GRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.84147621
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.84147621
3modulation by symbiont of host immune response (GO:0052553)6.84147621
4positive regulation by symbiont of host defense response (GO:0052509)6.84147621
5modulation by symbiont of host defense response (GO:0052031)6.84147621
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.84147621
7regulation of interferon-beta biosynthetic process (GO:0045357)6.01600189
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09420222
9macrophage activation involved in immune response (GO:0002281)5.08698009
10neutrophil activation involved in immune response (GO:0002283)5.07947717
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.87744298
12positive regulation of interferon-alpha production (GO:0032727)4.76036894
13regulation of interferon-alpha production (GO:0032647)4.52323953
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.44709332
15response to host immune response (GO:0052572)4.38283353
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.38283353
17immunoglobulin mediated immune response (GO:0016064)4.37966255
18microglial cell activation (GO:0001774)4.24233227
19glycosphingolipid catabolic process (GO:0046479)4.20057915
20respiratory burst (GO:0045730)4.08835241
21response to peptidoglycan (GO:0032494)4.07473264
22response to host (GO:0075136)3.99305262
23response to host defenses (GO:0052200)3.99305262
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.99305262
25pinocytosis (GO:0006907)3.98408610
26regulation of cholesterol storage (GO:0010885)3.90276048
27apoptotic cell clearance (GO:0043277)3.83278754
28mannose metabolic process (GO:0006013)3.82473380
29regulation of mononuclear cell migration (GO:0071675)3.79416316
30amino sugar catabolic process (GO:0046348)3.78039805
31glycolipid catabolic process (GO:0019377)3.76266774
32detection of other organism (GO:0098543)3.74180531
33oligosaccharide catabolic process (GO:0009313)3.71986836
34positive regulation of antigen processing and presentation (GO:0002579)3.71968382
35regulation of B cell receptor signaling pathway (GO:0050855)3.70377245
36macrophage activation (GO:0042116)3.68585715
37detection of bacterium (GO:0016045)3.60375742
38positive regulation of gamma-delta T cell activation (GO:0046645)3.55101092
39myeloid cell activation involved in immune response (GO:0002275)3.53940208
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44897805
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44897805
42negative regulation of cell killing (GO:0031342)3.43836157
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43836157
44production of molecular mediator involved in inflammatory response (GO:0002532)3.43175663
45regulation of interleukin-8 biosynthetic process (GO:0045414)3.40540055
46low-density lipoprotein particle clearance (GO:0034383)3.36820823
47negative regulation of erythrocyte differentiation (GO:0045647)3.33379001
48positive regulation of interferon-beta production (GO:0032728)3.30366786
49barbed-end actin filament capping (GO:0051016)3.29269440
50detection of external biotic stimulus (GO:0098581)3.28366099
51ceramide catabolic process (GO:0046514)3.25854776
52cellular response to thyroid hormone stimulus (GO:0097067)3.24990413
53regulation of antigen processing and presentation (GO:0002577)3.23838650
54granulocyte activation (GO:0036230)3.22737929
55NIK/NF-kappaB signaling (GO:0038061)3.22148383
56positive regulation of mast cell activation (GO:0033005)3.21015232
57I-kappaB phosphorylation (GO:0007252)3.19733372
58antigen processing and presentation of endogenous antigen (GO:0019883)3.16953700
59T-helper 1 type immune response (GO:0042088)3.16704413
60hyaluronan catabolic process (GO:0030214)3.15828049
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15791592
62detection of molecule of bacterial origin (GO:0032490)3.15372481
63regulation of mast cell degranulation (GO:0043304)3.14406623
64B cell mediated immunity (GO:0019724)3.14322509
65cellular extravasation (GO:0045123)3.13912860
66myeloid dendritic cell differentiation (GO:0043011)3.12990323
67neutrophil activation (GO:0042119)3.11737529
68protein localization to endosome (GO:0036010)3.07280531
69lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05200298
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.03176894
71keratan sulfate catabolic process (GO:0042340)3.01219423
72hydrogen peroxide biosynthetic process (GO:0050665)3.00767133
73negative regulation of cytokine production involved in immune response (GO:0002719)2.97550308
74response to interferon-alpha (GO:0035455)2.97509141
