GRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucose 6-phosphate metabolic process (GO:0051156)5.92443085
2neuron cell-cell adhesion (GO:0007158)5.30668663
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.11984988
4vocalization behavior (GO:0071625)5.09642170
5synaptic vesicle exocytosis (GO:0016079)4.85039976
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56422020
7protein localization to synapse (GO:0035418)4.43729479
8chaperone-mediated protein transport (GO:0072321)4.36840514
9layer formation in cerebral cortex (GO:0021819)4.33422097
10epithelial cilium movement (GO:0003351)4.32889149
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25063258
12regulation of synaptic vesicle exocytosis (GO:2000300)4.21590473
13cell migration in hindbrain (GO:0021535)4.13117951
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05352189
15positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.00241769
16establishment of mitochondrion localization (GO:0051654)3.98473291
17positive regulation of synapse maturation (GO:0090129)3.92419243
18cerebral cortex radially oriented cell migration (GO:0021799)3.89730451
19response to pheromone (GO:0019236)3.87559805
20positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.87105077
21acrosome reaction (GO:0007340)3.85314107
22glutamate secretion (GO:0014047)3.85089382
23retinal ganglion cell axon guidance (GO:0031290)3.83764738
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.81819779
25regulation of glutamate receptor signaling pathway (GO:1900449)3.77721689
26regulation of synaptic vesicle transport (GO:1902803)3.72635339
27presynaptic membrane assembly (GO:0097105)3.71261825
28regulation of penile erection (GO:0060405)3.69763236
29postsynaptic membrane organization (GO:0001941)3.69567446
30neuron recognition (GO:0008038)3.63752309
31neurotransmitter secretion (GO:0007269)3.57195368
32pyrimidine nucleobase catabolic process (GO:0006208)3.55986099
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55642338
34negative regulation of norepinephrine secretion (GO:0010700)3.54648693
35exploration behavior (GO:0035640)3.52914351
36cilium movement (GO:0003341)3.52768427
37regulation of synapse maturation (GO:0090128)3.46647376
38synaptic transmission, glutamatergic (GO:0035249)3.43760772
39mitochondrion transport along microtubule (GO:0047497)3.41037099
40establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41037099
41locomotory exploration behavior (GO:0035641)3.39667826
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.38435526
43substrate-independent telencephalic tangential migration (GO:0021826)3.38019634
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.38019634
45synaptic vesicle maturation (GO:0016188)3.37031493
46glutamate receptor signaling pathway (GO:0007215)3.34389666
47presynaptic membrane organization (GO:0097090)3.33940236
48startle response (GO:0001964)3.33047043
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30094357
50membrane depolarization during action potential (GO:0086010)3.27497701
51negative regulation of dendrite morphogenesis (GO:0050774)3.25623379
52negative regulation of microtubule polymerization (GO:0031115)3.24255809
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22796287
54regulation of neuronal synaptic plasticity (GO:0048168)3.22770539
55calcium ion-dependent exocytosis (GO:0017156)3.22270058
56neuronal action potential propagation (GO:0019227)3.21033022
57synapse assembly (GO:0007416)3.19640025
58dendrite morphogenesis (GO:0048813)3.17797707
59central nervous system neuron axonogenesis (GO:0021955)3.17362688
60regulation of inositol phosphate biosynthetic process (GO:0010919)3.16113020
61proline transport (GO:0015824)3.15741131
62neuron-neuron synaptic transmission (GO:0007270)3.14805172
63neurotransmitter-gated ion channel clustering (GO:0072578)3.14243413
64behavioral response to nicotine (GO:0035095)3.13198231
65spinal cord development (GO:0021510)3.13071177
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.10098147
67axon extension involved in axon guidance (GO:0048846)3.10098147
68axonal fasciculation (GO:0007413)3.10004215
69innervation (GO:0060384)3.09965074
70positive regulation of synapse assembly (GO:0051965)3.09581573
71regulation of synapse structural plasticity (GO:0051823)3.08115237
72gamma-aminobutyric acid transport (GO:0015812)3.07380834
73negative regulation of catecholamine secretion (GO:0033604)3.06460242
74negative regulation of axon guidance (GO:1902668)3.04753713
75central nervous system projection neuron axonogenesis (GO:0021952)3.03852952
76negative regulation of translation, ncRNA-mediated (GO:0040033)3.03740426
77regulation of translation, ncRNA-mediated (GO:0045974)3.03740426
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03740426
79auditory behavior (GO:0031223)3.03681740
80negative regulation of dendrite development (GO:2000171)3.03337999
81head development (GO:0060322)3.03015483
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99881535
83neuronal ion channel clustering (GO:0045161)2.99682755
84synaptic vesicle endocytosis (GO:0048488)2.99669616
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97674692
