GRIK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)5.38956892
2postsynaptic membrane organization (GO:0001941)4.77020339
3presynaptic membrane assembly (GO:0097105)4.71419914
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71204698
5facial nerve structural organization (GO:0021612)4.70615882
6exploration behavior (GO:0035640)4.57518018
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.28842583
8cellular potassium ion homeostasis (GO:0030007)4.19316044
9presynaptic membrane organization (GO:0097090)4.16330250
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.14193211
11sodium ion export (GO:0071436)4.04017142
12neuronal action potential propagation (GO:0019227)4.03534081
13cranial nerve structural organization (GO:0021604)4.02301003
14amino acid import (GO:0043090)3.96851190
15locomotory exploration behavior (GO:0035641)3.88961710
16synaptic vesicle maturation (GO:0016188)3.81395301
17behavioral response to nicotine (GO:0035095)3.80677008
18potassium ion import (GO:0010107)3.75530722
19cranial nerve morphogenesis (GO:0021602)3.72292348
20gamma-aminobutyric acid transport (GO:0015812)3.68397029
21righting reflex (GO:0060013)3.63618414
22neuron cell-cell adhesion (GO:0007158)3.61588104
23regulation of synapse structural plasticity (GO:0051823)3.55968612
24synaptic vesicle exocytosis (GO:0016079)3.54203314
25glutamate secretion (GO:0014047)3.53455962
26* neuron-neuron synaptic transmission (GO:0007270)3.50209817
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.47176829
28regulation of synaptic vesicle transport (GO:1902803)3.45720165
29regulation of synaptic vesicle exocytosis (GO:2000300)3.45048302
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43978092
31neuron recognition (GO:0008038)3.43729114
32axonal fasciculation (GO:0007413)3.39105171
33protein localization to synapse (GO:0035418)3.37906344
34neurotransmitter secretion (GO:0007269)3.34167451
35regulation of neuronal synaptic plasticity (GO:0048168)3.24469441
36omega-hydroxylase P450 pathway (GO:0097267)3.24171649
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21661510
38regulation of pigment cell differentiation (GO:0050932)3.19628881
39cochlea development (GO:0090102)3.19419405
40membrane depolarization during action potential (GO:0086010)3.18025338
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17168643
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16031202
43dermatan sulfate biosynthetic process (GO:0030208)3.12474219
44cellular sodium ion homeostasis (GO:0006883)3.10873389
45prepulse inhibition (GO:0060134)3.09962284
46layer formation in cerebral cortex (GO:0021819)3.08667596
47vocalization behavior (GO:0071625)3.07953582
48protein localization to cilium (GO:0061512)3.07559672
49potassium ion homeostasis (GO:0055075)3.05489680
50photoreceptor cell differentiation (GO:0046530)3.04749111
51eye photoreceptor cell differentiation (GO:0001754)3.04749111
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04536764
53lymphoid progenitor cell differentiation (GO:0002320)3.03759772
54positive regulation of synapse maturation (GO:0090129)3.03636762
55cell differentiation in hindbrain (GO:0021533)3.03125520
56regulation of synaptic transmission, glutamatergic (GO:0051966)2.99948440
57innervation (GO:0060384)2.98007991
58nonmotile primary cilium assembly (GO:0035058)2.93574389
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93345434
60positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92490130
61membrane depolarization (GO:0051899)2.92328678
62establishment of nucleus localization (GO:0040023)2.91788117
63regulation of timing of cell differentiation (GO:0048505)2.91038050
64neuromuscular process controlling balance (GO:0050885)2.88501700
65neurotransmitter transport (GO:0006836)2.87453057
66neurotransmitter uptake (GO:0001504)2.87063054
67long-term synaptic potentiation (GO:0060291)2.85345596
68spinal cord development (GO:0021510)2.85236513
69behavioral response to cocaine (GO:0048148)2.85125953
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83821605
71central nervous system projection neuron axonogenesis (GO:0021952)2.82405335
72* ionotropic glutamate receptor signaling pathway (GO:0035235)2.82309176
73sympathetic nervous system development (GO:0048485)2.81919920
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.80689500
75substrate-independent telencephalic tangential migration (GO:0021826)2.80689500
76synaptic vesicle endocytosis (GO:0048488)2.80165887
77regulation of glutamate receptor signaling pathway (GO:1900449)2.79924782
78dermatan sulfate metabolic process (GO:0030205)2.78812122
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78519682
80synapse assembly (GO:0007416)2.78210051
81retinal cone cell development (GO:0046549)2.78140890
82regulation of neurotransmitter transport (GO:0051588)2.77759865
83mesenchymal cell differentiation involved in renal system development (GO:2001012)2.76912439
84mesenchymal cell differentiation involved in kidney development (GO:0072161)2.76912439
85cerebellar Purkinje cell layer development (GO:0021680)2.76617629
86mesonephros development (GO:0001823)2.76447867
87central nervous system neuron axonogenesis (GO:0021955)2.76399525
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75781734
89positive regulation of dendritic spine development (GO:0060999)2.75568775
90regulation of neurotransmitter secretion (GO:0046928)2.75458131
91pyrimidine nucleobase catabolic process (GO:0006208)2.75191054
92axon ensheathment in central nervous system (GO:0032291)2.74868745
93central nervous system myelination (GO:0022010)2.74868745
94positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.74778984
