GRSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.95482984
2lysine catabolic process (GO:0006554)5.95482984
3tricarboxylic acid cycle (GO:0006099)5.21374922
42-oxoglutarate metabolic process (GO:0006103)4.79127153
5aspartate family amino acid catabolic process (GO:0009068)4.68386570
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55552783
7L-phenylalanine metabolic process (GO:0006558)4.55552783
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55317465
9L-phenylalanine catabolic process (GO:0006559)4.55317465
10cysteine metabolic process (GO:0006534)4.44639361
11ribosome assembly (GO:0042255)4.40818130
12NADH metabolic process (GO:0006734)4.38657465
13carnitine shuttle (GO:0006853)4.38470050
14glyoxylate metabolic process (GO:0046487)4.30317460
15fatty acid transmembrane transport (GO:1902001)4.27866842
16oxaloacetate metabolic process (GO:0006107)4.21385240
17serine family amino acid catabolic process (GO:0009071)4.21153402
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.18532755
19kynurenine metabolic process (GO:0070189)4.08200775
20homocysteine metabolic process (GO:0050667)3.98824715
21muscle filament sliding (GO:0030049)3.95537646
22actin-myosin filament sliding (GO:0033275)3.95537646
23alpha-linolenic acid metabolic process (GO:0036109)3.92947400
24aromatic amino acid family catabolic process (GO:0009074)3.92831109
25tricarboxylic acid metabolic process (GO:0072350)3.91265203
26acetyl-CoA metabolic process (GO:0006084)3.87620275
27amino-acid betaine metabolic process (GO:0006577)3.85601978
28dicarboxylic acid biosynthetic process (GO:0043650)3.84220305
29cellular ketone body metabolic process (GO:0046950)3.83969937
30regulation of acyl-CoA biosynthetic process (GO:0050812)3.82624811
31nuclear pore organization (GO:0006999)3.74677025
32succinate metabolic process (GO:0006105)3.73605742
33fatty acid beta-oxidation (GO:0006635)3.72779709
34positive regulation of fatty acid beta-oxidation (GO:0032000)3.72459216
35fatty acid homeostasis (GO:0055089)3.71664753
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.70794815
37regulation of cofactor metabolic process (GO:0051193)3.70733120
38regulation of coenzyme metabolic process (GO:0051196)3.70733120
39sulfur amino acid catabolic process (GO:0000098)3.69330282
40glycine metabolic process (GO:0006544)3.67180534
41nuclear pore complex assembly (GO:0051292)3.65502411
42alpha-amino acid catabolic process (GO:1901606)3.60673479
43establishment of integrated proviral latency (GO:0075713)3.60638433
44regulation of fatty acid beta-oxidation (GO:0031998)3.59434784
45negative regulation of fatty acid biosynthetic process (GO:0045717)3.56087730
46branched-chain amino acid catabolic process (GO:0009083)3.55360413
47DNA unwinding involved in DNA replication (GO:0006268)3.53320515
48short-chain fatty acid metabolic process (GO:0046459)3.53165242
49glutamate metabolic process (GO:0006536)3.51958871
50mitotic sister chromatid cohesion (GO:0007064)3.51217159
51serine family amino acid metabolic process (GO:0009069)3.50628902
52fatty acid oxidation (GO:0019395)3.49071303
53valine metabolic process (GO:0006573)3.48570860
54cellular amino acid catabolic process (GO:0009063)3.47152257
55actin-mediated cell contraction (GO:0070252)3.46883204
56COPI coating of Golgi vesicle (GO:0048205)3.45944867
57Golgi transport vesicle coating (GO:0048200)3.45944867
58regulation of translational fidelity (GO:0006450)3.44904683
59regulation of fatty acid oxidation (GO:0046320)3.43551755
60indole-containing compound catabolic process (GO:0042436)3.42752443
61indolalkylamine catabolic process (GO:0046218)3.42752443
62tryptophan catabolic process (GO:0006569)3.42752443
63lipid oxidation (GO:0034440)3.40111677
64IMP metabolic process (GO:0046040)3.39634034
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.39524368
66urea cycle (GO:0000050)3.38555633
67urea metabolic process (GO:0019627)3.38555633
68amino-acid betaine transport (GO:0015838)3.37893686
69carnitine transport (GO:0015879)3.37893686
70tryptophan metabolic process (GO:0006568)3.34844324
71branched-chain amino acid metabolic process (GO:0009081)3.33046017
72cellular modified amino acid catabolic process (GO:0042219)3.32592351
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.31619777
74positive regulation of fatty acid oxidation (GO:0046321)3.31547548
75carnitine transmembrane transport (GO:1902603)3.31430248
76carnitine metabolic process (GO:0009437)3.30953023
77fatty acid catabolic process (GO:0009062)3.30458102
78ketone body metabolic process (GO:1902224)3.29852895
79biotin metabolic process (GO:0006768)3.29775548
80protein complex localization (GO:0031503)3.22268801
81bile acid biosynthetic process (GO:0006699)3.22122807
82formation of translation preinitiation complex (GO:0001731)3.21764617
83COPII vesicle coating (GO:0048208)3.20163340
84mitotic metaphase plate congression (GO:0007080)3.18577174
85regulation of sulfur metabolic process (GO:0042762)3.17134399
86cellular protein complex localization (GO:0034629)3.15625734
87protein localization to chromosome, centromeric region (GO:0071459)3.14276746
88IMP biosynthetic process (GO:0006188)3.13950286
894-hydroxyproline metabolic process (GO:0019471)3.12929659
90monocarboxylic acid catabolic process (GO:0072329)3.12276860
