GRIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.78523873
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.75544743
3locomotory exploration behavior (GO:0035641)6.44428246
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.82605704
5* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78202097
6vocalization behavior (GO:0071625)5.69056848
7synaptic vesicle exocytosis (GO:0016079)5.51495620
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.48807824
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.40757841
10glutamate secretion (GO:0014047)5.37692793
11regulation of synaptic vesicle exocytosis (GO:2000300)5.22686338
12regulation of glutamate receptor signaling pathway (GO:1900449)5.17188461
13cerebellar granule cell differentiation (GO:0021707)5.13783155
14neuronal action potential propagation (GO:0019227)4.81494569
15exploration behavior (GO:0035640)4.78898118
16neurotransmitter secretion (GO:0007269)4.77777459
17protein localization to synapse (GO:0035418)4.76085510
18* regulation of neuronal synaptic plasticity (GO:0048168)4.72875781
19amino acid import (GO:0043090)4.72108443
20regulation of synapse structural plasticity (GO:0051823)4.70759280
21regulation of synaptic vesicle transport (GO:1902803)4.69825818
22* ionotropic glutamate receptor signaling pathway (GO:0035235)4.64712015
23* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55092711
24layer formation in cerebral cortex (GO:0021819)4.39403689
25gamma-aminobutyric acid transport (GO:0015812)4.38961492
26dendritic spine morphogenesis (GO:0060997)4.34153451
27neurotransmitter-gated ion channel clustering (GO:0072578)4.33009139
28potassium ion homeostasis (GO:0055075)4.31913752
29cellular potassium ion homeostasis (GO:0030007)4.31448414
30* synaptic transmission, glutamatergic (GO:0035249)4.26456886
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.23281588
32negative regulation of dendrite morphogenesis (GO:0050774)4.17187438
33sodium ion export (GO:0071436)4.16712743
34central nervous system myelination (GO:0022010)4.12020076
35axon ensheathment in central nervous system (GO:0032291)4.12020076
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11167505
37neuron cell-cell adhesion (GO:0007158)4.09483244
38* glutamate receptor signaling pathway (GO:0007215)4.09477112
39regulation of synapse maturation (GO:0090128)4.04897414
40proline transport (GO:0015824)3.98870695
41* neuron-neuron synaptic transmission (GO:0007270)3.97757640
42* long-term memory (GO:0007616)3.93155461
43neuromuscular process controlling balance (GO:0050885)3.92135312
44* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.85237370
45positive regulation of synapse maturation (GO:0090129)3.80857262
46regulation of dendritic spine morphogenesis (GO:0061001)3.79901750
47* positive regulation of membrane potential (GO:0045838)3.79295678
48neurotransmitter transport (GO:0006836)3.78241385
49neuromuscular process controlling posture (GO:0050884)3.73285785
50activation of protein kinase A activity (GO:0034199)3.72854082
51glycine transport (GO:0015816)3.72580786
52* regulation of synaptic plasticity (GO:0048167)3.72356933
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70052462
54auditory behavior (GO:0031223)3.66716001
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.66548952
56cerebellar Purkinje cell differentiation (GO:0021702)3.64586812
57* regulation of postsynaptic membrane potential (GO:0060078)3.64550497
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64115308
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.61325327
60transmission of nerve impulse (GO:0019226)3.60103056
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.57994080
62regulation of neurotransmitter secretion (GO:0046928)3.56725836
63regulation of neurotransmitter levels (GO:0001505)3.54323683
64cell communication by electrical coupling (GO:0010644)3.51641846
65response to auditory stimulus (GO:0010996)3.48916987
66synaptic vesicle endocytosis (GO:0048488)3.48325178
67vesicle docking involved in exocytosis (GO:0006904)3.47409519
68acidic amino acid transport (GO:0015800)3.47112802
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.46140172
70neurotransmitter uptake (GO:0001504)3.40652110
71long-term synaptic potentiation (GO:0060291)3.39631848
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38036835
73membrane depolarization during action potential (GO:0086010)3.37255762
