (GO:0032228)2.38530316
157negative regulation of DNA-dependent DNA replication (GO:2000104)2.38461545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20965104
2GBX2_23144817_ChIP-Seq_PC3_Human3.76013270
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13297605
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00072769
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88089352
6VDR_22108803_ChIP-Seq_LS180_Human2.71853631
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66397615
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66397615
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57545178
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55776196
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46360949
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46062923
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45396461
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.43238498
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38440072
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38133298
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.37476446
18DROSHA_22980978_ChIP-Seq_HELA_Human2.37311519
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34712109
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32069352
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30712931
22* EZH2_27304074_Chip-Seq_ESCs_Mouse2.26185825
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19236316
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15305836
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14686031
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14686031
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14686031
28* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06775791
29AR_21572438_ChIP-Seq_LNCaP_Human2.06370126
30E2F7_22180533_ChIP-Seq_HELA_Human2.05522245
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02082788
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96507379
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95223145
34* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84651285
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.84528786
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.82097391
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81634251
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.76576093
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73155160
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.72613015
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72384930
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70050701
43* EWS_26573619_Chip-Seq_HEK293_Human1.69306359
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64851245
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64137138
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63439516
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60039405
48* TAF15_26573619_Chip-Seq_HEK293_Human1.59806185
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58283158
50* SOX2_16153702_ChIP-ChIP_HESCs_Human1.56800856
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56437671
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.54193520
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.51996900
54* P300_19829295_ChIP-Seq_ESCs_Human1.51931231
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51824419
56ZNF274_21170338_ChIP-Seq_K562_Hela1.48605711
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46624173
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45552554
59* PIAS1_25552417_ChIP-Seq_VCAP_Human1.43092729
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42389375
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41767785
62* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41261324
63STAT3_23295773_ChIP-Seq_U87_Human1.39707971
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36840006
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36512257
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31212803
67SOX9_26525672_Chip-Seq_HEART_Mouse1.30741659
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.30359762
69* AR_25329375_ChIP-Seq_VCAP_Human1.30287389
