GRIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.97300750
2muscle filament sliding (GO:0030049)8.77836736
3actin-myosin filament sliding (GO:0033275)8.77836736
4proteasome assembly (GO:0043248)7.28207834
5actin-mediated cell contraction (GO:0070252)7.24306659
6sarcoplasmic reticulum calcium ion transport (GO:0070296)7.24160320
7regulation of skeletal muscle contraction (GO:0014819)6.62310761
8mitotic sister chromatid cohesion (GO:0007064)6.46206640
9myofibril assembly (GO:0030239)6.33875210
10skeletal muscle contraction (GO:0003009)6.15590303
11regulation of relaxation of muscle (GO:1901077)6.08412281
12sarcomere organization (GO:0045214)6.06890733
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.68242475
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.65591568
15response to muscle activity (GO:0014850)5.61287589
16striated muscle contraction (GO:0006941)5.47216213
17negative regulation of viral genome replication (GO:0045071)5.46265847
18DNA deamination (GO:0045006)5.36465176
19response to interferon-alpha (GO:0035455)5.27769507
20actin filament-based movement (GO:0030048)5.17254547
21response to peptidoglycan (GO:0032494)5.11391774
22oxidative demethylation (GO:0070989)5.11242700
23regulation of cell communication by electrical coupling (GO:0010649)4.99862948
24cardiac myofibril assembly (GO:0055003)4.97040112
25regulation of T cell chemotaxis (GO:0010819)4.94175236
26positive regulation of T cell chemotaxis (GO:0010820)4.94175236
27response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.87474398
28cardiac muscle contraction (GO:0060048)4.65855905
29mature B cell differentiation (GO:0002335)4.57579584
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.51602657
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.49461973
32response to inactivity (GO:0014854)4.43484163
33regulation of actin filament-based movement (GO:1903115)4.39076952
34muscle contraction (GO:0006936)4.34859278
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.32444343
36actomyosin structure organization (GO:0031032)4.31405795
37cardiac muscle hypertrophy (GO:0003300)4.20494668
38creatine metabolic process (GO:0006600)4.10325353
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.06061530
40positive regulation of viral genome replication (GO:0045070)4.05901982
41facial nerve structural organization (GO:0021612)4.04020939
42regulation of membrane repolarization (GO:0060306)4.03242889
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.01736114
44striated muscle hypertrophy (GO:0014897)4.00017980
45muscle fiber development (GO:0048747)3.96837240
46muscle system process (GO:0003012)3.95019054
47skeletal muscle fiber development (GO:0048741)3.93463342
48negative regulation of T-helper cell differentiation (GO:0045623)3.92473818
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.92473818
50carnitine shuttle (GO:0006853)3.86124822
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.85206633
52positive regulation of tolerance induction (GO:0002645)3.84576238
53bundle of His cell to Purkinje myocyte communication (GO:0086069)3.80678133
54regulation of T-helper 1 cell differentiation (GO:0045625)3.77589404
55myotube cell development (GO:0014904)3.74787473
56regulation of histone H3-K9 methylation (GO:0051570)3.74696703
57nuclear pore complex assembly (GO:0051292)3.74464735
58respiratory tube development (GO:0030323)3.74064766
59carnitine transmembrane transport (GO:1902603)3.74058112
60sperm motility (GO:0030317)3.71053785
61neuromuscular synaptic transmission (GO:0007274)3.68768526
62skeletal muscle adaptation (GO:0043501)3.68036168
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67923840
64fusion of sperm to egg plasma membrane (GO:0007342)3.67484210
65muscle cell cellular homeostasis (GO:0046716)3.65550133
66regulation of striated muscle contraction (GO:0006942)3.64751517
67pre-miRNA processing (GO:0031054)3.64624622
68meiotic chromosome segregation (GO:0045132)3.63563742
69regulation of T-helper 2 cell differentiation (GO:0045628)3.63506532
70protein K6-linked ubiquitination (GO:0085020)3.61890472
71negative regulation of interleukin-12 production (GO:0032695)3.60000493
72neuronal action potential propagation (GO:0019227)3.56029678
73adult heart development (GO:0007512)3.54871385
74negative regulation of potassium ion transmembrane transport (GO:1901380)3.54194354
75carnitine transport (GO:0015879)3.53421906
76amino-acid betaine transport (GO:0015838)3.53421906
77motile cilium assembly (GO:0044458)3.52013943
78urea cycle (GO:0000050)3.50107610
79urea metabolic process (GO:0019627)3.50107610
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49278433
81plasma membrane repair (GO:0001778)3.49126169
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48376663
83nuclear pore organization (GO:0006999)3.45999659
84cartilage morphogenesis (GO:0060536)3.44279255
85muscle hypertrophy (GO:0014896)3.44078311
86DNA packaging (GO:0006323)3.41770883
87piRNA metabolic process (GO:0034587)3.41598545
88regulation of tolerance induction (GO:0002643)3.38774851
89chromatin assembly (GO:0031497)3.36616805
90negative regulation of calcium ion transmembrane transport (GO:1903170)3.35673929
91negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.35673929
92regulation of viral genome replication (GO:0045069)3.35431273
93positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.34989812
94plasma lipoprotein particle assembly (GO:0034377)3.34209803
95striated muscle adaptation (GO:0014888)3.34003149
96sperm-egg recognition (GO:0035036)3.32552775
97cardiac muscle tissue morphogenesis (GO:0055008)3.31744874
98genitalia morphogenesis (GO:0035112)3.31578249
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31406769
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30780995
101phospholipid efflux (GO:0033700)3.30598889
102binding of sperm to zona pellucida (GO:0007339)3.28571724
103response to folic acid (GO:0051593)3.28274386
104fatty acid transmembrane transport (GO:1902001)3.27848628
105positive regulation of gamma-delta T cell activation (GO:0046645)3.27176925
106muscle tissue morphogenesis (GO:0060415)3.25426523
107membrane depolarization during action potential (GO:0086010)3.22767373
108regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22114441
109regulation of calcium ion transmembrane transport (GO:1903169)3.22114441
110negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20858947
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20110644
112B cell mediated immunity (GO:0019724)3.18521170
113sister chromatid cohesion (GO:0007062)3.16493793
114regulation of NFAT protein import into nucleus (GO:0051532)3.14425135
115negative regulation of viral entry into host cell (GO:0046597)3.12857097
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10762659
117regulation of fatty acid oxidation (GO:0046320)3.09944368
