GRK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.25194292
2cilium or flagellum-dependent cell motility (GO:0001539)4.69783777
3superoxide anion generation (GO:0042554)4.31465826
4pyrimidine nucleobase catabolic process (GO:0006208)3.74072509
5axonemal dynein complex assembly (GO:0070286)3.63616138
6response to pheromone (GO:0019236)3.61331428
7gamma-aminobutyric acid transport (GO:0015812)3.59547132
8protein polyglutamylation (GO:0018095)3.56445083
9righting reflex (GO:0060013)3.53320646
10presynaptic membrane assembly (GO:0097105)3.36729403
11motile cilium assembly (GO:0044458)3.36214366
12regulation of cilium movement (GO:0003352)3.35415248
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31867890
14acrosome reaction (GO:0007340)3.31450926
15cilium movement (GO:0003341)3.31117604
16synaptic transmission, cholinergic (GO:0007271)3.30379703
17female gonad development (GO:0008585)3.26706988
18startle response (GO:0001964)3.21599545
19centriole assembly (GO:0098534)3.19147460
20microtubule depolymerization (GO:0007019)3.17996609
21nonmotile primary cilium assembly (GO:0035058)3.16251338
22neuronal action potential (GO:0019228)3.16066640
23epithelial cilium movement (GO:0003351)3.15569212
24somite development (GO:0061053)3.14672624
25nucleobase catabolic process (GO:0046113)3.14139790
26regulation of non-canonical Wnt signaling pathway (GO:2000050)3.11849303
27reflex (GO:0060004)3.10055058
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.04954162
29NADH dehydrogenase complex assembly (GO:0010257)3.04954162
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04954162
31DNA integration (GO:0015074)3.04827334
32neural tube formation (GO:0001841)3.04141281
33left/right axis specification (GO:0070986)3.03797257
34negative regulation of transcription regulatory region DNA binding (GO:2000678)3.03391664
35platelet dense granule organization (GO:0060155)3.01819673
36L-fucose catabolic process (GO:0042355)3.01688001
37fucose catabolic process (GO:0019317)3.01688001
38L-fucose metabolic process (GO:0042354)3.01688001
39regulation of timing of cell differentiation (GO:0048505)3.01626911
40negative regulation of telomere maintenance (GO:0032205)3.01389154
41presynaptic membrane organization (GO:0097090)3.00727596
42detection of light stimulus involved in visual perception (GO:0050908)3.00635917
43detection of light stimulus involved in sensory perception (GO:0050962)3.00635917
44mesenchymal cell differentiation involved in kidney development (GO:0072161)2.98334632
45mesenchymal cell differentiation involved in renal system development (GO:2001012)2.98334632
46energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97417339
47ATP synthesis coupled proton transport (GO:0015986)2.97417339
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94485727
49spinal cord motor neuron differentiation (GO:0021522)2.94391619
50multicellular organism reproduction (GO:0032504)2.94095530
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93939299
52regulation of microtubule-based movement (GO:0060632)2.93134579
53water-soluble vitamin biosynthetic process (GO:0042364)2.92739204
54protein complex biogenesis (GO:0070271)2.89521534
55regulation of rhodopsin mediated signaling pathway (GO:0022400)2.84043892
56transmission of nerve impulse (GO:0019226)2.84037426
57axoneme assembly (GO:0035082)2.81748053
58DNA methylation involved in gamete generation (GO:0043046)2.81174499
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80431496
60retinal ganglion cell axon guidance (GO:0031290)2.80300438
61behavioral response to ethanol (GO:0048149)2.79746984
62cell proliferation in forebrain (GO:0021846)2.79144831
63protein localization to cilium (GO:0061512)2.78747771
64neuronal action potential propagation (GO:0019227)2.78080766
65regulation of platelet aggregation (GO:0090330)2.77642293
66negative regulation of DNA-dependent DNA replication (GO:2000104)2.77230600
67membrane depolarization during action potential (GO:0086010)2.76964776
68rhodopsin mediated signaling pathway (GO:0016056)2.76905617
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76417109
70inner ear receptor stereocilium organization (GO:0060122)2.76198641
71negative regulation of mast cell activation (GO:0033004)2.75191200
72negative regulation of homotypic cell-cell adhesion (GO:0034111)2.73885712
73limb bud formation (GO:0060174)2.73018911
74indolalkylamine metabolic process (GO:0006586)2.72443979
75retinal cone cell development (GO:0046549)2.70043426
76cerebral cortex radially oriented cell migration (GO:0021799)2.69873333
77androgen biosynthetic process (GO:0006702)2.69612029
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69568551
79neuromuscular synaptic transmission (GO:0007274)2.69332103
80developmental pigmentation (GO:0048066)2.69233551
81postsynaptic membrane organization (GO:0001941)2.68400155
82kynurenine metabolic process (GO:0070189)2.66959502
83primary amino compound metabolic process (GO:1901160)2.66740795
84auditory receptor cell stereocilium organization (GO:0060088)2.66515214
85preassembly of GPI anchor in ER membrane (GO:0016254)2.65499640
86DNA deamination (GO:0045006)2.65398388
87regulation of action potential (GO:0098900)2.65057253
88RNA destabilization (GO:0050779)2.64823412
89keratinocyte development (GO:0003334)2.63809255
90positive regulation of cellular amide metabolic process (GO:0034250)2.62578797
91protein-cofactor linkage (GO:0018065)2.62142130
92auditory behavior (GO:0031223)2.62109861
93regulation of pigment cell differentiation (GO:0050932)2.61782706
94intraciliary transport (GO:0042073)2.61705832
95opioid receptor signaling pathway (GO:0038003)2.61421618
