GRIN2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.01979084
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.93443923
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82751365
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.71524169
5locomotory exploration behavior (GO:0035641)5.62840840
6* ionotropic glutamate receptor signaling pathway (GO:0035235)5.40218959
7synaptic vesicle exocytosis (GO:0016079)5.38961215
8regulation of glutamate receptor signaling pathway (GO:1900449)5.33281280
9neuron cell-cell adhesion (GO:0007158)5.32794102
10protein localization to synapse (GO:0035418)5.28218513
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.13957400
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.13454171
13glutamate secretion (GO:0014047)5.00107881
14* glutamate receptor signaling pathway (GO:0007215)4.92559123
15synaptic vesicle maturation (GO:0016188)4.82602725
16exploration behavior (GO:0035640)4.82475333
17neurotransmitter-gated ion channel clustering (GO:0072578)4.79041942
18* synaptic transmission, glutamatergic (GO:0035249)4.72836377
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72586076
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.63380660
21regulation of synaptic vesicle exocytosis (GO:2000300)4.60742277
22* neuron-neuron synaptic transmission (GO:0007270)4.54354522
23presynaptic membrane assembly (GO:0097105)4.44324229
24regulation of neuronal synaptic plasticity (GO:0048168)4.39256434
25neuronal action potential propagation (GO:0019227)4.36766477
26sodium ion export (GO:0071436)4.32338868
27positive regulation of synapse maturation (GO:0090129)4.28608730
28* regulation of excitatory postsynaptic membrane potential (GO:0060079)4.27160705
29response to histamine (GO:0034776)4.22826203
30regulation of synaptic vesicle transport (GO:1902803)4.19921399
31postsynaptic membrane organization (GO:0001941)4.13573794
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.09227512
33* regulation of postsynaptic membrane potential (GO:0060078)4.05302994
34positive regulation of membrane potential (GO:0045838)4.02281026
35long-term synaptic potentiation (GO:0060291)4.01283611
36neuron recognition (GO:0008038)4.01097300
37long-term memory (GO:0007616)4.00382797
38presynaptic membrane organization (GO:0097090)3.99228467
39pyrimidine nucleobase catabolic process (GO:0006208)3.96387053
40neurotransmitter secretion (GO:0007269)3.96350804
41regulation of synapse structural plasticity (GO:0051823)3.96319781
42* regulation of synaptic plasticity (GO:0048167)3.92175777
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91343479
44dendritic spine morphogenesis (GO:0060997)3.81583204
45regulation of dendritic spine morphogenesis (GO:0061001)3.81043486
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79558888
47L-amino acid import (GO:0043092)3.78095379
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73246970
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.72806453
50axonal fasciculation (GO:0007413)3.72714931
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69376794
52innervation (GO:0060384)3.69276949
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.67925362
54serotonin metabolic process (GO:0042428)3.62745550
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.62651049
56positive regulation of neurotransmitter secretion (GO:0001956)3.61177666
57* behavioral fear response (GO:0001662)3.55634071
58* behavioral defense response (GO:0002209)3.55634071
59cochlea development (GO:0090102)3.52290219
60neuronal ion channel clustering (GO:0045161)3.49165590
61gamma-aminobutyric acid transport (GO:0015812)3.47722724
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47120039
63positive regulation of potassium ion transmembrane transport (GO:1901381)3.46109108
64layer formation in cerebral cortex (GO:0021819)3.44267517
65regulation of synapse maturation (GO:0090128)3.40017737
66nucleobase catabolic process (GO:0046113)3.39868499
67transmission of nerve impulse (GO:0019226)3.38564082
68synaptic vesicle endocytosis (GO:0048488)3.37702115
69response to auditory stimulus (GO:0010996)3.37550062
70regulation of dendritic spine development (GO:0060998)3.36686812
71* membrane depolarization (GO:0051899)3.35437590
