ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to muscle activity (GO:0014850)	9.66970331
2	visual perception (GO:0007601)	8.93261116
3	sensory perception of light stimulus (GO:0050953)	8.82368989
4	camera-type eye development (GO:0043010)	7.93747995
5	cytolysis (GO:0019835)	7.82910431
6	protein refolding (GO:0042026)	7.64981883
7	histone H3-K9 demethylation (GO:0033169)	7.50835066
8	muscle cell cellular homeostasis (GO:0046716)	6.93755830
9	cellular response to osmotic stress (GO:0071470)	6.65436295
10	regulation of protein sumoylation (GO:0033233)	6.43512235
11	eye development (GO:0001654)	6.40150748
12	bile acid and bile salt transport (GO:0015721)	6.03980769
13	myofibril assembly (GO:0030239)	5.90156386
14	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	5.06171645
15	sensory organ development (GO:0007423)	4.89352517
16	response to salt stress (GO:0009651)	4.58349187
17	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.42412857
18	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.34900818
19	insulin-like growth factor receptor signaling pathway (GO:0048009)	4.33896260
20	sarcomere organization (GO:0045214)	4.26744924
21	protoporphyrinogen IX metabolic process (GO:0046501)	4.26638344
22	sensory perception (GO:0007600)	4.03454433
23	lens development in camera-type eye (GO:0002088)	35.5522929
24	regulation of myoblast differentiation (GO:0045661)	3.91245675
25	regulation of platelet aggregation (GO:0090330)	3.74226311
26	protein homotrimerization (GO:0070207)	3.71850812
27	regulation of Rac protein signal transduction (GO:0035020)	3.36963890
28	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.23256150
29	positive regulation of calcium ion transport into cytosol (GO:0010524)	3.19427102
30	regulation of skeletal muscle fiber development (GO:0048742)	3.08066997
31	water transport (GO:0006833)	3.06595707
32	lens fiber cell development (GO:0070307)	25.7024417
33	lens fiber cell differentiation (GO:0070306)	20.7741596
34	cellular response to calcium ion (GO:0071277)	2.99263153
35	histone lysine demethylation (GO:0070076)	2.96613522
36	porphyrin-containing compound biosynthetic process (GO:0006779)	2.92005236
37	lung epithelium development (GO:0060428)	2.91841264
38	positive regulation of wound healing (GO:0090303)	2.81965960
39	histone demethylation (GO:0016577)	2.78493184
40	heme biosynthetic process (GO:0006783)	2.70496338
41	fluid transport (GO:0042044)	2.60835728
42	protein demethylation (GO:0006482)	2.58112164
43	protein dealkylation (GO:0008214)	2.58112164
44	activation of JUN kinase activity (GO:0007257)	2.52505995
45	respiratory tube development (GO:0030323)	2.51956443
46	intermediate filament cytoskeleton organization (GO:0045104)	2.48760871
47	tetrapyrrole biosynthetic process (GO:0033014)	2.47339085
48	regulation of myotube differentiation (GO:0010830)	2.46961633
49	L-alpha-amino acid transmembrane transport (GO:1902475)	2.43175439
50	response to activity (GO:0014823)	2.41453238
51	intermediate filament-based process (GO:0045103)	2.37405078
52	apoptotic process involved in morphogenesis (GO:0060561)	2.30586215
53	negative regulation of cell size (GO:0045792)	2.29909765
54	actomyosin structure organization (GO:0031032)	2.28780724
55	negative regulation of platelet activation (GO:0010544)	2.25359807
56	erythrocyte maturation (GO:0043249)	2.22664177
57	epithelial cell development (GO:0002064)	2.22021080
58	regulation of translational termination (GO:0006449)	2.20733552
59	dopaminergic neuron differentiation (GO:0071542)	2.20678674
60	regulation of release of sequestered calcium ion into cytosol (GO:0051279)	2.19995387
61	regulation of homotypic cell-cell adhesion (GO:0034110)	2.19944638
62	skeletal muscle organ development (GO:0060538)	2.18677067
63	apoptotic process involved in development (GO:1902742)	2.17154630