96kidney morphogenesis (GO:0060993)2.61386554
97synaptic transmission, glutamatergic (GO:0035249)2.60725449
98protein localization to synapse (GO:0035418)2.60316325
99positive regulation of meiosis (GO:0045836)2.60271271
100mitochondrial respiratory chain complex assembly (GO:0033108)2.59675033
101polyketide metabolic process (GO:0030638)2.59397778
102doxorubicin metabolic process (GO:0044598)2.59397778
103daunorubicin metabolic process (GO:0044597)2.59397778
104sulfation (GO:0051923)2.59106858
105cellular response to ATP (GO:0071318)2.58533757
106polyol transport (GO:0015791)2.58385386
107cell differentiation in spinal cord (GO:0021515)2.58263576
108negative regulation of osteoblast proliferation (GO:0033689)2.57932116
109superoxide metabolic process (GO:0006801)2.57767552
110cellular ketone body metabolic process (GO:0046950)2.57313565
111cranial nerve structural organization (GO:0021604)2.57108230
112protein neddylation (GO:0045116)2.56307177
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.54842506
114extracellular regulation of signal transduction (GO:1900115)2.54752112
115extracellular negative regulation of signal transduction (GO:1900116)2.54752112
116regulation of development, heterochronic (GO:0040034)2.52942238
117mechanosensory behavior (GO:0007638)2.52448646
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51578135
119positive regulation of oligodendrocyte differentiation (GO:0048714)2.51412487
120regulation of activation of Janus kinase activity (GO:0010533)2.50413122
121positive regulation of interleukin-1 beta secretion (GO:0050718)2.49445414
122cilium morphogenesis (GO:0060271)2.48943975
123serotonin metabolic process (GO:0042428)2.47855602
124tryptophan catabolic process (GO:0006569)2.47494780
125indole-containing compound catabolic process (GO:0042436)2.47494780
126indolalkylamine catabolic process (GO:0046218)2.47494780
127action potential (GO:0001508)2.47036503
128positive regulation of action potential (GO:0045760)2.46760268
129cyclic nucleotide catabolic process (GO:0009214)2.45465029
130substrate-independent telencephalic tangential migration (GO:0021826)2.44069604
131substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44069604
132photoreceptor cell maintenance (GO:0045494)2.44005499
133negative regulation of myoblast differentiation (GO:0045662)2.43945054
134cilium assembly (GO:0042384)2.43709600
135histone H3-K4 trimethylation (GO:0080182)2.43633584
136histone H3-K36 demethylation (GO:0070544)2.43628360
137dentate gyrus development (GO:0021542)2.43564505
138photoreceptor cell development (GO:0042461)2.43239383
139positive regulation of protein homodimerization activity (GO:0090073)2.42913497
140retina layer formation (GO:0010842)2.42224679
141axon ensheathment in central nervous system (GO:0032291)2.41983205
142central nervous system myelination (GO:0022010)2.41983205
143nephron tubule morphogenesis (GO:0072078)2.41133403
144nephron epithelium morphogenesis (GO:0072088)2.41133403
145positive regulation of meiotic cell cycle (GO:0051446)2.41028503
146negative regulation of appetite (GO:0032099)2.40366836
147negative regulation of response to food (GO:0032096)2.40366836
148regulation of germinal center formation (GO:0002634)2.40246372
149ubiquinone biosynthetic process (GO:0006744)2.40136898
150response to X-ray (GO:0010165)2.39905125
151DNA strand renaturation (GO:0000733)2.39218924
152sulfate transmembrane transport (GO:1902358)2.39133848
153regulation of DNA endoreduplication (GO:0032875)2.38939440
154neuron cell-cell adhesion (GO:0007158)2.38781908
155synapsis (GO:0007129)2.37387671
156negative regulation of keratinocyte proliferation (GO:0010839)2.36809849
157regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36803415
158detection of other organism (GO:0098543)2.36667497
159adenosine metabolic process (GO:0046085)2.35124536
160positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.34943117
161glutamate receptor signaling pathway (GO:0007215)2.34841930
162sperm motility (GO:0030317)2.34244915
163cAMP catabolic process (GO:0006198)2.34143399
164cranial nerve morphogenesis (GO:0021602)2.33797668
165cilium organization (GO:0044782)2.33772183
166regulation of NIK/NF-kappaB signaling (GO:1901222)2.32907901
167mesenchymal cell differentiation (GO:0048762)2.32632665
168positive regulation of uterine smooth muscle contraction (GO:0070474)2.32347114
169negative regulation of granulocyte differentiation (GO:0030853)2.32174242
170piRNA metabolic process (GO:0034587)2.31566215
171response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.31446954
172response to host immune response (GO:0052572)2.31446954
173lymphoid progenitor cell differentiation (GO:0002320)2.29627420
174facial nerve structural organization (GO:0021612)2.28755158
175detection of bacterium (GO:0016045)2.28092118
176cell morphogenesis involved in neuron differentiation (GO:0048667)2.27710473
177positive regulation of interleukin-1 secretion (GO:0050716)2.26966166
178cornea development in camera-type eye (GO:0061303)2.26595049
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26466528
180ventricular system development (GO:0021591)2.25292962
181sympathetic nervous system development (GO:0048485)2.25036567
182long-chain fatty acid biosynthetic process (GO:0042759)2.24975172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.92086601
2EZH2_22144423_ChIP-Seq_EOC_Human3.48306318
3ZNF274_21170338_ChIP-Seq_K562_Hela3.24201171
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.92421752
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.83572527
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.61996960