72establishment of mitochondrion localization (GO:0051654)3.35185843
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34809427
74proline transport (GO:0015824)3.33993530
75* learning (GO:0007612)3.32808999
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32245031
77cerebellar granule cell differentiation (GO:0021707)3.32102322
78cell communication by electrical coupling (GO:0010644)3.30772274
79* fear response (GO:0042596)3.29146490
80long term synaptic depression (GO:0060292)3.28840077
81regulation of neurotransmitter secretion (GO:0046928)3.26615819
82amino acid import (GO:0043090)3.26214389
83positive regulation of neurotransmitter transport (GO:0051590)3.25488295
84chemosensory behavior (GO:0007635)3.23836945
85cellular sodium ion homeostasis (GO:0006883)3.23753936
86cellular potassium ion homeostasis (GO:0030007)3.23227105
87regulation of vesicle fusion (GO:0031338)3.21005464
88neurotransmitter transport (GO:0006836)3.19624465
89membrane depolarization during action potential (GO:0086010)3.18713217
90cell communication involved in cardiac conduction (GO:0086065)3.18479338
91* startle response (GO:0001964)3.17806872
92cerebellar Purkinje cell differentiation (GO:0021702)3.17190959
93positive regulation of dendritic spine morphogenesis (GO:0061003)3.17121710
94regulation of female receptivity (GO:0045924)3.16676391
95dendritic spine organization (GO:0097061)3.15789386
96positive regulation of synapse assembly (GO:0051965)3.15771664
97neuronal action potential (GO:0019228)3.15384175
98positive regulation of synaptic transmission (GO:0050806)3.14118364
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10042256
100regulation of neurotransmitter transport (GO:0051588)3.09242486
101positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09073714
102* synaptic transmission (GO:0007268)3.09024498
103* regulation of synaptic transmission (GO:0050804)3.09023491
104negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08897766
105negative regulation of dendrite morphogenesis (GO:0050774)3.08155733
106regulation of glutamate secretion (GO:0014048)3.07907373
107membrane hyperpolarization (GO:0060081)3.07810593
108cell migration in hindbrain (GO:0021535)3.07520681
109positive regulation of dendritic spine development (GO:0060999)3.07480344
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06279245
111central nervous system projection neuron axonogenesis (GO:0021952)3.05988821
112adult walking behavior (GO:0007628)3.05368135
113primary amino compound metabolic process (GO:1901160)3.04816768
114regulation of voltage-gated calcium channel activity (GO:1901385)3.04023907
115synapse assembly (GO:0007416)3.03778189
116mechanosensory behavior (GO:0007638)3.02626384
117potassium ion homeostasis (GO:0055075)3.02017228
118auditory behavior (GO:0031223)3.01902239
119neuromuscular process controlling balance (GO:0050885)3.00443054
120negative regulation of dendrite development (GO:2000171)3.00143735
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00051285
122dendrite morphogenesis (GO:0048813)2.98741758
123activation of protein kinase A activity (GO:0034199)2.98093986
124behavioral response to cocaine (GO:0048148)2.97746624
125central nervous system neuron axonogenesis (GO:0021955)2.97515006
126regulation of neurotransmitter levels (GO:0001505)2.97371149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52804134
2GBX2_23144817_ChIP-Seq_PC3_Human4.53712520
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12143592
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06333321
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02430315
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65737445
7REST_21632747_ChIP-Seq_MESCs_Mouse2.64052397
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52704957
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52704957
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50008123
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49829605
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42223463
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.42075124
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35888830
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35011209