64	porphyrin-containing compound metabolic process (GO:0006778)	2.17046490
65	regulation of uterine smooth muscle contraction (GO:0070472)	2.14704282
66	negative regulation of norepinephrine secretion (GO:0010700)	2.13978810
67	response to osmotic stress (GO:0006970)	2.10136134
68	heme metabolic process (GO:0042168)	2.07614740
69	actin filament capping (GO:0051693)	2.04557722
70	cerebellar granule cell differentiation (GO:0021707)	2.03254735
71	lens morphogenesis in camera-type eye (GO:0002089)	10.0184698
72	hemoglobin metabolic process (GO:0020027)	1.98676696
73	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.95377992
74	collecting duct development (GO:0072044)	1.94175861
75	positive regulation of cell cycle checkpoint (GO:1901978)	1.93397356
76	cell maturation (GO:0048469)	1.89015455
77	cell-cell junction assembly (GO:0007043)	1.87651177
78	neuronal stem cell maintenance (GO:0097150)	1.87475137
79	regulation of gamma-delta T cell differentiation (GO:0045586)	1.87392134
80	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.86854777
81	viral transcription (GO:0019083)	1.86567809
82	3-UTR-mediated mRNA stabilization (GO:0070935)	1.84039856
83	diaphragm development (GO:0060539)	1.83412238
84	protein trimerization (GO:0070206)	1.81741976
85	lipopolysaccharide biosynthetic process (GO:0009103)	1.81184155
86	lung-associated mesenchyme development (GO:0060484)	1.81063165
87	positive regulation of dendritic spine development (GO:0060999)	1.79931037
88	ventricular septum morphogenesis (GO:0060412)	1.79391218
89	mating behavior (GO:0007617)	1.78602803
90	negative T cell selection (GO:0043383)	1.77931911
91	positive regulation of dendrite morphogenesis (GO:0050775)	1.77380631
92	negative regulation of JUN kinase activity (GO:0043508)	1.76956385
93	protein localization to cell surface (GO:0034394)	1.75957587
94	translational termination (GO:0006415)	1.75253354
95	negative thymic T cell selection (GO:0045060)	1.70955616
96	positive thymic T cell selection (GO:0045059)	1.68143919
97	cellular response to prostaglandin stimulus (GO:0071379)	1.67963412
98	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	1.67009735
99	regulation of striated muscle cell differentiation (GO:0051153)	1.66942288
100	positive T cell selection (GO:0043368)	1.66847007

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	9.90400630
2	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	5.35348341
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.15044368
4	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.65941113
5	EGR1_19032775_ChIP-ChIP_M12_Human	3.31560149
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.18322447
7	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.17042767
8	MYC_22102868_ChIP-Seq_BL_Human	2.87783406
9	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.55031795
10	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.54495026
11	GATA1_22025678_ChIP-Seq_K562_Human	2.44215976
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.30046301
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.09625902
14	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.07016563
15	NANOG_16153702_ChIP-ChIP_HESCs_Human	2.06990646
16	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	2.05439827
17	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.89760388
18	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.84388365
19	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.81407281
20	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.80236984
21	LXR_22292898_ChIP-Seq_THP-1_Human	1.78881084
22	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.78349856
23	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.73777335
24	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.70735353
