GRM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.56682291
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28361737
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.86409741
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.79739955
5regulation of glutamate receptor signaling pathway (GO:1900449)5.71441076
6synaptic vesicle maturation (GO:0016188)5.68388398
7vocalization behavior (GO:0071625)5.63505726
8locomotory exploration behavior (GO:0035641)5.42579651
9* glutamate secretion (GO:0014047)5.40606112
10pyrimidine nucleobase catabolic process (GO:0006208)5.30445261
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.25960235
12synaptic vesicle exocytosis (GO:0016079)5.21535640
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.19282643
14protein localization to synapse (GO:0035418)5.10592791
15ionotropic glutamate receptor signaling pathway (GO:0035235)5.02968366
16neurotransmitter-gated ion channel clustering (GO:0072578)4.96456343
17dendritic spine morphogenesis (GO:0060997)4.83488254
18regulation of neuronal synaptic plasticity (GO:0048168)4.74526996
19* glutamate receptor signaling pathway (GO:0007215)4.74027246
20regulation of synaptic vesicle exocytosis (GO:2000300)4.69389722
21neuron cell-cell adhesion (GO:0007158)4.64366730
22exploration behavior (GO:0035640)4.64355325
23behavioral response to nicotine (GO:0035095)4.62603326
24synaptic transmission, glutamatergic (GO:0035249)4.57437437
25neuronal ion channel clustering (GO:0045161)4.52444912
26cell migration in hindbrain (GO:0021535)4.52369964
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.46654066
28regulation of synaptic vesicle transport (GO:1902803)4.42329956
29neuronal action potential propagation (GO:0019227)4.39075302
30nucleobase catabolic process (GO:0046113)4.30956105
31long-term memory (GO:0007616)4.29251110
32axonal fasciculation (GO:0007413)4.12325328
33cerebellar Purkinje cell differentiation (GO:0021702)4.11630906
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.05450727
35neuron recognition (GO:0008038)4.04721524
36neuron-neuron synaptic transmission (GO:0007270)4.02531895
37neuromuscular synaptic transmission (GO:0007274)3.99550817
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92289928
39layer formation in cerebral cortex (GO:0021819)3.89599529
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.88203539
41neurotransmitter secretion (GO:0007269)3.87225612
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.87224555
43positive regulation of membrane potential (GO:0045838)3.83828983
44regulation of postsynaptic membrane potential (GO:0060078)3.83640425
45dendritic spine organization (GO:0097061)3.83197712
46central nervous system projection neuron axonogenesis (GO:0021952)3.82247480
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.81575917
48positive regulation of synapse maturation (GO:0090129)3.80665034
49regulation of synaptic plasticity (GO:0048167)3.75968911
50membrane depolarization during action potential (GO:0086010)3.74888421
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73581479
52postsynaptic membrane organization (GO:0001941)3.66096106
53* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65082976
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.64395801
55synaptic vesicle endocytosis (GO:0048488)3.61607394
56proline transport (GO:0015824)3.61181816
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55526602
58dendrite morphogenesis (GO:0048813)3.55002716
59regulation of synapse structural plasticity (GO:0051823)3.54471418
60regulation of dendritic spine morphogenesis (GO:0061001)3.53984483
61cellular potassium ion homeostasis (GO:0030007)3.53929127
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.52966892
63presynaptic membrane assembly (GO:0097105)3.52697052
64cellular sodium ion homeostasis (GO:0006883)3.51959258
65gamma-aminobutyric acid transport (GO:0015812)3.51464038
66membrane depolarization (GO:0051899)3.43552482
67adult walking behavior (GO:0007628)3.42227277
68establishment of mitochondrion localization (GO:0051654)3.41772618
69regulation of voltage-gated calcium channel activity (GO:1901385)3.41045293
70regulation of neurotransmitter secretion (GO:0046928)3.36541405
71response to auditory stimulus (GO:0010996)3.34639892
72negative regulation of hormone biosynthetic process (GO:0032353)3.34164279
73negative regulation of hormone metabolic process (GO:0032351)3.34164279
74spinal cord association neuron differentiation (GO:0021527)3.31874812
75righting reflex (GO:0060013)3.31425916
