GRK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.96597110
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68601209
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.51174554
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.51174554
5negative regulation of cell killing (GO:0031342)5.40376343
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.40376343
7antigen processing and presentation of endogenous antigen (GO:0019883)5.36737446
8positive thymic T cell selection (GO:0045059)5.26759169
9regulation of gamma-delta T cell differentiation (GO:0045586)5.25936595
10positive regulation by symbiont of host defense response (GO:0052509)5.01677628
11modulation by symbiont of host defense response (GO:0052031)5.01677628
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01677628
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01677628
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.01677628
15modulation by symbiont of host immune response (GO:0052553)5.01677628
16negative T cell selection (GO:0043383)4.76825019
17negative thymic T cell selection (GO:0045060)4.73036985
18regulation of gamma-delta T cell activation (GO:0046643)4.66803121
19detection of other organism (GO:0098543)4.55599480
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54625205
21detection of bacterium (GO:0016045)4.51316478
22neutrophil activation involved in immune response (GO:0002283)4.50518367
23thymic T cell selection (GO:0045061)4.48420123
24B cell receptor signaling pathway (GO:0050853)4.46581143
25positive T cell selection (GO:0043368)4.45860760
26response to peptidoglycan (GO:0032494)4.44370010
27regulation of B cell receptor signaling pathway (GO:0050855)4.22972314
28response to interleukin-15 (GO:0070672)4.16950913
29T cell selection (GO:0045058)4.16948369
30cellular extravasation (GO:0045123)3.96876097
31macrophage activation involved in immune response (GO:0002281)3.96609770
32respiratory burst (GO:0045730)3.81312585
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.75829786
34leukocyte aggregation (GO:0070486)3.74455382
35regulation of interferon-beta biosynthetic process (GO:0045357)3.69236083
36DNA unwinding involved in DNA replication (GO:0006268)3.67684735
37negative regulation of interleukin-12 production (GO:0032695)3.67589041
38detection of external biotic stimulus (GO:0098581)3.62801894
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.61705620
40regulation of B cell differentiation (GO:0045577)3.59610444
41response to muramyl dipeptide (GO:0032495)3.55991309
42T cell migration (GO:0072678)3.48550584
43positive regulation of histone deacetylation (GO:0031065)3.48510906
44antigen receptor-mediated signaling pathway (GO:0050851)3.47219867
45negative regulation of leukocyte mediated immunity (GO:0002704)3.45930854
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45497526
47response to host immune response (GO:0052572)3.45497526
48immunoglobulin mediated immune response (GO:0016064)3.45205626
49cellular response to interleukin-15 (GO:0071350)3.44475303
50regulation of mast cell degranulation (GO:0043304)3.41137584
51negative regulation of phagocytosis (GO:0050765)3.41030411
52negative regulation of histone methylation (GO:0031061)3.40220007
53neutrophil activation (GO:0042119)3.38948473
54interferon-gamma production (GO:0032609)3.37286079
55negative regulation of T cell mediated immunity (GO:0002710)3.35732035
56positive regulation of B cell differentiation (GO:0045579)3.34245424
57T cell receptor signaling pathway (GO:0050852)3.33677147
58T cell costimulation (GO:0031295)3.27924903
59response to host (GO:0075136)3.27202168
60response to host defenses (GO:0052200)3.27202168
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27202168
62tolerance induction (GO:0002507)3.25779843
63viral transcription (GO:0019083)3.24269869
64leukocyte migration involved in inflammatory response (GO:0002523)3.23947767
65regulation of interleukin-12 biosynthetic process (GO:0045075)3.23818449
66myeloid cell activation involved in immune response (GO:0002275)3.22499442
67pre-miRNA processing (GO:0031054)3.21958561
68regulation of leukocyte degranulation (GO:0043300)3.20689929
69lymphocyte costimulation (GO:0031294)3.20355579
70detection of biotic stimulus (GO:0009595)3.19986313
71regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18987770
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17700169
73granulocyte activation (GO:0036230)3.16119794
74protein localization to kinetochore (GO:0034501)3.07300747
75translational termination (GO:0006415)3.06826518
76regulation of mast cell activation involved in immune response (GO:0033006)3.04585647
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.04125444
78detection of molecule of bacterial origin (GO:0032490)3.02986846
79natural killer cell differentiation (GO:0001779)3.02363167
80germinal center formation (GO:0002467)3.01516118
81type I interferon signaling pathway (GO:0060337)3.00169358
82cellular response to type I interferon (GO:0071357)3.00169358
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00050830
84response to type I interferon (GO:0034340)2.99510516