16DROSHA_22980978_ChIP-Seq_HELA_Human2.33977140
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32832843
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32123042
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25629307
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16958915
21TAF15_26573619_Chip-Seq_HEK293_Human2.16050313
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13088050
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06419822
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.05494590
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03109295
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.01231919
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96595732
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95868714
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94811719
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.92090190
31AR_21572438_ChIP-Seq_LNCaP_Human1.89103516
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82446501
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80502902
34* P300_19829295_ChIP-Seq_ESCs_Human1.75422652
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71522966
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69441389
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61655355
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60716018
39* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53954525
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48486334
41ZNF274_21170338_ChIP-Seq_K562_Hela1.46446564
42* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46172711
43* FUS_26573619_Chip-Seq_HEK293_Human1.44043163
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.42635558
45* AR_25329375_ChIP-Seq_VCAP_Human1.40837096
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.39596872
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39337992
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.38861107
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38545479
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.38507368
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37862429
52* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37803875
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37583087
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36348648
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36133966
56IGF1R_20145208_ChIP-Seq_DFB_Human1.35681729
57* STAT3_23295773_ChIP-Seq_U87_Human1.34707815
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31428649
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28505515
60TP53_16413492_ChIP-PET_HCT116_Human1.28149263
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26183455
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25919130
63TCF4_23295773_ChIP-Seq_U87_Human1.24962598
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.24147845
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22831060
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22564987
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21920150
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.20175555
69AR_19668381_ChIP-Seq_PC3_Human1.20057480
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19144724
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19119605
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18302803
73* PRDM14_20953172_ChIP-Seq_ESCs_Human1.16819369
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.15714861
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15541153
76RNF2_27304074_Chip-Seq_NSC_Mouse1.15331247
77VDR_22108803_ChIP-Seq_LS180_Human1.14497046
78AHR_22903824_ChIP-Seq_MCF-7_Human1.13929516
79TP53_18474530_ChIP-ChIP_U2OS_Human1.11181906
80JUN_21703547_ChIP-Seq_K562_Human1.10696351
81* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10660777
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10371446
83* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10198891
84RUNX2_22187159_ChIP-Seq_PCA_Human1.10023646
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09278926
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08667714
87KDM2B_26808549_Chip-Seq_REH_Human1.08449618
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.07342502
