GRIPAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.03087827
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.96531050
3locomotory exploration behavior (GO:0035641)4.93258469
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46454069
5positive regulation of gamma-delta T cell activation (GO:0046645)4.31065879
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30555977
7synaptic vesicle exocytosis (GO:0016079)4.30126604
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28343050
9regulation of synaptic vesicle exocytosis (GO:2000300)4.21891131
10regulation of glutamate receptor signaling pathway (GO:1900449)4.17294370
11regulation of synapse structural plasticity (GO:0051823)4.11756930
12vocalization behavior (GO:0071625)4.00828387
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.96472217
14glutamate secretion (GO:0014047)3.96279278
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.92790799
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91675866
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80678253
18regulation of synaptic vesicle transport (GO:1902803)3.76199428
19neuronal action potential propagation (GO:0019227)3.68072346
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63919959
21neurotransmitter secretion (GO:0007269)3.61473026
22regulation of neuronal synaptic plasticity (GO:0048168)3.57790118
23negative regulation of erythrocyte differentiation (GO:0045647)3.56637650
24exploration behavior (GO:0035640)3.48954447
25protein localization to synapse (GO:0035418)3.48770152
26cerebellar Purkinje cell differentiation (GO:0021702)3.48749306
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46328210
28regulation of gamma-delta T cell activation (GO:0046643)3.39716348
29prepulse inhibition (GO:0060134)3.38235354
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37204796
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.37204796
32modulation by symbiont of host immune response (GO:0052553)3.37204796
33positive regulation by symbiont of host defense response (GO:0052509)3.37204796
34modulation by symbiont of host defense response (GO:0052031)3.37204796
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37204796
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.36473376
37synaptic transmission, glutamatergic (GO:0035249)3.34880640
38antigen processing and presentation of endogenous antigen (GO:0019883)3.33992740
39cellular potassium ion homeostasis (GO:0030007)3.33399456
40response to muramyl dipeptide (GO:0032495)3.32090664
41mannose metabolic process (GO:0006013)3.31192893
42glutamate receptor signaling pathway (GO:0007215)3.28636630
43regulation of ARF protein signal transduction (GO:0032012)3.27745812
44neurotransmitter-gated ion channel clustering (GO:0072578)3.27564243
45glycine transport (GO:0015816)3.25711687
46gamma-aminobutyric acid transport (GO:0015812)3.23782922
47synaptic vesicle endocytosis (GO:0048488)3.23475826
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23243566
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21901827
50long-term memory (GO:0007616)3.21185879
51neuron-neuron synaptic transmission (GO:0007270)3.18722665
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15078829
53macrophage activation involved in immune response (GO:0002281)3.14638957
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10587077
55membrane depolarization during action potential (GO:0086010)3.09090917
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07323979
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07229741
58proline transport (GO:0015824)3.06474491
59layer formation in cerebral cortex (GO:0021819)3.04852515
60neuromuscular process controlling balance (GO:0050885)3.03449473
61neuron cell-cell adhesion (GO:0007158)3.02517742
62regulation of gamma-delta T cell differentiation (GO:0045586)3.00715410
63vesicle transport along microtubule (GO:0047496)3.00590563
64regulation of postsynaptic membrane potential (GO:0060078)3.00303419
65sodium ion export (GO:0071436)2.98840786
66long-term synaptic potentiation (GO:0060291)2.96839458
67activation of protein kinase A activity (GO:0034199)2.95642762
68regulation of synaptic plasticity (GO:0048167)2.94187535
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93277554
70germinal center formation (GO:0002467)2.93127926
71positive regulation of membrane potential (GO:0045838)2.91983783
72negative regulation of cell killing (GO:0031342)2.90583428
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90583428
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.90374104
75dendrite morphogenesis (GO:0048813)2.90372075
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90238909
77signal complex assembly (GO:0007172)2.88091126
78negative regulation of lymphocyte mediated immunity (GO:0002707)2.87799814
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87262510
80positive thymic T cell selection (GO:0045059)2.85786688
81leukocyte aggregation (GO:0070486)2.83650381
82auditory behavior (GO:0031223)2.83091849
83regulation of neurotransmitter secretion (GO:0046928)2.83027361
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82906437
85neurotransmitter transport (GO:0006836)2.81734487
86membrane depolarization (GO:0051899)2.81632693
87neuromuscular process controlling posture (GO:0050884)2.80569282
88response to auditory stimulus (GO:0010996)2.79238557
89regulation of Rap GTPase activity (GO:0032317)2.78481213