118regulation of histone H3-K27 methylation (GO:0061085)3.09854527
119cell-cell recognition (GO:0009988)3.09427802
120negative regulation of gluconeogenesis (GO:0045721)3.08898538
121response to interferon-beta (GO:0035456)3.08805723
122toxin transport (GO:1901998)3.08458445
123striated muscle cell development (GO:0055002)3.08211074
124DNA methylation involved in gamete generation (GO:0043046)3.07834217
125cardiac muscle cell development (GO:0055013)3.07787055
126nitrogen cycle metabolic process (GO:0071941)3.07392649
127postsynaptic membrane organization (GO:0001941)3.05700268
128positive regulation of cation channel activity (GO:2001259)3.03989223
129detection of calcium ion (GO:0005513)3.03254425
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01863285
131muscle structure development (GO:0061061)2.99999470
132DNA ligation (GO:0006266)2.99744770
133muscle organ development (GO:0007517)2.99535137
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99183707
135cardiac muscle adaptation (GO:0014887)2.97356569
136cardiac muscle hypertrophy in response to stress (GO:0014898)2.97356569
137muscle hypertrophy in response to stress (GO:0003299)2.97356569
138negative regulation of protein localization to cell surface (GO:2000009)2.94606999
139negative regulation of erythrocyte differentiation (GO:0045647)2.93936429
140regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.91672886
141regulation of macrophage cytokine production (GO:0010935)2.91621451
142skeletal muscle tissue development (GO:0007519)2.91601227
143protein-lipid complex assembly (GO:0065005)2.91500420
144glycogen catabolic process (GO:0005980)2.90148610
145cardiac muscle cell action potential (GO:0086001)2.89928868
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89591822
147regulation of potassium ion transmembrane transporter activity (GO:1901016)2.89367240
148gap junction assembly (GO:0016264)2.88665421
149positive regulation of histone methylation (GO:0031062)2.88563604
150regulation of mRNA 3-end processing (GO:0031440)2.87237857
151negative regulation of type 2 immune response (GO:0002829)2.87001921
152negative regulation of alpha-beta T cell differentiation (GO:0046639)2.86592518
153otic vesicle formation (GO:0030916)2.86052025
154ventricular cardiac muscle cell action potential (GO:0086005)2.85037726
155heart process (GO:0003015)2.84839151
156heart contraction (GO:0060047)2.84839151
157acrosome reaction (GO:0007340)2.84201145
158striated muscle atrophy (GO:0014891)2.83934711
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81966896
160cardiac cell development (GO:0055006)2.81127515
161definitive hemopoiesis (GO:0060216)2.79237676
162relaxation of muscle (GO:0090075)2.78373488
163cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77894253
164positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.77046292
165embryonic retina morphogenesis in camera-type eye (GO:0060059)2.76483197
166cardiac muscle cell action potential involved in contraction (GO:0086002)2.75832282
167positive regulation of cholesterol efflux (GO:0010875)2.75788572
168positive regulation of NF-kappaB import into nucleus (GO:0042346)2.74508407
169positive regulation of transcription factor import into nucleus (GO:0042993)2.74492894
170response to nitrosative stress (GO:0051409)2.73407492
171phospholipid scrambling (GO:0017121)2.73306272
172regulation of sarcomere organization (GO:0060297)2.72256706
173negative regulation of stress fiber assembly (GO:0051497)2.71581095
174cranial nerve structural organization (GO:0021604)2.71059176
175response to caffeine (GO:0031000)2.70988300
176myoblast migration (GO:0051451)2.70328117
177modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70054730
178modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70054730
179positive regulation by organism of defense response of other organism involved in symbiotic interact2.70054730
180modulation by symbiont of host immune response (GO:0052553)2.70054730
181positive regulation by symbiont of host defense response (GO:0052509)2.70054730
182modulation by symbiont of host defense response (GO:0052031)2.70054730
183regulation of ATPase activity (GO:0043462)2.69912493
184regulation of ATP catabolic process (GO:1903289)2.69912493
185thalamus development (GO:0021794)2.69774724
186establishment of apical/basal cell polarity (GO:0035089)2.69658958
187production of molecular mediator involved in inflammatory response (GO:0002532)2.69156880
188ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.69066001
189muscle cell development (GO:0055001)2.67822937
190glucan catabolic process (GO:0009251)2.67196364
191glycogen biosynthetic process (GO:0005978)2.65275149
192glucan biosynthetic process (GO:0009250)2.65275149
193regulation of synapse maturation (GO:0090128)2.62369207
194regulation of cation channel activity (GO:2001257)2.61808324
195muscle atrophy (GO:0014889)2.61703702
196regulation of myoblast differentiation (GO:0045661)2.60782114
197regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59093676
198regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58703589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.53487073
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.33881644
3NOTCH1_21737748_ChIP-Seq_TLL_Human4.65820568
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79163302
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.60195005
6GBX2_23144817_ChIP-Seq_PC3_Human3.39834387
7PPARD_23208498_ChIP-Seq_MDA-MB-231_Human3.09914683
8EZH2_22144423_ChIP-Seq_EOC_Human3.01844456
9GATA1_22025678_ChIP-Seq_K562_Human2.96640438
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93433176
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93433176
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93433176
13SCL_19346495_ChIP-Seq_HPC-7_Human2.93204525
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75286618
15E2F7_22180533_ChIP-Seq_HELA_Human2.66623922
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65991772
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.65583005
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63530606
19ZNF274_21170338_ChIP-Seq_K562_Hela2.56085151
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41616502
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.30244691
22VDR_22108803_ChIP-Seq_LS180_Human2.22948123
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.09046703
24IGF1R_20145208_ChIP-Seq_DFB_Human2.03970974
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03268505
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01396485
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.97086074
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96934794
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94130903
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.93378937
