GRIN3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.90953960
2left/right pattern formation (GO:0060972)8.49597771
3regulation of cilium movement (GO:0003352)6.17485495
4tolerance induction (GO:0002507)5.74646287
5negative regulation of T cell differentiation in thymus (GO:0033085)5.59081780
6primary alcohol catabolic process (GO:0034310)5.52622737
7intraciliary transport (GO:0042073)5.49816964
8left/right axis specification (GO:0070986)5.48155865
9ventricular system development (GO:0021591)5.45585663
10sarcomere organization (GO:0045214)5.41717531
11cardiac myofibril assembly (GO:0055003)5.31368464
12cilium organization (GO:0044782)5.27778300
13plasma membrane repair (GO:0001778)5.19641016
14cilium assembly (GO:0042384)5.10286299
15establishment of apical/basal cell polarity (GO:0035089)5.07744279
16microtubule bundle formation (GO:0001578)5.05877774
17centriole assembly (GO:0098534)4.84399168
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.61899309
19vitamin transmembrane transport (GO:0035461)4.58465289
20myofibril assembly (GO:0030239)4.57617546
21regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.47439546
22establishment of monopolar cell polarity (GO:0061162)4.44443619
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.44443619
24response to xenobiotic stimulus (GO:0009410)4.39136482
25lung epithelium development (GO:0060428)4.18276529
26protein localization to cilium (GO:0061512)4.17022971
27negative regulation of potassium ion transmembrane transport (GO:1901380)4.09324784
28carnitine shuttle (GO:0006853)4.09320707
29ethanol metabolic process (GO:0006067)4.08378009
30diterpenoid biosynthetic process (GO:0016102)4.07684498
31nucleoside diphosphate phosphorylation (GO:0006165)4.06139829
32cilium morphogenesis (GO:0060271)4.02558944
33cellular component assembly involved in morphogenesis (GO:0010927)3.87317633
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.87071424
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.85342946
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.78681632
37regulation of microtubule-based movement (GO:0060632)3.78394198
38positive regulation of tolerance induction (GO:0002645)3.76609436
39carnitine transmembrane transport (GO:1902603)3.72594977
40pyrimidine-containing compound transmembrane transport (GO:0072531)3.70796317
41cardiac muscle contraction (GO:0060048)3.66426294
42fatty acid transmembrane transport (GO:1902001)3.66088922
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.62982824
44amino-acid betaine transport (GO:0015838)3.61494625
45carnitine transport (GO:0015879)3.61494625
46regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.61392969
47regulation of interleukin-5 production (GO:0032674)3.58191856
48microtubule-based movement (GO:0007018)3.57522299
49cardiac muscle cell development (GO:0055013)3.57061868
50positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56670793
51lateral sprouting from an epithelium (GO:0060601)3.53832384
52negative regulation of immunoglobulin mediated immune response (GO:0002890)3.53719679
53negative regulation of B cell mediated immunity (GO:0002713)3.53719679
54establishment of tissue polarity (GO:0007164)3.50920497
55establishment of planar polarity (GO:0001736)3.50920497
56cellular response to ATP (GO:0071318)3.50131584
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.48491514
58GTP biosynthetic process (GO:0006183)3.45517951
59one-carbon compound transport (GO:0019755)3.44418604
60adult heart development (GO:0007512)3.43048997
61glomerular epithelial cell development (GO:0072310)3.42774223
62cell projection assembly (GO:0030031)3.42125166
63positive regulation of histone deacetylation (GO:0031065)3.41373715
64actomyosin structure organization (GO:0031032)3.38644057
65ventricular cardiac muscle cell action potential (GO:0086005)3.38388222
66actin-myosin filament sliding (GO:0033275)3.35742840
67muscle filament sliding (GO:0030049)3.35742840
68negative regulation of cell size (GO:0045792)3.35651143
69cardiac cell development (GO:0055006)3.35506723
70regulation of germinal center formation (GO:0002634)3.35425742
71viral transcription (GO:0019083)3.34191053
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33619111
73growth hormone secretion (GO:0030252)3.31988719
74acrosome reaction (GO:0007340)3.31835841
75sperm capacitation (GO:0048240)3.31016346
76regulation of membrane repolarization (GO:0060306)3.29926110
77positive regulation of glycogen biosynthetic process (GO:0045725)3.29816277
78determination of left/right symmetry (GO:0007368)3.28829070
79terpenoid biosynthetic process (GO:0016114)3.27575115
80regulation of the force of heart contraction (GO:0002026)3.26464689
81regulation of skeletal muscle contraction (GO:0014819)3.24108110
82protein localization to endosome (GO:0036010)3.23610891
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23303799
84glutathione derivative metabolic process (GO:1901685)3.20244618
85glutathione derivative biosynthetic process (GO:1901687)3.20244618
86regulation of tight junction assembly (GO:2000810)3.19058719
872-oxoglutarate metabolic process (GO:0006103)3.17677784
88retinoic acid metabolic process (GO:0042573)3.17202092
89translational termination (GO:0006415)3.13142522
904-hydroxyproline metabolic process (GO:0019471)3.11746055
91UTP biosynthetic process (GO:0006228)3.09139735
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06976472
93actin-mediated cell contraction (GO:0070252)3.06662218
94cardiac muscle hypertrophy (GO:0003300)3.06329291
95creatine metabolic process (GO:0006600)3.05808771
96actin filament-based movement (GO:0030048)3.05307256
97determination of bilateral symmetry (GO:0009855)3.04169675
98microtubule depolymerization (GO:0007019)3.03107970
99hydrogen peroxide biosynthetic process (GO:0050665)3.02985869
100cell communication by electrical coupling (GO:0010644)2.99393162
101ribosomal small subunit biogenesis (GO:0042274)2.99217780
102water-soluble vitamin biosynthetic process (GO:0042364)2.97551361
103specification of symmetry (GO:0009799)2.96654177
104smoothened signaling pathway (GO:0007224)2.93285365
105membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.92821019
106UTP metabolic process (GO:0046051)2.90532339
107motile cilium assembly (GO:0044458)2.90383901
108positive regulation of glycogen metabolic process (GO:0070875)2.88559160
109phosphatidylcholine biosynthetic process (GO:0006656)2.87807231
110urinary tract smooth muscle contraction (GO:0014848)2.87766858
111nonmotile primary cilium assembly (GO:0035058)2.86614128
112binding of sperm to zona pellucida (GO:0007339)2.85317064
113exogenous drug catabolic process (GO:0042738)2.84696549
114ATP synthesis coupled proton transport (GO:0015986)2.84484594
