GRK6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.09225457
2sperm motility (GO:0030317)5.23305032
3fusion of sperm to egg plasma membrane (GO:0007342)5.04675806
4acrosome reaction (GO:0007340)4.80591150
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59402582
6negative regulation of cell killing (GO:0031342)4.59402582
7negative T cell selection (GO:0043383)4.57134860
8chromosome condensation (GO:0030261)4.55446728
9DNA packaging (GO:0006323)4.47036323
10positive regulation of interleukin-4 production (GO:0032753)4.36273672
11positive regulation of T cell mediated cytotoxicity (GO:0001916)4.28437469
12negative thymic T cell selection (GO:0045060)4.28215179
13spermatid nucleus differentiation (GO:0007289)4.24652284
14positive regulation of gamma-delta T cell activation (GO:0046645)4.21780340
15regulation of chronic inflammatory response (GO:0002676)4.18097056
16regulation of interferon-beta biosynthetic process (GO:0045357)4.11686946
17regulation of gamma-delta T cell differentiation (GO:0045586)4.05265047
18sperm-egg recognition (GO:0035036)3.98747394
19regulation of B cell receptor signaling pathway (GO:0050855)3.92418828
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.91683764
21positive regulation of T cell cytokine production (GO:0002726)3.89818924
22protein polyglutamylation (GO:0018095)3.89274517
23single strand break repair (GO:0000012)3.85941439
24microtubule depolymerization (GO:0007019)3.82042362
25regulation of isotype switching to IgG isotypes (GO:0048302)3.77663789
26cellular response to exogenous dsRNA (GO:0071360)3.76669263
27sperm capacitation (GO:0048240)3.73516875
28regulation of T cell mediated cytotoxicity (GO:0001914)3.72482918
29positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.71563306
30B cell receptor signaling pathway (GO:0050853)3.70707039
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67043538
32thymic T cell selection (GO:0045061)3.65532587
33interferon-gamma production (GO:0032609)3.63852317
34regulation of gamma-delta T cell activation (GO:0046643)3.63793721
35rRNA methylation (GO:0031167)3.61705509
36binding of sperm to zona pellucida (GO:0007339)3.61354393
37plasma membrane fusion (GO:0045026)3.61286811
38positive regulation of T cell mediated immunity (GO:0002711)3.61057632
39T cell migration (GO:0072678)3.58263488
40response to pheromone (GO:0019236)3.57325003
41multicellular organism reproduction (GO:0032504)3.55025772
42phosphatidylethanolamine biosynthetic process (GO:0006646)3.54802209
43regulation of interleukin-4 production (GO:0032673)3.51708330
44positive regulation of humoral immune response (GO:0002922)3.48919862
45T cell selection (GO:0045058)3.48667674
46positive thymic T cell selection (GO:0045059)3.48601465
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47679557
48spermatid development (GO:0007286)3.47586602
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45325770
50cell-cell recognition (GO:0009988)3.41967902
51regulation of leukocyte mediated cytotoxicity (GO:0001910)3.41794078
52positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.40800132
53positive regulation of lymphocyte mediated immunity (GO:0002708)3.40384275
54antigen processing and presentation of endogenous antigen (GO:0019883)3.37005834
55positive regulation by symbiont of host defense response (GO:0052509)3.35826831
56modulation by symbiont of host defense response (GO:0052031)3.35826831
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35826831
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35826831
59positive regulation by organism of defense response of other organism involved in symbiotic interact3.35826831
60modulation by symbiont of host immune response (GO:0052553)3.35826831
61positive regulation of cell killing (GO:0031343)3.35346894
62reproduction (GO:0000003)3.34743765
63positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.34600555
64response to host immune response (GO:0052572)3.31508381
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31508381
66B cell mediated immunity (GO:0019724)3.30258280
67sexual reproduction (GO:0019953)3.28597820