86mechanosensory behavior (GO:0007638)2.97512033
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96939349
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.92315719
89axon extension (GO:0048675)2.91865048
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90723803
91neurotransmitter transport (GO:0006836)2.90637630
92establishment of nucleus localization (GO:0040023)2.90555300
93cerebellar Purkinje cell differentiation (GO:0021702)2.90148262
94somite development (GO:0061053)2.88492105
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.88439041
96prepulse inhibition (GO:0060134)2.88046241
97detection of calcium ion (GO:0005513)2.87180501
98atrial cardiac muscle cell action potential (GO:0086014)2.86490289
99transmission of nerve impulse (GO:0019226)2.86329811
100neural tube formation (GO:0001841)2.85838393
101synaptic vesicle docking involved in exocytosis (GO:0016081)2.84888092
102calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84786766
103dendritic spine morphogenesis (GO:0060997)2.83504680
104forebrain neuron differentiation (GO:0021879)2.82537399
105hippocampus development (GO:0021766)2.81835113
106olfactory bulb development (GO:0021772)2.81377335
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79978564
108sperm motility (GO:0030317)2.79933829
109regulation of vesicle fusion (GO:0031338)2.78966027
110learning (GO:0007612)2.78606065
111regulation of neurotransmitter secretion (GO:0046928)2.77391131
112regulation of synaptic transmission, GABAergic (GO:0032228)2.73667750
113positive regulation of membrane potential (GO:0045838)2.72784951
114sperm capacitation (GO:0048240)2.71181410
115ganglion development (GO:0061548)2.70917338
116membrane depolarization (GO:0051899)2.70172112
117nucleobase catabolic process (GO:0046113)2.69804362
118neurofilament cytoskeleton organization (GO:0060052)2.69322458
119regulation of postsynaptic membrane potential (GO:0060078)2.68173373
120protein polyglutamylation (GO:0018095)2.67720491
121adenosine receptor signaling pathway (GO:0001973)2.67718137
122sympathetic nervous system development (GO:0048485)2.67549590
123cellular potassium ion homeostasis (GO:0030007)2.67479589
124hindbrain development (GO:0030902)2.66548738
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66181730
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.65868746
127lateral sprouting from an epithelium (GO:0060601)2.64751677
128regulation of axon guidance (GO:1902667)2.63229629
129regulation of synapse assembly (GO:0051963)2.63073515
130limb bud formation (GO:0060174)2.62397823
131regulation of dendritic spine morphogenesis (GO:0061001)2.61885855
132kidney morphogenesis (GO:0060993)2.60473201
133positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60084638
134negative regulation of neurotransmitter transport (GO:0051589)2.59489497
135otic vesicle formation (GO:0030916)2.58815127
136cerebral cortex cell migration (GO:0021795)2.58737511
137negative regulation of neurotransmitter secretion (GO:0046929)2.57385781
138neuron migration (GO:0001764)2.57343703
139axonogenesis (GO:0007409)2.56254823
140negative chemotaxis (GO:0050919)2.55760468
141cell proliferation in forebrain (GO:0021846)2.54472655
142dendrite development (GO:0016358)2.54129357
143retina layer formation (GO:0010842)2.53833497
144regulation of development, heterochronic (GO:0040034)2.52484376
145positive regulation of amino acid transport (GO:0051957)2.52287146
146adult walking behavior (GO:0007628)2.51541600
147negative regulation of axon extension (GO:0030517)2.51291076
148negative regulation of astrocyte differentiation (GO:0048712)2.48972640
149neuron projection extension (GO:1990138)2.48235075
150regulation of cilium movement (GO:0003352)2.47948757
151microtubule anchoring (GO:0034453)2.47874952
152negative regulation of axon extension involved in axon guidance (GO:0048843)2.47416016
153cochlea development (GO:0090102)2.47216639
154nonmotile primary cilium assembly (GO:0035058)2.46042766
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45193349
156synapse organization (GO:0050808)2.41613674
157response to auditory stimulus (GO:0010996)2.40432894
158homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.39541534
159regulation of feeding behavior (GO:0060259)2.39089707
160regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.38444444
161regulation of timing of cell differentiation (GO:0048505)2.38361028
162ephrin receptor signaling pathway (GO:0048013)2.37399912
163lung-associated mesenchyme development (GO:0060484)2.34903633
164negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.32645365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29068483
2GBX2_23144817_ChIP-Seq_PC3_Human3.42113964
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.73639820
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68114156
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.65722415
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62745985
7TAF15_26573619_Chip-Seq_HEK293_Human2.59061109
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54691277
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.54416381
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41450467
