GRPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of penile erection (GO:0060405)7.60430388
2vocalization behavior (GO:0071625)6.26941804
3regulation of posttranscriptional gene silencing (GO:0060147)6.18304401
4regulation of gene silencing by miRNA (GO:0060964)6.18304401
5regulation of gene silencing by RNA (GO:0060966)6.18304401
6polyketide metabolic process (GO:0030638)6.09819782
7doxorubicin metabolic process (GO:0044598)6.09819782
8daunorubicin metabolic process (GO:0044597)6.09819782
9anterior/posterior axis specification, embryo (GO:0008595)6.00475357
10pre-miRNA processing (GO:0031054)5.96951042
11prostate gland growth (GO:0060736)5.68275336
12cell migration involved in gastrulation (GO:0042074)5.38200355
13regulation of mesoderm development (GO:2000380)5.34029487
14neurotransmitter-gated ion channel clustering (GO:0072578)5.23400529
15positive regulation of SMAD protein import into nucleus (GO:0060391)5.13707034
16startle response (GO:0001964)5.11480068
17negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.05950428
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.94548111
19regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.77375332
20neuron cell-cell adhesion (GO:0007158)4.64831468
21nodal signaling pathway (GO:0038092)4.61246012
22negative regulation of mast cell activation (GO:0033004)4.56829204
23protein complex localization (GO:0031503)4.52360162
24neurotransmitter biosynthetic process (GO:0042136)4.47186353
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.43655732
26presynaptic membrane assembly (GO:0097105)4.41639683
27regulation of cell fate specification (GO:0042659)4.32758626
28negative regulation of activin receptor signaling pathway (GO:0032926)4.26437003
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.25666342
30establishment of integrated proviral latency (GO:0075713)4.23691597
31regulation of histone H3-K9 methylation (GO:0051570)4.07943316
32protein localization to kinetochore (GO:0034501)4.03276006
33positive regulation of heat generation (GO:0031652)4.01503158
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.01281887
35negative regulation of translation, ncRNA-mediated (GO:0040033)4.01281887
36regulation of translation, ncRNA-mediated (GO:0045974)4.01281887
37succinate metabolic process (GO:0006105)3.95915500
38opioid receptor signaling pathway (GO:0038003)3.92558100
39nuclear pore complex assembly (GO:0051292)3.90963182
40regulation of activin receptor signaling pathway (GO:0032925)3.86894247
41anterior/posterior axis specification (GO:0009948)3.85647762
42branching involved in labyrinthine layer morphogenesis (GO:0060670)3.80960438
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.78432602
44regulation of fever generation (GO:0031620)3.78040372
45aminoglycoside antibiotic metabolic process (GO:0030647)3.77523821
46female gonad development (GO:0008585)3.77408531
47regulation of glutamate receptor signaling pathway (GO:1900449)3.76802595
48positive regulation of cardiac muscle cell proliferation (GO:0060045)3.76715445
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74609729
50postsynaptic membrane organization (GO:0001941)3.72205509
51negative regulation of cell fate specification (GO:0009996)3.70266326
52cerebellar granule cell differentiation (GO:0021707)3.69050696
53transferrin transport (GO:0033572)3.68150706
54auditory receptor cell stereocilium organization (GO:0060088)3.66804437
55positive regulation of synapse assembly (GO:0051965)3.66406333
56regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66321281
57exocrine pancreas development (GO:0031017)3.66260383
58neurotransmitter secretion (GO:0007269)3.64530003
59heterochromatin organization (GO:0070828)3.64484800
60regulation of SMAD protein import into nucleus (GO:0060390)3.62764135
61positive regulation of cellular amide metabolic process (GO:0034250)3.61605215
62negative regulation of dendrite morphogenesis (GO:0050774)3.61489301
63behavioral defense response (GO:0002209)3.58241231
64behavioral fear response (GO:0001662)3.58241231
65paraxial mesoderm development (GO:0048339)3.57650689
66glutamate receptor signaling pathway (GO:0007215)3.57562144
67nuclear pore organization (GO:0006999)3.56505042
68presynaptic membrane organization (GO:0097090)3.56382512
69aggressive behavior (GO:0002118)3.53683127
70DNA replication-dependent nucleosome assembly (GO:0006335)3.52692663
71DNA replication-dependent nucleosome organization (GO:0034723)3.52692663
72somite rostral/caudal axis specification (GO:0032525)3.52472303
73trivalent inorganic cation transport (GO:0072512)3.52195156
74ferric iron transport (GO:0015682)3.52195156
75mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.51444174
76mitotic G2/M transition checkpoint (GO:0044818)3.50835619
77primitive streak formation (GO:0090009)3.48163474
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47928186
79neuron-neuron synaptic transmission (GO:0007270)3.47205270
80phagosome maturation (GO:0090382)3.47075773
81regulation of gastrulation (GO:0010470)3.43396657
82detection of molecule of bacterial origin (GO:0032490)3.43311566
83embryonic axis specification (GO:0000578)3.42614367
84regulation of gene silencing (GO:0060968)3.42082225
85regulation of synapse maturation (GO:0090128)3.41721514
86CENP-A containing nucleosome assembly (GO:0034080)3.41572550
87chromatin remodeling at centromere (GO:0031055)3.40651631
88lysine catabolic process (GO:0006554)3.39831105
89lysine metabolic process (GO:0006553)3.39831105
90response to histamine (GO:0034776)3.39630169
91mitotic metaphase plate congression (GO:0007080)3.36457830
92ionotropic glutamate receptor signaling pathway (GO:0035235)3.36209917
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33128266
94regulation of stem cell maintenance (GO:2000036)3.32737862
95histone exchange (GO:0043486)3.32309246
96negative regulation of androgen receptor signaling pathway (GO:0060766)3.31409429
97cellular response to ammonium ion (GO:0071242)3.28147460
98DNA replication checkpoint (GO:0000076)3.27041511
99negative regulation of cell fate commitment (GO:0010454)3.26642763
100female mating behavior (GO:0060180)3.26072272
101protein localization to chromosome, centromeric region (GO:0071459)3.25549902
102positive regulation of cardiac muscle tissue growth (GO:0055023)3.24190722
103locomotory exploration behavior (GO:0035641)3.23863330
104neurotransmitter metabolic process (GO:0042133)3.18969903
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18853835
106establishment of viral latency (GO:0019043)3.18706367
107serotonin receptor signaling pathway (GO:0007210)3.18573978
108regulation of helicase activity (GO:0051095)3.18471969
109surfactant homeostasis (GO:0043129)3.18431413
110double-strand break repair via nonhomologous end joining (GO:0006303)3.17860617
111non-recombinational repair (GO:0000726)3.17860617
112neuromuscular synaptic transmission (GO:0007274)3.17710353
113gamma-aminobutyric acid signaling pathway (GO:0007214)3.17606237
