GRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dorsal/ventral neural tube patterning (GO:0021904)5.32836824
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23062848
3negative regulation of hormone biosynthetic process (GO:0032353)5.21716332
4embryonic retina morphogenesis in camera-type eye (GO:0060059)5.18986181
5vocalization behavior (GO:0071625)5.04058241
6synaptic vesicle exocytosis (GO:0016079)5.03617744
7gonadal mesoderm development (GO:0007506)4.93065623
8neuron cell-cell adhesion (GO:0007158)4.89737800
9somite rostral/caudal axis specification (GO:0032525)4.89361710
10protein localization to synapse (GO:0035418)4.81462797
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.79993343
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79052172
13cell migration involved in gastrulation (GO:0042074)4.78032370
14negative regulation of hormone metabolic process (GO:0032351)4.76746642
15proline transport (GO:0015824)4.75067516
16regulation of mesoderm development (GO:2000380)4.73062634
17primitive streak formation (GO:0090009)4.72963061
18glutamate receptor signaling pathway (GO:0007215)4.69313546
19regulation of glutamate receptor signaling pathway (GO:1900449)4.68807604
20muscle organ morphogenesis (GO:0048644)4.67541428
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.60707364
22behavioral fear response (GO:0001662)4.55231848
23behavioral defense response (GO:0002209)4.55231848
24negative regulation of activin receptor signaling pathway (GO:0032926)4.47902950
25protein localization to kinetochore (GO:0034501)4.45034562
26signal transduction involved in regulation of gene expression (GO:0023019)4.43146178
27dopamine biosynthetic process (GO:0042416)4.39548274
28neuron recognition (GO:0008038)4.28728685
29mitotic sister chromatid cohesion (GO:0007064)4.26968700
30anterior/posterior axis specification (GO:0009948)4.23014017
31fear response (GO:0042596)4.22946353
32regulation of glutamate secretion (GO:0014048)4.20262897
33adrenergic receptor signaling pathway (GO:0071875)4.17999291
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09289042
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05605293
36anterior/posterior axis specification, embryo (GO:0008595)4.04669673
37signal peptide processing (GO:0006465)4.02883399
38negative regulation of osteoblast proliferation (GO:0033689)4.01487507
39musculoskeletal movement (GO:0050881)4.01470999
40multicellular organismal movement (GO:0050879)4.01470999
41synaptic vesicle endocytosis (GO:0048488)4.00182454
42exploration behavior (GO:0035640)4.00136284
43dopamine transport (GO:0015872)3.99689631
44neuron-neuron synaptic transmission (GO:0007270)3.98991941
45response to histamine (GO:0034776)3.95215349
46microtubule depolymerization (GO:0007019)3.93236638
47retina layer formation (GO:0010842)3.88202822
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.87502360
49synaptic transmission, glutamatergic (GO:0035249)3.87014292
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84968086
51neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.84150579
52presynaptic membrane assembly (GO:0097105)3.82410536
53peripheral nervous system neuron development (GO:0048935)3.78665416
54regulation of neuronal synaptic plasticity (GO:0048168)3.76994271
55glutamate secretion (GO:0014047)3.76282827
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75097760
57regulation of postsynaptic membrane potential (GO:0060078)3.74820327
58axonal fasciculation (GO:0007413)3.73767660
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71538241
60positive regulation of neurotransmitter secretion (GO:0001956)3.70614544
61phospholipid scrambling (GO:0017121)3.69210558
62pre-miRNA processing (GO:0031054)3.69007743
63regulation of inositol phosphate biosynthetic process (GO:0010919)3.67845036
64limb development (GO:0060173)3.66748649
65appendage development (GO:0048736)3.66748649
66mating behavior (GO:0007617)3.66589274
67embryonic axis specification (GO:0000578)3.66447087
68positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.65280500
69dendritic spine morphogenesis (GO:0060997)3.61872859
70kinetochore organization (GO:0051383)3.61449066
71endoderm formation (GO:0001706)3.60564474
72long-term synaptic potentiation (GO:0060291)3.58895566
73sequestering of extracellular ligand from receptor (GO:0035581)3.58673648
74kidney morphogenesis (GO:0060993)3.55766920
75gamma-aminobutyric acid transport (GO:0015812)3.51876919
76locomotory exploration behavior (GO:0035641)3.51261271
77detection of calcium ion (GO:0005513)3.50329381
78regulation of dopamine metabolic process (GO:0042053)3.49037203
79regulation of catecholamine metabolic process (GO:0042069)3.49037203
80synaptic transmission, dopaminergic (GO:0001963)3.49033522
81postsynaptic membrane organization (GO:0001941)3.48323616
82female mating behavior (GO:0060180)3.48171915
83regulation of synaptic vesicle exocytosis (GO:2000300)3.48102471
84positive regulation of gastrulation (GO:2000543)3.47806849
85lung secretory cell differentiation (GO:0061140)3.47492894
86synaptic vesicle maturation (GO:0016188)3.47391436
87response to phenylpropanoid (GO:0080184)3.45332263
88gastrulation (GO:0007369)3.42866857
89type B pancreatic cell development (GO:0003323)3.41126076
90righting reflex (GO:0060013)3.39302877
91neuronal action potential propagation (GO:0019227)3.37239010
92serotonin receptor signaling pathway (GO:0007210)3.36642847
93innervation (GO:0060384)3.36370408
94microtubule polymerization or depolymerization (GO:0031109)3.35735399
95spinal cord association neuron differentiation (GO:0021527)3.31972852
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31690980
97regulation of synaptic plasticity (GO:0048167)3.30672228
98presynaptic membrane organization (GO:0097090)3.29525321
99mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29514355
100reflex (GO:0060004)3.29353522
101ATP hydrolysis coupled proton transport (GO:0015991)3.28085244
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28085244
103regulation of female receptivity (GO:0045924)3.27118100