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37124290
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31296054
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31296054
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.26351439
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24273844
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21039574
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.19549920
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18703584
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18086329
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17110596
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14071167
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.09945813
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08829803
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07811931
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05833846
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04966665
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03087150
28* EWS_26573619_Chip-Seq_HEK293_Human2.01272824
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00778416
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97762061
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.97259110
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96328130
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93648069
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90725965
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84945881
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75682743
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.75091957
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74560660
39RNF2_27304074_Chip-Seq_NSC_Mouse1.74458244
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74094349
41P300_19829295_ChIP-Seq_ESCs_Human1.72685973
42SMAD4_21799915_ChIP-Seq_A2780_Human1.65505092
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63080261
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60758527
45* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57929563
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.51025440
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47985456
48DROSHA_22980978_ChIP-Seq_HELA_Human1.41082489
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.40212687
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38413294
51VDR_22108803_ChIP-Seq_LS180_Human1.37761545
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36966571
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36944429
54ZNF274_21170338_ChIP-Seq_K562_Hela1.36502064
55* TP63_19390658_ChIP-ChIP_HaCaT_Human1.36190167
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34265716
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31883357
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31883357
59IGF1R_20145208_ChIP-Seq_DFB_Human1.31361357
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29896703
61FUS_26573619_Chip-Seq_HEK293_Human1.29620147
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28832159
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.27949496
64AR_21572438_ChIP-Seq_LNCaP_Human1.27271200
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.27262979
66* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26203290
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25894401
68* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25580115
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25431920
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24170382
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.23983742
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23450866
73* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21358750
74* STAT3_23295773_ChIP-Seq_U87_Human1.20492535
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19753904
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.19108521
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16993710
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16449217
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16222505
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14115472
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14009195
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13906190
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.13583018
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.13136183
85* SOX9_26525672_Chip-Seq_HEART_Mouse1.12329062
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11833203
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11214606
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09810747
89* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08916690
90* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08905719
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.08793083
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08194506
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07920977
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.07733691
95* TCF4_23295773_ChIP-Seq_U87_Human1.07623438
96TP53_18474530_ChIP-ChIP_U2OS_Human1.07546216
97AR_25329375_ChIP-Seq_VCAP_Human1.06930939
98JUN_21703547_ChIP-Seq_K562_Human1.06658692