85positive regulation of granulocyte differentiation (GO:0030854)2.97554723
86nuclear pore complex assembly (GO:0051292)2.96139750
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96020620
88leukocyte degranulation (GO:0043299)2.95038064
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94297247
90T cell homeostasis (GO:0043029)2.92397530
91regulation of tolerance induction (GO:0002643)2.91985299
92ribosomal small subunit assembly (GO:0000028)2.91431491
93defense response to protozoan (GO:0042832)2.90890575
94regulation of natural killer cell mediated immunity (GO:0002715)2.88032473
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88032473
96immune response-activating cell surface receptor signaling pathway (GO:0002429)2.86858021
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85242679
98negative regulation of innate immune response (GO:0045824)2.84691591
99positive regulation of protein deacetylation (GO:0090312)2.83909983
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83756994
101negative regulation of RNA splicing (GO:0033119)2.83149569
102NIK/NF-kappaB signaling (GO:0038061)2.81955080
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81494432
104regulation of alpha-beta T cell proliferation (GO:0046640)2.81087123
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80923840
106lymphocyte homeostasis (GO:0002260)2.80790190
107regulation of translational fidelity (GO:0006450)2.80214709
108activated T cell proliferation (GO:0050798)2.79451341
109positive regulation of mast cell activation (GO:0033005)2.77723309
110translational elongation (GO:0006414)2.76487791
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75916607
112B cell mediated immunity (GO:0019724)2.75840454
113neutrophil mediated immunity (GO:0002446)2.75125624
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74570420
115alternative mRNA splicing, via spliceosome (GO:0000380)2.74232222
116dosage compensation (GO:0007549)2.74095840
117regulation of T cell tolerance induction (GO:0002664)2.72944323
118nuclear pore organization (GO:0006999)2.72370474
119DNA duplex unwinding (GO:0032508)2.72209759
120regulation of histone H3-K9 methylation (GO:0051570)2.71992191
121modulation by virus of host process (GO:0019054)2.71939460
122megakaryocyte development (GO:0035855)2.71742550
123regulation of T-helper 2 cell differentiation (GO:0045628)2.71235931
124macrophage activation (GO:0042116)2.71222294
125leukocyte cell-cell adhesion (GO:0007159)2.71066298
126production of molecular mediator involved in inflammatory response (GO:0002532)2.71038208
127regulation of regulated secretory pathway (GO:1903305)2.70631352
128negative regulation of interleukin-6 production (GO:0032715)2.70626732
129negative regulation of erythrocyte differentiation (GO:0045647)2.68625530
130B cell homeostasis (GO:0001782)2.68465956
131DNA geometric change (GO:0032392)2.68327562
132mitotic chromosome condensation (GO:0007076)2.66663640
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66563355
134cellular response to interleukin-4 (GO:0071353)2.66190856
135antigen processing and presentation via MHC class Ib (GO:0002475)2.66011768
136protein localization to chromosome, centromeric region (GO:0071459)2.65500516
137regulation of isotype switching to IgG isotypes (GO:0048302)2.64927557
138endothelial tube morphogenesis (GO:0061154)2.64837675
139morphogenesis of an endothelium (GO:0003159)2.64837675
140positive regulation of lamellipodium assembly (GO:0010592)2.64837324
141cellular response to zinc ion (GO:0071294)2.64577175
142positive regulation of Rap GTPase activity (GO:0032854)2.60740726
143regulation of translational termination (GO:0006449)2.59387966
144positive regulation of interleukin-2 production (GO:0032743)2.58611198
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57287957
146positive regulation of isotype switching (GO:0045830)2.57234360
147mitotic nuclear envelope disassembly (GO:0007077)2.54850439
1483-UTR-mediated mRNA stabilization (GO:0070935)2.54845525
149sister chromatid segregation (GO:0000819)2.54306660
150regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.53051885
151ncRNA 3-end processing (GO:0043628)2.52387225
152regulation of response to interferon-gamma (GO:0060330)2.52281764
153V(D)J recombination (GO:0033151)2.50014770
154regulation of T cell receptor signaling pathway (GO:0050856)2.48430786
155response to laminar fluid shear stress (GO:0034616)2.48203301
156heterochromatin organization (GO:0070828)2.45973885
157translational initiation (GO:0006413)2.44392812
158cellular protein complex disassembly (GO:0043624)2.43309998
159mature B cell differentiation (GO:0002335)2.43148418
160membrane disassembly (GO:0030397)2.40744139
161nuclear envelope disassembly (GO:0051081)2.40744139
162viral life cycle (GO:0019058)2.39482716
163B cell proliferation (GO:0042100)2.39428276
164mRNA stabilization (GO:0048255)2.38838967
165RNA stabilization (GO:0043489)2.38838967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87060946
2MYC_22102868_ChIP-Seq_BL_Human4.45785555
3* FOXM1_23109430_ChIP-Seq_U2OS_Human3.69918174