104axonemal dynein complex assembly (GO:0070286)3.27109269
105neuron fate specification (GO:0048665)3.26724750
106forelimb morphogenesis (GO:0035136)3.24697056
107dorsal/ventral pattern formation (GO:0009953)3.24197077
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23901680
109behavioral response to cocaine (GO:0048148)3.23453101
110embryonic skeletal system morphogenesis (GO:0048704)3.23328531
111catecholamine transport (GO:0051937)3.21763250
112regulation of dendritic spine morphogenesis (GO:0061001)3.21143969
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20790225
114regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20382375
115regulation of synaptic transmission, glutamatergic (GO:0051966)3.20187372
116regulation of synaptic vesicle transport (GO:1902803)3.19824316
117cerebellar Purkinje cell layer development (GO:0021680)3.19718271
118long-term memory (GO:0007616)3.19378163
119protein localization to chromosome, centromeric region (GO:0071459)3.19187574
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19175727
121positive regulation of cellular response to oxidative stress (GO:1900409)3.18647976
122positive regulation of response to oxidative stress (GO:1902884)3.18647976
123proximal/distal pattern formation (GO:0009954)3.17828718
124regulation of respiratory system process (GO:0044065)3.16684444
125regulation of sarcomere organization (GO:0060297)3.16049502
126fat-soluble vitamin catabolic process (GO:0042363)3.15869450
127vitamin catabolic process (GO:0009111)3.15869450
128positive regulation of membrane potential (GO:0045838)3.15647565
129positive regulation of neurotransmitter transport (GO:0051590)3.11308925
130layer formation in cerebral cortex (GO:0021819)3.08638395
131social behavior (GO:0035176)3.08162987
132intraspecies interaction between organisms (GO:0051703)3.08162987
133regulation of activin receptor signaling pathway (GO:0032925)3.07656813
134neurotransmitter secretion (GO:0007269)3.07386891
135embryonic pattern specification (GO:0009880)3.07200718
136embryonic foregut morphogenesis (GO:0048617)3.06881263
137female gonad development (GO:0008585)3.05625823
138axis specification (GO:0009798)3.04890247
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04828669
140endocardial cushion development (GO:0003197)3.04091385
141Leydig cell differentiation (GO:0033327)3.03793885
142regulation of transforming growth factor beta2 production (GO:0032909)3.03118251
143neurotransmitter-gated ion channel clustering (GO:0072578)3.02890852
144ganglion development (GO:0061548)3.02413408
145cerebellar Purkinje cell differentiation (GO:0021702)3.02310646
146neurotransmitter transport (GO:0006836)3.01972766
147transferrin transport (GO:0033572)3.01964270
148regulation of growth hormone secretion (GO:0060123)3.01787169
149cochlea development (GO:0090102)3.01474684
150dendritic spine organization (GO:0097061)3.01219998
151bone morphogenesis (GO:0060349)3.01016170
152regulation of vesicle fusion (GO:0031338)3.00601461
153genitalia morphogenesis (GO:0035112)3.00297050
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00228618
155kinetochore assembly (GO:0051382)2.98736686
156positive regulation of synapse maturation (GO:0090129)2.98078461
157transmission of nerve impulse (GO:0019226)2.98019287
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.97932336
159attachment of spindle microtubules to kinetochore (GO:0008608)2.97892279
160embryonic forelimb morphogenesis (GO:0035115)2.96369554
161synaptic vesicle transport (GO:0048489)2.96051220
162establishment of synaptic vesicle localization (GO:0097480)2.96051220
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.93802488
164positive regulation of cell cycle checkpoint (GO:1901978)2.90992251
165membrane depolarization (GO:0051899)2.90171364
166glucocorticoid receptor signaling pathway (GO:0042921)2.89663872
167mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89411176
168dendrite development (GO:0016358)2.89251043
169neuromuscular process controlling posture (GO:0050884)2.88778213
170regulation of dendritic spine development (GO:0060998)2.88612441
171positive regulation of dendritic spine development (GO:0060999)2.88539618
172dorsal/ventral axis specification (GO:0009950)2.88170804
173cilium movement (GO:0003341)2.88088592
174centriole replication (GO:0007099)2.85503419
175neuron fate determination (GO:0048664)2.85461591
176serotonin metabolic process (GO:0042428)2.85204544
177skeletal system morphogenesis (GO:0048705)2.83788816
178regulation of translation, ncRNA-mediated (GO:0045974)2.76413750
179negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76413750
180negative regulation of translation, ncRNA-mediated (GO:0040033)2.76413750
181hindlimb morphogenesis (GO:0035137)2.75362688
182indolalkylamine metabolic process (GO:0006586)2.75128949
183mesonephric tubule development (GO:0072164)2.74889395
184protein localization to microtubule (GO:0035372)2.73445513
185positive regulation of oligodendrocyte differentiation (GO:0048714)2.72393242
186cell differentiation in spinal cord (GO:0021515)2.70215158
187peristalsis (GO:0030432)2.69650440
188embryonic organ morphogenesis (GO:0048562)2.68485433
189protein localization to microtubule cytoskeleton (GO:0072698)2.66889958
190mesonephric epithelium development (GO:0072163)2.66322818
191apical protein localization (GO:0045176)2.64516538
192forebrain neuron differentiation (GO:0021879)2.63320876
193nodal signaling pathway (GO:0038092)2.63309150
194anterior/posterior pattern specification (GO:0009952)2.63300502
195male sex determination (GO:0030238)2.63207209
196pericardium development (GO:0060039)2.59134909
197embryonic skeletal system development (GO:0048706)2.55988636
198striatum development (GO:0021756)2.55536402
199spinal cord motor neuron differentiation (GO:0021522)2.55523456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.55618161
2GBX2_23144817_ChIP-Seq_PC3_Human3.81139301
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.43618401
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.43618401