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.06020881
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05140159
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.04690141
102ER_23166858_ChIP-Seq_MCF-7_Human1.04403891
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.03309593
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03099780
105* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02536035
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02166979
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00714385
108P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99996467
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.99864743
110AR_19668381_ChIP-Seq_PC3_Human0.99072952
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98823702
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.98779371
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98049598
114* KDM2B_26808549_Chip-Seq_REH_Human0.97559040
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97475138
116TCF4_22108803_ChIP-Seq_LS180_Human0.97455324
117CBP_20019798_ChIP-Seq_JUKART_Human0.97127700
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97127700
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96769630
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.96669125
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96062153
122P53_22387025_ChIP-Seq_ESCs_Mouse0.94686006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.77361952
2MP0003880_abnormal_central_pattern3.84079088
3MP0002638_abnormal_pupillary_reflex3.31977423
4* MP0003635_abnormal_synaptic_transmissio3.29151784
5MP0001188_hyperpigmentation3.09041426
6MP0004270_analgesia2.75191812
7MP0002063_abnormal_learning/memory/cond2.68603327
8MP0009745_abnormal_behavioral_response2.47242753
9MP0002735_abnormal_chemical_nociception2.41122772
10MP0006276_abnormal_autonomic_nervous2.39630036
11MP0001968_abnormal_touch/_nociception2.39523243
12MP0002572_abnormal_emotion/affect_behav2.35649672
13MP0002184_abnormal_innervation2.33401100
14MP0005423_abnormal_somatic_nervous2.32912470
15MP0005410_abnormal_fertilization2.32283925
16MP0002734_abnormal_mechanical_nocicepti2.29811173
17MP0002064_seizures2.29644403
18MP0009046_muscle_twitch2.24455590
19MP0000778_abnormal_nervous_system2.10426473
20MP0002736_abnormal_nociception_after2.10145098
21MP0001486_abnormal_startle_reflex2.07921786
22MP0001984_abnormal_olfaction2.06328663
23MP0002557_abnormal_social/conspecific_i1.92446563
24MP0002272_abnormal_nervous_system1.90134068
25MP0002733_abnormal_thermal_nociception1.89416216
26MP0004858_abnormal_nervous_system1.88468915
27MP0006292_abnormal_olfactory_placode1.86433298
28MP0002067_abnormal_sensory_capabilities1.85133073
29MP0005645_abnormal_hypothalamus_physiol1.78585455
30MP0001970_abnormal_pain_threshold1.68251879
31MP0004811_abnormal_neuron_physiology1.67569398
32MP0003890_abnormal_embryonic-extraembry1.66033719
33MP0001501_abnormal_sleep_pattern1.64608969
34MP0005499_abnormal_olfactory_system1.61075222
35MP0005394_taste/olfaction_phenotype1.61075222
36MP0002882_abnormal_neuron_morphology1.57880296
37MP0000955_abnormal_spinal_cord1.56516933
38MP0002653_abnormal_ependyma_morphology1.56135521
39MP0000537_abnormal_urethra_morphology1.54534074
40MP0002822_catalepsy1.54219702
41MP0001440_abnormal_grooming_behavior1.52750765
42MP0000631_abnormal_neuroendocrine_gland1.52230733
43MP0000569_abnormal_digit_pigmentation1.51709006
44MP0005187_abnormal_penis_morphology1.50448638
45MP0002102_abnormal_ear_morphology1.46388886
46MP0005551_abnormal_eye_electrophysiolog1.44765076
47MP0008569_lethality_at_weaning1.44303810
48MP0001485_abnormal_pinna_reflex1.43016548
49MP0002909_abnormal_adrenal_gland1.42098842
50MP0003787_abnormal_imprinting1.39215246
51MP0008789_abnormal_olfactory_epithelium1.38570846
52MP0003937_abnormal_limbs/digits/tail_de1.36664060
53MP0003698_abnormal_male_reproductive1.31025988
54MP0003122_maternal_imprinting1.29879509
55MP0005646_abnormal_pituitary_gland1.29830965
56MP0004924_abnormal_behavior1.29593164
57MP0005386_behavior/neurological_phenoty1.29593164
58MP0001502_abnormal_circadian_rhythm1.28802271
59MP0002752_abnormal_somatic_nervous1.27725464
60MP0003878_abnormal_ear_physiology1.27085355
61MP0005377_hearing/vestibular/ear_phenot1.27085355
62* MP0001293_anophthalmia1.26040159
63MP0004742_abnormal_vestibular_system1.25478330
64MP0002234_abnormal_pharynx_morphology1.25453494
65MP0003755_abnormal_palate_morphology1.25402803
66MP0002751_abnormal_autonomic_nervous1.25305487
67MP0005248_abnormal_Harderian_gland1.25086316
68MP0002066_abnormal_motor_capabilities/c1.24719601
69* MP0002152_abnormal_brain_morphology1.23563807
70MP0010030_abnormal_orbit_morphology1.21896900
71MP0003938_abnormal_ear_development1.20698011
72MP0009780_abnormal_chondrocyte_physiolo1.18827563
73* MP0001286_abnormal_eye_development1.16505156
74MP0000579_abnormal_nail_morphology1.11758854
75MP0003136_yellow_coat_color1.10184387
76MP0004133_heterotaxia1.08958346
77* MP0003861_abnormal_nervous_system1.06634628
78* MP0002697_abnormal_eye_size1.05917134
79MP0001905_abnormal_dopamine_level1.04953200
80MP0000427_abnormal_hair_cycle1.04267420