114negative regulation of dendrite development (GO:2000171)3.17392137
115chemical homeostasis within a tissue (GO:0048875)3.17375616
116DNA unwinding involved in DNA replication (GO:0006268)3.16016722
117embryonic pattern specification (GO:0009880)3.15175076
118regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13621658
119synaptic transmission, glutamatergic (GO:0035249)3.12879458
120mitotic sister chromatid cohesion (GO:0007064)3.12799361
121energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12566374
122ATP hydrolysis coupled proton transport (GO:0015991)3.12566374
123sequestering of extracellular ligand from receptor (GO:0035581)3.12474871
124negative regulation of catecholamine secretion (GO:0033604)3.11879728
125signal transduction involved in regulation of gene expression (GO:0023019)3.11148904
126negative regulation of histone methylation (GO:0031061)3.11080314
127fear response (GO:0042596)3.10178431
128inner ear receptor stereocilium organization (GO:0060122)3.09704916
129regulation of cell fate commitment (GO:0010453)3.09045717
130dorsal/ventral axis specification (GO:0009950)3.07841793
131positive regulation of action potential (GO:0045760)3.04590782
132ATP-dependent chromatin remodeling (GO:0043044)3.03987772
133gastrulation with mouth forming second (GO:0001702)3.03825957
134somatic hypermutation of immunoglobulin genes (GO:0016446)3.03751275
135somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03751275
136regulation of female receptivity (GO:0045924)3.02808908
137gastrulation (GO:0007369)3.01367511
138prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.00234984
139glomerular visceral epithelial cell development (GO:0072015)2.98843574
140regulation of cardioblast differentiation (GO:0051890)2.98436295
141long-term synaptic potentiation (GO:0060291)2.97803916
142positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.96946052
143regulation of heat generation (GO:0031650)2.96121636
144positive regulation of circadian rhythm (GO:0042753)2.95613186
145behavioral response to nicotine (GO:0035095)2.94596579
146DNA replication-independent nucleosome organization (GO:0034724)2.94371378
147DNA replication-independent nucleosome assembly (GO:0006336)2.94371378
148regulation of action potential (GO:0098900)2.92410964
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.92237416
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92237416
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.92237416
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.92237416
153negative regulation of sister chromatid segregation (GO:0033046)2.92237416
154regulation of synaptic vesicle exocytosis (GO:2000300)2.91472985
155regulation of tight junction assembly (GO:2000810)2.90950062
156regulation of cofactor metabolic process (GO:0051193)2.90285962
157regulation of coenzyme metabolic process (GO:0051196)2.90285962
158negative regulation of amine transport (GO:0051953)2.90213704
159negative regulation of chromosome segregation (GO:0051985)2.89941787
160notochord development (GO:0030903)2.89653210
161pore complex assembly (GO:0046931)2.88741849
162metaphase plate congression (GO:0051310)2.88651576
163regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.87426044
164regulation of cardiac muscle cell proliferation (GO:0060043)2.86548612
165regulation of RNA export from nucleus (GO:0046831)2.83745925
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82637218
167embryonic camera-type eye development (GO:0031076)2.82205663
168neurotransmitter transport (GO:0006836)2.81840487
169embryonic foregut morphogenesis (GO:0048617)2.81402921
170regulation of sensory perception (GO:0051931)2.80706011
171regulation of sensory perception of pain (GO:0051930)2.80706011
172mitotic G2 DNA damage checkpoint (GO:0007095)2.80474434
173protein-cofactor linkage (GO:0018065)2.80254695
174positive regulation of cardiac muscle hypertrophy (GO:0010613)2.80018937
175positive regulation of muscle hypertrophy (GO:0014742)2.80018937
176mitotic spindle checkpoint (GO:0071174)2.79201031
177regulation of synapse assembly (GO:0051963)2.79096464
178negative regulation of DNA repair (GO:0045738)2.78499924
179spindle checkpoint (GO:0031577)2.78467433
180regulation of chromatin silencing (GO:0031935)2.78182320
181membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77304264
182digestive tract morphogenesis (GO:0048546)2.75913515
183ncRNA catabolic process (GO:0034661)2.74714735
184sister chromatid segregation (GO:0000819)2.74393516
185transmission of nerve impulse (GO:0019226)2.73773659
186regulation of centriole replication (GO:0046599)2.73363894
187striatum development (GO:0021756)2.73103740
188neuropeptide signaling pathway (GO:0007218)2.71575300
189regulation of dopamine secretion (GO:0014059)2.71397454
190regulation of circadian sleep/wake cycle (GO:0042749)2.70301846
191regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.70301846
192regulation of synaptic transmission, GABAergic (GO:0032228)2.69044339
193negative regulation of synaptic transmission (GO:0050805)2.68967134
194generation of neurons (GO:0048699)2.67721621
195positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66959579
196detection of calcium ion (GO:0005513)2.66912398
197extracellular negative regulation of signal transduction (GO:1900116)2.66866217
198extracellular regulation of signal transduction (GO:1900115)2.66866217
199positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.66631433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70165062
2EZH2_22144423_ChIP-Seq_EOC_Human5.14154733
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.06323984
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.06323984
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.06323984
6GBX2_23144817_ChIP-Seq_PC3_Human4.35402712
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88447991
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.46814988
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29293661
10TAF15_26573619_Chip-Seq_HEK293_Human3.27227093
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20810981
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.02857744
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80803459
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71162804
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.65370242
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57935151
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52897290
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52113692
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46160818
20NANOG_16153702_ChIP-ChIP_HESCs_Human2.44367151
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43297647
22AR_21909140_ChIP-Seq_LNCAP_Human2.42564625
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42118009
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.38894390
25IGF1R_20145208_ChIP-Seq_DFB_Human2.38291503
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.38112563
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.37329551
