ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of sister chromatid cohesion (GO:0007063)	9.81457297
2	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.68090893
3	eosinophil migration (GO:0072677)	9.66952475
4	regulation of mononuclear cell migration (GO:0071675)	9.45096434
5	branch elongation of an epithelium (GO:0060602)	8.54397743
6	positive regulation of chromosome segregation (GO:0051984)	8.05345270
7	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.98287887
8	fucose catabolic process (GO:0019317)	7.97219122
9	L-fucose metabolic process (GO:0042354)	7.97219122
10	L-fucose catabolic process (GO:0042355)	7.97219122
11	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.78874728
12	vesicle fusion (GO:0006906)	7.67858047
13	ribosomal small subunit assembly (GO:0000028)	7.57975711
14	peptidyl-lysine dimethylation (GO:0018027)	7.55498032
15	coenzyme A biosynthetic process (GO:0015937)	7.35175659
16	autophagic vacuole fusion (GO:0000046)	6.89784246
17	macrophage chemotaxis (GO:0048246)	6.70813746
18	organ growth (GO:0035265)	6.67344157
19	localization within membrane (GO:0051668)	6.61542431
20	axis elongation (GO:0003401)	6.39471392
21	positive regulation of calcium ion import (GO:0090280)	5.97469221
22	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.96240275
23	regulation of beta-amyloid formation (GO:1902003)	5.93586384
24	establishment of mitotic spindle orientation (GO:0000132)	5.90666626
25	negative regulation of GTPase activity (GO:0034260)	5.86034921
26	negative regulation of GTP catabolic process (GO:0033125)	5.86034921
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.72231939
28	organelle membrane fusion (GO:0090174)	5.59550561
29	monocyte chemotaxis (GO:0002548)	5.56094149
30	protein import into peroxisome matrix (GO:0016558)	5.50684820
31	non-recombinational repair (GO:0000726)	5.41712173
32	double-strand break repair via nonhomologous end joining (GO:0006303)	5.41712173
33	establishment of mitotic spindle localization (GO:0040001)	5.22325995
34	establishment of spindle orientation (GO:0051294)	5.12791925
35	3-UTR-mediated mRNA stabilization (GO:0070935)	5.11717310
36	negative regulation of circadian rhythm (GO:0042754)	4.97496172
37	acrosome assembly (GO:0001675)	4.96437106
38	histone H3-K9 methylation (GO:0051567)	4.85699785
39	positive chemotaxis (GO:0050918)	4.75231248
40	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.74917722
41	seminiferous tubule development (GO:0072520)	4.71150199
42	organelle fusion (GO:0048284)	4.66937695
43	pantothenate metabolic process (GO:0015939)	4.65626436
44	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.62313632
45	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.61903807
46	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.61903807
47	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.61903807
48	oxidative demethylation (GO:0070989)	4.58982247
49	fucose metabolic process (GO:0006004)	4.54554892
50	regulation of stem cell maintenance (GO:2000036)	4.52863251
51	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.45549262
52	regulation of autophagic vacuole assembly (GO:2000785)	4.34504737
53	protein targeting to lysosome (GO:0006622)	4.26458399
54	establishment of protein localization to vacuole (GO:0072666)	4.26458399
55	protein targeting to vacuole (GO:0006623)	4.26458399
56	coenzyme A metabolic process (GO:0015936)	4.26191657
57	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.23475708
58	fucosylation (GO:0036065)	4.20936010
59	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.07555906
60	histone H3-K9 modification (GO:0061647)	4.06572657
61	membrane budding (GO:0006900)	4.03954386
62	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.03712155
63	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	4.01748073
64	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.97293166
65	negative regulation of nucleotide catabolic process (GO:0030812)	3.91678725
66	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.86482263
67	single-organism membrane fusion (GO:0044801)	3.85666513
68	regulation of cellular amide metabolic process (GO:0034248)	3.82828204
69	negative regulation of nucleoside metabolic process (GO:0045978)	3.76460309
70	establishment of spindle localization (GO:0051293)	3.76138392
71	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.68632646