81MP0003879_abnormal_hair_cell1.02168482
82MP0010386_abnormal_urinary_bladder0.99399490
83MP0000534_abnormal_ureter_morphology0.99359806
84MP0006072_abnormal_retinal_apoptosis0.99213896
85MP0000647_abnormal_sebaceous_gland0.99208235
86MP0001529_abnormal_vocalization0.98704709
87MP0002938_white_spotting0.98507021
88MP0003119_abnormal_digestive_system0.97706240
89MP0002069_abnormal_eating/drinking_beha0.95128015
90MP0001963_abnormal_hearing_physiology0.89653706
91MP0002229_neurodegeneration0.88081112
92MP0005253_abnormal_eye_physiology0.86745836
93MP0003567_abnormal_fetal_cardiomyocyte0.86682449
94MP0002277_abnormal_respiratory_mucosa0.86201612
95MP0003935_abnormal_craniofacial_develop0.86041594
96MP0004085_abnormal_heartbeat0.84928585
97MP0004885_abnormal_endolymph0.84549889
98MP0000516_abnormal_urinary_system0.84138136
99MP0005367_renal/urinary_system_phenotyp0.84138136
100* MP0002081_perinatal_lethality0.83952772
101* MP0005391_vision/eye_phenotype0.82867850
102MP0000026_abnormal_inner_ear0.81635100
103MP0009053_abnormal_anal_canal0.80379871
104MP0003385_abnormal_body_wall0.79556491
105MP0008877_abnormal_DNA_methylation0.79167528
106MP0001986_abnormal_taste_sensitivity0.78434401
107MP0001177_atelectasis0.78398742
108MP0000428_abnormal_craniofacial_morphol0.78237082
109MP0005195_abnormal_posterior_eye0.77558338
110MP0003646_muscle_fatigue0.77389532
111MP0000566_synostosis0.75277748
112MP0003121_genomic_imprinting0.74075003
113MP0000049_abnormal_middle_ear0.72534238
114MP0002161_abnormal_fertility/fecundity0.72209794
115MP0002160_abnormal_reproductive_system0.71060719
116MP0002837_dystrophic_cardiac_calcinosis0.69903897
117MP0003283_abnormal_digestive_organ0.69316146
118MP0002249_abnormal_larynx_morphology0.68010713
119MP0004142_abnormal_muscle_tone0.67820400
120MP0002163_abnormal_gland_morphology0.67686352
121MP0000013_abnormal_adipose_tissue0.67323674
122MP0000681_abnormal_thyroid_gland0.67024041
123MP0001929_abnormal_gametogenesis0.66898439
124MP0003634_abnormal_glial_cell0.66446327
125MP0001299_abnormal_eye_distance/0.65722234
126MP0003329_amyloid_beta_deposits0.65074204
127MP0002876_abnormal_thyroid_physiology0.64610114
128MP0002233_abnormal_nose_morphology0.62846114
129MP0010770_preweaning_lethality0.61771596

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)7.30166930
2Abnormal gallbladder physiology (HP:0012438)7.30166930
3Peripheral hypomyelination (HP:0007182)6.85991100
4Decreased number of large peripheral myelinated nerve fibers (HP:0003387)6.24050904
5Focal motor seizures (HP:0011153)4.62756149
6Submucous cleft hard palate (HP:0000176)3.92214430
7Progressive cerebellar ataxia (HP:0002073)3.79430193
8Febrile seizures (HP:0002373)3.60475721
9Myokymia (HP:0002411)3.50068021
10Absent/shortened dynein arms (HP:0200106)3.49283816
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.49283816
12Focal seizures (HP:0007359)3.47665328
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41907988
14Septo-optic dysplasia (HP:0100842)3.23386029
15Epileptic encephalopathy (HP:0200134)3.18055606
16Akinesia (HP:0002304)3.17049406
17Atonic seizures (HP:0010819)3.15052234
18Popliteal pterygium (HP:0009756)3.07632574
19Abnormality of the labia minora (HP:0012880)3.00803358
20Decreased muscle mass (HP:0003199)2.92828586
21Aplasia/Hypoplasia of the brainstem (HP:0007362)2.83167079
22Hypoplasia of the brainstem (HP:0002365)2.83167079
23Cholelithiasis (HP:0001081)2.82743253
24Visual hallucinations (HP:0002367)2.76790683
25Volvulus (HP:0002580)2.66349318
26Depression (HP:0000716)2.61684693
27Retinal dysplasia (HP:0007973)2.54467343
28Abnormal gallbladder morphology (HP:0012437)2.53623138
29Abnormal respiratory motile cilium physiology (HP:0012261)2.53528403
30Optic nerve hypoplasia (HP:0000609)2.48432770
31Absence seizures (HP:0002121)2.47411513
32Pendular nystagmus (HP:0012043)2.43983638
33Decreased motor nerve conduction velocity (HP:0003431)2.43469303
34Intestinal atresia (HP:0011100)2.41909460
35Protruding tongue (HP:0010808)2.39501498
36Cortical dysplasia (HP:0002539)2.37235014
37Chin dimple (HP:0010751)2.37155454
38Hepatoblastoma (HP:0002884)2.34237376
39Action tremor (HP:0002345)2.33814506
40Amblyopia (HP:0000646)2.31469326
41* Absent eyebrow (HP:0002223)2.30838304
42Abnormal respiratory epithelium morphology (HP:0012253)2.29119743
43Abnormal respiratory motile cilium morphology (HP:0005938)2.29119743
44Gaze-evoked nystagmus (HP:0000640)2.28741938
45Reticulocytosis (HP:0001923)2.27698792
46* Anophthalmia (HP:0000528)2.25243827
47Progressive inability to walk (HP:0002505)2.24385609
48Chronic hepatic failure (HP:0100626)2.23595722
49Abnormality of the septum pellucidum (HP:0007375)2.23439734
50Pachygyria (HP:0001302)2.22548254
51Abnormality of the gallbladder (HP:0005264)2.21279123
52Limb dystonia (HP:0002451)2.20941461
53Megalencephaly (HP:0001355)2.20534033
54Hyperventilation (HP:0002883)2.20299810
55Gait imbalance (HP:0002141)2.18695475
56Dialeptic seizures (HP:0011146)2.18683511
57Oligodactyly (hands) (HP:0001180)2.18535144
58Generalized tonic-clonic seizures (HP:0002069)2.17821044
59Agitation (HP:0000713)2.17458092
60Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.15850247
