GRM6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.82949593
2relaxation of smooth muscle (GO:0044557)8.48799430
3* detection of light stimulus involved in visual perception (GO:0050908)8.32656863
4* detection of light stimulus involved in sensory perception (GO:0050962)8.32656863
5cellular potassium ion homeostasis (GO:0030007)8.20645486
6positive regulation of synapse maturation (GO:0090129)7.77165174
7response to pheromone (GO:0019236)7.16356890
8potassium ion homeostasis (GO:0055075)7.14214970
9sodium ion export (GO:0071436)7.09283532
10urinary tract smooth muscle contraction (GO:0014848)6.48492665
11regulation of synapse maturation (GO:0090128)6.14786731
12gamma-aminobutyric acid signaling pathway (GO:0007214)5.63736588
13positive regulation of dendritic spine morphogenesis (GO:0061003)5.63431975
14synaptic vesicle exocytosis (GO:0016079)5.52540297
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.40703719
16synaptic vesicle endocytosis (GO:0048488)5.27455920
17neurotransmitter-gated ion channel clustering (GO:0072578)5.26651580
18striatum development (GO:0021756)4.84395220
19innervation (GO:0060384)4.77280907
20behavioral response to nicotine (GO:0035095)4.72577920
21cellular sodium ion homeostasis (GO:0006883)4.62186943
22cell communication by electrical coupling (GO:0010644)4.58352008
23mating behavior (GO:0007617)4.56564065
24potassium ion export (GO:0071435)4.55618285
25retinal cone cell development (GO:0046549)4.54218100
26eye photoreceptor cell development (GO:0042462)4.46013385
27photoreceptor cell development (GO:0042461)4.41335634
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.35534861
29substrate-independent telencephalic tangential migration (GO:0021826)4.35534861
30L-fucose catabolic process (GO:0042355)4.31957962
31fucose catabolic process (GO:0019317)4.31957962
32L-fucose metabolic process (GO:0042354)4.31957962
33regulation of synaptic vesicle exocytosis (GO:2000300)4.24111038
34protein localization to synapse (GO:0035418)4.18304544
35* G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.10403290
36platelet dense granule organization (GO:0060155)4.01177605
37positive regulation of gastrulation (GO:2000543)4.00937891
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.00429768
39response to host (GO:0075136)4.00429768
40response to host defenses (GO:0052200)4.00429768
41iron coordination entity transport (GO:1901678)4.00358371
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98892660
43peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.95619621
44cellular ketone body metabolic process (GO:0046950)3.91531266
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.90204274
46response to host immune response (GO:0052572)3.90204274
47nitric oxide mediated signal transduction (GO:0007263)3.89746575
48positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.88756764
49regulation of bile acid biosynthetic process (GO:0070857)3.88604517
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88332825
51calcium ion import (GO:0070509)3.83366370
52regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.82549396
53regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.82549396
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.81601310
55axoneme assembly (GO:0035082)3.80541881
56synaptic vesicle maturation (GO:0016188)3.78861691
57axon cargo transport (GO:0008088)3.73834682
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73757642
59atrial cardiac muscle cell action potential (GO:0086014)3.73123301
60establishment of synaptic vesicle localization (GO:0097480)3.71083877
61synaptic vesicle transport (GO:0048489)3.71083877
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68907926
63phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.68666320
64glycolytic process (GO:0006096)3.67759321
65negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.67520445
66layer formation in cerebral cortex (GO:0021819)3.64547826
67indolalkylamine metabolic process (GO:0006586)3.64184784
68indole-containing compound catabolic process (GO:0042436)3.63212720
69indolalkylamine catabolic process (GO:0046218)3.63212720
70tryptophan catabolic process (GO:0006569)3.63212720
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62674651
72rhodopsin mediated signaling pathway (GO:0016056)3.59988722
73peristalsis (GO:0030432)3.57740983
74prepulse inhibition (GO:0060134)3.57574696
75sensory perception of light stimulus (GO:0050953)3.57263348
76regulation of cilium movement (GO:0003352)3.57026535
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.56008302
78visual perception (GO:0007601)3.54476036
79water-soluble vitamin biosynthetic process (GO:0042364)3.51759571
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50638079
81ketone body metabolic process (GO:1902224)3.50627869
82anterograde axon cargo transport (GO:0008089)3.49213659
83positive regulation of TOR signaling (GO:0032008)3.48561760
84regulation of secondary heart field cardioblast proliferation (GO:0003266)3.46848173
85regulation of cardioblast proliferation (GO:0003264)3.46848173
86pyrimidine dimer repair (GO:0006290)3.46157341
87regulation of transforming growth factor beta2 production (GO:0032909)3.45993386
88kynurenine metabolic process (GO:0070189)3.45888319
89DNA deamination (GO:0045006)3.45559485
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44133890
91positive regulation of cell cycle checkpoint (GO:1901978)3.41905613
92synapse assembly (GO:0007416)3.38725158
93endocardial cushion morphogenesis (GO:0003203)3.37948312
94positive regulation of CREB transcription factor activity (GO:0032793)3.37022993
95nonmotile primary cilium assembly (GO:0035058)3.35250543
96membrane depolarization during action potential (GO:0086010)3.34895798
97membrane hyperpolarization (GO:0060081)3.33435595
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32910011
99photoreceptor cell maintenance (GO:0045494)3.30863755
100cGMP biosynthetic process (GO:0006182)3.26784441
101protein polyglutamylation (GO:0018095)3.26499108
102epithelial cilium movement (GO:0003351)3.26368915