90positive regulation of CREB transcription factor activity (GO:0032793)2.76931085
91negative regulation of leukocyte mediated immunity (GO:0002704)2.76733142
92positive regulation of Rap GTPase activity (GO:0032854)2.75991440
93regulation of B cell receptor signaling pathway (GO:0050855)2.74344670
94regulation of dendritic spine morphogenesis (GO:0061001)2.73918493
95nerve growth factor signaling pathway (GO:0038180)2.73649661
96transmission of nerve impulse (GO:0019226)2.73157425
97positive regulation of neurotransmitter transport (GO:0051590)2.73014355
98negative thymic T cell selection (GO:0045060)2.72534039
99dendritic spine morphogenesis (GO:0060997)2.72168366
100striatum development (GO:0021756)2.71678583
101B cell receptor signaling pathway (GO:0050853)2.69033207
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68518441
103gamma-aminobutyric acid signaling pathway (GO:0007214)2.68424074
104regulation of neurotransmitter levels (GO:0001505)2.68242343
105regulation of neurotransmitter transport (GO:0051588)2.66875838
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66179924
107regulation of vesicle fusion (GO:0031338)2.65588047
108dopamine receptor signaling pathway (GO:0007212)2.64408651
109positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64299075
110detection of bacterium (GO:0016045)2.64130915
111adult walking behavior (GO:0007628)2.63723630
112regulation of ARF GTPase activity (GO:0032312)2.63699592
113clathrin coat assembly (GO:0048268)2.63300925
114detection of other organism (GO:0098543)2.63034329
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62765339
116activated T cell proliferation (GO:0050798)2.62323437
117neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61971872
118adenosine receptor signaling pathway (GO:0001973)2.61178023
119regulation of regulated secretory pathway (GO:1903305)2.60880497
120regulation of synaptic transmission, GABAergic (GO:0032228)2.60392518
121regulation of voltage-gated calcium channel activity (GO:1901385)2.60022550
122positive regulation of neurotransmitter secretion (GO:0001956)2.59847247
123positive regulation of synaptic transmission (GO:0050806)2.59816232
124negative regulation of T cell mediated immunity (GO:0002710)2.59611057
125neuronal ion channel clustering (GO:0045161)2.57699248
126L-amino acid import (GO:0043092)2.56852529
127cellular extravasation (GO:0045123)2.56407284
128regulation of beta-amyloid formation (GO:1902003)2.56189918
129regulation of interferon-beta biosynthetic process (GO:0045357)2.55745694
130response to interleukin-15 (GO:0070672)2.55084882
131organelle transport along microtubule (GO:0072384)2.53908341
132potassium ion import (GO:0010107)2.53872800
133membrane hyperpolarization (GO:0060081)2.53712594
134response to amphetamine (GO:0001975)2.53405919
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53192376
136negative regulation of interleukin-12 production (GO:0032695)2.52795027
137thymic T cell selection (GO:0045061)2.52729301
138mating behavior (GO:0007617)2.52578699
139response to peptidoglycan (GO:0032494)2.51955650
140cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51801795
141cell migration in hindbrain (GO:0021535)2.51125318
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50877309
143T cell selection (GO:0045058)2.50366740
144regulation of mast cell degranulation (GO:0043304)2.49767800
145T cell migration (GO:0072678)2.49430847
146negative T cell selection (GO:0043383)2.48971629
147positive T cell selection (GO:0043368)2.48913099
148response to type I interferon (GO:0034340)2.48910772
149regulation of leukocyte degranulation (GO:0043300)2.48198072
150cellular response to type I interferon (GO:0071357)2.45719330
151type I interferon signaling pathway (GO:0060337)2.45719330
152interferon-gamma-mediated signaling pathway (GO:0060333)2.43809140
153microglial cell activation (GO:0001774)2.41891079
154regulation of mast cell activation involved in immune response (GO:0033006)2.36661657
155positive regulation of mast cell activation (GO:0033005)2.36509642
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35097387
157response to host immune response (GO:0052572)2.35097387
158establishment of mitochondrion localization (GO:0051654)2.32537030
159NIK/NF-kappaB signaling (GO:0038061)2.32318871
160positive regulation of synapse maturation (GO:0090129)2.32258515
161cerebellar granule cell differentiation (GO:0021707)2.31955742
162tolerance induction (GO:0002507)2.31556729
163positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.30716803
164regulation of T-helper 2 cell differentiation (GO:0045628)2.30055622
165neutrophil activation involved in immune response (GO:0002283)2.29612859
166positive regulation of mast cell activation involved in immune response (GO:0033008)2.29427335
167positive regulation of mast cell degranulation (GO:0043306)2.29427335
168positive regulation of type 2 immune response (GO:0002830)2.28747293
169negative regulation of type 2 immune response (GO:0002829)2.28092841
170macrophage activation (GO:0042116)2.26283207
171positive regulation of B cell differentiation (GO:0045579)2.25398730
172myeloid cell activation involved in immune response (GO:0002275)2.24752152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35719908
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.94001494
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.80159739
4DROSHA_22980978_ChIP-Seq_HELA_Human2.71522056