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.29299143
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.28561658
72* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28203726
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28076565
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26666751
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.26640800
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25005771
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.24414235
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23709331
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23587444
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22470149
81TP53_16413492_ChIP-PET_HCT116_Human1.21383842
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21287131
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21064306
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20796139
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20549029
86* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20432243
87ER_23166858_ChIP-Seq_MCF-7_Human1.20170569
88TCF4_23295773_ChIP-Seq_U87_Human1.19960163
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19417522
90* AR_19668381_ChIP-Seq_PC3_Human1.16883769
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14285632
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14285632
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.13639408
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.12703048
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.12378835
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11422661
97RNF2_27304074_Chip-Seq_NSC_Mouse1.10820490
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09618283
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.09395079
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08746296
101IGF1R_20145208_ChIP-Seq_DFB_Human1.08663347
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07927517
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07643612
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07311378
105* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07210264
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07142362
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.06841331
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06505758
109* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06341349
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05831188
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05713002
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05661974
113JUN_21703547_ChIP-Seq_K562_Human1.05117206
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04955416
115* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03669088
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03298040
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03279441
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02414015
119AHR_22903824_ChIP-Seq_MCF-7_Human1.02267723
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02136633
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01204191
122FUS_26573619_Chip-Seq_HEK293_Human1.00351154
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00251046
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00200507
125* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99985161
126* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99435488
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.99393228
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99371762
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99052471
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98627400
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96858355
132* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96061173
133BCAT_22108803_ChIP-Seq_LS180_Human0.95493729
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.94217999
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.92697891
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92171342
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90830070
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.89960729