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.72809733
96synapse organization (GO:0050808)2.70901500
97startle response (GO:0001964)2.70423569
98regulation of inositol phosphate biosynthetic process (GO:0010919)2.69543885
99respiratory chain complex IV assembly (GO:0008535)2.63488340
100positive regulation of membrane potential (GO:0045838)2.60794926
101cytochrome complex assembly (GO:0017004)2.60332969
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60117822
103positive regulation of synapse assembly (GO:0051965)2.58958599
104neurotransmitter-gated ion channel clustering (GO:0072578)2.58905790
105regulation of development, heterochronic (GO:0040034)2.57860856
106cerebral cortex radially oriented cell migration (GO:0021799)2.56626522
107auditory behavior (GO:0031223)2.56392831
108protein heterotetramerization (GO:0051290)2.56225128
109amino sugar catabolic process (GO:0046348)2.55594583
110mannosylation (GO:0097502)2.54775212
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52791415
112* glutamate receptor signaling pathway (GO:0007215)2.49739794
113regulation of synapse assembly (GO:0051963)2.45599578
114neuronal action potential (GO:0019228)2.45187941
115short-term memory (GO:0007614)2.44637572
116regulation of respiratory system process (GO:0044065)2.42968098
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42578484
118negative regulation of leukocyte chemotaxis (GO:0002689)2.39413539
119L-amino acid import (GO:0043092)2.38512191
120long-term memory (GO:0007616)2.37558706
121negative regulation of heart rate (GO:0010459)2.35271727
122mechanosensory behavior (GO:0007638)2.35238763
123positive regulation of neurotransmitter secretion (GO:0001956)2.34091095
124* synaptic transmission, glutamatergic (GO:0035249)2.33534930
125serotonin receptor signaling pathway (GO:0007210)2.33495973
126mature B cell differentiation (GO:0002335)2.32208009
127daunorubicin metabolic process (GO:0044597)2.31422188
128polyketide metabolic process (GO:0030638)2.31422188
129doxorubicin metabolic process (GO:0044598)2.31422188
130reflex (GO:0060004)2.30299663
131melanin metabolic process (GO:0006582)2.29918751
132response to auditory stimulus (GO:0010996)2.29149450
133regulation of respiratory gaseous exchange (GO:0043576)2.28099683
134generation of neurons (GO:0048699)2.28025161
135superoxide anion generation (GO:0042554)2.27703484
136cAMP catabolic process (GO:0006198)2.27315857
137limb bud formation (GO:0060174)2.26919003
138dendritic spine morphogenesis (GO:0060997)2.22739336
139regulation of postsynaptic membrane potential (GO:0060078)2.22548495
140thyroid gland development (GO:0030878)2.21703850
141androgen biosynthetic process (GO:0006702)2.21287282
142regulation of synaptic transmission, GABAergic (GO:0032228)2.21273279
143gamma-aminobutyric acid signaling pathway (GO:0007214)2.20822592
144negative regulation of execution phase of apoptosis (GO:1900118)2.18253170
145G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.17911064
146response to folic acid (GO:0051593)2.17909456
147DNA ligation (GO:0006266)2.17243832
148cyclic nucleotide catabolic process (GO:0009214)2.17017809
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.16448759
150negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.16041867
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.15880614
152membrane assembly (GO:0071709)2.15666628
153transmission of nerve impulse (GO:0019226)2.15006059
154developmental pigmentation (GO:0048066)2.14571470
155mast cell activation (GO:0045576)2.13469766
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.13325622
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.13288532
158purinergic nucleotide receptor signaling pathway (GO:0035590)2.11315301
159anatomical structure arrangement (GO:0048532)2.10822547
160oligodendrocyte differentiation (GO:0048709)2.10140071
161regulation of platelet aggregation (GO:0090330)2.09832804
162adult walking behavior (GO:0007628)2.08827744
163response to peptidoglycan (GO:0032494)2.08798932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human4.43816028
2GBX2_23144817_ChIP-Seq_PC3_Human3.90493437
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25613279
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21692036
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.74413133
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69432657
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.62545168
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61186179
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58258502
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54401753
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52096592
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52096592
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44946817
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42335629
15* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37078757
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34792322
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31081503
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.26509080
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14347500
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.13443315
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12093672
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08899695
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08025192
24TAF15_26573619_Chip-Seq_HEK293_Human2.04388713
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.00862508
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96241174
