GRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell development (GO:0042461)9.55860226
2eye photoreceptor cell development (GO:0042462)9.12009132
3detection of light stimulus involved in sensory perception (GO:0050962)8.97216229
4detection of light stimulus involved in visual perception (GO:0050908)8.97216229
5* phototransduction, visible light (GO:0007603)8.28316096
6* phototransduction (GO:0007602)8.26052372
7* detection of visible light (GO:0009584)7.94791469
8* detection of light stimulus (GO:0009583)7.83477532
9retinal rod cell development (GO:0046548)7.75557602
10protein-chromophore linkage (GO:0018298)7.74780609
11GMP metabolic process (GO:0046037)7.18812843
12* visual perception (GO:0007601)7.09777047
13* sensory perception of light stimulus (GO:0050953)7.03276207
14positive regulation of guanylate cyclase activity (GO:0031284)6.59333247
15photoreceptor cell differentiation (GO:0046530)6.52055366
16eye photoreceptor cell differentiation (GO:0001754)6.52055366
17regulation of guanylate cyclase activity (GO:0031282)5.86723414
18* detection of external stimulus (GO:0009581)5.67875593
19* detection of abiotic stimulus (GO:0009582)5.58473159
20* cellular response to light stimulus (GO:0071482)5.56830040
21positive regulation of CREB transcription factor activity (GO:0032793)5.41510938
22retina development in camera-type eye (GO:0060041)5.24519649
23cerebellar granule cell differentiation (GO:0021707)5.11607143
24response to pheromone (GO:0019236)4.70504048
25retina layer formation (GO:0010842)4.60002680
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.57196615
27regulation of cGMP metabolic process (GO:0030823)4.48368803
28iron ion import (GO:0097286)4.41965156
29nonmotile primary cilium assembly (GO:0035058)4.40713965
30peptidyl-lysine dimethylation (GO:0018027)4.33667231
31spinal cord development (GO:0021510)4.30242290
32righting reflex (GO:0060013)4.26438199
33detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.23980857
34negative regulation of cytosolic calcium ion concentration (GO:0051481)4.23757963
35ventricular septum morphogenesis (GO:0060412)4.22963306
36ganglion development (GO:0061548)4.09670598
37gamma-aminobutyric acid transport (GO:0015812)4.05999014
38biotin metabolic process (GO:0006768)3.98623163
39positive regulation of cGMP biosynthetic process (GO:0030828)3.96338076
40collecting duct development (GO:0072044)3.94550573
41alpha-linolenic acid metabolic process (GO:0036109)3.92597911
42cerebellar Purkinje cell layer development (GO:0021680)3.91737542
43short-term memory (GO:0007614)3.85102657
44beta-amyloid metabolic process (GO:0050435)3.85013019
45adaptation of signaling pathway (GO:0023058)3.84439118
46prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.79651706
47* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.73700164
48branching involved in prostate gland morphogenesis (GO:0060442)3.73136708
49* cellular response to radiation (GO:0071478)3.72018944
50cell differentiation in hindbrain (GO:0021533)3.67648227
51regulation of cGMP biosynthetic process (GO:0030826)3.66576243
52* sensory perception (GO:0007600)3.65270408
53regulation of memory T cell differentiation (GO:0043380)3.64379638
54folic acid metabolic process (GO:0046655)3.59430145
55gonadal mesoderm development (GO:0007506)3.57933416
56positive regulation of cGMP metabolic process (GO:0030825)3.56882610
57regulation of timing of cell differentiation (GO:0048505)3.55206215
58multicellular organismal movement (GO:0050879)3.55039180
59musculoskeletal movement (GO:0050881)3.55039180
60epithelial cell maturation (GO:0002070)3.49820582
61oogenesis (GO:0048477)3.46328030
62embryonic retina morphogenesis in camera-type eye (GO:0060059)3.44848936
63regulation of development, heterochronic (GO:0040034)3.44553219
64short-chain fatty acid metabolic process (GO:0046459)3.44140964
65regulation of female gonad development (GO:2000194)3.43788968
66cellular anion homeostasis (GO:0030002)3.43510399
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42809662
68estrogen biosynthetic process (GO:0006703)3.38265464
69startle response (GO:0001964)3.38030518
70positive regulation of cell cycle checkpoint (GO:1901978)3.36755122
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.33999512
72receptor guanylyl cyclase signaling pathway (GO:0007168)3.28833565
73protein localization to synapse (GO:0035418)3.28380050
74DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.28105519
75cellular response to electrical stimulus (GO:0071257)3.26878745
76homocysteine metabolic process (GO:0050667)3.21585000
77positive regulation of histone deacetylation (GO:0031065)3.20725691
78positive regulation of synapse maturation (GO:0090129)3.20140694
79folic acid-containing compound metabolic process (GO:0006760)3.19988216
80neuron development (GO:0048666)3.19845562
81positive regulation of male gonad development (GO:2000020)3.19410979
82histone H3-K9 modification (GO:0061647)3.19143719
83histone H3-K9 methylation (GO:0051567)3.17383418
84negative regulation of DNA-templated transcription, elongation (GO:0032785)3.16684291
85L-serine metabolic process (GO:0006563)3.15329174
86face development (GO:0060324)3.13791088
87regulation of sarcomere organization (GO:0060297)3.13039044
88synapse assembly (GO:0007416)3.12844460
89axonal fasciculation (GO:0007413)3.11875885
90regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07897939
91DNA damage response, signal transduction resulting in transcription (GO:0042772)3.06986088
92negative regulation of Rho protein signal transduction (GO:0035024)3.06270410
93cellular response to ATP (GO:0071318)3.05114180
94negative regulation of T-helper cell differentiation (GO:0045623)3.04141790
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04141790
96chemosensory behavior (GO:0007635)3.02563366
97negative regulation of smooth muscle cell differentiation (GO:0051151)3.01689061
98neural tube development (GO:0021915)2.99111369
99negative regulation of hormone biosynthetic process (GO:0032353)2.98936454
100detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.98182846
101regulation of voltage-gated calcium channel activity (GO:1901385)2.97829356
102protein heterotetramerization (GO:0051290)2.95459353
103mechanosensory behavior (GO:0007638)2.92376149
104neuroblast proliferation (GO:0007405)2.91051660
105regulation of gene silencing by RNA (GO:0060966)2.89852633
106regulation of posttranscriptional gene silencing (GO:0060147)2.89852633
107regulation of gene silencing by miRNA (GO:0060964)2.89852633
108negative regulation of gene silencing (GO:0060969)2.89758702
109* response to light stimulus (GO:0009416)2.89688638
110neuron recognition (GO:0008038)2.89278436
111regulation of glycogen (starch) synthase activity (GO:2000465)2.85156571
112regulation of mitotic spindle organization (GO:0060236)2.84712648
113regulation of clathrin-mediated endocytosis (GO:2000369)2.83646383
114forebrain neuron development (GO:0021884)2.83493588
115positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.83339512
116transmission of nerve impulse (GO:0019226)2.83142238
117protein prenylation (GO:0018342)2.82519307
118prenylation (GO:0097354)2.82519307
119positive regulation of protein deacetylation (GO:0090312)2.82096744
120negative regulation of immunoglobulin mediated immune response (GO:0002890)2.81801296
121negative regulation of B cell mediated immunity (GO:0002713)2.81801296
122membrane hyperpolarization (GO:0060081)2.81649173
123serine family amino acid catabolic process (GO:0009071)2.79038115
124behavioral response to ethanol (GO:0048149)2.78880428
125folic acid-containing compound biosynthetic process (GO:0009396)2.78088181
126ectodermal placode formation (GO:0060788)2.77926589
127regulation of germinal center formation (GO:0002634)2.76929815
128detection of chemical stimulus involved in sensory perception (GO:0050907)2.75760517
129regulation of histone deacetylation (GO:0031063)2.75534463
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.74807350
131auditory receptor cell stereocilium organization (GO:0060088)2.73362858
132calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.72839284
133axoneme assembly (GO:0035082)2.71470711
134neuron cell-cell adhesion (GO:0007158)2.70962234
135histone lysine methylation (GO:0034968)2.69647854
136negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68841596
137sensory perception of smell (GO:0007608)2.68821040
138regulation of synapse maturation (GO:0090128)2.68226078
139response to caffeine (GO:0031000)2.68111021
140lung epithelial cell differentiation (GO:0060487)2.66659433
141regulation of translational fidelity (GO:0006450)2.65509770
142regulation of collateral sprouting (GO:0048670)2.64239181
143pseudouridine synthesis (GO:0001522)2.63975975
144regulation of male gonad development (GO:2000018)2.60771798
145diaphragm development (GO:0060539)2.60608080
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59715845
147inner cell mass cell proliferation (GO:0001833)2.59567347
148histone H2B ubiquitination (GO:0033523)2.58742408
149neurotransmitter metabolic process (GO:0042133)2.58187053
150inner ear receptor stereocilium organization (GO:0060122)2.57794731
151very-low-density lipoprotein particle assembly (GO:0034379)2.56868585
152acetyl-CoA metabolic process (GO:0006084)2.55576521
153reflex (GO:0060004)2.55084797
154lung cell differentiation (GO:0060479)2.53756443
155regulation of T-helper 2 cell differentiation (GO:0045628)2.53548764
156positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.53396622
157neuron fate specification (GO:0048665)2.52553219
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52512620
159response to folic acid (GO:0051593)2.52255364
160glandular epithelial cell differentiation (GO:0002067)2.52036503
161positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51542408
162retinoid metabolic process (GO:0001523)2.49699285
163import into cell (GO:0098657)2.43473477
164positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.42776402
165positive regulation of neurotransmitter transport (GO:0051590)2.39837303
166retina homeostasis (GO:0001895)2.39823019
167response to histamine (GO:0034776)2.39594225
168regulation of penile erection (GO:0060405)2.35472482
169regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.35455242
170regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.35455242
171germinal center formation (GO:0002467)2.34437903
172diterpenoid metabolic process (GO:0016101)2.34363862
173L-amino acid import (GO:0043092)2.32585993
174positive regulation of ERBB signaling pathway (GO:1901186)2.28649990
175G-protein coupled receptor internalization (GO:0002031)2.28346117
176histone H3-K4 trimethylation (GO:0080182)2.26642380
177inner ear receptor cell differentiation (GO:0060113)2.26450614
178regulation of mRNA 3-end processing (GO:0031440)2.25292876
179cranial nerve morphogenesis (GO:0021602)2.24864120
180retinol metabolic process (GO:0042572)2.23325288
181adenosine metabolic process (GO:0046085)2.22519139
182icosanoid secretion (GO:0032309)2.21400297
183arachidonic acid secretion (GO:0050482)2.21400297
184calcium ion import (GO:0070509)2.20567411
185* regulation of rhodopsin mediated signaling pathway (GO:0022400)13.9518912
186* rhodopsin mediated signaling pathway (GO:0016056)13.7613870
187retinal cone cell development (GO:0046549)11.5610829
188photoreceptor cell maintenance (GO:0045494)10.3776752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.62719108
2EZH2_22144423_ChIP-Seq_EOC_Human2.68912870
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.65641633
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.65641633
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.65641633
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55911431
7* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.42702808
8VDR_22108803_ChIP-Seq_LS180_Human2.22170586
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17310254
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14290898
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13802189