25	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.68259470
26	GATA1_19941826_ChIP-Seq_K562_Human	1.65418083
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.63796671
28	KDM2B_26808549_Chip-Seq_DND41_Human	1.59513065
29	* TCF7_22412390_ChIP-Seq_EML_Mouse	1.55630706
30	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.55030452
31	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.52372916
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50898610
33	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.50522257
34	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.49082004
35	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.48817817
36	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.47896513
37	CTCF_27219007_Chip-Seq_Bcells_Human	1.46891903
38	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.43415379
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.40805344
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32303154
41	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.31755558
42	CTCF_21964334_Chip-Seq_Bcells_Human	1.31633916
43	KDM2B_26808549_Chip-Seq_K562_Human	1.30178878
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.29987493
45	MAF_26560356_Chip-Seq_TH2_Human	1.28975402
46	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.27387276
47	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.25244290
48	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.24992310
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24407496
50	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.22790051
51	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.16941434
52	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.16111324
53	* GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.16002022
54	UTX_26944678_Chip-Seq_JUKART_Human	1.15720943
55	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.15155453
56	* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.15053038
57	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.14993757
58	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14702560
59	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.13467261
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12755907
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12755907
62	MAF_26560356_Chip-Seq_TH1_Human	1.12069817
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11605429
64	VDR_21846776_ChIP-Seq_THP-1_Human	1.10998423
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.10003345
66	P68_20966046_ChIP-Seq_HELA_Human	1.09624943
67	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08843752
68	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.07254382
69	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.04906641
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03238068
71	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.01942447
72	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.01343165
73	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.01003373
74	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.99416464
75	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98791079
76	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.98135473
77	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.97104968
78	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.95902011
79	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.94959732
80	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.94628569
81	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.93974846
82	OCT4_19829295_ChIP-Seq_ESCs_Human	0.93429165
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92445885
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92136427
85	MYB_26560356_Chip-Seq_TH2_Human	0.91963712