91carboxylic acid catabolic process (GO:0046395)3.09585483
92organic acid catabolic process (GO:0016054)3.09585483
93mitotic chromosome condensation (GO:0007076)3.08295642
94nitrogen cycle metabolic process (GO:0071941)3.05682531
95dicarboxylic acid catabolic process (GO:0043649)3.03482427
96negative regulation of potassium ion transmembrane transport (GO:1901380)3.03329844
97negative regulation of fibrinolysis (GO:0051918)2.98009248
98dicarboxylic acid metabolic process (GO:0043648)2.97909338
99negative regulation of fatty acid metabolic process (GO:0045922)2.97739715
100gluconeogenesis (GO:0006094)2.97291042
101serine family amino acid biosynthetic process (GO:0009070)2.97193878
102aromatic amino acid family metabolic process (GO:0009072)2.97180239
103regulation of protein activation cascade (GO:2000257)2.97169080
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95456523
105protein localization to kinetochore (GO:0034501)2.94900814
106acylglycerol homeostasis (GO:0055090)2.94535986
107triglyceride homeostasis (GO:0070328)2.94535986
108drug catabolic process (GO:0042737)2.94317591
109metaphase plate congression (GO:0051310)2.93421862
110complement activation, alternative pathway (GO:0006957)2.88730895
111urate metabolic process (GO:0046415)2.87027004
112ethanol oxidation (GO:0006069)2.86071678
113epoxygenase P450 pathway (GO:0019373)2.85275050
114high-density lipoprotein particle remodeling (GO:0034375)2.85217263
115coenzyme catabolic process (GO:0009109)2.84242604
116bile acid metabolic process (GO:0008206)2.81323461
117regulation of complement activation (GO:0030449)2.80815461
118regulation of translational elongation (GO:0006448)2.80615350
119regulation of triglyceride catabolic process (GO:0010896)2.80316110
120regulation of sequestering of triglyceride (GO:0010889)2.80064770
121quaternary ammonium group transport (GO:0015697)2.79789549
122regulation of cholesterol homeostasis (GO:2000188)2.78682308
123hexose biosynthetic process (GO:0019319)2.77564756
124drug transmembrane transport (GO:0006855)2.77563473
125tyrosine metabolic process (GO:0006570)2.76343083
126regulation of centriole replication (GO:0046599)2.76208370
127sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75735873
128tRNA aminoacylation for protein translation (GO:0006418)2.74346312
129non-recombinational repair (GO:0000726)2.73819689
130double-strand break repair via nonhomologous end joining (GO:0006303)2.73819689
131regulation of sister chromatid cohesion (GO:0007063)2.71310260
132CENP-A containing nucleosome assembly (GO:0034080)2.71075684
133nucleobase-containing small molecule interconversion (GO:0015949)2.68627093
134amino acid activation (GO:0043038)2.67551291
135tRNA aminoacylation (GO:0043039)2.67551291
136establishment of viral latency (GO:0019043)2.64463142
137oxidative phosphorylation (GO:0006119)2.63905586
138sarcomere organization (GO:0045214)2.63324355
139paraxial mesoderm development (GO:0048339)2.61799053
140folic acid-containing compound biosynthetic process (GO:0009396)2.60970838
141DNA replication-dependent nucleosome organization (GO:0034723)2.60832274
142DNA replication-dependent nucleosome assembly (GO:0006335)2.60832274
143positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60701146
144glycolytic process (GO:0006096)2.59377862
145skeletal muscle contraction (GO:0003009)2.58231790
146positive regulation of chromosome segregation (GO:0051984)2.58063107
147establishment of chromosome localization (GO:0051303)2.56159290
148protein maturation by protein folding (GO:0022417)2.53536377
149actin filament-based movement (GO:0030048)2.50488185
150chromatin remodeling at centromere (GO:0031055)2.50204871
151positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46415664
152purine nucleobase biosynthetic process (GO:0009113)2.42596862
153pore complex assembly (GO:0046931)2.41955448
154mitochondrial fusion (GO:0008053)2.41231712
155peptidyl-arginine omega-N-methylation (GO:0035247)2.39221516
156glucan biosynthetic process (GO:0009250)2.38476429
157glycogen biosynthetic process (GO:0005978)2.38476429
158ribonucleoprotein complex disassembly (GO:0032988)2.36935382
159proteasome assembly (GO:0043248)2.36417405
160mitochondrial DNA metabolic process (GO:0032042)2.36175644
161deoxyribonucleotide biosynthetic process (GO:0009263)2.35754880
162ribosome biogenesis (GO:0042254)2.34962182
163mitotic nuclear envelope disassembly (GO:0007077)2.34938972
164sister chromatid segregation (GO:0000819)2.34872698
165mitotic nuclear envelope reassembly (GO:0007084)2.34487355
166nuclear envelope reassembly (GO:0031468)2.34487355
167glutamine metabolic process (GO:0006541)2.33780348
168regulation of mitochondrial translation (GO:0070129)2.32308929
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.31466866
170positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31466866
171positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31466866
172mitotic sister chromatid segregation (GO:0000070)2.30419189
173DNA strand elongation involved in DNA replication (GO:0006271)2.28509529
174mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.28159810
175retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.27918364
176negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26254154