68homeostasis of number of cells within a tissue (GO:0048873)3.27886121
69phosphatidylethanolamine metabolic process (GO:0046337)3.27473766
70regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.25684177
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.23941700
72positive regulation of adaptive immune response (GO:0002821)3.23599372
73positive regulation of interferon-gamma production (GO:0032729)3.22240268
74positive regulation of leukocyte mediated immunity (GO:0002705)3.20941350
75positive T cell selection (GO:0043368)3.20169712
76regulation of natural killer cell mediated immunity (GO:0002715)3.15422306
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15422306
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.15214039
79rRNA modification (GO:0000154)3.14784677
80regulation of cell killing (GO:0031341)3.14161887
81positive regulation of chemokine biosynthetic process (GO:0045080)3.12056707
82regulation of lymphocyte mediated immunity (GO:0002706)3.09915914
83negative regulation of stress fiber assembly (GO:0051497)3.09815999
84cellular response to type I interferon (GO:0071357)3.08859951
85type I interferon signaling pathway (GO:0060337)3.08859951
86immunoglobulin mediated immune response (GO:0016064)3.07963919
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07600865
88respiratory burst (GO:0045730)3.06336802
89positive regulation of B cell mediated immunity (GO:0002714)3.04784386
90positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04784386
91regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.04687310
92mitochondrial calcium ion transport (GO:0006851)3.04576279
93lymphocyte chemotaxis (GO:0048247)3.04158240
94response to type I interferon (GO:0034340)3.03985310
95positive regulation of B cell differentiation (GO:0045579)3.03687876
96regulation of T cell mediated immunity (GO:0002709)3.01831663
97positive regulation of interleukin-17 production (GO:0032740)3.01030829
98actin nucleation (GO:0045010)3.00836832
99regulation of defense response to virus by virus (GO:0050690)2.96165629
100antigen receptor-mediated signaling pathway (GO:0050851)2.94969417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61941439
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.06566097
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48136790
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74467310
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73836181
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72845797
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72010730
8RUNX_20019798_ChIP-Seq_JUKART_Human2.68293929
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67599289
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59843194
11MYB_26560356_Chip-Seq_TH2_Human2.51150282
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.38023646
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35196874
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34614050
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.33862662
16ELF1_20517297_ChIP-Seq_JURKAT_Human2.28152729
17UTX_26944678_Chip-Seq_JUKART_Human2.26846727
18BCL6_27268052_Chip-Seq_Bcells_Human2.23727965
19MAF_26560356_Chip-Seq_TH1_Human2.23681276
20MYC_22102868_ChIP-Seq_BL_Human2.20586296
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05817368
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02862998
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02764867
24MAF_26560356_Chip-Seq_TH2_Human2.01302615
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.99720750
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90694026
27BCOR_27268052_Chip-Seq_Bcells_Human1.88486127
28VDR_21846776_ChIP-Seq_THP-1_Human1.88126415
29MYB_26560356_Chip-Seq_TH1_Human1.85540515
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.80273011
31GATA3_27048872_Chip-Seq_THYMUS_Human1.79552182
32P68_20966046_ChIP-Seq_HELA_Human1.78445645
33LXR_22292898_ChIP-Seq_THP-1_Human1.73235920
34VDR_24763502_ChIP-Seq_THP-1_Human1.71239010
35CIITA_25753668_ChIP-Seq_RAJI_Human1.65585625
36ERA_21632823_ChIP-Seq_H3396_Human1.64962512
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63333135