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84484594
116sarcoplasmic reticulum calcium ion transport (GO:0070296)2.83727212
117coronary vasculature morphogenesis (GO:0060977)2.83488967
118mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83485664
119striated muscle hypertrophy (GO:0014897)2.81679793
120cornea development in camera-type eye (GO:0061303)2.80559346
121microtubule polymerization or depolymerization (GO:0031109)2.79612895
122regulation of actin filament-based movement (GO:1903115)2.79167758
123potassium ion export (GO:0071435)2.78243520
124ethanol oxidation (GO:0006069)2.75951672
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.75644500
126striated muscle atrophy (GO:0014891)2.75464239
127sperm-egg recognition (GO:0035036)2.75315984
128heart trabecula formation (GO:0060347)2.75159804
129protein hydroxylation (GO:0018126)2.73178012
130multicellular organism reproduction (GO:0032504)2.72893277
131behavioral response to nicotine (GO:0035095)2.72860300
132retinol metabolic process (GO:0042572)2.72625645
133retinal rod cell development (GO:0046548)2.72574432
134intra-S DNA damage checkpoint (GO:0031573)2.72065457
135aldehyde catabolic process (GO:0046185)2.71053293
136G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.70853770
137striated muscle contraction (GO:0006941)2.70645463
138myoblast fusion (GO:0007520)2.70212955
139cell communication involved in cardiac conduction (GO:0086065)2.70151344
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69336536
141cardiac muscle cell action potential (GO:0086001)2.68470162
142electron transport chain (GO:0022900)2.67911804
143syncytium formation by plasma membrane fusion (GO:0000768)2.67348182
144peptidyl-proline hydroxylation (GO:0019511)2.66412412
145rRNA methylation (GO:0031167)2.65848685
146spinal cord motor neuron differentiation (GO:0021522)2.65320056
147positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65185464
148receptor guanylyl cyclase signaling pathway (GO:0007168)2.64045745
149negative regulation of potassium ion transport (GO:0043267)2.63448949
150regulation of cytokine production involved in inflammatory response (GO:1900015)2.62786837
151regulation of tolerance induction (GO:0002643)2.62560863
152regulation of relaxation of muscle (GO:1901077)2.62107741
153endothelial cell chemotaxis (GO:0035767)2.61993221
154protein targeting to ER (GO:0045047)2.60721245
155regulation of interleukin-13 production (GO:0032656)2.59863983
156reactive oxygen species biosynthetic process (GO:1903409)2.59643265
157positive regulation of myotube differentiation (GO:0010831)2.59310605
158translational elongation (GO:0006414)2.58563899
159cardiac muscle tissue morphogenesis (GO:0055008)2.57861159
160focal adhesion assembly (GO:0048041)2.57326872
161cell-substrate adherens junction assembly (GO:0007045)2.57326872
162cotranslational protein targeting to membrane (GO:0006613)2.57205439
163regulation of heart rate by cardiac conduction (GO:0086091)2.56887768
164muscle hypertrophy (GO:0014896)2.56674401
165negative regulation of inclusion body assembly (GO:0090084)2.56247482
166O-glycan processing (GO:0016266)2.56201067
167regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.55947530
168cell-substrate junction assembly (GO:0007044)2.55425014
169regulation of interleukin-12 biosynthetic process (GO:0045075)2.55293375
170regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.54769244
171stress fiber assembly (GO:0043149)2.54573503
172SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53987866
173apoptotic process involved in morphogenesis (GO:0060561)2.53724546
174cardiac muscle cell action potential involved in contraction (GO:0086002)2.53287857
175cell-cell recognition (GO:0009988)2.52316805
176neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.52158055
177syncytium formation (GO:0006949)2.51898327
178reproduction (GO:0000003)2.51767910
179peptidyl-lysine dimethylation (GO:0018027)2.51762191
180regulation of synapse structural plasticity (GO:0051823)2.51584436
181regulation of interleukin-6 biosynthetic process (GO:0045408)2.51196903
182negative regulation of humoral immune response (GO:0002921)2.51052045
183regulation of p38MAPK cascade (GO:1900744)2.50803737
184positive regulation of fatty acid beta-oxidation (GO:0032000)2.50320293
185respiratory electron transport chain (GO:0022904)2.50303294
186establishment of protein localization to endoplasmic reticulum (GO:0072599)2.50250384
187desmosome organization (GO:0002934)2.49115979
188positive thymic T cell selection (GO:0045059)2.47856788
189chromosome condensation (GO:0030261)2.47519879
190positive regulation of fibroblast migration (GO:0010763)2.47347346
191regulation of fatty acid oxidation (GO:0046320)2.46883254
192sperm motility (GO:0030317)2.46659864
193regulation of fatty acid beta-oxidation (GO:0031998)2.46563993
194axonemal dynein complex assembly (GO:0070286)17.4358059
195cilium or flagellum-dependent cell motility (GO:0001539)14.9805636
196cilium movement (GO:0003341)12.9727390
197epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9932150
198epithelial cilium movement (GO:0003351)11.5633570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.61339393
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.27498037
3EZH2_22144423_ChIP-Seq_EOC_Human3.82521509
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.55547893
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54345480
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51372894
7* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47032022
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.35328305
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32585196
10* KDM2B_26808549_Chip-Seq_DND41_Human2.31063638
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.29236979
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.29236979
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.29226087
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26518530
15LXR_22292898_ChIP-Seq_THP-1_Human2.24695038
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20497182
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19639917
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17143349
19TDRD3_21172665_ChIP-Seq_MCF-7_Human2.08463409
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05381093
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01843766
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00938657
23KDM2B_26808549_Chip-Seq_K562_Human2.00696465
24TCF7_22412390_ChIP-Seq_EML_Mouse2.00372522
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96968811
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.96862550
27PHF8_20622854_ChIP-Seq_HELA_Human1.96768857
28MYC_22102868_ChIP-Seq_BL_Human1.96455409