61Absent septum pellucidum (HP:0001331)2.13702901
62Abnormal ciliary motility (HP:0012262)2.13566422
63Dysphonia (HP:0001618)2.09959206
64Bradykinesia (HP:0002067)2.09332352
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08025330
66Tented upper lip vermilion (HP:0010804)2.07659243
67Keratoconus (HP:0000563)2.05704855
68Increased corneal curvature (HP:0100692)2.05704855
69Genetic anticipation (HP:0003743)2.04706764
70Nephrogenic diabetes insipidus (HP:0009806)2.04223791
71Pancreatic cysts (HP:0001737)2.03693710
72True hermaphroditism (HP:0010459)2.01076211
73* Cutaneous finger syndactyly (HP:0010554)1.99663081
74Abnormality of midbrain morphology (HP:0002418)1.98893221
75Molar tooth sign on MRI (HP:0002419)1.98893221
76Specific learning disability (HP:0001328)1.97349388
77Pheochromocytoma (HP:0002666)1.97220889
78Hyperkalemia (HP:0002153)1.96580741
79Pancreatic fibrosis (HP:0100732)1.96105876
80Global brain atrophy (HP:0002283)1.95935096
81Medial flaring of the eyebrow (HP:0010747)1.95158640
82Lissencephaly (HP:0001339)1.94415921
83Gastrointestinal atresia (HP:0002589)1.93806253
84Absent speech (HP:0001344)1.91537844
85Failure to thrive in infancy (HP:0001531)1.91430991
86Aqueductal stenosis (HP:0002410)1.91200080
87Colon cancer (HP:0003003)1.90704816
88Epileptiform EEG discharges (HP:0011182)1.90503628
89Labial hypoplasia (HP:0000066)1.89110754
90Acanthocytosis (HP:0001927)1.88939913
91EEG with generalized epileptiform discharges (HP:0011198)1.88641225
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88033110
93Exotropia (HP:0000577)1.87684678
94Esophageal atresia (HP:0002032)1.87647593
95Truncal ataxia (HP:0002078)1.85516989
96Abnormality of the renal medulla (HP:0100957)1.84807388
97Broad-based gait (HP:0002136)1.83840089
98Abnormality of the corticospinal tract (HP:0002492)1.83031246
99Chorioretinal atrophy (HP:0000533)1.82954082
100Stereotypic behavior (HP:0000733)1.82294080
101Papillary thyroid carcinoma (HP:0002895)1.81523475
102Postaxial hand polydactyly (HP:0001162)1.81317260
103Abnormality of salivation (HP:0100755)1.80492330
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79849266
105Short 4th metacarpal (HP:0010044)1.79849266
106Drooling (HP:0002307)1.79237499
107Excessive salivation (HP:0003781)1.79237499
108Thickened helices (HP:0000391)1.78755701
109Widely spaced teeth (HP:0000687)1.78722309
110Nephronophthisis (HP:0000090)1.78698228
111Maternal diabetes (HP:0009800)1.77640873
112* Cupped ear (HP:0000378)1.76568151
113Thyroid-stimulating hormone excess (HP:0002925)1.76069343
114Congenital primary aphakia (HP:0007707)1.75924829
115Hypsarrhythmia (HP:0002521)1.75868514
116Dysdiadochokinesis (HP:0002075)1.75819150
117Long nose (HP:0003189)1.75354106
118Urinary urgency (HP:0000012)1.75017875
119Abnormal hair whorl (HP:0010721)1.74646087
120Impaired vibration sensation in the lower limbs (HP:0002166)1.74343050
121Urinary bladder sphincter dysfunction (HP:0002839)1.73958607
122Sclerocornea (HP:0000647)1.73761921
123Curly hair (HP:0002212)1.72084133
124Preaxial foot polydactyly (HP:0001841)1.71725967
125Intellectual disability, moderate (HP:0002342)1.71172892
126High anterior hairline (HP:0009890)1.70532821
127* Micropenis (HP:0000054)1.70201019
128Hypoplastic female external genitalia (HP:0012815)1.69869867
129Poor coordination (HP:0002370)1.69081740
130Supranuclear gaze palsy (HP:0000605)1.68651190
131Inability to walk (HP:0002540)1.68650979
132Polyphagia (HP:0002591)1.68551992
133* Renal hypoplasia (HP:0000089)1.68518409
134Spastic tetraplegia (HP:0002510)1.68494874
135Medulloblastoma (HP:0002885)1.67878151
136Rhinitis (HP:0012384)1.67668092
137Esotropia (HP:0000565)1.67646877
138Growth hormone deficiency (HP:0000824)1.67323065
139Narrow forehead (HP:0000341)1.67149914
140Fetal akinesia sequence (HP:0001989)1.67100878
141Hypoplastic labia majora (HP:0000059)1.66798548
142Impaired smooth pursuit (HP:0007772)1.66328041
143Gastroesophageal reflux (HP:0002020)1.66307748
144Shoulder girdle muscle weakness (HP:0003547)1.66103507
145Focal dystonia (HP:0004373)1.65627427
146Chorioretinal coloboma (HP:0000567)1.65185413
147Obsessive-compulsive behavior (HP:0000722)1.64937338
148Hyperthyroidism (HP:0000836)1.64169284
149Cerebellar dysplasia (HP:0007033)1.63274337
150Abnormality of the lower motor neuron (HP:0002366)1.62853887
151Type II lissencephaly (HP:0007260)1.62502843
152* Genital tract atresia (HP:0001827)1.62436919
153Amyotrophic lateral sclerosis (HP:0007354)1.62431229
154Hemiparesis (HP:0001269)1.61653335
155Thyroid carcinoma (HP:0002890)1.60663014
156Bony spicule pigmentary retinopathy (HP:0007737)1.60530612
157Abnormal social behavior (HP:0012433)1.59762480
158Impaired social interactions (HP:0000735)1.59762480
159Anxiety (HP:0000739)1.59552334
160* Aplasia/Hypoplasia of the sternum (HP:0006714)1.59454623
161* Cutaneous syndactyly (HP:0012725)1.59134964
162* Vaginal atresia (HP:0000148)1.59007503
163Open mouth (HP:0000194)1.58783663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.92112160
2MARK14.28453909
3PTK2B3.27988804
4NTRK33.12836175
5PNCK2.65543146
6CASK2.60843741
7MAP3K42.51325923
8TLK12.48505668
9MAP2K72.45260879
10TRIM282.42354094
11TESK12.33688913
12FRK2.30780328