74positive regulation of neurotransmitter secretion (GO:0001956)3.37169351
75positive regulation of neurotransmitter transport (GO:0051590)3.36523356
76neuronal ion channel clustering (GO:0045161)3.36222147
77regulation of vesicle fusion (GO:0031338)3.33934394
78regulation of ARF protein signal transduction (GO:0032012)3.32385396
79regulation of neurotransmitter transport (GO:0051588)3.32202200
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29537419
81membrane hyperpolarization (GO:0060081)3.28948238
82L-amino acid import (GO:0043092)3.26506070
83establishment of synaptic vesicle localization (GO:0097480)3.26429062
84synaptic vesicle transport (GO:0048489)3.26429062
85neuromuscular synaptic transmission (GO:0007274)3.26323335
86dendrite morphogenesis (GO:0048813)3.26218211
87neuron recognition (GO:0008038)3.25066076
88dendritic spine organization (GO:0097061)3.24997342
89cell differentiation in hindbrain (GO:0021533)3.24918346
90gamma-aminobutyric acid signaling pathway (GO:0007214)3.24115347
91regulation of exocytosis (GO:0017157)3.21802281
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21258470
93* membrane depolarization (GO:0051899)3.21063201
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19847103
95neuromuscular process (GO:0050905)3.19270466
96vesicle docking (GO:0048278)3.18831479
97positive regulation of dendritic spine development (GO:0060999)3.18262805
98postsynaptic membrane organization (GO:0001941)3.13484349
99regulation of dendritic spine development (GO:0060998)3.13457190
100positive regulation of dendrite development (GO:1900006)3.12400315
101dicarboxylic acid transport (GO:0006835)3.11419030
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10338264
103vesicle transport along microtubule (GO:0047496)3.10145933
104positive regulation of synaptic transmission (GO:0050806)3.09733391
105behavioral fear response (GO:0001662)3.09723768
106behavioral defense response (GO:0002209)3.09723768
107signal release (GO:0023061)3.09364332
108negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08158577
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08076439
110* learning (GO:0007612)3.07891972
111innervation (GO:0060384)3.07266692
112axonal fasciculation (GO:0007413)3.06474171
113* regulation of synaptic transmission (GO:0050804)3.05369797
114positive regulation of dendritic spine morphogenesis (GO:0061003)3.04537629
115potassium ion import (GO:0010107)3.03025362
116* synaptic transmission (GO:0007268)3.00028720
117cellular sodium ion homeostasis (GO:0006883)2.97236949
118adult walking behavior (GO:0007628)2.96658063
119cerebellar Purkinje cell layer development (GO:0021680)2.95144149
120regulation of voltage-gated calcium channel activity (GO:1901385)2.95046100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05519309
2GBX2_23144817_ChIP-Seq_PC3_Human3.14967515
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11778851
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09123905
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08250823
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.01035034
7REST_21632747_ChIP-Seq_MESCs_Mouse2.91038951
8DROSHA_22980978_ChIP-Seq_HELA_Human2.90401644
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79767796
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79767796
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71340607
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61071878
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60347612
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58411297
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48776659
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44538540
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41588603
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.39156599
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.38035491
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35499404
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.33655412
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33548658
23* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31976547
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.23757643
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.20039999
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15106916
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06260246