5GBX2_23144817_ChIP-Seq_PC3_Human2.65590750
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59270624
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.52665363
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50233462
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49727479
10VDR_21846776_ChIP-Seq_THP-1_Human2.48568508
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40280675
12MYC_22102868_ChIP-Seq_BL_Human2.29973618
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28692999
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28374504
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25682351
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24273284
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23146894
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23146894
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.21407785
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16752761
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.09967769
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09566835
23TCF7_22412390_ChIP-Seq_EML_Mouse2.09526119
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08982324
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03650050
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98314610
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92972378
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.91273238
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82890830
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.82147149
31VDR_24763502_ChIP-Seq_THP-1_Human1.78180281
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.77333455
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70409239
34MAF_26560356_Chip-Seq_TH1_Human1.67683061
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67599745
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63053645
37SCL_19346495_ChIP-Seq_HPC-7_Human1.62216953
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61792040
39* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61240361
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.57993101
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57604433
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55448792
43UTX_26944678_Chip-Seq_JUKART_Human1.54455550
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50659267
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.49095608
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48898559
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.48130310
48KDM2B_26808549_Chip-Seq_K562_Human1.46192411
49AR_21572438_ChIP-Seq_LNCaP_Human1.45203248
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.44937102
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44933722
52MAF_26560356_Chip-Seq_TH2_Human1.42870738
53* IRF8_21731497_ChIP-ChIP_J774_Mouse1.41735894
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40503046
55P68_20966046_ChIP-Seq_HELA_Human1.39373600
56SMC4_20622854_ChIP-Seq_HELA_Human1.38948963
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38436203
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36034298
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.34504935
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34093805
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33335491
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30777162
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.29423425
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.29198421
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28875934
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27167405
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25887495
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25686540
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25261119
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22023173
71SMAD4_21799915_ChIP-Seq_A2780_Human1.19649958
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19415622
73OCT4_19829295_ChIP-Seq_ESCs_Human1.17921911
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.17221007
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15835132
76KDM2B_26808549_Chip-Seq_DND41_Human1.15775564
77SPI1_23127762_ChIP-Seq_K562_Human1.15652335
78VDR_24787735_ChIP-Seq_THP-1_Human1.14723449
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14077702
80CREB1_26743006_Chip-Seq_LNCaP_Human1.13742818
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13430086
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.12773245
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12603073
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.12012777
85AR_19668381_ChIP-Seq_PC3_Human1.11806662
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11754528
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.11549945
88BCOR_27268052_Chip-Seq_Bcells_Human1.09447401
89TAF15_26573619_Chip-Seq_HEK293_Human1.09349462
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08109549
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07638115
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06242804
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05628609
94AHR_22903824_ChIP-Seq_MCF-7_Human1.04982884
95BCL6_27268052_Chip-Seq_Bcells_Human1.04826705
96RUNX_20019798_ChIP-Seq_JUKART_Human1.04785853
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04242868
98* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03787753