89SOX9_26525672_Chip-Seq_HEART_Mouse1.06786202
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06494778
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06417242
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05531967
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05210228
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04747612
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04747612
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03988416
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03581940
98ER_23166858_ChIP-Seq_MCF-7_Human1.02257292
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01330209
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99890670
101CBP_20019798_ChIP-Seq_JUKART_Human0.99890670
102* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98665760
103* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98422805
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98356113
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97316345
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97002609
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.96799820
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96611745
109RXR_22108803_ChIP-Seq_LS180_Human0.96600766
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96473526
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.94284766
112* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93872762
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93113999
114* BCAT_22108803_ChIP-Seq_LS180_Human0.92720785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity6.73395304
2MP0003880_abnormal_central_pattern5.61135489
3* MP0003635_abnormal_synaptic_transmissio4.38522069
4MP0004270_analgesia4.02570873
5MP0009745_abnormal_behavioral_response3.72317685
6* MP0002063_abnormal_learning/memory/cond3.63985047
7MP0002064_seizures3.31651110
8MP0001968_abnormal_touch/_nociception3.26579083
9* MP0002572_abnormal_emotion/affect_behav3.07163709
10MP0009046_muscle_twitch2.95949535
11MP0002736_abnormal_nociception_after2.66430582
12MP0002272_abnormal_nervous_system2.65430754
13MP0002822_catalepsy2.57157596
14MP0001486_abnormal_startle_reflex2.54821008
15MP0002735_abnormal_chemical_nociception2.50620305
16MP0002734_abnormal_mechanical_nocicepti2.48211484
17MP0001501_abnormal_sleep_pattern2.45766215
18MP0001440_abnormal_grooming_behavior2.27673543
19MP0005423_abnormal_somatic_nervous2.25553795
20MP0009780_abnormal_chondrocyte_physiolo2.06974064
21MP0002067_abnormal_sensory_capabilities2.03578871
22MP0003879_abnormal_hair_cell1.92919651
23MP0000778_abnormal_nervous_system1.92319353
24MP0003787_abnormal_imprinting1.90743244
25MP0002733_abnormal_thermal_nociception1.87274544
26MP0001970_abnormal_pain_threshold1.84164468
27MP0002184_abnormal_innervation1.81797071
28MP0005646_abnormal_pituitary_gland1.76960518
29MP0005386_behavior/neurological_phenoty1.73862199
30MP0004924_abnormal_behavior1.73862199
31MP0002557_abnormal_social/conspecific_i1.73225418
32MP0004811_abnormal_neuron_physiology1.70476431
33MP0008569_lethality_at_weaning1.65351587
34MP0001529_abnormal_vocalization1.63558043
35MP0001188_hyperpigmentation1.61977049
36MP0003329_amyloid_beta_deposits1.59093900
37MP0006276_abnormal_autonomic_nervous1.58864699
38MP0001984_abnormal_olfaction1.48300148
39MP0004858_abnormal_nervous_system1.43106048
40MP0002909_abnormal_adrenal_gland1.43036003
41* MP0002066_abnormal_motor_capabilities/c1.37987061
42MP0000955_abnormal_spinal_cord1.36009178
43* MP0002882_abnormal_neuron_morphology1.33507835
44MP0001905_abnormal_dopamine_level1.30654409
45MP0005645_abnormal_hypothalamus_physiol1.21531692
46* MP0003633_abnormal_nervous_system1.20445531
47MP0004885_abnormal_endolymph1.14278756
48MP0003121_genomic_imprinting1.13246978
49MP0004142_abnormal_muscle_tone1.11901579
50MP0001502_abnormal_circadian_rhythm1.10807522
51* MP0002152_abnormal_brain_morphology1.07569051
52MP0002837_dystrophic_cardiac_calcinosis1.06737141
53* MP0003631_nervous_system_phenotype1.04226645
54MP0003122_maternal_imprinting1.02132211
55MP0008872_abnormal_physiological_respon1.01707300
56MP0002638_abnormal_pupillary_reflex1.00956661
57MP0000569_abnormal_digit_pigmentation1.00225009
58MP0002876_abnormal_thyroid_physiology0.96397924