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.89865773
140* TP53_18474530_ChIP-ChIP_U2OS_Human0.89023712
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88409471
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88182270
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88032252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.75117197
2* MP0009046_muscle_twitch4.06172188
3MP0003880_abnormal_central_pattern3.92148543
4* MP0003635_abnormal_synaptic_transmissio3.80785039
5MP0009745_abnormal_behavioral_response3.30921950
6MP0004270_analgesia3.19041857
7MP0002064_seizures3.16052150
8MP0002272_abnormal_nervous_system3.10473812
9MP0005423_abnormal_somatic_nervous2.98642781
10MP0001968_abnormal_touch/_nociception2.82043184
11* MP0002063_abnormal_learning/memory/cond2.80595719
12MP0001486_abnormal_startle_reflex2.78317893
13* MP0002572_abnormal_emotion/affect_behav2.66964891
14MP0002734_abnormal_mechanical_nocicepti2.66743425
15MP0008877_abnormal_DNA_methylation2.65885208
16MP0003941_abnormal_skin_development2.65263859
17* MP0008569_lethality_at_weaning2.58585587
18* MP0002067_abnormal_sensory_capabilities2.47683134
19MP0004145_abnormal_muscle_electrophysio2.44603017
20MP0002736_abnormal_nociception_after2.41007614
21* MP0001440_abnormal_grooming_behavior2.39145830
22MP0004142_abnormal_muscle_tone2.24136861
23MP0001501_abnormal_sleep_pattern2.20575904
24MP0010386_abnormal_urinary_bladder2.16312895
25MP0002735_abnormal_chemical_nociception2.10197591
26MP0003329_amyloid_beta_deposits2.05551531
27MP0004885_abnormal_endolymph1.99298636
28* MP0002184_abnormal_innervation1.94688689
29MP0004924_abnormal_behavior1.93594609
30MP0005386_behavior/neurological_phenoty1.93594609
31MP0001970_abnormal_pain_threshold1.90929591
32MP0002733_abnormal_thermal_nociception1.90872114
33MP0000778_abnormal_nervous_system1.87668168
34MP0003690_abnormal_glial_cell1.87183361
35MP0005171_absent_coat_pigmentation1.86830507
36MP0001984_abnormal_olfaction1.78074107
37* MP0002557_abnormal_social/conspecific_i1.75723512
38* MP0000920_abnormal_myelination1.70831466
39MP0001529_abnormal_vocalization1.68989081
40* MP0004742_abnormal_vestibular_system1.61155710
41MP0002254_reproductive_system_inflammat1.60117048
42MP0000955_abnormal_spinal_cord1.59245323
43MP0003136_yellow_coat_color1.57621119
44MP0001502_abnormal_circadian_rhythm1.55401981
45MP0003632_abnormal_nervous_system1.55309490
46* MP0002066_abnormal_motor_capabilities/c1.54403845
47MP0003890_abnormal_embryonic-extraembry1.54298263
48MP0005645_abnormal_hypothalamus_physiol1.53358212
49MP0003633_abnormal_nervous_system1.45477657
50MP0003631_nervous_system_phenotype1.43810283
51* MP0002882_abnormal_neuron_morphology1.43643129
52MP0000566_synostosis1.39285487
53MP0003693_abnormal_embryo_hatching1.37725406
54MP0002822_catalepsy1.36255919
55* MP0006035_abnormal_mitochondrial_morpho1.33767203
56MP0004858_abnormal_nervous_system1.33270223
57MP0008058_abnormal_DNA_repair1.32528576
58MP0004147_increased_porphyrin_level1.30672724
59MP0004957_abnormal_blastocyst_morpholog1.30138682
60MP0008057_abnormal_DNA_replication1.29922087
61MP0003121_genomic_imprinting1.27957361
62MP0009672_abnormal_birth_weight1.27056988
63MP0001188_hyperpigmentation1.25250298
64MP0005551_abnormal_eye_electrophysiolog1.25220443
65MP0001485_abnormal_pinna_reflex1.24021625
66MP0003634_abnormal_glial_cell1.23548187
67MP0006276_abnormal_autonomic_nervous1.22717183
68MP0005646_abnormal_pituitary_gland1.21251505
69MP0003119_abnormal_digestive_system1.17577837
70* MP0002229_neurodegeneration1.17096660
71MP0003011_delayed_dark_adaptation1.17001841
72MP0003718_maternal_effect1.16279455
73* MP0002152_abnormal_brain_morphology1.16169547
74MP0001905_abnormal_dopamine_level1.15881069
75MP0003567_abnormal_fetal_cardiomyocyte1.15612874
76MP0004811_abnormal_neuron_physiology1.14818861
77MP0006292_abnormal_olfactory_placode1.13780469
78MP0004133_heterotaxia1.13262669
79MP0003123_paternal_imprinting1.12255499
80MP0003879_abnormal_hair_cell1.10984799
81MP0001963_abnormal_hearing_physiology1.09115352
82MP0000579_abnormal_nail_morphology1.09050520
83MP0004043_abnormal_pH_regulation1.06884987