103long term synaptic depression (GO:0060292)3.24921816
104protein-chromophore linkage (GO:0018298)3.24402180
105dentate gyrus development (GO:0021542)3.22665828
106regulation of synaptic vesicle transport (GO:1902803)3.20876514
107regulation of voltage-gated calcium channel activity (GO:1901385)3.19906486
108RNA localization (GO:0006403)3.16819504
109protein-cofactor linkage (GO:0018065)3.15048388
110heart field specification (GO:0003128)3.10620633
111secondary heart field specification (GO:0003139)3.10620633
112behavioral response to ethanol (GO:0048149)3.08237343
113relaxation of muscle (GO:0090075)3.07131246
114amine catabolic process (GO:0009310)3.05976892
115cellular biogenic amine catabolic process (GO:0042402)3.05976892
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05886821
117regulation of rhodopsin mediated signaling pathway (GO:0022400)3.03665311
118gamma-aminobutyric acid transport (GO:0015812)3.02967758
119positive regulation of cGMP biosynthetic process (GO:0030828)3.02675051
120response to histamine (GO:0034776)3.02634166
121positive regulation of dendritic spine development (GO:0060999)3.00914015
122negative regulation of mast cell activation (GO:0033004)3.00078510
123lactate metabolic process (GO:0006089)2.98963183
124tryptophan metabolic process (GO:0006568)2.98933066
125detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.98216245
126detection of temperature stimulus involved in sensory perception (GO:0050961)2.98216245
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.97787684
128regulation of synapse structural plasticity (GO:0051823)2.96722027
129protein complex biogenesis (GO:0070271)2.96482376
130neuronal action potential propagation (GO:0019227)2.94367571
131sulfation (GO:0051923)2.92154045
132C4-dicarboxylate transport (GO:0015740)2.91805368
133regulation of glucokinase activity (GO:0033131)2.87422721
134regulation of hexokinase activity (GO:1903299)2.87422721
135mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86735966
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.86735966
137NADH dehydrogenase complex assembly (GO:0010257)2.86735966
138cilium organization (GO:0044782)2.83027196
139prenylation (GO:0097354)2.81317577
140protein prenylation (GO:0018342)2.81317577
141preassembly of GPI anchor in ER membrane (GO:0016254)2.79504039
142cilium morphogenesis (GO:0060271)2.78357964
143cornea development in camera-type eye (GO:0061303)2.77204589
144protein localization to cilium (GO:0061512)2.77104003
145regulation of neurotransmitter uptake (GO:0051580)2.76376948
146mannosylation (GO:0097502)2.75392236
147pyrimidine nucleobase catabolic process (GO:0006208)2.75017334
148cilium assembly (GO:0042384)2.74026739
149neural tube formation (GO:0001841)2.73299055
150S-adenosylmethionine metabolic process (GO:0046500)2.72533101
151ubiquinone biosynthetic process (GO:0006744)2.72194305
152indole-containing compound metabolic process (GO:0042430)2.70828638
153negative regulation of telomere maintenance (GO:0032205)2.70826037
154piRNA metabolic process (GO:0034587)2.69866249
155respiratory chain complex IV assembly (GO:0008535)2.68233737
156neuronal action potential (GO:0019228)2.67869401
157tachykinin receptor signaling pathway (GO:0007217)2.67579883
158somite development (GO:0061053)2.67259506
159mitochondrial respiratory chain complex assembly (GO:0033108)2.65442389
160dopamine transport (GO:0015872)2.63109691
161cilium movement (GO:0003341)2.61648668
162intraciliary transport (GO:0042073)2.61258999
163glycerophospholipid catabolic process (GO:0046475)2.59437070
164ubiquinone metabolic process (GO:0006743)2.59271367
165transmission of nerve impulse (GO:0019226)2.57449734
166L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55082877
167reflex (GO:0060004)2.54816914
168regulation of action potential (GO:0098900)2.54178856
169anterograde synaptic vesicle transport (GO:0048490)2.51833735
170nucleobase catabolic process (GO:0046113)2.50825300
171auditory receptor cell stereocilium organization (GO:0060088)2.49835326
172primary amino compound metabolic process (GO:1901160)2.47856876
173multicellular organism reproduction (GO:0032504)2.47629686
174cytochrome complex assembly (GO:0017004)2.45506922
175inner ear receptor stereocilium organization (GO:0060122)2.44191594
176regulation of microtubule-based movement (GO:0060632)2.44079780
177synaptic transmission, cholinergic (GO:0007271)2.44066976
178protein K11-linked deubiquitination (GO:0035871)2.41706332
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.41052757
180replication fork processing (GO:0031297)2.39662259
181adaptation of signaling pathway (GO:0023058)2.39548339
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37428650
183tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37428650
184centriole replication (GO:0007099)2.36301253
185recombinational repair (GO:0000725)2.36118078
186reciprocal meiotic recombination (GO:0007131)2.35882579
187reciprocal DNA recombination (GO:0035825)2.35882579
188negative regulation of cytosolic calcium ion concentration (GO:0051481)10.5500255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.64463294
2GBX2_23144817_ChIP-Seq_PC3_Human4.23370199
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.76108118
4ZNF274_21170338_ChIP-Seq_K562_Hela3.74521326
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.28187051
6EZH2_22144423_ChIP-Seq_EOC_Human2.77520658
7REST_21632747_ChIP-Seq_MESCs_Mouse2.75135233
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64813105
9DROSHA_22980978_ChIP-Seq_HELA_Human2.63822637
10P53_22127205_ChIP-Seq_FIBROBLAST_Human2.50365899
11AR_21572438_ChIP-Seq_LNCaP_Human2.45525045
12* EZH2_27294783_Chip-Seq_ESCs_Mouse2.42223447
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37236049
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34779231
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29428415
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.28486914
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26724304
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25432924