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.47587206
8SUZ12_27294783_Chip-Seq_NPCs_Mouse2.43324037
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37309842
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35976949
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35614869
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.31103023
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19915668
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16627179
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13446537
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.07399255
17TAF15_26573619_Chip-Seq_HEK293_Human2.07355276
18EZH2_27294783_Chip-Seq_NPCs_Mouse2.06040119
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02524755
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.01854431
21EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.01128278
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.99031102
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95637419
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91016155
25P53_22387025_ChIP-Seq_ESCs_Mouse1.89441477
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88904077
27E2F1_18555785_Chip-Seq_ESCs_Mouse1.87736172
28SUZ12_18555785_Chip-Seq_ESCs_Mouse1.86157681
29IGF1R_20145208_ChIP-Seq_DFB_Human1.82868078
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.81991000
31P300_19829295_ChIP-Seq_ESCs_Human1.81369401
32EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77224491
33CMYC_18555785_Chip-Seq_ESCs_Mouse1.76856873
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76008761
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74954412
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.74849929
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.74694370
38NMYC_18555785_Chip-Seq_ESCs_Mouse1.73469136
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73377944
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72926858
41P300_18555785_Chip-Seq_ESCs_Mouse1.72518763
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66867148
43OCT4_18555785_Chip-Seq_ESCs_Mouse1.65162891
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65100705
45FUS_26573619_Chip-Seq_HEK293_Human1.64846717
46RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64659415
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62936589
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.62408952
49VDR_22108803_ChIP-Seq_LS180_Human1.61469096
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.60526093
51RNF2_27304074_Chip-Seq_NSC_Mouse1.59145717
52SMAD4_21799915_ChIP-Seq_A2780_Human1.58759380
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58405293
54PU1_27457419_Chip-Seq_LIVER_Mouse1.57167680
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56529578
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55753418
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55030219
58ZFX_18555785_Chip-Seq_ESCs_Mouse1.54332432
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53413652
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.53044250
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52709116
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.52110099
63CTCF_18555785_Chip-Seq_ESCs_Mouse1.46480083
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46322710
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.46176787
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.45431317
67SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43651171
68* TAL1_26923725_Chip-Seq_HPCs_Mouse1.42200943
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41795898
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41795898
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41371826
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41182806
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.41070388
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.41044690
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.38812787
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38805727
77BCAT_22108803_ChIP-Seq_LS180_Human1.38527675
78ER_23166858_ChIP-Seq_MCF-7_Human1.37472840
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37078545
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35801365
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35473093
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35189413
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34569680
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34569680
85KDM2B_26808549_Chip-Seq_REH_Human1.32380863
86TP53_22573176_ChIP-Seq_HFKS_Human1.32013888
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.31715265
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.31522704
89EWS_26573619_Chip-Seq_HEK293_Human1.31471123
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31367168
91STAT3_23295773_ChIP-Seq_U87_Human1.31165226
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31127374
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30587375
94CBP_20019798_ChIP-Seq_JUKART_Human1.30587375
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30246386
96IRF1_19129219_ChIP-ChIP_H3396_Human1.29750855
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28405252
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25955989
99TCF4_23295773_ChIP-Seq_U87_Human1.25946984
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.25412857
101TP53_18474530_ChIP-ChIP_U2OS_Human1.24851340
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22422787
103AR_21572438_ChIP-Seq_LNCaP_Human1.21393849
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18184756