75positive regulation of leukocyte degranulation (GO:0043302)2.97163983
76positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97035639
77regulation of mast cell activation involved in immune response (GO:0033006)2.95586979
78N-acetylneuraminate metabolic process (GO:0006054)2.95441456
79regulation of superoxide anion generation (GO:0032928)2.90515322
80positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.90504769
81response to thyroid hormone (GO:0097066)2.87427591
82detection of biotic stimulus (GO:0009595)2.86802729
83regulation of podosome assembly (GO:0071801)2.86261214
84germinal center formation (GO:0002467)2.86128754
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85853936
86negative regulation of granulocyte differentiation (GO:0030853)2.85460111
87regulation of mast cell activation (GO:0033003)2.85277015
88regulation of leukocyte degranulation (GO:0043300)2.83123445
89positive regulation of mast cell degranulation (GO:0043306)2.83065825
90positive regulation of mast cell activation involved in immune response (GO:0033008)2.83065825
91myeloid dendritic cell activation (GO:0001773)2.82761978
92response to muramyl dipeptide (GO:0032495)2.82356157
93regulation of macrophage chemotaxis (GO:0010758)2.82056344
94positive regulation of B cell differentiation (GO:0045579)2.80490944
95membrane lipid catabolic process (GO:0046466)2.80083040
96positive regulation of cellular amide metabolic process (GO:0034250)2.79666697
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78941906
98response to laminar fluid shear stress (GO:0034616)2.77476908
99sphingolipid catabolic process (GO:0030149)2.77180314
100positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.75145939
101negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.74952503
102regulation of T-helper 2 cell differentiation (GO:0045628)2.74441993
103negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72661005
104peptide catabolic process (GO:0043171)2.70216337
105negative regulation of interleukin-6 production (GO:0032715)2.69890563
106negative regulation of mast cell activation (GO:0033004)2.69494866
107virion attachment to host cell (GO:0019062)2.68152726
108adhesion of symbiont to host cell (GO:0044650)2.68152726
109natural killer cell mediated immunity (GO:0002228)2.66813720
110natural killer cell mediated cytotoxicity (GO:0042267)2.66813720
111lymphocyte chemotaxis (GO:0048247)2.66306894
112reactive oxygen species biosynthetic process (GO:1903409)2.66105249
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65976823
114regulation of phagocytosis (GO:0050764)2.64637703
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.64548960
116regulation of vitamin D biosynthetic process (GO:0060556)2.63976907
117positive regulation of chemokine biosynthetic process (GO:0045080)2.63860235
118cell adhesion mediated by integrin (GO:0033627)2.62820223
119type I interferon signaling pathway (GO:0060337)2.62522115
120cellular response to type I interferon (GO:0071357)2.62522115
121positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61471310
122response to type I interferon (GO:0034340)2.61315471
123regulation of macrophage cytokine production (GO:0010935)2.59998183
124positive regulation of monocyte chemotaxis (GO:0090026)2.59996735
125neutrophil mediated immunity (GO:0002446)2.58695806
126myeloid leukocyte activation (GO:0002274)2.58553417
127regulation of regulated secretory pathway (GO:1903305)2.58454681
128regulation of interferon-beta production (GO:0032648)2.58299125
129negative regulation of interleukin-12 production (GO:0032695)2.57095024
130lipoprotein transport (GO:0042953)2.56879581
131superoxide anion generation (GO:0042554)2.56847278
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55948039
133regulation of cytokine secretion involved in immune response (GO:0002739)2.54919361
134regulation of chemokine biosynthetic process (GO:0045073)2.54832448
135dendritic cell differentiation (GO:0097028)2.54513007
136cellular response to interferon-alpha (GO:0035457)2.54335229
137positive regulation of macrophage cytokine production (GO:0060907)2.53870926
138positive regulation of phagocytosis (GO:0050766)2.53696157
139positive regulation of Cdc42 GTPase activity (GO:0043089)2.53447827
140interferon-gamma-mediated signaling pathway (GO:0060333)2.52198489
141negative regulation of lipid storage (GO:0010888)2.50861685
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50670850
143amyloid precursor protein catabolic process (GO:0042987)2.50168135
144regulation of integrin activation (GO:0033623)2.50053422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_21731497_ChIP-ChIP_J774_Mouse5.91905804
