GRM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84669302
2synaptic vesicle exocytosis (GO:0016079)5.55742717
3vocalization behavior (GO:0071625)5.30286961
4glutamate secretion (GO:0014047)5.18697419
5regulation of synaptic vesicle exocytosis (GO:2000300)5.14825899
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.07775936
7neuronal action potential propagation (GO:0019227)5.07491962
8neuron cell-cell adhesion (GO:0007158)5.05363943
9protein polyglutamylation (GO:0018095)4.88487218
10regulation of feeding behavior (GO:0060259)4.87049990
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.86581385
12protein localization to synapse (GO:0035418)4.84453707
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82913163
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75266926
15positive regulation of amino acid transport (GO:0051957)4.69792606
16synaptic vesicle maturation (GO:0016188)4.63653921
17pyrimidine nucleobase catabolic process (GO:0006208)4.59052507
18regulation of synaptic vesicle transport (GO:1902803)4.54790123
19locomotory exploration behavior (GO:0035641)4.52967503
20regulation of glutamate receptor signaling pathway (GO:1900449)4.51657581
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.39209178
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.35422409
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34229619
24neurotransmitter secretion (GO:0007269)4.29885193
25neuron recognition (GO:0008038)4.22712614
26neurotransmitter-gated ion channel clustering (GO:0072578)4.17003859
27* glutamate receptor signaling pathway (GO:0007215)4.13003537
28neuron-neuron synaptic transmission (GO:0007270)4.09173684
29presynaptic membrane assembly (GO:0097105)4.04295594
30synaptic transmission, glutamatergic (GO:0035249)4.01629187
31negative regulation of transcription regulatory region DNA binding (GO:2000678)3.95112086
32exploration behavior (GO:0035640)3.90011263
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.89211435
34response to histamine (GO:0034776)3.84562491
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78076727
36proline transport (GO:0015824)3.75437431
37axonal fasciculation (GO:0007413)3.74588857
38layer formation in cerebral cortex (GO:0021819)3.70469706
39nucleobase catabolic process (GO:0046113)3.70456622
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69242467
41response to pheromone (GO:0019236)3.68080131
42negative regulation of dendrite morphogenesis (GO:0050774)3.67470959
43limb bud formation (GO:0060174)3.66507031
44regulation of postsynaptic membrane potential (GO:0060078)3.66049772
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.65046552
46gamma-aminobutyric acid transport (GO:0015812)3.63599973
47regulation of neuronal synaptic plasticity (GO:0048168)3.61776014
48neurotransmitter transport (GO:0006836)3.60750418
49spinal cord association neuron differentiation (GO:0021527)3.60671240
50presynaptic membrane organization (GO:0097090)3.60255299
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59529302
52sequestering of actin monomers (GO:0042989)3.58158680
53nonmotile primary cilium assembly (GO:0035058)3.56154811
54regulation of microtubule-based movement (GO:0060632)3.55093795
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53038459
56postsynaptic membrane organization (GO:0001941)3.49077838
57negative regulation of amino acid transport (GO:0051956)3.47444921
58regulation of neurotransmitter secretion (GO:0046928)3.45656450
59positive regulation of membrane potential (GO:0045838)3.43880487
60negative regulation of dendrite development (GO:2000171)3.43652367
61transmission of nerve impulse (GO:0019226)3.41899629
62long-term synaptic potentiation (GO:0060291)3.41532236
63behavioral fear response (GO:0001662)3.38044662
64behavioral defense response (GO:0002209)3.38044662
65regulation of synapse structural plasticity (GO:0051823)3.37204155
66cerebellar Purkinje cell differentiation (GO:0021702)3.37107260
67cell migration in hindbrain (GO:0021535)3.34254815
68cerebellar granule cell differentiation (GO:0021707)3.33111007
69* G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31489813
70* regulation of synaptic transmission, glutamatergic (GO:0051966)3.30641600
71positive regulation of meiosis (GO:0045836)3.29849757
72innervation (GO:0060384)3.29805765
73regulation of translation, ncRNA-mediated (GO:0045974)3.26617274
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.26617274
75negative regulation of translation, ncRNA-mediated (GO:0040033)3.26617274
76opioid receptor signaling pathway (GO:0038003)3.25670947
77activation of protein kinase A activity (GO:0034199)3.24228953
78membrane hyperpolarization (GO:0060081)3.23695235
79regulation of neurotransmitter levels (GO:0001505)3.23381676
80fear response (GO:0042596)3.22681940
81regulation of synaptic plasticity (GO:0048167)3.21967690
82microtubule depolymerization (GO:0007019)3.21308911
83positive regulation of neurotransmitter secretion (GO:0001956)3.21074491
84regulation of glutamate secretion (GO:0014048)3.18021195
85neuromuscular process controlling posture (GO:0050884)3.16716215
86membrane depolarization during action potential (GO:0086010)3.15035480
87sperm motility (GO:0030317)3.12900652
88cGMP biosynthetic process (GO:0006182)3.12663007