72	regulation of vacuole organization (GO:0044088)	3.65695481
73	regulation of calcium ion import (GO:0090279)	3.64085438
74	vesicle targeting (GO:0006903)	3.60120515
75	protein localization to peroxisome (GO:0072662)	3.58773703
76	protein targeting to peroxisome (GO:0006625)	3.58773703
77	establishment of protein localization to peroxisome (GO:0072663)	3.58773703
78	negative regulation of macroautophagy (GO:0016242)	3.58333228
79	sodium-independent organic anion transport (GO:0043252)	3.55914931
80	DNA integration (GO:0015074)	3.54841444
81	ER to Golgi vesicle-mediated transport (GO:0006888)	3.51335998
82	imidazole-containing compound metabolic process (GO:0052803)	3.50516111
83	Golgi transport vesicle coating (GO:0048200)	3.46192470
84	COPI coating of Golgi vesicle (GO:0048205)	3.46192470
85	negative regulation of dendrite morphogenesis (GO:0050774)	3.44378987
86	iron-sulfur cluster assembly (GO:0016226)	3.41180525
87	metallo-sulfur cluster assembly (GO:0031163)	3.41180525
88	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.37406291
89	telomere maintenance via recombination (GO:0000722)	3.35216395
90	peroxisomal transport (GO:0043574)	3.35209733
91	labyrinthine layer development (GO:0060711)	3.34269571
92	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31667842
93	prenylation (GO:0097354)	12.8534949
94	protein prenylation (GO:0018342)	12.8534949
95	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.3851258
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.3851258
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.3851258
98	negative regulation of Ras GTPase activity (GO:0034261)	12.3152120
99	eosinophil chemotaxis (GO:0048245)	10.6920316
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.2913239

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.39139937
2	VDR_22108803_ChIP-Seq_LS180_Human	5.97715534
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.68465355
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.52230023
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.35973967
6	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.84408520
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.84405797
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.75611657
9	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.69781570
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.57574520
11	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.53383816
12	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.42178362
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22689774
14	GATA1_22025678_ChIP-Seq_K562_Human	11.7795624
15	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.89156144
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.81339880
17	RXR_22108803_ChIP-Seq_LS180_Human	1.78171173
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75414062
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.75414062
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.68443288
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.60601233
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.60117796
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.60117796
24	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.60117796
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.59582860
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48310874
27	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.44987406
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.34594052
29	TP53_16413492_ChIP-PET_HCT116_Human	1.33526226
30	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.32942916
31	GATA3_26560356_Chip-Seq_TH1_Human	1.28026076
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27132103
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26110496
34	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.19820992
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16037526
36	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15908505
37	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.15638538
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11284125
39	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.11204349
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.06244282
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01265186
42	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.99537143