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.04998207
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.72360021
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.20568294
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.90263441
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57221064
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.38350153
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.06447954
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.06275421
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01960094
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91024653
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65807178
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55889262
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53000271
15* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.35155814
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23556719
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20859151
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08890028
19SPI1_23547873_ChIP-Seq_NB4_Human2.07388748
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01674428
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00363369
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.97656412
23SPI1_23127762_ChIP-Seq_K562_Human1.95414552
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83655859
25VDR_21846776_ChIP-Seq_THP-1_Human1.81988475
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80082601
27VDR_24763502_ChIP-Seq_THP-1_Human1.77825478
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76217977
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73294883
30* RXR_22158963_ChIP-Seq_LIVER_Mouse1.72714066
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70054602
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69566914
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69498707
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65296148
35* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63564330
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.63521250
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61949505
38* PU_27001747_Chip-Seq_BMDM_Mouse1.60588477
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59270736
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.58232943
41SCL_19346495_ChIP-Seq_HPC-7_Human1.56541495
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56236442
43MAF_26560356_Chip-Seq_TH1_Human1.55465867
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50595780
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50561884
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50172007
47* LXR_22158963_ChIP-Seq_LIVER_Mouse1.45992336
48VDR_24787735_ChIP-Seq_THP-1_Human1.45458118
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44953360
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.44222200
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42880636
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42608644
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38230756
54MYB_26560356_Chip-Seq_TH2_Human1.37773698
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37525447
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.36677526
57* TFEB_21752829_ChIP-Seq_HELA_Human1.35801807
58RUNX_20019798_ChIP-Seq_JUKART_Human1.35716501
59* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34947747
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34132032
61CLOCK_20551151_ChIP-Seq_293T_Human1.31892978
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28368935
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28020638
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26610742
65GATA1_22025678_ChIP-Seq_K562_Human1.24548889
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23411847
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22286186
68MAF_26560356_Chip-Seq_TH2_Human1.20816400
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18881862
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.18652709
71BCOR_27268052_Chip-Seq_Bcells_Human1.17161086
72* LXR_22292898_ChIP-Seq_THP-1_Human1.15750180
73MYB_26560356_Chip-Seq_TH1_Human1.14375499
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14372203
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14337729
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13726670
77BCL6_27268052_Chip-Seq_Bcells_Human1.13473937
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13112759
79UTX_26944678_Chip-Seq_JUKART_Human1.12758157
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12734881
81MYC_22102868_ChIP-Seq_BL_Human1.11884881