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.48723885
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34425197
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.25806042
7VDR_21846776_ChIP-Seq_THP-1_Human3.12395172
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84659229
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68625017
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.50561227
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.49615576
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41459633
13* MAF_26560356_Chip-Seq_TH1_Human2.40197108
14* UTX_26944678_Chip-Seq_JUKART_Human2.32608705
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.31154431
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29402875
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22818103
18* MYB_26560356_Chip-Seq_TH2_Human2.18226765
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.15584515
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.14259459
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11512005
22* KDM2B_26808549_Chip-Seq_DND41_Human2.08472897
23* MYB_26560356_Chip-Seq_TH1_Human2.04432343
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00683929
25CIITA_25753668_ChIP-Seq_RAJI_Human1.98133700
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93838440
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90365468
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89927378
29RUNX_20019798_ChIP-Seq_JUKART_Human1.89883624
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84523186
31VDR_24763502_ChIP-Seq_THP-1_Human1.81305789
32* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75478347
33SCL_19346495_ChIP-Seq_HPC-7_Human1.73734150
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.73273434
35MAF_26560356_Chip-Seq_TH2_Human1.72555500
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.71560511
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71460396
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70855041
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70808027
40* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70559027
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70493987
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69243707
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67414909
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66653945
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65017548
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63096142
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59254385
48SPI1_23547873_ChIP-Seq_NB4_Human1.58012472
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45951109
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45946765
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42270878
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.40312533
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40132067
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38102109
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35991889
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35110844
57* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33514441
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.33028412
59* XRN2_22483619_ChIP-Seq_HELA_Human1.32519343
60* P68_20966046_ChIP-Seq_HELA_Human1.30858969
61* BCOR_27268052_Chip-Seq_Bcells_Human1.29536993
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29368684
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.29365764
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.29224089
65SPI1_23127762_ChIP-Seq_K562_Human1.29171902
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29149083
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27554237
68* BCL6_27268052_Chip-Seq_Bcells_Human1.27020594
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24650131
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.24225417
71LXR_22292898_ChIP-Seq_THP-1_Human1.22334104
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21752951
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21139403
74* NCOR1_26117541_ChIP-Seq_K562_Human1.19480588
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.19172728
76GATA1_19941826_ChIP-Seq_K562_Human1.19031246
77KDM5A_27292631_Chip-Seq_BREAST_Human1.16832454
78* GATA3_27048872_Chip-Seq_THYMUS_Human1.15708213
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15605328
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13984650
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13555552
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12951008
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12509650
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11798347
85FOXP3_21729870_ChIP-Seq_TREG_Human1.10735016
86* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08979278
87* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08557225
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.07405804
89KDM2B_26808549_Chip-Seq_K562_Human1.05781480
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05229547
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04869524