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03405108
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03383038
101LXR_22292898_ChIP-Seq_THP-1_Human1.00828932
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.00067207
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00055308
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99702581
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99286806
106MYB_26560356_Chip-Seq_TH2_Human0.99224750
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.98639529
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.98369804
109STAT3_23295773_ChIP-Seq_U87_Human0.98190730
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97641528
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.97372105
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.96397069
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95508537
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94716470
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94640742
116CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94621121
117CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94488884
118SA1_27219007_Chip-Seq_Bcells_Human0.94197558
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93854143
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93751265
121RACK7_27058665_Chip-Seq_MCF-7_Human0.92560821
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92272058
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92146707
124AR_25329375_ChIP-Seq_VCAP_Human0.89514082
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88880021
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.88777439
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88343931
128CTCF_27219007_Chip-Seq_Bcells_Human0.88076886
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88072419
130TCF4_23295773_ChIP-Seq_U87_Human0.87366866
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87069808
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86726422
133GATA1_19941826_ChIP-Seq_K562_Human0.85842293
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85608054
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84446641
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83717128
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.82988941
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82841319
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82150788
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.81809498
141P300_19829295_ChIP-Seq_ESCs_Human0.81466549
142SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81356142
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80519574
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.80515389
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79991857
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.79395291
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79100273
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78334766
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78053895
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75945482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02741254
2MP0003635_abnormal_synaptic_transmissio3.74229069
3MP0003880_abnormal_central_pattern3.66123742
4MP0002822_catalepsy3.55249293
5MP0003436_decreased_susceptibility_to3.26608108
6MP0004270_analgesia3.12410318
7MP0009745_abnormal_behavioral_response3.06702952
8MP0002064_seizures3.04801693
9MP0009046_muscle_twitch3.03678779
10MP0002063_abnormal_learning/memory/cond2.93339626
11MP0001968_abnormal_touch/_nociception2.69541815
12MP0000569_abnormal_digit_pigmentation2.59701176
13MP0002572_abnormal_emotion/affect_behav2.49250705
14MP0003724_increased_susceptibility_to2.43809279
15MP0003183_abnormal_peptide_metabolism2.35496947
16MP0002909_abnormal_adrenal_gland2.35458766
17MP0002272_abnormal_nervous_system2.35194666
18MP0002735_abnormal_chemical_nociception2.29880244
19MP0001486_abnormal_startle_reflex2.24021596
20MP0005423_abnormal_somatic_nervous2.21392478
21MP0002734_abnormal_mechanical_nocicepti2.19603749
22MP0001501_abnormal_sleep_pattern2.19563853
23MP0005671_abnormal_response_to2.17356392
24MP0002736_abnormal_nociception_after2.14934267
25MP0008569_lethality_at_weaning2.09035952
26MP0009278_abnormal_bone_marrow2.01087426
27MP0001440_abnormal_grooming_behavior1.95530885
28MP0001970_abnormal_pain_threshold1.92212486
29MP0000685_abnormal_immune_system1.91217963
30MP0002419_abnormal_innate_immunity1.88519045
31MP0002733_abnormal_thermal_nociception1.88279399
32MP0005025_abnormal_response_to1.86162770
33MP0003329_amyloid_beta_deposits1.83376055
34MP0002067_abnormal_sensory_capabilities1.81101402
35MP0002723_abnormal_immune_serum1.78781078
36MP0009780_abnormal_chondrocyte_physiolo1.78486371
37MP0004811_abnormal_neuron_physiology1.75717812
38MP0003172_abnormal_lysosome_physiology1.74053167
39MP0003303_peritoneal_inflammation1.73043489
40MP0008961_abnormal_basal_metabolism1.67980566
41MP0002420_abnormal_adaptive_immunity1.66788622
42MP0001819_abnormal_immune_cell1.64587388
43MP0004858_abnormal_nervous_system1.64256231
44MP0004924_abnormal_behavior1.63252269
45MP0005386_behavior/neurological_phenoty1.63252269
46MP0002452_abnormal_antigen_presenting1.62332178
47MP0003787_abnormal_imprinting1.61108409
48MP0005646_abnormal_pituitary_gland1.57658253
49MP0003763_abnormal_thymus_physiology1.57246914
50MP0004510_myositis1.56337718