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35526600
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27771323
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24508926
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.21005861
32MYC_18555785_ChIP-Seq_MESCs_Mouse2.16756812
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16282809
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.13647512
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12373095
36SMAD_19615063_ChIP-ChIP_OVARY_Human2.07471927
37WT1_19549856_ChIP-ChIP_CCG9911_Human2.06131198
38JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03938217
39EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03845899
40RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03845899
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02449420
42* P300_19829295_ChIP-Seq_ESCs_Human2.02050979
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99788891
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98914036
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98105269
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.93653076
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92919574
48REST_21632747_ChIP-Seq_MESCs_Mouse1.92622330
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92175129
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.90786089
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.89632639
52* SMAD3_21741376_ChIP-Seq_HESCs_Human1.87487442
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86904025
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.86863367
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86706597
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84038410
57RNF2_27304074_Chip-Seq_NSC_Mouse1.83737821
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80231707
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79668747
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78715958
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.77875610
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77693920
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77206383
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.76107247
65* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75987745
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75187413
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74999110
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74963037
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.74139319
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72996707
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68560753
72ER_23166858_ChIP-Seq_MCF-7_Human1.68314778
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67962178
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67698998
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.65535587
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.64835282
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63415897
78DROSHA_22980978_ChIP-Seq_HELA_Human1.62889778
79FUS_26573619_Chip-Seq_HEK293_Human1.61184670
80ELK1_19687146_ChIP-ChIP_HELA_Human1.60027605
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59899477
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.57918692
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57792863
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57470001
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57344437
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57254885
87* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56818469
88AR_25329375_ChIP-Seq_VCAP_Human1.54951872
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53928487
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.49313399
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48572620
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48116722
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47907339
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.45436964
95VDR_22108803_ChIP-Seq_LS180_Human1.44197935
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43294228
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40893746
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40176592
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.40127825
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39156382
101EOMES_21245162_ChIP-Seq_HESCs_Human1.38853696
102* SMAD4_21741376_ChIP-Seq_HESCs_Human1.35967436
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35669827
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35084257
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.34105064
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.33879680
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33689830
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33658401
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33608866
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33561068
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33354126
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.33331258
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33004386
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.32818301
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.32235227
116* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31971710
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31279251
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30158392
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27603141
120* RUNX2_22187159_ChIP-Seq_PCA_Human1.27072197
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26813045
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.26764879
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25826494
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25573880
125P53_22387025_ChIP-Seq_ESCs_Mouse1.25306081
126STAT3_23295773_ChIP-Seq_U87_Human1.24391625
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23711699
128TCF4_23295773_ChIP-Seq_U87_Human1.23698727
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.23692710
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22685852
131JUN_21703547_ChIP-Seq_K562_Human1.22354289
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21888296
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21726623
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.20740384
135TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20035837
136NANOG_21062744_ChIP-ChIP_HESCs_Human1.19813616
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.19474924
138POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17705200
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17468263
140KDM2B_26808549_Chip-Seq_REH_Human1.16647364
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.16267514
142MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16256833
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.15251495
144SOX17_20123909_ChIP-Seq_XEN_Mouse1.14704504
145NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14576013
146ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13638426
147POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13568951
148MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13123642
149* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12806276
150GABP_17652178_ChIP-ChIP_JURKAT_Human1.11227995
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10329230
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09121041
153AHR_22903824_ChIP-Seq_MCF-7_Human1.09109461
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08377881
155PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08327806
156FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08269710
157NANOG_16518401_ChIP-PET_MESCs_Mouse1.07308638
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06863484
159CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06759185
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05538212
161P300_18555785_Chip-Seq_ESCs_Mouse1.05403240
162NMYC_18555785_Chip-Seq_ESCs_Mouse1.05232871
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05215468
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04946587
165SOX2_18555785_Chip-Seq_ESCs_Mouse1.04696102
166HTT_18923047_ChIP-ChIP_STHdh_Human1.04245371
167POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04080833
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02962940
169NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02519678
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02153397
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02153397
172CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01984560
173P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00922079
174RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00899208
175EWS_26573619_Chip-Seq_HEK293_Human1.00871263
176* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00053903
177ISL1_27105846_Chip-Seq_CPCs_Mouse0.99908854
178DCP1A_22483619_ChIP-Seq_HELA_Human0.97697023
179NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97424313
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96904965
181HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93402463
182SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92885296
183SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91952639
184SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90468223
185PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89633453
186ESR1_21235772_ChIP-Seq_MCF-7_Human0.89329295
187TTF2_22483619_ChIP-Seq_HELA_Human0.88534957
188EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88359596
189KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87302064
190SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87264663
191FOXP3_21729870_ChIP-Seq_TREG_Human0.86184523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry5.91993308
2MP0002254_reproductive_system_inflammat4.74933458
3MP0003941_abnormal_skin_development3.60023831
4MP0010030_abnormal_orbit_morphology3.39329168
5MP0009745_abnormal_behavioral_response3.28711958
6MP0005646_abnormal_pituitary_gland3.20698786
7MP0002876_abnormal_thyroid_physiology3.19126146
8MP0002735_abnormal_chemical_nociception3.12164406
9MP0001188_hyperpigmentation3.07793341
10MP0003787_abnormal_imprinting3.00124391
11MP0002822_catalepsy2.99313867
12MP0001501_abnormal_sleep_pattern2.95990257
13MP0003693_abnormal_embryo_hatching2.92047873
14MP0009046_muscle_twitch2.87550050
15MP0009780_abnormal_chondrocyte_physiolo2.84112726
16MP0002064_seizures2.82102445
17MP0004957_abnormal_blastocyst_morpholog2.80898215
18MP0003119_abnormal_digestive_system2.80735347
19MP0004133_heterotaxia2.79136207
20MP0004859_abnormal_synaptic_plasticity2.72526045
21MP0008260_abnormal_autophagy2.70939358
22MP0003635_abnormal_synaptic_transmissio2.60291658
23MP0005645_abnormal_hypothalamus_physiol2.53128491
24MP0008932_abnormal_embryonic_tissue2.45298471
25MP0000678_abnormal_parathyroid_gland2.44832785
26MP0003879_abnormal_hair_cell2.44340577
27MP0000537_abnormal_urethra_morphology2.42532718
28MP0004264_abnormal_extraembryonic_tissu2.39372590
29MP0002063_abnormal_learning/memory/cond2.36756665
30MP0002572_abnormal_emotion/affect_behav2.30875027
31MP0009672_abnormal_birth_weight2.29386253
32MP0003880_abnormal_central_pattern2.25599362
33MP0002736_abnormal_nociception_after2.22890986
34MP0006276_abnormal_autonomic_nervous2.20001860
35MP0002272_abnormal_nervous_system2.19188143
36MP0005499_abnormal_olfactory_system2.13633130
37MP0005394_taste/olfaction_phenotype2.13633130
38MP0003937_abnormal_limbs/digits/tail_de2.12275569
39MP0001968_abnormal_touch/_nociception2.11686540
40MP0001986_abnormal_taste_sensitivity2.11547855
41MP0004142_abnormal_muscle_tone2.11018265
42MP0010386_abnormal_urinary_bladder2.05205264
43MP0003183_abnormal_peptide_metabolism2.04898667
44MP0010094_abnormal_chromosome_stability2.03127083
45MP0003122_maternal_imprinting1.99405802
46MP0002084_abnormal_developmental_patter1.96740336
47MP0001672_abnormal_embryogenesis/_devel1.92369997
48MP0005380_embryogenesis_phenotype1.92369997
49MP0008004_abnormal_stomach_pH1.89972590
50MP0003111_abnormal_nucleus_morphology1.87239028
51MP0008057_abnormal_DNA_replication1.87138159
52MP0001293_anophthalmia1.86376734
53MP0001730_embryonic_growth_arrest1.84156884
54MP0003077_abnormal_cell_cycle1.81663838
55MP0002184_abnormal_innervation1.80508596
56MP0005171_absent_coat_pigmentation1.80466785
57MP0002085_abnormal_embryonic_tissue1.79727907
58MP0001486_abnormal_startle_reflex1.78293607
59MP0002277_abnormal_respiratory_mucosa1.71922792
60MP0003984_embryonic_growth_retardation1.68499494
61MP0003567_abnormal_fetal_cardiomyocyte1.67257592
62MP0008058_abnormal_DNA_repair1.65303487
63MP0005423_abnormal_somatic_nervous1.64358269
64MP0002088_abnormal_embryonic_growth/wei1.64228154
65MP0002734_abnormal_mechanical_nocicepti1.63741639
66MP0002067_abnormal_sensory_capabilities1.63238486
67MP0003283_abnormal_digestive_organ1.61083179
68MP0006292_abnormal_olfactory_placode1.60969159
69MP0004272_abnormal_basement_membrane1.60566818
70MP0005647_abnormal_sex_gland1.57639989
71MP0004185_abnormal_adipocyte_glucose1.57248345
72MP0002837_dystrophic_cardiac_calcinosis1.57088164
73MP0003136_yellow_coat_color1.55821488
74MP0000428_abnormal_craniofacial_morphol1.55777405
75MP0001440_abnormal_grooming_behavior1.52560899
76MP0001299_abnormal_eye_distance/1.51902513
77* MP0002557_abnormal_social/conspecific_i1.50001714
78MP0009697_abnormal_copulation1.49507248
79MP0002697_abnormal_eye_size1.47714226
80MP0003718_maternal_effect1.47712154
81MP0001270_distended_abdomen1.46967511
82MP0001286_abnormal_eye_development1.46281047
83MP0009703_decreased_birth_body1.46274524
84MP0002233_abnormal_nose_morphology1.45273448
85MP0003566_abnormal_cell_adhesion1.44638586
86MP0003646_muscle_fatigue1.44359721
87MP0004782_abnormal_surfactant_physiolog1.42683259
88MP0001970_abnormal_pain_threshold1.42080652
89MP0001697_abnormal_embryo_size1.40668409
90MP0010352_gastrointestinal_tract_polyps1.39890091