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91727309
29AR_21572438_ChIP-Seq_LNCaP_Human1.80788721
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.75609461
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67544787
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61245694
33SMAD4_21799915_ChIP-Seq_A2780_Human1.48057917
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47110565
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47008332
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46956873
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37319780
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.35644987
39KDM2B_26808549_Chip-Seq_K562_Human1.35317630
40* LXR_22292898_ChIP-Seq_THP-1_Human1.34693906
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30160405
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.28457033
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.26690428
44AR_19668381_ChIP-Seq_PC3_Human1.26011349
45ZNF274_21170338_ChIP-Seq_K562_Hela1.25582302
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25530788
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25378943
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24627926
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24591619
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23758411
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20103135
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19139950
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18857860
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17829170
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17820986
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16603106
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16180066
58STAT3_23295773_ChIP-Seq_U87_Human1.15099223
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.14996581
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14805105
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13411365
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12591094
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.12531993
64AR_25329375_ChIP-Seq_VCAP_Human1.10997891
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10773113
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09311499
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09114441
68TAF15_26573619_Chip-Seq_HEK293_Human1.08589710
69OCT4_19829295_ChIP-Seq_ESCs_Human1.08470441
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08168437
71SMC4_20622854_ChIP-Seq_HELA_Human1.08076553
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07758871
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.05445953
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03086427
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02404426
76P300_19829295_ChIP-Seq_ESCs_Human1.01050351
77DPY_21335234_ChIP-Seq_ESCs_Mouse1.00268381
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00017568
79TCF4_23295773_ChIP-Seq_U87_Human0.99757160
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98968316
81ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98594367
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97031500
83TET1_21490601_ChIP-Seq_MESCs_Mouse0.96609079
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96127392
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96057353
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.95166047
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94829393
88CTCF_27219007_Chip-Seq_Bcells_Human0.93927565
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93912278
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.93912177
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.93805765
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93796124
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93344455
94AHR_22903824_ChIP-Seq_MCF-7_Human0.92923406
95CREB1_26743006_Chip-Seq_LNCaP_Human0.92871270
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.92860202
97RXR_22108803_ChIP-Seq_LS180_Human0.92831295
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92151625
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91787403
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91675370
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91385279
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91106746
103TP53_16413492_ChIP-PET_HCT116_Human0.89260022