89membrane depolarization (GO:0051899)3.12602372
90establishment of protein localization to Golgi (GO:0072600)3.12298834
91regulation of vesicle fusion (GO:0031338)3.10699007
92long-term memory (GO:0007616)3.10465843
93dendritic spine morphogenesis (GO:0060997)3.09191758
94imidazole-containing compound metabolic process (GO:0052803)3.08957052
95regulation of cilium movement (GO:0003352)3.08889031
96regulation of appetite (GO:0032098)3.07440028
97protein targeting to Golgi (GO:0000042)3.07172256
98positive regulation of meiotic cell cycle (GO:0051446)3.06452945
99regulation of neurotransmitter transport (GO:0051588)3.05730698
100synaptic vesicle endocytosis (GO:0048488)3.05336822
101startle response (GO:0001964)3.04954128
102regulation of phospholipid biosynthetic process (GO:0071071)3.04868601
103positive regulation of synapse maturation (GO:0090129)3.03974872
104serotonin receptor signaling pathway (GO:0007210)3.03790427
105positive regulation of neurotransmitter transport (GO:0051590)3.01823521
106synapse assembly (GO:0007416)3.01251828
107synaptic transmission (GO:0007268)2.98961818
108cochlea development (GO:0090102)2.98262967
109behavioral response to cocaine (GO:0048148)2.98097735
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96911959
111calcium ion-dependent exocytosis (GO:0017156)2.95615244
112positive regulation of gastrulation (GO:2000543)2.94668155
113vesicle transport along microtubule (GO:0047496)2.93791254
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93010562
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92470718
116positive regulation of synapse assembly (GO:0051965)2.91774307
117regulation of cAMP-dependent protein kinase activity (GO:2000479)2.90764185
118righting reflex (GO:0060013)2.88185833
119social behavior (GO:0035176)2.85356114
120intraspecies interaction between organisms (GO:0051703)2.85356114
121positive regulation of synaptic transmission (GO:0050806)2.85085407
122dendrite morphogenesis (GO:0048813)2.83959215
123retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83524415
124organelle transport along microtubule (GO:0072384)2.82965401
125* regulation of synaptic transmission (GO:0050804)2.82550825
126epithelial cilium movement (GO:0003351)2.81923958
127energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81195049
128ATP hydrolysis coupled proton transport (GO:0015991)2.81195049
129learning (GO:0007612)2.79773750
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79726764
131cGMP metabolic process (GO:0046068)2.77968573
132neurofilament cytoskeleton organization (GO:0060052)2.76332458
133microtubule polymerization or depolymerization (GO:0031109)2.74714759
134cilium movement (GO:0003341)2.74520731
135olfactory bulb development (GO:0021772)2.74162286
136auditory behavior (GO:0031223)2.73880864
137adult walking behavior (GO:0007628)2.73771690
138positive regulation of amine transport (GO:0051954)2.71460928
139brain morphogenesis (GO:0048854)2.69331884
140male meiosis (GO:0007140)2.68349148
141somite development (GO:0061053)2.67177462
142axonemal dynein complex assembly (GO:0070286)2.67122847
143detection of light stimulus involved in sensory perception (GO:0050962)2.66784156
144detection of light stimulus involved in visual perception (GO:0050908)2.66784156
145protein localization to Golgi apparatus (GO:0034067)2.65729709
146regulation of amino acid transport (GO:0051955)2.64590566
147cilium morphogenesis (GO:0060271)2.64142233
148behavioral response to nicotine (GO:0035095)2.63772823
149dopaminergic neuron differentiation (GO:0071542)2.63431096
150piRNA metabolic process (GO:0034587)2.61695203
151intraciliary transport (GO:0042073)2.61676336
152cilium assembly (GO:0042384)2.59130980
153cilium or flagellum-dependent cell motility (GO:0001539)2.59066563
154acrosome reaction (GO:0007340)2.58869931
155axoneme assembly (GO:0035082)2.56940178
156retinal ganglion cell axon guidance (GO:0031290)2.56430602
157cilium organization (GO:0044782)2.56387686
158cell wall macromolecule metabolic process (GO:0044036)2.55947624
159nephron epithelium morphogenesis (GO:0072088)2.55579406
160nephron tubule morphogenesis (GO:0072078)2.55579406
161mechanosensory behavior (GO:0007638)2.55454116
162neuronal action potential (GO:0019228)2.53833211
163cell differentiation in spinal cord (GO:0021515)2.53308755
164spinal cord development (GO:0021510)2.52044005
165neuromuscular synaptic transmission (GO:0007274)2.48595513
166hippocampus development (GO:0021766)2.48322157
167photoreceptor cell development (GO:0042461)2.48071771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89556038
2GBX2_23144817_ChIP-Seq_PC3_Human4.11891988
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20878754
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94650895
5TAF15_26573619_Chip-Seq_HEK293_Human2.94233994
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89838491
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81741397
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74277987
9REST_21632747_ChIP-Seq_MESCs_Mouse2.48745564
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48453675
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48453675
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47474779
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.43238193