76behavioral defense response (GO:0002209)3.28443561
77behavioral fear response (GO:0001662)3.28443561
78chemosensory behavior (GO:0007635)3.27536936
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.26750104
80regulation of vesicle fusion (GO:0031338)3.25839419
81* regulation of synaptic transmission, glutamatergic (GO:0051966)3.25067004
82presynaptic membrane organization (GO:0097090)3.24948854
83positive regulation of dendritic spine development (GO:0060999)3.24258975
84activation of protein kinase A activity (GO:0034199)3.23731686
85cerebral cortex neuron differentiation (GO:0021895)3.22532314
86urinary tract smooth muscle contraction (GO:0014848)3.21717617
87long-term synaptic potentiation (GO:0060291)3.20284629
88establishment of nucleus localization (GO:0040023)3.20237806
89cell communication by electrical coupling (GO:0010644)3.17339337
90neurotransmitter transport (GO:0006836)3.16121833
91positive regulation of neurotransmitter secretion (GO:0001956)3.16007057
92regulation of dendritic spine development (GO:0060998)3.14549006
93transmission of nerve impulse (GO:0019226)3.14356353
94sodium ion export (GO:0071436)3.14010497
95synapse assembly (GO:0007416)3.13986253
96positive regulation of neurotransmitter transport (GO:0051590)3.13558779
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12508270
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11344766
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10489399
100L-amino acid import (GO:0043092)3.09580768
101cerebellar granule cell differentiation (GO:0021707)3.09017493
102auditory behavior (GO:0031223)3.07439915
103serotonin metabolic process (GO:0042428)3.07097593
104fear response (GO:0042596)3.06870348
105neuromuscular process controlling balance (GO:0050885)3.06359778
106establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05124538
107mitochondrion transport along microtubule (GO:0047497)3.05124538
108negative regulation of dendrite development (GO:2000171)3.03545024
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02898367
110central nervous system myelination (GO:0022010)3.02615498
111axon ensheathment in central nervous system (GO:0032291)3.02615498
112learning (GO:0007612)3.01758616
113* regulation of synaptic transmission (GO:0050804)3.01418001
114peristalsis (GO:0030432)3.01329606
115substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.00966645
116substrate-independent telencephalic tangential migration (GO:0021826)3.00966645
117intraspecies interaction between organisms (GO:0051703)3.00690029
118social behavior (GO:0035176)3.00690029
119regulation of neurotransmitter transport (GO:0051588)2.99133397
120regulation of synapse maturation (GO:0090128)2.98743055
121* synaptic transmission (GO:0007268)2.97441263
122cochlea development (GO:0090102)2.96070539
123regulation of ARF protein signal transduction (GO:0032012)2.95760582
124neuromuscular process controlling posture (GO:0050884)2.93898466
125response to histamine (GO:0034776)2.92093070
126negative regulation of amino acid transport (GO:0051956)2.90647150
127mechanosensory behavior (GO:0007638)2.89913410
128behavioral response to cocaine (GO:0048148)2.89206267
129innervation (GO:0060384)2.88973981
130regulation of neurotransmitter levels (GO:0001505)2.88953295
131central nervous system neuron axonogenesis (GO:0021955)2.86893347
132behavioral response to ethanol (GO:0048149)2.82997195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.96422842
2GBX2_23144817_ChIP-Seq_PC3_Human3.71951492
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00817614
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94052001
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81017851
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60746959
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60746959
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.57101743
9REST_21632747_ChIP-Seq_MESCs_Mouse2.55871907
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49353124
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49124129
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40387366
13DROSHA_22980978_ChIP-Seq_HELA_Human2.38578240
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37741854
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33432520
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.29728217
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.27772016
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.22293667
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21738419
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21628563