86	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91555462
87	GATA2_19941826_ChIP-Seq_K562_Human	0.91402193
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.90514905
89	RUNX_20019798_ChIP-Seq_JUKART_Human	0.88066729
90	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.85241768
91	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.84407392
92	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.83980165
93	* SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.83174526
94	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.82247833
95	SCL_19346495_ChIP-Seq_HPC-7_Human	0.82142613
96	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.81504772
97	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.81231382
98	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.80952109
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.80912435
100	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.80628393

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005193_abnormal_anterior_eye	9.02105724
2	MP0005253_abnormal_eye_physiology	4.94205859
3	MP0000749_muscle_degeneration	3.87259574
4	MP0001286_abnormal_eye_development	3.83137982
5	MP0002092_abnormal_eye_morphology	3.67288289
6	MP0005197_abnormal_uvea_morphology	3.59557039
7	MP0005391_vision/eye_phenotype	3.15384529
8	MP0003941_abnormal_skin_development	3.04317104
9	MP0003656_abnormal_erythrocyte_physiolo	2.59115793
10	MP0002090_abnormal_vision	2.08103990
11	MP0001346_abnormal_lacrimal_gland	2.01068608
12	MP0002697_abnormal_eye_size	14.0923847
13	MP0004147_increased_porphyrin_level	1.80271004
14	MP0002638_abnormal_pupillary_reflex	1.59883316
15	MP0005330_cardiomyopathy	1.49293765
16	MP0002269_muscular_atrophy	1.41018417
17	MP0002108_abnormal_muscle_morphology	1.26013977
18	MP0005195_abnormal_posterior_eye	1.14587487
19	MP0004272_abnormal_basement_membrane	1.04731217
20	MP0002735_abnormal_chemical_nociception	0.95518434
21	MP0001299_abnormal_eye_distance/	0.93137959
22	MP0001340_abnormal_eyelid_morphology	0.88149755
23	MP0010368_abnormal_lymphatic_system	0.86912922
24	MP0003705_abnormal_hypodermis_morpholog	0.86492996
25	MP0009053_abnormal_anal_canal	0.81100471
26	MP0005551_abnormal_eye_electrophysiolog	0.72418921
27	MP0002653_abnormal_ependyma_morphology	0.71556828
28	MP0001905_abnormal_dopamine_level	0.69373247
29	MP0004087_abnormal_muscle_fiber	0.67854838
30	MP0002139_abnormal_hepatobiliary_system	0.63102682
31	MP0003123_paternal_imprinting	0.62167218
32	MP0005319_abnormal_enzyme/_coenzyme	0.59894257
33	MP0000049_abnormal_middle_ear	0.58312918
34	MP0002089_abnormal_postnatal_growth/wei	0.56017211
35	MP0000759_abnormal_skeletal_muscle	0.51509306
36	MP0001915_intracranial_hemorrhage	0.49155817
37	MP0002163_abnormal_gland_morphology	0.49072690
38	MP0005369_muscle_phenotype	0.49045049
39	MP0004859_abnormal_synaptic_plasticity	0.46932707
40	MP0003763_abnormal_thymus_physiology	0.45415077
41	MP0003329_amyloid_beta_deposits	0.42660219
42	MP0003115_abnormal_respiratory_system	0.41754337
43	MP0005083_abnormal_biliary_tract	0.39774825
44	MP0004197_abnormal_fetal_growth/weight/	0.39411427
45	MP0000685_abnormal_immune_system	0.38012320
46	MP0002398_abnormal_bone_marrow	0.37653575
47	MP0004885_abnormal_endolymph	0.36312152
48	MP0001784_abnormal_fluid_regulation	0.35449314
49	MP0008770_decreased_survivor_rate	0.35398955
50	MP0004811_abnormal_neuron_physiology	0.34613748
51	MP0001730_embryonic_growth_arrest	0.34475411
52	MP0005636_abnormal_mineral_homeostasis	0.34387049
53	MP0006292_abnormal_olfactory_placode	0.34133526
54	MP0000747_muscle_weakness	0.33974641
55	MP0000465_gastrointestinal_hemorrhage	0.33617992
56	MP0004510_myositis	0.32206343
57	MP0002925_abnormal_cardiovascular_devel	0.31660452
58	MP0000703_abnormal_thymus_morphology	0.30391454