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23656618
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23089069
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.22507874
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15271981
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.07321287
24EWS_26573619_Chip-Seq_HEK293_Human2.06559662
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04787571
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04462796
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02551929
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01799021
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93314414
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90825082
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90493524
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.88752116
33TAF15_26573619_Chip-Seq_HEK293_Human1.88365364
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86237722
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86110451
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86110451
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85998571
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83805653
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81210435
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81106892
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81082109
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80170827
43FUS_26573619_Chip-Seq_HEK293_Human1.79846157
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.77065527
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.73404470
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71961221
47SMAD4_21799915_ChIP-Seq_A2780_Human1.65362330
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63533023
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61787605
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.60710087
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57919261
52BCAT_22108803_ChIP-Seq_LS180_Human1.57073203
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55317866
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52981940
55TP53_22573176_ChIP-Seq_HFKS_Human1.49306557
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45077646
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.44276416
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43522182
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43310699
60IRF1_19129219_ChIP-ChIP_H3396_Human1.42576649
61TCF4_22108803_ChIP-Seq_LS180_Human1.42305391
62AR_25329375_ChIP-Seq_VCAP_Human1.42186067
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41570795
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40957181
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40543169
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39868916
67RNF2_27304074_Chip-Seq_NSC_Mouse1.38965037
68IGF1R_20145208_ChIP-Seq_DFB_Human1.38199428
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35673394
70P300_19829295_ChIP-Seq_ESCs_Human1.35626446
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35497327
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.35081918
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33900915
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33089513
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33089513
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.32931591
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.32772770
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32492799
79SOX2_19829295_ChIP-Seq_ESCs_Human1.31862148
80NANOG_19829295_ChIP-Seq_ESCs_Human1.31862148
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31663300
82AR_19668381_ChIP-Seq_PC3_Human1.31442203
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.30461949
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29413192
85RUNX2_22187159_ChIP-Seq_PCA_Human1.28872024
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.28738176
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.26783960
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25589408
89MYC_18940864_ChIP-ChIP_HL60_Human1.25439663
90STAT3_23295773_ChIP-Seq_U87_Human1.25235509
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24994714
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.24693013
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24370991
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.24370991
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22905765
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22257324
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.21694123
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21453263
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21440085
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21168159
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20864874
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20445331
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19855695
104VDR_22108803_ChIP-Seq_LS180_Human1.18813605
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.18676129
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18245853
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.18132152
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.16820939
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16500960
110NCOR_22424771_ChIP-Seq_293T_Human1.16490392
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16336359
112HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16148867
113P53_22387025_ChIP-Seq_ESCs_Mouse1.15178136
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14620708
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14475680
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14352221
117* TCF4_23295773_ChIP-Seq_U87_Human1.13368055
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12998235
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.12319249
120CBP_20019798_ChIP-Seq_JUKART_Human1.11641238