59MP0010386_abnormal_urinary_bladder0.95362148
60MP0004145_abnormal_muscle_electrophysio0.93951321
61MP0004085_abnormal_heartbeat0.92064740
62MP0000751_myopathy0.92044562
63* MP0002069_abnormal_eating/drinking_beha0.91497736
64MP0001963_abnormal_hearing_physiology0.90513953
65MP0004484_altered_response_of0.90107112
66MP0004510_myositis0.87932866
67MP0005409_darkened_coat_color0.87877127
68* MP0008874_decreased_physiological_sensi0.84754967
69MP0004215_abnormal_myocardial_fiber0.84208926
70MP0002229_neurodegeneration0.84143291
71MP0005187_abnormal_penis_morphology0.82515664
72MP0004147_increased_porphyrin_level0.82455008
73MP0001177_atelectasis0.81090766
74MP0004742_abnormal_vestibular_system0.80539362
75MP0003123_paternal_imprinting0.80134025
76MP0005551_abnormal_eye_electrophysiolog0.80058803
77MP0005535_abnormal_body_temperature0.74534625
78MP0001664_abnormal_digestion0.72600072
79MP0001485_abnormal_pinna_reflex0.72384312
80MP0000631_abnormal_neuroendocrine_gland0.71913462
81MP0005171_absent_coat_pigmentation0.71820818
82MP0003075_altered_response_to0.70698704
83MP0003119_abnormal_digestive_system0.69418872
84MP0003632_abnormal_nervous_system0.69264182
85MP0001986_abnormal_taste_sensitivity0.68795356
86MP0002752_abnormal_somatic_nervous0.67964138
87MP0002102_abnormal_ear_morphology0.67256226
88MP0005499_abnormal_olfactory_system0.66767666
89MP0005394_taste/olfaction_phenotype0.66767666
90MP0000604_amyloidosis0.65271371
91MP0004043_abnormal_pH_regulation0.62689111
92MP0002234_abnormal_pharynx_morphology0.60259567
93MP0004130_abnormal_muscle_cell0.60026555
94MP0006292_abnormal_olfactory_placode0.59801304
95MP0003890_abnormal_embryonic-extraembry0.58866360
96MP0002751_abnormal_autonomic_nervous0.57963142
97MP0000026_abnormal_inner_ear0.57833791
98MP0003634_abnormal_glial_cell0.57828220
99MP0008877_abnormal_DNA_methylation0.57658006
100MP0001299_abnormal_eye_distance/0.55709837
101MP0000013_abnormal_adipose_tissue0.55279855
102MP0003938_abnormal_ear_development0.55030087
103MP0003861_abnormal_nervous_system0.53900737
104MP0004233_abnormal_muscle_weight0.53613260
105MP0001765_abnormal_ion_homeostasis0.52250990
106MP0001943_abnormal_respiration0.52152008
107* MP0010769_abnormal_survival0.50748661
108* MP0002082_postnatal_lethality0.50154618
109* MP0010770_preweaning_lethality0.50154618
110MP0003283_abnormal_digestive_organ0.49714370
111MP0003137_abnormal_impulse_conducting0.49401766
112MP0003956_abnormal_body_size0.49221340
113* MP0002081_perinatal_lethality0.49101029
114MP0005248_abnormal_Harderian_gland0.48925033
115* MP0010768_mortality/aging0.47816646
116MP0003690_abnormal_glial_cell0.47502161
117MP0000920_abnormal_myelination0.47288014
118MP0008961_abnormal_basal_metabolism0.47242797

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.83122707
2Myokymia (HP:0002411)6.44937229
3Focal seizures (HP:0007359)6.42664875
4Epileptic encephalopathy (HP:0200134)6.10087864
5Hyperventilation (HP:0002883)5.59189801
6Atonic seizures (HP:0010819)5.16906169
7Febrile seizures (HP:0002373)4.96849352
8Absence seizures (HP:0002121)4.83468714
9Progressive cerebellar ataxia (HP:0002073)4.63447559
10Dialeptic seizures (HP:0011146)4.55098328
11Visual hallucinations (HP:0002367)4.54993632
12Broad-based gait (HP:0002136)4.38996765
13Generalized tonic-clonic seizures (HP:0002069)4.17480799
14Gaze-evoked nystagmus (HP:0000640)3.78415072
15Poor eye contact (HP:0000817)3.68417714
16Limb dystonia (HP:0002451)3.59632535
17Drooling (HP:0002307)3.53413777
18Excessive salivation (HP:0003781)3.53413777
19Amblyopia (HP:0000646)3.51651396
20Impaired vibration sensation in the lower limbs (HP:0002166)3.46452289
21Epileptiform EEG discharges (HP:0011182)3.35249210
22Impaired social interactions (HP:0000735)3.28465614
23Abnormal social behavior (HP:0012433)3.28465614
24Truncal ataxia (HP:0002078)3.18146920
25Action tremor (HP:0002345)3.14938055
26Dysmetria (HP:0001310)3.11256428
27Dysdiadochokinesis (HP:0002075)3.04420660
28Absent speech (HP:0001344)3.01942366
29Genetic anticipation (HP:0003743)2.87526720
30Protruding tongue (HP:0010808)2.86927159
31Urinary bladder sphincter dysfunction (HP:0002839)2.86563018
32Impaired smooth pursuit (HP:0007772)2.85772908