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11558216
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11477567
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11259904
85KDM2B_26808549_Chip-Seq_K562_Human1.11109840
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10800030
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10762995
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.08705020
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08106198
90ZNF263_19887448_ChIP-Seq_K562_Human1.07269783
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.06537708
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05137819
93* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04864704
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04777126
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04452822
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.03681182
97NCOR1_26117541_ChIP-Seq_K562_Human1.03068915
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02500698
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02390314
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00729606
101KDM2B_26808549_Chip-Seq_DND41_Human1.00326288
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99288429
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98806050
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97025337
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95141338
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94349141
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93279720
108ESR1_21235772_ChIP-Seq_MCF-7_Human0.92191619
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.90714914
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90249335
111GATA3_27048872_Chip-Seq_THYMUS_Human0.90099969
112RACK7_27058665_Chip-Seq_MCF-7_Human0.87138842
113GATA1_19941826_ChIP-Seq_K562_Human0.86844493
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86438932
115SPI1_20517297_ChIP-Seq_HL60_Human0.86316298
116GATA3_26560356_Chip-Seq_TH2_Human0.86244372
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85610520
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85344954
119* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84382101
120GATA2_19941826_ChIP-Seq_K562_Human0.82985727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.12449674
2MP0003303_peritoneal_inflammation3.56863327
3MP0001835_abnormal_antigen_presentation3.36743543
4MP0003436_decreased_susceptibility_to3.36407875
5MP0006082_CNS_inflammation3.22465290
6MP0009840_abnormal_foam_cell3.22026851
7MP0003172_abnormal_lysosome_physiology3.12929421
8* MP0002419_abnormal_innate_immunity2.70543083
9MP0003191_abnormal_cellular_cholesterol2.65954651
10MP0008438_abnormal_cutaneous_collagen2.51468253
11MP0002148_abnormal_hypersensitivity_rea2.37200560
12MP0005000_abnormal_immune_tolerance2.31422457
13MP0003300_gastrointestinal_ulcer2.18477410
14MP0005387_immune_system_phenotype2.17229523
15MP0001790_abnormal_immune_system2.17229523
16MP0003724_increased_susceptibility_to2.16180711
17MP0009785_altered_susceptibility_to2.14654451
18MP0001533_abnormal_skeleton_physiology2.14370422
19* MP0005025_abnormal_response_to2.13940614
20MP0005451_abnormal_body_composition2.12026719
21MP0005464_abnormal_platelet_physiology2.10207532
22* MP0002452_abnormal_antigen_presenting2.06379998
23MP0001800_abnormal_humoral_immune1.89271329
24MP0000343_altered_response_to1.88723248
25MP0000685_abnormal_immune_system1.88427873
26MP0000604_amyloidosis1.88224060
27MP0008260_abnormal_autophagy1.83397063
28MP0003705_abnormal_hypodermis_morpholog1.81417462
29MP0005257_abnormal_intraocular_pressure1.79734406
30* MP0002723_abnormal_immune_serum1.77593152
31MP0004510_myositis1.77166903
32MP0002139_abnormal_hepatobiliary_system1.71887922
33* MP0001819_abnormal_immune_cell1.60604289
34* MP0002420_abnormal_adaptive_immunity1.58995922
35MP0003448_altered_tumor_morphology1.58712999
36MP0003566_abnormal_cell_adhesion1.58458947
37MP0004947_skin_inflammation1.55357554
38MP0001845_abnormal_inflammatory_respons1.55200472
39MP0003075_altered_response_to1.52402837
40MP0008469_abnormal_protein_level1.51299901
41MP0002405_respiratory_system_inflammati1.51173384
42MP0003806_abnormal_nucleotide_metabolis1.47430661
43MP0009278_abnormal_bone_marrow1.46536156
44MP0010307_abnormal_tumor_latency1.40087351
45MP0002998_abnormal_bone_remodeling1.39842409
46MP0005671_abnormal_response_to1.39495848
47MP0001958_emphysema1.31731808
48MP0000858_altered_metastatic_potential1.30525752
49MP0002877_abnormal_melanocyte_morpholog1.30366130
50MP0009764_decreased_sensitivity_to1.26630977
51* MP0003690_abnormal_glial_cell1.26622570