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11641238
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.10300059
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.09991788
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.09952639
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09111656
126AR_20517297_ChIP-Seq_VCAP_Human1.08553200
127CDX2_22108803_ChIP-Seq_LS180_Human1.05656219
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05017729
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04973435
130TRIM28_21343339_ChIP-Seq_HEK293_Human1.04334844
131ELK1_19687146_ChIP-ChIP_HELA_Human1.03682199
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03637047
133EST1_17652178_ChIP-ChIP_JURKAT_Human1.03074786
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03071896
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.02952234
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02101482
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01912887
138WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01538887
139CBP_21632823_ChIP-Seq_H3396_Human1.01471207
140HOXB7_26014856_ChIP-Seq_BT474_Human1.00122025
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.99879524
142CTCF_27219007_Chip-Seq_Bcells_Human0.99851231
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99459378
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97645015
145AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97184035
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97175151
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96513957
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96033038
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95969974
150ER_23166858_ChIP-Seq_MCF-7_Human0.95641112
151MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95157654
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95048020
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94982549
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94801267
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93387506
156VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90491462
157TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89714967
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89568488
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89118991
160SOX9_26525672_Chip-Seq_HEART_Mouse0.88309724
161SMAD_19615063_ChIP-ChIP_OVARY_Human0.88013232
162WDR5_24793694_ChIP-Seq_LNCAP_Human0.87542758
163* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87119682
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87068738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog6.52522604
2MP0002090_abnormal_vision5.52902242
3MP0006072_abnormal_retinal_apoptosis5.14272611
4MP0001984_abnormal_olfaction4.57813433
5MP0004233_abnormal_muscle_weight3.47108313
6MP0005253_abnormal_eye_physiology3.43075565
7MP0010386_abnormal_urinary_bladder3.31577554
8MP0006292_abnormal_olfactory_placode3.24452039
9MP0001502_abnormal_circadian_rhythm3.16055628
10MP0008877_abnormal_DNA_methylation3.02659946
11MP0001346_abnormal_lacrimal_gland2.84122886
12MP0005195_abnormal_posterior_eye2.70007918
13MP0005248_abnormal_Harderian_gland2.65582641
14MP0003195_calcinosis2.63410957
15MP0004782_abnormal_surfactant_physiolog2.46392338
16MP0008775_abnormal_heart_ventricle2.38796278
17MP0004036_abnormal_muscle_relaxation2.35320478
18MP0002638_abnormal_pupillary_reflex2.31607915
19MP0002102_abnormal_ear_morphology2.31134821
20MP0004084_abnormal_cardiac_muscle2.26002123
21MP0003950_abnormal_plasma_membrane2.18813063
22MP0002837_dystrophic_cardiac_calcinosis2.16578186
23MP0002876_abnormal_thyroid_physiology2.09908194
24MP0004147_increased_porphyrin_level2.09748376
25MP0003011_delayed_dark_adaptation2.04354184
26MP0003880_abnormal_central_pattern1.94574617
27MP0000372_irregular_coat_pigmentation1.91539979
28MP0000569_abnormal_digit_pigmentation1.91000923
29MP0003787_abnormal_imprinting1.90192169
30MP0010030_abnormal_orbit_morphology1.89728183
31MP0005645_abnormal_hypothalamus_physiol1.88141726
32MP0003136_yellow_coat_color1.83091235
33MP0005499_abnormal_olfactory_system1.79673461
34MP0005394_taste/olfaction_phenotype1.79673461
35MP0002229_neurodegeneration1.76987376
36MP0009046_muscle_twitch1.75851951
37MP0001986_abnormal_taste_sensitivity1.74549680
38MP0008789_abnormal_olfactory_epithelium1.72421804
39MP0002234_abnormal_pharynx_morphology1.72300196
40MP0002184_abnormal_innervation1.70263590
41MP0002332_abnormal_exercise_endurance1.67108525
42MP0005084_abnormal_gallbladder_morpholo1.63914829
43MP0002938_white_spotting1.63847163
44MP0003646_muscle_fatigue1.59178685
45MP0002272_abnormal_nervous_system1.58568882
46MP0001188_hyperpigmentation1.56249420
47MP0005391_vision/eye_phenotype1.55892689
48MP0001324_abnormal_eye_pigmentation1.55790655
49MP0006276_abnormal_autonomic_nervous1.55091633
50MP0010368_abnormal_lymphatic_system1.54899993
51MP0002752_abnormal_somatic_nervous1.54847518
52MP0002909_abnormal_adrenal_gland1.53204401
53MP0002067_abnormal_sensory_capabilities1.53097863
54MP0008875_abnormal_xenobiotic_pharmacok1.52557241
55MP0005670_abnormal_white_adipose1.51862773
56MP0004215_abnormal_myocardial_fiber1.51401939
57MP0002735_abnormal_chemical_nociception1.49055654
58MP0003868_abnormal_feces_composition1.47570211
59MP0000427_abnormal_hair_cycle1.45917737
60MP0003879_abnormal_hair_cell1.45903584
61MP0001486_abnormal_startle_reflex1.44774768
62MP0005595_abnormal_vascular_smooth1.44538649
63MP0005423_abnormal_somatic_nervous1.43868086
64* MP0003635_abnormal_synaptic_transmissio1.39598197
65MP0002064_seizures1.38996075
66MP0002734_abnormal_mechanical_nocicepti1.38134608
67MP0001485_abnormal_pinna_reflex1.35944474
68MP0005174_abnormal_tail_pigmentation1.35357981
69MP0002733_abnormal_thermal_nociception1.32376401
70MP0001970_abnormal_pain_threshold1.32340992
71MP0002822_catalepsy1.32114121
72MP0001529_abnormal_vocalization1.29130119
73MP0004133_heterotaxia1.27707315
74MP0000631_abnormal_neuroendocrine_gland1.27226436
75MP0005167_abnormal_blood-brain_barrier1.25768638