51MP0004947_skin_inflammation1.46801985
52MP0002557_abnormal_social/conspecific_i1.46331435
53MP0003633_abnormal_nervous_system1.45499418
54MP0002184_abnormal_innervation1.44714585
55MP0009785_altered_susceptibility_to1.42858723
56MP0000955_abnormal_spinal_cord1.40996305
57MP0000604_amyloidosis1.39647311
58MP0001533_abnormal_skeleton_physiology1.38063335
59MP0000778_abnormal_nervous_system1.36828212
60MP0006082_CNS_inflammation1.35100596
61MP0008260_abnormal_autophagy1.34441469
62MP0002148_abnormal_hypersensitivity_rea1.32251972
63MP0003879_abnormal_hair_cell1.29834808
64MP0000716_abnormal_immune_system1.29830744
65MP0002066_abnormal_motor_capabilities/c1.26488704
66MP0002398_abnormal_bone_marrow1.25698818
67MP0003075_altered_response_to1.23611257
68MP0005645_abnormal_hypothalamus_physiol1.21227980
69MP0002882_abnormal_neuron_morphology1.20574473
70MP0008874_decreased_physiological_sensi1.16285503
71MP0003631_nervous_system_phenotype1.15801866
72MP0003866_abnormal_defecation1.15267320
73MP0003690_abnormal_glial_cell1.14676209
74MP0001502_abnormal_circadian_rhythm1.14414698
75MP0004885_abnormal_endolymph1.13799534
76MP0000920_abnormal_myelination1.12751019
77MP0001984_abnormal_olfaction1.12206888
78MP0001529_abnormal_vocalization1.10889782
79MP0004142_abnormal_muscle_tone1.08596792
80MP0000751_myopathy1.08165223
81MP0006276_abnormal_autonomic_nervous1.07468535
82MP0002229_neurodegeneration1.07255403
83MP0000015_abnormal_ear_pigmentation1.06849956
84MP0003634_abnormal_glial_cell1.06557154
85MP0002405_respiratory_system_inflammati1.06529940
86MP0005535_abnormal_body_temperature1.03177456
87MP0002138_abnormal_hepatobiliary_system1.03024434
88MP0001348_abnormal_lacrimal_gland1.02827935
89MP0010155_abnormal_intestine_physiology1.00562000
90MP0001845_abnormal_inflammatory_respons0.97391525
91MP0000703_abnormal_thymus_morphology0.93584961
92MP0002429_abnormal_blood_cell0.92852404
93MP0010386_abnormal_urinary_bladder0.91900087
94MP0002722_abnormal_immune_system0.91666521
95MP0001905_abnormal_dopamine_level0.91167341
96MP0002653_abnormal_ependyma_morphology0.90514378
97MP0001545_abnormal_hematopoietic_system0.88762406
98MP0005397_hematopoietic_system_phenotyp0.88762406
99MP0002069_abnormal_eating/drinking_beha0.88756911
100MP0004381_abnormal_hair_follicle0.88688466
101MP0000689_abnormal_spleen_morphology0.88328831
102MP0005167_abnormal_blood-brain_barrier0.88046217
103MP0004742_abnormal_vestibular_system0.86841865
104MP0005058_abnormal_lysosome_morphology0.83416524
105MP0002090_abnormal_vision0.83035646
106MP0001873_stomach_inflammation0.82834241
107MP0001986_abnormal_taste_sensitivity0.82741131
108MP0008872_abnormal_physiological_respon0.81870819
109MP0000013_abnormal_adipose_tissue0.81694506
110MP0004085_abnormal_heartbeat0.81533842
111MP0005409_darkened_coat_color0.80864673
112MP0002152_abnormal_brain_morphology0.79472036
113MP0002998_abnormal_bone_remodeling0.78708891
114MP0003632_abnormal_nervous_system0.78463438
115MP0005551_abnormal_eye_electrophysiolog0.73246760
116MP0001790_abnormal_immune_system0.72097826
117MP0005387_immune_system_phenotype0.72097826
118MP0004130_abnormal_muscle_cell0.70859272
119MP0003656_abnormal_erythrocyte_physiolo0.70541322
120MP0005174_abnormal_tail_pigmentation0.70495816
121MP0003300_gastrointestinal_ulcer0.65934372
122MP0002837_dystrophic_cardiac_calcinosis0.64148455
123MP0003122_maternal_imprinting0.63546687
124MP0005464_abnormal_platelet_physiology0.61945532
125MP0005166_decreased_susceptibility_to0.61566436
126MP0005448_abnormal_energy_balance0.59415563
127MP0001188_hyperpigmentation0.58107880
128MP0005310_abnormal_salivary_gland0.57820188
129MP0003283_abnormal_digestive_organ0.57576240
130MP0003045_fibrosis0.56760893
131MP0001800_abnormal_humoral_immune0.55949674
132MP0002638_abnormal_pupillary_reflex0.55586456
133MP0001835_abnormal_antigen_presentation0.53654729
134MP0004043_abnormal_pH_regulation0.53587534
135MP0001664_abnormal_digestion0.52663434
136MP0005000_abnormal_immune_tolerance0.52125377
137MP0002693_abnormal_pancreas_physiology0.51981294

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.75040429
2Focal motor seizures (HP:0011153)5.32887962
3Focal seizures (HP:0007359)4.82633276
4Supranuclear gaze palsy (HP:0000605)4.19234246
5Visual hallucinations (HP:0002367)4.18373253
6Eczematoid dermatitis (HP:0000976)3.90028248
7Atonic seizures (HP:0010819)3.86110448
8Epileptic encephalopathy (HP:0200134)3.82883100
9Febrile seizures (HP:0002373)3.80064252
10Action tremor (HP:0002345)3.76393839
11Progressive cerebellar ataxia (HP:0002073)3.67657340
12Obstructive sleep apnea (HP:0002870)3.41327415
13Ankle clonus (HP:0011448)3.34097069
14Recurrent bacterial skin infections (HP:0005406)3.33598458
15Myositis (HP:0100614)3.29675563
16Depression (HP:0000716)3.28853601
17Absence seizures (HP:0002121)3.27336326
18Truncal ataxia (HP:0002078)3.17830699
19Recurrent abscess formation (HP:0002722)3.17278383
20Dialeptic seizures (HP:0011146)3.15870138
21Abnormality of macrophages (HP:0004311)3.08141020
22Urinary bladder sphincter dysfunction (HP:0002839)3.04895964
23Retrobulbar optic neuritis (HP:0100654)3.02927246
24Optic neuritis (HP:0100653)3.02927246
25Generalized tonic-clonic seizures (HP:0002069)3.01576116
26Orchitis (HP:0100796)3.00933098
27Progressive inability to walk (HP:0002505)3.00320539
28Anxiety (HP:0000739)2.96464778
29Impaired vibration sensation in the lower limbs (HP:0002166)2.92556479