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17970238
106RUNX2_22187159_ChIP-Seq_PCA_Human1.16956410
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16728916
108DROSHA_22980978_ChIP-Seq_HELA_Human1.16225935
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15480251
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.15444373
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15260297
112SOX2_19829295_ChIP-Seq_ESCs_Human1.14459205
113NANOG_19829295_ChIP-Seq_ESCs_Human1.14459205
114* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13239184
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11950510
116AR_25329375_ChIP-Seq_VCAP_Human1.10077476
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09522602
118REST_21632747_ChIP-Seq_MESCs_Mouse1.09474201
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.09296852
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09245874
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07127446
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06992225
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06444273
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05597080
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05529892
126TCF4_22108803_ChIP-Seq_LS180_Human1.03950547
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03906380
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03501846
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.03501846
130NCOR_22424771_ChIP-Seq_293T_Human1.03117220
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.02891078
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.02887155
133TAF2_19829295_ChIP-Seq_ESCs_Human1.02598938
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.02374012
135KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01456454
136* MYC_18940864_ChIP-ChIP_HL60_Human0.99988530
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97078395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.86728446
2MP0002102_abnormal_ear_morphology3.69677483
3MP0003136_yellow_coat_color3.40898933
4MP0000566_synostosis3.35720700
5MP0006292_abnormal_olfactory_placode2.95175240
6MP0005409_darkened_coat_color2.75732754
7MP0003880_abnormal_central_pattern2.62861150
8MP0004381_abnormal_hair_follicle2.45965575
9MP0005645_abnormal_hypothalamus_physiol2.44176239
10MP0000015_abnormal_ear_pigmentation2.27693196
11MP0005171_absent_coat_pigmentation2.25454116
12MP0005410_abnormal_fertilization2.22207808
13MP0000569_abnormal_digit_pigmentation2.19170462
14MP0002277_abnormal_respiratory_mucosa2.19082971
15MP0004885_abnormal_endolymph2.04102714
16MP0001986_abnormal_taste_sensitivity2.03751706
17MP0004742_abnormal_vestibular_system2.03313184
18MP0002653_abnormal_ependyma_morphology1.97735601
19MP0001486_abnormal_startle_reflex1.94758804
20MP0005174_abnormal_tail_pigmentation1.93141675
21MP0003787_abnormal_imprinting1.90785256
22MP0000383_abnormal_hair_follicle1.87441203
23MP0005646_abnormal_pituitary_gland1.85513337
24MP0003011_delayed_dark_adaptation1.85499248
25MP0002735_abnormal_chemical_nociception1.77180189
26MP0005379_endocrine/exocrine_gland_phen1.74405792
27MP0005423_abnormal_somatic_nervous1.68457941
28MP0003941_abnormal_skin_development1.66740092
29MP0002837_dystrophic_cardiac_calcinosis1.65782384
30MP0002733_abnormal_thermal_nociception1.58811173
31MP0001970_abnormal_pain_threshold1.57089573
32MP0001485_abnormal_pinna_reflex1.56346113
33MP0003646_muscle_fatigue1.53320252
34MP0002876_abnormal_thyroid_physiology1.52440551
35MP0005670_abnormal_white_adipose1.50199413
36MP0008058_abnormal_DNA_repair1.48053548
37MP0009046_muscle_twitch1.48015438
38MP0000026_abnormal_inner_ear1.47093802
39MP0004133_heterotaxia1.46538218
40MP0001968_abnormal_touch/_nociception1.46288634
41MP0008995_early_reproductive_senescence1.45098093
42MP0002234_abnormal_pharynx_morphology1.44886711
43MP0002160_abnormal_reproductive_system1.44039651
44MP0006276_abnormal_autonomic_nervous1.43420586
45MP0008872_abnormal_physiological_respon1.42466103
46MP0004043_abnormal_pH_regulation1.41807608
47MP0002822_catalepsy1.37314711
48MP0002163_abnormal_gland_morphology1.37231342
49MP0005451_abnormal_body_composition1.37217045
50MP0008260_abnormal_autophagy1.37206498
51MP0005084_abnormal_gallbladder_morpholo1.36920129
52MP0005551_abnormal_eye_electrophysiolog1.36437411
53MP0008877_abnormal_DNA_methylation1.36320257
54MP0002736_abnormal_nociception_after1.35160400
55MP0010386_abnormal_urinary_bladder1.34569311
56MP0008789_abnormal_olfactory_epithelium1.33047964
57MP0009745_abnormal_behavioral_response1.32956614
58MP0003122_maternal_imprinting1.27205262
59MP0008875_abnormal_xenobiotic_pharmacok1.26421530
60MP0000579_abnormal_nail_morphology1.25611587
61MP0004145_abnormal_muscle_electrophysio1.25460780
62MP0003195_calcinosis1.25052308
63MP0004147_increased_porphyrin_level1.24351450
64MP0001963_abnormal_hearing_physiology1.23906038
65MP0001502_abnormal_circadian_rhythm1.21340061
66MP0002638_abnormal_pupillary_reflex1.19418525
67MP0001501_abnormal_sleep_pattern1.18459326
68MP0002067_abnormal_sensory_capabilities1.18393901
69MP0004859_abnormal_synaptic_plasticity1.17404928
70MP0005389_reproductive_system_phenotype1.17333348
71MP0003121_genomic_imprinting1.17219655
72MP0004142_abnormal_muscle_tone1.15992207
73MP0005386_behavior/neurological_phenoty1.14567370
74MP0004924_abnormal_behavior1.14567370
75MP0009697_abnormal_copulation1.12200839
76MP0003698_abnormal_male_reproductive1.11843377
77MP0001440_abnormal_grooming_behavior1.11503444
78MP0001346_abnormal_lacrimal_gland1.11461132
79MP0002572_abnormal_emotion/affect_behav1.11405597
