ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.10267672
2	ribosome assembly (GO:0042255)	5.07838425
3	ATP synthesis coupled proton transport (GO:0015986)	4.65525183
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.65525183
5	chaperone-mediated protein transport (GO:0072321)	4.59271271
6	proteasome assembly (GO:0043248)	4.40597204
7	establishment of integrated proviral latency (GO:0075713)	4.33198694
8	mitotic metaphase plate congression (GO:0007080)	4.08896677
9	L-phenylalanine metabolic process (GO:0006558)	4.03465131
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.03465131
11	respiratory electron transport chain (GO:0022904)	4.00902443
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.98161101
13	pseudouridine synthesis (GO:0001522)	3.94087446
14	electron transport chain (GO:0022900)	3.90306531
15	ribosome biogenesis (GO:0042254)	3.84510580
16	DNA deamination (GO:0045006)	3.84282296
17	glycine metabolic process (GO:0006544)	3.83706203
18	aldehyde catabolic process (GO:0046185)	3.82334643
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.82149288
20	L-phenylalanine catabolic process (GO:0006559)	3.82149288
21	cullin deneddylation (GO:0010388)	3.78820777
22	* protein targeting to mitochondrion (GO:0006626)	3.74028324
23	oxidative phosphorylation (GO:0006119)	3.73595828
24	serine family amino acid biosynthetic process (GO:0009070)	3.71075705
25	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.69420482
26	establishment of viral latency (GO:0019043)	3.66902355
27	rRNA processing (GO:0006364)	3.64732881
28	regulation of cellular amino acid metabolic process (GO:0006521)	3.60639353
29	DNA strand elongation involved in DNA replication (GO:0006271)	3.60191356
30	telomere maintenance via semi-conservative replication (GO:0032201)	3.59659014
31	protein deneddylation (GO:0000338)	3.58769513
32	regulation of ligase activity (GO:0051340)	3.58438355
33	maturation of 5.8S rRNA (GO:0000460)	3.58033268
34	glyoxylate metabolic process (GO:0046487)	3.56762450
35	purine nucleobase biosynthetic process (GO:0009113)	3.56568881
36	spliceosomal snRNP assembly (GO:0000387)	3.54895026
37	DNA strand elongation (GO:0022616)	3.51966595
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.51960448
39	L-methionine salvage (GO:0071267)	3.47080545
40	L-methionine biosynthetic process (GO:0071265)	3.47080545
41	amino acid salvage (GO:0043102)	3.47080545
42	rRNA metabolic process (GO:0016072)	3.46655928
43	* protein localization to mitochondrion (GO:0070585)	3.44221914
44	aromatic amino acid family catabolic process (GO:0009074)	3.44166691
45	cysteine metabolic process (GO:0006534)	3.42738512
46	serine family amino acid metabolic process (GO:0009069)	3.42190448
47	nucleobase biosynthetic process (GO:0046112)	3.41828863
48	serine family amino acid catabolic process (GO:0009071)	3.39680897
49	* establishment of protein localization to mitochondrion (GO:0072655)	3.37508554
50	metaphase plate congression (GO:0051310)	3.36207493
51	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.33932901
52	transcription from mitochondrial promoter (GO:0006390)	3.33517541
53	L-serine metabolic process (GO:0006563)	3.31566921
54	regulation of translational termination (GO:0006449)	3.31400493
55	rRNA methylation (GO:0031167)	3.29169526
56	mitochondrial RNA metabolic process (GO:0000959)	3.25423875
57	IMP biosynthetic process (GO:0006188)	3.25004612
58	7-methylguanosine mRNA capping (GO:0006370)	3.24817325
59	DNA replication checkpoint (GO:0000076)	3.24246920
60	negative regulation of protein ubiquitination (GO:0031397)	3.23925163
61	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.23497835
62	CENP-A containing nucleosome assembly (GO:0034080)	3.22925316
63	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.22445515
64	G1/S transition of mitotic cell cycle (GO:0000082)	3.20849139
65	cell cycle G1/S phase transition (GO:0044843)	3.20849139
66	branched-chain amino acid catabolic process (GO:0009083)	3.20540580
67	lysine metabolic process (GO:0006553)	3.20434977
68	lysine catabolic process (GO:0006554)	3.20434977
69	protein maturation by protein folding (GO:0022417)	3.20207776
70	regulation of mitochondrial translation (GO:0070129)	3.20078349
71	tricarboxylic acid cycle (GO:0006099)	3.17769074
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.17240186
73	folic acid metabolic process (GO:0046655)	3.17030750
74	negative regulation of ligase activity (GO:0051352)	3.16839784
75	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.16839784
76	ribosomal small subunit assembly (GO:0000028)	3.16672381
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16610570
78	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.15946234
79	transcription-coupled nucleotide-excision repair (GO:0006283)	3.15709402
80	7-methylguanosine RNA capping (GO:0009452)	3.14564547
81	RNA capping (GO:0036260)	3.14564547
82	formation of translation preinitiation complex (GO:0001731)	3.14126775
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13591245
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13591245
85	NADH dehydrogenase complex assembly (GO:0010257)	3.13591245
86	indole-containing compound catabolic process (GO:0042436)	3.11853105
87	indolalkylamine catabolic process (GO:0046218)	3.11853105