12AR_21572438_ChIP-Seq_LNCaP_Human2.09055641
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06345199
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05667901
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.03157490
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02407481
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01966563
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01851033
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.99536431
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98929879
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97771034
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97478790
23DROSHA_22980978_ChIP-Seq_HELA_Human1.94289045
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93515800
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.93099664
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.92380149
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.89978355
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88330365
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86791599
30NFE2_27457419_Chip-Seq_LIVER_Mouse1.86471149
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85854436
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85854436
33IGF1R_20145208_ChIP-Seq_DFB_Human1.84494492
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.83624867
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83417349
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80764407
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80203522
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76786482
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71912721
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69716064
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68535821
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66504508
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.66421157
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66254938
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65795525
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65427350
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65027483
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.62030429
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.60586434
50CREB1_26743006_Chip-Seq_LNCaP_Human1.60394483
51P300_19829295_ChIP-Seq_ESCs_Human1.57682211
52CHD1_26751641_Chip-Seq_LNCaP_Human1.56334844
53SMAD4_21799915_ChIP-Seq_A2780_Human1.56156635
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55766756
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.53721814
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53587403
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.49603594
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.47986404
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47271741
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45832075
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45392853
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.44420390
63P53_22387025_ChIP-Seq_ESCs_Mouse1.42529528
64RNF2_27304074_Chip-Seq_NSC_Mouse1.42496180
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.41603131
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39819236
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39635268
68EWS_26573619_Chip-Seq_HEK293_Human1.38402639
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38223685
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.37868168
71P300_18555785_Chip-Seq_ESCs_Mouse1.37838385
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.37167834
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33858135
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33192184
75REST_21632747_ChIP-Seq_MESCs_Mouse1.33180985
76SCL_19346495_ChIP-Seq_HPC-7_Human1.32878735
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32048941
78TAF15_26573619_Chip-Seq_HEK293_Human1.30083348
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28665845
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.28193625
81STAT3_23295773_ChIP-Seq_U87_Human1.27825265
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27564830
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27120836
84ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26772943
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26771136
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.26420013
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.26281332
88SMC4_20622854_ChIP-Seq_HELA_Human1.25795885
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.25570782
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.24852859
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.24231536
92TBL1_22424771_ChIP-Seq_293T_Human1.23976462
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23961914
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.23918285
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23844171
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23199180
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23184978
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.21667508
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21523633
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20998430
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20251536
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20242420
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18722241
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.18428919
105* CTCF_27219007_Chip-Seq_Bcells_Human1.17737975
106CTCF_18555785_Chip-Seq_ESCs_Mouse1.17532339
107PU1_27457419_Chip-Seq_LIVER_Mouse1.16840012
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16462580
109RXR_22108803_ChIP-Seq_LS180_Human1.15883862
110* REST_18959480_ChIP-ChIP_MESCs_Mouse1.15605143
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14242983
112OCT4_19829295_ChIP-Seq_ESCs_Human1.14036383
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13132712
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13111697