59	MP0000428_abnormal_craniofacial_morphol	0.30375874
60	MP0003077_abnormal_cell_cycle	0.29939883
61	MP0008007_abnormal_cellular_replicative	0.29848037
62	MP0002734_abnormal_mechanical_nocicepti	0.28758780
63	MP0002722_abnormal_immune_system	0.28545733
64	MP0001943_abnormal_respiration	0.28049482
65	MP0004957_abnormal_blastocyst_morpholog	0.28039652
66	MP0002736_abnormal_nociception_after	0.27196934
67	MP0003787_abnormal_imprinting	0.27135841
68	MP0005187_abnormal_penis_morphology	0.25762539
69	MP0002086_abnormal_extraembryonic_tissu	0.25545325
70	MP0002249_abnormal_larynx_morphology	0.25387158
71	MP0010307_abnormal_tumor_latency	0.25285615
72	MP0000266_abnormal_heart_morphology	0.24483015
73	MP0005076_abnormal_cell_differentiation	0.24329865
74	MP0003111_abnormal_nucleus_morphology	0.23947255
75	MP0002152_abnormal_brain_morphology	0.23097297
76	MP0009703_decreased_birth_body	0.23030581
77	MP0002177_abnormal_outer_ear	0.21482336
78	MP0002080_prenatal_lethality	0.21479054
79	MP0000350_abnormal_cell_proliferation	0.21397336
80	MP0002429_abnormal_blood_cell	0.21384222
81	MP0002877_abnormal_melanocyte_morpholog	0.21332717
82	MP0003942_abnormal_urinary_system	0.20576105
83	MP0009672_abnormal_birth_weight	0.20521025
84	MP0000604_amyloidosis	0.20499108
85	MP0001968_abnormal_touch/_nociception	0.20212573
86	MP0004185_abnormal_adipocyte_glucose	0.20139359
87	MP0003635_abnormal_synaptic_transmissio	0.20033356
88	MP0002933_joint_inflammation	0.19595168
89	MP0003252_abnormal_bile_duct	0.18981061
90	MP0008872_abnormal_physiological_respon	0.18620112
91	MP0000689_abnormal_spleen_morphology	0.18616968
92	MP0001614_abnormal_blood_vessel	0.17960714
93	MP0000001_mammalian_phenotype	0.17483060
94	MP0002088_abnormal_embryonic_growth/wei	0.17403913
95	MP0003861_abnormal_nervous_system	0.17364708
96	MP0004858_abnormal_nervous_system	0.17143050
97	MP0003984_embryonic_growth_retardation	0.16787632
98	MP0005647_abnormal_sex_gland	0.16771129
99	MP0000955_abnormal_spinal_cord	0.16105963
100	MP0000537_abnormal_urethra_morphology	0.16013216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital cataract (HP:0000519)	7.86549995
2	Corneal dystrophy (HP:0001131)	7.05348011
3	Amblyopia (HP:0000646)	6.91518632
4	Anterior segment dysgenesis (HP:0007700)	5.87590363
5	Polar cataract (HP:0010696)	4.27222558
6	Clumsiness (HP:0002312)	3.84339591
7	Microcornea (HP:0000482)	3.62699091
8	Eosinophilia (HP:0001880)	3.05372737
9	Nuclear cataract (HP:0100018)	27.4410175
10	Zonular cataract (HP:0010920)	24.3298244
11	Iris coloboma (HP:0000612)	2.89101196
12	Opacification of the corneal stroma (HP:0007759)	2.49742029
13	Granulocytopenia (HP:0001913)	2.48779858
14	Abnormality of the anterior chamber (HP:0000593)	2.45814843
15	Sclerocornea (HP:0000647)	2.31312182
16	Abnormality of eosinophils (HP:0001879)	2.18064458
17	Proximal amyotrophy (HP:0007126)	2.04314744
18	Scapular winging (HP:0003691)	1.98800841
19	Congenital primary aphakia (HP:0007707)	1.96988436
20	Posterior subcapsular cataract (HP:0007787)	1.92321333
21	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72312974
22	Aplasia/Hypoplasia of the macula (HP:0008059)	1.69054701
23	Long clavicles (HP:0000890)	1.62977623
24	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.56660753
25	Neonatal respiratory distress (HP:0002643)	1.50777282
26	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.45655324
27	Leukocytosis (HP:0001974)	1.44988225
28	Popliteal pterygium (HP:0009756)	1.44044917
29	Fetal akinesia sequence (HP:0001989)	1.42915277
30	Aplasia of the musculature (HP:0100854)	1.41619477
31	Amniotic constriction ring (HP:0009775)	1.39924391
32	Abnormality of placental membranes (HP:0011409)	1.39924391
33	Hypoplastic nipples (HP:0002557)	1.21380117
34	Abnormality of the shoulder girdle musculature (HP:0001435)	1.21349717