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.88843167
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87726207
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87578191
107P68_20966046_ChIP-Seq_HELA_Human0.87100694
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87073234
109RNF2_27304074_Chip-Seq_NSC_Mouse0.86705165
110* KDM2B_26808549_Chip-Seq_DND41_Human0.86133119
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85728323
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85363899
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.85218881
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85209410
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85107660
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83284342
117EGR1_19032775_ChIP-ChIP_M12_Human0.82244372
118RUNX2_22187159_ChIP-Seq_PCA_Human0.81822670
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.81543134
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80695277
121MYC_19915707_ChIP-ChIP_AK7_Human0.80627918
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80577860
123* KLF4_19829295_ChIP-Seq_ESCs_Human0.80339964
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79189837
125* SMAD4_21741376_ChIP-Seq_ESCs_Human0.78070326
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77929051
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.75212624
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73716768
129* KDM2B_26808549_Chip-Seq_JURKAT_Human0.72086582
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.71966850
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71860174
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70672835
133TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70667823
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.70011023
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.69167664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.09382330
2MP0003880_abnormal_central_pattern4.61937820
3* MP0003635_abnormal_synaptic_transmissio4.43660753
4MP0004270_analgesia3.85801587
5MP0002822_catalepsy3.57584625
6* MP0009745_abnormal_behavioral_response3.57011922
7* MP0002063_abnormal_learning/memory/cond3.48171335
8MP0009046_muscle_twitch3.34576521
9* MP0002064_seizures3.28686876
10MP0005423_abnormal_somatic_nervous3.06829413
11MP0001968_abnormal_touch/_nociception2.95351806
12* MP0002572_abnormal_emotion/affect_behav2.82796168
13MP0002734_abnormal_mechanical_nocicepti2.69936093
14* MP0002272_abnormal_nervous_system2.66126551
15* MP0001486_abnormal_startle_reflex2.55725131
16MP0001501_abnormal_sleep_pattern2.36306115
17MP0008569_lethality_at_weaning2.18808390
18MP0002736_abnormal_nociception_after2.15187694
19MP0002735_abnormal_chemical_nociception2.11167278
20MP0001440_abnormal_grooming_behavior2.04806678
21MP0002733_abnormal_thermal_nociception2.02830633
22MP0009780_abnormal_chondrocyte_physiolo2.01902071
23MP0001970_abnormal_pain_threshold2.00230491
24MP0002909_abnormal_adrenal_gland1.99000530
25MP0004858_abnormal_nervous_system1.90029746
26* MP0002067_abnormal_sensory_capabilities1.86840704
27MP0003329_amyloid_beta_deposits1.86317680
28* MP0004811_abnormal_neuron_physiology1.85384765
29MP0002184_abnormal_innervation1.75053948
30MP0003879_abnormal_hair_cell1.72918502
31MP0005386_behavior/neurological_phenoty1.71528950
32MP0004924_abnormal_behavior1.71528950
33MP0005646_abnormal_pituitary_gland1.71177876
34* MP0002557_abnormal_social/conspecific_i1.69657026
35MP0004885_abnormal_endolymph1.60219663
36MP0000778_abnormal_nervous_system1.58494888
37MP0000955_abnormal_spinal_cord1.58278736
38MP0003123_paternal_imprinting1.52108430
39MP0003787_abnormal_imprinting1.48936262
40MP0001984_abnormal_olfaction1.47254070
41* MP0002066_abnormal_motor_capabilities/c1.45735368
42* MP0002882_abnormal_neuron_morphology1.39595412
43* MP0003633_abnormal_nervous_system1.39364737
44MP0005645_abnormal_hypothalamus_physiol1.30643921
45MP0001502_abnormal_circadian_rhythm1.28290427
46MP0004142_abnormal_muscle_tone1.27130772
47MP0003283_abnormal_digestive_organ1.21233740
48MP0000569_abnormal_digit_pigmentation1.19254411
49MP0003075_altered_response_to1.18318556
50* MP0003631_nervous_system_phenotype1.17838341
51MP0006276_abnormal_autonomic_nervous1.17075071
52MP0001529_abnormal_vocalization1.10695288
53MP0001346_abnormal_lacrimal_gland1.09659211
54MP0008961_abnormal_basal_metabolism1.09489985