29E2F1_20622854_ChIP-Seq_HELA_Human1.90769944
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87661526
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.84909537
32VDR_21846776_ChIP-Seq_THP-1_Human1.82888454
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82381729
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.80400743
35VDR_22108803_ChIP-Seq_LS180_Human1.79976854
36CTCF_27219007_Chip-Seq_Bcells_Human1.79891472
37YY1_22570637_ChIP-Seq_MALME-3M_Human1.79838542
38CTCF_20526341_ChIP-Seq_ESCs_Human1.77367486
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71518650
40* KDM2B_26808549_Chip-Seq_JURKAT_Human1.71517854
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71052431
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69374869
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69025897
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68513819
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65421259
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.65144194
47* RXR_22158963_ChIP-Seq_LIVER_Mouse1.64616059
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63531643
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63033636
50DROSHA_22980978_ChIP-Seq_HELA_Human1.61973367
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.60921336
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.58437167
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58384780
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.58212539
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57955464
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57912968
57RACK7_27058665_Chip-Seq_MCF-7_Human1.57256362
58ZNF263_19887448_ChIP-Seq_K562_Human1.55670749
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54888430
60* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53043625
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.52710867
62* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50494744
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48413645
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47167372
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.45227016
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43144637
67STAT1_20625510_ChIP-Seq_HELA_Human1.42992989
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42116182
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39758829
70* BCOR_27268052_Chip-Seq_Bcells_Human1.38208722
71XRN2_22483619_ChIP-Seq_HELA_Human1.37073191
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35867276
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35416524
74* TP63_22573176_ChIP-Seq_HFKS_Human1.33438636
75* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33230993
76* ERA_21632823_ChIP-Seq_H3396_Human1.32799082
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.32385618
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32104902
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31423425
80* BCL6_27268052_Chip-Seq_Bcells_Human1.29408010
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28749260
82P300_27268052_Chip-Seq_Bcells_Human1.28492294
83MAF_26560356_Chip-Seq_TH1_Human1.28345580
84SMC4_20622854_ChIP-Seq_HELA_Human1.28100021
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27827971
86UTX_26944678_Chip-Seq_JUKART_Human1.27808372
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.26923643
88MYC_19829295_ChIP-Seq_ESCs_Human1.26871421
89SA1_27219007_Chip-Seq_Bcells_Human1.26578714
90SOX2_21211035_ChIP-Seq_LN229_Human1.26114275
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23734275
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22975150
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22275806
94* EZH2_27294783_Chip-Seq_ESCs_Mouse1.22186570
95MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21813784
96RARB_24833708_ChIP-Seq_LIVER_Mouse1.21611117
97NCOR1_26117541_ChIP-Seq_K562_Human1.21561098
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20501129
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20290288
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19789106
101* P68_20966046_ChIP-Seq_HELA_Human1.18978251
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.18842919
103RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18742863
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18711915
105EWS_26573619_Chip-Seq_HEK293_Human1.18282513
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18012131
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17856985
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17170674
109EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16164849
110TP53_22127205_ChIP-Seq_IMR90_Human1.15905043
111SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15713156
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.13943814
113ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13933475
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13322459
115FOXP1_21924763_ChIP-Seq_HESCs_Human1.13059582
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12944829
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.11951354
118NANOG_20526341_ChIP-Seq_ESCs_Human1.11794624
119TRIM28_21343339_ChIP-Seq_HEK293_Human1.11048125
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.10131073
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10116605
122VDR_24787735_ChIP-Seq_THP-1_Human1.08689158
123* CREB1_26743006_Chip-Seq_LNCaP_Human1.08631981
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08079108
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07699417
126RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06885856
127TAF2_19829295_ChIP-Seq_ESCs_Human1.06868111
128MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06719874
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.06700083
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06508884
131* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06046529
132FLI1_21867929_ChIP-Seq_CD8_Mouse1.04846362
133OCT4_20526341_ChIP-Seq_ESCs_Human1.04806467
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04567010
135* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04242185
136CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03812483
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03748584
138GATA1_19941826_ChIP-Seq_K562_Human1.03598520
139* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02920505
140ERG_20517297_ChIP-Seq_VCAP_Human1.02258717
141P53_21459846_ChIP-Seq_SAOS-2_Human1.01902934
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.00666009
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00062540
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99343149
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99335473