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93316691
28IGF1R_20145208_ChIP-Seq_DFB_Human1.92388703
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92133419
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87992589
31RNF2_27304074_Chip-Seq_NSC_Mouse1.87016638
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84950987
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81291504
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.80727031
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80340508
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75322531
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.74284076
38P300_19829295_ChIP-Seq_ESCs_Human1.69891530
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.68558900
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.65966790
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.63613817
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62589996
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60840663
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59176169
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57866271
46* REST_21632747_ChIP-Seq_MESCs_Mouse1.54817404
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52320563
48AR_21572438_ChIP-Seq_LNCaP_Human1.50587071
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49643745
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49148904
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47611313
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45414188
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44231583
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.41700824
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41611854
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.40654039
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39901419
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.39764374
59VDR_22108803_ChIP-Seq_LS180_Human1.39635662
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38733589
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.37017913
62P53_22387025_ChIP-Seq_ESCs_Mouse1.36280448
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34700397
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32322296
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31730659
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.30957857
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29656604
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.28759841
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25289819
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25018625
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.24740736
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.24167810
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.23786342
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22705619
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22492864
76P300_18555785_Chip-Seq_ESCs_Mouse1.21549317
77* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21091507
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20061919
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20038550
80ER_23166858_ChIP-Seq_MCF-7_Human1.19342122
81* AR_19668381_ChIP-Seq_PC3_Human1.17962502
82TP53_16413492_ChIP-PET_HCT116_Human1.16118643
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.15612260
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.15027497
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14570824
86FUS_26573619_Chip-Seq_HEK293_Human1.14466153
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.14219680
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14061476
89DROSHA_22980978_ChIP-Seq_HELA_Human1.13730073
90* AR_25329375_ChIP-Seq_VCAP_Human1.13654620
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13340762
92* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12981942
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.12885252
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12605208
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11475948
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11275564
97PU1_27457419_Chip-Seq_LIVER_Mouse1.09751934
98* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07383233
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07120490
100TCF4_23295773_ChIP-Seq_U87_Human1.06426463
101* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06393979
102RUNX2_22187159_ChIP-Seq_PCA_Human1.06378570
103KDM2B_26808549_Chip-Seq_REH_Human1.06189451
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05813740
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.04904510
106CTCF_18555785_Chip-Seq_ESCs_Mouse1.03864546
107TP53_18474530_ChIP-ChIP_U2OS_Human1.03784678
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02918996
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02908978
110STAT3_23295773_ChIP-Seq_U87_Human1.02576561
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01875053
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.01812320
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01642076
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.01236132
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00870576
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.00357131
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99877031
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.99557095
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99470235
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.99138057
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98307388