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04617338
93* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04563998
94VDR_23849224_ChIP-Seq_CD4+_Human1.03112155
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03019496
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01520343
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99787451
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99263166
99SMC4_20622854_ChIP-Seq_HELA_Human0.98304726
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97464147
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97442858
102MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97110073
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96441292
104CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95681731
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95028684
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.94633933
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93954406
108GATA1_22025678_ChIP-Seq_K562_Human0.93953248
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93926647
110TFEB_21752829_ChIP-Seq_HELA_Human0.93673947
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93556157
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92435194
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90317592
114CTCF_21964334_Chip-Seq_Bcells_Human0.89873501
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89609306
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89449246
117RACK7_27058665_Chip-Seq_MCF-7_Human0.88853904
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.87929995
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87584852
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86126227
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85359437
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84557880
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84450587
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84049220
125* GATA1_19941827_ChIP-Seq_MEL_Mouse0.83467824
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83445331
127ATF3_27146783_Chip-Seq_COLON_Human0.82971784
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81982519
129HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81755543
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81273311
131PU_27001747_Chip-Seq_BMDM_Mouse0.79584210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.55512560
2MP0000685_abnormal_immune_system3.31921902
3MP0003724_increased_susceptibility_to3.27874635
4MP0001800_abnormal_humoral_immune3.21760663
5MP0003303_peritoneal_inflammation3.09070977
6MP0001835_abnormal_antigen_presentation2.98507257
7MP0001790_abnormal_immune_system2.96904250
8MP0005387_immune_system_phenotype2.96904250
9MP0002396_abnormal_hematopoietic_system2.89002878
10MP0002398_abnormal_bone_marrow2.77053194
11MP0010352_gastrointestinal_tract_polyps2.67399271
12* MP0002452_abnormal_antigen_presenting2.48783405
13MP0003300_gastrointestinal_ulcer2.47743790
14MP0005671_abnormal_response_to2.47521549
15* MP0002420_abnormal_adaptive_immunity2.45778888
16* MP0001819_abnormal_immune_cell2.40124954
17MP0002723_abnormal_immune_serum2.32638996
18MP0000703_abnormal_thymus_morphology2.30592995
19MP0004808_abnormal_hematopoietic_stem2.29268533
20MP0005000_abnormal_immune_tolerance2.28104946
21MP0000716_abnormal_immune_system2.27977370
22MP0000689_abnormal_spleen_morphology2.27855003
23MP0002722_abnormal_immune_system2.27160129
24MP0005451_abnormal_body_composition2.21419681
25MP0008260_abnormal_autophagy2.14369036
26MP0002166_altered_tumor_susceptibility2.11987078
27MP0009333_abnormal_splenocyte_physiolog2.11201514
28MP0003436_decreased_susceptibility_to2.07106205
29MP0001873_stomach_inflammation2.05599318
30MP0003111_abnormal_nucleus_morphology2.03034539
31MP0009278_abnormal_bone_marrow2.00999676
32MP0003693_abnormal_embryo_hatching1.99900721
33MP0002429_abnormal_blood_cell1.99450553
34MP0003077_abnormal_cell_cycle1.97422780
35MP0002405_respiratory_system_inflammati1.95146009
36MP0003191_abnormal_cellular_cholesterol1.93915816
37MP0005076_abnormal_cell_differentiation1.92249844
38MP0010094_abnormal_chromosome_stability1.91492649
39MP0003172_abnormal_lysosome_physiology1.88777062
40MP0004957_abnormal_blastocyst_morpholog1.82185543
41MP0005025_abnormal_response_to1.79285803
42MP0010155_abnormal_intestine_physiology1.76205224
43MP0004947_skin_inflammation1.75213202
44MP0004381_abnormal_hair_follicle1.71801386
45MP0003705_abnormal_hypodermis_morpholog1.68186100
46MP0003866_abnormal_defecation1.64614835
47MP0000490_abnormal_crypts_of1.63702618
48MP0005397_hematopoietic_system_phenotyp1.62197999
49MP0001545_abnormal_hematopoietic_system1.62197999
50MP0005058_abnormal_lysosome_morphology1.62160729
51MP0005464_abnormal_platelet_physiology1.61192813
52MP0002006_tumorigenesis1.58961981
53MP0010307_abnormal_tumor_latency1.53729891
54MP0008057_abnormal_DNA_replication1.52803002
55MP0002132_abnormal_respiratory_system1.51233800
56MP0002419_abnormal_innate_immunity1.45147332
57MP0009785_altered_susceptibility_to1.42100260