88	tryptophan catabolic process (GO:0006569)	3.11853105
89	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.10761186
90	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.10761186
91	viral mRNA export from host cell nucleus (GO:0046784)	3.10103361
92	telomere maintenance via recombination (GO:0000722)	3.09459667
93	NADH metabolic process (GO:0006734)	3.09399300
94	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.08916878
95	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.08916878
96	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.08916878
97	rRNA modification (GO:0000154)	3.08373540
98	protein localization to kinetochore (GO:0034501)	3.08245515
99	ribosomal small subunit biogenesis (GO:0042274)	3.08194986
100	transcription from RNA polymerase I promoter (GO:0006360)	3.07963132
101	chromatin remodeling at centromere (GO:0031055)	3.07948377
102	positive regulation of cell cycle arrest (GO:0071158)	3.06097598
103	negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	3.05343840
104	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.04880775
105	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.03494839
106	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.03440721
107	ribosomal large subunit biogenesis (GO:0042273)	3.02462061
108	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.02330207
109	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.02330207
110	tryptophan metabolic process (GO:0006568)	3.01988177
111	kynurenine metabolic process (GO:0070189)	3.01897853
112	DNA damage response, detection of DNA damage (GO:0042769)	3.01133734
113	termination of RNA polymerase I transcription (GO:0006363)	3.00971912
114	protein localization to chromosome, centromeric region (GO:0071459)	2.99779464
115	termination of RNA polymerase III transcription (GO:0006386)	2.98954213
116	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.98954213
117	cellular ketone body metabolic process (GO:0046950)	2.98004075
118	tRNA methylation (GO:0030488)	2.97772766
119	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.97763766
120	sulfur amino acid biosynthetic process (GO:0000097)	2.97538052
121	metallo-sulfur cluster assembly (GO:0031163)	2.96794939
122	iron-sulfur cluster assembly (GO:0016226)	2.96794939
123	mitotic sister chromatid segregation (GO:0000070)	2.96637431
124	histone mRNA metabolic process (GO:0008334)	2.96479893
125	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.94619325
126	viral transcription (GO:0019083)	2.94399458
127	DNA catabolic process, exonucleolytic (GO:0000738)	2.94267539
128	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.93795355
129	translation (GO:0006412)	2.91039201
130	maturation of SSU-rRNA (GO:0030490)	2.89545026
131	ubiquinone biosynthetic process (GO:0006744)	2.87901833
132	quinone biosynthetic process (GO:1901663)	2.87901833
133	aromatic amino acid family metabolic process (GO:0009072)	2.87522364
134	sulfur amino acid catabolic process (GO:0000098)	2.86416291
135	translational termination (GO:0006415)	2.85281410
136	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.84543531
137	positive regulation of ligase activity (GO:0051351)	2.84309840
138	protein complex biogenesis (GO:0070271)	2.84059432
139	ribonucleoprotein complex biogenesis (GO:0022613)	2.83830391
140	pteridine-containing compound biosynthetic process (GO:0042559)	2.80399884
141	folic acid-containing compound biosynthetic process (GO:0009396)	2.80289364
142	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79656498
143	bile acid biosynthetic process (GO:0006699)	2.79317247
144	methionine metabolic process (GO:0006555)	2.78515788
145	amino-acid betaine metabolic process (GO:0006577)	2.76640238
146	cellular component biogenesis (GO:0044085)	2.74680216
147	alpha-amino acid catabolic process (GO:1901606)	2.73895486
148	regulation of cellular amine metabolic process (GO:0033238)	2.71976166
149	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.71805361
150	branched-chain amino acid metabolic process (GO:0009081)	2.71659526
151	nucleobase-containing small molecule interconversion (GO:0015949)	2.69777588

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.41980063
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.12762416
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.99948793
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.70693039
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.69378264
6	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.59780153
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.53579529
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.42353285
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.35412370
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.35370888
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.28761207
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.16451627
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.89986294
14	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.88828668
15	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.84855592
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.60714356
17	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.54017172
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.52592334