52MP0005310_abnormal_salivary_gland1.25227767
53MP0001851_eye_inflammation1.24038440
54MP0008004_abnormal_stomach_pH1.23137113
55MP0003329_amyloid_beta_deposits1.23131218
56MP0003183_abnormal_peptide_metabolism1.22721682
57MP0010155_abnormal_intestine_physiology1.22109210
58MP0009333_abnormal_splenocyte_physiolog1.16849018
59MP0005390_skeleton_phenotype1.16303395
60MP0000689_abnormal_spleen_morphology1.16098769
61MP0005166_decreased_susceptibility_to1.15245770
62* MP0000716_abnormal_immune_system1.15151716
63MP0000569_abnormal_digit_pigmentation1.14325374
64MP0000465_gastrointestinal_hemorrhage1.12794377
65MP0001853_heart_inflammation1.11730286
66MP0001849_ear_inflammation1.09734382
67MP0005164_abnormal_response_to1.08998036
68MP0002933_joint_inflammation1.06833838
69MP0005023_abnormal_wound_healing1.04670933
70MP0005397_hematopoietic_system_phenotyp1.03792567
71MP0001545_abnormal_hematopoietic_system1.03792567
72MP0003656_abnormal_erythrocyte_physiolo1.03500764
73MP0002398_abnormal_bone_marrow1.01332647
74MP0003279_aneurysm0.99812773
75* MP0002429_abnormal_blood_cell0.97607494
76MP0003828_pulmonary_edema0.97586717
77MP0002166_altered_tumor_susceptibility0.96511597
78MP0002722_abnormal_immune_system0.95195427
79MP0000249_abnormal_blood_vessel0.94679457
80MP0005076_abnormal_cell_differentiation0.93662081
81MP0005083_abnormal_biliary_tract0.92467578
82MP0009763_increased_sensitivity_to0.91338416
83MP0000920_abnormal_myelination0.89293813
84MP0000609_abnormal_liver_physiology0.89078687
85MP0000767_abnormal_smooth_muscle0.88525767
86MP0003091_abnormal_cell_migration0.87564496
87MP0002254_reproductive_system_inflammat0.84033618
88MP0004883_abnormal_blood_vessel0.82997275
89MP0003795_abnormal_bone_structure0.82345269
90MP0002090_abnormal_vision0.82286802
91MP0010329_abnormal_lipoprotein_level0.82283426
92MP0003186_abnormal_redox_activity0.80844838
93MP0005167_abnormal_blood-brain_barrier0.80741565
94MP0005365_abnormal_bile_salt0.79963246
95MP0005275_abnormal_skin_tensile0.79754575
96MP0002138_abnormal_hepatobiliary_system0.78999467
97MP0000598_abnormal_liver_morphology0.77705139
98MP0004185_abnormal_adipocyte_glucose0.77626985
99MP0002136_abnormal_kidney_physiology0.77073038
100MP0004782_abnormal_surfactant_physiolog0.75642018
101MP0005319_abnormal_enzyme/_coenzyme0.75335453
102MP0004130_abnormal_muscle_cell0.75257264
103MP0004858_abnormal_nervous_system0.75198479
104MP0000490_abnormal_crypts_of0.75129556
105MP0003195_calcinosis0.74015582
106MP0003453_abnormal_keratinocyte_physiol0.73421472
107MP0001915_intracranial_hemorrhage0.72998560
108MP0001663_abnormal_digestive_system0.72627430
109MP0005670_abnormal_white_adipose0.72508656
110MP0005174_abnormal_tail_pigmentation0.70304287
111* MP0005165_increased_susceptibility_to0.70133352
112MP0001542_abnormal_bone_strength0.69740201
113MP0002006_tumorigenesis0.69722064
114MP0006054_spinal_hemorrhage0.67924372
115MP0010234_abnormal_vibrissa_follicle0.66693594
116MP0003763_abnormal_thymus_physiology0.65154265
117MP0003634_abnormal_glial_cell0.64987557
118MP0000371_diluted_coat_color0.63921701
119MP0008874_decreased_physiological_sensi0.62265119

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.50209222
2Systemic lupus erythematosus (HP:0002725)6.19068105
3Vacuolated lymphocytes (HP:0001922)6.06083556
4Recurrent abscess formation (HP:0002722)5.77006944
5Increased neuronal autofluorescent lipopigment (HP:0002074)5.70225033
6Dysostosis multiplex (HP:0000943)5.38183889
7Eczematoid dermatitis (HP:0000976)5.28230487
8Recurrent bacterial skin infections (HP:0005406)5.20310255
9Recurrent gram-negative bacterial infections (HP:0005420)4.91593785
10Abnormality of liposaccharide metabolism (HP:0010968)4.60351700
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.60351700
12Abnormality of glycolipid metabolism (HP:0010969)4.60351700
13Abnormality of macrophages (HP:0004311)4.48253833
14Mucopolysacchariduria (HP:0008155)4.47764013
15Urinary glycosaminoglycan excretion (HP:0003541)4.47764013
16Glomerulonephritis (HP:0000099)4.38333979
17Abnormality of mucopolysaccharide metabolism (HP:0011020)4.21295271
18Abnormality of polysaccharide metabolism (HP:0011012)4.21295271
19Abnormality of glycosaminoglycan metabolism (HP:0004371)4.21295271
20Axonal loss (HP:0003447)4.05051464
21Loss of speech (HP:0002371)3.54756372
22Complement deficiency (HP:0004431)3.50052511
23Abnormality of complement system (HP:0005339)3.41711083
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.35933048
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.27034500
26Myocardial infarction (HP:0001658)3.13242856
27Nuclear cataract (HP:0100018)3.04890097