38E2F1_20622854_ChIP-Seq_HELA_Human1.61907040
39SPI1_23547873_ChIP-Seq_NB4_Human1.58915769
40SPI1_23127762_ChIP-Seq_K562_Human1.57785674
41CTCF_20526341_ChIP-Seq_ESCs_Human1.53160646
42SCL_19346495_ChIP-Seq_HPC-7_Human1.52760477
43GATA3_26560356_Chip-Seq_TH2_Human1.52606562
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51097703
45P300_27268052_Chip-Seq_Bcells_Human1.50956694
46NANOG_20526341_ChIP-Seq_ESCs_Human1.42764674
47TAF2_19829295_ChIP-Seq_ESCs_Human1.42498638
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42115345
49PHF8_20622854_ChIP-Seq_HELA_Human1.41886759
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40907198
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.40483484
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35002841
53SPI1_20517297_ChIP-Seq_HL60_Human1.34394352
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34191000
55RAC3_21632823_ChIP-Seq_H3396_Human1.33643161
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.33073752
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32197681
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31399286
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31264522
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30486501
61SA1_27219007_Chip-Seq_Bcells_Human1.29846635
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27176377
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26317098
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24579578
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.24511824
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.24211105
67SMC4_20622854_ChIP-Seq_HELA_Human1.23537955
68OCT4_20526341_ChIP-Seq_ESCs_Human1.19483515
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17435688
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.17374403
71KDM2B_26808549_Chip-Seq_DND41_Human1.15856051
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15353498
73TCF7_22412390_ChIP-Seq_EML_Mouse1.14507232
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14348918
75CTCF_21964334_Chip-Seq_Bcells_Human1.12820055
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12425812
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.12244534
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.11953525
79GATA3_26560356_Chip-Seq_TH1_Human1.09826716
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09295981
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07359971
82VDR_24787735_ChIP-Seq_THP-1_Human1.07295654
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03552612
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03139776
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03116861
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02780073
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02330300
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.01996155
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01227998
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01193143
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00813016
92TP63_22573176_ChIP-Seq_HFKS_Human1.00290242
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.99596632
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98760885
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98235926
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97452373
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97080221
98MYC_19829295_ChIP-Seq_ESCs_Human0.95925060
99SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94927135
100GATA1_19941826_ChIP-Seq_K562_Human0.93740278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.87620561
2MP0000685_abnormal_immune_system4.14202316
3MP0005671_abnormal_response_to4.10695716
4MP0001348_abnormal_lacrimal_gland3.79020791
5MP0001835_abnormal_antigen_presentation3.65729278
6MP0003436_decreased_susceptibility_to3.38807295
7MP0009785_altered_susceptibility_to3.05764565
8MP0005387_immune_system_phenotype2.87266911
9MP0001790_abnormal_immune_system2.87266911
10MP0001800_abnormal_humoral_immune2.80036938
11MP0005000_abnormal_immune_tolerance2.66966152
12MP0005025_abnormal_response_to2.65010703