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98236665
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98236665
124IRF1_19129219_ChIP-ChIP_H3396_Human0.98041359
125* EP300_21415370_ChIP-Seq_HL-1_Mouse0.97659032
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97211461
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.97083890
128SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96349655
129* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95472472
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.94693550
131* REST_18959480_ChIP-ChIP_MESCs_Mouse0.94044597
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91705134
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91268586
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89957056
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.87100906
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86094125
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.85173812
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.83593444
139JUN_21703547_ChIP-Seq_K562_Human0.82676294
140KDM2B_26808549_Chip-Seq_K562_Human0.82174362
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81800145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.32954415
2MP0003880_abnormal_central_pattern4.01980626
3MP0001188_hyperpigmentation3.53470406
4MP0005409_darkened_coat_color3.32981373
5MP0006292_abnormal_olfactory_placode3.28952831
6MP0009379_abnormal_foot_pigmentation2.88995798
7MP0004859_abnormal_synaptic_plasticity2.75195710
8MP0001968_abnormal_touch/_nociception2.70988644
9MP0001986_abnormal_taste_sensitivity2.66164139
10MP0004381_abnormal_hair_follicle2.42387869
11MP0002735_abnormal_chemical_nociception2.39609823
12MP0003183_abnormal_peptide_metabolism2.26640109
13MP0005423_abnormal_somatic_nervous2.21644849
14MP0005174_abnormal_tail_pigmentation2.20824602
15MP0004885_abnormal_endolymph2.12678443
16MP0001486_abnormal_startle_reflex2.12429970
17MP0002736_abnormal_nociception_after2.09187501
18MP0009745_abnormal_behavioral_response2.05038489
19MP0002638_abnormal_pupillary_reflex2.02353873
20MP0006276_abnormal_autonomic_nervous1.97635303
21MP0002653_abnormal_ependyma_morphology1.96839446
22MP0000015_abnormal_ear_pigmentation1.95274241
23MP0002876_abnormal_thyroid_physiology1.94210225
24* MP0003635_abnormal_synaptic_transmissio1.92314270
25MP0000372_irregular_coat_pigmentation1.88867195
26MP0002822_catalepsy1.88167129
27MP0000566_synostosis1.86757161
28MP0002102_abnormal_ear_morphology1.78684798
29MP0005171_absent_coat_pigmentation1.76929630
30MP0002734_abnormal_mechanical_nocicepti1.72227027
31* MP0002272_abnormal_nervous_system1.71679555
32MP0004270_analgesia1.68862849
33MP0009046_muscle_twitch1.62581288
34MP0008260_abnormal_autophagy1.60171557
35MP0002572_abnormal_emotion/affect_behav1.58852381
36MP0001984_abnormal_olfaction1.57934677
37* MP0002064_seizures1.54586627
38* MP0002067_abnormal_sensory_capabilities1.53524819
39MP0001970_abnormal_pain_threshold1.53104056
40MP0003283_abnormal_digestive_organ1.52507774
41MP0004742_abnormal_vestibular_system1.51405561
42MP0003787_abnormal_imprinting1.50198903
43MP0005646_abnormal_pituitary_gland1.49080677
44MP0003690_abnormal_glial_cell1.47071377
45MP0003724_increased_susceptibility_to1.46791544
46MP0002063_abnormal_learning/memory/cond1.44842923
47MP0005645_abnormal_hypothalamus_physiol1.43120837
48MP0002184_abnormal_innervation1.41350942
49MP0003329_amyloid_beta_deposits1.41176617
50MP0002277_abnormal_respiratory_mucosa1.40990334
51MP0004142_abnormal_muscle_tone1.40387532
52MP0002557_abnormal_social/conspecific_i1.39116058
53MP0009780_abnormal_chondrocyte_physiolo1.37299301
54MP0002733_abnormal_thermal_nociception1.36976940
55MP0005075_abnormal_melanosome_morpholog1.33030736
56MP0003879_abnormal_hair_cell1.32904298
57MP0008569_lethality_at_weaning1.26504984
58MP0001905_abnormal_dopamine_level1.26448198
59MP0002152_abnormal_brain_morphology1.26331471
60MP0000778_abnormal_nervous_system1.25769505
61MP0000681_abnormal_thyroid_gland1.25729810
62MP0002148_abnormal_hypersensitivity_rea1.25008944
63MP0005499_abnormal_olfactory_system1.23146847
64MP0005394_taste/olfaction_phenotype1.23146847
65MP0002095_abnormal_skin_pigmentation1.23068676
66MP0003938_abnormal_ear_development1.21682091
67MP0001963_abnormal_hearing_physiology1.21225822
68MP0000026_abnormal_inner_ear1.21105572
69MP0003122_maternal_imprinting1.19718854
70MP0008877_abnormal_DNA_methylation1.19215866
71MP0001501_abnormal_sleep_pattern1.14870065
72MP0003631_nervous_system_phenotype1.14048637
73MP0002751_abnormal_autonomic_nervous1.14022252
74MP0003634_abnormal_glial_cell1.11977433
75MP0002249_abnormal_larynx_morphology1.11574493
76MP0003119_abnormal_digestive_system1.11450292
77MP0003632_abnormal_nervous_system1.10472411
78MP0000631_abnormal_neuroendocrine_gland1.07943054
79MP0002177_abnormal_outer_ear1.05464874
80MP0001440_abnormal_grooming_behavior1.03607955
81MP0010386_abnormal_urinary_bladder1.03456001
82MP0000049_abnormal_middle_ear1.02972162
83MP0008789_abnormal_olfactory_epithelium1.02608474
84MP0002009_preneoplasia1.00962492
85MP0003315_abnormal_perineum_morphology0.99406727
86MP0001502_abnormal_circadian_rhythm0.96213740
87MP0001485_abnormal_pinna_reflex0.96160577
88MP0002752_abnormal_somatic_nervous0.95086732
89MP0005187_abnormal_penis_morphology0.94771877
90MP0003890_abnormal_embryonic-extraembry0.94408949
91MP0003121_genomic_imprinting0.94070853
92MP0009785_altered_susceptibility_to0.93619799
93MP0006072_abnormal_retinal_apoptosis0.93140490
94MP0002938_white_spotting0.92398751
95MP0001177_atelectasis0.92262398
96MP0003861_abnormal_nervous_system0.91877227