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.92845268
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91757350
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88864535
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86164838
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84968737
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82986133
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81221498
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80710186
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79437679
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.77993033
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.77554582
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.73899110
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.73361912
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73115841
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72799996
46AR_21572438_ChIP-Seq_LNCaP_Human1.71538550
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70377991
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67697004
49FUS_26573619_Chip-Seq_HEK293_Human1.63878823
50DROSHA_22980978_ChIP-Seq_HELA_Human1.63131756
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62759435
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61427498
53TAF15_26573619_Chip-Seq_HEK293_Human1.60850992
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59429517
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59414992
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57525758
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55675044
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55568872
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55568872
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54779737
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.53099746
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52625096
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51378026
64SMAD4_21799915_ChIP-Seq_A2780_Human1.50918846
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49486446
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48811726
67* REST_21632747_ChIP-Seq_MESCs_Mouse1.48231133
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47336950
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47108763
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46772585
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46417298
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.44526779
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.42669911
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.42471375
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41304387
76P300_19829295_ChIP-Seq_ESCs_Human1.40808327
77MYC_22102868_ChIP-Seq_BL_Human1.40188238
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39953013
79PU_27001747_Chip-Seq_BMDM_Mouse1.39526908
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.38577737
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36893578
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.36726064
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35821661
84EGR1_19032775_ChIP-ChIP_M12_Human1.35405795
85* CBP_20019798_ChIP-Seq_JUKART_Human1.35149596
86* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35149596
87ER_23166858_ChIP-Seq_MCF-7_Human1.33476762
88* REST_18959480_ChIP-ChIP_MESCs_Mouse1.32574266
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.32476501
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30685385
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30393723
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28758293
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28466758
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28288417
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.27770890
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.27524426
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26877159
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26343602
99ETS1_22383799_ChIP-Seq_G1ME_Mouse1.26228007
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.25472887
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24272584
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24136539
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23065338
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21801686
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21699276
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21629474
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20968819
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19656577
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19354037
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19267255
111AR_25329375_ChIP-Seq_VCAP_Human1.18866129
112MAF_26560356_Chip-Seq_TH1_Human1.18775424
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.18399512
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17877976
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17877976
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17676513
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17456728
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17328011
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.16928333
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16475801
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15118233
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15044573
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14882769
124RNF2_27304074_Chip-Seq_NSC_Mouse1.14382475
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13980690
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12251322
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.12168341
128ZNF263_19887448_ChIP-Seq_K562_Human1.12109342
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12064495
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11316208
131* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09966672
132BCAT_22108803_ChIP-Seq_LS180_Human1.08462674
133P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06879161
134ESR1_20079471_ChIP-ChIP_T-47D_Human1.06163702
135FOXM1_23109430_ChIP-Seq_U2OS_Human1.05971816
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05204292
137TCF4_23295773_ChIP-Seq_U87_Human1.04344401
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04094499
139CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03573391
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03026806
141STAT3_23295773_ChIP-Seq_U87_Human1.02893232
142NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02157562
143RARB_27405468_Chip-Seq_BRAIN_Mouse1.00926420
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00847578
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00713161