76MP0005410_abnormal_fertilization1.22463146
77MP0002063_abnormal_learning/memory/cond1.22328061
78MP0009697_abnormal_copulation1.20491644
79MP0005220_abnormal_exocrine_pancreas1.16549065
80MP0008569_lethality_at_weaning1.15888170
81MP0002882_abnormal_neuron_morphology1.15654716
82MP0004145_abnormal_muscle_electrophysio1.15269468
83MP0001968_abnormal_touch/_nociception1.09262406
84MP0005389_reproductive_system_phenotype1.07859538
85MP0005379_endocrine/exocrine_gland_phen1.07856791
86MP0003718_maternal_effect1.07087374
87MP0002928_abnormal_bile_duct1.05987451
88MP0009745_abnormal_behavioral_response1.05962166
89MP0003890_abnormal_embryonic-extraembry1.04467158
90MP0001919_abnormal_reproductive_system1.02997549
91MP0003121_genomic_imprinting1.02772142
92MP0004859_abnormal_synaptic_plasticity1.02197046
93MP0002095_abnormal_skin_pigmentation1.01292457
94MP0002163_abnormal_gland_morphology1.01199136
95MP0002138_abnormal_hepatobiliary_system1.00655902
96MP0001905_abnormal_dopamine_level0.99651034
97MP0002160_abnormal_reproductive_system0.97731666
98MP0008058_abnormal_DNA_repair0.94153723
99MP0002254_reproductive_system_inflammat0.94128415
100MP0001501_abnormal_sleep_pattern0.91734355
101MP0003698_abnormal_male_reproductive0.91673590
102MP0001764_abnormal_homeostasis0.90990378
103MP0000026_abnormal_inner_ear0.89218117
104MP0003122_maternal_imprinting0.88781636
105MP0000778_abnormal_nervous_system0.88099126
106MP0003878_abnormal_ear_physiology0.87706764
107MP0005377_hearing/vestibular/ear_phenot0.87706764
108MP0002572_abnormal_emotion/affect_behav0.86346058
109MP0005620_abnormal_muscle_contractility0.86316774
110MP0000751_myopathy0.85415764
111MP0005332_abnormal_amino_acid0.84505235
112MP0008260_abnormal_autophagy0.83745017
113MP0000955_abnormal_spinal_cord0.82355630
114MP0008004_abnormal_stomach_pH0.81988253
115MP0002277_abnormal_respiratory_mucosa0.81747781
116MP0005187_abnormal_penis_morphology0.81659105
117MP0004085_abnormal_heartbeat0.78486685
118MP0000647_abnormal_sebaceous_gland0.78478064
119MP0000566_synostosis0.78273313
120MP0005075_abnormal_melanosome_morpholog0.76530799
121MP0001929_abnormal_gametogenesis0.76199598
122MP0006035_abnormal_mitochondrial_morpho0.75331870
123MP0004742_abnormal_vestibular_system0.74687626
124MP0002736_abnormal_nociception_after0.72376199
125MP0003634_abnormal_glial_cell0.72022553
126MP0004811_abnormal_neuron_physiology0.70898001
127MP0002751_abnormal_autonomic_nervous0.67799645
128MP0002697_abnormal_eye_size0.65302009
129MP0000230_abnormal_systemic_arterial0.64756866
130MP0005386_behavior/neurological_phenoty0.64528359
131MP0004924_abnormal_behavior0.64528359
132MP0000534_abnormal_ureter_morphology0.60574464
133MP0004043_abnormal_pH_regulation0.59137720
134MP0005646_abnormal_pituitary_gland0.58973085
135MP0002557_abnormal_social/conspecific_i0.58584884
136MP0002269_muscular_atrophy0.57620332
137MP0003137_abnormal_impulse_conducting0.55425434
138MP0003172_abnormal_lysosome_physiology0.54772690
139MP0003633_abnormal_nervous_system0.54393015
140MP0001177_atelectasis0.52354838
141MP0002066_abnormal_motor_capabilities/c0.51822028
142MP0002653_abnormal_ependyma_morphology0.50230502
143MP0008872_abnormal_physiological_respon0.49852262
144MP0002089_abnormal_postnatal_growth/wei0.48830393
145MP0003221_abnormal_cardiomyocyte_apopto0.47926783
146MP0004885_abnormal_endolymph0.46396679
147MP0005623_abnormal_meninges_morphology0.45572486
148MP0001963_abnormal_hearing_physiology0.45239666
149MP0002152_abnormal_brain_morphology0.44916461
150MP0002069_abnormal_eating/drinking_beha0.44681456
151MP0004142_abnormal_muscle_tone0.44306350

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.17141339
2Severe visual impairment (HP:0001141)8.11397137
3Abnormality of macular pigmentation (HP:0008002)7.12747371
4Abnormal rod and cone electroretinograms (HP:0008323)6.51617332
5Decreased central vision (HP:0007663)5.97152729
6Scotoma (HP:0000575)5.42240400
7Septo-optic dysplasia (HP:0100842)5.41122145
8Increased corneal curvature (HP:0100692)5.15254871
9Keratoconus (HP:0000563)5.15254871
10Bony spicule pigmentary retinopathy (HP:0007737)4.64161363
11Abnormal gallbladder physiology (HP:0012438)4.57198439
12Cholecystitis (HP:0001082)4.57198439
13Aplasia/Hypoplasia of the fovea (HP:0008060)4.54529674
14Hypoplasia of the fovea (HP:0007750)4.54529674
15Epileptic encephalopathy (HP:0200134)4.48033820
16Pancreatic cysts (HP:0001737)4.46391418
17Pancreatic fibrosis (HP:0100732)4.41033961
18Abnormality of midbrain morphology (HP:0002418)4.26330537
19Molar tooth sign on MRI (HP:0002419)4.26330537
20Absence seizures (HP:0002121)3.96964846
21Albinism (HP:0001022)3.93174701
22Nephronophthisis (HP:0000090)3.78970926
23Febrile seizures (HP:0002373)3.68478591
24Abnormality of the fovea (HP:0000493)3.62445148
25Abnormality of the renal cortex (HP:0011035)3.56065792
26Severe Myopia (HP:0011003)3.46979883
27Abnormality of the renal medulla (HP:0100957)3.31170413
28Hyperventilation (HP:0002883)3.23881943
29Chronic hepatic failure (HP:0100626)3.15368405
30Hemiparesis (HP:0001269)3.12760013
31Aplasia/Hypoplasia of the macula (HP:0008059)3.10548690
32Aplasia/Hypoplasia affecting the retina (HP:0008061)3.09995129
33Dialeptic seizures (HP:0011146)3.06443209
34Prolonged QT interval (HP:0001657)2.96260851
35Attenuation of retinal blood vessels (HP:0007843)2.90133275
36Pendular nystagmus (HP:0012043)2.83765350
37Renal cortical cysts (HP:0000803)2.81547732
38Type II lissencephaly (HP:0007260)2.77985616
39Abnormal drinking behavior (HP:0030082)2.76470398
40Polydipsia (HP:0001959)2.76470398
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75514604
42Cystic liver disease (HP:0006706)2.72943499
43Abolished electroretinogram (ERG) (HP:0000550)2.71305058
44EEG with generalized epileptiform discharges (HP:0011198)2.67118656
45Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.64675930
46Absent septum pellucidum (HP:0001331)2.64357202
47Optic nerve hypoplasia (HP:0000609)2.63125424
48Progressive cerebellar ataxia (HP:0002073)2.60681256
49Tubular atrophy (HP:0000092)2.56624475