84MP0010094_abnormal_chromosome_stability1.05212398
85MP0008932_abnormal_embryonic_tissue1.03536690
86MP0009780_abnormal_chondrocyte_physiolo1.03062002
87MP0004215_abnormal_myocardial_fiber1.01787089
88MP0003111_abnormal_nucleus_morphology1.01702259
89MP0001293_anophthalmia0.97818767
90MP0001299_abnormal_eye_distance/0.96625241
91MP0002697_abnormal_eye_size0.95708207
92MP0002752_abnormal_somatic_nervous0.93887675
93MP0003937_abnormal_limbs/digits/tail_de0.93088864
94MP0008872_abnormal_physiological_respon0.91152283
95MP0000604_amyloidosis0.91009260
96MP0003137_abnormal_impulse_conducting0.90898052
97MP0003122_maternal_imprinting0.87291765
98MP0000537_abnormal_urethra_morphology0.83944003
99MP0006072_abnormal_retinal_apoptosis0.83706593
100MP0002102_abnormal_ear_morphology0.82172639
101MP0002751_abnormal_autonomic_nervous0.81700100
102MP0001177_atelectasis0.81177010
103MP0003077_abnormal_cell_cycle0.80104638
104MP0009697_abnormal_copulation0.77433745
105MP0003787_abnormal_imprinting0.77425625
106* MP0002069_abnormal_eating/drinking_beha0.76992637
107MP0005623_abnormal_meninges_morphology0.76984460
108MP0005409_darkened_coat_color0.76956686
109MP0004085_abnormal_heartbeat0.74961313
110MP0008875_abnormal_xenobiotic_pharmacok0.73202466
111MP0005187_abnormal_penis_morphology0.70552122
112MP0000751_myopathy0.70457922
113MP0004484_altered_response_of0.69797978
114* MP0003698_abnormal_male_reproductive0.68933676
115MP0000631_abnormal_neuroendocrine_gland0.68532188
116MP0000026_abnormal_inner_ear0.68196013
117MP0003878_abnormal_ear_physiology0.67744935
118MP0005377_hearing/vestibular/ear_phenot0.67744935
119MP0009703_decreased_birth_body0.67523700
120MP0005620_abnormal_muscle_contractility0.67509474
121MP0005253_abnormal_eye_physiology0.65520075
122MP0002638_abnormal_pupillary_reflex0.64968529
123MP0002909_abnormal_adrenal_gland0.63851829
124MP0008874_decreased_physiological_sensi0.62826820
125MP0000013_abnormal_adipose_tissue0.61809813
126MP0003045_fibrosis0.61249188
127MP0001943_abnormal_respiration0.59677061
128MP0002089_abnormal_postnatal_growth/wei0.59659857
129* MP0010769_abnormal_survival0.57400363
130MP0005535_abnormal_body_temperature0.55635877
131* MP0010770_preweaning_lethality0.55232088
132* MP0002082_postnatal_lethality0.55232088
133* MP0010768_mortality/aging0.54008501
134MP0000747_muscle_weakness0.53678381
135* MP0003861_abnormal_nervous_system0.53349467
136MP0002090_abnormal_vision0.52257284
137MP0004036_abnormal_muscle_relaxation0.52047199
138MP0005499_abnormal_olfactory_system0.51019963
139MP0005394_taste/olfaction_phenotype0.51019963

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.88189027
2Progressive cerebellar ataxia (HP:0002073)6.13445607
3Action tremor (HP:0002345)5.89443316
4Focal seizures (HP:0007359)5.23390545
5Myokymia (HP:0002411)4.98275877
6Gaze-evoked nystagmus (HP:0000640)4.82080706
7Atonic seizures (HP:0010819)4.71481137
8Visual hallucinations (HP:0002367)4.58274552
9Scanning speech (HP:0002168)4.51064835
10Epileptic encephalopathy (HP:0200134)4.50666044
11Dysdiadochokinesis (HP:0002075)4.49637845
12Febrile seizures (HP:0002373)4.29545917
13Broad-based gait (HP:0002136)4.15198710
14Dysmetria (HP:0001310)3.91738359
15Intention tremor (HP:0002080)3.82393433
16Absence seizures (HP:0002121)3.79337737
17Hemiparesis (HP:0001269)3.73314309
18Abnormality of the labia minora (HP:0012880)3.70389497
19Truncal ataxia (HP:0002078)3.62262780
20Dialeptic seizures (HP:0011146)3.59754758
21Abnormality of binocular vision (HP:0011514)3.57963027
22Diplopia (HP:0000651)3.57963027
23Hemiplegia (HP:0002301)3.44008433
24Generalized tonic-clonic seizures (HP:0002069)3.33531784
25Dysmetric saccades (HP:0000641)3.31600114
26Impaired smooth pursuit (HP:0007772)3.23914841
27Abnormality of the corticospinal tract (HP:0002492)3.16694044
28Genetic anticipation (HP:0003743)3.14955224
29Neurofibrillary tangles (HP:0002185)3.05469917
30Hyperventilation (HP:0002883)3.04577422
31Abnormality of ocular smooth pursuit (HP:0000617)3.01225687
32Supranuclear gaze palsy (HP:0000605)2.92162275
33Septo-optic dysplasia (HP:0100842)2.84651244
34Postural tremor (HP:0002174)2.83818574