80MP0005499_abnormal_olfactory_system1.10999054
81MP0005394_taste/olfaction_phenotype1.10999054
82MP0003283_abnormal_digestive_organ1.10254286
83MP0002249_abnormal_larynx_morphology1.09845731
84MP0001984_abnormal_olfaction1.09835981
85MP0000955_abnormal_spinal_cord1.09185589
86MP0000427_abnormal_hair_cycle1.07905156
87MP0005195_abnormal_posterior_eye1.05340676
88MP0002928_abnormal_bile_duct1.03830646
89MP0002095_abnormal_skin_pigmentation1.03639341
90MP0000778_abnormal_nervous_system1.03348195
91MP0002557_abnormal_social/conspecific_i1.02586311
92MP0003938_abnormal_ear_development1.00423400
93MP0005257_abnormal_intraocular_pressure0.99868329
94MP0002882_abnormal_neuron_morphology0.99666618
95MP0002909_abnormal_adrenal_gland0.99180462
96MP0005377_hearing/vestibular/ear_phenot0.98718259
97MP0003878_abnormal_ear_physiology0.98718259
98MP0002272_abnormal_nervous_system0.97762139
99MP0005253_abnormal_eye_physiology0.97457655
100MP0002938_white_spotting0.96306069
101MP0002132_abnormal_respiratory_system0.95501667
102MP0004270_analgesia0.94159908
103MP0002751_abnormal_autonomic_nervous0.93965421
104MP0000631_abnormal_neuroendocrine_gland0.93929383
105MP0005075_abnormal_melanosome_morpholog0.93694932
106MP0000372_irregular_coat_pigmentation0.93067303
107MP0001919_abnormal_reproductive_system0.92601371
108MP0006072_abnormal_retinal_apoptosis0.92247385
109MP0003879_abnormal_hair_cell0.92230832
110MP0003724_increased_susceptibility_to0.88774762
111MP0000049_abnormal_middle_ear0.88687035
112MP0000230_abnormal_systemic_arterial0.87629392
113MP0002184_abnormal_innervation0.85472925
114MP0002752_abnormal_somatic_nervous0.85430008
115MP0003045_fibrosis0.84032678
116MP0002177_abnormal_outer_ear0.81218480
117MP0001529_abnormal_vocalization0.80740278
118MP0003635_abnormal_synaptic_transmissio0.80433933
119MP0010678_abnormal_skin_adnexa0.77680161
120MP0005647_abnormal_sex_gland0.77419926
121MP0001905_abnormal_dopamine_level0.76054012
122MP0002063_abnormal_learning/memory/cond0.75690236
123MP0001929_abnormal_gametogenesis0.75200982
124MP0002148_abnormal_hypersensitivity_rea0.74753086
125MP0002210_abnormal_sex_determination0.73659167
126MP0009250_abnormal_appendicular_skeleto0.73320465
127MP0002064_seizures0.73143212
128MP0005387_immune_system_phenotype0.71801611
129MP0001790_abnormal_immune_system0.71801611
130MP0000462_abnormal_digestive_system0.71472493
131MP0002734_abnormal_mechanical_nocicepti0.71339802
132MP0004484_altered_response_of0.70508016
133MP0002009_preneoplasia0.67730073
134MP0001186_pigmentation_phenotype0.65105481
135MP0002233_abnormal_nose_morphology0.64928075
136MP0004134_abnormal_chest_morphology0.63703516
137MP0009764_decreased_sensitivity_to0.63575936
138MP0009379_abnormal_foot_pigmentation0.63027214
139MP0000538_abnormal_urinary_bladder0.62189685
140MP0000762_abnormal_tongue_morphology0.61940488
141MP0000647_abnormal_sebaceous_gland0.60418825

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.06227170
2Chromsome breakage (HP:0040012)5.26794373
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.92109304
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.92085096
5Absent/shortened dynein arms (HP:0200106)4.92085096
6Abnormal ciliary motility (HP:0012262)4.13481936
7Febrile seizures (HP:0002373)3.87064838
8Abnormal respiratory motile cilium physiology (HP:0012261)3.86907213
9Prostate neoplasm (HP:0100787)3.84384820
10Duplicated collecting system (HP:0000081)3.78584628
11Abnormal respiratory motile cilium morphology (HP:0005938)3.65125644
12Abnormal respiratory epithelium morphology (HP:0012253)3.65125644
13Abnormality of the renal collecting system (HP:0004742)3.52440535
14Upper limb muscle weakness (HP:0003484)3.51908080
15Type II lissencephaly (HP:0007260)3.39515964
16Hyperventilation (HP:0002883)3.19359505
17Polydipsia (HP:0001959)2.99279226
18Abnormal drinking behavior (HP:0030082)2.99279226
19Septo-optic dysplasia (HP:0100842)2.86181239
20Progressive cerebellar ataxia (HP:0002073)2.83804165
21Tubulointerstitial nephritis (HP:0001970)2.79735212
22Aplasia cutis congenita (HP:0001057)2.73557444
23Nephronophthisis (HP:0000090)2.72804716
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.68607946
25Polyuria (HP:0000103)2.68418712
26Sclerocornea (HP:0000647)2.65605951
27Congenital stationary night blindness (HP:0007642)2.63608458
28Decreased central vision (HP:0007663)2.62747471
29Acute necrotizing encephalopathy (HP:0006965)2.61334503
30Cystic liver disease (HP:0006706)2.59575540
31Focal motor seizures (HP:0011153)2.59460296
32Lissencephaly (HP:0001339)2.56369933
33Abnormality of DNA repair (HP:0003254)2.55796597
34Abnormality of the preputium (HP:0100587)2.55592944
35Congenital sensorineural hearing impairment (HP:0008527)2.55573773
36Abnormality of the renal medulla (HP:0100957)2.53375319
37Abnormal rod and cone electroretinograms (HP:0008323)2.44687943
38Gait imbalance (HP:0002141)2.44370126
39Median cleft lip (HP:0000161)2.42362091
40Clubbing of toes (HP:0100760)2.40377744
41Limb dystonia (HP:0002451)2.39996607
42Abnormality of the labia minora (HP:0012880)2.39423760
43White forelock (HP:0002211)2.38497867
44Acute encephalopathy (HP:0006846)2.35000431
45Chronic hepatic failure (HP:0100626)2.34639506
46Rhinitis (HP:0012384)2.32923467
47Patchy hypopigmentation of hair (HP:0011365)2.32634579
48Duplication of thumb phalanx (HP:0009942)2.32235700
49Mitochondrial inheritance (HP:0001427)2.31752357
50Meckel diverticulum (HP:0002245)2.31031335
51Abnormality of incisor morphology (HP:0011063)2.30515736
52Progressive macrocephaly (HP:0004481)2.27144235
53Fair hair (HP:0002286)2.26736229
54Mesomelia (HP:0003027)2.25371191