35	Difficulty walking (HP:0002355)	1.20982323
36	Rib fusion (HP:0000902)	1.20291667
37	Akinesia (HP:0002304)	1.16194956
38	Fused cervical vertebrae (HP:0002949)	1.00792501
39	Symphalangism affecting the phalanges of the hand (HP:0009773)	0.98112629
40	Reticulocytosis (HP:0001923)	0.96255641
41	Subcapsular cataract (HP:0000523)	0.91290734
42	Poikilocytosis (HP:0004447)	0.91264234
43	Vertebral clefting (HP:0008428)	0.89681890
44	Abnormality of the labia majora (HP:0012881)	0.88137785
45	Aplasia/Hypoplasia involving the musculature (HP:0001460)	0.86884517
46	Abnormal number of incisors (HP:0011064)	0.84671402
47	Malignant hyperthermia (HP:0002047)	0.83543532
48	Severe visual impairment (HP:0001141)	0.80241955
49	Chorioretinal coloboma (HP:0000567)	0.79064100
50	Ependymoma (HP:0002888)	0.77408325
51	Abnormal number of erythroid precursors (HP:0012131)	0.76818063
52	Exostoses (HP:0100777)	0.74184458
53	Thin ribs (HP:0000883)	0.73609465
54	Abnormality of cells of the erythroid lineage (HP:0012130)	0.71158406
55	Pterygium (HP:0001059)	0.71108742
56	Patellar aplasia (HP:0006443)	0.70198151
57	Neoplasm of the heart (HP:0100544)	0.64873007
58	Aplasia/Hypoplasia of the nipples (HP:0006709)	0.64279030
59	Aplasia/Hypoplasia of the patella (HP:0006498)	0.62136902
60	Dislocated radial head (HP:0003083)	0.62001981
61	Camptodactyly of toe (HP:0001836)	0.61236754
62	Abnormality of reticulocytes (HP:0004312)	0.59709926
63	Pointed chin (HP:0000307)	0.59470210
64	Cystic hygroma (HP:0000476)	0.59384208
65	Hypoplastic pelvis (HP:0008839)	0.58999322
66	Insomnia (HP:0100785)	0.58945954
67	Paralysis (HP:0003470)	0.58193235
68	Hypoplastic heart (HP:0001961)	0.57950561
69	Lymphangioma (HP:0100764)	0.57927211
70	Abnormality of the radial head (HP:0003995)	0.56838040
71	Broad nasal tip (HP:0000455)	0.54634017
72	Abnormality of the humeroradial joint (HP:0100744)	0.52778123
73	Seborrheic dermatitis (HP:0001051)	0.51850528
74	Autosomal dominant inheritance (HP:0000006)	0.51583706
75	Hyperbilirubinemia (HP:0002904)	0.50517393
76	Cholelithiasis (HP:0001081)	0.49940206
77	Annular pancreas (HP:0001734)	0.49770244
78	Abnormality of the astrocytes (HP:0100707)	0.49458347
79	Astrocytoma (HP:0009592)	0.49458347
80	Split foot (HP:0001839)	0.48847477
81	Adenoma sebaceum (HP:0009720)	0.47823032
82	Angiofibromas (HP:0010615)	0.47823032
83	Acanthocytosis (HP:0001927)	0.47078186
84	Abnormality of cochlea (HP:0000375)	0.45353698
85	Hepatocellular carcinoma (HP:0001402)	0.44820665
86	Hemiplegia (HP:0002301)	0.44524460
87	Neonatal hypoglycemia (HP:0001998)	0.44163266
88	Abnormal gallbladder morphology (HP:0012437)	0.43771314
89	Hamartoma of the eye (HP:0010568)	0.42766911
90	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	0.42584715
91	Joint contractures involving the joints of the feet (HP:0100492)	0.42411753
92	Flexion contracture of toe (HP:0005830)	0.42411753
93	Diminished movement (HP:0002374)	0.42045560
94	Vertebral arch anomaly (HP:0008438)	0.41690730
95	Abnormalities of placenta or umbilical cord (HP:0001194)	0.41260618
96	Hepatoblastoma (HP:0002884)	0.39275760
97	Enlarged kidneys (HP:0000105)	0.38669671
98	Hypochromic microcytic anemia (HP:0004840)	0.38122981
99	Muscle fiber splitting (HP:0003555)	0.37087537
100	Porencephaly (HP:0002132)	0.36661833

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K6	7.54616403
2	BLK	5.43139864
3	SGK1	3.76721872
4	MST4	2.91340766
5	MAP3K10	2.80506492
6	WNK4	2.60077166
7	STK10	2.59054382
8	ZAP70	2.58880663
9	PKN2	2.38281284
10	FLT3	2.37905528
11	PRKG1	2.23983444
12	TRIB3	2.17379178
13	NTRK1	2.03752809
14	SIK1	2.02858444
15	STK39	1.96530922
16	LRRK2	1.88607555
17	MAP4K1	1.84257910
18	PRKCB	1.49663969
19	KDR	1.48910236
20	INSR	1.37136104
21	SCYL2	1.32099570
22	IGF1R	1.31822521
23	MAPK10	1.18122240