177ventricular cardiac muscle cell development (GO:0055015)2.26069786
178DNA topological change (GO:0006265)2.25717167
179DNA strand elongation (GO:0022616)2.25378294
180protein localization to microtubule (GO:0035372)2.24237935
181histone exchange (GO:0043486)2.22177620
182pteridine-containing compound biosynthetic process (GO:0042559)2.21896315
183striated muscle contraction (GO:0006941)2.20373720
184membrane disassembly (GO:0030397)2.19037873
185nuclear envelope disassembly (GO:0051081)2.19037873
186peptidyl-arginine N-methylation (GO:0035246)2.18716776
187peptidyl-arginine methylation (GO:0018216)2.18716776
188DNA ligation (GO:0006266)2.18364528
189notochord development (GO:0030903)2.18212210
190DNA replication-independent nucleosome organization (GO:0034724)2.18158573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.08079530
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16163883
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.00179221
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.47222560
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.84071748
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.41299310
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98415553
8ZNF263_19887448_ChIP-Seq_K562_Human2.94394214
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.93721767
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.92718203
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67998203
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67794478
13CLOCK_20551151_ChIP-Seq_293T_Human2.52620432
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.48677958
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42987667
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39852927
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31617060
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27885366
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26086113
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24042674
21DCP1A_22483619_ChIP-Seq_HELA_Human2.20987710
22YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17276842
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.10471857
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09859728
25ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08912270
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06054968
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04391215
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03373859
29E2F7_22180533_ChIP-Seq_HELA_Human2.03191772
30ELK1_19687146_ChIP-ChIP_HELA_Human2.02027884
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.01968149
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99612141
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99359442
34AR_21909140_ChIP-Seq_LNCAP_Human1.98029300
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91203265
36* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83419973
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82118629
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.80820234
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75653249
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73763541
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71884773
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70434167
43* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70241419
44XRN2_22483619_ChIP-Seq_HELA_Human1.68214821
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67530285
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67439568
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.59973128
48TTF2_22483619_ChIP-Seq_HELA_Human1.59355511
49* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56925960
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56908333
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55075823
52* GABP_19822575_ChIP-Seq_HepG2_Human1.52168720
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.50842663
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48733821
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47828861
56* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.46895524
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.46543143
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44812264
59SOX17_20123909_ChIP-Seq_XEN_Mouse1.38767310
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36734162
61* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34634300
62VDR_23849224_ChIP-Seq_CD4+_Human1.33799468
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.33323720
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29564618
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29233649
66* NANOG_21062744_ChIP-ChIP_HESCs_Human1.28646004
67* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28248911
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.25572552
69TFEB_21752829_ChIP-Seq_HELA_Human1.25544641
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25250656
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23965821
72* MYC_18555785_ChIP-Seq_MESCs_Mouse1.23685076
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23266184
74GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.21765960
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20268384
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20123800