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98826856
147VDR_24763502_ChIP-Seq_THP-1_Human0.98426113
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.97477198
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.97058274
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96485896
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96305026
152NCOR_22424771_ChIP-Seq_293T_Human0.95957588
153GABP_17652178_ChIP-ChIP_JURKAT_Human0.95180929
154* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95046806
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94261114
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93487316
157SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92951066
158GATA3_21867929_ChIP-Seq_CD8_Mouse0.92918970
159MAF_26560356_Chip-Seq_TH2_Human0.92007310
160ATF3_27146783_Chip-Seq_COLON_Human0.91933791
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91839524
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.91763868
163GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91666228
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91170055
165RNF2_27304074_Chip-Seq_ESCs_Mouse0.90794836
166JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89571288
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.88991866
168KLF5_25053715_ChIP-Seq_YYC3_Human0.88912283
169FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87947466
170FOXA1_25329375_ChIP-Seq_VCAP_Human0.87947466
171GATA3_21878914_ChIP-Seq_MCF-7_Human0.87370449
172P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87168897
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86865992
174AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85108937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology7.19582137
2MP0008875_abnormal_xenobiotic_pharmacok5.34530994
3MP0002837_dystrophic_cardiac_calcinosis4.89992984
4MP0003136_yellow_coat_color4.85241799
5MP0000751_myopathy4.65341622
6MP0009379_abnormal_foot_pigmentation4.24842823
7MP0002277_abnormal_respiratory_mucosa4.18963914
8MP0000566_synostosis3.68759621
9MP0004133_heterotaxia3.62502532
10MP0004215_abnormal_myocardial_fiber3.30585096
11MP0004084_abnormal_cardiac_muscle3.17691931
12MP0000750_abnormal_muscle_regeneration3.02713051
13MP0002132_abnormal_respiratory_system2.93627951
14MP0001188_hyperpigmentation2.88353869
15MP0004087_abnormal_muscle_fiber2.70923239
16MP0005330_cardiomyopathy2.64485415
17MP0005410_abnormal_fertilization2.62240245
18MP0003646_muscle_fatigue2.56998864
19MP0000749_muscle_degeneration2.55365713
20MP0001984_abnormal_olfaction2.51126560
21MP0005377_hearing/vestibular/ear_phenot2.47117804
22MP0003878_abnormal_ear_physiology2.47117804
23MP0004233_abnormal_muscle_weight2.45917107
24MP0004036_abnormal_muscle_relaxation2.40814260
25MP0010630_abnormal_cardiac_muscle2.35376355
26MP0004510_myositis2.34147984
27MP0003279_aneurysm2.29229636
28MP0003705_abnormal_hypodermis_morpholog2.26343643
29MP0005623_abnormal_meninges_morphology2.25931452
30MP0005174_abnormal_tail_pigmentation2.24663712
31MP0004019_abnormal_vitamin_homeostasis2.21273995
32MP0005171_absent_coat_pigmentation2.20844197
33MP0008789_abnormal_olfactory_epithelium2.18789786
34MP0002638_abnormal_pupillary_reflex2.17347010
35MP0004130_abnormal_muscle_cell2.17340446
36MP0001986_abnormal_taste_sensitivity2.15249906
37MP0005670_abnormal_white_adipose2.14969324
38MP0003137_abnormal_impulse_conducting2.10192724
39MP0003303_peritoneal_inflammation2.06881928
40MP0002269_muscular_atrophy1.97470515
41MP0005451_abnormal_body_composition1.94177557
42MP0000759_abnormal_skeletal_muscle1.86197028
43MP0010030_abnormal_orbit_morphology1.83148584
44MP0003283_abnormal_digestive_organ1.82209078
45MP0000747_muscle_weakness1.79043001
46MP0002234_abnormal_pharynx_morphology1.74447636
47MP0008961_abnormal_basal_metabolism1.73653763
48MP0002972_abnormal_cardiac_muscle1.73496693
49MP0008438_abnormal_cutaneous_collagen1.71775385
50MP0003566_abnormal_cell_adhesion1.71387115
51MP0002139_abnormal_hepatobiliary_system1.71095067
52MP0002160_abnormal_reproductive_system1.68759392
53MP0002909_abnormal_adrenal_gland1.65860903
54MP0004885_abnormal_endolymph1.65539609
55MP0005187_abnormal_penis_morphology1.65265530
56MP0005666_abnormal_adipose_tissue1.64276877
57MP0001346_abnormal_lacrimal_gland1.62808493
58MP0002106_abnormal_muscle_physiology1.62279528
59MP0000733_abnormal_muscle_development1.55927107
60MP0003828_pulmonary_edema1.54808675
61MP0005375_adipose_tissue_phenotype1.54165356
62MP0005620_abnormal_muscle_contractility1.52583307
63MP0001544_abnormal_cardiovascular_syste1.52310935
64MP0005385_cardiovascular_system_phenoty1.52310935
65MP0002282_abnormal_trachea_morphology1.51578694
66MP0001756_abnormal_urination1.47429970
67MP0000383_abnormal_hair_follicle1.41352341
68MP0004185_abnormal_adipocyte_glucose1.40915249
69MP0009780_abnormal_chondrocyte_physiolo1.39612925
70MP0000003_abnormal_adipose_tissue1.35591469
71MP0004085_abnormal_heartbeat1.34681151
72MP0001502_abnormal_circadian_rhythm1.34216443
73MP0004484_altered_response_of1.32776590
74MP0008775_abnormal_heart_ventricle1.32041021
75MP0003221_abnormal_cardiomyocyte_apopto1.31501716
76MP0004145_abnormal_muscle_electrophysio1.30634651
77MP0001944_abnormal_pancreas_morphology1.28010330
78MP0005369_muscle_phenotype1.27875684
79MP0002735_abnormal_chemical_nociception1.25669217
80MP0003656_abnormal_erythrocyte_physiolo1.21604894
81MP0006138_congestive_heart_failure1.21168689
82MP0003252_abnormal_bile_duct1.20683919
83MP0002127_abnormal_cardiovascular_syste1.20290122
84MP0002249_abnormal_larynx_morphology1.20204130
85MP0000049_abnormal_middle_ear1.19792858
86MP0002928_abnormal_bile_duct1.19762660
87MP0009840_abnormal_foam_cell1.19174074
88MP0009278_abnormal_bone_marrow1.12406111
89MP0000631_abnormal_neuroendocrine_gland1.10751258
90MP0000026_abnormal_inner_ear1.09857510
91MP0003091_abnormal_cell_migration1.09343873
92MP0000266_abnormal_heart_morphology1.07938347
93MP0001968_abnormal_touch/_nociception1.07433110
94MP0005499_abnormal_olfactory_system1.04808359
95MP0005394_taste/olfaction_phenotype1.04808359
96MP0005257_abnormal_intraocular_pressure1.03692507
97MP0001958_emphysema1.03666203
98MP0005365_abnormal_bile_salt1.03283361
99MP0005084_abnormal_gallbladder_morpholo1.01818341
100MP0003300_gastrointestinal_ulcer1.00909945
101MP0000767_abnormal_smooth_muscle0.97295915
102MP0005409_darkened_coat_color0.97138438
103MP0004808_abnormal_hematopoietic_stem0.96845556
104MP0008872_abnormal_physiological_respon0.96208908
105MP0005389_reproductive_system_phenotype0.95187984
106MP0003453_abnormal_keratinocyte_physiol0.94882746
107MP0001293_anophthalmia0.94878618
108MP0001324_abnormal_eye_pigmentation0.93093202
109MP0001905_abnormal_dopamine_level0.92806485
110MP0003385_abnormal_body_wall0.90487188