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.99246180
44	CTCF_21964334_Chip-Seq_Bcells_Human	0.98200001
45	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.97048342
46	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.94949190
47	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.91093271
48	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91035801
49	RUNX_20019798_ChIP-Seq_JUKART_Human	0.89866754
50	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.86314925
51	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.85941133
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.83656922
53	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.81391193
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.81144748
55	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.79961536
56	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.79249951
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.78929953
58	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.76601771
59	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.76382993
60	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.75429944
61	GATA1_19941826_ChIP-Seq_K562_Human	0.75033690
62	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.71767864
63	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.71371186
64	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.68797503
65	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.68736047
66	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.68594461
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.68537539
68	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.68486195
69	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.67569029
70	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.66894787
71	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.65671550
72	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.65174672
73	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.62730178
74	TP53_22573176_ChIP-Seq_HFKS_Human	0.62661736
75	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.62475296
76	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.61921473
77	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.61698681
78	STAT1_20625510_ChIP-Seq_HELA_Human	0.61166059
79	ZNF274_21170338_ChIP-Seq_K562_Hela	0.60653844
80	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.59930352
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.59528525
82	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.57645296
83	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.56276425
84	FUS_26573619_Chip-Seq_HEK293_Human	0.56194041
85	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.55684929
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.55642549
87	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.54975128
88	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.54917320
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.54888941
90	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.54802680
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.54743571
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.54684600
93	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.54532388
94	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.53647574
95	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.53482876
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.52270097
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.52069910
98	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.49611897
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.49188915
100	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.48614251

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.97323181
2	MP0006082_CNS_inflammation	5.44223389
3	MP0000467_abnormal_esophagus_morphology	3.35130987
4	MP0001664_abnormal_digestion	3.21831239
5	MP0001663_abnormal_digestive_system	3.19742463
6	MP0001919_abnormal_reproductive_system	2.72473799
7	MP0000383_abnormal_hair_follicle	2.58105788
8	MP0003115_abnormal_respiratory_system	2.57859188
9	MP0002751_abnormal_autonomic_nervous	2.56880963
10	MP0005381_digestive/alimentary_phenotyp	2.47639084
11	MP0000566_synostosis	13.1105054
12	MP0010678_abnormal_skin_adnexa	1.79278460
13	MP0005166_decreased_susceptibility_to	1.76768089
14	MP0002876_abnormal_thyroid_physiology	1.75756962