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.51106269
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50723820
21	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.42742235
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37432533
23	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.36317726
24	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.35988299
25	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.30627694
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30482055
27	VDR_23849224_ChIP-Seq_CD4+_Human	2.23012649
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.21446345
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.19381696
30	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.14883008
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.10384356
32	* XRN2_22483619_ChIP-Seq_HELA_Human	2.07545273
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.02361236
34	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.93119400
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.91541737
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91249461
37	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88372393
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.87915406
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.86772611
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.77446007
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.75316458
42	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74996049
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.71790324
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.70398551
45	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.67101946
46	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.63824574
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58880554
48	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.57193351
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.55037137
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53074897
51	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.51778836
52	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.50496856
53	AR_21909140_ChIP-Seq_LNCAP_Human	1.49761779
54	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.48375004
55	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.46770122
56	* ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.41088769
57	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.40550293
58	* NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38117571
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36867344
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.34269164
61	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.33325870
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.30571886
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28202689
64	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.28032554
65	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25204362
66	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.24677967
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.24268798
68	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.20014802
69	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19165264
70	* FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.18410651
71	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.16792085
72	ZNF263_19887448_ChIP-Seq_K562_Human	1.15296465
73	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.14196105
74	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.13207711
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.12869930
76	KDM5A_27292631_Chip-Seq_BREAST_Human	1.12680580
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12088151
78	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11796414
79	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.06959425
80	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.06394907
81	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.05444410
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01618865
83	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.01325648
84	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.00413606
85	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.99572942
86	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.97017158
87	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.96250419
88	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.95650365
89	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.94868634
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.94551502
91	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.93855259
92	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.93479033
93	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.92908810
94	* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.92359550
95	MYC_18940864_ChIP-ChIP_HL60_Human	0.91837605
96	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.91279380
97	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.89137890
98	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88906915
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.87745514
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.87067643