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00678508
147HTT_18923047_ChIP-ChIP_STHdh_Human1.00242049
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99029076
149* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98517056
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.98269811
151VDR_21846776_ChIP-Seq_THP-1_Human0.97607188
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97526911
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.97255044
154HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96449936
155AR_19668381_ChIP-Seq_PC3_Human0.95609922
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94329302
157MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93878765
158* CTCF_27219007_Chip-Seq_Bcells_Human0.92826269
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.92693800
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92632376
161SOX2_19829295_ChIP-Seq_ESCs_Human0.91805021
162NANOG_19829295_ChIP-Seq_ESCs_Human0.91805021
163IRF1_19129219_ChIP-ChIP_H3396_Human0.91695760
164MYB_26560356_Chip-Seq_TH1_Human0.91680362
165SPI1_20517297_ChIP-Seq_HL60_Human0.90361516
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90173383
167HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88362193
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88041592
169GATA1_26923725_Chip-Seq_HPCs_Mouse0.88036283
170STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87856820
171TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87401488
172CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86193100
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85245981
174FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84386440
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84381680
176* BRD4_25478319_ChIP-Seq_HGPS_Human0.83757428
177SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80827589
178SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80827589
179EZH2_27294783_Chip-Seq_NPCs_Mouse0.80124245
180PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79553693
181NCOR1_26117541_ChIP-Seq_K562_Human0.79155127
182STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78295604
183KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77956102
184GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76943853
185STAT1_17558387_ChIP-Seq_HELA_Human0.74911541
186MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74445081
187UTX_26944678_Chip-Seq_JUKART_Human0.74079772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.89460011
2MP0003646_muscle_fatigue4.59180520
3MP0002009_preneoplasia4.39982859
4MP0002837_dystrophic_cardiac_calcinosis4.26650881
5MP0005410_abnormal_fertilization3.99010926
6MP0004036_abnormal_muscle_relaxation3.74262293
7MP0004084_abnormal_cardiac_muscle3.65011263
8MP0006292_abnormal_olfactory_placode3.10671004
9MP0004808_abnormal_hematopoietic_stem2.97540116
10MP0004215_abnormal_myocardial_fiber2.79946164
11MP0009697_abnormal_copulation2.77504072
12MP0009379_abnormal_foot_pigmentation2.68475438
13MP0002106_abnormal_muscle_physiology2.59417205
14MP0000749_muscle_degeneration2.55740748
15MP0010030_abnormal_orbit_morphology2.55134140
16MP0005330_cardiomyopathy2.54622824
17MP0005620_abnormal_muscle_contractility2.54538862
18MP0004087_abnormal_muscle_fiber2.51452036
19MP0002139_abnormal_hepatobiliary_system2.43086773
20MP0002269_muscular_atrophy2.39978616
21MP0003705_abnormal_hypodermis_morpholog2.37849852
22MP0000759_abnormal_skeletal_muscle2.37012497
23MP0005369_muscle_phenotype2.35041228
24MP0003943_abnormal_hepatobiliary_system2.16259275
25MP0004145_abnormal_muscle_electrophysio2.09939591
26MP0010094_abnormal_chromosome_stability2.07711355
27MP0002972_abnormal_cardiac_muscle2.00313224
28MP0005248_abnormal_Harderian_gland1.98475177
29MP0001661_extended_life_span1.96089692
30MP0003136_yellow_coat_color1.94092874
31MP0000685_abnormal_immune_system1.93280917
32MP0010352_gastrointestinal_tract_polyps1.92289114
33MP0001346_abnormal_lacrimal_gland1.85075516
34MP0002332_abnormal_exercise_endurance1.82851182
35MP0002877_abnormal_melanocyte_morpholog1.82704212
36MP0001293_anophthalmia1.81371655
37MP0000490_abnormal_crypts_of1.78965515
38MP0004510_myositis1.78877116
39MP0002108_abnormal_muscle_morphology1.77620024
40MP0004484_altered_response_of1.77394065
41MP0004859_abnormal_synaptic_plasticity1.76061977
42MP0002822_catalepsy1.71619709
43MP0005623_abnormal_meninges_morphology1.65523579
44MP0005408_hypopigmentation1.63562646
45MP0004233_abnormal_muscle_weight1.62985515
46MP0000013_abnormal_adipose_tissue1.62486553
47MP0005171_absent_coat_pigmentation1.61532217
48MP0005085_abnormal_gallbladder_physiolo1.61372873
49MP0003137_abnormal_impulse_conducting1.60302492
50MP0006036_abnormal_mitochondrial_physio1.59766154
51MP0001929_abnormal_gametogenesis1.59607815
52MP0001984_abnormal_olfaction1.59023462
53MP0010329_abnormal_lipoprotein_level1.53225249
54MP0005360_urolithiasis1.49103959
55MP0005451_abnormal_body_composition1.48857969
56MP0003436_decreased_susceptibility_to1.46752001
57MP0002166_altered_tumor_susceptibility1.43674330
58MP0009672_abnormal_birth_weight1.43075856
59MP0005385_cardiovascular_system_phenoty1.42120100
60MP0001544_abnormal_cardiovascular_syste1.42120100
61MP0002909_abnormal_adrenal_gland1.38637454
62MP0003698_abnormal_male_reproductive1.37618259
63MP0009780_abnormal_chondrocyte_physiolo1.36967538
64MP0008877_abnormal_DNA_methylation1.36348342
65MP0002092_abnormal_eye_morphology1.35632372
66MP0002638_abnormal_pupillary_reflex1.35596584
67MP0002396_abnormal_hematopoietic_system1.34033866
68MP0003283_abnormal_digestive_organ1.33739073
69MP0006138_congestive_heart_failure1.33641136
70MP0002127_abnormal_cardiovascular_syste1.31757593
71MP0005075_abnormal_melanosome_morpholog1.31627663
72MP0003635_abnormal_synaptic_transmissio1.31431598
73MP0004270_analgesia1.31134034
74MP0001348_abnormal_lacrimal_gland1.30666449
75MP0002272_abnormal_nervous_system1.30258813
76MP0000750_abnormal_muscle_regeneration1.30241034
77MP0002210_abnormal_sex_determination1.28645887
78MP0005409_darkened_coat_color1.28080729
79MP0004085_abnormal_heartbeat1.27840589
80MP0003303_peritoneal_inflammation1.26428002
81MP0005083_abnormal_biliary_tract1.25748133
82MP0008775_abnormal_heart_ventricle1.24870866
83MP0001145_abnormal_male_reproductive1.23161894
84MP0005365_abnormal_bile_salt1.22201619
85MP0001915_intracranial_hemorrhage1.21544526
86MP0002735_abnormal_chemical_nociception1.21524472
87MP0010307_abnormal_tumor_latency1.18484228
88MP0003868_abnormal_feces_composition1.18311432
89MP0009703_decreased_birth_body1.17974088
90MP0002734_abnormal_mechanical_nocicepti1.17917595
91MP0005423_abnormal_somatic_nervous1.16891390
92MP0009745_abnormal_behavioral_response1.16711833
93MP0000733_abnormal_muscle_development1.16086220
94MP0002282_abnormal_trachea_morphology1.15956504