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12835812
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.10981881
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10699662
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10036578
119ER_23166858_ChIP-Seq_MCF-7_Human1.10009056
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.09913128
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09908459
122KDM2B_26808549_Chip-Seq_REH_Human1.09454915
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09319869
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09246821
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09218423
126RUNX2_22187159_ChIP-Seq_PCA_Human1.08957054
127TCF4_23295773_ChIP-Seq_U87_Human1.08866595
128E2F1_20622854_ChIP-Seq_HELA_Human1.08261870
129BP1_19119308_ChIP-ChIP_Hs578T_Human1.06314114
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05492079
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.05255144
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.05204262
133RARB_27405468_Chip-Seq_BRAIN_Mouse1.05019653
134AR_19668381_ChIP-Seq_PC3_Human1.04588249
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03541012
136P68_20966046_ChIP-Seq_HELA_Human1.03468781
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02741665
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02639222
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02189601
140MYC_22102868_ChIP-Seq_BL_Human1.00179460
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99608355
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98523341
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98436230
144KDM2B_26808549_Chip-Seq_K562_Human0.96333021
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93832657
146AR_21909140_ChIP-Seq_LNCAP_Human0.92598356
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.92526211
148LXR_22292898_ChIP-Seq_THP-1_Human0.92032786
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87086554
150VDR_21846776_ChIP-Seq_THP-1_Human0.86882067
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85708526
152PHF8_20622854_ChIP-Seq_HELA_Human0.83326893
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.82955490
154AHR_22903824_ChIP-Seq_MCF-7_Human0.82055262
155RAC3_21632823_ChIP-Seq_H3396_Human0.81489417
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79886589
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.77833405
158AR_25329375_ChIP-Seq_VCAP_Human0.77768016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog8.48983111
2* MP0005253_abnormal_eye_physiology5.86610940
3* MP0006072_abnormal_retinal_apoptosis5.13940947
4MP0004858_abnormal_nervous_system5.11960546
5MP0002822_catalepsy4.78741477
6* MP0005195_abnormal_posterior_eye3.35102149
7MP0003950_abnormal_plasma_membrane3.31036580
8MP0001324_abnormal_eye_pigmentation3.10974753
9* MP0005391_vision/eye_phenotype2.87154484
10MP0005423_abnormal_somatic_nervous2.71127099
11MP0005670_abnormal_white_adipose2.67460458
12MP0002090_abnormal_vision2.65648435
13MP0002638_abnormal_pupillary_reflex2.58399967
14MP0003890_abnormal_embryonic-extraembry2.42179257
15MP0003646_muscle_fatigue2.29739129
16MP0004145_abnormal_muscle_electrophysio2.27608966
17MP0001986_abnormal_taste_sensitivity2.25375719
18MP0002102_abnormal_ear_morphology2.20434169
19* MP0002229_neurodegeneration2.19706511
20MP0003879_abnormal_hair_cell2.08707788
21* MP0002752_abnormal_somatic_nervous2.07543684
22MP0001188_hyperpigmentation2.04723777
23MP0003011_delayed_dark_adaptation10.3247679
24MP0001485_abnormal_pinna_reflex1.81255436
25MP0006292_abnormal_olfactory_placode1.75824704
26MP0003123_paternal_imprinting1.71225571
27MP0001486_abnormal_startle_reflex1.67631811
28MP0004019_abnormal_vitamin_homeostasis1.65930615
29MP0005220_abnormal_exocrine_pancreas1.65193831
30MP0005451_abnormal_body_composition1.56735429
31MP0005647_abnormal_sex_gland1.50395019
32MP0001764_abnormal_homeostasis1.46287397
33MP0003567_abnormal_fetal_cardiomyocyte1.40566986
34MP0005377_hearing/vestibular/ear_phenot1.40476523
35MP0003878_abnormal_ear_physiology1.40476523
36* MP0002882_abnormal_neuron_morphology1.40124826
37MP0000569_abnormal_digit_pigmentation1.40033427
38MP0000537_abnormal_urethra_morphology1.39982987
39MP0001501_abnormal_sleep_pattern1.38151472
40MP0002009_preneoplasia1.38140024
41MP0003329_amyloid_beta_deposits1.37913652
42MP0004742_abnormal_vestibular_system1.31655328
43MP0003119_abnormal_digestive_system1.30421582
44MP0004264_abnormal_extraembryonic_tissu1.27964888
45MP0010234_abnormal_vibrissa_follicle1.22299475
46MP0005379_endocrine/exocrine_gland_phen1.21935652
47MP0003880_abnormal_central_pattern1.21149772
48MP0003136_yellow_coat_color1.20994069
49MP0009046_muscle_twitch1.18783590
50MP0003115_abnormal_respiratory_system1.16606280
51MP0005076_abnormal_cell_differentiation1.15952029
52MP0001502_abnormal_circadian_rhythm1.12640784
53MP0000383_abnormal_hair_follicle1.11120081
54MP0001984_abnormal_olfaction1.09941051
55MP0004043_abnormal_pH_regulation1.08002091
56MP0008057_abnormal_DNA_replication1.03158018
57MP0004142_abnormal_muscle_tone1.03124534
58MP0000566_synostosis1.01317754
59MP0000026_abnormal_inner_ear0.99889460
60MP0000681_abnormal_thyroid_gland0.99857799
61MP0001963_abnormal_hearing_physiology0.99783974
62MP0004381_abnormal_hair_follicle0.98984431
63MP0002653_abnormal_ependyma_morphology0.97811680
64MP0000516_abnormal_urinary_system0.96494619
65MP0005367_renal/urinary_system_phenotyp0.96494619
66MP0003315_abnormal_perineum_morphology0.92169671
67MP0003638_abnormal_response/metabolism_0.91167482
68MP0004270_analgesia0.90834753
69MP0002909_abnormal_adrenal_gland0.90286709
70MP0001440_abnormal_grooming_behavior0.90214058
71MP0001968_abnormal_touch/_nociception0.89969264
72MP0004885_abnormal_endolymph0.89374383
73MP0002272_abnormal_nervous_system0.87647348
74MP0000462_abnormal_digestive_system0.87298061
75MP0002277_abnormal_respiratory_mucosa0.86939734
76MP0000631_abnormal_neuroendocrine_gland0.86306661
77MP0005197_abnormal_uvea_morphology0.85801711
78MP0000604_amyloidosis0.85721285