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41640607
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40659417
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38720813
17* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34013962
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.26786959
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25610563
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25566203
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22934092
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19930286
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13046881
24AR_21572438_ChIP-Seq_LNCaP_Human2.12464706
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.01891350
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99324002
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98458645
28DROSHA_22980978_ChIP-Seq_HELA_Human1.98193623
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.96353874
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.93945122
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.88977315
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.86197678
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85812886
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84233268
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81736718
36P300_19829295_ChIP-Seq_ESCs_Human1.77695607
37IGF1R_20145208_ChIP-Seq_DFB_Human1.73963830
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66023681
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65425904
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60119358
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55009711
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54953230
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53588281
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.51980569
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.50452858
46ZNF274_21170338_ChIP-Seq_K562_Hela1.50420278
47AR_25329375_ChIP-Seq_VCAP_Human1.50179962
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48870017
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.48118401
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45761021
51EWS_26573619_Chip-Seq_HEK293_Human1.43306303
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42528033
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.39505255
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39300172
55FUS_26573619_Chip-Seq_HEK293_Human1.39017044
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38723010
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36145189
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35675780
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35632943
60* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34633057
61* STAT3_23295773_ChIP-Seq_U87_Human1.33593847
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33369141
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31890482
64VDR_22108803_ChIP-Seq_LS180_Human1.27368542
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.26728610
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.26700697
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25887832
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24292742
69ER_23166858_ChIP-Seq_MCF-7_Human1.22412947
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21873571
71* TCF4_23295773_ChIP-Seq_U87_Human1.21393088
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20499808
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17552956
74* AR_19668381_ChIP-Seq_PC3_Human1.16853610
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16591859
76* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16551265
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.16091986
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15441259
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.15287284
80* RUNX2_22187159_ChIP-Seq_PCA_Human1.14856894
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11494877
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10457997
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.10374724
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10286353
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10286353
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.10223334
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.09385086
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.09304333
89BCAT_22108803_ChIP-Seq_LS180_Human1.09163070
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09061932
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06974012
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06920658
93AHR_22903824_ChIP-Seq_MCF-7_Human1.06908441
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.06179638
95JUN_21703547_ChIP-Seq_K562_Human1.06051345
96* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05294063
97KDM2B_26808549_Chip-Seq_REH_Human1.05120748
98TCF4_22108803_ChIP-Seq_LS180_Human1.03793948
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03201797
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02160936
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01749837
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01663461
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.01099614