55Tubular atrophy (HP:0000092)2.25112380
56Abnormality of the ileum (HP:0001549)2.22711052
57Focal seizures (HP:0007359)2.21882342
58Abnormal mitochondria in muscle tissue (HP:0008316)2.21627672
59Cerebellar dysplasia (HP:0007033)2.21528318
60Optic nerve hypoplasia (HP:0000609)2.20583858
61Congenital primary aphakia (HP:0007707)2.20309021
62Ectopic kidney (HP:0000086)2.19986079
63Renal cortical cysts (HP:0000803)2.19766581
64Broad-based gait (HP:0002136)2.19071740
65Pachygyria (HP:0001302)2.19056106
66Abnormal urine output (HP:0012590)2.18840229
67Pendular nystagmus (HP:0012043)2.18790362
68True hermaphroditism (HP:0010459)2.16396051
69Male pseudohermaphroditism (HP:0000037)2.15951293
70Rib fusion (HP:0000902)2.15447529
71Abolished electroretinogram (ERG) (HP:0000550)2.15407313
72Concave nail (HP:0001598)2.15109184
73Hemiparesis (HP:0001269)2.14873602
74Congenital hepatic fibrosis (HP:0002612)2.14533478
75Medial flaring of the eyebrow (HP:0010747)2.12837500
76Anencephaly (HP:0002323)2.12756257
77Agitation (HP:0000713)2.12020626
78Congenital, generalized hypertrichosis (HP:0004540)2.10529023
79Osteomalacia (HP:0002749)2.10357208
80Myokymia (HP:0002411)2.09631134
81Optic neuritis (HP:0100653)2.08659101
82Retrobulbar optic neuritis (HP:0100654)2.08659101
83Inability to walk (HP:0002540)2.08508400
84Postaxial foot polydactyly (HP:0001830)2.07606163
85Lipid accumulation in hepatocytes (HP:0006561)2.07288365
86Increased CSF lactate (HP:0002490)2.06314412
87Nephrogenic diabetes insipidus (HP:0009806)2.05728832
88Abnormality of chromosome stability (HP:0003220)2.05008631
89Nephroblastoma (Wilms tumor) (HP:0002667)2.01844396
90Abnormality of the nasal septum (HP:0000419)2.01374712
91Decreased circulating renin level (HP:0003351)2.00518136
92Epileptic encephalopathy (HP:0200134)1.99449983
93Hypothermia (HP:0002045)1.98934558
94Increased hepatocellular lipid droplets (HP:0006565)1.98132619
95Methylmalonic acidemia (HP:0002912)1.97976692
96Patellar aplasia (HP:0006443)1.97783274
97Absent speech (HP:0001344)1.97720258
98Bony spicule pigmentary retinopathy (HP:0007737)1.97596592
99Abnormality of the renal cortex (HP:0011035)1.97377480
100Optic disc pallor (HP:0000543)1.96753496
101Lip pit (HP:0100267)1.96256031
102Retinal dysplasia (HP:0007973)1.95596387
103Aplasia/Hypoplasia of the patella (HP:0006498)1.95589558
1043-Methylglutaconic aciduria (HP:0003535)1.95149933
105Metabolic alkalosis (HP:0200114)1.93709345
106Preaxial hand polydactyly (HP:0001177)1.93680390
107Distal lower limb amyotrophy (HP:0008944)1.92876337
108Protruding tongue (HP:0010808)1.92007100
109Generalized hypopigmentation of hair (HP:0011358)1.91679899
110Renal Fanconi syndrome (HP:0001994)1.91300860
111Absent septum pellucidum (HP:0001331)1.91216556
112Genital tract atresia (HP:0001827)1.91174727
113Abnormality of the prostate (HP:0008775)1.91171114
114Attenuation of retinal blood vessels (HP:0007843)1.90722488
115Anophthalmia (HP:0000528)1.88829089
116Conical tooth (HP:0000698)1.88580449
117Embryonal renal neoplasm (HP:0011794)1.87833440
118Vaginal atresia (HP:0000148)1.87734397
119Alveolar cell carcinoma (HP:0006519)1.87368588
120Pancreatic fibrosis (HP:0100732)1.87241917
121Abnormality of renal excretion (HP:0011036)1.86347556
122Increased corneal curvature (HP:0100692)1.83982594
123Keratoconus (HP:0000563)1.83982594
124Gaze-evoked nystagmus (HP:0000640)1.83275698
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.83045241
126Genetic anticipation (HP:0003743)1.82251279
127Large for gestational age (HP:0001520)1.81999103
128Microvesicular hepatic steatosis (HP:0001414)1.81555694
129Postaxial hand polydactyly (HP:0001162)1.80431933
130Dialeptic seizures (HP:0011146)1.79792609
131Abnormality of the carotid arteries (HP:0005344)1.79176211
132Submucous cleft hard palate (HP:0000176)1.79096954
133Polyphagia (HP:0002591)1.79045282
134Distal lower limb muscle weakness (HP:0009053)1.79029205
135Abnormality of midbrain morphology (HP:0002418)1.76783786
136Molar tooth sign on MRI (HP:0002419)1.76783786
137Hypokalemic alkalosis (HP:0001949)1.76296871
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.76143221
139Hypomagnesemia (HP:0002917)1.74460617
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73755335
141Hyperalaninemia (HP:0003348)1.73755335
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72974839
143Recurrent sinusitis (HP:0011108)1.72662855
144Abnormality of the septum pellucidum (HP:0007375)1.69775192
145Abnormal hair whorl (HP:0010721)1.69361240
146Abnormality of the axillary hair (HP:0100134)1.68249318
147Abnormality of secondary sexual hair (HP:0009888)1.68249318
148Astigmatism (HP:0000483)1.67609057
149Oligodactyly (hands) (HP:0001180)1.67089839
150Atelectasis (HP:0100750)1.66042326
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.65998585
152Hypoplasia of the fovea (HP:0007750)1.65998585
153Renal agenesis (HP:0000104)1.64682389
154Anomalous pulmonary venous return (HP:0010772)1.64007207
155Abnormality of molar (HP:0011077)1.63450066
156Abnormality of molar morphology (HP:0011070)1.63450066
157Dyschromatopsia (HP:0007641)1.61481567
158Facial cleft (HP:0002006)1.60838600
159Overfolded helix (HP:0000396)1.60046506
160Lower limb amyotrophy (HP:0007210)1.59989246
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.57705821
162Nasolacrimal duct obstruction (HP:0000579)1.56633896
163Bronchiectasis (HP:0002110)1.56189644
164Hypergonadotropic hypogonadism (HP:0000815)1.55933736
165Exotropia (HP:0000577)1.55702975
166Pancreatic cysts (HP:0001737)1.55614628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.68383844
2TNIK3.28269751
3INSRR2.94126266