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12532793
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08918507
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.07625388
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04917468
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01131687
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97730959
27* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90006756
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75150421
29AR_21572438_ChIP-Seq_LNCaP_Human1.74735459
30SMAD4_21799915_ChIP-Seq_A2780_Human1.73010014
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.72183855
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71532144
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71274549
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69298225
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54370918
36TAF15_26573619_Chip-Seq_HEK293_Human1.50461820
37RNF2_27304074_Chip-Seq_NSC_Mouse1.44184333
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43654521
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43220294
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.42859992
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42004017
42P300_19829295_ChIP-Seq_ESCs_Human1.37985398
43IGF1R_20145208_ChIP-Seq_DFB_Human1.37940617
44STAT3_23295773_ChIP-Seq_U87_Human1.37620700
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34310189
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31350568
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31324068
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31115847
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.30820715
50AR_25329375_ChIP-Seq_VCAP_Human1.30349615
51CTCF_27219007_Chip-Seq_Bcells_Human1.30146643
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30125065
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.30097915
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29833293
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29281714
56ZNF274_21170338_ChIP-Seq_K562_Hela1.26608430
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.26257548
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.25983124
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24806488
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24526405
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23127780
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23127780
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.22858221
64* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18804261
65FUS_26573619_Chip-Seq_HEK293_Human1.18599283
66TCF4_23295773_ChIP-Seq_U87_Human1.17982871
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17141715
68AR_19668381_ChIP-Seq_PC3_Human1.16591981
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16198518
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15473335
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.14456271
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14238682
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14038238
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13368219
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13208483
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13179353
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12034859
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10759980
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10319081
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09960127
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09043740
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07243374
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.06397082
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06150208
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05994781
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.04933220
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04748416
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.04177975
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.03033032
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01867290
91AHR_22903824_ChIP-Seq_MCF-7_Human1.01486027
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00653487
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00227557
94RUNX2_22187159_ChIP-Seq_PCA_Human0.99308198
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99099607
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.96543891
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94711315