28Neurofibrillary tangles (HP:0002185)3.04791979
29Gingivitis (HP:0000230)3.02697440
30Recurrent skin infections (HP:0001581)3.02536732
31Purpura (HP:0000979)2.96718022
32Nephritis (HP:0000123)2.87951330
33Myositis (HP:0100614)2.86643194
34Obstructive lung disease (HP:0006536)2.86148788
35Chronic obstructive pulmonary disease (HP:0006510)2.86148788
36Mediastinal lymphadenopathy (HP:0100721)2.82992195
37Asymmetric septal hypertrophy (HP:0001670)2.78460410
38Agnosia (HP:0010524)2.76663521
39Pustule (HP:0200039)2.65608867
40J-shaped sella turcica (HP:0002680)2.65183598
41Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62948891
42Interstitial pulmonary disease (HP:0006530)2.61088716
43Elevated erythrocyte sedimentation rate (HP:0003565)2.56127245
44Vertebral compression fractures (HP:0002953)2.55985527
45Upper motor neuron abnormality (HP:0002127)2.55709733
46Hepatosplenomegaly (HP:0001433)2.54857825
47Cellulitis (HP:0100658)2.54656809
48* Disinhibition (HP:0000734)2.52299916
49Cerebral aneurysm (HP:0004944)2.51616756
50Thoracic kyphosis (HP:0002942)2.50385770
51Pathologic fracture (HP:0002756)2.50311278
52Abnormality of the lumbar spine (HP:0100712)2.47377122
53Autoimmune thrombocytopenia (HP:0001973)2.46748039
54Orchitis (HP:0100796)2.45271508
55Recurrent fungal infections (HP:0002841)2.42697523
56Basal ganglia calcification (HP:0002135)2.41221719
57Cervical subluxation (HP:0003308)2.38751021
58Spontaneous hematomas (HP:0007420)2.36234293
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.35939323
60Osteolytic defects of the hand bones (HP:0009699)2.35939323
61Hematochezia (HP:0002573)2.34297682
62Cerebral inclusion bodies (HP:0100314)2.31466784
63Urticaria (HP:0001025)2.30211928
64Conjunctival telangiectasia (HP:0000524)2.29528027
65Spondylolisthesis (HP:0003302)2.25354458
66Premature rupture of membranes (HP:0001788)2.20547689
67Periodontitis (HP:0000704)2.20081428
68Thick nail (HP:0001805)2.18525804
69Prolonged neonatal jaundice (HP:0006579)2.17666857
70Joint hemorrhage (HP:0005261)2.17313077
71Pulmonary infiltrates (HP:0002113)2.16016129
72Chronic otitis media (HP:0000389)2.15894132
73Recurrent viral infections (HP:0004429)2.14952082
74Prostate neoplasm (HP:0100787)2.09892699
75Osteomyelitis (HP:0002754)2.08492689
76Joint stiffness (HP:0001387)2.07967021
77Increased IgE level (HP:0003212)2.06801405
78Peripheral demyelination (HP:0011096)2.05519443
79Malnutrition (HP:0004395)2.04249117
80Meningitis (HP:0001287)2.02293785
81Ovoid vertebral bodies (HP:0003300)2.02137011
82Peritonitis (HP:0002586)2.01306336
83Bone pain (HP:0002653)2.00693992
84Beaking of vertebral bodies (HP:0004568)2.00343704
85Abnormality of iron homeostasis (HP:0011031)1.98433936
86Retinal atrophy (HP:0001105)1.97830486
87* Neuronal loss in central nervous system (HP:0002529)1.97255831
88Cardiomegaly (HP:0001640)1.97129076
89* Progressive neurologic deterioration (HP:0002344)1.96580733
90Stomatitis (HP:0010280)1.92757219
91Supranuclear gaze palsy (HP:0000605)1.90267675
92Hemoptysis (HP:0002105)1.89873564
93Global brain atrophy (HP:0002283)1.89602555
94Tetraparesis (HP:0002273)1.87378621
95Petechiae (HP:0000967)1.87252961
96Restrictive lung disease (HP:0002091)1.86486935
97Progressive visual loss (HP:0000529)1.86088682
98Colitis (HP:0002583)1.86038185
99Gingival bleeding (HP:0000225)1.83911861
100Abnormality of the thoracic spine (HP:0100711)1.83464391
101Deformed sella turcica (HP:0002681)1.83322722
102Esophageal varix (HP:0002040)1.82883403
103Keratoconjunctivitis sicca (HP:0001097)1.81122021
104Abnormality of the nasal mucosa (HP:0000433)1.80784918
105Increased serum ferritin (HP:0003281)1.77638015
106Xanthomatosis (HP:0000991)1.76210638
107Premature loss of primary teeth (HP:0006323)1.75938710
108Amyloidosis (HP:0011034)1.75788477
109Recurrent pneumonia (HP:0006532)1.75454475
110Vasculitis (HP:0002633)1.74605656
111* Dementia (HP:0000726)1.74146280
112Polygenic inheritance (HP:0010982)1.74106365
113* Diminished motivation (HP:0000745)1.73825946
114Hypergammaglobulinemia (HP:0010702)1.73415786
115Epistaxis (HP:0000421)1.73325758
116Acrocyanosis (HP:0001063)1.73283038
117Distal lower limb muscle weakness (HP:0009053)1.72912649
118Nasal polyposis (HP:0100582)1.72416073
119Mucosal telangiectasiae (HP:0100579)1.72241072
120Arterial tortuosity (HP:0005116)1.71436061
121* Apathy (HP:0000741)1.70263257
122Inflammation of the large intestine (HP:0002037)1.70062766
123Increased CSF protein (HP:0002922)1.68197687
124Arterial thrombosis (HP:0004420)1.67522780
125Retrobulbar optic neuritis (HP:0100654)1.67330045
126Optic neuritis (HP:0100653)1.67330045
127Polyneuropathy (HP:0001271)1.67296667