58MP0002019_abnormal_tumor_incidence1.40954219
59MP0001730_embryonic_growth_arrest1.40311706
60MP0000350_abnormal_cell_proliferation1.38469323
61MP0000465_gastrointestinal_hemorrhage1.34734212
62MP0003828_pulmonary_edema1.34733641
63MP0001845_abnormal_inflammatory_respons1.33593288
64MP0003566_abnormal_cell_adhesion1.29339728
65MP0010234_abnormal_vibrissa_follicle1.28642929
66MP0004510_myositis1.28312268
67MP0008961_abnormal_basal_metabolism1.24861655
68MP0000858_altered_metastatic_potential1.23282681
69MP0001853_heart_inflammation1.21318731
70MP0005023_abnormal_wound_healing1.15372033
71MP0003183_abnormal_peptide_metabolism1.13304692
72MP0002933_joint_inflammation1.11110420
73MP0002998_abnormal_bone_remodeling1.08653984
74MP0002148_abnormal_hypersensitivity_rea1.05593702
75MP0002086_abnormal_extraembryonic_tissu1.02428673
76MP0003656_abnormal_erythrocyte_physiolo1.00748093
77MP0002009_preneoplasia0.99563358
78MP0006054_spinal_hemorrhage0.99316371
79MP0003448_altered_tumor_morphology0.96333861
80MP0002080_prenatal_lethality0.95118083
81MP0000313_abnormal_cell_death0.94687087
82MP0003984_embryonic_growth_retardation0.93957798
83MP0004185_abnormal_adipocyte_glucose0.93610254
84MP0008007_abnormal_cellular_replicative0.93155550
85MP0001672_abnormal_embryogenesis/_devel0.93122429
86MP0005380_embryogenesis_phenotype0.93122429
87MP0002088_abnormal_embryonic_growth/wei0.92737656
88MP0001697_abnormal_embryo_size0.91838880
89MP0009840_abnormal_foam_cell0.91238887
90MP0003091_abnormal_cell_migration0.90180634
91MP0004197_abnormal_fetal_growth/weight/0.89797221
92MP0009764_decreased_sensitivity_to0.89286875
93MP0005310_abnormal_salivary_gland0.88769907
94MP0000015_abnormal_ear_pigmentation0.87715530
95MP0000477_abnormal_intestine_morphology0.84045552
96MP0005083_abnormal_biliary_tract0.83049290
97MP0003075_altered_response_to0.83024515
98MP0005174_abnormal_tail_pigmentation0.81813495
99MP0001663_abnormal_digestive_system0.81524837
100MP0004883_abnormal_blood_vessel0.80659710
101MP0005075_abnormal_melanosome_morpholog0.80380067
102MP0000733_abnormal_muscle_development0.79530513
103MP0002277_abnormal_respiratory_mucosa0.79396276
104MP0000569_abnormal_digit_pigmentation0.79355731
105MP0008770_decreased_survivor_rate0.78660966
106MP0005166_decreased_susceptibility_to0.78467814
107MP0002877_abnormal_melanocyte_morpholog0.76312621
108MP0005621_abnormal_cell_physiology0.75841060
109MP0008058_abnormal_DNA_repair0.75682997
110MP0001986_abnormal_taste_sensitivity0.74902313
111MP0002084_abnormal_developmental_patter0.74782457
112MP0001533_abnormal_skeleton_physiology0.71549471
113MP0005390_skeleton_phenotype0.70427970
114MP0002085_abnormal_embryonic_tissue0.70193504
115MP0006082_CNS_inflammation0.69282906
116MP0003123_paternal_imprinting0.68758108
117MP0009763_increased_sensitivity_to0.68523568
118MP0003221_abnormal_cardiomyocyte_apopto0.66562752
119MP0003787_abnormal_imprinting0.65710396
120MP0008874_decreased_physiological_sensi0.63443327
121MP0003806_abnormal_nucleotide_metabolis0.61641485
122MP0000343_altered_response_to0.60577236
123MP0001849_ear_inflammation0.60164496
124MP0002925_abnormal_cardiovascular_devel0.60098551
125MP0005384_cellular_phenotype0.59804221
126MP0003453_abnormal_keratinocyte_physiol0.59387424
127MP0003795_abnormal_bone_structure0.59361293
128MP0008469_abnormal_protein_level0.59006263
129MP0001915_intracranial_hemorrhage0.58969469
130MP0004130_abnormal_muscle_cell0.58942122
131MP0001851_eye_inflammation0.58231107
132MP0000604_amyloidosis0.57546630
133MP0003279_aneurysm0.57318599
134MP0001348_abnormal_lacrimal_gland0.56860709
135MP0009931_abnormal_skin_appearance0.56280653
136MP0005666_abnormal_adipose_tissue0.55227363
137MP0000609_abnormal_liver_physiology0.53275994

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.85076318
2Recurrent bronchitis (HP:0002837)4.18014779
3IgM deficiency (HP:0002850)4.08630743
4T lymphocytopenia (HP:0005403)4.02761707
5Agammaglobulinemia (HP:0004432)4.02166006
6Recurrent viral infections (HP:0004429)4.00057428
7Recurrent gram-negative bacterial infections (HP:0005420)3.99311573
8Verrucae (HP:0200043)3.97830368
9Papilloma (HP:0012740)3.97830368
10Orchitis (HP:0100796)3.92650053
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.91382654
12Gastrointestinal infarctions (HP:0005244)3.91088916
13Cellulitis (HP:0100658)3.78945434
14Abnormality of T cell number (HP:0011839)3.77116585
15Chronic otitis media (HP:0000389)3.68824648
16Panhypogammaglobulinemia (HP:0003139)3.68265033
17Optic neuritis (HP:0100653)3.57711572
18Retrobulbar optic neuritis (HP:0100654)3.57711572
19Recurrent fungal infections (HP:0002841)3.43956319
20Gastrointestinal inflammation (HP:0004386)3.41318818
21Abnormality of T cells (HP:0002843)3.36434498
22Inflammation of the large intestine (HP:0002037)3.35026245
23Colitis (HP:0002583)3.30707135
24Nasal polyposis (HP:0100582)3.29689053
25Abnormality of the fingertips (HP:0001211)3.28477897
26Basal cell carcinoma (HP:0002671)3.27600183
27Encephalitis (HP:0002383)3.24092393
28Gingivitis (HP:0000230)3.20991436
29Hypochromic anemia (HP:0001931)3.17516689