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.43618401
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.33695165
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28273697
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.21429807
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12460906
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.97510538
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72800916
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69969533
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69442013
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67245970
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67245970
16REST_21632747_ChIP-Seq_MESCs_Mouse2.64837316
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.56332610
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55121717
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54068753
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46684615
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.44080802
22SMAD3_21741376_ChIP-Seq_HESCs_Human2.32612463
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32305756
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.30944542
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23961764
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22529319
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.18425331
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17424071
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.13310307
30ZNF274_21170338_ChIP-Seq_K562_Hela2.13083641
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.08865658
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.08063841
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06350537
34TAF15_26573619_Chip-Seq_HEK293_Human1.99605557
35* REST_18959480_ChIP-ChIP_MESCs_Mouse1.99250965
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.98599558
37VDR_22108803_ChIP-Seq_LS180_Human1.97341033
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97180981
39* SMAD4_21741376_ChIP-Seq_HESCs_Human1.89295153
40P300_19829295_ChIP-Seq_ESCs_Human1.86286051
41SMAD4_21799915_ChIP-Seq_A2780_Human1.81728276
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78475865
43AR_21572438_ChIP-Seq_LNCaP_Human1.76031863
44DROSHA_22980978_ChIP-Seq_HELA_Human1.75202777
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70137385
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66118153
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63059900
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62694813
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62580307
50FUS_26573619_Chip-Seq_HEK293_Human1.61757577
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58642110
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54296270
53IGF1R_20145208_ChIP-Seq_DFB_Human1.52046655
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51207103
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50554877
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49326643
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.49171102
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.48336070
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.46494460
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45345919
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43490818
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.41417354
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40774828
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.40736304
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40322315
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38147289
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.36851449
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.36315263
69AR_25329375_ChIP-Seq_VCAP_Human1.35112551
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35101914
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34390233
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.29915458
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.29275785
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28439037
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.27315720
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26955427
77E2F7_22180533_ChIP-Seq_HELA_Human1.25378443
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25266932
79TP53_18474530_ChIP-ChIP_U2OS_Human1.24464585
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23547148
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.23207743
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22109820
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.20589957
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18764417
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17303157
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.15565555
87* TP53_16413492_ChIP-PET_HCT116_Human1.15150131
88TCF4_22108803_ChIP-Seq_LS180_Human1.14683702
89RNF2_27304074_Chip-Seq_NSC_Mouse1.14484244
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13356216
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.13116558
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12843107
93ER_23166858_ChIP-Seq_MCF-7_Human1.12013496
94JUN_21703547_ChIP-Seq_K562_Human1.11842533
95RUNX2_22187159_ChIP-Seq_PCA_Human1.11246680
96BCAT_22108803_ChIP-Seq_LS180_Human1.09775111
97* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08227376
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08214712
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.08149944
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07715630
101* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06704090
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06433489
103AHR_22903824_ChIP-Seq_MCF-7_Human1.05361935
104STAT3_23295773_ChIP-Seq_U87_Human1.05342809
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05212858
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05212858
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.04520360