50Abnormal pupillary function (HP:0007686)2.56185113
51Epileptiform EEG discharges (HP:0011182)2.55632580
52Abdominal situs inversus (HP:0003363)2.55038420
53Abnormality of abdominal situs (HP:0011620)2.55038420
54Sclerocornea (HP:0000647)2.46754756
55Photophobia (HP:0000613)2.38781445
56Methylmalonic acidemia (HP:0002912)2.38071908
57Acute necrotizing encephalopathy (HP:0006965)2.33907057
58Abnormality of the septum pellucidum (HP:0007375)2.30536344
59Methylmalonic aciduria (HP:0012120)2.27770082
60Polyuria (HP:0000103)2.26985724
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.26465080
62Congenital hepatic fibrosis (HP:0002612)2.25452437
63Inability to walk (HP:0002540)2.25258841
64Dysdiadochokinesis (HP:0002075)2.23880802
65Type II diabetes mellitus (HP:0005978)2.21904291
66Progressive inability to walk (HP:0002505)2.21795467
67Generalized tonic-clonic seizures (HP:0002069)2.21607481
68Genital tract atresia (HP:0001827)2.16880261
69Acute encephalopathy (HP:0006846)2.15576450
70Abnormal biliary tract physiology (HP:0012439)2.14013678
71Bile duct proliferation (HP:0001408)2.14013678
72Broad-based gait (HP:0002136)2.13531001
73Anencephaly (HP:0002323)2.13336131
74Pigmentary retinal degeneration (HP:0001146)2.12300816
75Mutism (HP:0002300)2.11954623
76Lissencephaly (HP:0001339)2.11686354
77Furrowed tongue (HP:0000221)2.10085111
78Male pseudohermaphroditism (HP:0000037)2.09889358
79Progressive macrocephaly (HP:0004481)2.09456201
80Generalized hypopigmentation (HP:0007513)2.08580682
81Postaxial foot polydactyly (HP:0001830)2.08282292
82Chorioretinal atrophy (HP:0000533)2.07568544
83Focal motor seizures (HP:0011153)2.07199573
84Vaginal atresia (HP:0000148)2.06832342
85Astigmatism (HP:0000483)2.06047024
86Hypothermia (HP:0002045)2.05862388
87Large for gestational age (HP:0001520)2.05785644
88Long toe (HP:0010511)2.05008397
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04418344
90Absent speech (HP:0001344)2.04374166
91Abnormality of alanine metabolism (HP:0010916)2.04162880
92Hyperalaninemia (HP:0003348)2.04162880
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04162880
94Retinitis pigmentosa (HP:0000510)2.04132589
95Congenital sensorineural hearing impairment (HP:0008527)2.03870210
96Mitochondrial inheritance (HP:0001427)2.03536341
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.00467381
98Increased CSF lactate (HP:0002490)2.00003570
99Congenital stationary night blindness (HP:0007642)18.1475057
100Absent/shortened dynein arms (HP:0200106)1.99938849
101Dynein arm defect of respiratory motile cilia (HP:0012255)1.99938849
102Occipital encephalocele (HP:0002085)1.99857389
103Gait imbalance (HP:0002141)1.99246774
104Intestinal atresia (HP:0011100)1.96650105
105Constricted visual fields (HP:0001133)1.95522285
106Dyschromatopsia (HP:0007641)1.94063964
107Ketosis (HP:0001946)1.93895690
108Stomach cancer (HP:0012126)1.93795622
109Abnormal mitochondria in muscle tissue (HP:0008316)1.93304310
110Abnormality of the labia minora (HP:0012880)1.93004975
111Neoplasm of the heart (HP:0100544)1.92802847
112Cone-rod dystrophy (HP:0000548)1.90973015
113Cerebellar dysplasia (HP:0007033)1.90944752
114Ketoacidosis (HP:0001993)1.90944635
115Exercise-induced myalgia (HP:0003738)1.90321127
116Hypomagnesemia (HP:0002917)1.90089412
117Congenital primary aphakia (HP:0007707)1.89589652
118Abnormal respiratory motile cilium morphology (HP:0005938)1.88652879
119Abnormal respiratory epithelium morphology (HP:0012253)1.88652879
120Postaxial hand polydactyly (HP:0001162)1.87803354
121Choroideremia (HP:0001139)1.86430054
122Growth hormone deficiency (HP:0000824)1.84767024
123Hyperglycinuria (HP:0003108)1.84503939
124Congenital, generalized hypertrichosis (HP:0004540)1.84441742
125Dysmetric saccades (HP:0000641)1.83680190
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.81676000
127Abnormal EKG (HP:0003115)1.80376737
128Abnormal urine output (HP:0012590)1.79014031
129Severe muscular hypotonia (HP:0006829)1.78990307
130Thyroid-stimulating hormone excess (HP:0002925)1.78619284
131Tachypnea (HP:0002789)1.78391968
132Short tibia (HP:0005736)1.78118748
133Chorioretinal coloboma (HP:0000567)1.78058930
134Unsteady gait (HP:0002317)1.77305658
1353-Methylglutaconic aciduria (HP:0003535)1.77020989
136Focal seizures (HP:0007359)1.76995493
137Depression (HP:0000716)1.74010972
138Exercise-induced muscle cramps (HP:0003710)1.73028157
139Fatigue (HP:0012378)1.72996879
140Truncal ataxia (HP:0002078)1.71571210
141Medial flaring of the eyebrow (HP:0010747)1.70239352
142Atrial fibrillation (HP:0005110)1.69475146
143Nephrogenic diabetes insipidus (HP:0009806)1.69418617
144Ventricular fibrillation (HP:0001663)1.68523490
145Gastrointestinal dysmotility (HP:0002579)1.62056026
146Poor coordination (HP:0002370)1.58816709
147Volvulus (HP:0002580)1.57300963
148Widely spaced teeth (HP:0000687)1.53347673
149Maternal diabetes (HP:0009800)1.52781752
150Primary atrial arrhythmia (HP:0001692)1.49774800
151Genetic anticipation (HP:0003743)1.49350044
152Hypsarrhythmia (HP:0002521)1.46774302
153Supraventricular tachycardia (HP:0004755)1.43917779
154Myoglobinuria (HP:0002913)1.42665275
155Syncope (HP:0001279)1.42480775
156Optic disc pallor (HP:0000543)1.42395519
157Visual hallucinations (HP:0002367)1.41525282
158Cholelithiasis (HP:0001081)1.41172251
159Gaze-evoked nystagmus (HP:0000640)1.40051167
160Retinal dysplasia (HP:0007973)1.39859105
161True hermaphroditism (HP:0010459)1.39669135
162Limb ataxia (HP:0002070)1.39011469
163Supranuclear gaze palsy (HP:0000605)1.39006354
164Partial agenesis of the corpus callosum (HP:0001338)1.37973292
165Supraventricular arrhythmia (HP:0005115)1.37633653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07086006
2PBK5.04826227
3PRPF4B4.11349821
4NEK13.73508411
5TAOK23.62605653
6PAK63.51706697
7MAP4K23.13099340
8NME13.05553334
9ADRBK22.98066110
10INSRR2.83055503
11EPHA32.67595239
12RIPK12.62082118
13STK38L2.60077780
14BMPR1B2.52977767
15MAP3K132.48503284
16NUAK12.39255529
17PHKG12.36282708
18PHKG22.36282708
19WNK42.30561732
20MINK12.25001632