55* MP0002152_abnormal_brain_morphology1.07859622
56MP0004145_abnormal_muscle_electrophysio1.03625136
57MP0003690_abnormal_glial_cell1.03538816
58MP0001905_abnormal_dopamine_level1.03343960
59MP0001348_abnormal_lacrimal_gland1.01774694
60MP0003122_maternal_imprinting1.01181348
61MP0004147_increased_porphyrin_level0.99128141
62MP0002229_neurodegeneration0.97843838
63* MP0002069_abnormal_eating/drinking_beha0.95692270
64MP0000920_abnormal_myelination0.91213652
65MP0001188_hyperpigmentation0.90603637
66MP0003632_abnormal_nervous_system0.90145462
67MP0000751_myopathy0.89302848
68MP0005167_abnormal_blood-brain_barrier0.88910355
69MP0000013_abnormal_adipose_tissue0.88413902
70* MP0008874_decreased_physiological_sensi0.87766899
71* MP0008872_abnormal_physiological_respon0.85589831
72MP0005535_abnormal_body_temperature0.83996608
73MP0003634_abnormal_glial_cell0.83219485
74MP0004085_abnormal_heartbeat0.83092487
75MP0000604_amyloidosis0.83027812
76MP0003172_abnormal_lysosome_physiology0.80838404
77MP0005551_abnormal_eye_electrophysiolog0.80000478
78MP0001986_abnormal_taste_sensitivity0.78240247
79MP0010386_abnormal_urinary_bladder0.76915260
80MP0004742_abnormal_vestibular_system0.76619031
81* MP0001177_atelectasis0.76580876
82MP0002090_abnormal_vision0.75058848
83MP0005499_abnormal_olfactory_system0.74370317
84MP0005394_taste/olfaction_phenotype0.74370317
85MP0004510_myositis0.73675739
86MP0001963_abnormal_hearing_physiology0.70914701
87MP0003137_abnormal_impulse_conducting0.67717130
88MP0005409_darkened_coat_color0.65291495
89MP0010234_abnormal_vibrissa_follicle0.64767411
90MP0004043_abnormal_pH_regulation0.63941253
91MP0001485_abnormal_pinna_reflex0.63536073
92MP0004130_abnormal_muscle_cell0.63490882
93MP0000631_abnormal_neuroendocrine_gland0.62833629
94MP0000579_abnormal_nail_morphology0.62416797
95MP0008877_abnormal_DNA_methylation0.61701321
96MP0004215_abnormal_myocardial_fiber0.61144540
97* MP0002752_abnormal_somatic_nervous0.61085589
98MP0005166_decreased_susceptibility_to0.60498014
99MP0004233_abnormal_muscle_weight0.58555023
100MP0001299_abnormal_eye_distance/0.56335187
101MP0004484_altered_response_of0.55019039
102MP0005623_abnormal_meninges_morphology0.54733176
103MP0002638_abnormal_pupillary_reflex0.54463691
104* MP0010769_abnormal_survival0.54383858
105MP0001664_abnormal_digestion0.53718445
106MP0003045_fibrosis0.52482199
107* MP0003956_abnormal_body_size0.50900051
108* MP0010768_mortality/aging0.50863742
109* MP0002082_postnatal_lethality0.50405185
110* MP0010770_preweaning_lethality0.50405185
111* MP0001943_abnormal_respiration0.46263988
112MP0001765_abnormal_ion_homeostasis0.45138486
113* MP0002873_normal_phenotype0.44761905
114MP0003183_abnormal_peptide_metabolism0.44622559
115* MP0002169_no_abnormal_phenotype0.43081531
116MP0003861_abnormal_nervous_system0.42865486
117MP0000026_abnormal_inner_ear0.40838916
118MP0002089_abnormal_postnatal_growth/wei0.40633085

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.91274626
2Focal motor seizures (HP:0011153)7.74495499
3Focal seizures (HP:0007359)5.99615842
4Visual hallucinations (HP:0002367)5.52276321
5Action tremor (HP:0002345)4.68549500
6Epileptic encephalopathy (HP:0200134)4.64923391
7Progressive cerebellar ataxia (HP:0002073)4.64890268
8Febrile seizures (HP:0002373)4.37423706
9Atonic seizures (HP:0010819)4.19555405
10Absence seizures (HP:0002121)3.98104481
11Generalized tonic-clonic seizures (HP:0002069)3.89830450
12Ankle clonus (HP:0011448)3.84128748
13Supranuclear gaze palsy (HP:0000605)3.82171765
14Poor eye contact (HP:0000817)3.71053798
15Cerebral hypomyelination (HP:0006808)3.70979662
16Gaze-evoked nystagmus (HP:0000640)3.66470520
17Dialeptic seizures (HP:0011146)3.64949390
18Broad-based gait (HP:0002136)3.59691785
19Impaired vibration sensation in the lower limbs (HP:0002166)3.57303367
20Depression (HP:0000716)3.56604129
21Dysdiadochokinesis (HP:0002075)3.45159184
22Postural instability (HP:0002172)3.39131224
23Abnormal social behavior (HP:0012433)3.36801412
24Impaired social interactions (HP:0000735)3.36801412
25Urinary bladder sphincter dysfunction (HP:0002839)3.34699797
26Dysmetria (HP:0001310)3.34374868
27Papilledema (HP:0001085)3.32800509
28Mutism (HP:0002300)3.32623719
29Anxiety (HP:0000739)3.21401312
30Delusions (HP:0000746)3.21387551
31Abnormality of the lower motor neuron (HP:0002366)3.15051825
32Genetic anticipation (HP:0003743)3.12901946