101	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.84050681
102	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.83205552
103	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.80832861
104	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80761405
105	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.78790211
106	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.78450337
107	TFEB_21752829_ChIP-Seq_HELA_Human	0.78445754
108	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.78337549
109	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.78180454
110	* CIITA_25753668_ChIP-Seq_RAJI_Human	0.77187013
111	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.76522576
112	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.76212711
113	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.75940026
114	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.75834206
115	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.73218251
116	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.72433777
117	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.71799621
118	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.70541046
119	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.68717342

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.86128019
2	MP0002139_abnormal_hepatobiliary_system	5.54753137
3	MP0005360_urolithiasis	4.73936676
4	MP0005085_abnormal_gallbladder_physiolo	4.22911587
5	MP0005365_abnormal_bile_salt	3.87483939
6	MP0003950_abnormal_plasma_membrane	3.59712232
7	MP0003693_abnormal_embryo_hatching	3.32531274
8	MP0003186_abnormal_redox_activity	3.21450295
9	MP0008875_abnormal_xenobiotic_pharmacok	3.15389755
10	MP0006036_abnormal_mitochondrial_physio	2.93175210
11	MP0004957_abnormal_blastocyst_morpholog	2.77936471
12	MP0005332_abnormal_amino_acid	2.66648000
13	MP0003195_calcinosis	2.56967361
14	MP0009379_abnormal_foot_pigmentation	2.50328511
15	MP0001764_abnormal_homeostasis	2.29232432
16	MP0009697_abnormal_copulation	2.26033862
17	MP0003646_muscle_fatigue	2.25050220
18	MP0005083_abnormal_biliary_tract	2.18023583
19	MP0010329_abnormal_lipoprotein_level	2.09167133
20	MP0003718_maternal_effect	1.97249678
21	MP0006035_abnormal_mitochondrial_morpho	1.96550770
22	MP0009840_abnormal_foam_cell	1.94732549
23	MP0003941_abnormal_skin_development	1.84105523
24	MP0005319_abnormal_enzyme/_coenzyme	1.75435573
25	MP0004019_abnormal_vitamin_homeostasis	1.65963205
26	MP0004233_abnormal_muscle_weight	1.65838476
27	MP0003252_abnormal_bile_duct	1.63254505
28	MP0002837_dystrophic_cardiac_calcinosis	1.63010099
29	MP0010094_abnormal_chromosome_stability	1.61719344
30	MP0005266_abnormal_metabolism	1.56900360
31	MP0005451_abnormal_body_composition	1.55804147
32	MP0000609_abnormal_liver_physiology	1.55466008
33	MP0003111_abnormal_nucleus_morphology	1.53292843
34	MP0008932_abnormal_embryonic_tissue	1.49235125
35	MP0001666_abnormal_nutrient_absorption	1.47883380
36	MP0003221_abnormal_cardiomyocyte_apopto	1.44867892
37	MP0000313_abnormal_cell_death	1.44838217
38	MP0003077_abnormal_cell_cycle	1.42538162
39	MP0005584_abnormal_enzyme/coenzyme_acti	1.41789643
40	MP0008007_abnormal_cellular_replicative	1.40654197
41	MP0005670_abnormal_white_adipose	1.39340256
42	MP0008058_abnormal_DNA_repair	1.37681776
43	MP0009643_abnormal_urine_homeostasis	1.35408209
44	MP0005376_homeostasis/metabolism_phenot	1.29541017
45	MP0002118_abnormal_lipid_homeostasis	1.27411440
46	MP0002877_abnormal_melanocyte_morpholog	1.25848357
47	MP0005330_cardiomyopathy	1.25522707
48	MP0000372_irregular_coat_pigmentation	1.25509856
49	MP0005636_abnormal_mineral_homeostasis	1.23843616
50	MP0005501_abnormal_skin_physiology	1.23244501
51	MP0003786_premature_aging	1.19524016
52	MP0002332_abnormal_exercise_endurance	1.18138725
53	MP0003011_delayed_dark_adaptation	1.17998822
54	MP0003191_abnormal_cellular_cholesterol	1.17574867
55	MP0002796_impaired_skin_barrier	1.15498977
56	MP0005408_hypopigmentation	1.13503019
57	MP0001881_abnormal_mammary_gland	1.09846606
58	MP0010234_abnormal_vibrissa_follicle	1.08953663
59	MP0002102_abnormal_ear_morphology	1.08580487
60	MP0000598_abnormal_liver_morphology	1.08574911
61	MP0002019_abnormal_tumor_incidence	1.06000983
62	MP0002160_abnormal_reproductive_system	1.05221039
63	MP0005084_abnormal_gallbladder_morpholo	1.04142097
64	MP0002210_abnormal_sex_determination	1.04026811
65	MP0004043_abnormal_pH_regulation	1.03822446
66	MP0008057_abnormal_DNA_replication	1.02590201
67	MP0004084_abnormal_cardiac_muscle	1.02540923
68	MP0010307_abnormal_tumor_latency	1.01550746
69	MP0001929_abnormal_gametogenesis	0.99781296
70	MP0002138_abnormal_hepatobiliary_system	0.99623931
71	MP0001756_abnormal_urination	0.99486117
72	MP0003656_abnormal_erythrocyte_physiolo	0.99052513
73	MP0001661_extended_life_span	0.97214105
74	MP0001730_embryonic_growth_arrest	0.96887431
75	MP0000358_abnormal_cell_content/	0.95965622
76	MP0001853_heart_inflammation	0.94173776
77	MP0002396_abnormal_hematopoietic_system	0.94077117
78	MP0002876_abnormal_thyroid_physiology	0.93834119
79	MP0008260_abnormal_autophagy	0.92965430
80	MP0002132_abnormal_respiratory_system	0.92540458
81	MP0000749_muscle_degeneration	0.89667086
82	MP0000750_abnormal_muscle_regeneration	0.88222626
83	MP0001542_abnormal_bone_strength	0.87199771