24	NME2	1.12937427
25	BUB1	1.11918479
26	CDK6	1.08454917
27	PDGFRA	1.03575557
28	ICK	1.02803834
29	BRSK1	0.98251070
30	PRPF4B	0.95865936
31	PRKCQ	0.95739829
32	EIF2AK1	0.95508387
33	RPS6KA3	0.92262140
34	GRK6	0.91503469
35	ERBB2	0.89570480
36	PRKACB	0.89083003
37	JAK3	0.87008208
38	MET	0.84156556
39	ILK	0.81345335
40	WNK1	0.79868097
41	UHMK1	0.79481417
42	PAK4	0.79272585
43	SGK223	0.78726962
44	SGK494	0.78726962
45	ROCK2	0.76632928
46	CDC7	0.72142648
47	SYK	0.71950746
48	TESK2	0.68512927
49	CDK4	0.65484169
50	PRKCH	0.63824803
51	PRKACG	0.61695022
52	STK4	0.61510778
53	CSF1R	0.59283413
54	EPHB2	0.59041297
55	EEF2K	0.58916950
56	MAPKAPK2	0.58613617
57	CSNK2A2	0.55894557
58	ROCK1	0.54396016
59	ITK	0.53282954
60	PTK6	0.53102825
61	NEK1	0.52241036
62	RPS6KA2	0.51963294
63	RPS6KL1	0.51740526
64	RPS6KC1	0.51740526
65	PNCK	0.51296745
66	NEK2	0.48701277
67	MARK3	0.47977486
68	MAP3K8	0.47100755
69	RPS6KA1	0.45372335
70	PKN1	0.44686809
71	CDK12	0.42767230
72	IKBKE	0.41202791
73	PIM1	0.39494880
74	FGFR3	0.38833513
75	RPS6KA6	0.38400140
76	NTRK2	0.38245299
77	TBK1	0.37240368
78	LCK	0.36928972
79	MKNK1	0.36193334
80	HIPK2	0.36122968
81	PTK2	0.35479499
82	ALK	0.34429351
83	CAMKK1	0.34426976
84	AURKA	0.33861762
85	LIMK1	0.32062081
86	CDK1	0.30867601
87	CLK1	0.29905777
88	CDK14	0.29414960
89	PDGFRB	0.28719390
90	TXK	0.28023637
91	BMX	0.27484814
92	CDK15	0.26832035
93	FGFR1	0.26670035
94	ADRBK1	0.26202405
95	CDK11A	0.25582919
96	MAPK9	0.25046652
97	CDK5	0.24928271
98	MINK1	0.24805353
99	TRPM7	0.24647599
100	AKT2	0.24270978

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	3.64018499
2	Small cell lung cancer_Homo sapiens_hsa05222	3.03984929
3	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.42755119
4	Ribosome_Homo sapiens_hsa03010	2.26418139
5	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.24290952
6	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	2.12945175
7	Basal cell carcinoma_Homo sapiens_hsa05217	2.06708549
8	Adherens junction_Homo sapiens_hsa04520	1.95698802
9	Thyroid cancer_Homo sapiens_hsa05216	1.85444843
10	mTOR signaling pathway_Homo sapiens_hsa04150	1.82332025
11	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.82305105
12	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.77643579
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.62251309
14	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.57108783
15	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.55406083
16	Melanogenesis_Homo sapiens_hsa04916	1.53350511
17	Wnt signaling pathway_Homo sapiens_hsa04310	1.49973622
18	mRNA surveillance pathway_Homo sapiens_hsa03015	1.47214309
19	Proteasome_Homo sapiens_hsa03050	1.47187771
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.42313222
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.42180779
22	Non-small cell lung cancer_Homo sapiens_hsa05223	1.40886469
23	Bladder cancer_Homo sapiens_hsa05219	1.39540570
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.38958516
25	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.38776265
26	Spliceosome_Homo sapiens_hsa03040	1.36435799
27	Glioma_Homo sapiens_hsa05214	1.36362442
28	Sulfur relay system_Homo sapiens_hsa04122	1.31511267
29	Insulin signaling pathway_Homo sapiens_hsa04910	1.24711807
30	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.21497318
31	HTLV-I infection_Homo sapiens_hsa05166	1.20007624
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.17575088
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.15572383
34	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.15334970
35	Colorectal cancer_Homo sapiens_hsa05210	1.11804952
36	Proteoglycans in cancer_Homo sapiens_hsa05205	1.11014481
37	Endometrial cancer_Homo sapiens_hsa05213	1.06748029
38	Pathways in cancer_Homo sapiens_hsa05200	1.06558723