15	MP0001915_intracranial_hemorrhage	1.73531961
16	MP0005389_reproductive_system_phenotype	1.65700521
17	MP0003937_abnormal_limbs/digits/tail_de	1.65285417
18	MP0003453_abnormal_keratinocyte_physiol	1.63887284
19	MP0000534_abnormal_ureter_morphology	1.61032270
20	MP0005397_hematopoietic_system_phenotyp	1.46033554
21	MP0001545_abnormal_hematopoietic_system	1.46033554
22	MP0005076_abnormal_cell_differentiation	1.45114077
23	MP0000428_abnormal_craniofacial_morphol	1.43455016
24	MP0005501_abnormal_skin_physiology	1.24966496
25	MP0001286_abnormal_eye_development	1.10999151
26	MP0000490_abnormal_crypts_of	1.10498463
27	MP0000858_altered_metastatic_potential	1.10159248
28	MP0003763_abnormal_thymus_physiology	1.05176285
29	MP0001293_anophthalmia	1.04776571
30	MP0003329_amyloid_beta_deposits	0.96835043
31	MP0002019_abnormal_tumor_incidence	0.90542609
32	MP0002109_abnormal_limb_morphology	0.86505583
33	MP0001764_abnormal_homeostasis	0.83824254
34	MP0000470_abnormal_stomach_morphology	0.81859052
35	MP0003942_abnormal_urinary_system	0.81189230
36	MP0000026_abnormal_inner_ear	0.79137983
37	MP0001963_abnormal_hearing_physiology	0.78534754
38	MP0002115_abnormal_skeleton_extremities	0.78229259
39	MP0000358_abnormal_cell_content/	0.75138356
40	MP0010155_abnormal_intestine_physiology	0.73538079
41	MP0005197_abnormal_uvea_morphology	0.72702773
42	MP0005508_abnormal_skeleton_morphology	0.70106600
43	MP0000477_abnormal_intestine_morphology	0.67548005
44	MP0005023_abnormal_wound_healing	0.66081820
45	MP0009763_increased_sensitivity_to	0.65223900
46	MP0002405_respiratory_system_inflammati	0.63375125
47	MP0000432_abnormal_head_morphology	0.62622239
48	MP0000604_amyloidosis	0.62465618
49	MP0009672_abnormal_birth_weight	0.56329680
50	MP0002210_abnormal_sex_determination	0.55120969
51	MP0000681_abnormal_thyroid_gland	0.55106608
52	MP0003935_abnormal_craniofacial_develop	0.54745567
53	MP0002184_abnormal_innervation	0.52927230
54	MP0001175_abnormal_lung_morphology	0.52538088
55	MP0000377_abnormal_hair_follicle	0.49713373
56	MP0002113_abnormal_skeleton_development	0.48419410
57	MP0005253_abnormal_eye_physiology	0.45789281
58	MP0002822_catalepsy	0.45190743
59	MP0001986_abnormal_taste_sensitivity	0.43850579
60	MP0008058_abnormal_DNA_repair	0.43631924
61	MP0003448_altered_tumor_morphology	0.39904095
62	MP0000627_abnormal_mammary_gland	0.39820174
63	MP0003638_abnormal_response/metabolism_	0.38378773
64	MP0000163_abnormal_cartilage_morphology	0.37889678
65	MP0008004_abnormal_stomach_pH	0.36559171
66	MP0005391_vision/eye_phenotype	0.36333213
67	MP0005423_abnormal_somatic_nervous	0.35647078
68	MP0002697_abnormal_eye_size	0.34917460
69	MP0003936_abnormal_reproductive_system	0.34632359
70	MP0005025_abnormal_response_to	0.33820478
71	MP0010771_integument_phenotype	0.32071139
72	MP0002752_abnormal_somatic_nervous	0.31562487
73	MP0002136_abnormal_kidney_physiology	0.31203610
74	MP0000350_abnormal_cell_proliferation	0.30699725
75	MP0002168_other_aberrant_phenotype	0.26281877
76	MP0002735_abnormal_chemical_nociception	0.25998598
77	MP0005390_skeleton_phenotype	0.25797086
78	MP0004197_abnormal_fetal_growth/weight/	0.25352546
79	MP0003195_calcinosis	0.25195585
80	MP0005503_abnormal_tendon_morphology	0.25188838
81	MP0000049_abnormal_middle_ear	0.24333023
82	MP0005332_abnormal_amino_acid	0.23724773
83	MP0003136_yellow_coat_color	0.22902726
84	MP0002452_abnormal_antigen_presenting	0.21972999
85	MP0005171_absent_coat_pigmentation	0.21754377
86	MP0000372_irregular_coat_pigmentation	0.21433108
87	MP0005275_abnormal_skin_tensile	0.20377911
88	MP0002092_abnormal_eye_morphology	0.20035435
89	MP0009931_abnormal_skin_appearance	0.19684383
90	MP0002234_abnormal_pharynx_morphology	0.19195239
91	MP0002116_abnormal_craniofacial_bone	0.18100814
92	MP0003878_abnormal_ear_physiology	0.17614689
93	MP0005377_hearing/vestibular/ear_phenot	0.17614689
94	MP0002139_abnormal_hepatobiliary_system	0.16601366
95	MP0002081_perinatal_lethality	0.15635748
96	MP0003077_abnormal_cell_cycle	0.15188144
97	MP0001119_abnormal_female_reproductive	0.14228983
98	MP0002161_abnormal_fertility/fecundity	0.13973288
99	MP0005000_abnormal_immune_tolerance	0.13967534
100	MP0000955_abnormal_spinal_cord	0.12846652

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.29850144
2	Long foot (HP:0001833)	9.08180631
3	Abnormality of the renal collecting system (HP:0004742)	8.31815339