84	MP0002085_abnormal_embryonic_tissue	0.84685070
85	MP0002086_abnormal_extraembryonic_tissu	0.84210248
86	MP0002269_muscular_atrophy	0.83958115
87	MP0008469_abnormal_protein_level	0.81098546
88	MP0005395_other_phenotype	0.80520470
89	MP0008995_early_reproductive_senescence	0.79686498
90	MP0002163_abnormal_gland_morphology	0.78463576
91	MP0009763_increased_sensitivity_to	0.77811711
92	MP0005666_abnormal_adipose_tissue	0.77702682
93	MP0004215_abnormal_myocardial_fiber	0.77189007
94	MP0005389_reproductive_system_phenotype	0.76983775
95	MP0002084_abnormal_developmental_patter	0.76276836
96	MP0001216_abnormal_epidermal_layer	0.75492641
97	MP0008789_abnormal_olfactory_epithelium	0.75424377
98	MP0000627_abnormal_mammary_gland	0.73835045
99	MP0000653_abnormal_sex_gland	0.73571057
100	MP0009053_abnormal_anal_canal	0.72874873
101	MP0009672_abnormal_birth_weight	0.72806107
102	MP0005384_cellular_phenotype	0.71829958
103	MP0001145_abnormal_male_reproductive	0.71576080
104	MP0003315_abnormal_perineum_morphology	0.70650423
105	MP0004036_abnormal_muscle_relaxation	0.70055217
106	MP0001727_abnormal_embryo_implantation	0.69073753
107	MP0002060_abnormal_skin_morphology	0.69068535
108	MP0003724_increased_susceptibility_to	0.68251344
109	MP0001919_abnormal_reproductive_system	0.67207873
110	MP0009642_abnormal_blood_homeostasis	0.67014464
111	MP0003868_abnormal_feces_composition	0.67011650
112	MP0005410_abnormal_fertilization	0.66918282
113	MP0002971_abnormal_brown_adipose	0.66232976
114	MP0005165_increased_susceptibility_to	0.66175968
115	MP0003699_abnormal_female_reproductive	0.65800892
116	MP0000762_abnormal_tongue_morphology	0.64840730
117	MP0000490_abnormal_crypts_of	0.63681301
118	MP0009333_abnormal_splenocyte_physiolog	0.63306971
119	MP0003984_embryonic_growth_retardation	0.63100526
120	MP0001697_abnormal_embryo_size	0.62178616
121	MP0003567_abnormal_fetal_cardiomyocyte	0.61856567
122	MP0002088_abnormal_embryonic_growth/wei	0.61846408
123	MP0001873_stomach_inflammation	0.61834268
124	MP0003123_paternal_imprinting	0.61214470
125	MP0001672_abnormal_embryogenesis/_devel	0.60715672
126	MP0005380_embryogenesis_phenotype	0.60715672
127	MP0001544_abnormal_cardiovascular_syste	0.60619967
128	MP0005385_cardiovascular_system_phenoty	0.60619967
129	MP0002080_prenatal_lethality	0.60098014
130	MP0002078_abnormal_glucose_homeostasis	0.59976300
131	MP0010352_gastrointestinal_tract_polyps	0.59846100
132	MP0000747_muscle_weakness	0.59156943
133	MP0008873_increased_physiological_sensi	0.58970803
134	MP0004782_abnormal_surfactant_physiolog	0.57969027
135	MP0005535_abnormal_body_temperature	0.57312761
136	MP0000350_abnormal_cell_proliferation	0.57200458
137	MP0001119_abnormal_female_reproductive	0.55694465
138	MP0000343_altered_response_to	0.54800772
139	MP0004130_abnormal_muscle_cell	0.53898684
140	MP0002970_abnormal_white_adipose	0.53588724
141	MP0010030_abnormal_orbit_morphology	0.53574113
142	MP0010771_integument_phenotype	0.52938740
143	MP0002006_tumorigenesis	0.52381113
144	MP0005621_abnormal_cell_physiology	0.51723618
145	MP0001529_abnormal_vocalization	0.51556117
146	MP0004185_abnormal_adipocyte_glucose	0.51466649
147	MP0009765_abnormal_xenobiotic_induced	0.50392727
148	MP0002972_abnormal_cardiac_muscle	0.50222995

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.67278435
2	Hepatic necrosis (HP:0002605)	4.53431719
3	Acute encephalopathy (HP:0006846)	4.52940468
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.40133184
5	Cerebral edema (HP:0002181)	4.30300158
6	Increased serum pyruvate (HP:0003542)	4.19144345
7	Abnormality of glycolysis (HP:0004366)	4.19144345
8	Mitochondrial inheritance (HP:0001427)	4.16174237
9	Hepatocellular necrosis (HP:0001404)	4.13881430
10	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.06381387
11	Increased CSF lactate (HP:0002490)	4.01559004
12	Hypobetalipoproteinemia (HP:0003563)	3.92027227
13	Hyperglycinemia (HP:0002154)	3.83074238
14	Progressive macrocephaly (HP:0004481)	3.78138681
15	Hyperglycinuria (HP:0003108)	3.67627484
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.55290550
17	Lethargy (HP:0001254)	3.50180401
18	Hyperammonemia (HP:0001987)	3.47305034
19	Abnormality of serine family amino acid metabolism (HP:0010894)	3.46545793
20	Abnormality of glycine metabolism (HP:0010895)	3.46545793
21	Lipid accumulation in hepatocytes (HP:0006561)	3.44564465
22	Dicarboxylic aciduria (HP:0003215)	3.41611278
23	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.41611278
24	Increased serum lactate (HP:0002151)	3.40443609
25	Intrahepatic cholestasis (HP:0001406)	3.37030702
26	Lactic acidosis (HP:0003128)	3.35982609
27	Hypoglycemic coma (HP:0001325)	3.32510886
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.31753419
29	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.31753419
30	Abnormality of fatty-acid metabolism (HP:0004359)	3.30350333
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.25987854
32	Increased hepatocellular lipid droplets (HP:0006565)	3.24601995
33	Aplastic anemia (HP:0001915)	3.22090625
34	Degeneration of anterior horn cells (HP:0002398)	3.11135024
35	Abnormality of the anterior horn cell (HP:0006802)	3.11135024
36	3-Methylglutaconic aciduria (HP:0003535)	3.11092999
37	Type I transferrin isoform profile (HP:0003642)	3.11044362