30Pustule (HP:0200039)3.11726348
31Urticaria (HP:0001025)3.05427398
32Lymphopenia (HP:0001888)2.96930814
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.94978581
34Meningitis (HP:0001287)2.90157654
35Eczematoid dermatitis (HP:0000976)2.86436760
36Increased density of long bones (HP:0006392)2.84290976
37Hypochromic microcytic anemia (HP:0004840)2.83327370
38Abnormality of the nasal mucosa (HP:0000433)2.76712762
39Recurrent cutaneous fungal infections (HP:0011370)2.73676706
40Chronic mucocutaneous candidiasis (HP:0002728)2.73676706
41Epistaxis (HP:0000421)2.70897714
42B lymphocytopenia (HP:0010976)2.70605961
43Abnormality of B cell number (HP:0010975)2.70605961
44Petechiae (HP:0000967)2.70128320
45Gastrointestinal stroma tumor (HP:0100723)2.68354059
46Abnormality of T cell physiology (HP:0011840)2.66023050
47Recurrent sinusitis (HP:0011108)2.64340528
48Keratoconjunctivitis sicca (HP:0001097)2.64156528
49Emphysema (HP:0002097)2.60720454
50Recurrent abscess formation (HP:0002722)2.56410995
51Combined immunodeficiency (HP:0005387)2.54936258
52Thrombocytosis (HP:0001894)2.51363320
53Increased IgM level (HP:0003496)2.50962671
54Hyperacusis (HP:0010780)2.43473066
55Elevated erythrocyte sedimentation rate (HP:0003565)2.42719625
56Increased IgE level (HP:0003212)2.40234931
57Spontaneous hematomas (HP:0007420)2.39645265
58Thyroiditis (HP:0100646)2.39106846
59Keratoconjunctivitis (HP:0001096)2.36622753
60Anorexia (HP:0002039)2.35987145
61Arterial thrombosis (HP:0004420)2.35839868
62IgA deficiency (HP:0002720)2.34047303
63Chronic sinusitis (HP:0011109)2.32911302
64Pulmonary infiltrates (HP:0002113)2.32011978
65Abnormal platelet volume (HP:0011876)2.31362655
66IgG deficiency (HP:0004315)2.29802016
67Slow saccadic eye movements (HP:0000514)2.28207073
68Hemoptysis (HP:0002105)2.28196607
69Mediastinal lymphadenopathy (HP:0100721)2.27474772
70Gingival bleeding (HP:0000225)2.26987594
71Increased serum ferritin (HP:0003281)2.26508755
72Hypertensive crisis (HP:0100735)2.24781884
73Cerebral aneurysm (HP:0004944)2.24441395
74Lymphoma (HP:0002665)2.23498336
75Severe combined immunodeficiency (HP:0004430)2.23135812
76Microcytic anemia (HP:0001935)2.22945308
77Purpura (HP:0000979)2.20788451
78Autoimmune thrombocytopenia (HP:0001973)2.19288561
79Episodic fever (HP:0001954)2.17574093
80Bronchitis (HP:0012387)2.12556268
81Vasculitis (HP:0002633)2.12049790
82Ulnar bowing (HP:0003031)2.09341506
83Recurrent bacterial skin infections (HP:0005406)2.08695287
84Short 4th metacarpal (HP:0010044)2.08641897
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08641897
86Increased cerebral lipofuscin (HP:0011813)2.08522166
87Prolonged bleeding time (HP:0003010)2.07432085
88Abnormality of oral frenula (HP:0000190)2.03846024
89Abnormality of cells of the erythroid lineage (HP:0012130)2.02872070
90Vertebral arch anomaly (HP:0008438)2.02507608
91Hepatosplenomegaly (HP:0001433)2.01724073
92Pulmonary embolism (HP:0002204)2.00765661
93Hypergammaglobulinemia (HP:0010702)2.00190973
94Ependymoma (HP:0002888)1.99417289
95Obstructive lung disease (HP:0006536)1.98468496
96Chronic obstructive pulmonary disease (HP:0006510)1.98468496
97Osteomyelitis (HP:0002754)1.97408560
98Abnormality of iron homeostasis (HP:0011031)1.96178749
99Prominent nose (HP:0000448)1.95880788
100High pitched voice (HP:0001620)1.92836146
101Recurrent skin infections (HP:0001581)1.91630831
102Viral hepatitis (HP:0006562)1.91374101
103Chest pain (HP:0100749)1.91017415
104Heterotopia (HP:0002282)1.90527860
105Restrictive lung disease (HP:0002091)1.90357800
106Autoimmune hemolytic anemia (HP:0001890)1.89125522
107Cutaneous melanoma (HP:0012056)1.88635485
108Stomatitis (HP:0010280)1.87040512
109Broad palm (HP:0001169)1.87027797
110Recurrent otitis media (HP:0000403)1.87004801
111Skin ulcer (HP:0200042)1.85867460
112Eosinophilia (HP:0001880)1.85707961
113Acute hepatic failure (HP:0006554)1.85581426
114Increased mean platelet volume (HP:0011877)1.85355588
115Abnormality of the peritoneum (HP:0002585)1.84530620
116Bicuspid aortic valve (HP:0001647)1.84127653
117Premature loss of primary teeth (HP:0006323)1.84018707
118Glomerulopathy (HP:0100820)1.83739649
119Segmental peripheral demyelination/remyelination (HP:0003481)1.83415804
120Myositis (HP:0100614)1.83411914
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.83378672
122Reticulocytopenia (HP:0001896)1.81884834
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.79654003
124Polycythemia (HP:0001901)1.79185291
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.78892285
126Sepsis (HP:0100806)1.77927208
127Abnormal number of erythroid precursors (HP:0012131)1.77548039
128Subacute progressive viral hepatitis (HP:0006572)1.77101326
129Leukocytosis (HP:0001974)1.76640178
130Skin rash (HP:0000988)1.74650700
131Metaphyseal cupping (HP:0003021)1.74329150
132Macroorchidism (HP:0000053)1.73714184
133Deviation of the thumb (HP:0009603)1.73099700
134Recurrent lower respiratory tract infections (HP:0002783)1.71632987
135Granulocytopenia (HP:0001913)1.70379253
136Amaurosis fugax (HP:0100576)1.68390215
137Poikiloderma (HP:0001029)1.68134355