97MP0001664_abnormal_digestion0.90675075
98MP0001835_abnormal_antigen_presentation0.89860173
99MP0001346_abnormal_lacrimal_gland0.89064672
100MP0005671_abnormal_response_to0.88749357
101* MP0002882_abnormal_neuron_morphology0.86287034
102MP0005551_abnormal_eye_electrophysiolog0.84447801
103MP0005253_abnormal_eye_physiology0.81586305
104MP0005167_abnormal_blood-brain_barrier0.80517282
105MP0002234_abnormal_pharynx_morphology0.80400505
106MP0000920_abnormal_myelination0.76287112
107MP0000955_abnormal_spinal_cord0.75424592
108MP0005379_endocrine/exocrine_gland_phen0.75073030
109MP0002928_abnormal_bile_duct0.72946743
110MP0008995_early_reproductive_senescence0.72762399
111MP0002163_abnormal_gland_morphology0.72756259
112MP0004043_abnormal_pH_regulation0.71607786
113MP0000534_abnormal_ureter_morphology0.71283737
114MP0005000_abnormal_immune_tolerance0.70594054
115MP0001348_abnormal_lacrimal_gland0.68018601
116MP0002069_abnormal_eating/drinking_beha0.67652007
117MP0001529_abnormal_vocalization0.66545925
118MP0005084_abnormal_gallbladder_morpholo0.65216991
119MP0004133_heterotaxia0.65088340
120* MP0002066_abnormal_motor_capabilities/c0.64925172
121MP0004924_abnormal_behavior0.64188687
122MP0005386_behavior/neurological_phenoty0.64188687
123MP0004145_abnormal_muscle_electrophysio0.63781222
124MP0002229_neurodegeneration0.62012276
125MP0001919_abnormal_reproductive_system0.61207281
126MP0002419_abnormal_innate_immunity0.60531413
127MP0004510_myositis0.60086592
128MP0003137_abnormal_impulse_conducting0.59929989
129MP0000579_abnormal_nail_morphology0.58886477
130MP0005025_abnormal_response_to0.58109865
131MP0009250_abnormal_appendicular_skeleto0.57748563
132MP0004811_abnormal_neuron_physiology0.57025693
133MP0004147_increased_porphyrin_level0.56760749
134MP0005195_abnormal_posterior_eye0.56666407
135MP0002909_abnormal_adrenal_gland0.56622904
136MP0002160_abnormal_reproductive_system0.56537634
137MP0003941_abnormal_skin_development0.54366809
138MP0003633_abnormal_nervous_system0.53534566

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.97206097
2Atonic seizures (HP:0010819)4.72532421
3Type I transferrin isoform profile (HP:0003642)3.89647725
4Nonprogressive disorder (HP:0003680)3.80548449
5Abnormality of the axillary hair (HP:0100134)3.49752342
6Abnormality of secondary sexual hair (HP:0009888)3.49752342
7Absence seizures (HP:0002121)3.46550851
8Febrile seizures (HP:0002373)3.45543043
9Neurofibrillary tangles (HP:0002185)3.33453157
10Reduced antithrombin III activity (HP:0001976)3.27473171
11Oligodactyly (hands) (HP:0001180)3.27073171
12Dialeptic seizures (HP:0011146)3.20809710
13Hypothermia (HP:0002045)3.19811374
14Myokymia (HP:0002411)3.17175286
15Hemiparesis (HP:0001269)3.08942654
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.06759170
17Absent/shortened dynein arms (HP:0200106)3.06759170
18Supranuclear gaze palsy (HP:0000605)3.05512451
19Abnormality of binocular vision (HP:0011514)3.03443346
20Diplopia (HP:0000651)3.03443346
21Hemiplegia (HP:0002301)2.94607071
22Thyroid-stimulating hormone excess (HP:0002925)2.90574848
23Generalized tonic-clonic seizures (HP:0002069)2.89166375
24Dysdiadochokinesis (HP:0002075)2.80267836
25Abnormal ciliary motility (HP:0012262)2.80220552
263-Methylglutaconic aciduria (HP:0003535)2.77386726
27Parakeratosis (HP:0001036)2.74226476
28Oligodactyly (HP:0012165)2.72770607
29True hermaphroditism (HP:0010459)2.71914732
30Patchy hypopigmentation of hair (HP:0011365)2.68229654
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65974012
32Gait imbalance (HP:0002141)2.58453818
33Abnormality of the diencephalon (HP:0010662)2.58126966
34Abnormal respiratory motile cilium morphology (HP:0005938)2.56201910
35Abnormal respiratory epithelium morphology (HP:0012253)2.56201910
36Abnormal sex determination (HP:0012244)2.54903999
37Sex reversal (HP:0012245)2.54903999
38Hyperventilation (HP:0002883)2.54112803
39Truncal ataxia (HP:0002078)2.52424873
40Abnormal eating behavior (HP:0100738)2.50589575
41Gaze-evoked nystagmus (HP:0000640)2.49000256
42Torticollis (HP:0000473)2.48357746
43White forelock (HP:0002211)2.47898028
44Megalencephaly (HP:0001355)2.47531336
45Progressive cerebellar ataxia (HP:0002073)2.47122680
46Bundle branch block (HP:0011710)2.47074200
47Dry hair (HP:0011359)2.46885677
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.46576170
49Vitreoretinal degeneration (HP:0000655)2.43879253
50Bronchomalacia (HP:0002780)2.41221808
51Postural instability (HP:0002172)2.38965984
52Peripheral hypomyelination (HP:0007182)2.38444650
53Type II lissencephaly (HP:0007260)2.33847382
54Abnormal protein glycosylation (HP:0012346)2.32261600
55Abnormal glycosylation (HP:0012345)2.32261600
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32261600
57Abnormal protein N-linked glycosylation (HP:0012347)2.32261600
58Spastic gait (HP:0002064)2.31451727
59Anterior segment dysgenesis (HP:0007700)2.30845068
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30687984
61Abnormality of magnesium homeostasis (HP:0004921)2.30542718
62Morphological abnormality of the inner ear (HP:0011390)2.29728391
63Abnormal respiratory motile cilium physiology (HP:0012261)2.29487231
64Optic nerve hypoplasia (HP:0000609)2.28135011
65Rib fusion (HP:0000902)2.27202990
66Polyphagia (HP:0002591)2.25248075
67Maternal diabetes (HP:0009800)2.23766722
68Attenuation of retinal blood vessels (HP:0007843)2.22622463
69Genital tract atresia (HP:0001827)2.21217904
70Absent septum pellucidum (HP:0001331)2.21007850
71Cerebral inclusion bodies (HP:0100314)2.20678078
72Intention tremor (HP:0002080)2.20621612
73Vaginal atresia (HP:0000148)2.19503724