111MP0000428_abnormal_craniofacial_morphol0.90210898
112MP0010678_abnormal_skin_adnexa0.87203868
113MP0000013_abnormal_adipose_tissue0.85806265
114MP0002938_white_spotting0.83658669
115MP0002128_abnormal_blood_circulation0.83012380
116MP0003938_abnormal_ear_development0.82972251
117MP0005551_abnormal_eye_electrophysiolog0.82020735
118MP0005636_abnormal_mineral_homeostasis0.81608189
119MP0009384_cardiac_valve_regurgitation0.81064172
120MP0009643_abnormal_urine_homeostasis0.80851762
121MP0000534_abnormal_ureter_morphology0.79637440
122MP0008874_decreased_physiological_sensi0.78655053
123MP0003045_fibrosis0.78635056
124MP0003806_abnormal_nucleotide_metabolis0.78452541
125MP0002736_abnormal_nociception_after0.77349477
126MP0005253_abnormal_eye_physiology0.76758983
127MP0009046_muscle_twitch0.73496839
128MP0002168_other_aberrant_phenotype0.71526131
129MP0003890_abnormal_embryonic-extraembry0.71070142
130MP0005220_abnormal_exocrine_pancreas0.70770662
131MP0002136_abnormal_kidney_physiology0.70493833
132MP0003115_abnormal_respiratory_system0.70389923
133MP0001661_extended_life_span0.69862956
134MP0000678_abnormal_parathyroid_gland0.69793117
135MP0001485_abnormal_pinna_reflex0.69740699
136MP0003937_abnormal_limbs/digits/tail_de0.68672635
137MP0001663_abnormal_digestive_system0.68259085
138MP0005360_urolithiasis0.68256995
139MP0009672_abnormal_birth_weight0.67848662
140MP0001270_distended_abdomen0.66965359
141MP0005195_abnormal_posterior_eye0.66816601
142MP0002396_abnormal_hematopoietic_system0.65485927
143MP0002693_abnormal_pancreas_physiology0.64891323
144MP0002116_abnormal_craniofacial_bone0.63538146
145MP0003567_abnormal_fetal_cardiomyocyte0.62702912
146MP0001963_abnormal_hearing_physiology0.61875207
147MP0005391_vision/eye_phenotype0.61810656
148MP0010352_gastrointestinal_tract_polyps0.61308826
149MP0002822_catalepsy0.60894659
150MP0004381_abnormal_hair_follicle0.59834236
151MP0010368_abnormal_lymphatic_system0.58561582
152MP0005023_abnormal_wound_healing0.58487644
153MP0005332_abnormal_amino_acid0.58335328
154MP0003941_abnormal_skin_development0.57461244
155MP0005646_abnormal_pituitary_gland0.57335281
156MP0005387_immune_system_phenotype0.56886249
157MP0001790_abnormal_immune_system0.56886249
158MP0000538_abnormal_urinary_bladder0.56325720
159MP0001765_abnormal_ion_homeostasis0.56247762
160MP0002971_abnormal_brown_adipose0.56169469
161MP0001784_abnormal_fluid_regulation0.56131073
162MP0005381_digestive/alimentary_phenotyp0.56109759
163MP0002184_abnormal_innervation0.56006031
164MP0002998_abnormal_bone_remodeling0.55977766
165MP0002734_abnormal_mechanical_nocicepti0.55833029
166MP0002933_joint_inflammation0.55593892
167MP0005395_other_phenotype0.54721682
168MP0005423_abnormal_somatic_nervous0.54572552
169MP0003119_abnormal_digestive_system0.54314436
170MP0002111_abnormal_tail_morphology0.53863320
171MP0008770_decreased_survivor_rate0.53827410
172MP0001299_abnormal_eye_distance/0.53367533
173MP0005083_abnormal_biliary_tract0.53110417
174MP0002925_abnormal_cardiovascular_devel0.52506725
175MP0002108_abnormal_muscle_morphology0.52176133
176MP0000470_abnormal_stomach_morphology0.50650046
177MP0003984_embryonic_growth_retardation0.50145892
178MP0003698_abnormal_male_reproductive0.49975127
179MP0002088_abnormal_embryonic_growth/wei0.49965178
180MP0001879_abnormal_lymphatic_vessel0.49723431
181MP0004043_abnormal_pH_regulation0.49655747
182MP0003942_abnormal_urinary_system0.49189400
183MP0004197_abnormal_fetal_growth/weight/0.48991034
184MP0004742_abnormal_vestibular_system0.48959677
185MP0005165_increased_susceptibility_to0.48839230

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.87743239
2Abnormal ciliary motility (HP:0012262)9.85257504
3Rhinitis (HP:0012384)9.00231716
4Chronic bronchitis (HP:0004469)6.65844289
5Bronchiectasis (HP:0002110)6.46703789
6Nasal polyposis (HP:0100582)6.06579186
7Sudden death (HP:0001699)5.25794471
8Abnormality of the nasal mucosa (HP:0000433)5.12710036
9Muscle fiber splitting (HP:0003555)4.56729563
10Ventricular tachycardia (HP:0004756)4.23574602
11Chronic sinusitis (HP:0011109)3.88103902
12Bundle branch block (HP:0011710)3.84894417
13Hyporeflexia of lower limbs (HP:0002600)3.84562947
14Increased connective tissue (HP:0009025)3.84440656
15Atrial fibrillation (HP:0005110)3.78987382
16Recurrent sinusitis (HP:0011108)3.75509054
17Infertility (HP:0000789)3.64873634
18Pancreatic fibrosis (HP:0100732)3.57311209
19Prolonged QT interval (HP:0001657)3.52364638
20True hermaphroditism (HP:0010459)3.49780995
21Male infertility (HP:0003251)3.49075252
22Distal lower limb amyotrophy (HP:0008944)3.46955850
23Abnormality of midbrain morphology (HP:0002418)3.46670812
24Molar tooth sign on MRI (HP:0002419)3.46670812
25Bronchitis (HP:0012387)3.45611030
26Primary atrial arrhythmia (HP:0001692)3.44299984
27Exercise-induced myalgia (HP:0003738)3.35202896
28Nephronophthisis (HP:0000090)3.34578242
29Syncope (HP:0001279)3.31979677
30Supraventricular tachycardia (HP:0004755)3.23069213
31Abnormality of the calf musculature (HP:0001430)3.19690965
32Occipital encephalocele (HP:0002085)3.18314378
33Supraventricular arrhythmia (HP:0005115)3.16814826
34Atrioventricular block (HP:0001678)3.15516590
35Difficulty climbing stairs (HP:0003551)3.14427379
36EMG: myopathic abnormalities (HP:0003458)3.12724769
37Ventricular fibrillation (HP:0001663)3.09927003
38Heart block (HP:0012722)3.08180681
39Pancreatic cysts (HP:0001737)3.05904746
40Abnormal atrioventricular conduction (HP:0005150)3.05033267
41Recurrent otitis media (HP:0000403)2.98494673
42Upper limb amyotrophy (HP:0009129)2.98449817
43Distal upper limb amyotrophy (HP:0007149)2.98449817
44Hyperacusis (HP:0010780)2.95586964
45Lipoatrophy (HP:0100578)2.92979673
46Cerebral aneurysm (HP:0004944)2.90896211
47Lower limb amyotrophy (HP:0007210)2.86450186
48Chronic otitis media (HP:0000389)2.84105851
49Exercise-induced muscle cramps (HP:0003710)2.83771781
50Calf muscle hypertrophy (HP:0008981)2.77471929
51Chronic hepatic failure (HP:0100626)2.75521115
52Cystic liver disease (HP:0006706)2.75246406
53EMG: neuropathic changes (HP:0003445)2.74073578
54Right ventricular cardiomyopathy (HP:0011663)2.71218088
55Ventricular arrhythmia (HP:0004308)2.66170949
56Myoglobinuria (HP:0002913)2.65769002
57Broad metatarsal (HP:0001783)2.65025905
58Premature rupture of membranes (HP:0001788)2.60371401
59Hypoplastic ischia (HP:0003175)2.58554210
60Abnormality of the renal medulla (HP:0100957)2.56313424
61Difficulty running (HP:0009046)2.53164435
62Asymmetric septal hypertrophy (HP:0001670)2.51250895
63Mildly elevated creatine phosphokinase (HP:0008180)2.51103767
64Insomnia (HP:0100785)2.47112799
65Muscle hypertrophy of the lower extremities (HP:0008968)2.43595595
66Atelectasis (HP:0100750)2.41398610