33Depression (HP:0000716)2.81353148
34Supranuclear gaze palsy (HP:0000605)2.80617687
35Anxiety (HP:0000739)2.76529954
36EEG with generalized epileptiform discharges (HP:0011198)2.74334907
37Scanning speech (HP:0002168)2.73918657
38Abnormal eating behavior (HP:0100738)2.68682629
39Inability to walk (HP:0002540)2.66794303
40Stereotypic behavior (HP:0000733)2.63880353
41Dysmetric saccades (HP:0000641)2.61734488
42Postural instability (HP:0002172)2.52354367
43Hypsarrhythmia (HP:0002521)2.52066371
44Diplopia (HP:0000651)2.49952282
45Abnormality of binocular vision (HP:0011514)2.49952282
46Impaired vibratory sensation (HP:0002495)2.46551806
47Blue irides (HP:0000635)2.44681588
48Abnormality of the lower motor neuron (HP:0002366)2.44014999
49Abnormality of ocular smooth pursuit (HP:0000617)2.42968075
50Mutism (HP:0002300)2.42259141
51Progressive inability to walk (HP:0002505)2.41525061
52Abnormality of salivation (HP:0100755)2.39976963
53Focal dystonia (HP:0004373)2.36087795
54Cerebral inclusion bodies (HP:0100314)2.34201998
55Hemiparesis (HP:0001269)2.34173611
56Termporal pattern (HP:0011008)2.33587355
57Insidious onset (HP:0003587)2.33587355
58Torticollis (HP:0000473)2.30817876
59Fair hair (HP:0002286)2.30082503
60Fetal akinesia sequence (HP:0001989)2.29983630
61Akinesia (HP:0002304)2.29852156
62Ankle clonus (HP:0011448)2.28967189
63Generalized myoclonic seizures (HP:0002123)2.27074674
64Bradykinesia (HP:0002067)2.26005975
65Papilledema (HP:0001085)2.25544077
66Urinary urgency (HP:0000012)2.25258050
67Generalized hypopigmentation of hair (HP:0011358)2.24704618
68Inappropriate behavior (HP:0000719)2.22121367
69Status epilepticus (HP:0002133)2.21593168
70Incomplete penetrance (HP:0003829)2.17692420
71Polyphagia (HP:0002591)2.13629745
72Spastic tetraplegia (HP:0002510)2.12051632
73Hepatoblastoma (HP:0002884)2.11768851
74Spastic gait (HP:0002064)2.08715057
75Thickened helices (HP:0000391)2.08293509
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07843463
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.07843463
78Sleep apnea (HP:0010535)2.07270625
79Abnormality of the corticospinal tract (HP:0002492)2.04104706
80Agitation (HP:0000713)2.02405456
81Gait ataxia (HP:0002066)2.02164088
82Widely spaced teeth (HP:0000687)2.01699262
83Neuroendocrine neoplasm (HP:0100634)2.00811823
84Neurofibrillary tangles (HP:0002185)2.00358269
85Prolonged QT interval (HP:0001657)1.96397308
86Morphological abnormality of the pyramidal tract (HP:0002062)1.95357860
87Craniofacial dystonia (HP:0012179)1.92391326
88Gait imbalance (HP:0002141)1.92049332
89Hydroureter (HP:0000072)1.91540565
90Pheochromocytoma (HP:0002666)1.90531119
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87706871
92Intention tremor (HP:0002080)1.86926804
93Hypoplasia of the corpus callosum (HP:0002079)1.84016899
94Clumsiness (HP:0002312)1.83800733
95Obstructive sleep apnea (HP:0002870)1.83307714
96Amyotrophic lateral sclerosis (HP:0007354)1.80728069
97Exotropia (HP:0000577)1.79501228
98Lower limb amyotrophy (HP:0007210)1.78557465
99Gastroesophageal reflux (HP:0002020)1.78516913
100Psychosis (HP:0000709)1.78316954
101Hemiplegia (HP:0002301)1.78254107
102Intellectual disability, severe (HP:0010864)1.77249318
103Lower limb muscle weakness (HP:0007340)1.76388416
104Autism (HP:0000717)1.75792601
105Megalencephaly (HP:0001355)1.73463408
106Absent/shortened dynein arms (HP:0200106)1.71980301
107Dynein arm defect of respiratory motile cilia (HP:0012255)1.71980301
108Spastic tetraparesis (HP:0001285)1.71540626
109Deeply set eye (HP:0000490)1.70991214
110Lissencephaly (HP:0001339)1.70843089
111Split foot (HP:0001839)1.70731751
112Delusions (HP:0000746)1.68854945
113Clonus (HP:0002169)1.68713643
114Specific learning disability (HP:0001328)1.68459425
115Syncope (HP:0001279)1.67662385
116Aqueductal stenosis (HP:0002410)1.66895218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.34454151
2EPHA45.24360047
3CASK3.56494894
4MAP3K43.08358619
5MAP3K92.95912187
6MAP2K72.84544403
7MARK12.82333885
8RIPK42.53576117
9DAPK22.47859482
10MINK12.42942368
11MAP3K122.38787300
12TNIK1.99005672
13PLK21.92912169
14MAP2K41.89451970
15CDK191.81326164
16KSR11.80185946
17NTRK21.76834141
18PRPF4B1.76246670
19PAK61.68851264
20KSR21.59016459
21MAPK131.56237252