38	Abnormality of serum amino acid levels (HP:0003112)	3.10676066
39	Nausea (HP:0002018)	3.10460512
40	Rough bone trabeculation (HP:0100670)	3.07818909
41	Sparse eyelashes (HP:0000653)	3.02549403
42	Respiratory failure (HP:0002878)	3.01486395
43	Increased muscle lipid content (HP:0009058)	3.00996316
44	Amniotic constriction ring (HP:0009775)	2.97989022
45	Abnormality of placental membranes (HP:0011409)	2.97989022
46	Increased intramyocellular lipid droplets (HP:0012240)	2.94256236
47	Xanthomatosis (HP:0000991)	2.92025170
48	CNS demyelination (HP:0007305)	2.91886081
49	Progressive muscle weakness (HP:0003323)	2.89768385
50	Prolonged partial thromboplastin time (HP:0003645)	2.89005087
51	Generalized aminoaciduria (HP:0002909)	2.87547936
52	Reduced antithrombin III activity (HP:0001976)	2.85130169
53	Abnormality of pyrimidine metabolism (HP:0004353)	2.85016983
54	Hypolipoproteinemia (HP:0010981)	2.82879524
55	Exercise intolerance (HP:0003546)	2.82489879
56	Renal Fanconi syndrome (HP:0001994)	2.82444325
57	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.79787438
58	Glycosuria (HP:0003076)	2.76202010
59	Abnormality of urine glucose concentration (HP:0011016)	2.76202010
60	Abnormality of methionine metabolism (HP:0010901)	2.71897929
61	Proximal tubulopathy (HP:0000114)	2.70451069
62	Ketosis (HP:0001946)	2.70104958
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.66537728
64	Long foot (HP:0001833)	2.63399361
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.62966534
66	Multiple enchondromatosis (HP:0005701)	2.61643986
67	Abnormality of the preputium (HP:0100587)	2.61534600
68	Chromsome breakage (HP:0040012)	2.60049496
69	Neoplasm of the adrenal gland (HP:0100631)	2.56070553
70	Birth length less than 3rd percentile (HP:0003561)	2.56002150
71	Deep venous thrombosis (HP:0002625)	2.54860878
72	Abnormal protein glycosylation (HP:0012346)	2.53457448
73	Abnormal glycosylation (HP:0012345)	2.53457448
74	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.53457448
75	Abnormal protein N-linked glycosylation (HP:0012347)	2.53457448
76	Vomiting (HP:0002013)	2.51743300
77	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.51268838
78	Hyperlipoproteinemia (HP:0010980)	2.51108484
79	Rhabdomyolysis (HP:0003201)	2.48045076
80	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.46587340
81	Premature ovarian failure (HP:0008209)	2.45707339
82	Metabolic acidosis (HP:0001942)	2.45370012
83	Cerebral hypomyelination (HP:0006808)	2.44422002
84	Abnormal trabecular bone morphology (HP:0100671)	2.38786432
85	Methylmalonic aciduria (HP:0012120)	2.37473392
86	Pancytopenia (HP:0001876)	2.35000765
87	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.33205144
88	Abnormality of alanine metabolism (HP:0010916)	2.33205144
89	Hyperalaninemia (HP:0003348)	2.33205144
90	Breast hypoplasia (HP:0003187)	2.32659914
91	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.30860123
92	Trismus (HP:0000211)	2.29896878
93	Macrocytic anemia (HP:0001972)	2.27768052
94	Ketoacidosis (HP:0001993)	2.26420758
95	Reduced subcutaneous adipose tissue (HP:0003758)	2.25542758
96	Delayed CNS myelination (HP:0002188)	2.25348354
97	Oral leukoplakia (HP:0002745)	2.24201008
98	Testicular atrophy (HP:0000029)	2.24113787
99	Leukodystrophy (HP:0002415)	2.21844718
100	Abnormal gallbladder physiology (HP:0012438)	2.20957101
101	Cholecystitis (HP:0001082)	2.20957101
102	Palpitations (HP:0001962)	2.20444921
103	Meckel diverticulum (HP:0002245)	2.19505288
104	Hypoalphalipoproteinemia (HP:0003233)	2.17647875
105	Respiratory difficulties (HP:0002880)	2.15841131
106	Microvesicular hepatic steatosis (HP:0001414)	2.15107771
107	Exertional dyspnea (HP:0002875)	2.14735435
108	Hyperphosphaturia (HP:0003109)	2.13687697
109	Opisthotonus (HP:0002179)	2.13151608
110	Ragged-red muscle fibers (HP:0003200)	2.12387393
111	Abnormality of nucleobase metabolism (HP:0010932)	2.11829508
112	Fat malabsorption (HP:0002630)	2.11434464
113	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11412600
114	Abnormalities of placenta or umbilical cord (HP:0001194)	2.10076512
115	Abnormality of the ileum (HP:0001549)	2.09985724
116	Megaloblastic anemia (HP:0001889)	2.09910512
117	Reticulocytopenia (HP:0001896)	2.08695158
118	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.06204982
119	Abnormal number of erythroid precursors (HP:0012131)	2.05212920
120	Optic disc pallor (HP:0000543)	2.04864189
121	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.04759853
122	Myoglobinuria (HP:0002913)	2.02413411
123	Hyperbilirubinemia (HP:0002904)	2.01926032
124	Carpal bone hypoplasia (HP:0001498)	2.00119526
125	X-linked dominant inheritance (HP:0001423)	1.98299354
126	Hypokinesia (HP:0002375)	1.96713888
127	Brushfield spots (HP:0001088)	1.96143790
128	Congenital ichthyosiform erythroderma (HP:0007431)	1.96067945
129	Gliosis (HP:0002171)	1.95795778
130	Diastasis recti (HP:0001540)	1.92305217
131	Emotional lability (HP:0000712)	1.92233414
132	Secondary amenorrhea (HP:0000869)	1.90951171
133	Progressive external ophthalmoplegia (HP:0000590)	1.90364775
134	Postnatal microcephaly (HP:0005484)	1.88346593
135	Death in infancy (HP:0001522)	1.84596529
136	Horseshoe kidney (HP:0000085)	1.84314186
137	Abnormality of renal resorption (HP:0011038)	1.80527675