35Abnormal eating behavior (HP:0100738)2.83458329
36Colon cancer (HP:0003003)2.81327916
37Status epilepticus (HP:0002133)2.66332754
38Aplasia involving bones of the extremities (HP:0009825)2.64677858
39Aplasia involving bones of the upper limbs (HP:0009823)2.64677858
40Aplasia of the phalanges of the hand (HP:0009802)2.64677858
41Poor eye contact (HP:0000817)2.62988828
42Abnormality of saccadic eye movements (HP:0000570)2.58233310
43Anxiety (HP:0000739)2.57079515
44Spastic gait (HP:0002064)2.51823801
45Depression (HP:0000716)2.49242043
46Postural instability (HP:0002172)2.48783712
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47227539
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.47227539
49Excessive salivation (HP:0003781)2.47075843
50Drooling (HP:0002307)2.47075843
51Pheochromocytoma (HP:0002666)2.41677786
52Impaired social interactions (HP:0000735)2.39032494
53Abnormal social behavior (HP:0012433)2.39032494
54Absent speech (HP:0001344)2.37171201
55Spastic diplegia (HP:0001264)2.37019418
56Tetraplegia (HP:0002445)2.35064331
57Cerebral inclusion bodies (HP:0100314)2.30237121
58Limb ataxia (HP:0002070)2.29788697
59Hepatoblastoma (HP:0002884)2.26888030
60Megalencephaly (HP:0001355)2.26167986
61Ankle clonus (HP:0011448)2.25385907
62Impaired vibration sensation in the lower limbs (HP:0002166)2.25166824
63Gait ataxia (HP:0002066)2.25166312
64Peripheral hypomyelination (HP:0007182)2.24522499
65Horizontal nystagmus (HP:0000666)2.23616294
66Oligodactyly (hands) (HP:0001180)2.23346591
67Acute necrotizing encephalopathy (HP:0006965)2.23337967
68Blue irides (HP:0000635)2.23319438
69Split foot (HP:0001839)2.21249886
70Optic nerve hypoplasia (HP:0000609)2.14702723
71Fetal akinesia sequence (HP:0001989)2.14415679
72Cortical dysplasia (HP:0002539)2.14209246
73Mutism (HP:0002300)2.14071125
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13447292
75Choanal stenosis (HP:0000452)2.10281695
76Neuroendocrine neoplasm (HP:0100634)2.09010489
77Epileptiform EEG discharges (HP:0011182)2.07923843
78Humeroradial synostosis (HP:0003041)2.07285159
79Synostosis involving the elbow (HP:0003938)2.07285159
80Urinary bladder sphincter dysfunction (HP:0002839)2.06974253
81Progressive inability to walk (HP:0002505)2.06290360
82Insidious onset (HP:0003587)2.06150438
83Termporal pattern (HP:0011008)2.06150438
84EEG with generalized epileptiform discharges (HP:0011198)2.05954635
85Neuronal loss in central nervous system (HP:0002529)2.04324169
86Cutaneous finger syndactyly (HP:0010554)2.01430336
87Agitation (HP:0000713)2.01040059
88Retinal dysplasia (HP:0007973)1.99362949
89Bilateral microphthalmos (HP:0007633)1.99063983
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.98616442
91Stereotypic behavior (HP:0000733)1.98394981
92Psychosis (HP:0000709)1.98227377
93Morphological abnormality of the pyramidal tract (HP:0002062)1.96236935
94Cutaneous syndactyly (HP:0012725)1.95575524
95Birth length less than 3rd percentile (HP:0003561)1.94786911
96Hypsarrhythmia (HP:0002521)1.92629528
97Absent/shortened dynein arms (HP:0200106)1.92417689
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.92417689
99Progressive macrocephaly (HP:0004481)1.92250054
100Acute encephalopathy (HP:0006846)1.91472019
101Annular pancreas (HP:0001734)1.91222771
102Clumsiness (HP:0002312)1.90693796
103Aqueductal stenosis (HP:0002410)1.87212907
104Polyphagia (HP:0002591)1.87178398
105Leukodystrophy (HP:0002415)1.85229289
106Confusion (HP:0001289)1.84973680
107Abnormal ciliary motility (HP:0012262)1.84840148
108Bradykinesia (HP:0002067)1.84697826
109Limb dystonia (HP:0002451)1.84497854
110Lower limb asymmetry (HP:0100559)1.84439138
111Slow progression (HP:0003677)1.83447874
112Abnormal mitochondria in muscle tissue (HP:0008316)1.81087090
113Absent septum pellucidum (HP:0001331)1.80827278
114Narrow nasal bridge (HP:0000446)1.80175792
115Nephroblastoma (Wilms tumor) (HP:0002667)1.79234380
116Lower limb muscle weakness (HP:0007340)1.79063822
117Generalized myoclonic seizures (HP:0002123)1.79006461
118Medulloblastoma (HP:0002885)1.78577306
119Incomplete penetrance (HP:0003829)1.77525532
120Urinary urgency (HP:0000012)1.76666167