22CDK51.47670629
23CAMKK11.41497286
24FRK1.32202817
25SIK21.31189925
26* DAPK11.28839125
27AKT31.28039369
28PNCK1.27170538
29SIK31.24897251
30FES1.24228590
31PINK11.22972431
32PRKD31.22960101
33NTRK11.21982634
34* CAMK2A1.21963215
35BMPR21.18381762
36GRK51.15440914
37PTK2B1.14575169
38* PRKCG1.11442559
39CCNB11.07387988
40SGK21.04914466
41DYRK21.00466442
42* CAMK2B1.00264031
43OXSR10.96443252
44ARAF0.96436127
45CAMKK20.94689718
46STK380.94176975
47CDK180.92928365
48SGK2230.92282778
49SGK4940.92282778
50MAP3K20.92000153
51NME10.88955273
52RAF10.88104374
53CAMK10.86970152
54CDK150.85959203
55SGK10.84318255
56CDK140.83542085
57MAP3K130.79184345
58PKN10.77224419
59CDK11A0.74217932
60SGK30.73328290
61FGR0.69583159
62UHMK10.69492479
63STK110.68403480
64CSNK1A1L0.68079854
65PDK10.66370083
66EPHA30.65558047
67DYRK1A0.62172604
68PRKCE0.61573351
69MARK20.61326976
70CSNK1G20.60057751
71TYRO30.59498925
72PAK30.58388625
73MAP3K60.56975836
74BCR0.56772566
75MAP4K20.54810504
76LATS20.54736121
77CSNK1G30.54327900
78CAMK2D0.54190132
79PDPK10.52281333
80WNK30.51749965
81RET0.51535678
82TAOK10.51348269
83PHKG10.51146901
84PHKG20.51146901
85STK390.50163651
86FER0.49977471
87PRKCH0.49811572
88CSNK1D0.49695003
89BRAF0.49234659
90ADRBK20.46876868
91PRKCZ0.45809941
92INSRR0.45676293
93CSNK1G10.44907058
94MAP3K70.44880591
95* RPS6KA30.42650603
96MAPK120.42420259
97CAMK2G0.41528669
98ERBB30.39657290
99DMPK0.38142243
100DAPK30.37679366
101CAMK40.37543746
102TRIM280.37477878
103NEK60.37097768
104* FYN0.35234072
105MAP3K10.35218275
106MAP2K10.35201897
107CSNK1E0.35144354
108MAPK100.33248599
109CSNK1A10.33052150
110TNK20.31924583
111BMPR1B0.31651230
112ALK0.31592766
113CDK30.31135657
114GRK70.30942971
115CAMK1G0.29963068
116* PRKCB0.29548391
117GSK3B0.29224770
118PRKG10.29066054
119PRKACA0.28402111
120* PRKCA0.28094630
121ERBB20.27187116
122ROCK20.27070573

Predicted pathways (KEGG)

RankGene SetZ-score
1* Nicotine addiction_Homo sapiens_hsa050334.38307387
2* Long-term potentiation_Homo sapiens_hsa047203.08773476
3Synaptic vesicle cycle_Homo sapiens_hsa047213.03390697
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00859098
5* Circadian entrainment_Homo sapiens_hsa047132.94335751
6* Amphetamine addiction_Homo sapiens_hsa050312.75826807
7* Glutamatergic synapse_Homo sapiens_hsa047242.75001014
8GABAergic synapse_Homo sapiens_hsa047272.69129388
9Morphine addiction_Homo sapiens_hsa050322.68004733
10Olfactory transduction_Homo sapiens_hsa047402.62314127
11Salivary secretion_Homo sapiens_hsa049702.40145739
12* Dopaminergic synapse_Homo sapiens_hsa047282.22740397
13Insulin secretion_Homo sapiens_hsa049111.98841789
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96707303
15Taste transduction_Homo sapiens_hsa047421.96601577
16Renin secretion_Homo sapiens_hsa049241.90116217
17Cholinergic synapse_Homo sapiens_hsa047251.90029227
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88218007
19Calcium signaling pathway_Homo sapiens_hsa040201.87725454
20Long-term depression_Homo sapiens_hsa047301.87054360
21Serotonergic synapse_Homo sapiens_hsa047261.86996797
22Gastric acid secretion_Homo sapiens_hsa049711.85090099
23Collecting duct acid secretion_Homo sapiens_hsa049661.75528648
24Oxytocin signaling pathway_Homo sapiens_hsa049211.75055088
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53664847
26* Cocaine addiction_Homo sapiens_hsa050301.42175020
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41600511
28GnRH signaling pathway_Homo sapiens_hsa049121.37803637
29* cAMP signaling pathway_Homo sapiens_hsa040241.33178153
30Gap junction_Homo sapiens_hsa045401.29348250
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27330859
32Axon guidance_Homo sapiens_hsa043601.24844286
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24529909
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19605939
35Glioma_Homo sapiens_hsa052141.16435167
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15040165
37Type II diabetes mellitus_Homo sapiens_hsa049301.14650574
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12158200
39Estrogen signaling pathway_Homo sapiens_hsa049151.09677063
40ErbB signaling pathway_Homo sapiens_hsa040121.06382458
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06202897