13MP0002723_abnormal_immune_serum2.42806948
14MP0002420_abnormal_adaptive_immunity2.34573795
15MP0003763_abnormal_thymus_physiology2.32282018
16MP0001819_abnormal_immune_cell2.30354260
17MP0002452_abnormal_antigen_presenting2.28867300
18MP0001873_stomach_inflammation2.20422356
19MP0003172_abnormal_lysosome_physiology2.15017759
20MP0002419_abnormal_innate_immunity2.14502325
21MP0003724_increased_susceptibility_to2.14436403
22MP0006082_CNS_inflammation2.03380625
23MP0002398_abnormal_bone_marrow2.00512560
24MP0002148_abnormal_hypersensitivity_rea2.00253028
25MP0003878_abnormal_ear_physiology1.94629179
26MP0005377_hearing/vestibular/ear_phenot1.94629179
27MP0005310_abnormal_salivary_gland1.93343201
28MP0002405_respiratory_system_inflammati1.90164792
29MP0002166_altered_tumor_susceptibility1.88019267
30MP0000716_abnormal_immune_system1.83646533
31MP0002132_abnormal_respiratory_system1.81130116
32MP0004947_skin_inflammation1.76932982
33MP0000689_abnormal_spleen_morphology1.70571953
34MP0002722_abnormal_immune_system1.69814235
35MP0000703_abnormal_thymus_morphology1.69189409
36MP0002138_abnormal_hepatobiliary_system1.67864509
37MP0003698_abnormal_male_reproductive1.60008895
38MP0009333_abnormal_splenocyte_physiolog1.59801281
39MP0002429_abnormal_blood_cell1.49114306
40MP0001845_abnormal_inflammatory_respons1.48441563
41MP0005645_abnormal_hypothalamus_physiol1.46446114
42MP0001929_abnormal_gametogenesis1.45956798
43MP0005464_abnormal_platelet_physiology1.45040835
44MP0003303_peritoneal_inflammation1.43700579
45MP0005379_endocrine/exocrine_gland_phen1.39095038
46MP0001533_abnormal_skeleton_physiology1.38323304
47MP0009764_decreased_sensitivity_to1.35720232
48MP0005166_decreased_susceptibility_to1.34269056
49MP0003866_abnormal_defecation1.29624463
50MP0002006_tumorigenesis1.28200994
51MP0000678_abnormal_parathyroid_gland1.27303511
52MP0008469_abnormal_protein_level1.24087198
53MP0005670_abnormal_white_adipose1.23402301
54MP0005075_abnormal_melanosome_morpholog1.22987060
55MP0010155_abnormal_intestine_physiology1.20769427
56MP0004381_abnormal_hair_follicle1.15121754
57MP0000465_gastrointestinal_hemorrhage1.08479108
58MP0003045_fibrosis1.01531927
59MP0002653_abnormal_ependyma_morphology0.99287361
60MP0002396_abnormal_hematopoietic_system0.97974356
61MP0002163_abnormal_gland_morphology0.97006918
62MP0003011_delayed_dark_adaptation0.94352794
63MP0004808_abnormal_hematopoietic_stem0.88089408
64MP0000015_abnormal_ear_pigmentation0.85827100
65MP0001501_abnormal_sleep_pattern0.82453144
66MP0002161_abnormal_fertility/fecundity0.79404532
67MP0003191_abnormal_cellular_cholesterol0.79158249
68MP0003448_altered_tumor_morphology0.77483010
69MP0005083_abnormal_biliary_tract0.75712050
70MP0004036_abnormal_muscle_relaxation0.73904232
71MP0003646_muscle_fatigue0.73737776
72MP0001765_abnormal_ion_homeostasis0.71497289
73MP0002928_abnormal_bile_duct0.70550934
74MP0002019_abnormal_tumor_incidence0.69420943
75MP0001764_abnormal_homeostasis0.66835131
76MP0004742_abnormal_vestibular_system0.65178113
77MP0009278_abnormal_bone_marrow0.64823111
78MP0003300_gastrointestinal_ulcer0.64739208
79MP0004510_myositis0.63282711
80MP0003786_premature_aging0.61965618
81MP0002933_joint_inflammation0.59253743
82MP0001905_abnormal_dopamine_level0.59050304
83MP0000490_abnormal_crypts_of0.57760798
84MP0005584_abnormal_enzyme/coenzyme_acti0.56881752
85MP0002693_abnormal_pancreas_physiology0.55453703
86MP0000681_abnormal_thyroid_gland0.54910827
87MP0008874_decreased_physiological_sensi0.54631108
88MP0000249_abnormal_blood_vessel0.53629913
89MP0009763_increased_sensitivity_to0.52213236
90MP0002210_abnormal_sex_determination0.50939343
91MP0003252_abnormal_bile_duct0.47601916
92MP0005319_abnormal_enzyme/_coenzyme0.47019412
93MP0001919_abnormal_reproductive_system0.46040153
94MP0005334_abnormal_fat_pad0.45101570
95MP0003638_abnormal_response/metabolism_0.44638683
96MP0003075_altered_response_to0.44045517
97MP0000470_abnormal_stomach_morphology0.42735980
98MP0001968_abnormal_touch/_nociception0.42625385
99MP0003787_abnormal_imprinting0.42173834
100MP0008995_early_reproductive_senescence0.41106202