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00256295
105SOX2_19829295_ChIP-Seq_ESCs_Human0.99788524
106NANOG_19829295_ChIP-Seq_ESCs_Human0.99788524
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99260405
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99132597
109SOX9_26525672_Chip-Seq_HEART_Mouse0.98525651
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.98248543
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98115478
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.97140035
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96781752
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95742025
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94812918
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94580359
117TP53_18474530_ChIP-ChIP_U2OS_Human0.94071543
118TP53_16413492_ChIP-PET_HCT116_Human0.93589475
119CBP_20019798_ChIP-Seq_JUKART_Human0.92258443
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92258443
121E2F1_18555785_Chip-Seq_ESCs_Mouse0.92102830
122* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91807536
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91724713
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.91418586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.22312957
2MP0004859_abnormal_synaptic_plasticity5.18377098
3MP0003635_abnormal_synaptic_transmissio3.91663126
4MP0004270_analgesia3.68879048
5MP0001968_abnormal_touch/_nociception3.47324874
6MP0000566_synostosis3.39800596
7MP0009745_abnormal_behavioral_response3.38112474
8MP0009046_muscle_twitch3.30232992
9MP0002064_seizures3.17572378
10* MP0002063_abnormal_learning/memory/cond3.12134449
11MP0002736_abnormal_nociception_after2.79911912
12* MP0002572_abnormal_emotion/affect_behav2.75180796
13MP0002734_abnormal_mechanical_nocicepti2.74976347
14MP0005423_abnormal_somatic_nervous2.70822180
15MP0002735_abnormal_chemical_nociception2.68642547
16MP0002272_abnormal_nervous_system2.62762951
17MP0001486_abnormal_startle_reflex2.49051793
18MP0000372_irregular_coat_pigmentation2.27188616
19MP0006276_abnormal_autonomic_nervous2.25784109
20MP0001440_abnormal_grooming_behavior2.21770411
21MP0002067_abnormal_sensory_capabilities2.21156159
22MP0001501_abnormal_sleep_pattern2.19437141
23MP0002733_abnormal_thermal_nociception2.11580563
24MP0002184_abnormal_innervation1.95912318
25MP0001970_abnormal_pain_threshold1.94773536
26MP0003329_amyloid_beta_deposits1.87463069
27MP0003011_delayed_dark_adaptation1.86580330
28MP0000778_abnormal_nervous_system1.84137974
29MP0004142_abnormal_muscle_tone1.81119364
30MP0003890_abnormal_embryonic-extraembry1.80580838
31MP0005551_abnormal_eye_electrophysiolog1.80112810
32MP0008995_early_reproductive_senescence1.79838383
33MP0004924_abnormal_behavior1.77758684
34MP0005386_behavior/neurological_phenoty1.77758684
35MP0003879_abnormal_hair_cell1.77480085
36MP0008569_lethality_at_weaning1.73707672
37MP0010030_abnormal_orbit_morphology1.72387925
38MP0002557_abnormal_social/conspecific_i1.70846562
39MP0003787_abnormal_imprinting1.70760996
40MP0005646_abnormal_pituitary_gland1.61952272
41MP0009780_abnormal_chondrocyte_physiolo1.58260948
42MP0001529_abnormal_vocalization1.56848172
43MP0002822_catalepsy1.55525625
44MP0004811_abnormal_neuron_physiology1.46832664
45MP0003119_abnormal_digestive_system1.45817698
46MP0005410_abnormal_fertilization1.45151301
47MP0008789_abnormal_olfactory_epithelium1.44875095
48MP0002882_abnormal_neuron_morphology1.43898234
49MP0008961_abnormal_basal_metabolism1.43599353
50MP0003122_maternal_imprinting1.41689288
51MP0002234_abnormal_pharynx_morphology1.41682062
52MP0002876_abnormal_thyroid_physiology1.41309644
53MP0001293_anophthalmia1.41087391
54* MP0002066_abnormal_motor_capabilities/c1.39576128
55MP0000955_abnormal_spinal_cord1.38136107
56MP0001984_abnormal_olfaction1.37861829
57MP0002837_dystrophic_cardiac_calcinosis1.34595724
58MP0009697_abnormal_copulation1.31646276
59MP0003937_abnormal_limbs/digits/tail_de1.30324477
60MP0001905_abnormal_dopamine_level1.27907892
61MP0005645_abnormal_hypothalamus_physiol1.27884675
62MP0000537_abnormal_urethra_morphology1.27724446
63MP0004858_abnormal_nervous_system1.26431813
64MP0000569_abnormal_digit_pigmentation1.25678017
65MP0003718_maternal_effect1.25023037
66MP0001502_abnormal_circadian_rhythm1.24181735
67MP0003183_abnormal_peptide_metabolism1.21671188
68MP0002909_abnormal_adrenal_gland1.21466428
69MP0000427_abnormal_hair_cycle1.20578767
70MP0003698_abnormal_male_reproductive1.20446184
71MP0002751_abnormal_autonomic_nervous1.17663647
72MP0002229_neurodegeneration1.17267414
73MP0000751_myopathy1.13273141
74MP0001188_hyperpigmentation1.12577954
75MP0003959_abnormal_lean_body1.09363746
76MP0002938_white_spotting1.08231347
77MP0003633_abnormal_nervous_system1.05974845
78MP0008872_abnormal_physiological_respon1.02908120
79MP0004742_abnormal_vestibular_system1.01071544
80MP0002152_abnormal_brain_morphology1.00170571
81MP0003631_nervous_system_phenotype0.99297492
82MP0002752_abnormal_somatic_nervous0.98951926
83MP0003938_abnormal_ear_development0.97389158
84MP0002233_abnormal_nose_morphology0.96889999
85MP0001324_abnormal_eye_pigmentation0.95734164
86MP0010386_abnormal_urinary_bladder0.94956720
87MP0000049_abnormal_middle_ear0.93061984
88MP0003861_abnormal_nervous_system0.92875799