91MP0002638_abnormal_pupillary_reflex1.37125149
92MP0002111_abnormal_tail_morphology1.31662916
93MP0002733_abnormal_thermal_nociception1.29001998
94MP0002086_abnormal_extraembryonic_tissu1.26171292
95MP0000681_abnormal_thyroid_gland1.26113832
96MP0001542_abnormal_bone_strength1.26011561
97MP0004742_abnormal_vestibular_system1.23645676
98MP0008789_abnormal_olfactory_epithelium1.22553941
99MP0002080_prenatal_lethality1.21383749
100MP0004197_abnormal_fetal_growth/weight/1.20849628
101MP0000350_abnormal_cell_proliferation1.19499761
102MP0000566_synostosis1.16712062
103MP0003315_abnormal_perineum_morphology1.12345315
104MP0006054_spinal_hemorrhage1.11946072
105MP0000432_abnormal_head_morphology1.10191397
106MP0004134_abnormal_chest_morphology1.10137150
107MP0001664_abnormal_digestion1.09213340
108MP0009384_cardiac_valve_regurgitation1.07969141
109MP0003935_abnormal_craniofacial_develop1.07582805
110MP0003861_abnormal_nervous_system1.07089962
111MP0000049_abnormal_middle_ear1.06874063
112MP0003724_increased_susceptibility_to1.06300211
113MP0005377_hearing/vestibular/ear_phenot1.05268928
114MP0003878_abnormal_ear_physiology1.05268928
115MP0001963_abnormal_hearing_physiology1.04185004
116MP0000516_abnormal_urinary_system1.02222144
117MP0005367_renal/urinary_system_phenotyp1.02222144
118MP0002332_abnormal_exercise_endurance1.01271612
119MP0001529_abnormal_vocalization1.01129173
120MP0004924_abnormal_behavior1.00615772
121MP0005386_behavior/neurological_phenoty1.00615772
122MP0003121_genomic_imprinting0.99417786
123MP0002108_abnormal_muscle_morphology0.98884572
124MP0001881_abnormal_mammary_gland0.98860490
125MP0002925_abnormal_cardiovascular_devel0.97956967
126MP0000026_abnormal_inner_ear0.95945443
127MP0002751_abnormal_autonomic_nervous0.94135703
128MP0003938_abnormal_ear_development0.94123871
129MP0008877_abnormal_DNA_methylation0.92976371
130MP0010307_abnormal_tumor_latency0.91363994
131* MP0002066_abnormal_motor_capabilities/c0.89842663
132MP0005448_abnormal_energy_balance0.89216918
133MP0000462_abnormal_digestive_system0.89161880
134MP0003385_abnormal_body_wall0.88173946
135MP0005076_abnormal_cell_differentiation0.88092561
136MP0001502_abnormal_circadian_rhythm0.85561130
137MP0000762_abnormal_tongue_morphology0.85062608
138MP0003221_abnormal_cardiomyocyte_apopto0.84177916
139MP0000372_irregular_coat_pigmentation0.83783361
140MP0004043_abnormal_pH_regulation0.82634650
141MP0008569_lethality_at_weaning0.82393234
142MP0004085_abnormal_heartbeat0.81571967
143MP0001849_ear_inflammation0.81384918
144MP0000490_abnormal_crypts_of0.81219925
145MP0003936_abnormal_reproductive_system0.80658929
146MP0000647_abnormal_sebaceous_gland0.80463740
147MP0002796_impaired_skin_barrier0.80242689
148* MP0002069_abnormal_eating/drinking_beha0.79533516
149MP0003943_abnormal_hepatobiliary_system0.79423319
150MP0003755_abnormal_palate_morphology0.78446751
151MP0005084_abnormal_gallbladder_morpholo0.77481437
152* MP0003638_abnormal_response/metabolism_0.77410088
153MP0001177_atelectasis0.76738158
154MP0005083_abnormal_biliary_tract0.75957573
155MP0000383_abnormal_hair_follicle0.74783416
156MP0000579_abnormal_nail_morphology0.74730222
157MP0002092_abnormal_eye_morphology0.74663332
158MP0002148_abnormal_hypersensitivity_rea0.73772074
159MP0008874_decreased_physiological_sensi0.73060761
160MP0002882_abnormal_neuron_morphology0.72748918
161MP0003633_abnormal_nervous_system0.72028293
162MP0004270_analgesia0.71831840
163MP0009764_decreased_sensitivity_to0.71376306
164MP0008007_abnormal_cellular_replicative0.70750315
165MP0001485_abnormal_pinna_reflex0.69667203
166MP0002102_abnormal_ear_morphology0.69516529
167MP0004147_increased_porphyrin_level0.68790886
168MP0000778_abnormal_nervous_system0.68314213
169MP0004811_abnormal_neuron_physiology0.68187015
170MP0004885_abnormal_endolymph0.66671494
171MP0004233_abnormal_muscle_weight0.66488495
172MP0001984_abnormal_olfaction0.66391799
173MP0002163_abnormal_gland_morphology0.65918456
174MP0000013_abnormal_adipose_tissue0.65109442
175MP0005187_abnormal_penis_morphology0.65047571
176MP0003123_paternal_imprinting0.63878944
177MP0003631_nervous_system_phenotype0.63708908
178MP0003137_abnormal_impulse_conducting0.63400051
179MP0000627_abnormal_mammary_gland0.62299623
180MP0010678_abnormal_skin_adnexa0.62177556
181MP0002938_white_spotting0.61972236
182MP0000266_abnormal_heart_morphology0.61206857
183MP0000955_abnormal_spinal_cord0.60057976
184MP0000313_abnormal_cell_death0.59924621
185MP0010630_abnormal_cardiac_muscle0.59049324
186MP0000631_abnormal_neuroendocrine_gland0.58649119
187MP0002234_abnormal_pharynx_morphology0.58448626
188MP0001915_intracranial_hemorrhage0.56298029

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)7.04418846
2Focal motor seizures (HP:0011153)6.91694730
3Febrile seizures (HP:0002373)6.08611209
4Atonic seizures (HP:0010819)5.82984117
5Epileptic encephalopathy (HP:0200134)4.97487713
6Hepatoblastoma (HP:0002884)4.20628021
7Double outlet right ventricle (HP:0001719)4.13762602
8Congenital malformation of the right heart (HP:0011723)4.13762602
9Intestinal atresia (HP:0011100)4.07566897
10Poor suck (HP:0002033)4.06165501
11Anal stenosis (HP:0002025)3.89959934
12Abdominal situs inversus (HP:0003363)3.86557787
13Abnormality of abdominal situs (HP:0011620)3.86557787
14Abnormal hair whorl (HP:0010721)3.84944726
15Focal seizures (HP:0007359)3.84704852
16Blue irides (HP:0000635)3.64926437
17Aqueductal stenosis (HP:0002410)3.63936360
18Type 2 muscle fiber atrophy (HP:0003554)3.62151849
19Absent radius (HP:0003974)3.61002055
20Absence seizures (HP:0002121)3.59194025
21Parakeratosis (HP:0001036)3.52629202
22Dialeptic seizures (HP:0011146)3.47652731
23Esophageal atresia (HP:0002032)3.43792406
24Aplasia involving forearm bones (HP:0009822)3.37211188
25Absent forearm bone (HP:0003953)3.37211188
26Abnormality of the parathyroid morphology (HP:0011766)3.30088983
27Protruding tongue (HP:0010808)3.24187142
28Hypothermia (HP:0002045)3.11039458
29Polyphagia (HP:0002591)3.06946977
30Absent speech (HP:0001344)3.05204892
31Abnormal pancreas size (HP:0012094)3.03187346
32Absent eyebrow (HP:0002223)3.01401983
33Fair hair (HP:0002286)3.01159863
34Embryonal renal neoplasm (HP:0011794)3.00335373
35Bifid tongue (HP:0010297)2.98673030
36Muscle fiber atrophy (HP:0100295)2.97448583
37Labial hypoplasia (HP:0000066)2.88260475
38Hypoplastic female external genitalia (HP:0012815)2.86458581
39Generalized tonic-clonic seizures (HP:0002069)2.85210849
40Short humerus (HP:0005792)2.84929184
41Nephroblastoma (Wilms tumor) (HP:0002667)2.84473752
42Stenosis of the external auditory canal (HP:0000402)2.82136990
43Aplasia/hypoplasia of the humerus (HP:0006507)2.77025482
44Abnormal mitochondria in muscle tissue (HP:0008316)2.76664850
45Ependymoma (HP:0002888)2.76119950
46Thyroid-stimulating hormone excess (HP:0002925)2.74459941
47Broad-based gait (HP:0002136)2.73080243
48Oligomenorrhea (HP:0000876)2.72272679
49Failure to thrive in infancy (HP:0001531)2.66252577
50Abnormality of the neuromuscular junction (HP:0003398)2.65452977