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.73200264
2Increased IgM level (HP:0003496)4.36961055
3Myositis (HP:0100614)4.20428512
4Elevated erythrocyte sedimentation rate (HP:0003565)4.09888126
5Gastrointestinal infarctions (HP:0005244)3.91758717
6Recurrent bacterial skin infections (HP:0005406)3.89474145
7Chronic obstructive pulmonary disease (HP:0006510)3.82764809
8Obstructive lung disease (HP:0006536)3.82764809
9Meningitis (HP:0001287)3.74691514
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.73387058
11IgG deficiency (HP:0004315)3.57354796
12Retrobulbar optic neuritis (HP:0100654)3.43891774
13Optic neuritis (HP:0100653)3.43891774
14Recurrent abscess formation (HP:0002722)3.38988072
15Agammaglobulinemia (HP:0004432)3.36299594
16Abnormality of T cell physiology (HP:0011840)3.31906013
17Encephalitis (HP:0002383)3.29661624
18Abnormality of macrophages (HP:0004311)3.25681917
19Abnormality of T cells (HP:0002843)3.17794977
20Renal Fanconi syndrome (HP:0001994)3.16056890
21Recurrent fungal infections (HP:0002841)3.11995944
22Abnormality of T cell number (HP:0011839)3.11517313
23Eczematoid dermatitis (HP:0000976)3.11427714
24Eosinophilia (HP:0001880)3.10194796
25Orchitis (HP:0100796)3.04821747
26Vasculitis (HP:0002633)3.02410209
27Nasal polyposis (HP:0100582)3.01629262
28Granulocytopenia (HP:0001913)2.99585717
29Attenuation of retinal blood vessels (HP:0007843)2.95556024
30Chest pain (HP:0100749)2.93392476
31Autoimmune thrombocytopenia (HP:0001973)2.88169104
32Abnormal rod and cone electroretinograms (HP:0008323)2.85966809
33Mediastinal lymphadenopathy (HP:0100721)2.84729216
34Stomatitis (HP:0010280)2.80250548
35Recurrent bronchitis (HP:0002837)2.77072288
36T lymphocytopenia (HP:0005403)2.76568085
37Hemoptysis (HP:0002105)2.74688339
38Recurrent skin infections (HP:0001581)2.68975476
39Autoimmune hemolytic anemia (HP:0001890)2.68889424
40Joint swelling (HP:0001386)2.68064566
41Recurrent viral infections (HP:0004429)2.60900469
42Hypertensive crisis (HP:0100735)2.53939720
43Abnormality of eosinophils (HP:0001879)2.52338605
44Recurrent pneumonia (HP:0006532)2.51851580
45Seborrheic dermatitis (HP:0001051)2.42738537
46Verrucae (HP:0200043)2.42015288
47Papilloma (HP:0012740)2.42015288
48Hyperkalemia (HP:0002153)2.41407788
49Cellulitis (HP:0100658)2.41102373
50Recurrent gram-negative bacterial infections (HP:0005420)2.39474497
51Hypochromic anemia (HP:0001931)2.39315343
52Hypoproteinemia (HP:0003075)2.38041061
53Arterial thrombosis (HP:0004420)2.36595072
54Pulmonary infiltrates (HP:0002113)2.34727665
55Leukocytosis (HP:0001974)2.34262680
56Abnormality of the nasal mucosa (HP:0000433)2.34173932
57Anorexia (HP:0002039)2.33530198
58Absent/shortened dynein arms (HP:0200106)2.31567779
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.31567779
60Exertional dyspnea (HP:0002875)2.28147907
61Menstrual irregularities (HP:0000858)2.25140863
62Fatigue (HP:0012378)2.24829178
63Recurrent lower respiratory tract infections (HP:0002783)2.24065021
64Prolonged bleeding time (HP:0003010)2.21602108
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.20059299
66Bony spicule pigmentary retinopathy (HP:0007737)2.19310825
67Keratoconjunctivitis sicca (HP:0001097)2.18454888
68Truncus arteriosus (HP:0001660)2.17880741
69IgM deficiency (HP:0002850)2.16786715
70Enlarged epiphyses (HP:0010580)2.16128547
71Urticaria (HP:0001025)2.15410803
72Supernumerary ribs (HP:0005815)2.14340476
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14016356
74Generalized aminoaciduria (HP:0002909)2.13354254
75Polydipsia (HP:0001959)2.13315976
76Abnormal drinking behavior (HP:0030082)2.13315976
77Glomerulopathy (HP:0100820)2.12717126
78Abnormal biliary tract physiology (HP:0012439)2.12594136
79Bile duct proliferation (HP:0001408)2.12594136
80Increased intramyocellular lipid droplets (HP:0012240)2.12150625
81Abnormality of the aortic arch (HP:0012303)2.11737501
82Chronic sinusitis (HP:0011109)2.11472042
83Pulmonary fibrosis (HP:0002206)2.08885076
84Cerebral palsy (HP:0100021)2.08408063
85Keratoconjunctivitis (HP:0001096)2.06966291
86Hypergammaglobulinemia (HP:0010702)2.06679864