33Impaired smooth pursuit (HP:0007772)3.08366897
34Torticollis (HP:0000473)3.08130804
35Abnormal eating behavior (HP:0100738)3.07184634
36Hemiplegia (HP:0002301)3.04024789
37Truncal ataxia (HP:0002078)3.03035836
38Intention tremor (HP:0002080)2.98548271
39Akinesia (HP:0002304)2.98115318
40Ventricular fibrillation (HP:0001663)2.96663804
41Annular pancreas (HP:0001734)2.86011051
42Focal dystonia (HP:0004373)2.85767258
43Scanning speech (HP:0002168)2.82667131
44Urinary urgency (HP:0000012)2.80052367
45Spastic gait (HP:0002064)2.74682955
46Hemiparesis (HP:0001269)2.72333406
47Abnormality of ocular smooth pursuit (HP:0000617)2.70559548
48Dysmetric saccades (HP:0000641)2.68468837
49Stereotypic behavior (HP:0000733)2.67065245
50Bradykinesia (HP:0002067)2.64160088
51Amblyopia (HP:0000646)2.63890071
52Diplopia (HP:0000651)2.62248950
53Abnormality of binocular vision (HP:0011514)2.62248950
54Craniofacial dystonia (HP:0012179)2.52039875
55Pointed chin (HP:0000307)2.48159828
56Sleep apnea (HP:0010535)2.47972032
57Hyperventilation (HP:0002883)2.46010723
58Diminished motivation (HP:0000745)2.45281777
59Status epilepticus (HP:0002133)2.44961484
60Peripheral hypomyelination (HP:0007182)2.44359218
61Spastic tetraparesis (HP:0001285)2.43916579
62Impaired vibratory sensation (HP:0002495)2.43883348
63Megalencephaly (HP:0001355)2.42296044
64Drooling (HP:0002307)2.40458360
65Excessive salivation (HP:0003781)2.40458360
66Choreoathetosis (HP:0001266)2.38883224
67Progressive inability to walk (HP:0002505)2.37751238
68Neurofibrillary tangles (HP:0002185)2.35953518
69Bundle branch block (HP:0011710)2.35205248
70Epileptiform EEG discharges (HP:0011182)2.32484331
71Insomnia (HP:0100785)2.32039067
72CNS hypomyelination (HP:0003429)2.25903124
73EEG with generalized epileptiform discharges (HP:0011198)2.24792750
74Cerebral inclusion bodies (HP:0100314)2.20485363
75Lower limb muscle weakness (HP:0007340)2.20097352
76Clonus (HP:0002169)2.20096776
77Fetal akinesia sequence (HP:0001989)2.17950853
78Hypsarrhythmia (HP:0002521)2.16426851
79Obstructive sleep apnea (HP:0002870)2.12157270
80Abnormal EKG (HP:0003115)2.09931181
81Incomplete penetrance (HP:0003829)2.06955709
82Abnormality of saccadic eye movements (HP:0000570)2.06891108
83Tetraplegia (HP:0002445)2.06598450
84Abnormality of the corticospinal tract (HP:0002492)2.05961410
85Morphological abnormality of the pyramidal tract (HP:0002062)2.04225689
86Agitation (HP:0000713)2.03977619
87Absent speech (HP:0001344)2.03757072
88Neuronal loss in central nervous system (HP:0002529)2.01601139
89Resting tremor (HP:0002322)2.01244550
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01011414
91Degeneration of the lateral corticospinal tracts (HP:0002314)2.01011414
92Generalized myoclonic seizures (HP:0002123)2.00619958
93Gait ataxia (HP:0002066)2.00376702
94Lower limb amyotrophy (HP:0007210)1.97697518
95Insidious onset (HP:0003587)1.95672943
96Termporal pattern (HP:0011008)1.95672943
97Limb dystonia (HP:0002451)1.92992074
98Ankyloglossia (HP:0010296)1.92477933
99Memory impairment (HP:0002354)1.92466365
100Rigidity (HP:0002063)1.90195611
101Lower limb asymmetry (HP:0100559)1.89601121
102Aplasia involving bones of the upper limbs (HP:0009823)1.87871733
103Aplasia of the phalanges of the hand (HP:0009802)1.87871733
104Aplasia involving bones of the extremities (HP:0009825)1.87871733
105Amyotrophic lateral sclerosis (HP:0007354)1.87239699
106Increased circulating renin level (HP:0000848)1.83896142
107Heart block (HP:0012722)1.83325519
108Polyphagia (HP:0002591)1.83043183
109Pheochromocytoma (HP:0002666)1.82724480
110Abnormality of the periventricular white matter (HP:0002518)1.80600450
111Inability to walk (HP:0002540)1.80159561
112Prolonged QT interval (HP:0001657)1.79507920
113Dementia (HP:0000726)1.78689050
114Upper limb amyotrophy (HP:0009129)1.78144391
115Distal upper limb amyotrophy (HP:0007149)1.78144391
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77847590
117Spinal canal stenosis (HP:0003416)1.76141164
118Slow saccadic eye movements (HP:0000514)1.75899269
119Psychosis (HP:0000709)1.75897099
120Hand muscle atrophy (HP:0009130)1.75726734
121Unsteady gait (HP:0002317)1.75009477
122Inappropriate behavior (HP:0000719)1.74609088
123Apathy (HP:0000741)1.74557961
124Rapidly progressive (HP:0003678)1.71266139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.75075959
2NTRK34.72478112
3MAP3K94.11022495