21STK382.23363705
22TIE12.22027113
23ZAK2.20502486
24MAP3K42.19745633
25DYRK1A2.10413578
26TLK12.06308473
27ACVR1B1.99994085
28MAP3K71.88331602
29MARK11.87497846
30STK391.68904270
31TNK21.66345263
32FES1.59686946
33MAP3K91.56418657
34MKNK21.47443786
35TAOK31.45672522
36PINK11.45585373
37BCKDK1.39972726
38CAMK2D1.39263773
39OXSR11.38695727
40CAMK1D1.37520165
41TRIM281.36615864
42EPHA41.33615246
43PRKAA11.32675994
44TXK1.25118626
45DYRK21.23260683
46CDK31.23140683
47PLK21.16370405
48BCR1.13135178
49ADRBK11.06228375
50MST41.04897819
51CLK11.04208186
52CAMK11.02692456
53PTK2B1.00680168
54CAMK1G1.00557104
55SGK2230.95724578
56SGK4940.95724578
57PNCK0.94195177
58FER0.93581530
59CSNK1G20.90647684
60TEC0.90495169
61ROCK20.88464825
62MAP3K60.88214521
63CSNK1G10.87371543
64MAP2K70.85214632
65CSNK1G30.84183159
66BRD40.81720538
67BRSK20.81595480
68MUSK0.80535650
69VRK10.80436341
70CDK140.80143184
71IRAK10.77037311
72CAMKK10.77031117
73CDK80.75929941
74PAK30.74634053
75PRKG20.74341697
76EIF2AK30.73584060
77WNK30.73437599
78PKN10.73258198
79GRK10.72609902
80CDK90.72527515
81PLK40.72481714
82TNIK0.71854901
83STK30.71071069
84DYRK1B0.71067226
85TGFBR10.70555853
86DAPK20.69914637
87PRKG10.69470260
88STK160.67732088
89MAPKAPK30.65832392
90PRKCE0.64230893
91DYRK30.64087547
92PLK30.63327320
93PRKD20.62851871
94CAMK2A0.62001855
95MKNK10.61100793
96CSNK1A1L0.60848284
97CDK50.60672369
98RPS6KB20.59175673
99NEK20.58548087
100CDK150.56975228
101PRKCA0.56459231
102PRKCQ0.56285385
103ERBB30.56275293
104PRKCZ0.54180162
105PIK3CA0.54087784
106IKBKB0.53328266
107CDK180.51746040
108IRAK20.51684795
109FGFR20.50896930
110MAPK100.50835254
111GRK70.50724614
112PRKCB0.50437739
113ERBB20.50034509
114NTRK30.49569791
115PRKCI0.49028467
116CDK11A0.49025795
117PRKCG0.48960444
118RPS6KA30.48955080
119PRKACA0.48064625
120HIPK20.46899468
121CSNK1A10.46536744
122FGFR10.46250613
123RPS6KA50.46010323
124CHEK20.45949907
125PRKD30.45053918
126AKT30.44650655
127GSK3B0.43692839
128BMX0.43686197
129MARK20.42970967
130CAMK40.42750152
131ROCK10.42684436
132CSNK1D0.41582876
133CASK0.40296309
134SIK20.39911860
135MAPK80.36606946
136MAP2K60.35521753
137FLT30.35315320
138MAPK90.35104653
139ITK0.34959988
140AKT20.34559842
141NLK0.34114554
142PRKACB0.33577977
143MAPK10.33348970
144PKN20.32302818
145SGK20.31786905
146SRPK10.31676672
147OBSCN0.30646261
148MAP2K40.30371174
149PDK20.30337285
150CDC42BPA0.30013540
151NTRK20.30001989
152MAPK140.29493211
153EIF2AK10.29462820
154MAPKAPK50.28859640
155MAPK130.28660337
156CAMKK20.28634670
157PRKACG0.27150834
158PRKAA20.26617434
159FYN0.24425870
160CDK10.24217884

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.48430280
2GABAergic synapse_Homo sapiens_hsa047274.29254414
3Synaptic vesicle cycle_Homo sapiens_hsa047214.07841521
4Morphine addiction_Homo sapiens_hsa050323.65882696
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.38559984
6Circadian rhythm_Homo sapiens_hsa047103.22301148
7Butanoate metabolism_Homo sapiens_hsa006502.65970337
8Circadian entrainment_Homo sapiens_hsa047132.59311720
9Phototransduction_Homo sapiens_hsa047442.58829736
10Fructose and mannose metabolism_Homo sapiens_hsa000512.53459941
11Olfactory transduction_Homo sapiens_hsa047402.40844618
12Renin secretion_Homo sapiens_hsa049242.31083724
13Insulin secretion_Homo sapiens_hsa049112.29376602
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28822788
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26379082
16Nitrogen metabolism_Homo sapiens_hsa009102.18729919
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.18198633
18Salivary secretion_Homo sapiens_hsa049702.04269955
19Oxidative phosphorylation_Homo sapiens_hsa001902.01726644
20Selenocompound metabolism_Homo sapiens_hsa004502.01716666
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.99990762
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.94756753
23Basal transcription factors_Homo sapiens_hsa030221.89201483
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85787466
25Biosynthesis of amino acids_Homo sapiens_hsa012301.82883638
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80939329
27Ether lipid metabolism_Homo sapiens_hsa005651.79567027
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77803072
29Protein export_Homo sapiens_hsa030601.75655789
30Homologous recombination_Homo sapiens_hsa034401.70216165
31Cholinergic synapse_Homo sapiens_hsa047251.69938613
32Tryptophan metabolism_Homo sapiens_hsa003801.69205687
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68868694
34Oxytocin signaling pathway_Homo sapiens_hsa049211.63069057
35Propanoate metabolism_Homo sapiens_hsa006401.62925285
36Cardiac muscle contraction_Homo sapiens_hsa042601.62186983
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61322349
38Caffeine metabolism_Homo sapiens_hsa002321.53508795
39Serotonergic synapse_Homo sapiens_hsa047261.52248862
40Parkinsons disease_Homo sapiens_hsa050121.50636424
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50175178
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50118491
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.47627306
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.46694075
45Fanconi anemia pathway_Homo sapiens_hsa034601.44430953
46Dilated cardiomyopathy_Homo sapiens_hsa054141.43342647
47Taste transduction_Homo sapiens_hsa047421.43317236
48Collecting duct acid secretion_Homo sapiens_hsa049661.41229172
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34635100
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33847245
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31171699
52Mineral absorption_Homo sapiens_hsa049781.30212436
53Pentose phosphate pathway_Homo sapiens_hsa000301.28423316
54Dopaminergic synapse_Homo sapiens_hsa047281.28198023
55Peroxisome_Homo sapiens_hsa041461.27936554
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27330855
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27011559
58Chemical carcinogenesis_Homo sapiens_hsa052041.22951948
59* Glutamatergic synapse_Homo sapiens_hsa047241.22858034
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22428930