138	Ureteral duplication (HP:0000073)	1.77436834
139	Posterior subcapsular cataract (HP:0007787)	1.75624714
140	Myelodysplasia (HP:0002863)	1.75062993
141	Abnormality of the umbilical cord (HP:0010881)	1.74332362
142	Squamous cell carcinoma (HP:0002860)	1.73861575
143	Abnormality of chromosome stability (HP:0003220)	1.73564337
144	Microretrognathia (HP:0000308)	1.71172789
145	Nemaline bodies (HP:0003798)	1.70559930
146	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.70536663

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.06099132
2	BUB1	4.24399555
3	BCKDK	4.11917574
4	NME2	4.11621415
5	EIF2AK1	4.11543320
6	VRK2	3.47254198
7	WEE1	3.46361143
8	EIF2AK3	2.27363755
9	PBK	2.13170771
10	SRPK1	2.07763590
11	TSSK6	2.01174620
12	NME1	1.97583142
13	PDK3	1.89760189
14	PDK4	1.89760189
15	BRSK2	1.85994750
16	PLK4	1.82195883
17	NEK1	1.76750430
18	TLK1	1.75833872
19	TESK2	1.73414553
20	MYLK	1.67230113
21	STK38L	1.66398121
22	PDK2	1.63400445
23	KDR	1.59049568
24	IRAK3	1.51901134
25	NEK9	1.50186059
26	VRK1	1.48063098
27	TRIM28	1.45795221
28	SCYL2	1.38229023
29	TTK	1.36434565
30	MKNK2	1.31194770
31	ZAK	1.31125568
32	PIM2	1.30979623
33	EPHA2	1.29999460
34	MAP3K11	1.27567234
35	PLK1	1.26344567
36	ABL2	1.24835444
37	OBSCN	1.17797481
38	BRAF	1.14054295
39	TESK1	1.13720589
40	MAP3K3	1.13185336
41	AURKA	1.09562462
42	ARAF	1.08752086
43	PRKG2	1.08389569
44	STK10	1.06699247
45	PLK3	1.01364290
46	CDC7	1.01269918
47	AURKB	0.97739489
48	MST4	0.95972688
49	MKNK1	0.94188029
50	LIMK1	0.93827069
51	ACVR1B	0.93593539
52	BMPR1B	0.89706937
53	AKT3	0.86977778
54	EIF2AK2	0.85280126
55	BRSK1	0.82472004
56	PIK3CG	0.77061367
57	NUAK1	0.75287755
58	CSNK2A1	0.72576606
59	CAMK2G	0.70569020
60	DYRK3	0.68179209
61	DAPK3	0.66826283
62	RPS6KA4	0.64244716
63	CSNK2A2	0.63786736
64	CDK9	0.63784436
65	MAP3K12	0.62247453
66	CDK7	0.60434387
67	MAP2K3	0.59823838
68	CDK8	0.59817515
69	PAK4	0.59616550
70	ERBB4	0.58623202
71	CCNB1	0.58535191
72	NEK2	0.58319535
73	MAP3K8	0.58310017
74	STK24	0.58092338
75	ALK	0.54802610
76	PRKCI	0.54544872
77	RAF1	0.52998849
78	ERBB3	0.52806379
79	DYRK2	0.51520204
80	CHEK2	0.49172186
81	STK4	0.46820171
82	MAPKAPK3	0.46142619
83	AKT2	0.45254114
84	CSNK1G3	0.45231456
85	MAP3K5	0.44992819
86	PINK1	0.44560835
87	FLT3	0.44184730
88	MAP3K9	0.43959014
89	SMG1	0.43532398
90	PIM1	0.42804208
91	ATM	0.41733520
92	ILK	0.41407805
93	CAMK2D	0.41290577
94	TAOK2	0.40326540
95	PLK2	0.40245049
96	CAMK2B	0.38110100
97	MOS	0.37949106
98	CSNK1G1	0.37867937
99	PAK1	0.37258132
100	CLK1	0.36984707
101	MST1R	0.36613789
102	LRRK2	0.34990890
103	STK39	0.34441379
104	RPS6KB2	0.33671621
105	ATR	0.33544828
106	CDK4	0.33468199
107	IRAK1	0.33465819
108	ERN1	0.33162258
109	CSNK1A1L	0.32433198
110	NEK6	0.32229335
111	GRK6	0.32166793
112	SIK3	0.29531144
113	BMPR2	0.29223743
114	LATS2	0.29069841
115	MUSK	0.28967153
116	CSNK1E	0.28407526
117	RPS6KA5	0.27861291
118	IRAK4	0.26853609
119	MAPK4	0.26782613
120	CDK1	0.26295483
121	GRK7	0.25755885
122	MAPK11	0.25318755
123	MAPKAPK5	0.25129323
124	STK3	0.23983946
125	BCR	0.23505030
126	WNK3	0.20389946
127	PIK3CA	0.20380951
128	CHEK1	0.19253208
129	MET	0.16805747
130	DAPK1	0.16599647
131	MARK3	0.16168053
132	TGFBR1	0.16101791

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.43579888
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70495715
3	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.63785990
4	Ribosome_Homo sapiens_hsa03010	2.59329242
5	Parkinsons disease_Homo sapiens_hsa05012	2.41932315
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.35897903
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.15939782
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.14941767
9	Propanoate metabolism_Homo sapiens_hsa00640	2.12911728
10	RNA polymerase_Homo sapiens_hsa03020	2.12010020
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.11826461
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.08375868
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08256777
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.98803581
15	Fatty acid degradation_Homo sapiens_hsa00071	1.91815509
16	DNA replication_Homo sapiens_hsa03030	1.85766921
17	Carbon metabolism_Homo sapiens_hsa01200	1.79793855
18	Huntingtons disease_Homo sapiens_hsa05016	1.78409983
19	Pyruvate metabolism_Homo sapiens_hsa00620	1.73437552
20	One carbon pool by folate_Homo sapiens_hsa00670	1.70152878
21	Folate biosynthesis_Homo sapiens_hsa00790	1.68182323
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67440509
23	Peroxisome_Homo sapiens_hsa04146	1.61507831
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61443654
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.60228426
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.60081385
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.59291885
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.55994494
29	Alzheimers disease_Homo sapiens_hsa05010	1.53525691
30	Mismatch repair_Homo sapiens_hsa03430	1.53244723
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50834342
32	Butanoate metabolism_Homo sapiens_hsa00650	1.49854658
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.46056924
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.45006911
35	Protein export_Homo sapiens_hsa03060	1.43002576