121Increased hepatocellular lipid droplets (HP:0006565)1.76065939
122Abnormality of the septum pellucidum (HP:0007375)1.75715849
123Agnosia (HP:0010524)1.74620858
124Anteriorly placed anus (HP:0001545)1.73890790
125Esotropia (HP:0000565)1.73633404
126Impaired vibratory sensation (HP:0002495)1.72944646
127Hyperglycinemia (HP:0002154)1.72469524
128Abnormal lung lobation (HP:0002101)1.72323291
129Specific learning disability (HP:0001328)1.72004900
130Hypoglycemic seizures (HP:0002173)1.71227005
131Ependymoma (HP:0002888)1.68454169
132Esophageal atresia (HP:0002032)1.67671705
133Embryonal renal neoplasm (HP:0011794)1.65279829
134Chronic bronchitis (HP:0004469)1.63933176
135Glioma (HP:0009733)1.61118835
136Inability to walk (HP:0002540)1.59330810
137Genital tract atresia (HP:0001827)1.59182742
138Labial hypoplasia (HP:0000066)1.57909414
139Hypoplastic female external genitalia (HP:0012815)1.57778349
140Vaginal atresia (HP:0000148)1.57665406
141Abnormal hair whorl (HP:0010721)1.54515974
142Abnormality of serum amino acid levels (HP:0003112)1.53961306
143Maternal diabetes (HP:0009800)1.53181099
144Sleep apnea (HP:0010535)1.50995210
145Bifid tongue (HP:0010297)1.50638149
146Hyperinsulinemic hypoglycemia (HP:0000825)1.50531574
147Abnormality of the astrocytes (HP:0100707)1.49441289
148Astrocytoma (HP:0009592)1.49441289
149Cerebellar atrophy (HP:0001272)1.49414905
150Short hallux (HP:0010109)1.47628732
151Lipid accumulation in hepatocytes (HP:0006561)1.45536648
152Aplasia/Hypoplasia of the hallux (HP:0008362)1.44688802
153Dysphonia (HP:0001618)1.41720079
154Broad foot (HP:0001769)1.40331024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK63.66377011
2NTRK33.61889521
3TTK3.32522934
4CASK3.25861016
5TNIK2.93879014
6NTRK22.75191136
7MAP3K42.66613476
8CAMKK22.66422188
9CDC72.45403061
10MAP3K92.44716860
11PNCK2.41481035
12MARK12.38434083
13MKNK22.34613497
14MAP2K72.24182891
15BUB12.22729763
16MINK12.18459191
17TAF12.08048987
18PRPF4B2.06259528
19OXSR12.06176983
20WNK12.01748579
21CDK191.88322370
22EPHA41.86652439
23ZAK1.80184105
24PAK61.79606915
25PLK31.77081720
26MKNK11.73850982
27PLK41.73561883
28CSNK1G11.67097136
29MAPK131.65197331
30MAP2K41.63788476
31STK391.62838214
32SGK2231.51341651
33SGK4941.51341651
34DAPK21.51122917
35SRPK11.49700678
36CAMKK11.49361556
37PHKG21.41294955
38PHKG11.41294955
39TYRO31.38524588
40DYRK21.34006458
41PRKCG1.30708567
42CDK51.29853930
43BCR1.29133452
44UHMK11.27607317
45NTRK11.27373951
46RIPK41.26472211
47KSR11.24231323
48VRK21.23206993
49SGK21.20411959
50WEE11.18782321
51SIK21.15783971
52VRK11.15478605
53FES1.15248304
54STK381.12758853
55CAMK2B1.12601948
56CAMK1G1.11913569
57PKN11.11742125
58PLK21.10819107
59CAMK2A1.10645480
60RIPK11.09554474
61PLK11.08093205
62TRIM281.07982901
63NEK61.03608183
64SIK31.02017805
65ARAF1.01294740
66CAMK2G1.00038197
67MAPKAPK50.99239976
68MAP3K120.98058699
69MAP3K130.96492994
70LATS20.95027967
71BMPR1B0.92141421
72KSR20.91232511
73CAMK2D0.91195573
74FGFR20.89587911
75CDK180.88883058
76CHEK20.88212730
77NEK10.88028580
78ROCK20.87403953
79CDK150.85839638
80CAMK10.85763227
81PINK10.85334490
82SGK30.83848880
83STK110.83778080
84GRK50.83571543
85CAMK1D0.81241020
86NUAK10.80114302
87CDK140.79595223
88SGK10.79417396
89PRKG20.78889583
90BRSK20.76318933
91EPHB10.76117402
92CSNK1E0.74255119
93CDK11A0.73523976
94PRKDC0.73404841
95PRKCH0.73334283
96PRKG10.72764848
97PRKD30.72600715
98DAPK10.70539837
99PRKCE0.70478240
100MUSK0.70266282
101DYRK1A0.69032086
102PBK0.68869311
103MARK20.67826507
104BRAF0.67093839
105BMPR20.66759085
106STK38L0.66584412
107NME10.65976881
108PAK30.64359448
109TNK20.64358565
110ERBB40.63764353
111CSNK1G20.63454479
112FGFR10.59579708
113MAP3K100.59012008
114FGR0.58368802
115CAMK40.58315008
116INSRR0.57823484
117RPS6KA30.54965638
118CSNK1D0.54537737
119PAK40.54184171
120LMTK20.53776637
121CDC42BPA0.53667356
122DYRK30.53616721
123FYN0.53563266
124PRKACA0.53072729
125PDPK10.52756911
126ATM0.52609278
127PDK10.51867817
128CDK30.51545770
129ATR0.51143206
130CDK10.46915713
131AKT30.46673715
132RET0.46480323
133EIF2AK20.45973774
134WNK30.44415595
135CSNK1A1L0.41513891
136BRSK10.41412276
137CSNK1A10.40958625
138ALK0.40811358