89MP0001963_abnormal_hearing_physiology0.92791051
90MP0004885_abnormal_endolymph0.92466659
91MP0001929_abnormal_gametogenesis0.92177298
92MP0000604_amyloidosis0.91848595
93MP0002069_abnormal_eating/drinking_beha0.91049343
94MP0000579_abnormal_nail_morphology0.90876844
95MP0006292_abnormal_olfactory_placode0.90815737
96MP0004145_abnormal_muscle_electrophysio0.90768487
97MP0005448_abnormal_energy_balance0.90268508
98MP0001346_abnormal_lacrimal_gland0.90000842
99MP0002653_abnormal_ependyma_morphology0.88935299
100MP0003136_yellow_coat_color0.87937436
101MP0005253_abnormal_eye_physiology0.87812069
102MP0004085_abnormal_heartbeat0.87598267
103MP0002282_abnormal_trachea_morphology0.86528589
104MP0005535_abnormal_body_temperature0.86423263
105MP0005391_vision/eye_phenotype0.86318805
106MP0000462_abnormal_digestive_system0.84478817
107MP0002102_abnormal_ear_morphology0.81250795
108* MP0008874_decreased_physiological_sensi0.80835667
109MP0002210_abnormal_sex_determination0.80076188
110MP0006072_abnormal_retinal_apoptosis0.77912236
111MP0003632_abnormal_nervous_system0.77449451
112MP0002090_abnormal_vision0.72958998
113MP0004215_abnormal_myocardial_fiber0.70908209
114MP0001485_abnormal_pinna_reflex0.67996623
115MP0003634_abnormal_glial_cell0.67841295
116MP0000631_abnormal_neuroendocrine_gland0.67286455
117MP0002638_abnormal_pupillary_reflex0.64546172
118MP0008004_abnormal_stomach_pH0.63828672
119MP0008875_abnormal_xenobiotic_pharmacok0.62668237
120MP0000026_abnormal_inner_ear0.62067709
121MP0001664_abnormal_digestion0.60106176
122MP0003646_muscle_fatigue0.60075799
123MP0005171_absent_coat_pigmentation0.59105092
124MP0001177_atelectasis0.59045040
125MP0005195_abnormal_posterior_eye0.58433844
126MP0008877_abnormal_DNA_methylation0.58337172
127MP0001299_abnormal_eye_distance/0.56880495
128MP0003121_genomic_imprinting0.56844850
129MP0003690_abnormal_glial_cell0.56079474
130MP0005499_abnormal_olfactory_system0.54971671
131MP0005394_taste/olfaction_phenotype0.54971671
132MP0004484_altered_response_of0.51869139
133MP0001943_abnormal_respiration0.51804244
134MP0002082_postnatal_lethality0.50490813
135MP0010770_preweaning_lethality0.50490813
136MP0000013_abnormal_adipose_tissue0.49438080
137MP0010769_abnormal_survival0.48267980

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.25461209
2Atonic seizures (HP:0010819)6.29631770
3Focal seizures (HP:0007359)6.10439905
4Myokymia (HP:0002411)5.72346681
5Febrile seizures (HP:0002373)5.35336895
6Epileptic encephalopathy (HP:0200134)5.09425391
7Absence seizures (HP:0002121)4.94575534
8Dialeptic seizures (HP:0011146)4.49865763
9Generalized tonic-clonic seizures (HP:0002069)4.36314303
10Visual hallucinations (HP:0002367)4.36264255
11Progressive cerebellar ataxia (HP:0002073)4.30844855
12Hyperventilation (HP:0002883)4.26194199
13Severe visual impairment (HP:0001141)3.83092896
14Attenuation of retinal blood vessels (HP:0007843)3.76132732
15Gaze-evoked nystagmus (HP:0000640)3.53209207
16Decreased central vision (HP:0007663)3.53185652
17Ulnar claw (HP:0001178)3.43349849
18Bony spicule pigmentary retinopathy (HP:0007737)3.43282599
19Action tremor (HP:0002345)3.33624159
20Broad-based gait (HP:0002136)3.22718484
21Amblyopia (HP:0000646)3.22012804
22Keratoconus (HP:0000563)3.20783000
23Increased corneal curvature (HP:0100692)3.20783000
24Nephronophthisis (HP:0000090)3.18521444
25Impaired vibration sensation in the lower limbs (HP:0002166)3.17374181
26Pancreatic fibrosis (HP:0100732)3.06925671
27Truncal ataxia (HP:0002078)3.05749617
28Dysdiadochokinesis (HP:0002075)3.01735790
29Molar tooth sign on MRI (HP:0002419)2.99223683
30Abnormality of midbrain morphology (HP:0002418)2.99223683
31True hermaphroditism (HP:0010459)2.97681460
32Status epilepticus (HP:0002133)2.96392463
33Abnormal eating behavior (HP:0100738)2.94904768
34Polyphagia (HP:0002591)2.93241347
35Supranuclear gaze palsy (HP:0000605)2.91147700
36Vaginal atresia (HP:0000148)2.87777770
37Poor eye contact (HP:0000817)2.84512023
38Abnormal social behavior (HP:0012433)2.82546864
39Impaired social interactions (HP:0000735)2.82546864
40Genital tract atresia (HP:0001827)2.82240357
41Epileptiform EEG discharges (HP:0011182)2.82038165
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.81278346
43Dysmetric saccades (HP:0000641)2.80141552
44Urinary bladder sphincter dysfunction (HP:0002839)2.76812577
45Pancreatic cysts (HP:0001737)2.76112250
46Drooling (HP:0002307)2.71162117
47Excessive salivation (HP:0003781)2.71162117
48Depression (HP:0000716)2.67617268
49Short tibia (HP:0005736)2.67498691
50Anxiety (HP:0000739)2.67345047
51Abnormal ciliary motility (HP:0012262)2.67298729
52EEG with generalized epileptiform discharges (HP:0011198)2.66599481
53Limb dystonia (HP:0002451)2.63905620
54Insidious onset (HP:0003587)2.63272065
55Termporal pattern (HP:0011008)2.63272065
56Fetal akinesia sequence (HP:0001989)2.63196300
57Abnormal rod and cone electroretinograms (HP:0008323)2.62025356
58Abnormality of the corticospinal tract (HP:0002492)2.61631869
59Dysmetria (HP:0001310)2.61140055
60Abnormal respiratory motile cilium physiology (HP:0012261)2.60036845
61Poor suck (HP:0002033)2.55436619
62Pheochromocytoma (HP:0002666)2.54794380
63Generalized myoclonic seizures (HP:0002123)2.52779130
64Hypsarrhythmia (HP:0002521)2.52446136