95MP0001486_abnormal_startle_reflex1.15035084
96MP0010630_abnormal_cardiac_muscle1.15017093
97MP0002006_tumorigenesis1.14930170
98MP0002177_abnormal_outer_ear1.12748362
99MP0004197_abnormal_fetal_growth/weight/1.12597559
100MP0000767_abnormal_smooth_muscle1.11026211
101MP0009046_muscle_twitch1.07737002
102MP0000579_abnormal_nail_morphology1.07644803
103MP0001188_hyperpigmentation1.06559762
104MP0004381_abnormal_hair_follicle1.04570860
105MP0001340_abnormal_eyelid_morphology1.04404338
106MP0001879_abnormal_lymphatic_vessel1.02206593
107MP0005266_abnormal_metabolism0.99848816
108MP0004142_abnormal_muscle_tone0.99512217
109MP0001501_abnormal_sleep_pattern0.99247106
110MP0002064_seizures0.98767665
111MP0002063_abnormal_learning/memory/cond0.98425795
112MP0005174_abnormal_tail_pigmentation0.96702799
113MP0002102_abnormal_ear_morphology0.95220242
114MP0002932_abnormal_joint_morphology0.95045865
115MP0002277_abnormal_respiratory_mucosa0.95042601
116MP0002572_abnormal_emotion/affect_behav0.91364640
117MP0000653_abnormal_sex_gland0.90806051
118MP0003300_gastrointestinal_ulcer0.90223367
119MP0001968_abnormal_touch/_nociception0.88302146
120MP0006276_abnormal_autonomic_nervous0.88063344
121MP0003938_abnormal_ear_development0.86153577
122MP0003936_abnormal_reproductive_system0.86128518
123MP0005197_abnormal_uvea_morphology0.84965873
124MP0008770_decreased_survivor_rate0.83848201
125MP0001986_abnormal_taste_sensitivity0.82629544
126MP0003879_abnormal_hair_cell0.82471916
127MP0003115_abnormal_respiratory_system0.82349833
128MP0003252_abnormal_bile_duct0.81992733
129MP0000747_muscle_weakness0.81662913
130MP0005187_abnormal_penis_morphology0.80972235
131MP0002161_abnormal_fertility/fecundity0.80541180
132MP0008058_abnormal_DNA_repair0.80478576
133MP0000566_synostosis0.80267497
134MP0004924_abnormal_behavior0.80261510
135MP0005386_behavior/neurological_phenoty0.80261510
136MP0001529_abnormal_vocalization0.80000160
137MP0000049_abnormal_middle_ear0.79902508
138MP0001299_abnormal_eye_distance/0.79457495
139MP0002138_abnormal_hepatobiliary_system0.79086634
140MP0002067_abnormal_sensory_capabilities0.78797216
141MP0002163_abnormal_gland_morphology0.78242958
142MP0005646_abnormal_pituitary_gland0.77624449
143MP0005167_abnormal_blood-brain_barrier0.77330243
144MP0001800_abnormal_humoral_immune0.76946310
145MP0000432_abnormal_head_morphology0.75805393
146MP0001502_abnormal_circadian_rhythm0.75078192
147MP0003787_abnormal_imprinting0.74863032
148MP0009250_abnormal_appendicular_skeleto0.74761294
149MP0002086_abnormal_extraembryonic_tissu0.73521190
150MP0003077_abnormal_cell_cycle0.72450784
151MP0001958_emphysema0.71514751
152MP0008789_abnormal_olfactory_epithelium0.71234597
153MP0003806_abnormal_nucleotide_metabolis0.71079064
154MP0003448_altered_tumor_morphology0.70686452
155MP0003221_abnormal_cardiomyocyte_apopto0.70242683
156MP0006072_abnormal_retinal_apoptosis0.70012854
157MP0005670_abnormal_white_adipose0.68780193
158MP0002723_abnormal_immune_serum0.68758745
159MP0003935_abnormal_craniofacial_develop0.67600656
160MP0003123_paternal_imprinting0.67540661
161MP0001440_abnormal_grooming_behavior0.67442037
162MP0002066_abnormal_motor_capabilities/c0.67047743
163MP0002736_abnormal_nociception_after0.66520382
164MP0005253_abnormal_eye_physiology0.66144807
165MP0002128_abnormal_blood_circulation0.65948053
166MP0001485_abnormal_pinna_reflex0.65169838
167MP0008569_lethality_at_weaning0.64849687
168MP0002095_abnormal_skin_pigmentation0.64321494
169MP0002249_abnormal_larynx_morphology0.64206104
170MP0000516_abnormal_urinary_system0.63977300
171MP0005367_renal/urinary_system_phenotyp0.63977300
172MP0001970_abnormal_pain_threshold0.63630838
173MP0001697_abnormal_embryo_size0.63166539
174MP0003880_abnormal_central_pattern0.62639085
175MP0002452_abnormal_antigen_presenting0.62581200
176MP0000627_abnormal_mammary_gland0.62444975
177MP0009053_abnormal_anal_canal0.61834230
178MP0003385_abnormal_body_wall0.61598796
179MP0008932_abnormal_embryonic_tissue0.61593355
180MP0002697_abnormal_eye_size0.61464309
181MP0004130_abnormal_muscle_cell0.61108045
182MP0002184_abnormal_innervation0.59299656
183MP0005551_abnormal_eye_electrophysiolog0.58724989
184MP0002733_abnormal_thermal_nociception0.56770338
185MP0005645_abnormal_hypothalamus_physiol0.56452817
186MP0004134_abnormal_chest_morphology0.55026406
187MP0005499_abnormal_olfactory_system0.54946059
188MP0005394_taste/olfaction_phenotype0.54946059
189MP0000778_abnormal_nervous_system0.54576676

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.08384690
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.85736525
3Nemaline bodies (HP:0003798)7.57922271
4Nonprogressive disorder (HP:0003680)7.38255380
5Exercise-induced myalgia (HP:0003738)6.66630154
6Exercise-induced muscle cramps (HP:0003710)6.47436518
7Muscle hypertrophy of the lower extremities (HP:0008968)6.38086037
8Calf muscle hypertrophy (HP:0008981)6.04736724
9Type 1 muscle fiber predominance (HP:0003803)5.88991293
10Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.43412534
11Abnormality of the calf musculature (HP:0001430)5.23306525
12Hyporeflexia of lower limbs (HP:0002600)5.10121285
13EMG: myopathic abnormalities (HP:0003458)4.99668267
14Abnormality of secondary sexual hair (HP:0009888)4.93525352
15Abnormality of the axillary hair (HP:0100134)4.93525352
16Spastic tetraparesis (HP:0001285)4.62723019
17Muscle fiber splitting (HP:0003555)4.54531116
18Sudden death (HP:0001699)4.53001320
19Rimmed vacuoles (HP:0003805)4.51466249
20Myopathic facies (HP:0002058)4.29220984
21Type 2 muscle fiber atrophy (HP:0003554)4.26091944
22Atrioventricular block (HP:0001678)4.20703734
23Progressive inability to walk (HP:0002505)3.98460085
24Myoglobinuria (HP:0002913)3.97788193
25Absent frontal sinuses (HP:0002688)3.91016309
26Abnormality of the neuromuscular junction (HP:0003398)3.85886931
27Fatigable weakness (HP:0003473)3.85886931
28Biconcave vertebral bodies (HP:0004586)3.84871026
29Muscle fiber atrophy (HP:0100295)3.76771928
30Round ear (HP:0100830)3.75813238
31Neck muscle weakness (HP:0000467)3.74906567
32Ulnar claw (HP:0001178)3.67796684
33Peripheral hypomyelination (HP:0007182)3.65874273
34Diastasis recti (HP:0001540)3.53087366
35Spinal cord lesions (HP:0100561)3.52725954
36Syringomyelia (HP:0003396)3.52725954
37Centrally nucleated skeletal muscle fibers (HP:0003687)3.52512879
38Ragged-red muscle fibers (HP:0003200)3.51287154
39Abnormal hemoglobin (HP:0011902)3.51284277
40Rhabdomyolysis (HP:0003201)3.51267509
41Abnormality of the left ventricular outflow tract (HP:0011103)3.47920970
42Subaortic stenosis (HP:0001682)3.47920970
43Difficulty running (HP:0009046)3.45344087
44Frequent falls (HP:0002359)3.42090698
45Abnormal hair laboratory examination (HP:0003328)3.36491484
46Easy fatigability (HP:0003388)3.28591716
47Distal arthrogryposis (HP:0005684)3.26768051