4EIF2AK22.85035433
5WNK42.75765603
6PINK12.51193105
7MAP4K22.46674590
8TXK2.37675472
9STK162.33261480
10GRK12.19840383
11IRAK32.11901647
12ZAK2.11752494
13PNCK2.10414777
14MAP3K141.94000212
15ADRBK21.88178923
16GRK71.86918663
17MKNK21.79517943
18DYRK21.78465598
19MAP2K71.76646764
20YES11.65633911
21MUSK1.65616731
22NTRK31.64347215
23IRAK41.63167697
24BLK1.54905336
25BMPR1B1.48341326
26CAMKK21.47771257
27NEK61.44436783
28BCKDK1.44157625
29CDK31.40724698
30NUAK11.36254338
31MAPK131.34736319
32SIK31.34639036
33TRIM281.34538292
34BMPR21.33898424
35PKN11.33558674
36TNK21.28744983
37PAK31.27797355
38DAPK21.23780312
39RIPK41.22604772
40ADRBK11.20291014
41MAP3K131.16347501
42BRD41.15374596
43IRAK11.11866336
44ACVR1B1.07258000
45PRPF4B1.07113980
46EPHA41.06684621
47PHKG21.02587513
48PHKG11.02587513
49TIE11.00874501
50MKNK11.00724352
51SGK21.00014982
52MAP3K90.95515547
53TEC0.95143982
54CSNK1G20.90956535
55SIK20.89458914
56EPHA30.89380745
57PRKCE0.87702307
58CLK10.87326193
59MAPK150.86500888
60PIK3CG0.86297578
61SRPK10.84758405
62AKT30.83191096
63FRK0.79374389
64NTRK20.78611175
65IRAK20.75450183
66SGK10.72913497
67JAK10.72897350
68PLK20.71739226
69MINK10.71703617
70PIK3CA0.71317326
71TGFBR10.70851449
72CAMK1G0.68859205
73TAOK30.66703894
74IKBKB0.66335776
75STK110.65809766
76WNK10.65774940
77OBSCN0.63783406
78PRKCZ0.63490197
79DYRK30.62906083
80FGR0.61592585
81SGK2230.61094530
82SGK4940.61094530
83CAMK2A0.61049541
84PRKCQ0.60435907
85CAMKK10.60229734
86MAPK70.59951531
87FES0.59767220
88STK390.58612342
89IKBKE0.57023257
90NME10.55983607
91PRKAA20.55621478
92CSNK1G30.55353026
93LYN0.55344659
94BCR0.54546248
95STK38L0.53802609
96NLK0.53611355
97PRKCI0.53435643
98OXSR10.52883038
99WNK30.52795349
100CAMK1D0.52721077
101CSNK1G10.52168691
102PRKG10.52153964
103VRK10.51841362
104CDK80.51829734
105MAP3K40.51128680
106CDK90.51013241
107PTK2B0.48760530
108TAF10.47792967
109CAMK40.47732715
110FGFR20.47409862
111CDK50.44385786
112GRK50.44266883
113CSNK1A10.44178514
114LATS10.43374075
115PLK40.43056388
116MAPKAPK30.42198293
117MARK10.42017194
118CAMK10.41512222
119MAP3K60.41381628
120TRPM70.40801325
121PRKCA0.40577859
122ATR0.40503437
123CAMK2B0.38776851
124PBK0.38658447
125PRKCG0.38650979
126NEK20.38553219
127PAK60.38249262
128CHUK0.37830422
129PRKACA0.37786673
130CSNK1D0.36801080
131EPHB20.36467005
132HCK0.36357970
133MAP2K40.35858959
134CAMK2D0.35803986
135KIT0.35760601
136DYRK1A0.35244301
137RPS6KA50.34883485
138LIMK10.34787959
139LCK0.34461825
140MAP2K20.34400807
141WEE10.33877865
142MAPKAPK50.33407082
143PRKAA10.33308512
144TLK10.31782191

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17169430
2Oxidative phosphorylation_Homo sapiens_hsa001902.83047774
3Fanconi anemia pathway_Homo sapiens_hsa034602.78949746
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.61871536
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.50298592
6Parkinsons disease_Homo sapiens_hsa050122.31249316
7Phototransduction_Homo sapiens_hsa047442.19242963
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15667941
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14633934
10Nitrogen metabolism_Homo sapiens_hsa009102.14003912
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.05651493
12Taste transduction_Homo sapiens_hsa047422.04570377
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03374162
14Cardiac muscle contraction_Homo sapiens_hsa042601.94924671
15Butanoate metabolism_Homo sapiens_hsa006501.82346186
16Autoimmune thyroid disease_Homo sapiens_hsa053201.77581929
17Sphingolipid metabolism_Homo sapiens_hsa006001.71440846
18Graft-versus-host disease_Homo sapiens_hsa053321.66203829
19Protein export_Homo sapiens_hsa030601.61897697
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60527555
21Alzheimers disease_Homo sapiens_hsa050101.58236741
22Huntingtons disease_Homo sapiens_hsa050161.55356116
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54702961
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.51534517
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51510625
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51435339
27Serotonergic synapse_Homo sapiens_hsa047261.48130367
28Calcium signaling pathway_Homo sapiens_hsa040201.44132595
29Allograft rejection_Homo sapiens_hsa053301.43254888
30* Morphine addiction_Homo sapiens_hsa050321.42434757
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41365587
32Glutamatergic synapse_Homo sapiens_hsa047241.40076317
33Non-homologous end-joining_Homo sapiens_hsa034501.39496060
34Tryptophan metabolism_Homo sapiens_hsa003801.38913417
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.37897247
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37221433
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36768812
38Ether lipid metabolism_Homo sapiens_hsa005651.35838590
39Hematopoietic cell lineage_Homo sapiens_hsa046401.30842165
40Ribosome_Homo sapiens_hsa030101.30331875
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29075665
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27388958
43Selenocompound metabolism_Homo sapiens_hsa004501.24056084
44Arachidonic acid metabolism_Homo sapiens_hsa005901.20996972
45Homologous recombination_Homo sapiens_hsa034401.20442156
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19093367
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18937384
48Caffeine metabolism_Homo sapiens_hsa002321.17714502
49Dopaminergic synapse_Homo sapiens_hsa047281.13060814
50RNA polymerase_Homo sapiens_hsa030201.12512527
51Rheumatoid arthritis_Homo sapiens_hsa053231.12157772
52Propanoate metabolism_Homo sapiens_hsa006401.11254842
53Axon guidance_Homo sapiens_hsa043601.07199340