51Fatigable weakness (HP:0003473)2.65452977
52Short hallux (HP:0010109)2.65298363
53Oligodactyly (hands) (HP:0001180)2.64573665
54Acute necrotizing encephalopathy (HP:0006965)2.64256654
55Abnormality of the septum pellucidum (HP:0007375)2.62651028
56Hyperthyroidism (HP:0000836)2.61290798
57Choanal stenosis (HP:0000452)2.61277264
58Progressive inability to walk (HP:0002505)2.60141313
59Abnormal umbilical cord blood vessels (HP:0011403)2.59431977
60Single umbilical artery (HP:0001195)2.59431977
61Abnormality of the fetal cardiovascular system (HP:0010948)2.59431977
62Medial flaring of the eyebrow (HP:0010747)2.57882230
63Colon cancer (HP:0003003)2.57323207
64Absent eyelashes (HP:0000561)2.53692197
65Carpal bone hypoplasia (HP:0001498)2.52169546
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.50379001
67Absent/shortened dynein arms (HP:0200106)2.50379001
68Anophthalmia (HP:0000528)2.50245323
69Spastic diplegia (HP:0001264)2.48879847
70Gastrointestinal atresia (HP:0002589)2.47587036
71Aplasia/Hypoplasia of the hallux (HP:0008362)2.46113015
72Generalized hypopigmentation of hair (HP:0011358)2.45198851
73Gait imbalance (HP:0002141)2.42465021
74Rectal fistula (HP:0100590)2.41395332
75Rectovaginal fistula (HP:0000143)2.41395332
76Chronic hepatic failure (HP:0100626)2.40358432
77Preaxial foot polydactyly (HP:0001841)2.40329930
78Absent septum pellucidum (HP:0001331)2.39999194
79Alveolar cell carcinoma (HP:0006519)2.39073824
80Chronic bronchitis (HP:0004469)2.34786046
81Nephrogenic diabetes insipidus (HP:0009806)2.33906387
82Myelomeningocele (HP:0002475)2.32747448
83Hemivertebrae (HP:0002937)2.32116995
84Congenital primary aphakia (HP:0007707)2.31764220
85Horseshoe kidney (HP:0000085)2.30352613
86Abnormal lung lobation (HP:0002101)2.28746017
87Progressive macrocephaly (HP:0004481)2.28721933
88Mixed hearing impairment (HP:0000410)2.27867494
89Abnormal connection of the cardiac segments (HP:0011545)2.27420775
90Abnormal ventriculo-arterial connection (HP:0011563)2.27420775
91Transposition of the great arteries (HP:0001669)2.27420775
92Chin dimple (HP:0010751)2.26283359
93Narrow nasal bridge (HP:0000446)2.24720899
94Abnormality of dental color (HP:0011073)2.23814323
95Fused cervical vertebrae (HP:0002949)2.23141386
96Gaze-evoked nystagmus (HP:0000640)2.22435337
97Intestinal fistula (HP:0100819)2.22110775
98Maternal diabetes (HP:0009800)2.21221222
99Hyperphosphatemia (HP:0002905)2.20924079
100Vaginal fistula (HP:0004320)2.18046275
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17524360
102Drooling (HP:0002307)2.17098991
103Excessive salivation (HP:0003781)2.17098991
104Broad thumb (HP:0011304)2.14631801
105White forelock (HP:0002211)2.14509997
106Follicular hyperkeratosis (HP:0007502)2.14362646
107Abnormal ciliary motility (HP:0012262)2.12747623
108Short middle phalanx of the 5th finger (HP:0004220)2.12442074
109Oligodontia (HP:0000677)2.11945757
110Split foot (HP:0001839)2.10057588
111Cortical dysplasia (HP:0002539)2.05494076
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03961151
113Partial duplication of thumb phalanx (HP:0009944)2.02360704
114Anal atresia (HP:0002023)2.02320249
115Unilateral renal agenesis (HP:0000122)2.01957105
116Growth hormone deficiency (HP:0000824)2.00902183
117Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00775694
118Short 1st metacarpal (HP:0010034)2.00775694
119Rhabdomyosarcoma (HP:0002859)2.00266748
120Congenital sensorineural hearing impairment (HP:0008527)2.00147095
121Gastrointestinal carcinoma (HP:0002672)1.99236036
122Malignant gastrointestinal tract tumors (HP:0006749)1.99236036
123Chromsome breakage (HP:0040012)1.98971040
124Omphalocele (HP:0001539)1.97314441
125Abnormality of the labia (HP:0000058)1.96474116
126Abnormality of the umbilical cord (HP:0010881)1.95708347
127Abnormal social behavior (HP:0012433)1.94199676
128Impaired social interactions (HP:0000735)1.94199676
129Cheilitis (HP:0100825)1.94123288
130Bilateral microphthalmos (HP:0007633)1.94098892
131Epileptiform EEG discharges (HP:0011182)1.93924702
132Optic nerve hypoplasia (HP:0000609)1.93200535
133Alopecia of scalp (HP:0002293)1.92954359
134Mitochondrial inheritance (HP:0001427)1.92870257
135Bulbar palsy (HP:0001283)1.92565518
136Triphalangeal thumb (HP:0001199)1.92100298
137Neoplasm of the tracheobronchial system (HP:0100552)1.91798984
138Deep palmar crease (HP:0006191)1.91008155
139Abnormality of the duodenum (HP:0002246)1.90901871
140Pancreatic fibrosis (HP:0100732)1.90803363
141Meckel diverticulum (HP:0002245)1.90660407
142Patchy hypopigmentation of hair (HP:0011365)1.90313152
143Thickened helices (HP:0000391)1.90098006
144Sensory axonal neuropathy (HP:0003390)1.90086239
145Inability to walk (HP:0002540)1.89762475
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.88665258
147Nuclear cataract (HP:0100018)1.87829995
148Medulloblastoma (HP:0002885)1.86986181
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.86603657
150Deviation of the thumb (HP:0009603)1.86432247
151Acute encephalopathy (HP:0006846)1.85627389
152Abnormality of salivation (HP:0100755)1.85392231
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84564636
154Renal hypoplasia (HP:0000089)1.84445851
155EEG with generalized epileptiform discharges (HP:0011198)1.84211664
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83791364
157Spinal canal stenosis (HP:0003416)1.83601833
158Septo-optic dysplasia (HP:0100842)1.83370346
159Biliary tract neoplasm (HP:0100574)1.83018660
160Abnormality of the ileum (HP:0001549)1.82915233
161Abnormality of methionine metabolism (HP:0010901)1.82181173
162Ectopic anus (HP:0004397)1.82094921
163Abnormal eating behavior (HP:0100738)1.81466805
164Cellular immunodeficiency (HP:0005374)1.81280479
165Hip dysplasia (HP:0001385)1.81147950
166Oligodactyly (HP:0012165)1.80825295
167Abnormality of the 1st metacarpal (HP:0010009)1.80085076
168Bifid scrotum (HP:0000048)1.79362350
169Abnormality of chromosome stability (HP:0003220)1.78998040
170Fetal akinesia sequence (HP:0001989)1.78599733
171Agnosia (HP:0010524)1.77673439
172Widely spaced teeth (HP:0000687)1.77485271
173Cupped ear (HP:0000378)1.76947705
174Esotropia (HP:0000565)1.75534523
175Generalized hypotonia (HP:0001290)1.75392641
176Neoplasm of the adrenal cortex (HP:0100641)1.75306973
177Abnormality of the labia minora (HP:0012880)1.74810728
178Retrobulbar optic neuritis (HP:0100654)1.74809266
179Optic neuritis (HP:0100653)1.74809266
180Hypsarrhythmia (HP:0002521)1.74535281
181True hermaphroditism (HP:0010459)1.73682712
182Weak cry (HP:0001612)1.73301101
183Tetany (HP:0001281)1.72866521
184Gonadotropin excess (HP:0000837)1.70202412
185Tubulointerstitial nephritis (HP:0001970)1.69836789
186Abnormality of calcium-phosphate metabolism (HP:0100530)1.69269384
187Submucous cleft hard palate (HP:0000176)1.67999075
188Aplasia/Hypoplasia of the lens (HP:0008063)1.67935677
189Pheochromocytoma (HP:0002666)1.67450629
190Bilateral sensorineural hearing impairment (HP:0008619)1.66726624