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04292059
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03985874
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03920069
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.03645759
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03323766
113AR_19668381_ChIP-Seq_PC3_Human1.02470126
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01215271
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.98308515
116TCF4_23295773_ChIP-Seq_U87_Human0.98103103
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.97940247
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97810315
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97653281
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96888659
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96565486
122* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96391942
123* CBP_20019798_ChIP-Seq_JUKART_Human0.96391942
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96293041
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95130062
126EWS_26573619_Chip-Seq_HEK293_Human0.94050996
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92782983
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92619496
129* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90218918
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89173595
131KDM2B_26808549_Chip-Seq_REH_Human0.87450349
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86821273
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85708250
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.84930371
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84509697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry6.05909315
2MP0004859_abnormal_synaptic_plasticity5.74666259
3MP0003880_abnormal_central_pattern5.57456736
4MP0003635_abnormal_synaptic_transmissio4.05254145
5MP0002063_abnormal_learning/memory/cond3.45594787
6MP0009745_abnormal_behavioral_response3.44536251
7MP0002837_dystrophic_cardiac_calcinosis3.27830887
8MP0001440_abnormal_grooming_behavior3.11175246
9MP0002064_seizures3.05839805
10MP0005503_abnormal_tendon_morphology3.04243997
11MP0002572_abnormal_emotion/affect_behav2.90196708
12MP0003119_abnormal_digestive_system2.89168802
13MP0004270_analgesia2.83985379
14MP0001501_abnormal_sleep_pattern2.79150664
15MP0001348_abnormal_lacrimal_gland2.79000405
16MP0002102_abnormal_ear_morphology2.68156971
17MP0002277_abnormal_respiratory_mucosa2.50609638
18MP0002272_abnormal_nervous_system2.49317765
19MP0001968_abnormal_touch/_nociception2.45764339
20MP0001905_abnormal_dopamine_level2.37466645
21MP0001486_abnormal_startle_reflex2.32484901
22MP0003787_abnormal_imprinting2.32153578
23MP0002736_abnormal_nociception_after2.31695184
24MP0006276_abnormal_autonomic_nervous2.29465107
25MP0003878_abnormal_ear_physiology2.19195974
26MP0005377_hearing/vestibular/ear_phenot2.19195974
27MP0000778_abnormal_nervous_system2.17202481
28MP0009046_muscle_twitch2.15943596
29MP0002184_abnormal_innervation2.12964863
30MP0001529_abnormal_vocalization2.11595813
31MP0003329_amyloid_beta_deposits2.03864414
32MP0002932_abnormal_joint_morphology1.95404804
33MP0003122_maternal_imprinting1.92098537
34MP0002735_abnormal_chemical_nociception1.90631967
35MP0002067_abnormal_sensory_capabilities1.90608296
36MP0002653_abnormal_ependyma_morphology1.90244985
37MP0002734_abnormal_mechanical_nocicepti1.89538650
38MP0003385_abnormal_body_wall1.89247500
39MP0003937_abnormal_limbs/digits/tail_de1.83493988
40MP0004133_heterotaxia1.83250075
41MP0005645_abnormal_hypothalamus_physiol1.76532782
42MP0002822_catalepsy1.76095535
43MP0002557_abnormal_social/conspecific_i1.70967761
44MP0002733_abnormal_thermal_nociception1.69653596
45MP0002233_abnormal_nose_morphology1.69291444
46MP0005076_abnormal_cell_differentiation1.67430774
47MP0001984_abnormal_olfaction1.65582634
48MP0005394_taste/olfaction_phenotype1.63351894
49MP0005499_abnormal_olfactory_system1.63351894
50MP0001970_abnormal_pain_threshold1.62714730
51MP0010030_abnormal_orbit_morphology1.61404206
52MP0004924_abnormal_behavior1.60664187
53MP0005386_behavior/neurological_phenoty1.60664187
54MP0004142_abnormal_muscle_tone1.57700396
55MP0002876_abnormal_thyroid_physiology1.57245385
56MP0003879_abnormal_hair_cell1.50281422
57MP0005423_abnormal_somatic_nervous1.48731578
58MP0008995_early_reproductive_senescence1.41397403
59MP0004811_abnormal_neuron_physiology1.40953261
60MP0003283_abnormal_digestive_organ1.40849450
61MP0008057_abnormal_DNA_replication1.40462028
62MP0005187_abnormal_penis_morphology1.40373780
63MP0008789_abnormal_olfactory_epithelium1.38983892
64MP0004147_increased_porphyrin_level1.38446913
65MP0001286_abnormal_eye_development1.37748493
66MP0000049_abnormal_middle_ear1.36217637
67MP0000955_abnormal_spinal_cord1.35356880
68MP0002249_abnormal_larynx_morphology1.35000073
69MP0008569_lethality_at_weaning1.34723200
70MP0002066_abnormal_motor_capabilities/c1.34452849
71MP0002882_abnormal_neuron_morphology1.34318580
72MP0002909_abnormal_adrenal_gland1.32488422
73MP0001502_abnormal_circadian_rhythm1.31533720
74MP0002084_abnormal_developmental_patter1.31073774
75MP0000428_abnormal_craniofacial_morphol1.30960914
76MP0009250_abnormal_appendicular_skeleto1.29462457
77MP0002163_abnormal_gland_morphology1.29458951
78MP0006072_abnormal_retinal_apoptosis1.26496268
79MP0009780_abnormal_chondrocyte_physiolo1.22955874
80MP0002116_abnormal_craniofacial_bone1.22362558
81MP0004484_altered_response_of1.21195180
82MP0000751_myopathy1.19567836
83MP0002111_abnormal_tail_morphology1.18880465
84MP0009053_abnormal_anal_canal1.18593677
85MP0005535_abnormal_body_temperature1.17975394
86MP0000383_abnormal_hair_follicle1.17676081
87MP0003935_abnormal_craniofacial_develop1.16028898
88MP0010234_abnormal_vibrissa_follicle1.15634644
89MP0001188_hyperpigmentation1.15269680
90MP0002109_abnormal_limb_morphology1.15117897
91MP0000432_abnormal_head_morphology1.11026136
92MP0002114_abnormal_axial_skeleton1.09078830
93MP0003942_abnormal_urinary_system1.07238217