54ABC transporters_Homo sapiens_hsa020101.05839878
55Ovarian steroidogenesis_Homo sapiens_hsa049131.04952821
56Olfactory transduction_Homo sapiens_hsa047401.04150153
57Vitamin digestion and absorption_Homo sapiens_hsa049771.03660666
58Measles_Homo sapiens_hsa051621.02935633
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00764032
60Circadian entrainment_Homo sapiens_hsa047130.99965760
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99960198
62Asthma_Homo sapiens_hsa053100.99821164
63Linoleic acid metabolism_Homo sapiens_hsa005910.99239490
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.97260579
65Primary immunodeficiency_Homo sapiens_hsa053400.94292304
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92562516
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92410310
68Chemical carcinogenesis_Homo sapiens_hsa052040.92256250
69Amphetamine addiction_Homo sapiens_hsa050310.90570882
70African trypanosomiasis_Homo sapiens_hsa051430.89797929
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89138908
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.88138262
73Inositol phosphate metabolism_Homo sapiens_hsa005620.87599574
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87169765
75Renin secretion_Homo sapiens_hsa049240.86857347
76Salivary secretion_Homo sapiens_hsa049700.86240745
77Regulation of autophagy_Homo sapiens_hsa041400.86052798
78Peroxisome_Homo sapiens_hsa041460.85985717
79Basal transcription factors_Homo sapiens_hsa030220.84091443
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83945970
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83610853
82cAMP signaling pathway_Homo sapiens_hsa040240.83424630
83Synaptic vesicle cycle_Homo sapiens_hsa047210.81671986
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81075063
85Malaria_Homo sapiens_hsa051440.80665276
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77922344
87Histidine metabolism_Homo sapiens_hsa003400.77607745
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76858433
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75776333
90Insulin secretion_Homo sapiens_hsa049110.75066467
91Fat digestion and absorption_Homo sapiens_hsa049750.72899274
92GABAergic synapse_Homo sapiens_hsa047270.71459275
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70081476
94Glycerolipid metabolism_Homo sapiens_hsa005610.69929029
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68904128
96Cocaine addiction_Homo sapiens_hsa050300.68560539
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68352038
98Other glycan degradation_Homo sapiens_hsa005110.68301027
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.67632758
100Retinol metabolism_Homo sapiens_hsa008300.67311055
101TNF signaling pathway_Homo sapiens_hsa046680.65830100
102Sulfur relay system_Homo sapiens_hsa041220.65693066
103Collecting duct acid secretion_Homo sapiens_hsa049660.64787629
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64043276
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63620479
106beta-Alanine metabolism_Homo sapiens_hsa004100.63291918
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.61648941
108Basal cell carcinoma_Homo sapiens_hsa052170.61303824
109Long-term depression_Homo sapiens_hsa047300.61039663
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.60430113
111Ras signaling pathway_Homo sapiens_hsa040140.60093993
112Steroid biosynthesis_Homo sapiens_hsa001000.58933394
113Gastric acid secretion_Homo sapiens_hsa049710.57959590
114Purine metabolism_Homo sapiens_hsa002300.57425958
115Herpes simplex infection_Homo sapiens_hsa051680.57050315
116RNA degradation_Homo sapiens_hsa030180.56711153
117Cholinergic synapse_Homo sapiens_hsa047250.56458676
118Osteoclast differentiation_Homo sapiens_hsa043800.56394230
119Fatty acid biosynthesis_Homo sapiens_hsa000610.54839721
120Circadian rhythm_Homo sapiens_hsa047100.54556134
121Metabolic pathways_Homo sapiens_hsa011000.54410627
122ECM-receptor interaction_Homo sapiens_hsa045120.54120884
123Dorso-ventral axis formation_Homo sapiens_hsa043200.53947843
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53752550
125Phagosome_Homo sapiens_hsa041450.53667762
126Influenza A_Homo sapiens_hsa051640.53546604
127Wnt signaling pathway_Homo sapiens_hsa043100.53056404
128Type I diabetes mellitus_Homo sapiens_hsa049400.52983753
129One carbon pool by folate_Homo sapiens_hsa006700.52138142
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51778786
131Sulfur metabolism_Homo sapiens_hsa009200.50889244
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48721211
133Hedgehog signaling pathway_Homo sapiens_hsa043400.47636787
134MAPK signaling pathway_Homo sapiens_hsa040100.46500427
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45669945
136Choline metabolism in cancer_Homo sapiens_hsa052310.45230698
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44550511
138Mineral absorption_Homo sapiens_hsa049780.44186695
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43718684
140Melanoma_Homo sapiens_hsa052180.42688580
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42337054
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42304810
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42144321
144Oxytocin signaling pathway_Homo sapiens_hsa049210.42098176
145Type II diabetes mellitus_Homo sapiens_hsa049300.41679154
146Pancreatic secretion_Homo sapiens_hsa049720.39714089
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.36617701
148Fatty acid degradation_Homo sapiens_hsa000710.32682162
149Alcoholism_Homo sapiens_hsa050340.31835294

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