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94291849
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94258350
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91471516
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91113358
102KDM2B_26808549_Chip-Seq_K562_Human0.91051187
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91007184
104TP53_16413492_ChIP-PET_HCT116_Human0.90561202
105* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90416608
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90178005
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.88221602
108STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88210205
109KDM2B_26808549_Chip-Seq_REH_Human0.86196990
110VDR_22108803_ChIP-Seq_LS180_Human0.86138500
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85360163
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.85286977
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.85101911
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84978603
115OCT4_19829295_ChIP-Seq_ESCs_Human0.84634497
116CBP_20019798_ChIP-Seq_JUKART_Human0.83788036
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83788036
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83722916
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82597193
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80208199
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79874249
122BCAT_22108803_ChIP-Seq_LS180_Human0.79510325
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79163691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.46003845
2MP0003880_abnormal_central_pattern4.94602310
3MP0004270_analgesia4.33188388
4* MP0003635_abnormal_synaptic_transmissio4.29805658
5* MP0009745_abnormal_behavioral_response3.41925756
6MP0002063_abnormal_learning/memory/cond3.40838218
7MP0002064_seizures3.06696322
8MP0001968_abnormal_touch/_nociception2.95750455
9* MP0002572_abnormal_emotion/affect_behav2.84569063
10MP0005423_abnormal_somatic_nervous2.77704259
11MP0002734_abnormal_mechanical_nocicepti2.74073320
12MP0003787_abnormal_imprinting2.65242503
13MP0009046_muscle_twitch2.56653716
14MP0001486_abnormal_startle_reflex2.46980168
15MP0002272_abnormal_nervous_system2.39157276
16MP0002735_abnormal_chemical_nociception2.28983380
17MP0000778_abnormal_nervous_system2.24492194
18MP0001440_abnormal_grooming_behavior2.19726223
19MP0002736_abnormal_nociception_after2.19360232
20MP0005646_abnormal_pituitary_gland2.16039749
21MP0001501_abnormal_sleep_pattern2.02625651
22MP0003879_abnormal_hair_cell2.00396305
23MP0002067_abnormal_sensory_capabilities1.89949118
24MP0003329_amyloid_beta_deposits1.87021807
25MP0003123_paternal_imprinting1.86086724
26MP0002733_abnormal_thermal_nociception1.85517003
27MP0002184_abnormal_innervation1.81615070
28MP0001970_abnormal_pain_threshold1.78778982
29MP0005386_behavior/neurological_phenoty1.78409502
30MP0004924_abnormal_behavior1.78409502
31MP0002822_catalepsy1.74249445
32MP0008569_lethality_at_weaning1.68779159
33MP0002557_abnormal_social/conspecific_i1.67902920
34MP0009780_abnormal_chondrocyte_physiolo1.64961466
35MP0002638_abnormal_pupillary_reflex1.62978483
36MP0004811_abnormal_neuron_physiology1.57883759
37* MP0001905_abnormal_dopamine_level1.52579340
38MP0001529_abnormal_vocalization1.52028602
39MP0003122_maternal_imprinting1.49187995
40MP0001502_abnormal_circadian_rhythm1.44148351
41MP0002882_abnormal_neuron_morphology1.43903130
42MP0006276_abnormal_autonomic_nervous1.37877915
43MP0000955_abnormal_spinal_cord1.35890449
44MP0008877_abnormal_DNA_methylation1.35878888
45* MP0002066_abnormal_motor_capabilities/c1.33906493
46MP0001984_abnormal_olfaction1.31160266
47MP0004142_abnormal_muscle_tone1.30692972
48MP0004858_abnormal_nervous_system1.29416889
49MP0002102_abnormal_ear_morphology1.29336521
50MP0002152_abnormal_brain_morphology1.18390166
51MP0003633_abnormal_nervous_system1.09244538
52MP0003631_nervous_system_phenotype1.06568032
53MP0003119_abnormal_digestive_system1.05485265
54MP0004145_abnormal_muscle_electrophysio1.04740454
55MP0003646_muscle_fatigue1.03869873
56MP0004133_heterotaxia0.99981757
57MP0003121_genomic_imprinting0.99587945
58MP0004885_abnormal_endolymph0.98805567
59MP0000631_abnormal_neuroendocrine_gland0.97786321
60MP0001963_abnormal_hearing_physiology0.96394154
61MP0000751_myopathy0.95626760
62MP0003075_altered_response_to0.94242162
63MP0002909_abnormal_adrenal_gland0.93313706
64MP0002751_abnormal_autonomic_nervous0.91249165
65MP0001188_hyperpigmentation0.90968573
66MP0005645_abnormal_hypothalamus_physiol0.90521235