30Gaze-evoked nystagmus (HP:0000640)2.90717106
31Dysmetria (HP:0001310)2.90316710
32Postural instability (HP:0002172)2.86726752
33Peripheral hypomyelination (HP:0007182)2.86200706
34Spastic gait (HP:0002064)2.84518949
35Mediastinal lymphadenopathy (HP:0100721)2.83995003
36Urinary urgency (HP:0000012)2.81490123
37Impaired social interactions (HP:0000735)2.80340696
38Abnormal social behavior (HP:0012433)2.80340696
39Broad-based gait (HP:0002136)2.76517017
40Genetic anticipation (HP:0003743)2.73522927
41Poor eye contact (HP:0000817)2.70157343
42Dysdiadochokinesis (HP:0002075)2.70013629
43Papilledema (HP:0001085)2.68729614
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65777901
45Neuronal loss in central nervous system (HP:0002529)2.58755252
46Meningitis (HP:0001287)2.55301032
47Abnormality of binocular vision (HP:0011514)2.55020843
48Diplopia (HP:0000651)2.55020843
49Recurrent fungal infections (HP:0002841)2.54819981
50Scanning speech (HP:0002168)2.53885875
51Impaired smooth pursuit (HP:0007772)2.45988390
52Recurrent gram-negative bacterial infections (HP:0005420)2.45228401
53Hemiplegia (HP:0002301)2.43194622
54Abnormality of the lower motor neuron (HP:0002366)2.42778699
55Obstructive lung disease (HP:0006536)2.42458108
56Chronic obstructive pulmonary disease (HP:0006510)2.42458108
57Resting tremor (HP:0002322)2.40747933
58Abnormal eating behavior (HP:0100738)2.36837120
59Dysmetric saccades (HP:0000641)2.36324660
60Torticollis (HP:0000473)2.36210088
61Increased IgE level (HP:0003212)2.35735177
62Bradykinesia (HP:0002067)2.34951149
63Episodic fever (HP:0001954)2.34329307
64Neurofibrillary tangles (HP:0002185)2.31743177
65Apathy (HP:0000741)2.31095352
66Vasculitis (HP:0002633)2.30773261
67Stereotypic behavior (HP:0000733)2.30673622
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.27712714
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23329660
70Cellulitis (HP:0100658)2.22604486
71Mutism (HP:0002300)2.22408226
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.21982183
73Excessive salivation (HP:0003781)2.21188203
74Drooling (HP:0002307)2.21188203
75Psychosis (HP:0000709)2.20142531
76Diminished motivation (HP:0000745)2.19624272
77Hemiparesis (HP:0001269)2.19333200
78Chronic mucocutaneous candidiasis (HP:0002728)2.17850669
79Recurrent cutaneous fungal infections (HP:0011370)2.17850669
80Recurrent skin infections (HP:0001581)2.17746711
81Increased cerebral lipofuscin (HP:0011813)2.17489915
82Gastrointestinal infarctions (HP:0005244)2.16654266
83Abnormality of ocular smooth pursuit (HP:0000617)2.16301646
84Abnormal hair whorl (HP:0010721)2.16128037
85Dysostosis multiplex (HP:0000943)2.15230585
86Absent speech (HP:0001344)2.15093908
87Lower limb amyotrophy (HP:0007210)2.14651964
88Elevated erythrocyte sedimentation rate (HP:0003565)2.14522253
89Cerebral inclusion bodies (HP:0100314)2.14500868
90Abnormality of liposaccharide metabolism (HP:0010968)2.14436337
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.14436337
92Abnormality of glycolipid metabolism (HP:0010969)2.14436337
93Abnormality of saccadic eye movements (HP:0000570)2.14190299
94Abnormality of the corticospinal tract (HP:0002492)2.13661587
95Slow saccadic eye movements (HP:0000514)2.12371125
96Macroorchidism (HP:0000053)2.12044654
97Hyperventilation (HP:0002883)2.11668695
98Lower limb muscle weakness (HP:0007340)2.10667590
99Focal dystonia (HP:0004373)2.10449883
100Abnormality of the fingertips (HP:0001211)2.09477280
101Global brain atrophy (HP:0002283)2.09399708
102Segmental peripheral demyelination/remyelination (HP:0003481)2.09243677
103Amyloidosis (HP:0011034)2.08719931
104Intention tremor (HP:0002080)2.08329346
105Prolonged bleeding time (HP:0003010)2.06390445
106Gingivitis (HP:0000230)2.05790873
107Spinal canal stenosis (HP:0003416)2.05486960
108Pointed chin (HP:0000307)2.05431833
109Recurrent sinusitis (HP:0011108)2.04571748
110Memory impairment (HP:0002354)2.03631488
111Encephalitis (HP:0002383)2.03263945
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.02881883
113Amblyopia (HP:0000646)2.02480139
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02182867
115Agitation (HP:0000713)2.01056377
116Status epilepticus (HP:0002133)2.00047054
117Epileptiform EEG discharges (HP:0011182)1.99352123
118Gastrointestinal stroma tumor (HP:0100723)1.98292544
119Loss of speech (HP:0002371)1.98248997
120EEG with generalized epileptiform discharges (HP:0011198)1.97626709
121Insomnia (HP:0100785)1.97503814
122Impaired vibratory sensation (HP:0002495)1.96922063
123Onion bulb formation (HP:0003383)1.96844656
124Agammaglobulinemia (HP:0004432)1.96472230
125Rigidity (HP:0002063)1.96421980
126Hemoptysis (HP:0002105)1.95904344
127Insidious onset (HP:0003587)1.95560925
128Termporal pattern (HP:0011008)1.95560925
129Colitis (HP:0002583)1.95470286
130Inability to walk (HP:0002540)1.95424032
131Iris hypopigmentation (HP:0007730)1.94891628
132Stomatitis (HP:0010280)1.92962506
133Pheochromocytoma (HP:0002666)1.92751257
134Chest pain (HP:0100749)1.92054742
135Spontaneous hematomas (HP:0007420)1.90704277
136Ventricular fibrillation (HP:0001663)1.89891845
137Blue irides (HP:0000635)1.89887012
138Panhypogammaglobulinemia (HP:0003139)1.88585261
139Limb dystonia (HP:0002451)1.88194981
140Craniofacial dystonia (HP:0012179)1.88166134
141Hypsarrhythmia (HP:0002521)1.88016527
142Postural tremor (HP:0002174)1.87886327
143Keratoconjunctivitis sicca (HP:0001097)1.85249663
144Failure to thrive in infancy (HP:0001531)1.84764886