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19740935
78FOXP3_21729870_ChIP-Seq_TREG_Human1.18522969
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17476082
80ATF3_27146783_Chip-Seq_COLON_Human1.17166305
81* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16960708
82HNF4A_19822575_ChIP-Seq_HepG2_Human1.16450671
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16140452
84FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15904400
85CHD1_26751641_Chip-Seq_LNCaP_Human1.15377763
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.15183581
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15139373
88* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15082472
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14982058
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13957437
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13025709
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11881706
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11765647
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09921206
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07864938
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07862245
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07384128
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.06655615
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.06655615
100FUS_26573619_Chip-Seq_HEK293_Human1.05100045
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04272382
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03633894
103KDM5A_27292631_Chip-Seq_BREAST_Human1.03194566
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01418632
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01177259
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00677282
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99525633
108GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98238850
109* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97449399
110* NANOG_16518401_ChIP-PET_MESCs_Mouse0.97237949
111REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97012985
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.96892219
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96872207
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96391991
115POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96040468
116* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95575690
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95449155
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94890718
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94422887
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94116793
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94027508
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93109090
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93097935
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92437678
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91724624
126EGR1_19374776_ChIP-ChIP_THP-1_Human0.91215642
127EWS_26573619_Chip-Seq_HEK293_Human0.90276442
128SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89066861
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88615089
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.88603432
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88582078
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87008533
133TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86781075
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85451653
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83861163
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83737888
137GATA6_25053715_ChIP-Seq_YYC3_Human0.83192109
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82697947
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82651362
140E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81914256
141OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81869017
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.81512105
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80642835
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80457164
145MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79913032
146* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79843595
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.79700277
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79540363
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.78598663
150* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78481595
151* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78172407
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77274034
153* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76814574
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74957225
155CREB1_26743006_Chip-Seq_LNCaP_Human0.74694204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.22643889
2MP0005360_urolithiasis4.39559102
3MP0005085_abnormal_gallbladder_physiolo4.37809606
4MP0005365_abnormal_bile_salt4.30284168
5MP0002837_dystrophic_cardiac_calcinosis3.27551635
6MP0003806_abnormal_nucleotide_metabolis2.88859182
7MP0003252_abnormal_bile_duct2.70810144
8MP0008875_abnormal_xenobiotic_pharmacok2.69667608
9MP0003646_muscle_fatigue2.62790877