13NTRK22.17395433
14MAPK132.07730707
15SGK21.92546863
16EPHA41.89564273
17BRAF1.81978216
18MINK11.81681634
19KSR21.75759375
20MAP3K21.72745140
21BLK1.71990197
22LIMK11.67277172
23MAP4K21.67186649
24PRKD31.62019211
25SGK4941.58451913
26SGK2231.58451913
27BMPR1B1.54282873
28DYRK31.47021915
29FGFR21.45486022
30PAK61.41757842
31SRPK11.39515914
32NUAK11.30750415
33LATS11.29563636
34MAP2K41.28891587
35SIK21.26049080
36CDK81.24563083
37UHMK11.21837158
38DYRK21.20628487
39PLK21.20205057
40EPHB21.18646477
41SGK31.18158905
42MAP3K91.16687852
43GRK51.14750182
44MKNK11.14616301
45ERBB31.13905698
46TNIK1.13832586
47TESK21.12783316
48PRPF4B1.06286879
49CDK51.04824344
50NME11.01790736
51CDC71.00545197
52PHKG10.99127223
53PHKG20.99127223
54PRKCG0.98124337
55SIK30.93223534
56CAMK2A0.92864212
57NTRK10.90018248
58BMPR20.85291180
59DAPK20.83705188
60MAP3K120.82868136
61LATS20.82332583
62DYRK1A0.81038753
63CSNK1G20.78860940
64TYRO30.77059637
65PINK10.76810378
66WNK40.75191944
67KSR10.74624227
68PAK30.74474365
69PDK40.71325863
70PDK30.71325863
71WNK10.70576349
72WNK30.69257327
73RET0.69153056
74FES0.67857897
75ERBB40.67670168
76CAMKK10.67637584
77STK380.66787808
78PLK40.65921188
79MARK20.65632787
80ZAK0.65116751
81PKN10.64567904
82ICK0.62454146
83STK390.62389596
84ADRBK20.61957034
85CAMKK20.59876696
86CDK30.58824419
87ERBB20.57885242
88EPHA30.55908451
89MAP2K10.55568198
90RPS6KA40.54730732
91CAMK2B0.54006896
92CSNK1E0.53478680
93GRK10.52626393
94OXSR10.52440400
95RPS6KA20.51579801
96PLK30.50311350
97MUSK0.50290611
98CAMK1G0.50147024
99CAMK10.50135999
100CSNK1D0.49890836
101SGK10.49725429
102VRK10.49659828
103IRAK10.49274591
104CSNK1G30.49177576
105MAP3K10.49068368
106CDC42BPA0.48449253
107CDK190.48007738
108CDK140.47589855
109ACVR1B0.47559217
110STK38L0.47387412
111CDK180.46971658
112PRKCE0.46814074
113ATM0.45924445
114BCR0.45731288
115MKNK20.44050452
116CDK150.43751251
117FGFR10.43435159
118INSRR0.42997262
119CSNK1A10.42155457
120DYRK1B0.41739072
121PRKCZ0.40942074
122NEK20.39587222
123BRD40.38748137
124PLK10.37931981
125MAP3K60.37837701
126CAMK40.37283195
127PRKDC0.37261876
128CSNK1A1L0.37246525
129CAMK1D0.36931041
130GSK3B0.36700935
131CDK11A0.36036426
132STK110.35544531
133TAF10.35038460
134CDK10.34259169
135FER0.33510364
136YES10.33235491
137PRKG10.32346569
138PRKACA0.32266293
139CSNK1G10.31923007
140PRKCB0.31779012
141MAPK150.31578829
142PRKACB0.31522710
143MAPK90.30246491

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005247.79913784
2Nicotine addiction_Homo sapiens_hsa050333.27619277
3Synaptic vesicle cycle_Homo sapiens_hsa047212.80724970
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29170064
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15450023
6Olfactory transduction_Homo sapiens_hsa047402.11548955
7Taste transduction_Homo sapiens_hsa047422.09753437
8GABAergic synapse_Homo sapiens_hsa047272.04151801
9Long-term potentiation_Homo sapiens_hsa047202.02729040
10Type II diabetes mellitus_Homo sapiens_hsa049301.96080290
11Glutamatergic synapse_Homo sapiens_hsa047241.95020084
12Steroid biosynthesis_Homo sapiens_hsa001001.94176987
13Circadian entrainment_Homo sapiens_hsa047131.91122935
14Morphine addiction_Homo sapiens_hsa050321.90130963
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.87538533
16Insulin secretion_Homo sapiens_hsa049111.85255204
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80800490
18Amphetamine addiction_Homo sapiens_hsa050311.72539970
19Dopaminergic synapse_Homo sapiens_hsa047281.68728993
20Collecting duct acid secretion_Homo sapiens_hsa049661.65574537
21Serotonergic synapse_Homo sapiens_hsa047261.62129229
22Basal transcription factors_Homo sapiens_hsa030221.54697204
23Long-term depression_Homo sapiens_hsa047301.49364177
24Cholinergic synapse_Homo sapiens_hsa047251.46681335
25Hippo signaling pathway_Homo sapiens_hsa043901.40663080
26Axon guidance_Homo sapiens_hsa043601.39857944
27Salivary secretion_Homo sapiens_hsa049701.35404334
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31324436
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30558414
30Butanoate metabolism_Homo sapiens_hsa006501.28870305
31Phototransduction_Homo sapiens_hsa047441.28406632
32Cardiac muscle contraction_Homo sapiens_hsa042601.27419956
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26255352
34Cocaine addiction_Homo sapiens_hsa050301.23384738
35Fanconi anemia pathway_Homo sapiens_hsa034601.21225223
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18755028
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17522877
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12975942
39Renin secretion_Homo sapiens_hsa049241.08754855
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07628852
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07610353
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05764211
43Calcium signaling pathway_Homo sapiens_hsa040201.02023556
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00045294
45Fructose and mannose metabolism_Homo sapiens_hsa000510.97727763
46Glioma_Homo sapiens_hsa052140.96643527
47RNA degradation_Homo sapiens_hsa030180.96499309
48Oxytocin signaling pathway_Homo sapiens_hsa049210.95839363