145Pulmonary infiltrates (HP:0002113)1.84054428
146Hyperacusis (HP:0010780)1.83919823
147Annular pancreas (HP:0001734)1.83770547
148Vertebral arch anomaly (HP:0008438)1.83220269
149Clonus (HP:0002169)1.82308903
150Hemorrhage of the eye (HP:0011885)1.81118782
151Pulmonary embolism (HP:0002204)1.80878781
152Generalized hypotonia (HP:0001290)1.80624217
153Recurrent viral infections (HP:0004429)1.80280361
154Megalencephaly (HP:0001355)1.79869531
155Rapidly progressive (HP:0003678)1.79196013
156Gastrointestinal inflammation (HP:0004386)1.74157050
157Chronic otitis media (HP:0000389)1.72967812
158Personality changes (HP:0000751)1.72760524
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72175489
160Abnormality of polysaccharide metabolism (HP:0011012)1.72175489
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72175489
162Disinhibition (HP:0000734)1.71512071
163Pustule (HP:0200039)1.71416863
164Sleep apnea (HP:0010535)1.71270296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.70820901
2EPHA43.64350117
3MAP3K93.00126574
4DAPK22.85613602
5RIPK42.81362248
6SIK22.51363812
7MAP3K42.43679043
8TRIB32.23537058
9MARK12.16388832
10MAP3K132.10650661
11FES2.07314057
12MINK12.01611306
13PAK62.00811598
14MAP2K71.90824478
15CDK121.89338247
16CAMKK11.71262997
17SIK31.69791359
18NTRK21.66676317
19NTRK11.61327199
20KSR21.60193738
21CDK51.53780015
22DAPK11.46564402
23PRKD31.45556495
24PRKCH1.43923725
25PRPF4B1.43373891
26TYK21.40428930
27MAP2K41.38647965
28BLK1.35062026
29UHMK11.34023059
30SGK31.33197128
31SGK4941.28353307
32SGK2231.28353307
33MAP4K11.24174672
34CAMK1G1.23410314
35SGK21.20255499
36IRAK41.19925639
37TBK11.19304511
38CAMKK21.18835209
39TNK21.17322130
40ICK1.16469066
41GRK51.14872989
42MAP3K111.11514294
43CSK1.08043854
44FGFR41.07998838
45MARK21.07268083
46ZAP701.05629282
47TAOK11.02884391
48MAP3K20.98118716
49SIK10.97354334
50MAP3K120.96398120
51BTK0.96264424
52TYRO30.95846124
53TNIK0.95392318
54MAPK130.91700358
55JAK10.91593583
56KSR10.91394361
57JAK30.90833535
58TXK0.90339319
59STK380.88400190
60MAPK120.86017229
61CASK0.85937303
62SYK0.85164976
63ALK0.84202887
64RET0.83742988
65PRKCG0.82585994
66CAMK10.82463275
67MAP3K70.80056747
68WNK10.79909126
69MATK0.79564325
70SGK10.79187434
71CSF1R0.78785374
72PDK10.77990958
73PDPK10.74539478
74FGR0.74388289
75MAP3K10.74350307
76HCK0.74223446
77EPHB10.73334607
78LCK0.72430105
79PHKG10.70416608
80PHKG20.70416608
81FGFR30.69470737
82CDC42BPA0.68929783
83PTK2B0.68725626
84NEK60.68024507
85CAMK40.68020840
86FYN0.67066942
87DYRK1B0.66832177
88MAP2K60.64584993
89LYN0.64165128
90STK110.63829347
91MAP2K30.63299435
92INSRR0.62855354
93TAOK20.61415869
94HIPK20.60830880
95CDK180.59360058
96TAOK30.58750041
97CAMK1D0.58702436
98MAP2K20.55951098
99CDK150.55873454
100PLK20.55735184
101CDK190.55581123
102RIPK10.55486762
103ARAF0.54138436
104RPS6KA20.53812368
105LMTK20.53300698
106RPS6KA30.53219017
107MAPK100.53177545
108ERN10.52739070
109PKN10.52381861
110PRKD20.52271021
111DYRK1A0.52117838
112CAMK2A0.51857397
113EPHA30.51780371
114EEF2K0.50599926
115PRKCZ0.50208837
116IKBKB0.50082538
117ITK0.49838939
118CDK11A0.49769914
119PRKD10.49505006
120SMG10.49222647
121PRKCQ0.48025336
122CDK140.47819158
123CAMK2B0.46891632
124DAPK30.46527848
125GRK60.46148013
126IRAK30.45839234
127JAK20.45489136
128CSNK1G20.44347795
129IKBKE0.44214285
130BMPR20.44132874
131PINK10.43183185
132MAPK70.43017413
133GRK70.42368252
134MAP3K140.41182840

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.94549939
2Olfactory transduction_Homo sapiens_hsa047402.58377113
3Nicotine addiction_Homo sapiens_hsa050332.58303884
4GABAergic synapse_Homo sapiens_hsa047272.34182349
5Morphine addiction_Homo sapiens_hsa050322.30717667
6Circadian entrainment_Homo sapiens_hsa047132.30010307
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15699427
8Glutamatergic synapse_Homo sapiens_hsa047242.14020596
9Long-term potentiation_Homo sapiens_hsa047202.07379661
10Amphetamine addiction_Homo sapiens_hsa050311.92625309
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91117365
12Insulin secretion_Homo sapiens_hsa049111.89015419
13Dopaminergic synapse_Homo sapiens_hsa047281.85861184
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83279196
15Cholinergic synapse_Homo sapiens_hsa047251.83164479
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79200775
17Salivary secretion_Homo sapiens_hsa049701.77657806
18Type II diabetes mellitus_Homo sapiens_hsa049301.74438201
19Cocaine addiction_Homo sapiens_hsa050301.67516980
20Leishmaniasis_Homo sapiens_hsa051401.60707208
21Renin secretion_Homo sapiens_hsa049241.58108781
22Gastric acid secretion_Homo sapiens_hsa049711.57224581
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46076951
24Acute myeloid leukemia_Homo sapiens_hsa052211.46023882
25Taste transduction_Homo sapiens_hsa047421.44439594
26Collecting duct acid secretion_Homo sapiens_hsa049661.44312519
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42419495
28Oxytocin signaling pathway_Homo sapiens_hsa049211.41840753
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36929893
30Long-term depression_Homo sapiens_hsa047301.35946679
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35131414
32Calcium signaling pathway_Homo sapiens_hsa040201.32001867
33Serotonergic synapse_Homo sapiens_hsa047261.26593911
34GnRH signaling pathway_Homo sapiens_hsa049121.26278755
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25130879