139PRKACB0.40763846
140PRKCZ0.39673847
141MAPK100.38631478
142GRK70.38111674
143PRKCB0.38048211
144PTK60.37796102
145ADRBK20.37279223
146CSNK1G30.36694237
147LATS10.36217438

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.55032165
2Glutamatergic synapse_Homo sapiens_hsa047243.10444230
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.06084273
4GABAergic synapse_Homo sapiens_hsa047272.94629981
5Circadian entrainment_Homo sapiens_hsa047132.63079905
6Long-term potentiation_Homo sapiens_hsa047202.61023394
7Morphine addiction_Homo sapiens_hsa050322.60430312
8Synaptic vesicle cycle_Homo sapiens_hsa047212.58832197
9Taste transduction_Homo sapiens_hsa047422.38849173
10* Long-term depression_Homo sapiens_hsa047302.32827244
11Salivary secretion_Homo sapiens_hsa049702.32244714
12Amphetamine addiction_Homo sapiens_hsa050312.04784400
13Olfactory transduction_Homo sapiens_hsa047401.88743502
14Gastric acid secretion_Homo sapiens_hsa049711.87960291
15Dopaminergic synapse_Homo sapiens_hsa047281.85933114
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81593821
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81449331
18Serotonergic synapse_Homo sapiens_hsa047261.79747966
19Insulin secretion_Homo sapiens_hsa049111.68097614
20Cholinergic synapse_Homo sapiens_hsa047251.64304176
21Calcium signaling pathway_Homo sapiens_hsa040201.60271829
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59588224
23Renin secretion_Homo sapiens_hsa049241.54731235
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40174341
25Oxytocin signaling pathway_Homo sapiens_hsa049211.38005968
26Cocaine addiction_Homo sapiens_hsa050301.35860401
27Mismatch repair_Homo sapiens_hsa034301.34396631
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32703896
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31343300
30Gap junction_Homo sapiens_hsa045401.29376064
31Pancreatic secretion_Homo sapiens_hsa049721.26761642
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26420038
33cAMP signaling pathway_Homo sapiens_hsa040241.25712274
34Collecting duct acid secretion_Homo sapiens_hsa049661.22892809
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22279337
36Cardiac muscle contraction_Homo sapiens_hsa042601.21092988
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19806651
38GnRH signaling pathway_Homo sapiens_hsa049121.16858748
39RNA polymerase_Homo sapiens_hsa030201.10123990
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.09836937
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07693054
42Axon guidance_Homo sapiens_hsa043601.05634815
43Vitamin B6 metabolism_Homo sapiens_hsa007501.03342593
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03219196
45Type II diabetes mellitus_Homo sapiens_hsa049301.03183505
46Pyruvate metabolism_Homo sapiens_hsa006201.02210896
47Non-homologous end-joining_Homo sapiens_hsa034501.02180560
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01181288
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99479244
50Estrogen signaling pathway_Homo sapiens_hsa049150.99290560
51Biosynthesis of amino acids_Homo sapiens_hsa012300.96819139
52Thyroid hormone synthesis_Homo sapiens_hsa049180.95466089
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95172712
54DNA replication_Homo sapiens_hsa030300.95043267
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93937702
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.92869912
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91918481
58Nitrogen metabolism_Homo sapiens_hsa009100.90440665
59Protein export_Homo sapiens_hsa030600.90402895
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.90231911
61Dorso-ventral axis formation_Homo sapiens_hsa043200.84899715
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84578012
63Melanogenesis_Homo sapiens_hsa049160.83064112
64Cell cycle_Homo sapiens_hsa041100.81692353
65Basal transcription factors_Homo sapiens_hsa030220.80327038
66Alzheimers disease_Homo sapiens_hsa050100.79830209
67RNA transport_Homo sapiens_hsa030130.79144692
68Proteasome_Homo sapiens_hsa030500.79035225
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76318874