67Hand muscle atrophy (HP:0009130)2.41353171
68Vertebral arch anomaly (HP:0008438)2.39032989
69Protrusio acetabuli (HP:0003179)2.36495814
70Hyperactive renin-angiotensin system (HP:0000841)2.35123750
71Scapular winging (HP:0003691)2.34238223
72Limited hip movement (HP:0008800)2.33138845
73Ulnar bowing (HP:0003031)2.30228885
74Subaortic stenosis (HP:0001682)2.27953920
75Abnormality of the left ventricular outflow tract (HP:0011103)2.27953920
76Flat cornea (HP:0007720)2.25877795
77Type 1 muscle fiber predominance (HP:0003803)2.25549677
78Congenital hepatic fibrosis (HP:0002612)2.24640630
79Abnormality of the ischium (HP:0003174)2.24273286
80Limited elbow extension (HP:0001377)2.23272208
81Sudden cardiac death (HP:0001645)2.20855072
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.18112765
83Shallow orbits (HP:0000586)2.17971061
84Decreased circulating renin level (HP:0003351)2.17666954
85Anencephaly (HP:0002323)2.16393284
86Increased variability in muscle fiber diameter (HP:0003557)2.15899239
87Rib fusion (HP:0000902)2.13993731
88Dilated cardiomyopathy (HP:0001644)2.11036004
89Postaxial foot polydactyly (HP:0001830)2.09471437
90Bladder diverticulum (HP:0000015)2.08649340
91Male pseudohermaphroditism (HP:0000037)2.06449138
92Supranuclear gaze palsy (HP:0000605)2.04057028
93Potter facies (HP:0002009)2.03932954
94Facial shape deformation (HP:0011334)2.03932954
95Hip contracture (HP:0003273)2.02563790
96Overriding aorta (HP:0002623)2.01410885
97Ketoacidosis (HP:0001993)2.00144847
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8017153
99Abnormal respiratory epithelium morphology (HP:0012253)10.4173862
100Abnormal respiratory motile cilium morphology (HP:0005938)10.4173862
101Abnormal EKG (HP:0003115)1.98895650
102Dynein arm defect of respiratory motile cilia (HP:0012255)1.98330279
103Absent/shortened dynein arms (HP:0200106)1.98330279
104Colitis (HP:0002583)1.98117649
105Elfin facies (HP:0004428)1.97911824
106Dysmetric saccades (HP:0000641)1.96359416
107Furrowed tongue (HP:0000221)1.95937118
108Myocardial infarction (HP:0001658)1.93907406
109Medial flaring of the eyebrow (HP:0010747)1.93004907
110Tubular atrophy (HP:0000092)1.92514807
111Abnormal drinking behavior (HP:0030082)1.92266442
112Polydipsia (HP:0001959)1.92266442
113Renovascular hypertension (HP:0100817)1.92024498
114Rhabdomyolysis (HP:0003201)1.91993677
115Abnormality of the tricuspid valve (HP:0001702)1.91398322
116Pelvic girdle muscle weakness (HP:0003749)1.89701486
117Fragile skin (HP:0001030)1.89476619
118Renal duplication (HP:0000075)1.87958843
119Abnormality of skeletal muscle fiber size (HP:0012084)1.86981521
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.86685867
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.86019164
122Increased density of long bones (HP:0006392)1.85894884
123Double outlet right ventricle (HP:0001719)1.84984151
124Congenital malformation of the right heart (HP:0011723)1.84984151
125Mask-like facies (HP:0000298)1.82900564
126Sclerocornea (HP:0000647)1.82574712
127Long toe (HP:0010511)1.82524515
128Increased hepatocellular lipid droplets (HP:0006565)1.82217182
129Testicular atrophy (HP:0000029)1.80695104
130Limb-girdle muscle weakness (HP:0003325)1.80379439
131Nephropathy (HP:0000112)1.79002140
132Reticulocytosis (HP:0001923)1.78609949
133Osteomalacia (HP:0002749)1.78552126
134Rapidly progressive (HP:0003678)1.78524743
135Palpitations (HP:0001962)1.77574357
136Upper limb muscle weakness (HP:0003484)1.75172750
137Ankle contracture (HP:0006466)1.74566280
138Aplasia of the musculature (HP:0100854)1.74182638
139Inflammation of the large intestine (HP:0002037)1.73909236
140Renal Fanconi syndrome (HP:0001994)1.73855967
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73845571
142Global brain atrophy (HP:0002283)1.73808123
143Truncus arteriosus (HP:0001660)1.73780244
144Acute lymphatic leukemia (HP:0006721)1.73656199
145Abnormality of lateral ventricle (HP:0030047)1.73279948
146Increased nuchal translucency (HP:0010880)1.72514602
147Decreased central vision (HP:0007663)1.72496008
148Xanthomatosis (HP:0000991)1.70968630
149Congenital, generalized hypertrichosis (HP:0004540)1.70813042
150Lipid accumulation in hepatocytes (HP:0006561)1.65215171
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63351290
152Bony spicule pigmentary retinopathy (HP:0007737)1.63013351
153Oculomotor apraxia (HP:0000657)1.60460992
154Congenital primary aphakia (HP:0007707)1.58962145
155Abnormality of renin-angiotensin system (HP:0000847)1.55259904
156Gait imbalance (HP:0002141)1.54377015
157Popliteal pterygium (HP:0009756)1.50764978
158Renal salt wasting (HP:0000127)1.50571571
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.49524951
160Asplenia (HP:0001746)1.48078399
161Abnormal rod and cone electroretinograms (HP:0008323)1.43840531
162Tubulointerstitial nephritis (HP:0001970)1.43761264
163Postaxial hand polydactyly (HP:0001162)1.42540352
164Abnormality of renal resorption (HP:0011038)1.42018017
165Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.41792662
166Vaginal fistula (HP:0004320)1.39645123
167Abnormality of chloride homeostasis (HP:0011422)1.37954753
168Congenital stationary night blindness (HP:0007642)1.37727325
169Exertional dyspnea (HP:0002875)1.37523860
170Rectal fistula (HP:0100590)1.36570779
171Rectovaginal fistula (HP:0000143)1.36570779
172Stage 5 chronic kidney disease (HP:0003774)1.35921289
173Rickets (HP:0002748)1.34566737
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34362831
175Bell-shaped thorax (HP:0001591)1.33893133
176Polyuria (HP:0000103)1.33809969
177Nephrogenic diabetes insipidus (HP:0009806)1.33516767
178Fetal akinesia sequence (HP:0001989)1.32808593
179Abnormal number of erythroid precursors (HP:0012131)1.29775363
180Hypoalbuminemia (HP:0003073)1.29524089
181Abnormal albumin level (HP:0012116)1.29524089
182Coronal craniosynostosis (HP:0004440)1.28089733
183Hyperkalemia (HP:0002153)1.27522581
184Preaxial hand polydactyly (HP:0001177)1.26285384
185Recurrent bronchitis (HP:0002837)1.25450665
186Retinitis pigmentosa (HP:0000510)1.23153148
187Abnormality of the renal cortex (HP:0011035)1.23020691
188Attenuation of retinal blood vessels (HP:0007843)1.22468590
189Short femoral neck (HP:0100864)1.21604886
190Methylmalonic acidemia (HP:0002912)1.21582687
191Maternal diabetes (HP:0009800)1.21270284
192Dyschromatopsia (HP:0007641)1.20172654
193Renal tubular dysfunction (HP:0000124)1.19421882
194Genital tract atresia (HP:0001827)1.19046992
195Vaginal atresia (HP:0000148)1.17964195
196Hyperaldosteronism (HP:0000859)1.16867448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK24.48438459
2TTN4.34989054
3TLK14.22861103
4STK164.22392775
5TRIB34.06813201
6MST43.74198403
7PNCK3.20256414
8NME12.76364495