4	Large for gestational age (HP:0001520)	7.24958617
5	Acute lymphatic leukemia (HP:0006721)	7.12950567
6	Progressive muscle weakness (HP:0003323)	6.82342698
7	Adactyly (HP:0009776)	6.78567092
8	Hypoplastic pelvis (HP:0008839)	6.34534172
9	Abnormality of fatty-acid metabolism (HP:0004359)	6.17951855
10	Dry hair (HP:0011359)	5.90129160
11	Autoamputation (HP:0001218)	5.77570721
12	Pulmonary artery stenosis (HP:0004415)	5.73602023
13	Ureteral stenosis (HP:0000071)	5.57252130
14	Steatorrhea (HP:0002570)	5.27668867
15	Ureteral obstruction (HP:0006000)	5.18878472
16	Menstrual irregularities (HP:0000858)	5.14318256
17	Brushfield spots (HP:0001088)	5.09994353
18	Ureteral duplication (HP:0000073)	5.07175515
19	Hypoplastic nipples (HP:0002557)	4.89889389
20	Reduced subcutaneous adipose tissue (HP:0003758)	4.63662245
21	Abnormal auditory evoked potentials (HP:0006958)	4.62767130
22	Sudden death (HP:0001699)	4.40073765
23	Abnormal ventriculo-arterial connection (HP:0011563)	4.34730802
24	Transposition of the great arteries (HP:0001669)	4.34730802
25	Abnormal connection of the cardiac segments (HP:0011545)	4.34730802
26	Severe muscular hypotonia (HP:0006829)	4.12994477
27	Fat malabsorption (HP:0002630)	4.09010706
28	Decreased lacrimation (HP:0000633)	4.08326960
29	Increased number of teeth (HP:0011069)	4.02154517
30	Anhidrosis (HP:0000970)	3.85817669
31	Palmoplantar hyperkeratosis (HP:0000972)	3.79458412
32	Broad-based gait (HP:0002136)	3.74166284
33	Palmar hyperkeratosis (HP:0010765)	3.59217877
34	Abnormality of vision evoked potentials (HP:0000649)	3.53790340
35	Generalized amyotrophy (HP:0003700)	3.42459018
36	Polyneuropathy (HP:0001271)	3.28448577
37	Wide intermamillary distance (HP:0006610)	3.27310710
38	Broad nasal tip (HP:0000455)	3.26689700
39	Large hands (HP:0001176)	3.12698328
40	Decreased muscle mass (HP:0003199)	3.12656413
41	Myoglobinuria (HP:0002913)	3.07325605
42	Plantar hyperkeratosis (HP:0007556)	3.06625502
43	Polymicrogyria (HP:0002126)	3.01527776
44	Rhabdomyolysis (HP:0003201)	2.97776264
45	Clubbing of toes (HP:0100760)	2.67195053
46	Epiphyseal stippling (HP:0010655)	2.62293553
47	Flat face (HP:0012368)	2.61437953
48	Chorioretinal coloboma (HP:0000567)	2.59912366
49	Steppage gait (HP:0003376)	2.53997197
50	Hypoplastic iliac wings (HP:0002866)	2.50245978
51	Overfolded helix (HP:0000396)	2.48985981
52	Basal ganglia calcification (HP:0002135)	2.45366683
53	Widely spaced teeth (HP:0000687)	2.38306288
54	Thickened calvaria (HP:0002684)	2.37205154
55	Purpura (HP:0000979)	2.35844043
56	Posterior embryotoxon (HP:0000627)	2.28855696
57	Abnormally folded helix (HP:0008544)	2.24905505
58	Foot dorsiflexor weakness (HP:0009027)	2.21347571
59	Abnormality of the line of Schwalbe (HP:0008048)	2.20665801
60	Anxiety (HP:0000739)	2.15611430
61	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.15094870
62	Absent toe (HP:0010760)	2.11595973
63	Female pseudohermaphroditism (HP:0010458)	2.10431723
64	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.06993252
65	Hammertoe (HP:0001765)	2.03313491
66	Abnormality of the foot musculature (HP:0001436)	2.01191899
67	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	12.2159731
68	Prenatal maternal abnormality (HP:0002686)	1.99573424
69	External ear malformation (HP:0008572)	1.93246994
70	Thickened nuchal skin fold (HP:0000474)	1.92364752
71	Generalized muscle weakness (HP:0003324)	1.89426396
72	Primary adrenal insufficiency (HP:0008207)	1.89087927
73	Abnormal epiphyseal ossification (HP:0010656)	1.84299264
74	Arthrogryposis multiplex congenita (HP:0002804)	1.83054630
75	Stereotypic behavior (HP:0000733)	1.82795369
76	Abnormality of the epiphyses of the hand (HP:0005924)	1.81237640
77	Spastic tetraplegia (HP:0002510)	1.80750119
78	Gangrene (HP:0100758)	1.78711545
79	Congenital onset (HP:0003577)	1.78592511
80	Decreased motor nerve conduction velocity (HP:0003431)	1.74124321
81	Arterial thrombosis (HP:0004420)	1.70208620
82	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.68943015
83	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.62822228
84	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.62432629
85	Short philtrum (HP:0000322)	1.61003387
86	Brachycephaly (HP:0000248)	1.60561409
87	Nail dystrophy (HP:0008404)	1.58623827
88	Depressed nasal ridge (HP:0000457)	1.57460948
89	Lactic acidosis (HP:0003128)	1.57310189