87Abnormality of the prostate (HP:0008775)2.06546932
88Gangrene (HP:0100758)2.05887232
89Lymphopenia (HP:0001888)2.04471861
90Amaurosis fugax (HP:0100576)2.01768350
91Panhypogammaglobulinemia (HP:0003139)1.96710322
92Hypoplasia of the thymus (HP:0000778)1.95939290
93Male infertility (HP:0003251)1.92658544
94Inflammation of the large intestine (HP:0002037)1.92599924
95Prostate neoplasm (HP:0100787)1.91953540
96Abnormality of the peritoneum (HP:0002585)1.88822428
97Chronic hepatic failure (HP:0100626)1.87833664
98Lymphoma (HP:0002665)1.86039565
99Abnormal urine output (HP:0012590)1.85398462
100Bronchitis (HP:0012387)1.85337106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK64.35346326
2SIK24.15026712
3MAP4K13.72260254
4TESK13.20696477
5PLK43.20462496
6MAP4K23.11763748
7TESK22.99099972
8TXK2.57897564
9KDR2.55119435
10NUAK12.15702820
11MAP3K112.14833152
12VRK21.95836478
13BRD41.94757072
14RIPK41.93333343
15MAPKAPK31.92399553
16BLK1.82458273
17IRAK41.73312665
18IKBKB1.69590270
19TBK11.69350956
20JAK31.64339304
21MAPK111.51555442
22SMG11.50933848
23DDR21.50223530
24TNK21.49287252
25MAP3K141.47905036
26FES1.42658564
27TAOK31.41852673
28ZAP701.41608395
29PIK3CG1.41580664
30MAP2K21.36799231
31IKBKE1.34881887
32SRPK11.34155827
33SYK1.29114808
34TEC1.27578687
35SIK31.26584074
36BTK1.19232592
37LCK1.13921452
38CDK41.12759224
39ITK1.10781787
40NEK21.09880586
41TRIM281.02790242
42KIT0.95265745
43LYN0.93608237
44INSRR0.90907615
45TLK10.90793651
46DAPK10.90425161
47CSK0.89522132
48BMPR20.89427880
49TAF10.85624879
50WNK10.81937358
51CDK120.80770715
52TAOK20.78875046
53PDK10.76121365
54CDK30.76042634
55CDK70.74063904
56HCK0.69737099
57MAP3K30.68446953
58PRKCQ0.67261697
59STK380.67129505
60MAPK150.66372325
61TRIB30.62519497
62CSF1R0.61438018
63MAP2K60.61131080
64RPS6KA60.60245003
65RPS6KA20.58979785
66MAP2K30.58734291
67RPS6KC10.56890717
68RPS6KL10.56890717
69MAP3K130.55706445
70PRKD30.54117168
71NEK60.53105983
72PDPK10.51589604
73CAMK1D0.49507397
74TYK20.45089305
75MAPKAPK20.42437417
76TAOK10.42335326
77ERN10.42210999
78NME10.40532803
79CAMKK20.40063836
80RPS6KA10.38755106
81SCYL20.37916703
82CAMK1G0.37061404
83MAP3K10.36980736
84MAP3K20.36942818
85MARK30.36727889
86CSNK1G30.36619023
87PIM10.35334016
88TRPM70.34433248
89MATK0.34057784
90KSR20.33829605
91CHUK0.32886275
92EIF2AK30.31564621
93MAPK120.31374401
94FYN0.30765706
95ILK0.30252410
96EIF2AK20.29160140
97RAF10.28911052
98MAPK40.26943575
99PASK0.26451595
100EEF2K0.25081338

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.59306959
2Allograft rejection_Homo sapiens_hsa053304.38291588
3Antigen processing and presentation_Homo sapiens_hsa046124.20294997
4Autoimmune thyroid disease_Homo sapiens_hsa053204.16306335
5Asthma_Homo sapiens_hsa053103.92671586
6Type I diabetes mellitus_Homo sapiens_hsa049403.85464282
7Primary immunodeficiency_Homo sapiens_hsa053403.72474391
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.56163473
9Hematopoietic cell lineage_Homo sapiens_hsa046402.37674366
10B cell receptor signaling pathway_Homo sapiens_hsa046622.32571773
11Leishmaniasis_Homo sapiens_hsa051402.30173391
12Viral myocarditis_Homo sapiens_hsa054162.27869359
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.18989283
14T cell receptor signaling pathway_Homo sapiens_hsa046602.07200360
15Herpes simplex infection_Homo sapiens_hsa051681.96332926
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.84316685
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80723375
18Measles_Homo sapiens_hsa051621.76045594
19Osteoclast differentiation_Homo sapiens_hsa043801.51572029
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47803576
21Staphylococcus aureus infection_Homo sapiens_hsa051501.44535962
22Influenza A_Homo sapiens_hsa051641.38168974
23Proteasome_Homo sapiens_hsa030501.37707457
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35589964
25Epstein-Barr virus infection_Homo sapiens_hsa051691.22869119
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.18369129
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18241136
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17781051