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52291839
66Chronic hepatic failure (HP:0100626)2.51854806
67Blue irides (HP:0000635)2.50133014
68Postural instability (HP:0002172)2.46200624
69Progressive inability to walk (HP:0002505)2.46100396
70Scanning speech (HP:0002168)2.43033427
71Pendular nystagmus (HP:0012043)2.42655510
72Spastic gait (HP:0002064)2.42443081
73Gait imbalance (HP:0002141)2.42139860
74Mutism (HP:0002300)2.41755781
75Impaired vibratory sensation (HP:0002495)2.41628979
76Ankle clonus (HP:0011448)2.41579538
77Abnormality of the renal medulla (HP:0100957)2.39757759
78Lissencephaly (HP:0001339)2.37378300
79Anencephaly (HP:0002323)2.36790021
80Sleep apnea (HP:0010535)2.34641204
81Urinary urgency (HP:0000012)2.34013658
82Impaired smooth pursuit (HP:0007772)2.31160740
83Abnormality of the lower motor neuron (HP:0002366)2.31039853
84Akinesia (HP:0002304)2.29995276
85Abnormal hair whorl (HP:0010721)2.29538743
86Absent speech (HP:0001344)2.29477584
87Neuroendocrine neoplasm (HP:0100634)2.27810867
88Oligodactyly (hands) (HP:0001180)2.27780635
89Cerebral inclusion bodies (HP:0100314)2.27698604
90Neurofibrillary tangles (HP:0002185)2.26968798
91Bradykinesia (HP:0002067)2.24390215
92Inability to walk (HP:0002540)2.23009974
93Concave nail (HP:0001598)2.22852380
94Cutaneous finger syndactyly (HP:0010554)2.22845410
95Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22757331
96Hyperthyroidism (HP:0000836)2.22695509
97Cystic liver disease (HP:0006706)2.20034677
98Torticollis (HP:0000473)2.19719826
99Peripheral hypomyelination (HP:0007182)2.18902435
100Abnormality of binocular vision (HP:0011514)2.18368447
101Diplopia (HP:0000651)2.18368447
102Sensory axonal neuropathy (HP:0003390)2.17924603
103Cutaneous syndactyly (HP:0012725)2.17310394
104Hyperglycinemia (HP:0002154)2.16398233
105Aqueductal stenosis (HP:0002410)2.13471562
106Specific learning disability (HP:0001328)2.13330275
107Failure to thrive in infancy (HP:0001531)2.12738344
108Focal dystonia (HP:0004373)2.09916240
109Genetic anticipation (HP:0003743)2.09662629
110Rhinitis (HP:0012384)2.09467579
111Abnormality of ocular smooth pursuit (HP:0000617)2.08246677
112Cholecystitis (HP:0001082)2.07800571
113Abnormal gallbladder physiology (HP:0012438)2.07800571
114Congenital stationary night blindness (HP:0007642)2.06589887
115Degeneration of the lateral corticospinal tracts (HP:0002314)2.05096418
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05096418
117Hemiparesis (HP:0001269)2.04805225
118Central scotoma (HP:0000603)2.02780444
119Tubulointerstitial nephritis (HP:0001970)2.02705114
120Congenital primary aphakia (HP:0007707)2.02603222
121Abnormality of the labia minora (HP:0012880)2.01500780
122Sclerocornea (HP:0000647)1.97695355
123Esotropia (HP:0000565)1.95851238
124Delusions (HP:0000746)1.95401382
125Spastic tetraplegia (HP:0002510)1.93392342
126Craniofacial dystonia (HP:0012179)1.93201163
127Medial flaring of the eyebrow (HP:0010747)1.93068973
128Psychosis (HP:0000709)1.92435907
129Protruding tongue (HP:0010808)1.91505798
130Abnormality of macular pigmentation (HP:0008002)1.91266257
131Gait ataxia (HP:0002066)1.90707678
132Hypoventilation (HP:0002791)1.90086791
133Abolished electroretinogram (ERG) (HP:0000550)1.89879926
134Generalized hypopigmentation of hair (HP:0011358)1.89054236
135Postural tremor (HP:0002174)1.88851010
136Intestinal atresia (HP:0011100)1.88061848
137Resting tremor (HP:0002322)1.86647969
138Morphological abnormality of the pyramidal tract (HP:0002062)1.86190738
139Postaxial foot polydactyly (HP:0001830)1.84902943
140Abnormal respiratory motile cilium morphology (HP:0005938)1.84014997
141Abnormal respiratory epithelium morphology (HP:0012253)1.84014997
142Agitation (HP:0000713)1.83738073
143Incomplete penetrance (HP:0003829)1.82950967
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.81620534
145Lower limb muscle weakness (HP:0007340)1.81602562
146Preaxial hand polydactyly (HP:0001177)1.80624339
147Nephrogenic diabetes insipidus (HP:0009806)1.80443233
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80154716
149Oligomenorrhea (HP:0000876)1.79506533
150Labial hypoplasia (HP:0000066)1.78975400
151Esophageal atresia (HP:0002032)1.78780346
1523-Methylglutaconic aciduria (HP:0003535)1.78696427
153Absent/shortened dynein arms (HP:0200106)1.77897832
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.77897832
155Occipital encephalocele (HP:0002085)1.75194457
156Poor coordination (HP:0002370)1.75136974
157Aplasia involving bones of the extremities (HP:0009825)1.72701667
158Aplasia involving bones of the upper limbs (HP:0009823)1.72701667
159Aplasia of the phalanges of the hand (HP:0009802)1.72701667
160Congenital malformation of the right heart (HP:0011723)1.71193810
161Double outlet right ventricle (HP:0001719)1.71193810
162Tachypnea (HP:0002789)1.70098893
163Narrow forehead (HP:0000341)1.70043386
164Congenital hepatic fibrosis (HP:0002612)1.69821361
165Postaxial hand polydactyly (HP:0001162)1.68846513
166Bell-shaped thorax (HP:0001591)1.65844128
167Confusion (HP:0001289)1.63495329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.40513465
2CASK3.83764060
3MAP3K43.44556324
4MAP3K93.43855143
5INSRR3.41579830
6MAP3K123.31434658
7MAP2K73.23866390
8EPHA43.09967368
9MARK13.01202005