74Abnormality of the labia minora (HP:0012880)2.19054329
75Decreased central vision (HP:0007663)2.18392454
76Ulnar claw (HP:0001178)2.17671385
77Short tibia (HP:0005736)2.17347968
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16951434
79Urinary bladder sphincter dysfunction (HP:0002839)2.16864531
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.16252088
81Septo-optic dysplasia (HP:0100842)2.16190070
82Severe visual impairment (HP:0001141)2.16181985
83Ankle clonus (HP:0011448)2.15918209
84Renal Fanconi syndrome (HP:0001994)2.15572619
85Impaired vibration sensation in the lower limbs (HP:0002166)2.12177691
86Retinal dysplasia (HP:0007973)2.12014292
87Retrobulbar optic neuritis (HP:0100654)2.11828005
88Optic neuritis (HP:0100653)2.11828005
89Sleep apnea (HP:0010535)2.11729500
90Supernumerary spleens (HP:0009799)2.09976986
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08951074
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.08951074
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08887886
94Esophageal atresia (HP:0002032)2.08824532
95Esotropia (HP:0000565)2.07303427
96Anophthalmia (HP:0000528)2.07280646
97Chronic obstructive pulmonary disease (HP:0006510)2.06167412
98Obstructive lung disease (HP:0006536)2.06167412
99Status epilepticus (HP:0002133)2.05487748
100Stomatitis (HP:0010280)2.04584412
101Focal dystonia (HP:0004373)2.04271136
102Focal seizures (HP:0007359)2.04200825
103Type 2 muscle fiber atrophy (HP:0003554)2.03495920
104Increased circulating renin level (HP:0000848)2.03447218
105Conical tooth (HP:0000698)2.00221748
106Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00108012
107Congenital primary aphakia (HP:0007707)1.99737960
108Abnormality of the septum pellucidum (HP:0007375)1.98977679
109Aplasia involving bones of the upper limbs (HP:0009823)1.98676852
110Aplasia of the phalanges of the hand (HP:0009802)1.98676852
111Aplasia involving bones of the extremities (HP:0009825)1.98676852
112Hypomagnesemia (HP:0002917)1.98316920
113Broad-based gait (HP:0002136)1.98131073
114Epileptiform EEG discharges (HP:0011182)1.97481201
115Optic disc pallor (HP:0000543)1.96027144
116Dysmetria (HP:0001310)1.95672938
117Protruding tongue (HP:0010808)1.94793483
118Specific learning disability (HP:0001328)1.94353639
119Hypoplasia of the fovea (HP:0007750)1.94205162
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.94205162
121Epileptic encephalopathy (HP:0200134)1.94099280
122Abnormality of the corticospinal tract (HP:0002492)1.93671949
123Pheochromocytoma (HP:0002666)1.91596328
124Impaired smooth pursuit (HP:0007772)1.91116062
125Pancreatic fibrosis (HP:0100732)1.90618234
126Split foot (HP:0001839)1.88555011
127Bradycardia (HP:0001662)1.88396140
128Humeroradial synostosis (HP:0003041)1.87896488
129Synostosis involving the elbow (HP:0003938)1.87896488
130Increased hepatocellular lipid droplets (HP:0006565)1.87393461
131Abnormal rod and cone electroretinograms (HP:0008323)1.87306520
132Amblyopia (HP:0000646)1.86785586
133Lissencephaly (HP:0001339)1.85743154
134Meningitis (HP:0001287)1.85122792
135Median cleft lip (HP:0000161)1.84344130
136Turricephaly (HP:0000262)1.83276813
137Amelogenesis imperfecta (HP:0000705)1.82945157
138Abnormality of cochlea (HP:0000375)1.80672058
139Keratoconus (HP:0000563)1.80063183
140Increased corneal curvature (HP:0100692)1.80063183
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79955456
142Agitation (HP:0000713)1.79441183
143Mediastinal lymphadenopathy (HP:0100721)1.78150090
144Scanning speech (HP:0002168)1.77948144
145Large eyes (HP:0001090)1.76781885
146Abnormality of midbrain morphology (HP:0002418)1.76521834
147Molar tooth sign on MRI (HP:0002419)1.76521834
148Medial flaring of the eyebrow (HP:0010747)1.74285218
149Action tremor (HP:0002345)1.74153220
150Abnormality of renal resorption (HP:0011038)1.73655347
151Abnormality of dental color (HP:0011073)1.73627073
152Nephrogenic diabetes insipidus (HP:0009806)1.73163100
153Anencephaly (HP:0002323)1.72970435
154Abnormality of incisor morphology (HP:0011063)1.72737629
155EEG with generalized epileptiform discharges (HP:0011198)1.72359558
156Ventricular fibrillation (HP:0001663)1.72089897
157Male pseudohermaphroditism (HP:0000037)1.69452725
158Craniofacial dystonia (HP:0012179)1.68164192
159Preaxial hand polydactyly (HP:0001177)1.67325502
160Poor coordination (HP:0002370)1.67171646
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66685456
162Morphological abnormality of the pyramidal tract (HP:0002062)1.66638219
163Progressive inability to walk (HP:0002505)1.66610383
164Neuroendocrine neoplasm (HP:0100634)1.66352549
165Limb dystonia (HP:0002451)1.66339596
166Anomalous pulmonary venous return (HP:0010772)1.65823404
167Hypoplasia of the brainstem (HP:0002365)1.65735061
168Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65735061
169Anxiety (HP:0000739)1.65684771
170Abnormality of the fovea (HP:0000493)1.65416383
171Muscle fiber atrophy (HP:0100295)1.64944888
172Heart block (HP:0012722)1.63565101
173Chromsome breakage (HP:0040012)1.63499946
174Congenital sensorineural hearing impairment (HP:0008527)1.63091340
175Inability to walk (HP:0002540)1.63077581
176Clubbing of toes (HP:0100760)1.62946137
177Agammaglobulinemia (HP:0004432)1.62850470
178Nephronophthisis (HP:0000090)1.62611686
179Fair hair (HP:0002286)1.62068504
180Obstructive sleep apnea (HP:0002870)1.61816851
181Pancreatic cysts (HP:0001737)1.61385321
182Abnormality of calcium-phosphate metabolism (HP:0100530)1.61265312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.80121851
2TNIK4.74349643
3MUSK4.05755384
4PNCK3.62730413
5MKNK23.22032772
6PRKD32.63143286