39	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.05216593
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01533521
41	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.00533497
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98047335
43	Hippo signaling pathway_Homo sapiens_hsa04390	0.97866832
44	Renal cell carcinoma_Homo sapiens_hsa05211	0.96700379
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96002840
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.94019677
47	Long-term potentiation_Homo sapiens_hsa04720	0.92158231
48	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.92085116
49	Endocytosis_Homo sapiens_hsa04144	0.90910734
50	Olfactory transduction_Homo sapiens_hsa04740	0.90323953
51	Pancreatic cancer_Homo sapiens_hsa05212	0.89355842
52	Toxoplasmosis_Homo sapiens_hsa05145	0.88840812
53	RNA transport_Homo sapiens_hsa03013	0.85766856
54	Cell cycle_Homo sapiens_hsa04110	0.85664997
55	MicroRNAs in cancer_Homo sapiens_hsa05206	0.85416187
56	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.84412235
57	Notch signaling pathway_Homo sapiens_hsa04330	0.83109761
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.82191762
59	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.79813773
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.79586320
61	Glucagon signaling pathway_Homo sapiens_hsa04922	0.79024962
62	Viral myocarditis_Homo sapiens_hsa05416	0.74992558
63	Insulin resistance_Homo sapiens_hsa04931	0.70168408
64	Tight junction_Homo sapiens_hsa04530	0.68262813
65	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.68119127
66	Acute myeloid leukemia_Homo sapiens_hsa05221	0.68050868
67	AMPK signaling pathway_Homo sapiens_hsa04152	0.68009946
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67529448
69	Prion diseases_Homo sapiens_hsa05020	0.65544130
70	Oocyte meiosis_Homo sapiens_hsa04114	0.65272745
71	Axon guidance_Homo sapiens_hsa04360	0.64598638
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61929983
73	Focal adhesion_Homo sapiens_hsa04510	0.59121333
74	One carbon pool by folate_Homo sapiens_hsa00670	0.58771845
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58430346
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.57184846
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.55729760
78	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.55338197
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54602378
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53937743
81	Circadian entrainment_Homo sapiens_hsa04713	0.52931295
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52752186
83	p53 signaling pathway_Homo sapiens_hsa04115	0.52009855
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51851768
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.50882133
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.50019204
87	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49924221
88	Bile secretion_Homo sapiens_hsa04976	0.49617263
89	Gap junction_Homo sapiens_hsa04540	0.49426650
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48899816
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.48218619
92	VEGF signaling pathway_Homo sapiens_hsa04370	0.47481536
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46733784
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46000592
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45220714
96	Carbon metabolism_Homo sapiens_hsa01200	0.44957204
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.44629723
98	ErbB signaling pathway_Homo sapiens_hsa04012	0.40439300
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.39877144
100	Legionellosis_Homo sapiens_hsa05134	0.39532875

GRIFIN

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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