10FGFR22.98206551
11MAP2K42.55053565
12FRK2.37619415
13MINK12.36824509
14DYRK22.34088644
15RIPK42.25404655
16CDK192.17009543
17DAPK21.95905283
18NTRK21.92272123
19MAPK131.91933392
20PLK21.75539478
21PNCK1.73910612
22PAK61.72497821
23TNIK1.57013400
24PLK41.55400675
25KSR11.54268204
26KSR21.49381436
27SIK21.47240761
28DAPK11.43449518
29BMPR21.42312212
30BMPR1B1.41225533
31OXSR11.40046346
32NTRK11.38305002
33GRK11.37758379
34ARAF1.37253984
35PRKCG1.36719702
36MKNK21.35684328
37LATS21.35040531
38CDK51.31685423
39AKT31.27015405
40GRK51.25858125
41BCKDK1.17539798
42MAPK151.17003883
43PRPF4B1.11527769
44CAMK2A1.11104463
45EPHB21.09653925
46CSNK1G11.06522831
47CSNK1A1L1.01552630
48SGK4941.00219702
49SGK2231.00219702
50CSNK1G30.97938062
51ZAK0.97741151
52UHMK10.96347578
53STK380.96159438
54SGK20.95310789
55CAMKK10.94108311
56MAP3K130.93690752
57SIK30.93420533
58NEK20.92129693
59CCNB10.90685730
60WNK40.85036564
61DMPK0.84847671
62MAP4K20.84129237
63MAP3K60.84097047
64CDK180.83590835
65CDK150.79683443
66DYRK1B0.77239283
67CDK140.76488351
68RAF10.76258901
69PHKG20.75645246
70PHKG10.75645246
71DYRK30.74893364
72RET0.73926166
73PASK0.73026939
74PLK30.72871802
75CSNK1G20.72722541
76PTK2B0.71825181
77TNK20.69319579
78FES0.69168422
79BRAF0.68947330
80NME10.68524790
81CAMK2B0.68485532
82PRKCE0.68025416
83CAMKK20.66356056
84FGR0.65992863
85ADRBK20.65936267
86CDK11A0.65700145
87TLK10.64859228
88ADRBK10.64398906
89BCR0.63257923
90MKNK10.62438124
91PRKCH0.62308918
92DYRK1A0.62277570
93WNK30.62113284
94TRIM280.61237498
95STK110.61070866
96DDR20.61017214
97PAK30.60570903
98TYRO30.60415850
99SGK10.59514551
100CAMK2G0.58567868
101STK38L0.58239684
102SGK30.56592714
103CAMK10.56020571
104MAP3K20.55624288
105MAP2K10.54045393
106MUSK0.50595255
107FER0.50546538
108MARK20.49701642
109PRKCZ0.48586201
110CAMK2D0.47737064
111PINK10.47634464
112CAMK1G0.47402018
113TGFBR10.47258361
114ERBB30.45967121
115PRKD30.45569785
116PDPK10.45285265
117ERBB40.45086193
118PDK10.45066189
119LMTK20.44391637
120NUAK10.44085705
121STK390.44019703
122TSSK60.43513942
123CSNK1E0.43208191
124PRKAA10.42722598
125MYLK0.42326628
126GSK3B0.41625621
127PRKG10.41186042
128RPS6KA30.40864435
129WEE10.40561157
130MAPK120.40542609
131TAOK30.40538720
132PLK10.39834988
133VRK10.39725321
134PRKACB0.38857152
135GRK70.38424174
136PRKCB0.38408551
137PRKG20.38362743
138PRKCA0.35470428
139PKN10.35305900
140MOS0.34473465
141PRKACA0.32322148
142ROCK20.31976330
143MAP3K10.31543734

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21776240
2Synaptic vesicle cycle_Homo sapiens_hsa047213.73474009
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88518214
4GABAergic synapse_Homo sapiens_hsa047272.75487506
5Olfactory transduction_Homo sapiens_hsa047402.63255224
6Morphine addiction_Homo sapiens_hsa050322.60119960
7Phototransduction_Homo sapiens_hsa047442.55558809
8Circadian entrainment_Homo sapiens_hsa047132.45587869
9* Glutamatergic synapse_Homo sapiens_hsa047242.44271313
10Long-term potentiation_Homo sapiens_hsa047202.37044847
11Collecting duct acid secretion_Homo sapiens_hsa049662.24158502
12Amphetamine addiction_Homo sapiens_hsa050312.14796675
13Taste transduction_Homo sapiens_hsa047422.05096831
14Dopaminergic synapse_Homo sapiens_hsa047282.00476956
15Salivary secretion_Homo sapiens_hsa049701.98982153
16Serotonergic synapse_Homo sapiens_hsa047261.88040745
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80263265
18Insulin secretion_Homo sapiens_hsa049111.80110748
19Cholinergic synapse_Homo sapiens_hsa047251.75917077
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65767331
21Renin secretion_Homo sapiens_hsa049241.65475159
22Long-term depression_Homo sapiens_hsa047301.65139746
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57474446
24Gastric acid secretion_Homo sapiens_hsa049711.54655839
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.54073205
26Basal cell carcinoma_Homo sapiens_hsa052171.51011685
27Calcium signaling pathway_Homo sapiens_hsa040201.50430754
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50294052
29Oxytocin signaling pathway_Homo sapiens_hsa049211.42343472
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40747883
31Basal transcription factors_Homo sapiens_hsa030221.40589876
32Hedgehog signaling pathway_Homo sapiens_hsa043401.38877357
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37222143
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32564849
35Vibrio cholerae infection_Homo sapiens_hsa051101.28591973
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28190568
37Linoleic acid metabolism_Homo sapiens_hsa005911.28032297
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27870586
39Cocaine addiction_Homo sapiens_hsa050301.26303686
40Gap junction_Homo sapiens_hsa045401.21628321
41GnRH signaling pathway_Homo sapiens_hsa049121.20869329
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14027279
43Protein export_Homo sapiens_hsa030601.12533411
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10890018
45cAMP signaling pathway_Homo sapiens_hsa040241.10211795
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08206576
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07099039
48Axon guidance_Homo sapiens_hsa043601.05413098
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03984690