67MP0005670_abnormal_white_adipose0.90004084
68MP0006292_abnormal_olfactory_placode0.89889299
69MP0003632_abnormal_nervous_system0.88910917
70MP0002069_abnormal_eating/drinking_beha0.87597552
71MP0002876_abnormal_thyroid_physiology0.84102830
72MP0010386_abnormal_urinary_bladder0.83644691
73MP0005171_absent_coat_pigmentation0.83416631
74MP0005394_taste/olfaction_phenotype0.82802814
75MP0005499_abnormal_olfactory_system0.82802814
76MP0002752_abnormal_somatic_nervous0.80667685
77MP0001348_abnormal_lacrimal_gland0.80593834
78MP0003861_abnormal_nervous_system0.80341822
79MP0005377_hearing/vestibular/ear_phenot0.79804612
80MP0003878_abnormal_ear_physiology0.79804612
81MP0008995_early_reproductive_senescence0.79127593
82MP0005409_darkened_coat_color0.78187809
83MP0008874_decreased_physiological_sensi0.77478611
84MP0001485_abnormal_pinna_reflex0.76363330
85MP0008789_abnormal_olfactory_epithelium0.75132722
86MP0000604_amyloidosis0.74373838
87MP0004742_abnormal_vestibular_system0.74266588
88MP0002229_neurodegeneration0.74230761
89MP0005551_abnormal_eye_electrophysiolog0.74044749
90MP0005253_abnormal_eye_physiology0.71838242
91MP0008872_abnormal_physiological_respon0.70657410
92MP0004215_abnormal_myocardial_fiber0.69941054
93MP0004085_abnormal_heartbeat0.68717565
94MP0001986_abnormal_taste_sensitivity0.68715497
95MP0008961_abnormal_basal_metabolism0.67921277
96MP0000049_abnormal_middle_ear0.67769964
97MP0004484_altered_response_of0.67437087
98MP0001765_abnormal_ion_homeostasis0.65785020
99MP0003137_abnormal_impulse_conducting0.65695831
100MP0001177_atelectasis0.64967416
101MP0004510_myositis0.64453217
102MP0001943_abnormal_respiration0.63596679
103MP0002234_abnormal_pharynx_morphology0.62854966
104MP0006072_abnormal_retinal_apoptosis0.59928017
105MP0000026_abnormal_inner_ear0.59528991
106MP0002081_perinatal_lethality0.59243481
107MP0003938_abnormal_ear_development0.59050251
108MP0000569_abnormal_digit_pigmentation0.58666003
109MP0003890_abnormal_embryonic-extraembry0.58579847
110MP0001664_abnormal_digestion0.58013415
111MP0010768_mortality/aging0.57402396
112MP0005187_abnormal_penis_morphology0.55734870
113MP0002653_abnormal_ependyma_morphology0.55527494
114MP0010770_preweaning_lethality0.54391574
115MP0002082_postnatal_lethality0.54391574
116MP0010769_abnormal_survival0.54221716
117MP0002837_dystrophic_cardiac_calcinosis0.54217704
118MP0000920_abnormal_myelination0.53376760
119MP0005535_abnormal_body_temperature0.52862780
120MP0003698_abnormal_male_reproductive0.52288845

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78501947
2Myokymia (HP:0002411)6.11969580
3Epileptic encephalopathy (HP:0200134)5.92338430
4Focal seizures (HP:0007359)5.90731045
5Visual hallucinations (HP:0002367)5.03863963
6Febrile seizures (HP:0002373)4.53171090
7Atonic seizures (HP:0010819)4.26516001
8Progressive cerebellar ataxia (HP:0002073)4.23551660
9Broad-based gait (HP:0002136)4.05324190
10Decreased circulating renin level (HP:0003351)4.01541647
11Generalized tonic-clonic seizures (HP:0002069)3.91307006
12Amblyopia (HP:0000646)3.70646751
13Abnormality of the lower motor neuron (HP:0002366)3.56822135
14Retinal dysplasia (HP:0007973)3.49864453
15Absence seizures (HP:0002121)3.49410276
16Limb dystonia (HP:0002451)3.41213599
17Gaze-evoked nystagmus (HP:0000640)3.39154759
18Dialeptic seizures (HP:0011146)3.37389511
19Increased circulating renin level (HP:0000848)3.27406692
20Mutism (HP:0002300)3.17917560
21Poor eye contact (HP:0000817)3.12990588
22Dysmetria (HP:0001310)3.12178774
23Ankle clonus (HP:0011448)3.10051523
24Hyperventilation (HP:0002883)3.09867100
25Supranuclear gaze palsy (HP:0000605)3.09068639
26Epileptiform EEG discharges (HP:0011182)3.06968716
27Impaired vibration sensation in the lower limbs (HP:0002166)3.06241256
28Impaired smooth pursuit (HP:0007772)3.03077673
29Abnormal eating behavior (HP:0100738)2.97646629
30Drooling (HP:0002307)2.90701481
31Excessive salivation (HP:0003781)2.90701481
32Hyperkalemia (HP:0002153)2.89636614
33Absent speech (HP:0001344)2.88719272
34Action tremor (HP:0002345)2.87719662
35Dysdiadochokinesis (HP:0002075)2.77744044
36EEG with generalized epileptiform discharges (HP:0011198)2.74020964
37Genetic anticipation (HP:0003743)2.71236316
38Urinary bladder sphincter dysfunction (HP:0002839)2.67086810
39Abnormality of binocular vision (HP:0011514)2.64809176
40Diplopia (HP:0000651)2.64809176
41Fetal akinesia sequence (HP:0001989)2.63410934
42Abnormality of ocular smooth pursuit (HP:0000617)2.60674983
43Hyperactive renin-angiotensin system (HP:0000841)2.60670134
44Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.60104236
45Hypsarrhythmia (HP:0002521)2.59585179
46Inability to walk (HP:0002540)2.55776606
47Polyphagia (HP:0002591)2.55173910
48Abnormal social behavior (HP:0012433)2.52608681
49Impaired social interactions (HP:0000735)2.52608681
50Depression (HP:0000716)2.52320696
51Postural instability (HP:0002172)2.50846592
52Truncal ataxia (HP:0002078)2.50469375
53Hepatoblastoma (HP:0002884)2.45031321
54Narrow nasal bridge (HP:0000446)2.43953511
55Oligodactyly (hands) (HP:0001180)2.40155518
56Papilledema (HP:0001085)2.38732920
57Hemiparesis (HP:0001269)2.38598939
58Progressive inability to walk (HP:0002505)2.36845821
59Obstructive sleep apnea (HP:0002870)2.36315951
60Stereotypic behavior (HP:0000733)2.35501503
61Spastic gait (HP:0002064)2.33917076
62Neurofibrillary tangles (HP:0002185)2.31840785
63Cerebral inclusion bodies (HP:0100314)2.29861146
64Torticollis (HP:0000473)2.27879048
65Hemiplegia (HP:0002301)2.26828524
66Incomplete penetrance (HP:0003829)2.25419386
67Urinary urgency (HP:0000012)2.22890164
68Protruding tongue (HP:0010808)2.22381895
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.19921363
70Scanning speech (HP:0002168)2.18306512
71Impaired vibratory sensation (HP:0002495)2.17188116
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.13293283
73Hypoplasia of the brainstem (HP:0002365)2.13293283
74Status epilepticus (HP:0002133)2.13158650
75Long foot (HP:0001833)2.11409109
76Generalized myoclonic seizures (HP:0002123)2.10740501
77Abnormality of the labia minora (HP:0012880)2.10290442
78Annular pancreas (HP:0001734)2.09837145
79Focal dystonia (HP:0004373)2.09060906
80Anxiety (HP:0000739)2.06305444
81Inappropriate behavior (HP:0000719)2.03677775
82Bradykinesia (HP:0002067)2.03671422
83Ventricular fibrillation (HP:0001663)2.03550369
84Abnormality of the corticospinal tract (HP:0002492)2.03303386
85Lissencephaly (HP:0001339)2.01590550
86Delusions (HP:0000746)1.99176472
87Lower limb muscle weakness (HP:0007340)1.96607339
88Amyotrophic lateral sclerosis (HP:0007354)1.94780845
89Termporal pattern (HP:0011008)1.94167168
90Insidious onset (HP:0003587)1.94167168
91Sleep apnea (HP:0010535)1.93943087
92Insomnia (HP:0100785)1.92415843
93Generalized hypopigmentation of hair (HP:0011358)1.91628865
94Elfin facies (HP:0004428)1.91009741
95Intention tremor (HP:0002080)1.90562602
96Anomalous pulmonary venous return (HP:0010772)1.89781242
97Abnormality of renin-angiotensin system (HP:0000847)1.89597260
98Abnormality of the intervertebral disk (HP:0005108)1.89279359
99Dysmetric saccades (HP:0000641)1.86631817
100Lower limb amyotrophy (HP:0007210)1.86101339
101Abnormality of salivation (HP:0100755)1.85344159
102Nephronophthisis (HP:0000090)1.85284400
103Pointed chin (HP:0000307)1.84887985
104Hypoplasia of the corpus callosum (HP:0002079)1.84852401
105Fair hair (HP:0002286)1.84474326
106Gait imbalance (HP:0002141)1.84222018
107Intellectual disability, severe (HP:0010864)1.81818885
108Esotropia (HP:0000565)1.80699410
109Craniofacial dystonia (HP:0012179)1.79224397
110Widely spaced teeth (HP:0000687)1.78861342
111Exotropia (HP:0000577)1.78539045
112Morphological abnormality of the pyramidal tract (HP:0002062)1.77621244
113Failure to thrive in infancy (HP:0001531)1.77426095
114Blue irides (HP:0000635)1.77097907
115Tubulointerstitial nephritis (HP:0001970)1.76528733
116Optic nerve hypoplasia (HP:0000609)1.76113397
117Arterial tortuosity (HP:0005116)1.75623024
118Bony spicule pigmentary retinopathy (HP:0007737)1.75477856
119Pachygyria (HP:0001302)1.74454004
120Bundle branch block (HP:0011710)1.74410153
121Nonprogressive disorder (HP:0003680)1.74319463
122Enlarged penis (HP:0000040)1.73862140
123Gait ataxia (HP:0002066)1.72935974
124Specific learning disability (HP:0001328)1.72847687
125Spastic tetraparesis (HP:0001285)1.71136344
126Decreased central vision (HP:0007663)1.70268489
127Abnormality of the diencephalon (HP:0010662)1.68557534
128Cutaneous finger syndactyly (HP:0010554)1.65679185
129Abnormality of macular pigmentation (HP:0008002)1.65268412
130Abnormality of the aortic arch (HP:0012303)1.65160058
131Abnormality of the pubic bones (HP:0003172)1.64041502
132Oligodactyly (HP:0012165)1.62927105
133Peripheral hypomyelination (HP:0007182)1.62625029
134Pendular nystagmus (HP:0012043)1.61071208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK36.82059359
2INSRR5.19823821
3EPHA43.78469343
4MAP3K93.67561363
5MAP3K42.92756281
6MARK12.89367286
7PRPF4B2.84179750
8DAPK22.69386109
9MAP2K72.61290359
10PAK62.35373902
11FRK2.24415673