9EEF2K2.67453039
10SIK12.63864754
11DMPK2.54456494
12EPHA22.50102823
13PKN22.37458243
14MAP3K102.25032967
15MAPK151.95239778
16ICK1.89355444
17PASK1.87530768
18OBSCN1.74408223
19PDK31.68623930
20PDK41.68623930
21PHKG21.54186237
22PHKG11.54186237
23ERN11.53964606
24ADRBK21.51791190
25BLK1.50828348
26LMTK21.50321431
27MAP4K11.49284119
28RIPK11.48741236
29PDGFRA1.47301768
30ILK1.43370744
31IRAK11.40106580
32ZAP701.34808097
33WNK11.31500240
34CAMK1G1.30876023
35PTK61.29715066
36MAPKAPK31.28274764
37CDK121.26659393
38ALK1.23726557
39BRD41.20712416
40BMPR1B1.20706811
41TTK1.20124595
42BMX1.19105836
43STK241.16777496
44NEK21.16681834
45MST1R1.14607873
46NLK1.11016169
47FGFR21.09244796
48TRPM71.08129572
49PRKD11.07593595
50MARK21.06581716
51TNIK1.05873662
52BUB11.04494826
53MARK31.04129076
54TAOK11.03244150
55MTOR1.03113529
56WNK41.02931476
57EPHB11.02815385
58PAK21.01293366
59STK380.99471922
60GRK10.98669523
61TNK20.96997145
62MAP3K20.95991647
63PRKCH0.91926023
64GRK60.90308620
65PTK2B0.90099657
66TESK10.89472426
67MAP2K30.89279368
68TSSK60.87796864
69MAP3K30.87631738
70MAP2K60.83149917
71STK110.81900629
72CDK40.81896375
73MAP3K70.80769543
74PKN10.80044833
75ROCK20.79433657
76SMG10.78711877
77MAP3K110.77438018
78VRK20.76316704
79MUSK0.75929775
80PRKD30.73709742
81CAMK1D0.71816472
82WEE10.71713927
83STK40.68926258
84ROCK10.65539107
85PDGFRB0.64737454
86CSK0.64691402
87JAK30.64559813
88ADRBK10.64003982
89FGFR40.63459025
90CASK0.62965776
91VRK10.62172403
92PRKAA10.60748551
93LRRK20.59210613
94PIK3CA0.58750115
95MAPKAPK50.57705766
96JAK10.57154511
97CAMK2D0.56143899
98DYRK1B0.55980912
99HCK0.55539016
100PDK20.55151198
101FGFR30.54819726
102CHUK0.53075806
103PDPK10.53046966
104INSRR0.52725787
105PTK20.52394351
106PRKAA20.50069669
107SGK30.49473452
108STK100.49131225
109PRKCI0.48684346
110TGFBR10.48606711
111MET0.48534105
112CDK60.47101496
113CDC42BPA0.45932325
114FRK0.45507989
115TBK10.45250933
116PDK10.44737459
117FGFR10.43748240
118EPHA30.43474563
119PLK10.43337174
120MAP3K80.42724532
121EPHB20.41976941
122STK30.41824561
123CSNK1G10.41734589
124HIPK20.41684338
125ERBB20.41335229
126TYRO30.41164712
127RPS6KA40.40589335
128BCKDK0.40428736
129TAOK30.39749718
130AKT20.39530498
131IKBKB0.39493237
132RPS6KA20.39320960
133CAMKK10.38591004
134MAP2K40.37811077
135CSNK1E0.36181222
136OXSR10.36056024
137CHEK20.35809903
138PRKCD0.35506711
139DYRK20.35351744
140ZAK0.35174414
141RET0.34612085
142PRKD20.34144791
143STK38L0.33652664
144NUAK10.33477814
145MAPK80.33160883
146RPS6KA10.32473217
147DDR20.32098773
148CDK30.31411972
149PRKCQ0.30856866
150AURKA0.30590601
151PRKACA0.30018818
152SGK10.29494073
153MAP2K20.28653269
154PRKCG0.27632593
155DYRK30.27225413
156MAP3K120.23862126
157NEK90.23752125
158IRAK20.23675483
159PRKG10.22276554
160RPS6KA60.19248105
161MATK0.17813308
162STK390.16842260
163CSNK1A10.15318418
164NTRK30.15127139
165RPS6KA50.14890684
166LYN0.14624336
167IKBKE0.13504425
168PRKCA0.13196503

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.94307074
2Huntingtons disease_Homo sapiens_hsa050163.60797288
3Ribosome_Homo sapiens_hsa030103.49920105
4Chemical carcinogenesis_Homo sapiens_hsa052043.32004814
5Oxidative phosphorylation_Homo sapiens_hsa001903.30260289
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.08270216
7Dilated cardiomyopathy_Homo sapiens_hsa054143.04715723
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01508649
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.94426676
10Lysine degradation_Homo sapiens_hsa003102.77369677
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.71102453
12Histidine metabolism_Homo sapiens_hsa003402.42984683
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.38721225
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.31222733
15Parkinsons disease_Homo sapiens_hsa050122.29511263
16Collecting duct acid secretion_Homo sapiens_hsa049662.25832319
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24717830
18Fatty acid degradation_Homo sapiens_hsa000712.03424494
19Cardiac muscle contraction_Homo sapiens_hsa042601.89794174
20Insulin resistance_Homo sapiens_hsa049311.84896043
21Glutathione metabolism_Homo sapiens_hsa004801.82835455
22Viral myocarditis_Homo sapiens_hsa054161.82631366
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76597518
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74813959
25Sphingolipid metabolism_Homo sapiens_hsa006001.72743869
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72656603
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72088443
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71995455
29Alzheimers disease_Homo sapiens_hsa050101.71281838
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70175566
31Glucagon signaling pathway_Homo sapiens_hsa049221.68163938
32Type II diabetes mellitus_Homo sapiens_hsa049301.66786209
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65783158
34Linoleic acid metabolism_Homo sapiens_hsa005911.64765181
35Nitrogen metabolism_Homo sapiens_hsa009101.62902770
36Basal cell carcinoma_Homo sapiens_hsa052171.62889231
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62486051
38Hedgehog signaling pathway_Homo sapiens_hsa043401.59725103
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.55157170
40Vitamin digestion and absorption_Homo sapiens_hsa049771.51956117
41Butanoate metabolism_Homo sapiens_hsa006501.48834124
42PPAR signaling pathway_Homo sapiens_hsa033201.48243265
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47589917
44Protein export_Homo sapiens_hsa030601.46306305
45Caffeine metabolism_Homo sapiens_hsa002321.41305187
46Retinol metabolism_Homo sapiens_hsa008301.41148085
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39792998
48Sulfur relay system_Homo sapiens_hsa041221.36525441
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35888480
50AMPK signaling pathway_Homo sapiens_hsa041521.35234665
51Carbon metabolism_Homo sapiens_hsa012001.34615930
52Fatty acid metabolism_Homo sapiens_hsa012121.32813349
53RNA polymerase_Homo sapiens_hsa030201.31812873
54Tryptophan metabolism_Homo sapiens_hsa003801.31360540
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29893166
56Propanoate metabolism_Homo sapiens_hsa006401.29410373
57Focal adhesion_Homo sapiens_hsa045101.18029754
58Bile secretion_Homo sapiens_hsa049761.16536847
59Arginine biosynthesis_Homo sapiens_hsa002201.13688280
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12802331
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.11850192
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10957003
63ECM-receptor interaction_Homo sapiens_hsa045121.05832815
64Proteoglycans in cancer_Homo sapiens_hsa052051.05684936
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05041270
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99454676
67* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98295427
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98113422
69Insulin secretion_Homo sapiens_hsa049110.95397895
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94855418
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94690663
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.93725271
73Basal transcription factors_Homo sapiens_hsa030220.93616588
74Phototransduction_Homo sapiens_hsa047440.93594077
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93590562
76Phenylalanine metabolism_Homo sapiens_hsa003600.91031912
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90673939
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87892602
79Biosynthesis of amino acids_Homo sapiens_hsa012300.87348304
80Small cell lung cancer_Homo sapiens_hsa052220.84272493
81Renin secretion_Homo sapiens_hsa049240.83245430
82* Cocaine addiction_Homo sapiens_hsa050300.81196109
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80353325
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80143958
85Peroxisome_Homo sapiens_hsa041460.79679106
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78428487
87Insulin signaling pathway_Homo sapiens_hsa049100.78006242
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.77888356
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.77202128
90Adherens junction_Homo sapiens_hsa045200.76941148
91mTOR signaling pathway_Homo sapiens_hsa041500.75344136
92Chronic myeloid leukemia_Homo sapiens_hsa052200.75314861
93MicroRNAs in cancer_Homo sapiens_hsa052060.75062959
94ABC transporters_Homo sapiens_hsa020100.74845967
95Pyruvate metabolism_Homo sapiens_hsa006200.73532413
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71605169
97Starch and sucrose metabolism_Homo sapiens_hsa005000.71504162
98B cell receptor signaling pathway_Homo sapiens_hsa046620.71257414
99Fatty acid biosynthesis_Homo sapiens_hsa000610.68130046
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.67698359
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67612818
102Amoebiasis_Homo sapiens_hsa051460.67196398
103Sulfur metabolism_Homo sapiens_hsa009200.66877557
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65445594
105Arginine and proline metabolism_Homo sapiens_hsa003300.64937954
106Osteoclast differentiation_Homo sapiens_hsa043800.64605610
107Homologous recombination_Homo sapiens_hsa034400.64325491
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64163592
109Hippo signaling pathway_Homo sapiens_hsa043900.63850412
110Notch signaling pathway_Homo sapiens_hsa043300.62735056
111Nucleotide excision repair_Homo sapiens_hsa034200.61306208
112Oxytocin signaling pathway_Homo sapiens_hsa049210.60563723
113beta-Alanine metabolism_Homo sapiens_hsa004100.59143156
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.57845216
115Metabolic pathways_Homo sapiens_hsa011000.57165777
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56979581
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56552143
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.56384062
119Purine metabolism_Homo sapiens_hsa002300.56346412
120Arachidonic acid metabolism_Homo sapiens_hsa005900.54950558
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54468495
122Folate biosynthesis_Homo sapiens_hsa007900.54226855
123Selenocompound metabolism_Homo sapiens_hsa004500.53200906
124Dorso-ventral axis formation_Homo sapiens_hsa043200.52557770
125Tyrosine metabolism_Homo sapiens_hsa003500.51991801
126TGF-beta signaling pathway_Homo sapiens_hsa043500.50284820
127* cAMP signaling pathway_Homo sapiens_hsa040240.50190029
128MAPK signaling pathway_Homo sapiens_hsa040100.49654926
129* Amphetamine addiction_Homo sapiens_hsa050310.48904188
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48311659
131Calcium signaling pathway_Homo sapiens_hsa040200.47686482
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47560944
133Complement and coagulation cascades_Homo sapiens_hsa046100.47261603
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47239241
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.47017336
136Type I diabetes mellitus_Homo sapiens_hsa049400.46326768
137Axon guidance_Homo sapiens_hsa043600.45718031
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45677411
139Estrogen signaling pathway_Homo sapiens_hsa049150.44880593
140Melanogenesis_Homo sapiens_hsa049160.44294045
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44257521
142Lysosome_Homo sapiens_hsa041420.43884191
143FoxO signaling pathway_Homo sapiens_hsa040680.43735193
144Gastric acid secretion_Homo sapiens_hsa049710.43668247
145Platelet activation_Homo sapiens_hsa046110.42092080
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.42021654
147Salmonella infection_Homo sapiens_hsa051320.41816929
148Tight junction_Homo sapiens_hsa045300.41796264
149Hematopoietic cell lineage_Homo sapiens_hsa046400.41756950
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.41661266
151T cell receptor signaling pathway_Homo sapiens_hsa046600.41006631
152Rheumatoid arthritis_Homo sapiens_hsa053230.38511825
153Primary immunodeficiency_Homo sapiens_hsa053400.38343194
154Rap1 signaling pathway_Homo sapiens_hsa040150.37842706
155Renal cell carcinoma_Homo sapiens_hsa052110.37064754
156Taste transduction_Homo sapiens_hsa047420.37037373
157HTLV-I infection_Homo sapiens_hsa051660.36936831
158Asthma_Homo sapiens_hsa053100.36210740
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35433160
160Glioma_Homo sapiens_hsa052140.35039551
161Circadian rhythm_Homo sapiens_hsa047100.34840578
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34299698
163Regulation of autophagy_Homo sapiens_hsa041400.32062645
164Pyrimidine metabolism_Homo sapiens_hsa002400.30968793
165RNA degradation_Homo sapiens_hsa030180.30853290
166Ovarian steroidogenesis_Homo sapiens_hsa049130.30176859
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.29597604
168Wnt signaling pathway_Homo sapiens_hsa043100.29538467
169Mineral absorption_Homo sapiens_hsa049780.29098556
170Glycerolipid metabolism_Homo sapiens_hsa005610.28834956
171Spliceosome_Homo sapiens_hsa030400.28805754
172Fanconi anemia pathway_Homo sapiens_hsa034600.27540171
173Salivary secretion_Homo sapiens_hsa049700.25867858
174Fructose and mannose metabolism_Homo sapiens_hsa000510.23562290
175Allograft rejection_Homo sapiens_hsa053300.22682831
176* Nicotine addiction_Homo sapiens_hsa050330.20161642
177Jak-STAT signaling pathway_Homo sapiens_hsa046300.16347668
178Ether lipid metabolism_Homo sapiens_hsa005650.14549711
179Serotonergic synapse_Homo sapiens_hsa047260.14337042
180Olfactory transduction_Homo sapiens_hsa047400.14156896

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