79MP0005645_abnormal_hypothalamus_physiol0.85584270
80MP0003861_abnormal_nervous_system0.85381913
81MP0002876_abnormal_thyroid_physiology0.84684557
82MP0001944_abnormal_pancreas_morphology0.83826368
83MP0000534_abnormal_ureter_morphology0.81980857
84MP0001727_abnormal_embryo_implantation0.81303237
85MP0002067_abnormal_sensory_capabilities0.81233197
86MP0002733_abnormal_thermal_nociception0.79415463
87MP0006138_congestive_heart_failure0.78964466
88MP0002734_abnormal_mechanical_nocicepti0.77543685
89MP0005409_darkened_coat_color0.75994916
90MP0001286_abnormal_eye_development0.75297840
91MP0003635_abnormal_synaptic_transmissio0.73497917
92MP0005499_abnormal_olfactory_system0.71238205
93MP0005394_taste/olfaction_phenotype0.71238205
94MP0002249_abnormal_larynx_morphology0.70304227
95MP0009745_abnormal_behavioral_response0.69160219
96MP0004197_abnormal_fetal_growth/weight/0.68814585
97MP0002127_abnormal_cardiovascular_syste0.68596085
98MP0006276_abnormal_autonomic_nervous0.67508349
99MP0008789_abnormal_olfactory_epithelium0.66706591
100MP0002064_seizures0.66594927
101MP0002184_abnormal_innervation0.65832723
102MP0008058_abnormal_DNA_repair0.65777859
103MP0005332_abnormal_amino_acid0.65735629
104MP0002572_abnormal_emotion/affect_behav0.65572436
105MP0001970_abnormal_pain_threshold0.64788904
106MP0003718_maternal_effect0.64788889
107MP0002332_abnormal_exercise_endurance0.62514341
108MP0004859_abnormal_synaptic_plasticity0.62175587
109MP0002234_abnormal_pharynx_morphology0.61988881
110MP0000778_abnormal_nervous_system0.60183827
111MP0000427_abnormal_hair_cycle0.58832225
112MP0005623_abnormal_meninges_morphology0.58348674
113MP0010678_abnormal_skin_adnexa0.56993956
114MP0003634_abnormal_glial_cell0.56909081
115MP0000579_abnormal_nail_morphology0.55915620
116MP0002735_abnormal_chemical_nociception0.55331805
117MP0000647_abnormal_sebaceous_gland0.52869013
118MP0000465_gastrointestinal_hemorrhage0.49588058
119MP0008995_early_reproductive_senescence0.49498358
120MP0005171_absent_coat_pigmentation0.49111332
121MP0003938_abnormal_ear_development0.48416501
122MP0003941_abnormal_skin_development0.47968067
123MP0000613_abnormal_salivary_gland0.47749023
124MP0005646_abnormal_pituitary_gland0.47640756
125MP0001346_abnormal_lacrimal_gland0.47468848
126MP0008004_abnormal_stomach_pH0.46600087
127MP0001661_extended_life_span0.46262672
128MP0002063_abnormal_learning/memory/cond0.46223349
129MP0002557_abnormal_social/conspecific_i0.45326025
130MP0000049_abnormal_middle_ear0.41352351
131MP0003045_fibrosis0.41246851
132MP0003787_abnormal_imprinting0.39860555
133MP0001879_abnormal_lymphatic_vessel0.39666270
134MP0002697_abnormal_eye_size0.37949576
135MP0002736_abnormal_nociception_after0.37350896
136MP0004233_abnormal_muscle_weight0.37020186
137MP0000955_abnormal_spinal_cord0.35869332
138MP0002233_abnormal_nose_morphology0.34693833
139MP0000470_abnormal_stomach_morphology0.33993528
140MP0005187_abnormal_penis_morphology0.31162380
141MP0002152_abnormal_brain_morphology0.31032357
142MP0008569_lethality_at_weaning0.30643909
143MP0002066_abnormal_motor_capabilities/c0.30513555
144MP0005257_abnormal_intraocular_pressure0.29592884
145MP0001905_abnormal_dopamine_level0.27829806

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.98744255
2Abnormal rod and cone electroretinograms (HP:0008323)9.14028896
3Dyschromatopsia (HP:0007641)7.73546071
4Chorioretinal atrophy (HP:0000533)7.67758107
5Pigmentary retinal degeneration (HP:0001146)7.55597920
6Attenuation of retinal blood vessels (HP:0007843)7.42298521
7Central scotoma (HP:0000603)7.27881644
8Pendular nystagmus (HP:0012043)7.14420468
9Abnormality of macular pigmentation (HP:0008002)7.02700197
10Scotoma (HP:0000575)6.56295897
11Decreased central vision (HP:0007663)6.31768358
12Abolished electroretinogram (ERG) (HP:0000550)6.16455352
13Genetic anticipation (HP:0003743)5.98254689
14Photophobia (HP:0000613)5.14064455
15Type II diabetes mellitus (HP:0005978)4.89142415
16Keratoconus (HP:0000563)4.83001190
17Increased corneal curvature (HP:0100692)4.83001190
18Persistence of primary teeth (HP:0006335)4.65751505
19Macular degeneration (HP:0000608)4.54105789
20Vitreoretinal degeneration (HP:0000655)4.53534368
21Cone-rod dystrophy (HP:0000548)4.42110239
22Depressed nasal tip (HP:0000437)4.38058999
23Severe visual impairment (HP:0001141)4.28258323
24Impaired smooth pursuit (HP:0007772)4.17532402
25Retinitis pigmentosa (HP:0000510)3.99361249
26Posterior subcapsular cataract (HP:0007787)3.95119636
27Choroideremia (HP:0001139)3.93663387
28Constricted visual fields (HP:0001133)3.80546066
29Abnormality of binocular vision (HP:0011514)3.68551609
30Diplopia (HP:0000651)3.68551609
31Reticulocytopenia (HP:0001896)3.61756466
32Congenital sensorineural hearing impairment (HP:0008527)3.46909042
33Obstructive sleep apnea (HP:0002870)3.46454659
34Decreased electroretinogram (ERG) amplitude (HP:0000654)3.42711201
35Visual hallucinations (HP:0002367)3.41568330
36Abnormality of the fingertips (HP:0001211)3.15330792
37Agammaglobulinemia (HP:0004432)3.05335654
38Hemiparesis (HP:0001269)3.03014215
39Upper limb muscle weakness (HP:0003484)2.99424358
40Lip pit (HP:0100267)2.94113816
41Abnormality of abdominal situs (HP:0011620)2.89713712
42Abdominal situs inversus (HP:0003363)2.89713712
43Abnormality of ocular smooth pursuit (HP:0000617)2.87724155
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82941196
45Duplication of thumb phalanx (HP:0009942)2.82381978
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.79964568
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79187661
48Ectopic kidney (HP:0000086)2.68975332
49Progressive visual loss (HP:0000529)2.68169429
50Subcapsular cataract (HP:0000523)2.66309185
51Sparse lateral eyebrow (HP:0005338)2.66106365
52Abnormality of the axillary hair (HP:0100134)2.65514983
53Abnormality of secondary sexual hair (HP:0009888)2.65514983
54Absent radius (HP:0003974)2.61289223
55High anterior hairline (HP:0009890)2.60178895
56Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56076108