7TYRO32.55955588
8MAPK152.55929740
9MAP2K72.50994811
10PAK62.30155739
11NTRK32.23587022
12MAP3K122.16095480
13WNK32.15405179
14MAPK132.09052184
15STK162.04102383
16MKNK11.93743379
17PRPF4B1.92738548
18MAP3K91.84452632
19FES1.78601203
20NME21.78425733
21TXK1.77676306
22RIPK41.67675619
23NLK1.66655674
24ADRBK21.62606935
25CAMKK11.57835854
26IRAK41.54671763
27CDK191.52390157
28EPHA41.47564382
29NTRK11.46217538
30IRAK31.42843944
31MAP2K41.39438815
32YES11.38245855
33EIF2AK31.29583084
34TEC1.28135963
35BMPR21.27521815
36TAOK31.23771344
37TLK11.23285249
38GRK71.21071806
39BMPR1B1.20033621
40PLK41.20013136
41EIF2AK21.18939918
42CSNK1G21.16325257
43IRAK21.16122436
44CAMK11.14708202
45LATS21.10681934
46NEK61.05963189
47GRK51.05432595
48TSSK61.05063361
49PRKD21.04625887
50SRPK11.04583122
51PINK11.03761360
52MAP3K141.03340715
53TNK21.02981674
54CDK31.01234722
55CLK10.98178280
56NTRK20.97577199
57EPHB20.97553283
58GRK10.96033076
59SIK30.95724209
60IRAK10.91885868
61MAPKAPK50.89881941
62ARAF0.89054618
63CAMKK20.88945827
64PHKG20.88893232
65PHKG10.88893232
66KSR10.87953215
67CAMK1D0.85880769
68MARK10.84877842
69TIE10.83667472
70BLK0.82633705
71FGFR20.81553908
72PRKCZ0.79742633
73PLK20.77895759
74KIT0.77140795
75SGK20.74821566
76CSNK1D0.74741418
77EPHA30.74467065
78CAMK2B0.72241955
79CAMK2A0.70323697
80PRKCH0.70135194
81CSNK1G10.68399870
82DYRK1A0.67456431
83WEE10.67092652
84MAPK100.66815435
85SGK4940.66256195
86SGK2230.66256195
87CAMK1G0.65855624
88WNK40.65172172
89MAPK70.64716562
90RET0.64316379
91PRKG20.63718904
92UHMK10.63557348
93WNK10.59944915
94OXSR10.59734732
95MAPK120.59229825
96PRKCE0.59191840
97STK110.58228628
98PKN10.57972676
99VRK10.57665895
100SYK0.57651747
101IKBKB0.57645934
102ROCK20.56038223
103MATK0.55329392
104SGK10.55310320
105LYN0.54681519
106BTK0.53423562
107CDK80.52543386
108CDK50.51844259
109CSNK1A1L0.50959958
110MAP2K60.50628117
111INSRR0.50205692
112MINK10.49996231
113DYRK20.49957484
114SIK20.49924003
115CDK150.49883888
116PRKCG0.49439314
117IKBKE0.48155382
118CDK180.47730646
119STK38L0.46786948
120RPS6KA30.45367331
121CDK140.44604407
122MAP3K130.44367534
123CAMK2D0.43616974
124CDK11A0.43590076
125NME10.42549961
126PRKG10.42500077
127PIM20.42260268
128MAPK40.41195871
129ZAK0.40532077
130STK380.40475409
131PRKACA0.40384267
132MARK20.40127566
133LRRK20.39787687
134KSR20.39390833
135ROCK10.38483622
136HIPK20.36689365
137HCK0.36683647
138CAMK2G0.34595760
139TAOK20.34564501
140STK390.33592646
141MAP3K10.32522100
142CSNK1G30.32144730
143MAP3K40.32114321
144PDGFRB0.31658911
145DAPK20.30344887
146LIMK10.29995946
147PRKDC0.29626627
148ERBB20.29454667
149AKT20.29060282
150ADRBK10.28007690
151CAMK40.25740172

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13976757
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76766078
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32534521
4Olfactory transduction_Homo sapiens_hsa047402.27536635
5* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04910323
6Morphine addiction_Homo sapiens_hsa050321.97103251
7Taste transduction_Homo sapiens_hsa047421.94270418
8Phototransduction_Homo sapiens_hsa047441.85284813
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84123412
10* Glutamatergic synapse_Homo sapiens_hsa047241.81021663
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77418335
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77409188
13Nitrogen metabolism_Homo sapiens_hsa009101.68635094
14Circadian entrainment_Homo sapiens_hsa047131.67118812
15Ribosome_Homo sapiens_hsa030101.66096362
16Serotonergic synapse_Homo sapiens_hsa047261.65976061
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55481714
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54340767
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53979944
20GABAergic synapse_Homo sapiens_hsa047271.53584851
21Sphingolipid metabolism_Homo sapiens_hsa006001.50215506
22Graft-versus-host disease_Homo sapiens_hsa053321.48072212
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48040737
24Salivary secretion_Homo sapiens_hsa049701.47122056
25Allograft rejection_Homo sapiens_hsa053301.45990258
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41208111
27Estrogen signaling pathway_Homo sapiens_hsa049151.40974114
28Calcium signaling pathway_Homo sapiens_hsa040201.40874248
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38181196
30Long-term depression_Homo sapiens_hsa047301.36571755
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33086337
32Autoimmune thyroid disease_Homo sapiens_hsa053201.28835147
33Arachidonic acid metabolism_Homo sapiens_hsa005901.24954777
34Synaptic vesicle cycle_Homo sapiens_hsa047211.22761131
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22685902
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20578870
37Oxidative phosphorylation_Homo sapiens_hsa001901.19115715
38Asthma_Homo sapiens_hsa053101.18059812
39Cholinergic synapse_Homo sapiens_hsa047251.17218765
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13684590
41Rheumatoid arthritis_Homo sapiens_hsa053231.09509077
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09011227
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08147911
44African trypanosomiasis_Homo sapiens_hsa051431.07897846
45Ether lipid metabolism_Homo sapiens_hsa005651.07359954
46Thyroid hormone synthesis_Homo sapiens_hsa049181.07290752
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04089497
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01502618
49Protein export_Homo sapiens_hsa030601.01027025
50Type I diabetes mellitus_Homo sapiens_hsa049401.00529137
51Insulin secretion_Homo sapiens_hsa049111.00526321