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.41521312
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.41497443
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.40353468
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.39508795
40	Fatty acid elongation_Homo sapiens_hsa00062	1.36501974
41	Arginine biosynthesis_Homo sapiens_hsa00220	1.35434594
42	Sulfur relay system_Homo sapiens_hsa04122	1.33779469
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32080074
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.32031475
45	Fatty acid metabolism_Homo sapiens_hsa01212	1.31478966
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31175861
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.29538592
48	Glutathione metabolism_Homo sapiens_hsa00480	1.24220715
49	Sulfur metabolism_Homo sapiens_hsa00920	1.23683045
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.22179751
51	Phenylalanine metabolism_Homo sapiens_hsa00360	1.19927335
52	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18173107
53	Nucleotide excision repair_Homo sapiens_hsa03420	1.16366409
54	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13516491
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11813606
56	Tyrosine metabolism_Homo sapiens_hsa00350	1.11079632
57	RNA transport_Homo sapiens_hsa03013	1.10234848
58	Pentose phosphate pathway_Homo sapiens_hsa00030	1.07654494
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06376005
60	Spliceosome_Homo sapiens_hsa03040	1.06057257
61	Complement and coagulation cascades_Homo sapiens_hsa04610	1.04616162
62	Homologous recombination_Homo sapiens_hsa03440	1.02522194
63	PPAR signaling pathway_Homo sapiens_hsa03320	1.01112537
64	Histidine metabolism_Homo sapiens_hsa00340	0.96932396
65	Retinol metabolism_Homo sapiens_hsa00830	0.91357165
66	Metabolic pathways_Homo sapiens_hsa01100	0.88414704
67	Base excision repair_Homo sapiens_hsa03410	0.88200954
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88102151
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.88045986
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.87936124
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.83882174
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81754730
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.79991037
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.77767918
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77004395
76	Purine metabolism_Homo sapiens_hsa00230	0.74617274
77	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.73309181
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72383862
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.69806053
80	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.67699973
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.65353986
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.64242150
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.63876269
84	Basal transcription factors_Homo sapiens_hsa03022	0.63221055
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.60002447
86	Oocyte meiosis_Homo sapiens_hsa04114	0.59697856
87	RNA degradation_Homo sapiens_hsa03018	0.58585924
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57009285
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53789101
90	Galactose metabolism_Homo sapiens_hsa00052	0.52755716
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52078723
92	Caffeine metabolism_Homo sapiens_hsa00232	0.46771594
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45184316
94	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.44788186
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.44561744
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43747109
97	Cell cycle_Homo sapiens_hsa04110	0.43413892
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.40093334
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39814347
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.39375868
101	Legionellosis_Homo sapiens_hsa05134	0.38508859
102	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37730632
103	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34222893
104	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31731442
105	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31253400
106	Fanconi anemia pathway_Homo sapiens_hsa03460	0.29972870
107	Linoleic acid metabolism_Homo sapiens_hsa00591	0.25907113
108	Regulation of autophagy_Homo sapiens_hsa04140	0.24451663
109	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24354554
110	Mineral absorption_Homo sapiens_hsa04978	0.22541651
111	Herpes simplex infection_Homo sapiens_hsa05168	0.22094840
112	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.19445732
113	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.18638005
114	p53 signaling pathway_Homo sapiens_hsa04115	0.18348280
115	Shigellosis_Homo sapiens_hsa05131	0.17246547
116	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.14208215
117	Viral carcinogenesis_Homo sapiens_hsa05203	0.13196497
118	Apoptosis_Homo sapiens_hsa04210	0.10748139
119	Circadian rhythm_Homo sapiens_hsa04710	0.07505020
120	HTLV-I infection_Homo sapiens_hsa05166	0.06464886

GRPEL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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