128Gastrointestinal stroma tumor (HP:0100723)1.66800886
129Metaphyseal irregularity (HP:0003025)1.64123678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.03515192
2BLK3.88777131
3TGFBR23.20279502
4KIT3.00177720
5TBK12.94346853
6TYK22.84137147
7TRIB32.81383855
8IRAK42.63462627
9PRPF4B2.56092897
10RIPK42.46499626
11MAP4K12.33093150
12TAOK22.10773256
13CSF1R2.09161169
14PIM22.00219466
15NME21.97901428
16IRAK31.94249036
17PKN21.92313315
18EPHB11.88783858
19TAOK11.84737667
20TAOK31.83115838
21MAP3K141.82219160
22DDR21.73094666
23CAMK1D1.64460871
24IKBKB1.62828917
25NEK91.59412656
26JAK11.58837095
27IKBKE1.53621176
28CSK1.52250687
29ZAP701.52066829
30PAK41.50862329
31STK101.49971795
32MAP2K31.47581839
33TTN1.42478114
34CDC42BPA1.36119577
35HCK1.34598028
36RIPK11.33171585
37JAK31.30220395
38SCYL21.24732307
39MAP3K11.22766198
40PTK61.22253195
41LRRK21.17370056
42FES1.16518271
43BTK1.14655775
44SMG11.14013284
45SYK1.12057643
46FGR1.11219148
47BMX1.11039379
48RPS6KA41.08768678
49ABL21.07134485
50ICK1.06426877
51LYN1.02738834
52FGFR41.00528773
53JAK21.00377663
54BMPR21.00055144
55MATK0.99406869
56SIK30.97977158
57MAP3K30.97386968
58CAMKK20.96811770
59ARAF0.95927860
60CAMK1G0.95318476
61CDK60.91680887
62LCK0.88729931
63TNK20.88241164
64DMPK0.84633385
65PRKD20.83280632
66TEC0.82209878
67GRK70.81312761
68ITK0.80245041
69IRAK20.76420225
70PIM10.76350098
71PBK0.74652902
72EPHA20.74224442
73MOS0.73773831
74EGFR0.73163628
75PDGFRA0.72681207
76CHUK0.72655033
77MST1R0.72283810
78MAP3K110.71562184
79RPS6KA20.70634772
80KDR0.69601321
81SIK10.64879334
82ABL10.64497125
83CAMKK10.64450958
84MAP3K50.64396323
85MAP3K60.64157874
86TRPM70.63695634
87EPHB20.63551945
88MARK30.61598465
89RPS6KL10.59947859
90RPS6KC10.59947859
91EPHA30.59866443
92MARK20.59006285
93MAPK70.58571325
94KSR20.58182893
95FLT30.57980405
96PRKG20.57402112
97CLK10.55753217
98PIK3CG0.55722735
99GSK3A0.55426500
100PDK10.55385593
101LIMK10.54342121
102PRKCD0.53880195
103FGFR30.53780627
104MAP3K130.52089206
105STK30.50295547
106TESK20.49045860
107MAP2K60.48274815
108GRK60.46963070
109HIPK20.46163302
110MAP3K100.45360899
111MAPKAPK20.43810360
112MAP3K80.42859082
113DYRK1B0.42192342
114PAK20.38855615
115IGF1R0.37676360
116DAPK30.37673082
117MAPK120.37636661
118STK40.36727532
119IRAK10.36139656
120MAPK40.34338672
121TXK0.33956887
122PDPK10.33237822
123MAP2K20.33017680
124SIK20.32971647
125TESK10.32612838
126FYN0.31900721
127RPS6KA60.31233532
128PAK10.30515684
129PDGFRB0.29836763
130PTK20.29205194
131PTK2B0.27589655

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.49797825
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.39490514
3Lysosome_Homo sapiens_hsa041423.83366384
4Other glycan degradation_Homo sapiens_hsa005113.58515747
5Leishmaniasis_Homo sapiens_hsa051402.89936934
6Osteoclast differentiation_Homo sapiens_hsa043802.43229575
7Pertussis_Homo sapiens_hsa051332.29088009
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29046241
9Complement and coagulation cascades_Homo sapiens_hsa046102.08222531
10Tuberculosis_Homo sapiens_hsa051522.07653468
11Malaria_Homo sapiens_hsa051442.02191983
12Phagosome_Homo sapiens_hsa041452.00014680
13Autoimmune thyroid disease_Homo sapiens_hsa053201.92451684
14Legionellosis_Homo sapiens_hsa051341.77096145
15Antigen processing and presentation_Homo sapiens_hsa046121.76333877
16B cell receptor signaling pathway_Homo sapiens_hsa046621.65168886
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59484552
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.55110538
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51712189
20Rheumatoid arthritis_Homo sapiens_hsa053231.49007056
21Type I diabetes mellitus_Homo sapiens_hsa049401.44829811
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44012663
23Caffeine metabolism_Homo sapiens_hsa002321.43504097
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42829087
25Toxoplasmosis_Homo sapiens_hsa051451.41130918
26Measles_Homo sapiens_hsa051621.38012233
27Salmonella infection_Homo sapiens_hsa051321.31784006
28Apoptosis_Homo sapiens_hsa042101.31691979
29Shigellosis_Homo sapiens_hsa051311.31495671
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25241480
31Influenza A_Homo sapiens_hsa051641.22609306
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22530663
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21569371
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18770722
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11433498
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.10541681
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09621737
38TNF signaling pathway_Homo sapiens_hsa046681.07877731