61RNA polymerase_Homo sapiens_hsa030201.17893021
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.17466385
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14335285
64Vascular smooth muscle contraction_Homo sapiens_hsa042701.12680538
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12348050
66Calcium signaling pathway_Homo sapiens_hsa040201.11072626
67Retinol metabolism_Homo sapiens_hsa008301.04686177
68Gap junction_Homo sapiens_hsa045401.03226066
69Arachidonic acid metabolism_Homo sapiens_hsa005901.02595144
70Type II diabetes mellitus_Homo sapiens_hsa049301.02234074
71Galactose metabolism_Homo sapiens_hsa000520.99622254
72Huntingtons disease_Homo sapiens_hsa050160.99053937
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89515341
74Alzheimers disease_Homo sapiens_hsa050100.89133401
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88705344
76Steroid biosynthesis_Homo sapiens_hsa001000.86970502
77Carbon metabolism_Homo sapiens_hsa012000.86447521
78One carbon pool by folate_Homo sapiens_hsa006700.83921806
79Glycerolipid metabolism_Homo sapiens_hsa005610.83914805
80Sulfur metabolism_Homo sapiens_hsa009200.80469011
81beta-Alanine metabolism_Homo sapiens_hsa004100.79342206
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78758564
83Non-homologous end-joining_Homo sapiens_hsa034500.78259284
84cAMP signaling pathway_Homo sapiens_hsa040240.76140308
85* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75695648
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74775590
87Inositol phosphate metabolism_Homo sapiens_hsa005620.73107506
88Fat digestion and absorption_Homo sapiens_hsa049750.72805186
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72629633
90HIF-1 signaling pathway_Homo sapiens_hsa040660.72294786
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70564944
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69529555
93mTOR signaling pathway_Homo sapiens_hsa041500.69468784
94Pancreatic secretion_Homo sapiens_hsa049720.68671585
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.67554110
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67004095
97Metabolic pathways_Homo sapiens_hsa011000.64631975
98Long-term depression_Homo sapiens_hsa047300.62913109
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61675377
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59787786
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56016349
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.55200586
103Alcoholism_Homo sapiens_hsa050340.54139817
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51484248
105Arginine and proline metabolism_Homo sapiens_hsa003300.50749755
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49487564
107GnRH signaling pathway_Homo sapiens_hsa049120.49317665
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49161535
109Primary immunodeficiency_Homo sapiens_hsa053400.46990094
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46383399
111Fatty acid degradation_Homo sapiens_hsa000710.45118267
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44906483
113Histidine metabolism_Homo sapiens_hsa003400.44137873
114Hedgehog signaling pathway_Homo sapiens_hsa043400.44064092
115Bile secretion_Homo sapiens_hsa049760.43678524
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43422977
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43051971
118Glucagon signaling pathway_Homo sapiens_hsa049220.43028434
119Vibrio cholerae infection_Homo sapiens_hsa051100.41258403
120Gastric acid secretion_Homo sapiens_hsa049710.39753981
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39030497
122Cocaine addiction_Homo sapiens_hsa050300.38633752
123ABC transporters_Homo sapiens_hsa020100.38172535
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38147024
125Fatty acid metabolism_Homo sapiens_hsa012120.37244764
126Amphetamine addiction_Homo sapiens_hsa050310.37130188
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35054300
128Purine metabolism_Homo sapiens_hsa002300.34764168
129Pyruvate metabolism_Homo sapiens_hsa006200.33561610
130MAPK signaling pathway_Homo sapiens_hsa040100.33011162
131AMPK signaling pathway_Homo sapiens_hsa041520.32699547
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31821262
133Nucleotide excision repair_Homo sapiens_hsa034200.28495382
134Fatty acid elongation_Homo sapiens_hsa000620.28006235
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27928112
136Proteasome_Homo sapiens_hsa030500.27855936
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27579354
138Lysine degradation_Homo sapiens_hsa003100.27376421
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26978534
140Choline metabolism in cancer_Homo sapiens_hsa052310.25678781
141Linoleic acid metabolism_Homo sapiens_hsa005910.23723929
142Rheumatoid arthritis_Homo sapiens_hsa053230.22092857
143Thyroid hormone synthesis_Homo sapiens_hsa049180.21568909
144Arginine biosynthesis_Homo sapiens_hsa002200.21292054
145Ovarian steroidogenesis_Homo sapiens_hsa049130.18788448
146Renal cell carcinoma_Homo sapiens_hsa052110.17632639
147Colorectal cancer_Homo sapiens_hsa052100.17255273
148Protein digestion and absorption_Homo sapiens_hsa049740.17222664
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16379532
150Ras signaling pathway_Homo sapiens_hsa040140.15228092
151Lysosome_Homo sapiens_hsa041420.13263126
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12720596
153Sphingolipid metabolism_Homo sapiens_hsa006000.12368159
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12315522
155Starch and sucrose metabolism_Homo sapiens_hsa005000.12154049
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.12049805
157RNA degradation_Homo sapiens_hsa030180.11750392
158Regulation of autophagy_Homo sapiens_hsa041400.11104882
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08895303
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07519654
161SNARE interactions in vesicular transport_Homo sapiens_hsa041300.05666778

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