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76121709
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75845781
72Fatty acid biosynthesis_Homo sapiens_hsa000610.75584899
73ErbB signaling pathway_Homo sapiens_hsa040120.74948851
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74233836
75Selenocompound metabolism_Homo sapiens_hsa004500.73740523
76Bile secretion_Homo sapiens_hsa049760.72718115
77Choline metabolism in cancer_Homo sapiens_hsa052310.72527242
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70411350
79Ether lipid metabolism_Homo sapiens_hsa005650.69879114
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69582436
81Dilated cardiomyopathy_Homo sapiens_hsa054140.68487805
82Oxidative phosphorylation_Homo sapiens_hsa001900.68375624
83Inositol phosphate metabolism_Homo sapiens_hsa005620.67910030
84Tight junction_Homo sapiens_hsa045300.67460531
85Propanoate metabolism_Homo sapiens_hsa006400.65685180
86Pentose phosphate pathway_Homo sapiens_hsa000300.65069413
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64899005
88mRNA surveillance pathway_Homo sapiens_hsa030150.63116299
89Carbon metabolism_Homo sapiens_hsa012000.62790129
90Spliceosome_Homo sapiens_hsa030400.62478168
91Phototransduction_Homo sapiens_hsa047440.61704960
92Circadian rhythm_Homo sapiens_hsa047100.61206344
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61154466
94Vibrio cholerae infection_Homo sapiens_hsa051100.60536896
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60441173
96Homologous recombination_Homo sapiens_hsa034400.60056193
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59858707
98Steroid biosynthesis_Homo sapiens_hsa001000.59324823
99Hippo signaling pathway_Homo sapiens_hsa043900.58109153
100MAPK signaling pathway_Homo sapiens_hsa040100.57777044
101Glioma_Homo sapiens_hsa052140.57691989
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.57203248
103Mineral absorption_Homo sapiens_hsa049780.57186590
104Oocyte meiosis_Homo sapiens_hsa041140.56560204
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56540689
106Butanoate metabolism_Homo sapiens_hsa006500.52893437
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.51761876
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50516253
109RNA degradation_Homo sapiens_hsa030180.50254679
110Renin-angiotensin system_Homo sapiens_hsa046140.50074570
111Ovarian steroidogenesis_Homo sapiens_hsa049130.49823517
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47941196
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46210029
114Ras signaling pathway_Homo sapiens_hsa040140.43951379
115One carbon pool by folate_Homo sapiens_hsa006700.42591391
116Fatty acid elongation_Homo sapiens_hsa000620.42265856
117Fructose and mannose metabolism_Homo sapiens_hsa000510.42179921
118Sphingolipid metabolism_Homo sapiens_hsa006000.41784320
119Adherens junction_Homo sapiens_hsa045200.41142954
120Folate biosynthesis_Homo sapiens_hsa007900.40201556
121Glycerolipid metabolism_Homo sapiens_hsa005610.39724566
122African trypanosomiasis_Homo sapiens_hsa051430.38752288
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37889705
124Hedgehog signaling pathway_Homo sapiens_hsa043400.36338501
125Fanconi anemia pathway_Homo sapiens_hsa034600.35847949
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35841318
127Renal cell carcinoma_Homo sapiens_hsa052110.35542089
128Rap1 signaling pathway_Homo sapiens_hsa040150.35038577
129Purine metabolism_Homo sapiens_hsa002300.35018788
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34412978
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34327819
132Alcoholism_Homo sapiens_hsa050340.33731988
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33417576
134Parkinsons disease_Homo sapiens_hsa050120.33099455
135Wnt signaling pathway_Homo sapiens_hsa043100.31697160
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30093336
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29903501
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26469767
139Huntingtons disease_Homo sapiens_hsa050160.26072848
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24141174

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