57Febrile seizures (HP:0002373)2.55288054
58Retinal atrophy (HP:0001105)2.51196499
59Dysmetric saccades (HP:0000641)2.49050750
60Proximal tubulopathy (HP:0000114)2.46907601
61Protruding tongue (HP:0010808)2.45403250
62Absent forearm bone (HP:0003953)2.44419805
63Aplasia involving forearm bones (HP:0009822)2.44419805
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.43272769
65Neonatal hypoglycemia (HP:0001998)2.41950385
66Abnormality of saccadic eye movements (HP:0000570)2.37394241
67Chromsome breakage (HP:0040012)2.35875199
68Optic nerve coloboma (HP:0000588)2.34167749
69Periauricular skin pits (HP:0100277)2.30797582
70Preauricular pit (HP:0004467)2.30797582
71Abnormality of the parathyroid morphology (HP:0011766)2.28223195
72Supernumerary spleens (HP:0009799)2.27176668
73Wide nasal bridge (HP:0000431)2.26729957
74Annular pancreas (HP:0001734)2.24459758
75Anal stenosis (HP:0002025)2.24286583
76Gonadotropin excess (HP:0000837)2.22131055
77Gait imbalance (HP:0002141)2.21904909
78Optic disc pallor (HP:0000543)2.21612917
79Truncal obesity (HP:0001956)2.20058866
80Congenital primary aphakia (HP:0007707)2.18348475
81Hyperglycinemia (HP:0002154)2.18070598
82Skin pits (HP:0100276)2.16736406
83Abnormality of the columella (HP:0009929)2.14638472
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.11020658
85Truncal ataxia (HP:0002078)2.09699376
86Germ cell neoplasia (HP:0100728)2.09205659
87Advanced eruption of teeth (HP:0006288)2.07369574
88Abnormal biliary tract physiology (HP:0012439)2.05958046
89Bile duct proliferation (HP:0001408)2.05958046
90Hypoplastic ischia (HP:0003175)2.05379154
91Abnormality of the proximal phalanges of the hand (HP:0009834)2.04715072
92Medial flaring of the eyebrow (HP:0010747)2.04291414
93Hypergonadotropic hypogonadism (HP:0000815)2.03599511
94Abnormality of pyrimidine metabolism (HP:0004353)2.03195408
95* Congenital stationary night blindness (HP:0007642)12.6778802
96Bony spicule pigmentary retinopathy (HP:0007737)10.7627193
97Nephrogenic diabetes insipidus (HP:0009806)1.98832769
98Chronic sinusitis (HP:0011109)1.96929866
99Tachypnea (HP:0002789)1.95411132
100Increased cerebral lipofuscin (HP:0011813)1.94927230
101True hermaphroditism (HP:0010459)1.92527559
102Confusion (HP:0001289)1.91852297
103Abnormality of serine family amino acid metabolism (HP:0010894)1.89302301
104Abnormality of glycine metabolism (HP:0010895)1.89302301
105Clumsiness (HP:0002312)1.87932243
106Progressive external ophthalmoplegia (HP:0000590)1.86402533
107Gaze-evoked nystagmus (HP:0000640)1.86373063
108Ureteral duplication (HP:0000073)1.84861709
109Sleep apnea (HP:0010535)1.83262273
110Hydroureter (HP:0000072)1.81438478
111Severe Myopia (HP:0011003)1.80538223
112Short 1st metacarpal (HP:0010034)1.79861439
113Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79861439
114Choanal stenosis (HP:0000452)1.79592905
115Abnormality of the carotid arteries (HP:0005344)1.78935077
116Abnormality of the ischium (HP:0003174)1.77428755
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.75225983
118Overgrowth (HP:0001548)1.74852556
119Oligodontia (HP:0000677)1.74732881
120Abnormality of DNA repair (HP:0003254)1.74541418
121Azoospermia (HP:0000027)1.74247075
122Septo-optic dysplasia (HP:0100842)1.73968099
123Asplenia (HP:0001746)1.71392048
124Urinary bladder sphincter dysfunction (HP:0002839)1.71240568
125Abnormality of the phalanges of the hallux (HP:0010057)1.71009959
126Pancreatic fibrosis (HP:0100732)1.67801011
127Prostate neoplasm (HP:0100787)1.67789928
128Vaginal atresia (HP:0000148)1.65900714
129Polar cataract (HP:0010696)1.65447944
130Chorioretinal coloboma (HP:0000567)1.64055460
131Genital tract atresia (HP:0001827)1.63407837
132Aplasia/Hypoplasia of the lens (HP:0008063)1.63071868
133Poor coordination (HP:0002370)1.62732946
134Astigmatism (HP:0000483)1.57674481
135Recurrent sinusitis (HP:0011108)1.45937998
136Nephroblastoma (Wilms tumor) (HP:0002667)1.45915937
137Hypoplasia of the fovea (HP:0007750)1.45586190
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.45586190
139Male pseudohermaphroditism (HP:0000037)1.41570833
140Epileptic encephalopathy (HP:0200134)1.36878190
141Optic atrophy (HP:0000648)1.36142335
142Embryonal renal neoplasm (HP:0011794)1.35185747
143Abnormality of the fovea (HP:0000493)1.29123166
144Absent/shortened dynein arms (HP:0200106)1.29007187
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.29007187
146Nephronophthisis (HP:0000090)1.28201492
147Esotropia (HP:0000565)1.28178569
148Lower limb amyotrophy (HP:0007210)1.26859249
149Pancreatic cysts (HP:0001737)1.26767127
150Abnormality of the renal medulla (HP:0100957)1.24356074
151Progressive cerebellar ataxia (HP:0002073)1.21379195
152Duplicated collecting system (HP:0000081)1.20867160
153Osteomalacia (HP:0002749)1.19279713
154Cystic liver disease (HP:0006706)1.17122798
155Congenital hepatic fibrosis (HP:0002612)1.16698523
156Distal lower limb amyotrophy (HP:0008944)1.16016661
157Acute lymphatic leukemia (HP:0006721)1.14551527
158Tubulointerstitial nephritis (HP:0001970)1.14471063
159Corneal dystrophy (HP:0001131)1.13137360
160Chronic hepatic failure (HP:0100626)1.12352896
161Horizontal nystagmus (HP:0000666)1.10686443
162Abnormality of midbrain morphology (HP:0002418)1.10556752
163Molar tooth sign on MRI (HP:0002419)1.10556752
164Sclerocornea (HP:0000647)1.09805464
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.09782629
166Optic nerve hypoplasia (HP:0000609)1.09659935
167Specific learning disability (HP:0001328)1.07986841
168Retinal detachment (HP:0000541)1.06109842
169Postaxial foot polydactyly (HP:0001830)1.05673424
170Chin dimple (HP:0010751)1.04917484
171Interstitial pulmonary disease (HP:0006530)1.03819441
172Abnormality of the renal collecting system (HP:0004742)1.03565279
173Absent speech (HP:0001344)1.03304171
174Double outlet right ventricle (HP:0001719)1.03214622
175Congenital malformation of the right heart (HP:0011723)1.03214622
176Abnormal ciliary motility (HP:0012262)1.02650306
177Dysdiadochokinesis (HP:0002075)1.02620055