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17235670
30Tuberculosis_Homo sapiens_hsa051521.10804904
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10535260
32Toxoplasmosis_Homo sapiens_hsa051451.07537520
33Rheumatoid arthritis_Homo sapiens_hsa053231.06962709
34Malaria_Homo sapiens_hsa051441.00998756
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00360645
36Acute myeloid leukemia_Homo sapiens_hsa052210.96429140
37TNF signaling pathway_Homo sapiens_hsa046680.94045151
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86649086
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85089807
40Olfactory transduction_Homo sapiens_hsa047400.80201605
41HTLV-I infection_Homo sapiens_hsa051660.78909310
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77222074
43Legionellosis_Homo sapiens_hsa051340.76484216
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76421460
45Viral carcinogenesis_Homo sapiens_hsa052030.75434002
46Apoptosis_Homo sapiens_hsa042100.75196702
47Regulation of autophagy_Homo sapiens_hsa041400.74806838
48Chemokine signaling pathway_Homo sapiens_hsa040620.74156735
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71236809
50Hepatitis B_Homo sapiens_hsa051610.69771320
51Shigellosis_Homo sapiens_hsa051310.69473318
52African trypanosomiasis_Homo sapiens_hsa051430.67187860
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.64131646
54Phagosome_Homo sapiens_hsa041450.61567683
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56707055
56Endocytosis_Homo sapiens_hsa041440.55214126
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.45479504
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.41399377
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40795100
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40110170
61Base excision repair_Homo sapiens_hsa034100.39785321
62Platelet activation_Homo sapiens_hsa046110.39081658
63Caffeine metabolism_Homo sapiens_hsa002320.38878657
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37897468
65Fatty acid biosynthesis_Homo sapiens_hsa000610.37080776
66Dorso-ventral axis formation_Homo sapiens_hsa043200.37039019
67Non-small cell lung cancer_Homo sapiens_hsa052230.37025669
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35749179
69Systemic lupus erythematosus_Homo sapiens_hsa053220.34613949
70Inositol phosphate metabolism_Homo sapiens_hsa005620.32472521
71Spliceosome_Homo sapiens_hsa030400.29592329
72Salmonella infection_Homo sapiens_hsa051320.28188727
73Hepatitis C_Homo sapiens_hsa051600.28069242
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27750252
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.26505625
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25777353
77MAPK signaling pathway_Homo sapiens_hsa040100.25301585
78N-Glycan biosynthesis_Homo sapiens_hsa005100.24241919
79Salivary secretion_Homo sapiens_hsa049700.23712856
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23208396
81RNA transport_Homo sapiens_hsa030130.22602605
82DNA replication_Homo sapiens_hsa030300.20553574
83Pancreatic cancer_Homo sapiens_hsa052120.19095776
84Morphine addiction_Homo sapiens_hsa050320.18639757
85Nitrogen metabolism_Homo sapiens_hsa009100.18270226
86Lysosome_Homo sapiens_hsa041420.18127454
87Purine metabolism_Homo sapiens_hsa002300.16933580
88VEGF signaling pathway_Homo sapiens_hsa043700.15176830
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15055580
90Pertussis_Homo sapiens_hsa051330.15024189
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14563303
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.11585269
93Pyrimidine metabolism_Homo sapiens_hsa002400.11157287
94Homologous recombination_Homo sapiens_hsa034400.10338815
95Type II diabetes mellitus_Homo sapiens_hsa049300.10104257
96Prolactin signaling pathway_Homo sapiens_hsa049170.09092181
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07636863
98Oxytocin signaling pathway_Homo sapiens_hsa049210.06175086
99Chronic myeloid leukemia_Homo sapiens_hsa052200.05992820
100Nucleotide excision repair_Homo sapiens_hsa034200.05224156

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