90	Underdeveloped supraorbital ridges (HP:0009891)	1.55668100
91	Scrotal hypoplasia (HP:0000046)	1.50990103
92	Hypoplastic ilia (HP:0000946)	1.42166074
93	Opacification of the corneal stroma (HP:0007759)	1.40388841
94	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.38746730
95	Abnormality of primary teeth (HP:0006481)	1.38258629
96	Retinopathy (HP:0000488)	1.32579739
97	Postnatal microcephaly (HP:0005484)	1.30887601
98	Freckling (HP:0001480)	1.30714494
99	Webbed neck (HP:0000465)	1.30012090
100	Pulmonary embolism (HP:0002204)	1.29744172

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.85056271
2	TAOK2	5.58751028
3	TAOK1	5.51938102
4	MAP3K3	4.13088706
5	MAP2K3	4.01077773
6	MAP3K11	3.96855415
7	JAK3	2.42400856
8	MKNK2	11.5627813
9	ABL2	1.93573139
10	DYRK1A	1.76981665
11	MAP3K5	1.34631213
12	MAP3K1	1.04582030
13	SRPK1	0.96729856
14	CHEK2	0.81934671
15	MAP3K8	0.68461853
16	PRKCQ	0.46441992
17	CSNK1A1	0.19596207
18	ABL1	0.15991083
19	IGF1R	0.13818268
20	INSRR	0.12614090
21	OBSCN	0.10203104
22	PRKCD	0.08793116
23	MAP4K2	0.08253568
24	PLK4	0.08235766
25	MUSK	0.07751563
26	CSNK2A2	0.06437500
27	GRK1	0.06060799
28	GRK7	0.05709211
29	WNK3	0.03660773
30	ADRBK2	0.03589634
31	MAPK15	0.03402388
32	CSNK2A1	0.03256386
33	TXK	0.03122840
34	TIE1	0.03031883
35	AURKA	0.02544895
36	CSNK1E	0.02015458
37	ERBB4	0.00743439
38	CAMK2D	-0.1176671
39	FLT3	-0.1176120
40	FRK	-0.1175276
41	CAMK2B	-0.1170058
42	PRKG1	-0.1168139
43	ERBB2	-0.1162989
44	PRKG2	-0.1143807
45	STK38L	-0.1138339
46	WEE1	-0.1135897
47	MYLK	-0.1118035
48	MAP2K7	-0.1098894
49	PRKCE	-0.1097511
50	BTK	-0.1094804
51	ZAK	-0.1090753
52	TNK2	-0.1084089
53	BCKDK	-0.1049524
54	IKBKE	-0.1036216
55	MAPK14	-0.1016631
56	LYN	-0.1016185
57	AKT3	-0.1016149
58	PIM1	-0.1010837
59	CAMK2A	-0.0975897
60	PRKCG	-0.0973136
61	CAMK2G	-0.0950624
62	CCNB1	-0.0944264
63	SYK	-0.0942901
64	DAPK3	-0.0933978
65	PKN1	-0.0930006
66	BMPR1B	-0.0929476
67	MAP2K6	-0.0924951
68	WNK4	-0.0903753
69	CDK2	-0.0894367
70	ADRBK1	-0.0861863
71	TTN	-0.0814634
72	ITK	-0.0802544
73	NTRK2	-0.0746486
74	EPHB2	-0.0738474
75	TEC	-0.0729600
76	GRK6	-0.0723035
77	PIM2	-0.0682565
78	LMTK2	-0.0647915
79	VRK1	-0.0617412
80	BLK	-0.0588613
81	MATK	-0.0531438
82	EPHA4	-0.0519913
83	DDR2	-0.0470317
84	PINK1	-0.0469123
85	MAPKAPK5	-0.0448822
86	EPHA2	-0.0430749
87	MST1R	-0.0414852
88	KIT	-0.0385964
89	PHKG2	-0.0383598
90	PHKG1	-0.0383598
91	PRKACA	-0.0318396
92	SRC	-0.0316121
93	KDR	-0.0276734
94	PRKCB	-0.0183456
95	STK39	-0.0182458
96	PIK3CG	-0.0177379
97	TLK1	-0.0117200
98	OXSR1	-0.0103493
99	GRK5	-0.0018101
100	PRKCA	-0.0002800

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.64844057
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.31359185
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.26586405
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.06013551
5	Taste transduction_Homo sapiens_hsa04742	3.03289535
6	RNA polymerase_Homo sapiens_hsa03020	3.02329091
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.94250804
8	Fatty acid elongation_Homo sapiens_hsa00062	2.80330226
9	Lysine degradation_Homo sapiens_hsa00310	2.64563146
10	Butanoate metabolism_Homo sapiens_hsa00650	2.41250461
11	beta-Alanine metabolism_Homo sapiens_hsa00410	2.00676833
12	One carbon pool by folate_Homo sapiens_hsa00670	1.86791420
13	Amoebiasis_Homo sapiens_hsa05146	1.83049251
14	Proteasome_Homo sapiens_hsa03050	1.80809913
15	Glycerolipid metabolism_Homo sapiens_hsa00561	1.79294298
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.72245579
17	Propanoate metabolism_Homo sapiens_hsa00640	1.60817608
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.22389633
19	Fatty acid degradation_Homo sapiens_hsa00071	1.18952780
20	Viral myocarditis_Homo sapiens_hsa05416	1.14249530
21	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.11198307
22	Fatty acid metabolism_Homo sapiens_hsa01212	0.99697375
23	Complement and coagulation cascades_Homo sapiens_hsa04610	0.97720187
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87649733
25	Peroxisome_Homo sapiens_hsa04146	0.82453778
26	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79712058
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70144840
28	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.67901354
29	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67502952
30	Caffeine metabolism_Homo sapiens_hsa00232	0.66635539