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.02518974
179Renal cortical cysts (HP:0000803)1.02278310
180Broad-based gait (HP:0002136)1.01359329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* GRK16.13953431
2PRKD35.28090892
3CASK3.70498010
4TNIK3.15754938
5PBK3.00398698
6INSRR2.47107687
7NTRK32.43525867
8STK162.37494146
9BLK2.30205791
10TRIB32.23894380
11TAOK32.11165558
12IRAK22.07760291
13EIF2AK22.01123044
14TESK210.3912646
15SIK21.98071238
16CAMKK11.87249994
17TAF11.80762932
18PINK11.73171358
19PKN21.69212527
20PKN11.59679418
21NEK61.54248905
22MAP3K131.52112186
23CAMK1G1.49457340
24MAPK151.42178971
25CAMK1D1.34134156
26MAPK71.31461996
27EEF2K1.25712878
28BRD41.21908045
29PRKAA21.18422122
30CDK31.17202094
31TXK1.17159076
32PIK3CA1.16928138
33ADRBK11.16184269
34MARK11.15237358
35MAPK131.12820895
36AKT31.11999970
37MAPKAPK31.11461176
38MKNK21.11051399
39MAP2K71.08969291
40EIF2AK11.06672441
41ADRBK21.06348555
42SGK21.04147473
43MAP3K141.01511470
44FES1.01270819
45PAK30.98331220
46YES10.97653475
47HIPK20.95747368
48MAPK120.95688029
49CSNK1D0.94837056
50WNK40.94281146
51MUSK0.91790680
52MAP3K90.91755232
53NTRK20.90390480
54SGK4940.90219893
55SGK2230.90219893
56WNK10.90117336
57BMPR1B0.88427788
58CDK70.87910646
59PRPF4B0.87141561
60IRAK10.86947830
61PRKCE0.80992319
62SMG10.80960519
63SGK10.79019584
64PNCK0.77858082
65MAP3K40.72652388
66PRKCZ0.71827330
67CAMK10.71166362
68GRK50.69975529
69FRK0.69729849
70GRK70.69477120
71ERBB20.68680451
72MAP3K70.67330611
73PRKD20.65537895
74MTOR0.65039522
75MARK20.62820068
76EPHB20.62556843
77CAMK2A0.60783139
78CAMK2D0.60680594
79LATS10.60250419
80DYRK1A0.59647480
81SIK30.59567885
82MAP4K20.58458827
83PAK60.58324105
84STK110.57765556
85* PRKCB0.57576482
86CAMK40.55099776
87PRKCG0.54805745
88CLK10.54593791
89ZAK0.52659138
90CDC42BPA0.52557304
91SGK30.52264816
92TNK20.52025803
93PRKG10.51560446
94PHKG20.50865418
95PHKG10.50865418
96KSR20.49747375
97FER0.49542108
98PASK0.49430862
99STK390.48997923
100MAP3K60.48439893
101PRKCH0.48315395
102DYRK30.46967213
103JAK10.46276108
104PRKAA10.46209163
105FGR0.45966595
106TTK0.45491637
107NUAK10.44339509
108CDK120.44171127
109GSK3B0.43692623
110TSSK60.43187357
111ACVR1B0.42226146
112* PRKACA0.42150001
113CSNK1A1L0.41843070
114ICK0.41802151
115MAPK100.41770285
116EPHA40.41519428
117PRKDC0.41321041
118DYRK20.41196850
119PIK3CG0.41163648
120SIK10.41016139
121MAPK140.40454844
122MAP2K40.40445848
123STK380.39928241
124TAOK10.39616794
125RPS6KA60.37978355
126TEC0.37335807
127SRPK10.37071120
128RPS6KA30.37048311
129RPS6KL10.36842288
130RPS6KC10.36842288
131AURKA0.35742405
132ATR0.33839036
133MAP3K80.33042707
134RET0.33040244
135CDK90.32770543
136MAP3K10.32390438
137DAPK10.31462498
138CSNK1G30.29480571
139NEK20.26578391
140PRKD10.26483331
141CAMKK20.25555786
142CSNK1A10.24208693
143EIF2AK30.24092897
144CSNK1G20.23849074
145CSNK1G10.20312415
146MAP2K10.19704129
147DAPK20.19549577
148CDK10.18239155
149CHEK20.16889329
150CDK20.16502727
151KSR10.15104092
152CDC70.14782027
153CHUK0.14217819
154CAMK2B0.14165342

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.47384557
2Propanoate metabolism_Homo sapiens_hsa006402.23137106
3* Phototransduction_Homo sapiens_hsa0474414.5454786
4Histidine metabolism_Homo sapiens_hsa003401.95072354
5Arginine and proline metabolism_Homo sapiens_hsa003301.85280057
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.83876812
7Nicotine addiction_Homo sapiens_hsa050331.56482710
8Notch signaling pathway_Homo sapiens_hsa043301.56077273
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.49931767
10Tryptophan metabolism_Homo sapiens_hsa003801.49244425
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.47005088
12Hedgehog signaling pathway_Homo sapiens_hsa043401.45722506
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44759608
14Olfactory transduction_Homo sapiens_hsa047401.43933109
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43709396
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43328387
17Prion diseases_Homo sapiens_hsa050201.41998314
18Fatty acid metabolism_Homo sapiens_hsa012121.31570060
19ABC transporters_Homo sapiens_hsa020101.31036828
20Synaptic vesicle cycle_Homo sapiens_hsa047211.30945108
21Morphine addiction_Homo sapiens_hsa050321.29872057
22GABAergic synapse_Homo sapiens_hsa047271.26729652
23Selenocompound metabolism_Homo sapiens_hsa004501.25644724
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24596798
25Glutamatergic synapse_Homo sapiens_hsa047241.23495957
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23048184
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19203840
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17758270
29mTOR signaling pathway_Homo sapiens_hsa041501.14771097
30Retinol metabolism_Homo sapiens_hsa008301.14217314
31beta-Alanine metabolism_Homo sapiens_hsa004101.10205375
32Serotonergic synapse_Homo sapiens_hsa047261.09843253
33Steroid biosynthesis_Homo sapiens_hsa001001.04337095
34Pyruvate metabolism_Homo sapiens_hsa006201.03466473
35Bile secretion_Homo sapiens_hsa049760.99033050
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98330618
37Cholinergic synapse_Homo sapiens_hsa047250.97712957
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97639369
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.91724345
40Vitamin B6 metabolism_Homo sapiens_hsa007500.89839753
41Circadian entrainment_Homo sapiens_hsa047130.88408545
42AMPK signaling pathway_Homo sapiens_hsa041520.87514516
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85080783
44One carbon pool by folate_Homo sapiens_hsa006700.84099384
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80628784
46Fanconi anemia pathway_Homo sapiens_hsa034600.80462188
47Dopaminergic synapse_Homo sapiens_hsa047280.78659946
48PPAR signaling pathway_Homo sapiens_hsa033200.77926292
49Circadian rhythm_Homo sapiens_hsa047100.77654224
50Fatty acid elongation_Homo sapiens_hsa000620.74483356
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74385077
52Other glycan degradation_Homo sapiens_hsa005110.73399961