49Gastric acid secretion_Homo sapiens_hsa049710.94281179
50Protein export_Homo sapiens_hsa030600.94265453
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93053425
52ErbB signaling pathway_Homo sapiens_hsa040120.92543925
53Tight junction_Homo sapiens_hsa045300.92294042
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92210411
55cAMP signaling pathway_Homo sapiens_hsa040240.91405237
56Ether lipid metabolism_Homo sapiens_hsa005650.90459534
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89821590
58Gap junction_Homo sapiens_hsa045400.89464268
59Galactose metabolism_Homo sapiens_hsa000520.88638544
60Melanogenesis_Homo sapiens_hsa049160.88095737
61Estrogen signaling pathway_Homo sapiens_hsa049150.85359792
62Vibrio cholerae infection_Homo sapiens_hsa051100.83058424
63Endometrial cancer_Homo sapiens_hsa052130.81700163
64Nitrogen metabolism_Homo sapiens_hsa009100.80721571
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.78959068
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77788747
67GnRH signaling pathway_Homo sapiens_hsa049120.77607927
68Ovarian steroidogenesis_Homo sapiens_hsa049130.76439315
69Oxidative phosphorylation_Homo sapiens_hsa001900.74474604
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73950938
71Selenocompound metabolism_Homo sapiens_hsa004500.73037173
72Dorso-ventral axis formation_Homo sapiens_hsa043200.72892145
73Hedgehog signaling pathway_Homo sapiens_hsa043400.72240248
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70517567
75Non-homologous end-joining_Homo sapiens_hsa034500.68853078
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68597233
77Linoleic acid metabolism_Homo sapiens_hsa005910.68464598
78Oocyte meiosis_Homo sapiens_hsa041140.68441539
79mRNA surveillance pathway_Homo sapiens_hsa030150.67982120
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67642125
81Alcoholism_Homo sapiens_hsa050340.66824095
82Regulation of autophagy_Homo sapiens_hsa041400.66143799
83Adherens junction_Homo sapiens_hsa045200.65707279
84Alzheimers disease_Homo sapiens_hsa050100.64906926
85Type I diabetes mellitus_Homo sapiens_hsa049400.64873983
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64421294
87Insulin signaling pathway_Homo sapiens_hsa049100.63758643
88Circadian rhythm_Homo sapiens_hsa047100.62470840
89TGF-beta signaling pathway_Homo sapiens_hsa043500.61819163
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.61437761
91RNA transport_Homo sapiens_hsa030130.60770054
92Melanoma_Homo sapiens_hsa052180.60743169
93Colorectal cancer_Homo sapiens_hsa052100.60481987
94Wnt signaling pathway_Homo sapiens_hsa043100.60110520
95Huntingtons disease_Homo sapiens_hsa050160.59272110
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58492732
97MAPK signaling pathway_Homo sapiens_hsa040100.57253147
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54570721
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54230073
100Basal cell carcinoma_Homo sapiens_hsa052170.54010525
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50608829
102Parkinsons disease_Homo sapiens_hsa050120.50312514
103Renal cell carcinoma_Homo sapiens_hsa052110.50078825
104Glucagon signaling pathway_Homo sapiens_hsa049220.49793729
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49715452
106Pancreatic secretion_Homo sapiens_hsa049720.49065464
107Choline metabolism in cancer_Homo sapiens_hsa052310.47867991
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47838053
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46948438
110Propanoate metabolism_Homo sapiens_hsa006400.46563073
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46345999
112Thyroid hormone synthesis_Homo sapiens_hsa049180.45362889
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45151760
114RNA polymerase_Homo sapiens_hsa030200.44498545
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43116750
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.41129841
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39478081
118mTOR signaling pathway_Homo sapiens_hsa041500.38919934
119Ras signaling pathway_Homo sapiens_hsa040140.38350950
120Fatty acid biosynthesis_Homo sapiens_hsa000610.37951514
121Rap1 signaling pathway_Homo sapiens_hsa040150.37810209
122Cell cycle_Homo sapiens_hsa041100.37425753
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37228328
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37024202
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36542721
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35686330
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35624584
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34653499
129Thyroid cancer_Homo sapiens_hsa052160.32778189
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.32189010
131Starch and sucrose metabolism_Homo sapiens_hsa005000.31570856
132Non-small cell lung cancer_Homo sapiens_hsa052230.31551993
133Inositol phosphate metabolism_Homo sapiens_hsa005620.27448466
134HIF-1 signaling pathway_Homo sapiens_hsa040660.26422400
135Sulfur metabolism_Homo sapiens_hsa009200.25914487
136Dilated cardiomyopathy_Homo sapiens_hsa054140.25593968
137Endocytosis_Homo sapiens_hsa041440.25317098

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