12NTRK22.24367721
13KSR22.22123759
14KSR12.15215966
15MAPK132.05138822
16MINK11.94168253
17TNIK1.92282957
18MAP2K41.91401395
19LATS21.87772103
20CASK1.85476065
21MAP3K121.69144190
22DAPK11.57738650
23CAMK1D1.57313768
24MAP4K21.55573161
25MAP3K61.49541161
26CDK191.48769140
27PRKD31.45485430
28CDK51.41993238
29PLK21.37690422
30TYRO31.33451220
31ICK1.32011077
32FES1.30120041
33WNK31.25587917
34TAOK11.20592826
35CAMKK11.10691615
36TAOK21.09984525
37RAF11.09506686
38BCR1.07469963
39STK381.06509983
40RIPK41.01844886
41GRK51.00827181
42BMPR1B0.97597564
43PRKCG0.96195755
44MUSK0.95915488
45CCNB10.93221413
46MAP3K130.92711815
47CDK180.91633435
48CAMK2A0.90749003
49CDK150.90399164
50NTRK10.89128466
51ARAF0.87399407
52CSNK1G20.86409765
53CAMK10.85730250
54MAP3K20.83601948
55NME10.83278889
56TRIM280.81676614
57STK110.81043334
58SGK4940.80449580
59SGK2230.80449580
60CDK11A0.80258339
61PKN10.78088050
62UHMK10.77796497
63DYRK20.76619111
64SIK30.75022405
65SIK20.74926680
66CDK140.74822360
67PAK30.73947326
68OXSR10.73632118
69CAMK2B0.72591153
70PTK2B0.72188719
71RET0.69684241
72MARK20.68141632
73DYRK1B0.65368003
74FGFR20.64393128
75DYRK1A0.64121960
76FGR0.63688347
77ADRBK20.63325802
78FER0.62859956
79SGK10.62783555
80SGK20.62208274
81CSNK1A1L0.61968857
82CDC42BPA0.60113058
83PHKG20.57513555
84PHKG10.57513555
85CAMKK20.56473367
86MATK0.56421458
87CSNK1G30.55651590
88TNK20.55580689
89MAP3K10.53995001
90BRD40.53877336
91ERBB20.51014222
92PNCK0.49980704
93PRKCH0.49735977
94BRAF0.49523443
95PRKAA10.46009557
96DYRK30.44158555
97BMPR20.43908397
98PDK10.43798530
99EPHB20.43472943
100ADRBK10.41600957
101MAPK120.41428008
102MAPK80.40919265
103PRKCE0.38985609
104BRSK10.38799716
105RPS6KA30.38452213
106SGK30.38356473
107RPS6KA20.37797656
108CSNK1G10.37733440
109GSK3B0.37061414
110PASK0.36870562
111MAPK150.36536081
112ALK0.36247484
113CAMK1G0.35940916
114PRKCZ0.35619558
115MAP3K110.34664752
116MAP3K70.34361796
117AKT30.34245823
118CAMK40.34194449
119CSNK1A10.33432737
120MAP2K10.33372470
121PRKACA0.33183030
122NEK60.32669968
123PDPK10.32365941
124MAPK100.32266982
125PLK40.31645314
126PRKD20.31618241
127CSNK1D0.31199838
128CAMK2G0.30333524
129PRKG10.30096454
130ERBB40.30007829
131DDR20.29789217
132FYN0.28591125
133DMPK0.27952974
134PINK10.27869062
135MOS0.25984406
136DAPK30.24931263

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00131160
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12131480
3Circadian entrainment_Homo sapiens_hsa047133.11299834
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91944971
5Long-term potentiation_Homo sapiens_hsa047202.83927254
6* Glutamatergic synapse_Homo sapiens_hsa047242.82382857
7GABAergic synapse_Homo sapiens_hsa047272.62882853
8Amphetamine addiction_Homo sapiens_hsa050312.46334016
9Olfactory transduction_Homo sapiens_hsa047402.40956097
10Morphine addiction_Homo sapiens_hsa050322.37406518
11Dopaminergic synapse_Homo sapiens_hsa047282.14357236
12Insulin secretion_Homo sapiens_hsa049112.09176059
13Aldosterone synthesis and secretion_Homo sapiens_hsa049252.09020173
14Salivary secretion_Homo sapiens_hsa049702.08403100
15Cholinergic synapse_Homo sapiens_hsa047252.05234974
16Long-term depression_Homo sapiens_hsa047301.96034725
17Oxytocin signaling pathway_Homo sapiens_hsa049211.90487007
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90356368
19GnRH signaling pathway_Homo sapiens_hsa049121.89444295
20Gastric acid secretion_Homo sapiens_hsa049711.76626807
21Taste transduction_Homo sapiens_hsa047421.73264070
22Serotonergic synapse_Homo sapiens_hsa047261.69969017
23Calcium signaling pathway_Homo sapiens_hsa040201.67930356
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57140986
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56822766
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53435667
27Renin secretion_Homo sapiens_hsa049241.51400531
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.47031906
29Type II diabetes mellitus_Homo sapiens_hsa049301.42339287
30cAMP signaling pathway_Homo sapiens_hsa040241.35183508
31Estrogen signaling pathway_Homo sapiens_hsa049151.31836042
32Axon guidance_Homo sapiens_hsa043601.30716024
33Gap junction_Homo sapiens_hsa045401.29804160
34Collecting duct acid secretion_Homo sapiens_hsa049661.24518122
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23782649
36Circadian rhythm_Homo sapiens_hsa047101.22822832
37* Cocaine addiction_Homo sapiens_hsa050301.21192409
38Oocyte meiosis_Homo sapiens_hsa041141.20722178
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18239789
40ErbB signaling pathway_Homo sapiens_hsa040121.16959421