48Abnormality of the frontal sinuses (HP:0002687)3.24378925
49Fragile skin (HP:0001030)3.24189263
50Abnormality of skeletal muscle fiber size (HP:0012084)3.22708004
51Calcaneovalgus deformity (HP:0001848)3.15748077
52Hyperacusis (HP:0010780)3.11504060
53Dysmetric saccades (HP:0000641)3.09299071
54Gaze-evoked nystagmus (HP:0000640)3.08274620
55Ulnar deviation of the wrist (HP:0003049)3.07648016
56Pseudobulbar signs (HP:0002200)3.06293137
57Malignant hyperthermia (HP:0002047)3.02481859
58Myotonia (HP:0002486)3.00444660
59Fetal akinesia sequence (HP:0001989)2.99318726
60Pili torti (HP:0003777)2.98810854
61Increased variability in muscle fiber diameter (HP:0003557)2.96790238
62Gonadotropin excess (HP:0000837)2.94465664
63Absent phalangeal crease (HP:0006109)2.92854484
64Weak cry (HP:0001612)2.90748720
65Late onset (HP:0003584)2.88933541
66Scapular winging (HP:0003691)2.88431743
67Areflexia of lower limbs (HP:0002522)2.81807992
68Dilated cardiomyopathy (HP:0001644)2.79730752
69Selective tooth agenesis (HP:0001592)2.77793046
70Abnormality of the anterior chamber (HP:0000593)2.75631326
71Deformed tarsal bones (HP:0008119)2.73033939
72Abnormality of the shoulder girdle musculature (HP:0001435)2.69497963
73Adactyly (HP:0009776)2.68912357
74Asymmetric septal hypertrophy (HP:0001670)2.68080831
75Muscle stiffness (HP:0003552)2.66862772
76Absent hair (HP:0002298)2.66325693
77Microretrognathia (HP:0000308)2.65701935
78Limb-girdle muscle atrophy (HP:0003797)2.60754508
79EMG: neuropathic changes (HP:0003445)2.60583711
80Proximal amyotrophy (HP:0007126)2.59425193
81Lipoatrophy (HP:0100578)2.58793665
82Ventricular tachycardia (HP:0004756)2.56888424
83Papilledema (HP:0001085)2.55977545
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54402098
85Scanning speech (HP:0002168)2.52805383
86Annular pancreas (HP:0001734)2.51785022
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.49906403
88Absent/shortened dynein arms (HP:0200106)2.49906403
89Increased connective tissue (HP:0009025)2.47645986
90Abnormal atrioventricular conduction (HP:0005150)2.47062648
91Prolonged bleeding time (HP:0003010)2.45278836
92Heart block (HP:0012722)2.44324780
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.40637987
94Generalized muscle weakness (HP:0003324)2.37256649
95Abnormal finger flexion creases (HP:0006143)2.36505257
96Hypoplasia of the iris (HP:0007676)2.33853963
97Hypercholesterolemia (HP:0003124)2.32195988
98Distal lower limb muscle weakness (HP:0009053)2.30520691
99Syncope (HP:0001279)2.29770014
100Rhabdomyosarcoma (HP:0002859)2.29122876
101Bulbar palsy (HP:0001283)2.28879546
102Fatigue (HP:0012378)2.28136873
103Acute myeloid leukemia (HP:0004808)2.28104670
104Bundle branch block (HP:0011710)2.28011747
105Delayed cranial suture closure (HP:0000270)2.27491239
106Depressed nasal tip (HP:0000437)2.25690525
107Ventricular arrhythmia (HP:0004308)2.25277540
108Ventricular fibrillation (HP:0001663)2.25158667
109Abnormality of the foot musculature (HP:0001436)2.24550524
110Muscular dystrophy (HP:0003560)2.24437858
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24380193
112Abnormality of the vocal cords (HP:0008777)2.23448274
113Prostate neoplasm (HP:0100787)2.19033571
114Tented upper lip vermilion (HP:0010804)2.17081964
115Febrile seizures (HP:0002373)2.06892484
116Respiratory insufficiency due to muscle weakness (HP:0002747)2.06636836
117Abnormality of the peritoneum (HP:0002585)2.05969279
118Osteolytic defects of the hand bones (HP:0009699)2.04556395
119Osteolytic defects of the phalanges of the hand (HP:0009771)2.04556395
120Atrial fibrillation (HP:0005110)2.04157406
121Foot dorsiflexor weakness (HP:0009027)2.02566001
122Sparse eyelashes (HP:0000653)2.01561729
123Prolonged QT interval (HP:0001657)1.97068223
124Abnormal lung lobation (HP:0002101)1.96550902
125Long clavicles (HP:0000890)1.95795586
126Synophrys (HP:0000664)1.95061022
127Decreased muscle mass (HP:0003199)1.92927508
128Joint hemorrhage (HP:0005261)1.92811706
129Hip contracture (HP:0003273)1.91867175
130Xanthomatosis (HP:0000991)1.90788843
131Popliteal pterygium (HP:0009756)1.90208664
132Amelogenesis imperfecta (HP:0000705)1.89272631
133Supernumerary ribs (HP:0005815)1.88708464
134Mildly elevated creatine phosphokinase (HP:0008180)1.88609681
135Steppage gait (HP:0003376)1.87199523
136Neonatal onset (HP:0003623)1.86227069
137Difficulty climbing stairs (HP:0003551)1.85548695
138Focal motor seizures (HP:0011153)1.85460809
139Neonatal respiratory distress (HP:0002643)1.83314157
140Primary atrial arrhythmia (HP:0001692)1.83180263
141Abnormality of the hip-girdle musculature (HP:0001445)1.80662390
142Abnormality of the musculature of the pelvis (HP:0001469)1.80662390
143Hypotrichosis (HP:0001006)1.79276896
144Plagiocephaly (HP:0001357)1.78335818
145Right ventricular cardiomyopathy (HP:0011663)1.78160984
146Hyperkalemia (HP:0002153)1.78063865
147Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77533171
148Left ventricular hypertrophy (HP:0001712)1.77449875
149Infertility (HP:0000789)1.76843594
150Bone cyst (HP:0012062)1.76087002
151Abnormality of methionine metabolism (HP:0010901)1.74518483
152Intrahepatic cholestasis (HP:0001406)1.74364681
153Supraventricular tachycardia (HP:0004755)1.74244105
154Abnormality of the parietal bone (HP:0002696)1.73937238
155Split hand (HP:0001171)1.73435996
156Truncal obesity (HP:0001956)1.72112739
157Waddling gait (HP:0002515)1.72043818
158Gowers sign (HP:0003391)1.70402126
159Abnormal EKG (HP:0003115)1.69981318
160Spinal rigidity (HP:0003306)1.69871449
161Supraventricular arrhythmia (HP:0005115)1.69099773
162Abnormality of the phalanges of the hallux (HP:0010057)1.68579905
163Broad-based gait (HP:0002136)1.67355974
164Limb-girdle muscle weakness (HP:0003325)1.67153379
165Generalized tonic-clonic seizures (HP:0002069)1.66807880
166Supernumerary bones of the axial skeleton (HP:0009144)1.66783429
167Shoulder girdle muscle weakness (HP:0003547)1.66540333
168Heterotopia (HP:0002282)1.65073957
169Exercise intolerance (HP:0003546)1.64848061
170Abnormality of the pulmonary veins (HP:0011718)1.64481512
171Focal seizures (HP:0007359)1.62794571
172Woolly hair (HP:0002224)1.62435885
173Neonatal hypoglycemia (HP:0001998)1.62351034
174Stroke (HP:0001297)1.62132700
175Esophageal varix (HP:0002040)1.61017593
176Atonic seizures (HP:0010819)1.60317836
177Smooth philtrum (HP:0000319)1.58681255
178Abnormal number of erythroid precursors (HP:0012131)1.57581983
179Clumsiness (HP:0002312)1.57362766
180Epistaxis (HP:0000421)1.57230006
181Peripheral demyelination (HP:0011096)1.57016908
182Difficulty walking (HP:0002355)1.55983011
183Distal lower limb amyotrophy (HP:0008944)1.54277732
184Facial diplegia (HP:0001349)1.52745849
185Hyperinsulinemic hypoglycemia (HP:0000825)1.52234496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK8.58168548