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67146658
139Fatigue (HP:0012378)1.65540406
140Proximal placement of thumb (HP:0009623)1.65426458
141Persistence of primary teeth (HP:0006335)1.65025508
142Abnormality of eosinophils (HP:0001879)1.64393166
143Interstitial pulmonary disease (HP:0006530)1.64304529
144Spinal cord lesions (HP:0100561)1.63845650
145Syringomyelia (HP:0003396)1.63845650
146Dilatation of the ascending aorta (HP:0005111)1.61975353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.48661542
2MAP3K103.85999792
3EEF2K3.83653309
4PRPF4B3.51227408
5PKN23.23940799
6TRIB32.94375358
7STK102.73726230
8SMG12.44238705
9CDK122.18606707
10LRRK22.01123701
11JAK31.89565118
12ZAP701.80239883
13SIK21.79143558
14NEK21.72956815
15ITK1.71236597
16TYK21.70536908
17BTK1.64442722
18MAP3K31.62631851
19BLK1.61015172
20TXK1.54545816
21CDC71.54247080
22ERN11.49497849
23SYK1.48037970
24ALK1.46210974
25TTN1.45415922
26SIK31.41815790
27FGFR41.39572080
28IRAK31.30565293
29TAOK21.30536013
30CDK41.30088072
31MAP3K131.27688958
32HCK1.27652421
33CSF1R1.26935027
34MAP3K11.25141806
35CSK1.24060658
36KSR21.22007357
37JAK11.21248155
38CLK11.20445149
39TESK21.18611078
40PIM11.18141422
41LCK1.15379433
42RPS6KB21.13627896
43FGFR31.12439086
44MAP3K81.09180832
45FGR1.08785367
46SCYL21.07375059
47* GRK61.07284333
48MARK31.06669013
49PTK61.06058250
50RPS6KA41.05925484
51MAP2K31.04487470
52ICK1.01740702
53IRAK21.01417281
54TBK10.97455880
55PRKCH0.95080868
56IKBKE0.90418638
57FES0.89969930
58FLT30.89350030
59PDPK10.87339228
60TNK20.86618924
61STK40.85192491
62PASK0.80112001
63MAPK120.79232397
64TEC0.78381110
65MAP3K140.77532009
66TAOK10.77313837
67BRD40.73280538
68TGFBR10.71782830
69CDK60.71411047
70YES10.67383273
71LYN0.67375702
72JAK20.67262839
73MAP3K70.66981605
74RIPK10.66747273
75CDC42BPA0.66233345
76MELK0.64927921
77MAP2K20.63289323
78CAMKK10.62465038
79EPHB10.61490794
80RIPK40.61424172
81BMX0.59237754
82IKBKB0.58481496
83IRAK10.58468143
84PDK10.58260530
85TAOK30.56759187
86TYRO30.56648704
87NLK0.55008294
88ATR0.54651127
89CHEK10.54309392
90PRKD20.54222861
91TSSK60.52480819
92PRKCQ0.52365862
93MST40.51571397
94MTOR0.51555422
95HIPK20.51179833
96BUB10.50878953
97MAP3K60.50586773
98KIT0.50549654
99TLK10.50446073
100MATK0.50309439
101CDK90.49252222
102RPS6KA20.49064551
103MAPK110.48827243
104SIK10.47990639
105TGFBR20.47697380
106NME20.47212913
107BMPR20.46137144
108RAF10.45969399
109MAP3K20.45008321
110FYN0.44661656
111RPS6KA60.44645845
112PAK40.44446099
113SGK30.43896905
114RPS6KC10.43157959
115RPS6KL10.43157959
116MAPK70.41581943
117CDK20.41299713
118CDK70.40452970
119MAPKAPK20.40066593
120DYRK1B0.39885077
121WEE10.39806594
122PDGFRB0.38023920
123IRAK40.37597498
124KDR0.36995054
125CHUK0.36836973
126CAMK1D0.36756572
127MAP3K110.36338299
128RET0.35815738
129AURKB0.35455001
130STK110.35408599
131RPS6KA10.33843828
132MARK20.33583038

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.97621641
2B cell receptor signaling pathway_Homo sapiens_hsa046622.95961057
3T cell receptor signaling pathway_Homo sapiens_hsa046602.32392541
4DNA replication_Homo sapiens_hsa030302.13644625
5Allograft rejection_Homo sapiens_hsa053302.02357603
6Graft-versus-host disease_Homo sapiens_hsa053321.99122146
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97705444
8Antigen processing and presentation_Homo sapiens_hsa046121.94605233
9Autoimmune thyroid disease_Homo sapiens_hsa053201.89412927
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86757878
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86713831
12Staphylococcus aureus infection_Homo sapiens_hsa051501.84479906
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.78509041
14Osteoclast differentiation_Homo sapiens_hsa043801.74677526
15Mismatch repair_Homo sapiens_hsa034301.71420080
16Chronic myeloid leukemia_Homo sapiens_hsa052201.66574706
17Leishmaniasis_Homo sapiens_hsa051401.65983741
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65621111
19Measles_Homo sapiens_hsa051621.65393597
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.61998976
21Hematopoietic cell lineage_Homo sapiens_hsa046401.60337175
22Base excision repair_Homo sapiens_hsa034101.58525692
23Other glycan degradation_Homo sapiens_hsa005111.58075115
24Acute myeloid leukemia_Homo sapiens_hsa052211.54338692
25Spliceosome_Homo sapiens_hsa030401.50802798
26Non-small cell lung cancer_Homo sapiens_hsa052231.47444192
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.43298865
28Malaria_Homo sapiens_hsa051441.41692829
29Herpes simplex infection_Homo sapiens_hsa051681.36846777
30Type I diabetes mellitus_Homo sapiens_hsa049401.32322947
31Ribosome_Homo sapiens_hsa030101.32152820
32Hepatitis B_Homo sapiens_hsa051611.29640272
33Viral carcinogenesis_Homo sapiens_hsa052031.29379672
34Viral myocarditis_Homo sapiens_hsa054161.29186568
35HTLV-I infection_Homo sapiens_hsa051661.28103163
36Shigellosis_Homo sapiens_hsa051311.24108498
37Pancreatic cancer_Homo sapiens_hsa052121.22904766
38Colorectal cancer_Homo sapiens_hsa052101.22453240
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22029530
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.20971687