41Glioma_Homo sapiens_hsa052141.15604052
42Melanogenesis_Homo sapiens_hsa049161.07361375
43* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04203934
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02689192
45* Phospholipase D signaling pathway_Homo sapiens_hsa040721.01704923
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.00947317
47Choline metabolism in cancer_Homo sapiens_hsa052310.96096387
48Dorso-ventral axis formation_Homo sapiens_hsa043200.86881299
49MAPK signaling pathway_Homo sapiens_hsa040100.84645257
50VEGF signaling pathway_Homo sapiens_hsa043700.81790877
51Butanoate metabolism_Homo sapiens_hsa006500.81368061
52Ovarian steroidogenesis_Homo sapiens_hsa049130.79756152
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79303614
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76865925
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75502225
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73212793
57Ras signaling pathway_Homo sapiens_hsa040140.71544883
58Cardiac muscle contraction_Homo sapiens_hsa042600.70928625
59Dilated cardiomyopathy_Homo sapiens_hsa054140.68382425
60Pancreatic secretion_Homo sapiens_hsa049720.68144083
61Thyroid hormone synthesis_Homo sapiens_hsa049180.67694115
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67481436
63Vibrio cholerae infection_Homo sapiens_hsa051100.66296158
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65396133
65Notch signaling pathway_Homo sapiens_hsa043300.64314441
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64312665
67Basal cell carcinoma_Homo sapiens_hsa052170.63871427
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61876770
69Hedgehog signaling pathway_Homo sapiens_hsa043400.60900195
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58887266
71Wnt signaling pathway_Homo sapiens_hsa043100.57354240
72Hippo signaling pathway_Homo sapiens_hsa043900.57261884
73Phototransduction_Homo sapiens_hsa047440.56097547
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54784185
75Glucagon signaling pathway_Homo sapiens_hsa049220.54734040
76Inositol phosphate metabolism_Homo sapiens_hsa005620.53894900
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52411785
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.52404583
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52170119
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51170600
81Ether lipid metabolism_Homo sapiens_hsa005650.50729959
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.49556454
83Rap1 signaling pathway_Homo sapiens_hsa040150.48921462
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45748019
85Endometrial cancer_Homo sapiens_hsa052130.45670348
86Prion diseases_Homo sapiens_hsa050200.45326009
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45164941
88Renal cell carcinoma_Homo sapiens_hsa052110.42340380
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42034372
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41661254
91Colorectal cancer_Homo sapiens_hsa052100.41499799
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40260571
93AMPK signaling pathway_Homo sapiens_hsa041520.37522266
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36554567
95Prolactin signaling pathway_Homo sapiens_hsa049170.36069661
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.35184096
97Tight junction_Homo sapiens_hsa045300.34921817
98Regulation of autophagy_Homo sapiens_hsa041400.33399714
99Bile secretion_Homo sapiens_hsa049760.32828404
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.32082432
101African trypanosomiasis_Homo sapiens_hsa051430.31908297
102Chemokine signaling pathway_Homo sapiens_hsa040620.31841209
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30895107
104Insulin signaling pathway_Homo sapiens_hsa049100.30815283
105Non-small cell lung cancer_Homo sapiens_hsa052230.30381542
106Endocytosis_Homo sapiens_hsa041440.28479668
107Glycerolipid metabolism_Homo sapiens_hsa005610.28471841
108mTOR signaling pathway_Homo sapiens_hsa041500.28398007
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28325805
110Alcoholism_Homo sapiens_hsa050340.27463964
111Fatty acid biosynthesis_Homo sapiens_hsa000610.26103565
112Nitrogen metabolism_Homo sapiens_hsa009100.25185838
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23313498
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23176508
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21816407

Most similar genes based on co-expression Upload to Enrichr

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