94MP0010368_abnormal_lymphatic_system1.07171575
95MP0010094_abnormal_chromosome_stability1.07073197
96MP0004885_abnormal_endolymph1.06874698
97MP0002152_abnormal_brain_morphology1.06116998
98MP0004858_abnormal_nervous_system1.04356441
99MP0003121_genomic_imprinting1.03398459
100MP0003755_abnormal_palate_morphology1.01668226
101MP0003941_abnormal_skin_development1.01272564
102MP0002751_abnormal_autonomic_nervous1.00695650
103MP0005257_abnormal_intraocular_pressure0.98551540
104MP0000604_amyloidosis0.97745406
105MP0008872_abnormal_physiological_respon0.97581267
106MP0003195_calcinosis0.97425282
107MP0006292_abnormal_olfactory_placode0.97329594
108MP0002085_abnormal_embryonic_tissue0.97303900
109MP0005646_abnormal_pituitary_gland0.95490808
110MP0000762_abnormal_tongue_morphology0.95187282
111MP0003943_abnormal_hepatobiliary_system0.94744937
112MP0004215_abnormal_myocardial_fiber0.94622195
113MP0008004_abnormal_stomach_pH0.93612130
114MP0008877_abnormal_DNA_methylation0.92679143
115MP0001672_abnormal_embryogenesis/_devel0.91992019
116MP0005380_embryogenesis_phenotype0.91992019
117MP0002069_abnormal_eating/drinking_beha0.91954843
118MP0008961_abnormal_basal_metabolism0.91732286
119MP0004085_abnormal_heartbeat0.91576403
120MP0000163_abnormal_cartilage_morphology0.89944775
121MP0002697_abnormal_eye_size0.89451968
122MP0009379_abnormal_foot_pigmentation0.89266465
123MP0001963_abnormal_hearing_physiology0.87644010
124MP0002115_abnormal_skeleton_extremities0.87617471
125MP0000372_irregular_coat_pigmentation0.85883810
126MP0005551_abnormal_eye_electrophysiolog0.85858847
127MP0001664_abnormal_digestion0.85389079
128MP0002752_abnormal_somatic_nervous0.85276827
129MP0002108_abnormal_muscle_morphology0.85068651
130MP0005623_abnormal_meninges_morphology0.84827594
131MP0005171_absent_coat_pigmentation0.84168471
132MP0005508_abnormal_skeleton_morphology0.81037860
133MP0000631_abnormal_neuroendocrine_gland0.80532177
134MP0003631_nervous_system_phenotype0.79977525
135MP0002234_abnormal_pharynx_morphology0.78943017
136MP0001485_abnormal_pinna_reflex0.76395337
137MP0003633_abnormal_nervous_system0.75663681
138MP0003123_paternal_imprinting0.75425292
139MP0001293_anophthalmia0.75234692
140MP0004145_abnormal_muscle_electrophysio0.74403669
141MP0008874_decreased_physiological_sensi0.74188427
142MP0004742_abnormal_vestibular_system0.73774983
143MP0002229_neurodegeneration0.72020095
144MP0004043_abnormal_pH_regulation0.70667151
145MP0000026_abnormal_inner_ear0.70374761
146MP0003115_abnormal_respiratory_system0.69042929
147MP0003632_abnormal_nervous_system0.67423978
148MP0003984_embryonic_growth_retardation0.66552009
149MP0005409_darkened_coat_color0.64417090
150MP0003137_abnormal_impulse_conducting0.61461390
151MP0000681_abnormal_thyroid_gland0.60866361
152MP0000013_abnormal_adipose_tissue0.60825210
153MP0003634_abnormal_glial_cell0.59219568
154MP0003075_altered_response_to0.55303151
155MP0001765_abnormal_ion_homeostasis0.54876729
156MP0003861_abnormal_nervous_system0.54391071
157MP0001177_atelectasis0.54228382
158MP0001943_abnormal_respiration0.53587688
159MP0005379_endocrine/exocrine_gland_phen0.48283450

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.65995243
2Visual hallucinations (HP:0002367)6.10304764
3Focal seizures (HP:0007359)5.25128444
4Myokymia (HP:0002411)5.14134749
5Cerebral inclusion bodies (HP:0100314)5.10228103
6Abnormality of the pubic bones (HP:0003172)5.02623870
7Genetic anticipation (HP:0003743)4.97662373
8Atonic seizures (HP:0010819)4.74456708
9Epileptic encephalopathy (HP:0200134)4.47061723
10Abnormality of the ischium (HP:0003174)4.35815895
11Absence seizures (HP:0002121)4.31366324
12Hyperventilation (HP:0002883)4.17059078
13Dialeptic seizures (HP:0011146)4.14853321
14Febrile seizures (HP:0002373)3.99202334
15Acute necrotizing encephalopathy (HP:0006965)3.86560438
16Generalized tonic-clonic seizures (HP:0002069)3.63145320
17Abnormal umbilical cord blood vessels (HP:0011403)3.55530151
18Single umbilical artery (HP:0001195)3.55530151
19Abnormality of the fetal cardiovascular system (HP:0010948)3.55530151
20Amblyopia (HP:0000646)3.53611962
21Midline defect of the nose (HP:0004122)3.49253705
22Volvulus (HP:0002580)3.47595708
23Abnormal mitochondria in muscle tissue (HP:0008316)3.44816876
24Progressive macrocephaly (HP:0004481)3.44099343
25Neurofibrillary tangles (HP:0002185)3.43967492
26Limb dystonia (HP:0002451)3.43682313
27Short middle phalanx of the 5th finger (HP:0004220)3.43603982
28Delusions (HP:0000746)3.41078783
29Cutaneous finger syndactyly (HP:0010554)3.31396123
30Periauricular skin pits (HP:0100277)3.16997586
31Preauricular pit (HP:0004467)3.16997586
32Ectopic kidney (HP:0000086)3.16311654
33Bilateral microphthalmos (HP:0007633)3.10125676
34Abnormal ciliary motility (HP:0012262)3.08979316
35Drooling (HP:0002307)3.07170874
36Excessive salivation (HP:0003781)3.07170874
37Congenital malformation of the right heart (HP:0011723)3.04913076
38Double outlet right ventricle (HP:0001719)3.04913076
39Abnormality of binocular vision (HP:0011514)3.02988760
40Diplopia (HP:0000651)3.02988760
41Hypoplastic ischia (HP:0003175)3.01514342
42Supranuclear gaze palsy (HP:0000605)3.00466141
43Abnormal respiratory motile cilium morphology (HP:0005938)2.99193536
44Abnormal respiratory epithelium morphology (HP:0012253)2.99193536
45Truncal ataxia (HP:0002078)2.98942049
46Acute encephalopathy (HP:0006846)2.98511656
47Anxiety (HP:0000739)2.98440273
48Bifid tongue (HP:0010297)2.98378715
49Bell-shaped thorax (HP:0001591)2.97966495
50Abnormal vertebral ossification (HP:0100569)2.95840150
51Abnormality of abdominal situs (HP:0011620)2.90967395
52Abdominal situs inversus (HP:0003363)2.90967395
53Short humerus (HP:0005792)2.90462205
54Broad-based gait (HP:0002136)2.88138268
55Mitochondrial inheritance (HP:0001427)2.86716664
56Absent radius (HP:0003974)2.84235129
57Cutaneous syndactyly (HP:0012725)2.83168724
58Aplasia/hypoplasia of the humerus (HP:0006507)2.82900963
59Gait imbalance (HP:0002141)2.79319011
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78781694