41RNA transport_Homo sapiens_hsa030131.20675599
42Platelet activation_Homo sapiens_hsa046111.20548657
43mRNA surveillance pathway_Homo sapiens_hsa030151.20180386
44Cell cycle_Homo sapiens_hsa041101.18830383
45VEGF signaling pathway_Homo sapiens_hsa043701.16787736
46Toxoplasmosis_Homo sapiens_hsa051451.16615732
47Epstein-Barr virus infection_Homo sapiens_hsa051691.15848559
48mTOR signaling pathway_Homo sapiens_hsa041501.15744605
49* Chemokine signaling pathway_Homo sapiens_hsa040621.13950212
50Apoptosis_Homo sapiens_hsa042101.11768119
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.11183590
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10046601
53Small cell lung cancer_Homo sapiens_hsa052221.02955612
54Asthma_Homo sapiens_hsa053100.99569127
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99388090
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98205761
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97750809
58p53 signaling pathway_Homo sapiens_hsa041150.96332063
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93604868
60Non-homologous end-joining_Homo sapiens_hsa034500.92798978
61Influenza A_Homo sapiens_hsa051640.92558056
62Phagosome_Homo sapiens_hsa041450.91559455
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90718038
64One carbon pool by folate_Homo sapiens_hsa006700.89998884
65Endometrial cancer_Homo sapiens_hsa052130.87503040
66MicroRNAs in cancer_Homo sapiens_hsa052060.87122154
67Notch signaling pathway_Homo sapiens_hsa043300.86267093
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85086153
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84681155
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84558218
71African trypanosomiasis_Homo sapiens_hsa051430.83871095
72Systemic lupus erythematosus_Homo sapiens_hsa053220.83477885
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82324851
74Tuberculosis_Homo sapiens_hsa051520.79394076
75Glioma_Homo sapiens_hsa052140.78448020
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.78249448
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76675246
78Nucleotide excision repair_Homo sapiens_hsa034200.75539428
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75528593
80TNF signaling pathway_Homo sapiens_hsa046680.75527194
81Proteoglycans in cancer_Homo sapiens_hsa052050.75195809
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75094059
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74997267
84Prolactin signaling pathway_Homo sapiens_hsa049170.74103341
85Thyroid cancer_Homo sapiens_hsa052160.73557078
86Choline metabolism in cancer_Homo sapiens_hsa052310.73512493
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70762652
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.70589992
89Homologous recombination_Homo sapiens_hsa034400.69037630
90FoxO signaling pathway_Homo sapiens_hsa040680.67436112
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.67252779
92Renal cell carcinoma_Homo sapiens_hsa052110.67247543
93HIF-1 signaling pathway_Homo sapiens_hsa040660.67213155
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66726764
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65460765
96Legionellosis_Homo sapiens_hsa051340.65261219
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65125610
98Lysosome_Homo sapiens_hsa041420.64958800
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64610363
100Hepatitis C_Homo sapiens_hsa051600.63727089
101ErbB signaling pathway_Homo sapiens_hsa040120.62649569
102GnRH signaling pathway_Homo sapiens_hsa049120.61979910
103MAPK signaling pathway_Homo sapiens_hsa040100.60537027
104Insulin resistance_Homo sapiens_hsa049310.58361717
105Prostate cancer_Homo sapiens_hsa052150.58215684
106Lysine degradation_Homo sapiens_hsa003100.57459087
107Salmonella infection_Homo sapiens_hsa051320.57188680
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.56511815
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55291288
110Pertussis_Homo sapiens_hsa051330.54387184
111Adherens junction_Homo sapiens_hsa045200.52958166
112Rheumatoid arthritis_Homo sapiens_hsa053230.52798787
113Pentose phosphate pathway_Homo sapiens_hsa000300.52406509
114Estrogen signaling pathway_Homo sapiens_hsa049150.52180377
115Pathways in cancer_Homo sapiens_hsa052000.52062284
116RNA degradation_Homo sapiens_hsa030180.51736298
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51265655
118Inositol phosphate metabolism_Homo sapiens_hsa005620.50760423
119Rap1 signaling pathway_Homo sapiens_hsa040150.49976239
120* Endocytosis_Homo sapiens_hsa041440.49463951
121Bladder cancer_Homo sapiens_hsa052190.48506048
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47902898
123Focal adhesion_Homo sapiens_hsa045100.47848754
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.46853397
125Fructose and mannose metabolism_Homo sapiens_hsa000510.46694895
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44934449
127Insulin signaling pathway_Homo sapiens_hsa049100.44203344
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43147404

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