2OBSCN8.02233963
3PHKG24.99925228
4PHKG14.99925228
5MARK13.11237618
6PRKD32.82420755
7TESK12.74846259
8CDC72.22892941
9SRPK110.0603229
10TESK21.85428064
11MAP3K41.77247156
12FRK1.75677300
13STK381.75621348
14NTRK21.59043687
15CDK121.57426134
16CDK61.57114220
17MAPK121.55138344
18MAP2K71.52180823
19PRKG21.49519573
20PIK3CG1.47344896
21RPS6KA41.45959157
22NME11.44627939
23MAPK131.43782823
24PAK31.39729713
25ICK1.36855153
26TNIK1.31478117
27CLK11.29794996
28MAP3K71.17172493
29TLK11.16993843
30PRKD21.15969903
31MAP2K41.15167355
32ERBB41.13606324
33DYRK1B1.12864209
34MYLK1.10345593
35ALK1.07212460
36STK111.05955203
37MST1R1.04595902
38PIM11.03783869
39SGK4940.99121479
40SGK2230.99121479
41EPHA30.98800505
42PKN10.98467702
43STK38L0.97713020
44WNK30.96808133
45CSNK1G10.94222235
46MOS0.93436815
47SGK20.91897214
48FGFR20.91800031
49BMX0.91541782
50SGK30.91262327
51DMPK0.90968065
52CAMK2A0.87765108
53CASK0.87628278
54ERBB30.87492056
55PAK60.86828867
56CAMK2G0.84761252
57MAP4K20.84380081
58RIPK10.82736441
59TGFBR20.81259307
60CCNB10.81077635
61PRKAA10.79508282
62EIF2AK20.78361831
63NTRK30.78121000
64GRK10.77557370
65PRKG10.77333275
66DYRK20.76789940
67CAMK2D0.75642152
68STK100.75380164
69YES10.75004862
70TIE10.74223594
71MAPKAPK30.74175739
72MET0.73802225
73CAMK2B0.73721429
74MARK30.73371530
75PRKAA20.71914811
76PRKCG0.69038218
77RPS6KA50.68185531
78CAMK10.65914171
79TTN0.65856073
80DAPK20.63311107
81TGFBR10.61378316
82MAP4K10.61268169
83PRKCE0.60951496
84CSNK1G20.59509907
85EPHA40.58754047
86OXSR10.57459453
87MAP2K60.56995931
88NEK20.56549896
89ADRBK20.55812729
90CDK50.55161952
91PRKACA0.54817070
92CAMK40.54562404
93TNK20.52421329
94TXK0.49924405
95PDK40.49121433
96PDK30.49121433
97TAOK10.49094224
98LATS20.48699077
99BMPR1B0.48215981
100CSNK1G30.48041270
101CDK70.47902822
102CAMK1D0.47836308
103GSK3A0.47140948
104GRK60.46533185
105RPS6KB10.46357300
106PIK3CA0.46132498
107TRPM70.45926481
108TEC0.45788061
109MAP3K60.45221738
110ATR0.45197922
111CSK0.45169510
112PRKACB0.45030513
113STK40.44128198
114HIPK20.42576692
115MKNK10.41182351
116STK30.40575831
117BRD40.40240156
118PNCK0.40007467
119INSRR0.39751740
120FGR0.39580986
121ACVR1B0.39554728
122MAP3K140.39406962
123SIK10.39269424
124PDK20.39220676
125RIPK40.38617679
126JAK20.38346101
127MKNK20.37972714
128CSNK2A20.37804699
129LIMK10.37703098
130MAPK100.37537455
131LATS10.37492742
132JAK10.37452876
133RPS6KA30.37379757
134PKN20.37103961
135NME20.37060905
136PAK20.36140757
137AKT30.35827208
138KDR0.35044970
139EGFR0.34663870
140STK390.34494403
141MAP3K110.34470003
142CSNK1A1L0.33868910
143MAP3K50.33478219
144MELK0.31435623
145CDK30.31270984
146MAP3K90.30857549
147IKBKB0.29172984
148ZAK0.28995447
149PRKD10.28619778
150MAPK40.28233355
151MAP2K10.28123606
152MAPK70.28088153
153CSNK1D0.28060608
154SGK10.27686835
155DAPK30.27502474
156NLK0.27111788
157PRKACG0.26745719
158ABL10.26581411
159CHEK20.25801334
160CAMK1G0.25720261
161PDGFRB0.25381033
162AURKB0.25255096
163CSNK2A10.25019522
164INSR0.24705441
165ATM0.24612040
166ROCK10.24581715
167NEK10.24512237
168BUB10.23081387
169CDK90.22832931
170RPS6KA10.21368162
171CHUK0.20841411
172FER0.20827905
173CDK40.19792202
174UHMK10.17709324
175MAPK150.17191254
176AKT20.17040304
177ZAP700.16850899
178CSNK1E0.16747116
179PINK10.16386723

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.53651992
2Caffeine metabolism_Homo sapiens_hsa002324.97616104
3Cardiac muscle contraction_Homo sapiens_hsa042603.99196726
4Nitrogen metabolism_Homo sapiens_hsa009103.83590492
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.60160225
6Dilated cardiomyopathy_Homo sapiens_hsa054143.45241358
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.41984527
8Alcoholism_Homo sapiens_hsa050342.86166015
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63400136
10Circadian rhythm_Homo sapiens_hsa047102.59900367
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.57369826
12Nicotine addiction_Homo sapiens_hsa050332.32300619
13Transcriptional misregulation in cancer_Homo sapiens_hsa052022.29657129
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.15691265
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.05551262
16Parkinsons disease_Homo sapiens_hsa050122.02639251
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.00983738
18Oxidative phosphorylation_Homo sapiens_hsa001901.98179818
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82500932
20Circadian entrainment_Homo sapiens_hsa047131.82004819
21Oxytocin signaling pathway_Homo sapiens_hsa049211.77959127
22Calcium signaling pathway_Homo sapiens_hsa040201.76793402
23Insulin secretion_Homo sapiens_hsa049111.76501130
24Dorso-ventral axis formation_Homo sapiens_hsa043201.69548244
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69015021
26Selenocompound metabolism_Homo sapiens_hsa004501.62622734
27Complement and coagulation cascades_Homo sapiens_hsa046101.61235274
28Alzheimers disease_Homo sapiens_hsa050101.59069801
29GABAergic synapse_Homo sapiens_hsa047271.58028318
30Arginine biosynthesis_Homo sapiens_hsa002201.50487269
31Butanoate metabolism_Homo sapiens_hsa006501.46759175
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.46676536
33Amphetamine addiction_Homo sapiens_hsa050311.42123172
34ABC transporters_Homo sapiens_hsa020101.41722922
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.40112854
36Gastric acid secretion_Homo sapiens_hsa049711.39982891
37Fatty acid biosynthesis_Homo sapiens_hsa000611.39680727
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36325344
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35365948
40RNA transport_Homo sapiens_hsa030131.33863059
41Acute myeloid leukemia_Homo sapiens_hsa052211.32486791
42Viral carcinogenesis_Homo sapiens_hsa052031.28532293
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.26755182
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25464025
45Morphine addiction_Homo sapiens_hsa050321.25214740
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24566516
47Phototransduction_Homo sapiens_hsa047441.24436601
48Arginine and proline metabolism_Homo sapiens_hsa003301.20604619
49Olfactory transduction_Homo sapiens_hsa047401.16674053
50Glutamatergic synapse_Homo sapiens_hsa047241.15570557
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.14678426
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12307869
53Regulation of autophagy_Homo sapiens_hsa041401.12095351
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10201184
55Chemical carcinogenesis_Homo sapiens_hsa052041.10094993
56One carbon pool by folate_Homo sapiens_hsa006701.09981762
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09405964
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.08995349
59Salivary secretion_Homo sapiens_hsa049701.08807312
60Dopaminergic synapse_Homo sapiens_hsa047281.08577510