4MARK12.81589689
5DAPK22.78965013
6MAP3K42.70249914
7MINK12.68889944
8PRKD32.58277751
9PAK62.55590366
10KSR22.31577494
11CAMKK12.27225210
12NTRK22.13573890
13MAP2K72.11712178
14NTRK11.92731839
15RIPK41.77914776
16STK381.73717127
17MAP2K41.68774864
18CDK51.63466855
19DAPK11.61587858
20KSR11.59723541
21TNIK1.58507666
22PRPF4B1.44953691
23MAP3K121.42244519
24TAOK11.33617011
25CAMKK21.33307950
26MAP3K21.30652964
27MAP3K131.30571737
28CDK191.28489434
29FES1.28065740
30ARAF1.26936111
31TYRO31.26380614
32SIK21.25628403
33PRKCG1.24097470
34GRK51.21756595
35UHMK11.19509439
36MAPK131.15994799
37CAMK11.11626603
38PLK21.10587398
39PRKCH1.06096654
40ALK1.04198304
41PINK11.00188257
42STK110.99527483
43SGK4940.96156556
44SGK2230.96156556
45CDK150.95565423
46CDK180.95314378
47PHKG20.91693209
48PHKG10.91693209
49RIPK10.91685083
50MAPK120.89938374
51LATS20.88063299
52CAMK2A0.87929964
53CDK140.87430992
54RAF10.85665341
55PNCK0.85644865
56CDK11A0.84088761
57SGK30.82866399
58SGK20.82407612
59RET0.80952821
60LMTK20.79612034
61CASK0.78039493
62MARK20.76470630
63PDK10.75819365
64MAP3K110.75347871
65CAMK2B0.73751232
66PAK30.73640442
67SGK10.72564883
68PDPK10.68332662
69BRAF0.67195726
70MAP3K10.66756202
71TNK20.66447560
72NEK10.66245780
73CDC42BPA0.64638646
74DYRK1A0.63415566
75PKN10.62681669
76PTK2B0.62578722
77BRSK10.60799348
78BMPR20.60227499
79LIMK10.59460036
80SCYL20.57782345
81CAMK40.56139764
82WNK10.56093906
83OXSR10.53885821
84* RPS6KA30.53292769
85CSNK1G20.52649735
86MAP3K70.52454117
87CAMK1G0.51357488
88PRKCZ0.50077872
89MAPK100.48461993
90FYN0.48169725
91TESK10.46204797
92CAMK2G0.45870749
93PRKG20.44526960
94ROCK20.44505161
95DAPK30.42424099
96FGFR20.40282404
97CAMK2D0.39917579
98CCNB10.37038687
99PRKCE0.36316378
100MAP2K10.36228875
101DMPK0.34751176
102IRAK20.33061174
103* PRKCB0.30235630
104ROCK10.29882518
105RPS6KA20.29511731
106ERBB20.29416469
107PRKD20.28944173
108MAPK80.28170919
109MAP2K60.27789332
110* PRKCA0.27104931
111FER0.27098932
112CSNK1A10.24793390
113BMX0.23662320
114JAK20.23521544
115CAMK1D0.20820232
116GSK3B0.20275390
117MAPKAPK50.19793634

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050333.44494936
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32092298
3Olfactory transduction_Homo sapiens_hsa047402.92141976
4GABAergic synapse_Homo sapiens_hsa047272.76926639
5* Circadian entrainment_Homo sapiens_hsa047132.72668034
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62433152
7* Glutamatergic synapse_Homo sapiens_hsa047242.61213903
8* Long-term potentiation_Homo sapiens_hsa047202.59359373
9Morphine addiction_Homo sapiens_hsa050322.56666907
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36386166
11* Amphetamine addiction_Homo sapiens_hsa050312.35283138
12Salivary secretion_Homo sapiens_hsa049702.27146307
13Dopaminergic synapse_Homo sapiens_hsa047282.15845030
14Insulin secretion_Homo sapiens_hsa049112.14496288
15Cholinergic synapse_Homo sapiens_hsa047252.01502195
16Gastric acid secretion_Homo sapiens_hsa049711.99946400
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98700496
18Vitamin B6 metabolism_Homo sapiens_hsa007501.80104638
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76382342
20Oxytocin signaling pathway_Homo sapiens_hsa049211.69949505
21Taste transduction_Homo sapiens_hsa047421.67830572
22Long-term depression_Homo sapiens_hsa047301.67798733
23Renin secretion_Homo sapiens_hsa049241.60638740
24* Calcium signaling pathway_Homo sapiens_hsa040201.56978997
25Nitrogen metabolism_Homo sapiens_hsa009101.53426357
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51603449
27Serotonergic synapse_Homo sapiens_hsa047261.51537108
28* Cocaine addiction_Homo sapiens_hsa050301.49770293
29GnRH signaling pathway_Homo sapiens_hsa049121.49599376
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41504923
31Type II diabetes mellitus_Homo sapiens_hsa049301.37716501
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35139975
33Gap junction_Homo sapiens_hsa045401.34587086
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33061363
35* cAMP signaling pathway_Homo sapiens_hsa040241.29918847
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23484094
37Glioma_Homo sapiens_hsa052141.19295163
38Estrogen signaling pathway_Homo sapiens_hsa049151.17224620
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04938375
40Collecting duct acid secretion_Homo sapiens_hsa049661.04343844