31	AMPK signaling pathway_Homo sapiens_hsa04152	0.65483722
32	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.60680965
33	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60127677
34	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59397709
35	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.54355311
36	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53763832
37	Asthma_Homo sapiens_hsa05310	0.53636490
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52928213
39	Retinol metabolism_Homo sapiens_hsa00830	0.50974907
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.49852065
41	Olfactory transduction_Homo sapiens_hsa04740	0.48943232
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.48465231
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47677265
44	Salmonella infection_Homo sapiens_hsa05132	0.47248781
45	Choline metabolism in cancer_Homo sapiens_hsa05231	0.46512615
46	Cholinergic synapse_Homo sapiens_hsa04725	0.45548230
47	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.44847269
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42932529
49	Nicotine addiction_Homo sapiens_hsa05033	0.40871883
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39388599
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.39057664
52	GnRH signaling pathway_Homo sapiens_hsa04912	0.38632440
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38045818
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37939904
55	Graft-versus-host disease_Homo sapiens_hsa05332	0.36931190
56	Phototransduction_Homo sapiens_hsa04744	0.35905468
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.35693358
58	Toxoplasmosis_Homo sapiens_hsa05145	0.35343014
59	Allograft rejection_Homo sapiens_hsa05330	0.35113417
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33865907
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.33797581
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33477035
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33354412
64	TNF signaling pathway_Homo sapiens_hsa04668	0.32498253
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.32028409
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31524284
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.30320335
68	RNA transport_Homo sapiens_hsa03013	0.28969673
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28736712
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28153031
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.27644359
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27257781
73	Malaria_Homo sapiens_hsa05144	0.26309021
74	Phagosome_Homo sapiens_hsa04145	0.25553243
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.25447984
76	Purine metabolism_Homo sapiens_hsa00230	0.24314101
77	Phenylalanine metabolism_Homo sapiens_hsa00360	0.20434389
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.18393389
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.18127052
80	Primary immunodeficiency_Homo sapiens_hsa05340	0.17474285
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.17247337
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.17141457
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.17065200
84	ECM-receptor interaction_Homo sapiens_hsa04512	0.16701374
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.16677524
86	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.14407613
87	African trypanosomiasis_Homo sapiens_hsa05143	0.14371804
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.14160687
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.12505792
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.11997686
91	Tuberculosis_Homo sapiens_hsa05152	0.11383814
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.10016314
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.09893759
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.09766172
95	Metabolic pathways_Homo sapiens_hsa01100	0.08971633
96	Bile secretion_Homo sapiens_hsa04976	0.07775751
97	Rap1 signaling pathway_Homo sapiens_hsa04015	0.07534427
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.06808608
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.06650926
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.06476665

GRPEL2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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