39Bladder cancer_Homo sapiens_hsa052191.07152273
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06628703
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05628562
42Amoebiasis_Homo sapiens_hsa051461.05116136
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02551979
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96665633
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96636704
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.96516625
47Prion diseases_Homo sapiens_hsa050200.93608124
48Pancreatic cancer_Homo sapiens_hsa052120.91824567
49Vibrio cholerae infection_Homo sapiens_hsa051100.91501951
50Chemokine signaling pathway_Homo sapiens_hsa040620.90900806
51Chronic myeloid leukemia_Homo sapiens_hsa052200.89796170
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89774157
53Hematopoietic cell lineage_Homo sapiens_hsa046400.87923742
54Hepatitis B_Homo sapiens_hsa051610.87629214
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.87236659
56Renin-angiotensin system_Homo sapiens_hsa046140.85244541
57Asthma_Homo sapiens_hsa053100.84267733
58Hepatitis C_Homo sapiens_hsa051600.83980056
59Herpes simplex infection_Homo sapiens_hsa051680.81956184
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81292665
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77336893
62Sphingolipid metabolism_Homo sapiens_hsa006000.75360562
63Platelet activation_Homo sapiens_hsa046110.71869003
64Viral myocarditis_Homo sapiens_hsa054160.71583567
65Acute myeloid leukemia_Homo sapiens_hsa052210.70972547
66Fructose and mannose metabolism_Homo sapiens_hsa000510.70149954
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64396174
68Endocytosis_Homo sapiens_hsa041440.62804078
69Primary immunodeficiency_Homo sapiens_hsa053400.62717936
70PPAR signaling pathway_Homo sapiens_hsa033200.60124816
71Proteoglycans in cancer_Homo sapiens_hsa052050.59589768
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59107858
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54461066
74Galactose metabolism_Homo sapiens_hsa000520.53506905
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53336790
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.53298002
77Graft-versus-host disease_Homo sapiens_hsa053320.53070734
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52747268
79HIF-1 signaling pathway_Homo sapiens_hsa040660.51550259
80African trypanosomiasis_Homo sapiens_hsa051430.51491060
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50402931
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.47772565
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.47704552
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.47483911
85Steroid biosynthesis_Homo sapiens_hsa001000.46990489
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46736068
87Starch and sucrose metabolism_Homo sapiens_hsa005000.45737726
88Small cell lung cancer_Homo sapiens_hsa052220.45285865
89Nitrogen metabolism_Homo sapiens_hsa009100.44867935
90HTLV-I infection_Homo sapiens_hsa051660.44162977
91Pentose phosphate pathway_Homo sapiens_hsa000300.43092581
92Focal adhesion_Homo sapiens_hsa045100.42339377
93Collecting duct acid secretion_Homo sapiens_hsa049660.38709545
94Non-small cell lung cancer_Homo sapiens_hsa052230.38555110
95Mineral absorption_Homo sapiens_hsa049780.38202422
96Arginine biosynthesis_Homo sapiens_hsa002200.37739192
97Allograft rejection_Homo sapiens_hsa053300.36995578
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.36196279
99GnRH signaling pathway_Homo sapiens_hsa049120.35893605
100Insulin resistance_Homo sapiens_hsa049310.35275211
101VEGF signaling pathway_Homo sapiens_hsa043700.34411838
102ABC transporters_Homo sapiens_hsa020100.33780540
103Histidine metabolism_Homo sapiens_hsa003400.33261215
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.31201409
105Sulfur metabolism_Homo sapiens_hsa009200.31027909
106ECM-receptor interaction_Homo sapiens_hsa045120.30350654
107N-Glycan biosynthesis_Homo sapiens_hsa005100.29809733
108Notch signaling pathway_Homo sapiens_hsa043300.29081736
109Prolactin signaling pathway_Homo sapiens_hsa049170.28815192
110Viral carcinogenesis_Homo sapiens_hsa052030.28798836
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28597202
112T cell receptor signaling pathway_Homo sapiens_hsa046600.28225283
113Adherens junction_Homo sapiens_hsa045200.26031404
114Renal cell carcinoma_Homo sapiens_hsa052110.25733067
115Epstein-Barr virus infection_Homo sapiens_hsa051690.25439188
116Systemic lupus erythematosus_Homo sapiens_hsa053220.24671113
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22564284

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