36B cell receptor signaling pathway_Homo sapiens_hsa046621.21119351
37Primary immunodeficiency_Homo sapiens_hsa053401.19754511
38Staphylococcus aureus infection_Homo sapiens_hsa051501.17823406
39Allograft rejection_Homo sapiens_hsa053301.17497981
40cAMP signaling pathway_Homo sapiens_hsa040241.15642073
41Graft-versus-host disease_Homo sapiens_hsa053321.15336445
42Other glycan degradation_Homo sapiens_hsa005111.15238834
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.14993089
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13146777
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.11711713
46Gap junction_Homo sapiens_hsa045401.10236253
47Glioma_Homo sapiens_hsa052141.09264479
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.06537955
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05491164
50Autoimmune thyroid disease_Homo sapiens_hsa053201.04926704
51ErbB signaling pathway_Homo sapiens_hsa040121.04758859
52TNF signaling pathway_Homo sapiens_hsa046681.03268505
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02544129
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01401299
55Influenza A_Homo sapiens_hsa051641.00780590
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99396429
57Estrogen signaling pathway_Homo sapiens_hsa049150.99311962
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97897146
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95088752
60Asthma_Homo sapiens_hsa053100.95082089
61Chemokine signaling pathway_Homo sapiens_hsa040620.93947675
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93571931
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.91888637
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89747069
65Toxoplasmosis_Homo sapiens_hsa051450.89455491
66Hepatitis C_Homo sapiens_hsa051600.89315308
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85560021
68Notch signaling pathway_Homo sapiens_hsa043300.84917761
69Dorso-ventral axis formation_Homo sapiens_hsa043200.84439931
70Pancreatic secretion_Homo sapiens_hsa049720.82885889
71Vibrio cholerae infection_Homo sapiens_hsa051100.82641819
72Measles_Homo sapiens_hsa051620.80424349
73MAPK signaling pathway_Homo sapiens_hsa040100.80248502
74VEGF signaling pathway_Homo sapiens_hsa043700.78382678
75Osteoclast differentiation_Homo sapiens_hsa043800.78233881
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77869390
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77558438
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.77219098
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76362578
80Non-small cell lung cancer_Homo sapiens_hsa052230.75793428
81T cell receptor signaling pathway_Homo sapiens_hsa046600.75405638
82Endocytosis_Homo sapiens_hsa041440.75289737
83Hepatitis B_Homo sapiens_hsa051610.74949658
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.74466451
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.74213843
86Phototransduction_Homo sapiens_hsa047440.72870380
87Choline metabolism in cancer_Homo sapiens_hsa052310.72453058
88Inositol phosphate metabolism_Homo sapiens_hsa005620.69540834
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69247496
90Pancreatic cancer_Homo sapiens_hsa052120.68140208
91Axon guidance_Homo sapiens_hsa043600.67055152
92Herpes simplex infection_Homo sapiens_hsa051680.65905279
93Type I diabetes mellitus_Homo sapiens_hsa049400.65678680
94mTOR signaling pathway_Homo sapiens_hsa041500.64988269
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64813126
96Prion diseases_Homo sapiens_hsa050200.64274487
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63912449
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61909893
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.61174391
100Prolactin signaling pathway_Homo sapiens_hsa049170.59990653
101Thyroid hormone synthesis_Homo sapiens_hsa049180.59218454
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59024854
103Dilated cardiomyopathy_Homo sapiens_hsa054140.58555565
104Renal cell carcinoma_Homo sapiens_hsa052110.57761707
105Tuberculosis_Homo sapiens_hsa051520.57589447
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56548511
107Melanogenesis_Homo sapiens_hsa049160.56086653
108Lysosome_Homo sapiens_hsa041420.56016113
109Insulin signaling pathway_Homo sapiens_hsa049100.54784522
110Platelet activation_Homo sapiens_hsa046110.54468361
111Rap1 signaling pathway_Homo sapiens_hsa040150.53668824
112Ras signaling pathway_Homo sapiens_hsa040140.51647071
113Glucagon signaling pathway_Homo sapiens_hsa049220.51587221
114Endometrial cancer_Homo sapiens_hsa052130.50797570
115Nitrogen metabolism_Homo sapiens_hsa009100.49508783
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49375912
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49098251
118Chronic myeloid leukemia_Homo sapiens_hsa052200.47161055
119Rheumatoid arthritis_Homo sapiens_hsa053230.43504102
120Insulin resistance_Homo sapiens_hsa049310.42942283
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42662149
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41524343
123Phagosome_Homo sapiens_hsa041450.40499438
124African trypanosomiasis_Homo sapiens_hsa051430.40030261
125Salmonella infection_Homo sapiens_hsa051320.39879139
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39687968
127Bile secretion_Homo sapiens_hsa049760.38932479
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38909143

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