191Abnormal respiratory epithelium morphology (HP:0012253)1.66340743
192Abnormal respiratory motile cilium morphology (HP:0005938)1.66340743
193Abnormal respiratory motile cilium physiology (HP:0012261)1.64534723
194Recurrent corneal erosions (HP:0000495)1.62200275
195Large eyes (HP:0001090)1.62108680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.52099856
2SIK35.01412284
3AKT33.69512679
4PBK3.43738956
5NTRK33.40155763
6PRPF4B3.16035256
7TRIM283.01522682
8TSSK62.53418809
9TNIK2.53144138
10TTK2.52279157
11MAP2K72.51495924
12MAP3K122.38931823
13ADRBK22.32392536
14MUSK2.32147219
15CDC72.26839342
16ACVR1B2.22690837
17WEE12.11867188
18CDK192.09433754
19ERBB42.08229317
20CAMK1D2.03787890
21SIK21.85706749
22SRPK11.83723150
23BRSK21.81087452
24CDK81.81017441
25PLK41.80584041
26BUB11.78043316
27CAMK1G1.75974273
28PLK21.75833211
29PLK31.73142991
30PRKCE1.63959811
31LATS11.62027909
32SIK11.51008246
33NEK11.46192156
34BRD41.45918798
35MAP3K141.40105621
36FGFR11.40071388
37BMPR1B1.38872079
38YES11.38503448
39FGFR21.37216847
40PRKCG1.36558091
41IRAK31.33588158
42MKNK21.29093510
43NTRK21.29078431
44SGK21.28991834
45DYRK31.25657450
46MAP3K101.25449175
47TXK1.25110593
48SCYL21.20312163
49RIPK41.19675950
50EIF2AK31.19328557
51PLK11.18706430
52MAPK131.16030225
53BRAF1.15913548
54INSRR1.12694329
55LATS21.12438458
56BMPR21.11686824
57PAK41.11462760
58STK31.10387218
59MAP3K91.07276648
60EIF2AK11.05890013
61MAP3K41.03577328
62PNCK1.03276383
63NUAK11.00469320
64TNK21.00124167
65STK100.95793600
66TAF10.94350499
67VRK20.94309523
68MARK30.94214189
69FLT30.94138876
70NEK20.93614670
71BMX0.91154220
72GRK50.89779577
73CAMK2A0.86122848
74SGK2230.85526528
75SGK4940.85526528
76CHEK20.83336753
77PINK10.82849441
78MARK10.81801855
79MELK0.80343306
80ATR0.79772613
81MAP3K80.79352983
82BCR0.78992691
83MAP2K40.78740661
84CDK30.76382540
85SGK30.75252719
86DAPK10.74663630
87GRK70.74406348
88MATK0.73931036
89EPHA40.73418024
90IRAK20.73086581
91BRSK10.73044460
92CAMK2G0.71120229
93KIT0.71081754
94MET0.70705952
95CHEK10.69940811
96IRAK40.68452204
97ATM0.67223836
98PDK20.66796622
99ERBB30.66786199
100TGFBR10.64389037
101AURKB0.62153393
102PKN10.62001549
103CDK70.61680335
104OXSR10.61478545
105NLK0.60944646
106PRKCI0.58233656
107MINK10.54520971
108PASK0.53336153
109EIF2AK20.53132977
110FER0.52555784
111CCNB10.52469787
112PDGFRA0.51312431
113CSNK1G10.51298603
114MKNK10.49366650
115MST40.49140606
116NEK60.48723653
117TAOK20.46963420
118EGFR0.46293894
119RPS6KB10.45886147
120GRK10.45390625
121STK38L0.45070692
122MYLK0.44927290
123CDK10.44782991
124ADRBK10.44638314
125EPHA30.44631531
126WNK30.43163144
127IRAK10.43125130
128STK40.42790767
129PRKDC0.42263414
130PDK40.41461046
131PDK30.41461046
132SGK10.40598327
133ZAK0.39981948
134CDK20.38244620
135PRKCB0.38240829
136ALK0.37706743
137PTK20.37303124
138PRKCD0.37153338
139PKN20.37011174
140SMG10.36897621
141CAMK2B0.36677814
142PRKG10.36546178
143DYRK1A0.36063818
144TAOK30.35526729
145PRKACA0.35345259
146CDK50.35318132
147NME10.35170670
148DMPK0.35080665
149CDK120.35057906
150PRKCA0.33538218
151CAMK10.30450206
152LYN0.30088726
153RPS6KA40.29072678
154NTRK10.28695805
155STK160.28603898
156FES0.28368334
157CSNK1E0.28129136
158MTOR0.27889954
159DAPK20.27369326
160PAK10.26504279
161PRKCQ0.25853821
162SYK0.25826713
163MST1R0.25668853
164AURKA0.25378272
165EPHA20.24874534
166VRK10.24750751
167IGF1R0.24168814
168CAMK2D0.23851967
169SRC0.23529691
170FYN0.23465480
171CSF1R0.22959584

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.67861476
2Nicotine addiction_Homo sapiens_hsa050334.19993109
3Collecting duct acid secretion_Homo sapiens_hsa049664.06798286
4Synaptic vesicle cycle_Homo sapiens_hsa047213.74124215
5Non-homologous end-joining_Homo sapiens_hsa034503.37319043
6Mismatch repair_Homo sapiens_hsa034303.11022238
7Type I diabetes mellitus_Homo sapiens_hsa049402.78019846
8* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.75063421
9Proteasome_Homo sapiens_hsa030502.74125012
10DNA replication_Homo sapiens_hsa030302.73332885
11GABAergic synapse_Homo sapiens_hsa047272.68696035
12Morphine addiction_Homo sapiens_hsa050322.55097099
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53957917
14RNA transport_Homo sapiens_hsa030132.47207920
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.44917176
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33357172
17Rheumatoid arthritis_Homo sapiens_hsa053232.32875754
18Cell cycle_Homo sapiens_hsa041102.27587401
19Vibrio cholerae infection_Homo sapiens_hsa051102.27386870
20Selenocompound metabolism_Homo sapiens_hsa004502.22878062
21Oxidative phosphorylation_Homo sapiens_hsa001902.13854816
22Basal cell carcinoma_Homo sapiens_hsa052172.12200351
23TGF-beta signaling pathway_Homo sapiens_hsa043502.00244571
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.99124686
25Wnt signaling pathway_Homo sapiens_hsa043101.98469351
26Pyruvate metabolism_Homo sapiens_hsa006201.97807235
27mRNA surveillance pathway_Homo sapiens_hsa030151.93713676
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.93465095
29Basal transcription factors_Homo sapiens_hsa030221.92424891
30Base excision repair_Homo sapiens_hsa034101.91878690
31Adherens junction_Homo sapiens_hsa045201.91558286
32Glutamatergic synapse_Homo sapiens_hsa047241.91422299
33Taste transduction_Homo sapiens_hsa047421.90934354
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90144256
35Phagosome_Homo sapiens_hsa041451.83721694
36Hippo signaling pathway_Homo sapiens_hsa043901.81191770
37Serotonergic synapse_Homo sapiens_hsa047261.79483901
38Fanconi anemia pathway_Homo sapiens_hsa034601.79332849
39Homologous recombination_Homo sapiens_hsa034401.78674885
40Long-term depression_Homo sapiens_hsa047301.77930618
41Spliceosome_Homo sapiens_hsa030401.68852226
42Steroid biosynthesis_Homo sapiens_hsa001001.67361816
43Circadian entrainment_Homo sapiens_hsa047131.61973417
44Biosynthesis of amino acids_Homo sapiens_hsa012301.53381757
45RNA degradation_Homo sapiens_hsa030181.49872838
46Olfactory transduction_Homo sapiens_hsa047401.48974369
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48616978
48Propanoate metabolism_Homo sapiens_hsa006401.46036298
49Tight junction_Homo sapiens_hsa045301.46007408
50Nucleotide excision repair_Homo sapiens_hsa034201.40319495
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37363942
52Cholinergic synapse_Homo sapiens_hsa047251.35043097
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31746181
54p53 signaling pathway_Homo sapiens_hsa041151.30344828
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29399967
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29119566
57Lysine degradation_Homo sapiens_hsa003101.27742156
58Melanoma_Homo sapiens_hsa052181.24850381
59* Calcium signaling pathway_Homo sapiens_hsa040201.19912782
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.16188689
61Oocyte meiosis_Homo sapiens_hsa041141.16064146
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12993968
63Ovarian steroidogenesis_Homo sapiens_hsa049131.12969937