61Abnormality of the lower motor neuron (HP:0002366)2.72850660
62Absent forearm bone (HP:0003953)2.65183130
63Aplasia involving forearm bones (HP:0009822)2.65183130
64Abnormal hair whorl (HP:0010721)2.63726146
65Chronic bronchitis (HP:0004469)2.61996521
66Progressive cerebellar ataxia (HP:0002073)2.60153535
67Depression (HP:0000716)2.58995311
68Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.57789282
69Epileptiform EEG discharges (HP:0011182)2.57207894
70Dislocated radial head (HP:0003083)2.54125661
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.53868245
72Hypoplastic labia majora (HP:0000059)2.51643471
73Abnormality of the radial head (HP:0003995)2.47869400
74Short middle phalanx of finger (HP:0005819)2.47378390
75Congenital primary aphakia (HP:0007707)2.45866855
76Myotonia (HP:0002486)2.45752656
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.44843462
78Absent/shortened dynein arms (HP:0200106)2.44843462
79Abnormal pancreas size (HP:0012094)2.44394565
80Myelomeningocele (HP:0002475)2.43488937
81Oligodactyly (hands) (HP:0001180)2.43342381
82Polyphagia (HP:0002591)2.41764934
83Abnormal respiratory motile cilium physiology (HP:0012261)2.40234818
84Intestinal atresia (HP:0011100)2.39545670
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39436896
86Pelvic girdle muscle weakness (HP:0003749)2.39208248
87Anal stenosis (HP:0002025)2.39101249
88Tubulointerstitial nephritis (HP:0001970)2.38000608
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.37817130
90Poor eye contact (HP:0000817)2.37494231
91Action tremor (HP:0002345)2.34090410
92Increased CSF lactate (HP:0002490)2.33630010
93EEG with generalized epileptiform discharges (HP:0011198)2.32799227
94Anophthalmia (HP:0000528)2.29498334
95Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.29355697
96Medial flaring of the eyebrow (HP:0010747)2.28661536
97Abnormal eating behavior (HP:0100738)2.27777318
98Nephrogenic diabetes insipidus (HP:0009806)2.27624229
99Dysmetria (HP:0001310)2.27050443
100Long eyelashes (HP:0000527)2.26008232
101Anosmia (HP:0000458)2.25778092
102Aplasia/Hypoplasia of the uvula (HP:0010293)2.25456837
103Abnormality of the hip-girdle musculature (HP:0001445)2.25076788
104Abnormality of the musculature of the pelvis (HP:0001469)2.25076788
105Labial hypoplasia (HP:0000066)2.23335069
106Abnormality of the labia majora (HP:0012881)2.22547321
107Psychosis (HP:0000709)2.22167744
108Gaze-evoked nystagmus (HP:0000640)2.21847436
109Rapidly progressive (HP:0003678)2.21844520
110Fetal akinesia sequence (HP:0001989)2.21009696
111Protruding tongue (HP:0010808)2.19784994
112Abnormality of the aortic arch (HP:0012303)2.18235364
113Transposition of the great arteries (HP:0001669)2.15555551
114Abnormal connection of the cardiac segments (HP:0011545)2.15555551
115Abnormal ventriculo-arterial connection (HP:0011563)2.15555551
116Shawl scrotum (HP:0000049)2.15498302
117Chromsome breakage (HP:0040012)2.15302027
118Impaired vibration sensation in the lower limbs (HP:0002166)2.15128278
119Skin pits (HP:0100276)2.13177559
120Abnormality of salivation (HP:0100755)2.12581088
121Hypoventilation (HP:0002791)2.12236847
122Hypsarrhythmia (HP:0002521)2.11843154
123Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11813180
124Truncal obesity (HP:0001956)2.11398846
125Renal salt wasting (HP:0000127)2.10748214
126Preaxial foot polydactyly (HP:0001841)2.08854599
127Shoulder girdle muscle weakness (HP:0003547)2.08804390
128Inability to walk (HP:0002540)2.08628032
129Abnormality of the umbilical cord (HP:0010881)2.08096114
130Absent speech (HP:0001344)2.07493771
131Optic disc pallor (HP:0000543)2.07420081
132Genital tract atresia (HP:0001827)2.07148791
133Rhinitis (HP:0012384)2.06682893
134Dysautonomia (HP:0002459)2.06590495
135Renal agenesis (HP:0000104)2.06159450
136Dysdiadochokinesis (HP:0002075)2.06129056
137Abnormality of the parietal bone (HP:0002696)2.05745689
138Abnormal social behavior (HP:0012433)2.05065098
139Impaired social interactions (HP:0000735)2.05065098
140Renal hypoplasia (HP:0000089)2.05007717
141Hypoplastic female external genitalia (HP:0012815)2.04951360
142Oligodactyly (HP:0012165)2.02195840
143Abnormality of the labia minora (HP:0012880)2.01967088
144Atresia of the external auditory canal (HP:0000413)2.01038817
145Vaginal atresia (HP:0000148)2.00947692
146Tracheal stenosis (HP:0002777)1.99974312
147Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99430999
148Chin dimple (HP:0010751)1.99181855
149Unsteady gait (HP:0002317)1.99009424
150Hypoplastic scapulae (HP:0000882)1.97753407
151Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97753407
152Agitation (HP:0000713)1.97252868
153Termporal pattern (HP:0011008)1.96881794
154Insidious onset (HP:0003587)1.96881794
155Esophageal atresia (HP:0002032)1.96741653
156Aplasia/Hypoplasia of the tibia (HP:0005772)1.95855263
157Delayed gross motor development (HP:0002194)1.95301270
158Generalized myoclonic seizures (HP:0002123)1.94755015
159Palpebral edema (HP:0100540)1.93676509
160X-linked dominant inheritance (HP:0001423)1.93393870
161Progressive inability to walk (HP:0002505)1.93012816
162Leukodystrophy (HP:0002415)1.92930642
163Bradykinesia (HP:0002067)1.91254963
164Abnormality of the phalanges of the 5th finger (HP:0004213)1.90725543
165Stereotypic behavior (HP:0000733)1.90453916
166Dyskinesia (HP:0100660)1.90226608
167Chronic hepatic failure (HP:0100626)1.90118545
168Narrow nasal bridge (HP:0000446)1.89614937
169Incomplete penetrance (HP:0003829)1.88839708
170Hemiparesis (HP:0001269)1.88446051
171Impaired smooth pursuit (HP:0007772)1.87923836
172Pheochromocytoma (HP:0002666)1.87589848
173Orthostatic hypotension (HP:0001278)1.87401401
174Increased nuchal translucency (HP:0010880)1.87042197
175Cerebral edema (HP:0002181)1.85785062
176Calcaneovalgus deformity (HP:0001848)1.84653313
177Retinal dysplasia (HP:0007973)1.84551339
178Papilledema (HP:0001085)1.84235122
179Hepatocellular necrosis (HP:0001404)1.83740186
180Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.81346009
181Gonadal dysgenesis (HP:0000133)1.80347994