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03351558
42ErbB signaling pathway_Homo sapiens_hsa040121.03244232
43Melanogenesis_Homo sapiens_hsa049161.02068321
44Axon guidance_Homo sapiens_hsa043600.99532561
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96776307
46Pancreatic secretion_Homo sapiens_hsa049720.95624522
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.94249320
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.93229024
49Oocyte meiosis_Homo sapiens_hsa041140.90547439
50Thyroid hormone synthesis_Homo sapiens_hsa049180.86131766
51* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85493845
52Cardiac muscle contraction_Homo sapiens_hsa042600.83964047
53Dorso-ventral axis formation_Homo sapiens_hsa043200.83707962
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77695436
55Dilated cardiomyopathy_Homo sapiens_hsa054140.75990274
56Choline metabolism in cancer_Homo sapiens_hsa052310.74517277
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73271562
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73001556
59MAPK signaling pathway_Homo sapiens_hsa040100.71785374
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.69863774
61Vibrio cholerae infection_Homo sapiens_hsa051100.67708506
62VEGF signaling pathway_Homo sapiens_hsa043700.65903682
63Bile secretion_Homo sapiens_hsa049760.64017371
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63553003
65Type I diabetes mellitus_Homo sapiens_hsa049400.62040728
66mTOR signaling pathway_Homo sapiens_hsa041500.61342090
67Phototransduction_Homo sapiens_hsa047440.60111277
68Endocytosis_Homo sapiens_hsa041440.56673132
69Glucagon signaling pathway_Homo sapiens_hsa049220.56155368
70Inositol phosphate metabolism_Homo sapiens_hsa005620.55412028
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54254663
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.54101996
73* Rap1 signaling pathway_Homo sapiens_hsa040150.53901869
74* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51783586
75Non-small cell lung cancer_Homo sapiens_hsa052230.51551827
76* Ras signaling pathway_Homo sapiens_hsa040140.50213297
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50104154
78Circadian rhythm_Homo sapiens_hsa047100.49660306
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48923666
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47073670
81Endometrial cancer_Homo sapiens_hsa052130.46496389
82Arginine biosynthesis_Homo sapiens_hsa002200.45185710
83* Alcoholism_Homo sapiens_hsa050340.44721170
84Arginine and proline metabolism_Homo sapiens_hsa003300.44669915
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44480673
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43664112
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43474224
88Prion diseases_Homo sapiens_hsa050200.42361583
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41414402
90Chemokine signaling pathway_Homo sapiens_hsa040620.41217118
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40436664
92Insulin signaling pathway_Homo sapiens_hsa049100.39525717
93Ovarian steroidogenesis_Homo sapiens_hsa049130.36878471
94Fatty acid biosynthesis_Homo sapiens_hsa000610.36581111
95Renal cell carcinoma_Homo sapiens_hsa052110.36000494
96Wnt signaling pathway_Homo sapiens_hsa043100.35996810
97Mineral absorption_Homo sapiens_hsa049780.35630033
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32565674
99African trypanosomiasis_Homo sapiens_hsa051430.32476997
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30800477
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.30414294
102Histidine metabolism_Homo sapiens_hsa003400.30238550
103HIF-1 signaling pathway_Homo sapiens_hsa040660.29804653
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29298578
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29166548
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28152663
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27623715
108AMPK signaling pathway_Homo sapiens_hsa041520.24015856
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21875621
110Tight junction_Homo sapiens_hsa045300.21741400
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19581052
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18297949
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17297960

Most similar genes based on co-expression Upload to Enrichr

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