64RNA polymerase_Homo sapiens_hsa030201.08256047
65One carbon pool by folate_Homo sapiens_hsa006701.07246358
66Proteoglycans in cancer_Homo sapiens_hsa052051.04790273
67Thyroid cancer_Homo sapiens_hsa052161.04772290
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04477470
69Insulin secretion_Homo sapiens_hsa049111.03831390
70Carbon metabolism_Homo sapiens_hsa012001.03466280
71Butanoate metabolism_Homo sapiens_hsa006501.03429193
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02441030
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01002128
74Salivary secretion_Homo sapiens_hsa049701.00096948
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98811617
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98654652
77Dopaminergic synapse_Homo sapiens_hsa047280.97624255
78MicroRNAs in cancer_Homo sapiens_hsa052060.97245026
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96677821
80Melanogenesis_Homo sapiens_hsa049160.93047262
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90512043
82Alzheimers disease_Homo sapiens_hsa050100.89002233
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88963501
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87429990
85African trypanosomiasis_Homo sapiens_hsa051430.87399164
86Long-term potentiation_Homo sapiens_hsa047200.87265342
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86929506
88beta-Alanine metabolism_Homo sapiens_hsa004100.86200413
89Parkinsons disease_Homo sapiens_hsa050120.84390106
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82847397
91Colorectal cancer_Homo sapiens_hsa052100.82846015
92Hedgehog signaling pathway_Homo sapiens_hsa043400.82508217
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82188646
94Phototransduction_Homo sapiens_hsa047440.80592484
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79455661
96Fatty acid metabolism_Homo sapiens_hsa012120.74229286
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73979309
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70801212
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70466097
100Prostate cancer_Homo sapiens_hsa052150.70456347
101Amphetamine addiction_Homo sapiens_hsa050310.70230835
102N-Glycan biosynthesis_Homo sapiens_hsa005100.69539747
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.67062968
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65631700
105Huntingtons disease_Homo sapiens_hsa050160.65373203
106Protein export_Homo sapiens_hsa030600.65195988
107Autoimmune thyroid disease_Homo sapiens_hsa053200.64441364
108Pyrimidine metabolism_Homo sapiens_hsa002400.62648389
109Pancreatic secretion_Homo sapiens_hsa049720.62590395
110Tuberculosis_Homo sapiens_hsa051520.61183777
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59482241
112Arginine and proline metabolism_Homo sapiens_hsa003300.57849052
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55613243
114Purine metabolism_Homo sapiens_hsa002300.55048082
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54794535
116Ras signaling pathway_Homo sapiens_hsa040140.54428877
117Fatty acid elongation_Homo sapiens_hsa000620.54149378
118Glucagon signaling pathway_Homo sapiens_hsa049220.53295292
119Regulation of autophagy_Homo sapiens_hsa041400.53259950
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52238081
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51106854
122Vitamin digestion and absorption_Homo sapiens_hsa049770.50997384
123Renin secretion_Homo sapiens_hsa049240.50735743
124Asthma_Homo sapiens_hsa053100.50374965
125Ether lipid metabolism_Homo sapiens_hsa005650.49859520
126Graft-versus-host disease_Homo sapiens_hsa053320.47495768
127Sulfur metabolism_Homo sapiens_hsa009200.47017307
128ErbB signaling pathway_Homo sapiens_hsa040120.46377310
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46045268
130Glioma_Homo sapiens_hsa052140.44310335
131Gastric acid secretion_Homo sapiens_hsa049710.44107373
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.44095383
133Galactose metabolism_Homo sapiens_hsa000520.43997785
134Fatty acid biosynthesis_Homo sapiens_hsa000610.43508145
135Axon guidance_Homo sapiens_hsa043600.43132668
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42716597
137Glutathione metabolism_Homo sapiens_hsa004800.41556374
138cAMP signaling pathway_Homo sapiens_hsa040240.41540731
139Hematopoietic cell lineage_Homo sapiens_hsa046400.41487001
140Allograft rejection_Homo sapiens_hsa053300.40091811
141Cardiac muscle contraction_Homo sapiens_hsa042600.39889687
142Renin-angiotensin system_Homo sapiens_hsa046140.39136910
143Alcoholism_Homo sapiens_hsa050340.39085197
144Pathways in cancer_Homo sapiens_hsa052000.38424102
145Viral carcinogenesis_Homo sapiens_hsa052030.37373822
146Vitamin B6 metabolism_Homo sapiens_hsa007500.37006251
147Cocaine addiction_Homo sapiens_hsa050300.36806167
148Dilated cardiomyopathy_Homo sapiens_hsa054140.36088315
149Legionellosis_Homo sapiens_hsa051340.35670751
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35593863
151Type II diabetes mellitus_Homo sapiens_hsa049300.34610402
152Chemokine signaling pathway_Homo sapiens_hsa040620.34119810
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.34021638
154Lysosome_Homo sapiens_hsa041420.32508351
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32292786
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31264944
157Rap1 signaling pathway_Homo sapiens_hsa040150.31059217
158Oxytocin signaling pathway_Homo sapiens_hsa049210.30816035
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30025096
160Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29700391
161Sphingolipid metabolism_Homo sapiens_hsa006000.28907269
162Metabolic pathways_Homo sapiens_hsa011000.28371601
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28071847
164Systemic lupus erythematosus_Homo sapiens_hsa053220.26691954
165Mineral absorption_Homo sapiens_hsa049780.25927405
166MAPK signaling pathway_Homo sapiens_hsa040100.24835955
167ECM-receptor interaction_Homo sapiens_hsa045120.24650360
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24583976
169Fatty acid degradation_Homo sapiens_hsa000710.24484958
170Other glycan degradation_Homo sapiens_hsa005110.22951735
171Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22858198
172Phenylalanine metabolism_Homo sapiens_hsa003600.21979935
173Histidine metabolism_Homo sapiens_hsa003400.21680067
174Endometrial cancer_Homo sapiens_hsa052130.21670922
1752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20580851
176Arachidonic acid metabolism_Homo sapiens_hsa005900.20358892
177Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19371271
178Fat digestion and absorption_Homo sapiens_hsa049750.18617659
179Inositol phosphate metabolism_Homo sapiens_hsa005620.18586144
180Shigellosis_Homo sapiens_hsa051310.18131924
181Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.18016134
182AMPK signaling pathway_Homo sapiens_hsa041520.17961554
183Insulin signaling pathway_Homo sapiens_hsa049100.17154611

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