182Ectopic anus (HP:0004397)1.78477428
183Morphological abnormality of the middle ear (HP:0008609)1.78058418
184Abnormality of the parathyroid morphology (HP:0011766)1.76420590
185Duplication of thumb phalanx (HP:0009942)1.75248126
186Hyperactive renin-angiotensin system (HP:0000841)1.74940558
187Absent eyebrow (HP:0002223)1.74878088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.32479354
2NTRK34.14625687
3PLK43.78739536
4MAP3K93.69319843
5ACVR1B3.44744743
6PLK23.37964243
7MKNK23.34974693
8PNCK3.15539967
9INSRR3.05302017
10BMPR1B2.95289136
11MAP3K122.92298604
12CDC72.87241057
13ARAF2.76769211
14RIPK42.71872497
15MAP3K42.63156672
16ERBB42.59581712
17MINK12.48809200
18GRK52.46746239
19MAP2K72.43292020
20BMPR22.38215331
21CASK2.31709715
22FRK2.27558531
23SIK22.24531167
24PBK2.23207207
25GRK62.20005830
26PTK2B2.18268614
27BRSK22.00915069
28MARK11.98190417
29NEK21.97844524
30MAP3K131.92018238
31KSR21.85926214
32FGR1.85362304
33KSR11.83581925
34MAP2K41.83350946
35MKNK11.83083855
36TRIM281.80831299
37WNK31.77792872
38ERBB31.68121516
39NTRK21.65800109
40WEE11.64553600
41NME11.62830128
42BRD41.57950628
43SIK31.47910094
44MST41.43124444
45CAMK2A1.41494885
46DAPK11.41202656
47TTK1.39601062
48EIF2AK21.39479491
49DYRK21.36371460
50CAMK2B1.35522694
51CDK191.33183802
52MAP3K101.32786414
53GRK11.24650749
54DAPK21.24137756
55FES1.23547308
56CDK51.23465864
57PRKCG1.19294187
58TGFBR11.17883331
59TEC1.12694452
60RAF11.12524454
61LATS21.03913543
62MAPK131.03608412
63PAK61.02339626
64CDK121.02317055
65DYRK31.00415259
66GRK70.99188502
67TAF10.97733716
68CHEK20.96882255
69NTRK10.95680112
70CAMK2D0.93267064
71ICK0.90704377
72MELK0.89245571
73BRSK10.89094818
74DYRK1A0.88193895
75SRPK10.85533107
76DYRK1B0.83123502
77CSNK1G20.81254400
78CDK180.80802747
79CDK140.80478948
80CAMK40.80339457
81STK100.79661977
82PLK10.76444864
83OXSR10.75950789
84FER0.75723899
85STK38L0.75606808
86CDK150.74691038
87CAMKK10.73778892
88LATS10.70640023
89PAK30.70585165
90BRAF0.69961567
91CHEK10.69829755
92ADRBK20.69460890
93UHMK10.68099383
94CAMK2G0.67976127
95ERBB20.67761568
96TNIK0.67494773
97MOS0.66174557
98MAPKAPK50.65791650
99ATR0.65612679
100CDK11A0.64921703
101BCR0.64836718
102SIK10.64790718
103PLK30.63129369
104PRKD30.62221617
105RPS6KC10.58938610
106RPS6KL10.58938610
107CAMK10.58913640
108CAMK1G0.58509418
109RPS6KA60.57956100
110MAP3K70.57504685
111MAP3K60.55924423
112MAP4K20.54280737
113ROCK20.54176140
114MTOR0.53604854
115AKT30.53335462
116CAMKK20.53318716
117STK380.52990111
118ADRBK10.51200201
119DMPK0.51017983
120PHKG10.50835495
121PHKG20.50835495
122PRPF4B0.49567864
123CSNK1G30.48526494
124PRKCE0.47896664
125PRKCZ0.47230652
126CDK10.45897030
127MAP3K10.45770476
128MAPK150.45360166
129MAP3K20.44964949
130CDK20.44505059
131TNK20.44244065
132MAPK100.43862880
133CAMK1D0.43734566
134SGK10.43270062
135STK110.42399193
136GSK3B0.42151576
137LRRK20.41452839
138DDR20.41302883
139AURKB0.40591021
140MAP2K10.40139032
141MYLK0.39389203
142ATM0.39179194
143ILK0.38814450
144TYRO30.38609756
145SGK2230.37887124
146SGK4940.37887124
147PKN20.37224595
148PRKAA10.36786240
149RET0.36041642
150SYK0.35640589
151PRKACA0.34881249
152MAPK10.34597201
153FYN0.34205245
154TSSK60.33691033
155CSNK1E0.33023618
156MUSK0.32440469
157CDK30.31216287
158MARK20.30497444
159PRKCA0.30183748
160PRKACB0.28946084
161RPS6KA30.27580576
162PRKCH0.27333488
163STK390.26677669
164PRKCB0.25218274
165CSNK1G10.23421260
166PDPK10.21866462

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.32473846
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09010764
3Protein export_Homo sapiens_hsa030603.02659354
4Basal cell carcinoma_Homo sapiens_hsa052172.97561514
5Collecting duct acid secretion_Homo sapiens_hsa049662.95523808
6Long-term potentiation_Homo sapiens_hsa047202.87685055
7Oxidative phosphorylation_Homo sapiens_hsa001902.83724718
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80845395
9Amphetamine addiction_Homo sapiens_hsa050312.78647502
10Hippo signaling pathway_Homo sapiens_hsa043902.73348276
11Olfactory transduction_Homo sapiens_hsa047402.61066199
12Circadian entrainment_Homo sapiens_hsa047132.55059748
13Glutamatergic synapse_Homo sapiens_hsa047242.43966126
14Hedgehog signaling pathway_Homo sapiens_hsa043402.40769631
15Morphine addiction_Homo sapiens_hsa050322.35936872
16GABAergic synapse_Homo sapiens_hsa047272.32339829
17TGF-beta signaling pathway_Homo sapiens_hsa043502.30100024
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.25556670
19Alzheimers disease_Homo sapiens_hsa050102.20575702
20Dopaminergic synapse_Homo sapiens_hsa047282.19999183
21Parkinsons disease_Homo sapiens_hsa050122.16570271
22Taste transduction_Homo sapiens_hsa047422.14434682
23Salivary secretion_Homo sapiens_hsa049702.06996484
24Serotonergic synapse_Homo sapiens_hsa047262.04234977
25Renin secretion_Homo sapiens_hsa049242.03539064
26Lysine degradation_Homo sapiens_hsa003101.90712810
27Fanconi anemia pathway_Homo sapiens_hsa034601.86238547
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82911375
29Calcium signaling pathway_Homo sapiens_hsa040201.81863983
30Vibrio cholerae infection_Homo sapiens_hsa051101.78814751
31Cardiac muscle contraction_Homo sapiens_hsa042601.75867410
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.75200794
33Gastric acid secretion_Homo sapiens_hsa049711.72562993
34Cocaine addiction_Homo sapiens_hsa050301.70139476
35Tryptophan metabolism_Homo sapiens_hsa003801.63627188
36Insulin secretion_Homo sapiens_hsa049111.62634163
37Cholinergic synapse_Homo sapiens_hsa047251.61339980
38Huntingtons disease_Homo sapiens_hsa050161.59646163
39Cell cycle_Homo sapiens_hsa041101.58412673
40Oxytocin signaling pathway_Homo sapiens_hsa049211.57275026
41Long-term depression_Homo sapiens_hsa047301.53540918
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51544176
43Basal transcription factors_Homo sapiens_hsa030221.48777406
44Non-homologous end-joining_Homo sapiens_hsa034501.41667592
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41126560
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37601333