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05380984
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05130683
63PPAR signaling pathway_Homo sapiens_hsa033201.04791691
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04017056
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02660563
66Staphylococcus aureus infection_Homo sapiens_hsa051501.02512338
67Synaptic vesicle cycle_Homo sapiens_hsa047211.02361625
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02155726
69Insulin signaling pathway_Homo sapiens_hsa049101.02112282
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01915640
71B cell receptor signaling pathway_Homo sapiens_hsa046621.01856391
72Huntingtons disease_Homo sapiens_hsa050160.98098601
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97198178
74cAMP signaling pathway_Homo sapiens_hsa040240.96496106
75Cocaine addiction_Homo sapiens_hsa050300.94481915
76Long-term potentiation_Homo sapiens_hsa047200.93738178
77Taste transduction_Homo sapiens_hsa047420.93507537
78Cholinergic synapse_Homo sapiens_hsa047250.93008744
79Pyruvate metabolism_Homo sapiens_hsa006200.91784470
80Fatty acid degradation_Homo sapiens_hsa000710.91379725
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89835372
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88696094
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87893816
84Bile secretion_Homo sapiens_hsa049760.87768697
85Herpes simplex infection_Homo sapiens_hsa051680.87606180
86Sulfur metabolism_Homo sapiens_hsa009200.87335789
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86134328
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85810338
89Linoleic acid metabolism_Homo sapiens_hsa005910.84560450
90Platelet activation_Homo sapiens_hsa046110.84510865
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84475720
92RNA degradation_Homo sapiens_hsa030180.83903034
93Long-term depression_Homo sapiens_hsa047300.82708126
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82507829
95Vitamin digestion and absorption_Homo sapiens_hsa049770.80303624
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80217474
97beta-Alanine metabolism_Homo sapiens_hsa004100.79901124
98Glycerolipid metabolism_Homo sapiens_hsa005610.77974846
99MicroRNAs in cancer_Homo sapiens_hsa052060.76944415
100Hedgehog signaling pathway_Homo sapiens_hsa043400.75137151
101Thyroid cancer_Homo sapiens_hsa052160.74735653
102Ribosome_Homo sapiens_hsa030100.73946195
103Gap junction_Homo sapiens_hsa045400.73597127
104Glucagon signaling pathway_Homo sapiens_hsa049220.72221693
105Ovarian steroidogenesis_Homo sapiens_hsa049130.70719632
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.70462843
107Measles_Homo sapiens_hsa051620.69357957
108Lysine degradation_Homo sapiens_hsa003100.68112203
109Glutathione metabolism_Homo sapiens_hsa004800.68103546
110Carbon metabolism_Homo sapiens_hsa012000.66864035
111Tight junction_Homo sapiens_hsa045300.65685862
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65346666
113Type II diabetes mellitus_Homo sapiens_hsa049300.64659411
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.63253379
115Malaria_Homo sapiens_hsa051440.63207355
116Tryptophan metabolism_Homo sapiens_hsa003800.62965371
117Collecting duct acid secretion_Homo sapiens_hsa049660.62938771
118Serotonergic synapse_Homo sapiens_hsa047260.60954252
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.59968313
120mRNA surveillance pathway_Homo sapiens_hsa030150.59597692
121Melanogenesis_Homo sapiens_hsa049160.58175789
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57388563
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57006649
124GnRH signaling pathway_Homo sapiens_hsa049120.56921523
125Retinol metabolism_Homo sapiens_hsa008300.55976638
126Peroxisome_Homo sapiens_hsa041460.55651634
127Propanoate metabolism_Homo sapiens_hsa006400.54575113
128Pancreatic secretion_Homo sapiens_hsa049720.54386766
129Osteoclast differentiation_Homo sapiens_hsa043800.51607776
130Basal cell carcinoma_Homo sapiens_hsa052170.50535097
131Fructose and mannose metabolism_Homo sapiens_hsa000510.50306415
132DNA replication_Homo sapiens_hsa030300.49653114
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47933979
134Fatty acid metabolism_Homo sapiens_hsa012120.47707460
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47076863
136Mineral absorption_Homo sapiens_hsa049780.46471097
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46064467
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.45684826
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44522180
140Axon guidance_Homo sapiens_hsa043600.44135736
141Purine metabolism_Homo sapiens_hsa002300.43664721
142Small cell lung cancer_Homo sapiens_hsa052220.43084592
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41917718
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41133625
145Leishmaniasis_Homo sapiens_hsa051400.41111999
146Antigen processing and presentation_Homo sapiens_hsa046120.40586358
147Fat digestion and absorption_Homo sapiens_hsa049750.38723930
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38229876
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37784773
150Prostate cancer_Homo sapiens_hsa052150.36244660
151MAPK signaling pathway_Homo sapiens_hsa040100.36222932
152Inositol phosphate metabolism_Homo sapiens_hsa005620.35782323
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34820909
154Spliceosome_Homo sapiens_hsa030400.34696195
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.33923433
156Proteoglycans in cancer_Homo sapiens_hsa052050.33133447
157Renin secretion_Homo sapiens_hsa049240.31862448
158Chronic myeloid leukemia_Homo sapiens_hsa052200.31794689
159Shigellosis_Homo sapiens_hsa051310.31483474
160Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31148014
161Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30717450
162Starch and sucrose metabolism_Homo sapiens_hsa005000.30266118
163Sulfur relay system_Homo sapiens_hsa041220.29814780
164Cell cycle_Homo sapiens_hsa041100.29230099
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.28902145
166HTLV-I infection_Homo sapiens_hsa051660.27424964
167Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27406562
168Non-small cell lung cancer_Homo sapiens_hsa052230.26584779
169Insulin resistance_Homo sapiens_hsa049310.25485661
170Oocyte meiosis_Homo sapiens_hsa041140.25137257
171AMPK signaling pathway_Homo sapiens_hsa041520.24845154
172Jak-STAT signaling pathway_Homo sapiens_hsa046300.23978550
173Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23712635
174Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23451122
175Focal adhesion_Homo sapiens_hsa045100.23204576
176Wnt signaling pathway_Homo sapiens_hsa043100.22087375
177Steroid hormone biosynthesis_Homo sapiens_hsa001400.21423725

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