52Bile secretion_Homo sapiens_hsa049760.97528224
53Fanconi anemia pathway_Homo sapiens_hsa034600.97350216
54Amphetamine addiction_Homo sapiens_hsa050310.97271276
55Other glycan degradation_Homo sapiens_hsa005110.97146322
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95783092
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95279514
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94918436
59Hematopoietic cell lineage_Homo sapiens_hsa046400.93393592
60Hippo signaling pathway_Homo sapiens_hsa043900.92759212
61Long-term potentiation_Homo sapiens_hsa047200.92140646
62Axon guidance_Homo sapiens_hsa043600.91601087
63cAMP signaling pathway_Homo sapiens_hsa040240.87286443
64Alzheimers disease_Homo sapiens_hsa050100.86921073
65Ovarian steroidogenesis_Homo sapiens_hsa049130.83740296
66Dopaminergic synapse_Homo sapiens_hsa047280.83560897
67Gastric acid secretion_Homo sapiens_hsa049710.83054950
68Oocyte meiosis_Homo sapiens_hsa041140.82755000
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82313316
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.79984157
71Renin secretion_Homo sapiens_hsa049240.79841417
72Basal cell carcinoma_Homo sapiens_hsa052170.79182155
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.76420093
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76197615
75Notch signaling pathway_Homo sapiens_hsa043300.75492109
76Rap1 signaling pathway_Homo sapiens_hsa040150.75439028
77ErbB signaling pathway_Homo sapiens_hsa040120.74846298
78Dorso-ventral axis formation_Homo sapiens_hsa043200.74375893
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74097181
80Parkinsons disease_Homo sapiens_hsa050120.73956484
81Primary immunodeficiency_Homo sapiens_hsa053400.73670131
82Melanogenesis_Homo sapiens_hsa049160.73009319
83Cocaine addiction_Homo sapiens_hsa050300.72312357
84MAPK signaling pathway_Homo sapiens_hsa040100.71062294
85Collecting duct acid secretion_Homo sapiens_hsa049660.70944779
86GnRH signaling pathway_Homo sapiens_hsa049120.70387584
87Malaria_Homo sapiens_hsa051440.70008502
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69840240
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68711547
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68504596
91Oxytocin signaling pathway_Homo sapiens_hsa049210.67895142
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67167142
93Homologous recombination_Homo sapiens_hsa034400.65228449
94Hedgehog signaling pathway_Homo sapiens_hsa043400.64840932
95Glioma_Homo sapiens_hsa052140.64733429
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63818877
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.63675702
98Leishmaniasis_Homo sapiens_hsa051400.62822742
99Wnt signaling pathway_Homo sapiens_hsa043100.61475463
100Prion diseases_Homo sapiens_hsa050200.61448204
101Cardiac muscle contraction_Homo sapiens_hsa042600.60511003
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60438240
103Basal transcription factors_Homo sapiens_hsa030220.60331709
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59621438
105Purine metabolism_Homo sapiens_hsa002300.59429293
106Type II diabetes mellitus_Homo sapiens_hsa049300.59263932
107Huntingtons disease_Homo sapiens_hsa050160.58772331
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58305099
109Choline metabolism in cancer_Homo sapiens_hsa052310.58230154
110Pancreatic secretion_Homo sapiens_hsa049720.56255459
111Measles_Homo sapiens_hsa051620.55618578
112Circadian rhythm_Homo sapiens_hsa047100.55523710
113Ras signaling pathway_Homo sapiens_hsa040140.55512670
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.55277767
115Tight junction_Homo sapiens_hsa045300.54901807
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52868271
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51914784
118Chemokine signaling pathway_Homo sapiens_hsa040620.51314306
119Fatty acid biosynthesis_Homo sapiens_hsa000610.50647956
120Linoleic acid metabolism_Homo sapiens_hsa005910.48822973
121Salmonella infection_Homo sapiens_hsa051320.48589608
122Pertussis_Homo sapiens_hsa051330.48219489
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.48061080
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47006911
125Gap junction_Homo sapiens_hsa045400.46550912
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46434930
127ABC transporters_Homo sapiens_hsa020100.46253040
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45954870
129Tuberculosis_Homo sapiens_hsa051520.45913536
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45766591
131Alcoholism_Homo sapiens_hsa050340.45081760
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45051527
133Regulation of autophagy_Homo sapiens_hsa041400.44982037
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.44918691
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44247621
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43637672
137Histidine metabolism_Homo sapiens_hsa003400.40218746
138Colorectal cancer_Homo sapiens_hsa052100.40077844
139beta-Alanine metabolism_Homo sapiens_hsa004100.38770988
140VEGF signaling pathway_Homo sapiens_hsa043700.35521686
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.34615642
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.33975519
143Dilated cardiomyopathy_Homo sapiens_hsa054140.31975308
144Glycerolipid metabolism_Homo sapiens_hsa005610.31503573
145Inositol phosphate metabolism_Homo sapiens_hsa005620.31482846
146Endometrial cancer_Homo sapiens_hsa052130.29120096
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27494729
148Endocytosis_Homo sapiens_hsa041440.26434113

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