42Vibrio cholerae infection_Homo sapiens_hsa051101.05042422
43Melanogenesis_Homo sapiens_hsa049161.04170065
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00676454
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.99160608
46Phototransduction_Homo sapiens_hsa047440.88749262
47Pancreatic secretion_Homo sapiens_hsa049720.88717669
48* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87843253
49Cardiac muscle contraction_Homo sapiens_hsa042600.85719358
50Oocyte meiosis_Homo sapiens_hsa041140.82980884
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81171663
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77972198
53Choline metabolism in cancer_Homo sapiens_hsa052310.75310421
54MAPK signaling pathway_Homo sapiens_hsa040100.72147871
55Thyroid hormone synthesis_Homo sapiens_hsa049180.69052715
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.67900869
57African trypanosomiasis_Homo sapiens_hsa051430.67873332
58Dilated cardiomyopathy_Homo sapiens_hsa054140.66185780
59VEGF signaling pathway_Homo sapiens_hsa043700.65643591
60Dorso-ventral axis formation_Homo sapiens_hsa043200.64716521
61Glucagon signaling pathway_Homo sapiens_hsa049220.62821524
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61727606
63* Ras signaling pathway_Homo sapiens_hsa040140.61682041
64Vitamin B6 metabolism_Homo sapiens_hsa007500.60942399
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58225904
66Alzheimers disease_Homo sapiens_hsa050100.53777778
67* Rap1 signaling pathway_Homo sapiens_hsa040150.53583189
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53359992
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53098432
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.51145169
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48432689
72Wnt signaling pathway_Homo sapiens_hsa043100.46966129
73Hippo signaling pathway_Homo sapiens_hsa043900.46729102
74Circadian rhythm_Homo sapiens_hsa047100.46048091
75mTOR signaling pathway_Homo sapiens_hsa041500.44699956
76Fatty acid biosynthesis_Homo sapiens_hsa000610.42594248
77Butanoate metabolism_Homo sapiens_hsa006500.42409465
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42380214
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.42145353
80Inositol phosphate metabolism_Homo sapiens_hsa005620.41898126
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41758099
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41371712
83Type I diabetes mellitus_Homo sapiens_hsa049400.40230947
84Tight junction_Homo sapiens_hsa045300.40016289
85Non-small cell lung cancer_Homo sapiens_hsa052230.39086154
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38883942
87* Alcoholism_Homo sapiens_hsa050340.37596782
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34675569
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32405453
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30867581
91Oxidative phosphorylation_Homo sapiens_hsa001900.30676186
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30175260
93Endometrial cancer_Homo sapiens_hsa052130.30076075
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29958842
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29838110
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29216411
97Prion diseases_Homo sapiens_hsa050200.29040623
98Rheumatoid arthritis_Homo sapiens_hsa053230.28725371
99Prolactin signaling pathway_Homo sapiens_hsa049170.28653213
100Colorectal cancer_Homo sapiens_hsa052100.28546749
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27785820
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27568736
103Renal cell carcinoma_Homo sapiens_hsa052110.27538099
104Insulin signaling pathway_Homo sapiens_hsa049100.26787964
105Ovarian steroidogenesis_Homo sapiens_hsa049130.26284716
106Bile secretion_Homo sapiens_hsa049760.26195955
107Endocytosis_Homo sapiens_hsa041440.26103379
108Ether lipid metabolism_Homo sapiens_hsa005650.25372514
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25133756
110Hedgehog signaling pathway_Homo sapiens_hsa043400.23132960
111Mineral absorption_Homo sapiens_hsa049780.20850197
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20805171

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