47Gap junction_Homo sapiens_hsa045401.31796732
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31363398
49GnRH signaling pathway_Homo sapiens_hsa049121.27788055
50mRNA surveillance pathway_Homo sapiens_hsa030151.26537061
51Base excision repair_Homo sapiens_hsa034101.23378696
52Sphingolipid metabolism_Homo sapiens_hsa006001.23159471
53Phototransduction_Homo sapiens_hsa047441.22896616
54Axon guidance_Homo sapiens_hsa043601.18369378
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18239523
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17834887
57Mismatch repair_Homo sapiens_hsa034301.15057713
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12708878
59cAMP signaling pathway_Homo sapiens_hsa040241.12142129
60RNA transport_Homo sapiens_hsa030131.08336084
61Estrogen signaling pathway_Homo sapiens_hsa049151.05011401
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02756538
63Melanogenesis_Homo sapiens_hsa049161.01377367
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99224583
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99021020
66Proteoglycans in cancer_Homo sapiens_hsa052050.94619598
67MicroRNAs in cancer_Homo sapiens_hsa052060.94333859
68Circadian rhythm_Homo sapiens_hsa047100.93059363
69Butanoate metabolism_Homo sapiens_hsa006500.86539241
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.85235352
71Glioma_Homo sapiens_hsa052140.82508441
72Homologous recombination_Homo sapiens_hsa034400.82414168
73Protein digestion and absorption_Homo sapiens_hsa049740.81895943
74RNA degradation_Homo sapiens_hsa030180.81228050
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79755184
76Thyroid hormone synthesis_Homo sapiens_hsa049180.79629743
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79118278
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78671975
79Spliceosome_Homo sapiens_hsa030400.78464613
80Rheumatoid arthritis_Homo sapiens_hsa053230.77448594
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.77136889
82Propanoate metabolism_Homo sapiens_hsa006400.76875172
83Histidine metabolism_Homo sapiens_hsa003400.76764646
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75557863
85Tight junction_Homo sapiens_hsa045300.72477502
86Oocyte meiosis_Homo sapiens_hsa041140.72111506
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68790141
88Nucleotide excision repair_Homo sapiens_hsa034200.68424313
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68284305
90Pancreatic secretion_Homo sapiens_hsa049720.68007855
91DNA replication_Homo sapiens_hsa030300.67179808
92Glucagon signaling pathway_Homo sapiens_hsa049220.64707807
93ErbB signaling pathway_Homo sapiens_hsa040120.63660205
94Notch signaling pathway_Homo sapiens_hsa043300.63470515
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62463399
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62117291
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61660260
98Pathways in cancer_Homo sapiens_hsa052000.60528021
99African trypanosomiasis_Homo sapiens_hsa051430.60406800
100Type II diabetes mellitus_Homo sapiens_hsa049300.60393906
101Dilated cardiomyopathy_Homo sapiens_hsa054140.59507961
102Prion diseases_Homo sapiens_hsa050200.59499671
103Chemical carcinogenesis_Homo sapiens_hsa052040.57785728
104Adherens junction_Homo sapiens_hsa045200.54761896
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54560634
106Dorso-ventral axis formation_Homo sapiens_hsa043200.53275939
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52932657
108Retinol metabolism_Homo sapiens_hsa008300.52213117
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50013907
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49699108
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49518075
112Alcoholism_Homo sapiens_hsa050340.48619809
113Steroid biosynthesis_Homo sapiens_hsa001000.48262644
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47409404
115Choline metabolism in cancer_Homo sapiens_hsa052310.47046952
116VEGF signaling pathway_Homo sapiens_hsa043700.44999679
117Ras signaling pathway_Homo sapiens_hsa040140.44271549
118MAPK signaling pathway_Homo sapiens_hsa040100.42003012
119p53 signaling pathway_Homo sapiens_hsa041150.41489445
120Phagosome_Homo sapiens_hsa041450.40148970
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.39912970
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39023822
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39021538
124Selenocompound metabolism_Homo sapiens_hsa004500.37395164
125HTLV-I infection_Homo sapiens_hsa051660.37107143
126Wnt signaling pathway_Homo sapiens_hsa043100.34838923
127Rap1 signaling pathway_Homo sapiens_hsa040150.34575846
128Linoleic acid metabolism_Homo sapiens_hsa005910.31665747
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30461957
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29015536
131Renal cell carcinoma_Homo sapiens_hsa052110.28605153
132Bile secretion_Homo sapiens_hsa049760.24679899
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.23698576
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23059810
135Pyruvate metabolism_Homo sapiens_hsa006200.22114093
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19445486
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18675196
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.17144955
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16476460
140Mineral absorption_Homo sapiens_hsa049780.15181750
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14960028
142Inositol phosphate metabolism_Homo sapiens_hsa005620.12963856
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11853459
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11100460
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10259594
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09550162
147Type I diabetes mellitus_Homo sapiens_hsa049400.09434175
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05796149
149Colorectal cancer_Homo sapiens_hsa052100.05158566
150Tuberculosis_Homo sapiens_hsa051520.04119337

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