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73085208
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72624956
55B cell receptor signaling pathway_Homo sapiens_hsa046620.72117028
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70559482
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69712278
58Thyroid cancer_Homo sapiens_hsa052160.69497743
59Taste transduction_Homo sapiens_hsa047420.69048953
60Insulin secretion_Homo sapiens_hsa049110.67325283
61Base excision repair_Homo sapiens_hsa034100.66832570
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66093456
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65205411
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63842664
65Calcium signaling pathway_Homo sapiens_hsa040200.62818514
66Oxytocin signaling pathway_Homo sapiens_hsa049210.61992210
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61976155
68cAMP signaling pathway_Homo sapiens_hsa040240.60706066
69Cocaine addiction_Homo sapiens_hsa050300.59833134
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58742327
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58573268
72Melanogenesis_Homo sapiens_hsa049160.57237891
73Sphingolipid metabolism_Homo sapiens_hsa006000.56911063
74Fatty acid degradation_Homo sapiens_hsa000710.56325101
75VEGF signaling pathway_Homo sapiens_hsa043700.56270024
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55905614
77Axon guidance_Homo sapiens_hsa043600.55300377
78Salivary secretion_Homo sapiens_hsa049700.51678102
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51384614
80Butanoate metabolism_Homo sapiens_hsa006500.51076208
81Renin secretion_Homo sapiens_hsa049240.49694232
82Inositol phosphate metabolism_Homo sapiens_hsa005620.49611398
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48628528
84Amphetamine addiction_Homo sapiens_hsa050310.48620027
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.48228139
86Biosynthesis of amino acids_Homo sapiens_hsa012300.48154117
87Lysine degradation_Homo sapiens_hsa003100.47023718
88Arginine biosynthesis_Homo sapiens_hsa002200.46948551
89Glucagon signaling pathway_Homo sapiens_hsa049220.46301060
90Dilated cardiomyopathy_Homo sapiens_hsa054140.45957143
91Estrogen signaling pathway_Homo sapiens_hsa049150.45756713
92Gastric acid secretion_Homo sapiens_hsa049710.45380747
93Prostate cancer_Homo sapiens_hsa052150.44843376
94Ether lipid metabolism_Homo sapiens_hsa005650.44101630
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43900302
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43897891
97Ovarian steroidogenesis_Homo sapiens_hsa049130.43855038
98Phenylalanine metabolism_Homo sapiens_hsa003600.43828681
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43086730
100Ras signaling pathway_Homo sapiens_hsa040140.42787414
101Nitrogen metabolism_Homo sapiens_hsa009100.42105629
102Non-homologous end-joining_Homo sapiens_hsa034500.41658420
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41651116
104Insulin signaling pathway_Homo sapiens_hsa049100.41385832
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41127890
106Caffeine metabolism_Homo sapiens_hsa002320.40448888
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38821777
108Type II diabetes mellitus_Homo sapiens_hsa049300.38534560
109Linoleic acid metabolism_Homo sapiens_hsa005910.37104167
110Purine metabolism_Homo sapiens_hsa002300.36233193
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.35111153
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.34190546
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32712460
114MAPK signaling pathway_Homo sapiens_hsa040100.32165876
115Wnt signaling pathway_Homo sapiens_hsa043100.31164419
116Vitamin digestion and absorption_Homo sapiens_hsa049770.30087248
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30007220
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29640399
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.27530891
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.27483641
121Cardiac muscle contraction_Homo sapiens_hsa042600.25680229
122Autoimmune thyroid disease_Homo sapiens_hsa053200.25305587
123Melanoma_Homo sapiens_hsa052180.24702147
124Choline metabolism in cancer_Homo sapiens_hsa052310.24178255
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22968992
126Pancreatic secretion_Homo sapiens_hsa049720.22182870
127* Chemokine signaling pathway_Homo sapiens_hsa040620.21683949
128Protein digestion and absorption_Homo sapiens_hsa049740.21417787
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20284077
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.20250110
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20124625
132Arachidonic acid metabolism_Homo sapiens_hsa005900.20097256
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19938950
134ECM-receptor interaction_Homo sapiens_hsa045120.19846894
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19708646
136ErbB signaling pathway_Homo sapiens_hsa040120.19618406
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19568406
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19313108
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18493027
140Alcoholism_Homo sapiens_hsa050340.17992281
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17824574
142Mineral absorption_Homo sapiens_hsa049780.17524659
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16866311
144GnRH signaling pathway_Homo sapiens_hsa049120.16073036
145Glycerolipid metabolism_Homo sapiens_hsa005610.16021238
146Basal cell carcinoma_Homo sapiens_hsa052170.15940545
147Long-term depression_Homo sapiens_hsa047300.15224689
148Asthma_Homo sapiens_hsa053100.14419908
149Fatty acid biosynthesis_Homo sapiens_hsa000610.13696274
150Rheumatoid arthritis_Homo sapiens_hsa053230.13658130
151Dorso-ventral axis formation_Homo sapiens_hsa043200.13321623
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12536640
153Collecting duct acid secretion_Homo sapiens_hsa049660.12427363

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