50Steroid biosynthesis_Homo sapiens_hsa001001.00516235
51Oxidative phosphorylation_Homo sapiens_hsa001900.96786501
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96506202
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95539289
54Fanconi anemia pathway_Homo sapiens_hsa034600.93872733
55Cardiac muscle contraction_Homo sapiens_hsa042600.91583740
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89970835
57Type II diabetes mellitus_Homo sapiens_hsa049300.88772804
58ErbB signaling pathway_Homo sapiens_hsa040120.88764953
59Propanoate metabolism_Homo sapiens_hsa006400.88068606
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86639230
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.86569282
62Regulation of autophagy_Homo sapiens_hsa041400.86298012
63Retinol metabolism_Homo sapiens_hsa008300.85772664
64Estrogen signaling pathway_Homo sapiens_hsa049150.85258441
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84883645
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81291102
67Melanogenesis_Homo sapiens_hsa049160.80386156
68Caffeine metabolism_Homo sapiens_hsa002320.80297893
69Glioma_Homo sapiens_hsa052140.79675897
70Selenocompound metabolism_Homo sapiens_hsa004500.79122606
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78600332
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78437806
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76821266
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.75582539
75ABC transporters_Homo sapiens_hsa020100.75199580
76Ether lipid metabolism_Homo sapiens_hsa005650.75081934
77Hippo signaling pathway_Homo sapiens_hsa043900.74937300
78Butanoate metabolism_Homo sapiens_hsa006500.73835760
79Alzheimers disease_Homo sapiens_hsa050100.72919293
80Arginine biosynthesis_Homo sapiens_hsa002200.72651045
81Tryptophan metabolism_Homo sapiens_hsa003800.71107000
82Oocyte meiosis_Homo sapiens_hsa041140.66545876
83Bile secretion_Homo sapiens_hsa049760.66535578
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65739358
85Dorso-ventral axis formation_Homo sapiens_hsa043200.63840283
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63541203
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61058429
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59807882
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58445622
90Chemical carcinogenesis_Homo sapiens_hsa052040.57989488
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57864444
92Ovarian steroidogenesis_Homo sapiens_hsa049130.56543673
93MAPK signaling pathway_Homo sapiens_hsa040100.55994982
94Thyroid hormone synthesis_Homo sapiens_hsa049180.54102949
95TGF-beta signaling pathway_Homo sapiens_hsa043500.53960935
96Dilated cardiomyopathy_Homo sapiens_hsa054140.53151034
97Pancreatic secretion_Homo sapiens_hsa049720.52718986
98Ras signaling pathway_Homo sapiens_hsa040140.52439006
99Glucagon signaling pathway_Homo sapiens_hsa049220.51792396
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51603924
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.51347410
102Prion diseases_Homo sapiens_hsa050200.50817028
103Parkinsons disease_Homo sapiens_hsa050120.49119068
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48233912
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48142866
106Nitrogen metabolism_Homo sapiens_hsa009100.46154579
107Fatty acid biosynthesis_Homo sapiens_hsa000610.45591818
108Fatty acid elongation_Homo sapiens_hsa000620.44850926
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44251190
110RNA degradation_Homo sapiens_hsa030180.42358330
111Choline metabolism in cancer_Homo sapiens_hsa052310.41729260
112Rheumatoid arthritis_Homo sapiens_hsa053230.41576127
113Protein digestion and absorption_Homo sapiens_hsa049740.40748471
114Inositol phosphate metabolism_Homo sapiens_hsa005620.40649521
115Histidine metabolism_Homo sapiens_hsa003400.40356556
116Pyruvate metabolism_Homo sapiens_hsa006200.40074510
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39939743
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39181007
119* Phospholipase D signaling pathway_Homo sapiens_hsa040720.38353329
120Phenylalanine metabolism_Homo sapiens_hsa003600.37421166
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36903562
122Peroxisome_Homo sapiens_hsa041460.36782397
123African trypanosomiasis_Homo sapiens_hsa051430.35722141
124Phagosome_Homo sapiens_hsa041450.34529377
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32462327
126Huntingtons disease_Homo sapiens_hsa050160.31943927
127Rap1 signaling pathway_Homo sapiens_hsa040150.31583554
128Circadian rhythm_Homo sapiens_hsa047100.30896103
129VEGF signaling pathway_Homo sapiens_hsa043700.29397707
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.27753148
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25675215
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.25316012
133Alcoholism_Homo sapiens_hsa050340.25255953
134Insulin signaling pathway_Homo sapiens_hsa049100.23967741
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23846842
136Wnt signaling pathway_Homo sapiens_hsa043100.23828925
137Renal cell carcinoma_Homo sapiens_hsa052110.22008446
138Type I diabetes mellitus_Homo sapiens_hsa049400.19775264
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.19749528

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