10MP0010094_abnormal_chromosome_stability2.53946296
11MP0003941_abnormal_skin_development2.39284397
12MP0003111_abnormal_nucleus_morphology2.37201500
13MP0003705_abnormal_hypodermis_morpholog2.34850588
14MP0004084_abnormal_cardiac_muscle2.29271939
15MP0000013_abnormal_adipose_tissue2.21791057
16MP0005332_abnormal_amino_acid2.19163350
17MP0008057_abnormal_DNA_replication2.18655929
18MP0010329_abnormal_lipoprotein_level2.18339068
19MP0004130_abnormal_muscle_cell2.08614354
20MP0003195_calcinosis2.04046732
21MP0003693_abnormal_embryo_hatching2.03248290
22MP0003077_abnormal_cell_cycle1.95959439
23MP0004215_abnormal_myocardial_fiber1.91989656
24MP0005083_abnormal_biliary_tract1.90486081
25MP0003123_paternal_imprinting1.78234883
26MP0008932_abnormal_embryonic_tissue1.74739311
27MP0006036_abnormal_mitochondrial_physio1.72868631
28MP0005330_cardiomyopathy1.69392018
29MP0004036_abnormal_muscle_relaxation1.68624520
30MP0001666_abnormal_nutrient_absorption1.66653045
31MP0000751_myopathy1.64541827
32MP0004043_abnormal_pH_regulation1.62945729
33MP0002269_muscular_atrophy1.60628498
34MP0003221_abnormal_cardiomyocyte_apopto1.59704644
35MP0005666_abnormal_adipose_tissue1.59335207
36MP0009840_abnormal_foam_cell1.57675233
37MP0004185_abnormal_adipocyte_glucose1.56220878
38MP0004233_abnormal_muscle_weight1.50731859
39MP0009697_abnormal_copulation1.50606495
40MP0009780_abnormal_chondrocyte_physiolo1.49339757
41MP0002009_preneoplasia1.47387504
42MP0004270_analgesia1.42326274
43MP0004087_abnormal_muscle_fiber1.40861305
44MP0002118_abnormal_lipid_homeostasis1.38953917
45MP0008058_abnormal_DNA_repair1.38600492
46MP0005319_abnormal_enzyme/_coenzyme1.37302624
47MP0010234_abnormal_vibrissa_follicle1.36590254
48MP0000609_abnormal_liver_physiology1.35473531
49MP0000350_abnormal_cell_proliferation1.30690772
50MP0001661_extended_life_span1.25337292
51MP0003283_abnormal_digestive_organ1.25074063
52MP0000733_abnormal_muscle_development1.25029971
53MP0002078_abnormal_glucose_homeostasis1.21984951
54MP0002080_prenatal_lethality1.21129101
55MP0004272_abnormal_basement_membrane1.21074743
56MP0001299_abnormal_eye_distance/1.19877909
57MP0004019_abnormal_vitamin_homeostasis1.18408275
58MP0003868_abnormal_feces_composition1.18014373
59MP0008775_abnormal_heart_ventricle1.17841265
60MP0006138_congestive_heart_failure1.17706862
61MP0010630_abnormal_cardiac_muscle1.17653005
62MP0002972_abnormal_cardiac_muscle1.16866279
63MP0002085_abnormal_embryonic_tissue1.16622576
64MP0003385_abnormal_body_wall1.15380729
65MP0001529_abnormal_vocalization1.15320823
66MP0002909_abnormal_adrenal_gland1.15241852
67MP0000747_muscle_weakness1.14839762
68MP0005620_abnormal_muscle_contractility1.14360088
69MP0009672_abnormal_birth_weight1.14277306
70MP0005623_abnormal_meninges_morphology1.12740776
71MP0005187_abnormal_penis_morphology1.12066531
72MP0004147_increased_porphyrin_level1.11510708
73MP0006035_abnormal_mitochondrial_morpho1.11458265
74MP0005385_cardiovascular_system_phenoty1.09679240
75MP0001544_abnormal_cardiovascular_syste1.09679240
76MP0005670_abnormal_white_adipose1.09668785
77MP0000358_abnormal_cell_content/1.09416367
78MP0002877_abnormal_melanocyte_morpholog1.09255009
79MP0009643_abnormal_urine_homeostasis1.07390391
80MP0004264_abnormal_extraembryonic_tissu1.06132388
81MP0005266_abnormal_metabolism1.05869968
82MP0008007_abnormal_cellular_replicative1.03991974
83MP0000750_abnormal_muscle_regeneration1.03901723
84MP0003567_abnormal_fetal_cardiomyocyte1.03207633
85MP0003937_abnormal_limbs/digits/tail_de1.02561197
86MP0008877_abnormal_DNA_methylation0.99972329
87MP0002088_abnormal_embryonic_growth/wei0.99875120
88MP0000749_muscle_degeneration0.99549156
89MP0005584_abnormal_enzyme/coenzyme_acti0.99371368
90MP0002971_abnormal_brown_adipose0.99203026
91MP0008961_abnormal_basal_metabolism0.99086042
92MP0001730_embryonic_growth_arrest0.98427540
93MP0003984_embryonic_growth_retardation0.98278676
94MP0002106_abnormal_muscle_physiology0.97026054
95MP0005220_abnormal_exocrine_pancreas0.96718162
96MP0003191_abnormal_cellular_cholesterol0.93873819
97MP0005380_embryogenesis_phenotype0.93597440
98MP0001672_abnormal_embryogenesis/_devel0.93597440
99MP0005375_adipose_tissue_phenotype0.92954770
100MP0000462_abnormal_digestive_system0.92497881
101MP0005451_abnormal_body_composition0.92264526
102MP0003121_genomic_imprinting0.92031569
103MP0003718_maternal_effect0.91450147
104MP0002697_abnormal_eye_size0.91337650
105MP0009053_abnormal_anal_canal0.90852149
106MP0001756_abnormal_urination0.89966719
107MP0002127_abnormal_cardiovascular_syste0.89811594
108MP0003890_abnormal_embryonic-extraembry0.88633856
109MP0004145_abnormal_muscle_electrophysio0.88217888
110MP0010352_gastrointestinal_tract_polyps0.87629770
111MP0003137_abnormal_impulse_conducting0.87107058
112MP0000537_abnormal_urethra_morphology0.85891040
113MP0003122_maternal_imprinting0.85714837
114MP0005171_absent_coat_pigmentation0.85105692
115MP0002234_abnormal_pharynx_morphology0.84206576
116MP0000598_abnormal_liver_morphology0.83675822
117MP0005367_renal/urinary_system_phenotyp0.83398101
118MP0000516_abnormal_urinary_system0.83398101
119MP0004197_abnormal_fetal_growth/weight/0.83184548
120MP0004085_abnormal_heartbeat0.82982369
121MP0003786_premature_aging0.82355280
122MP0010307_abnormal_tumor_latency0.81740334
123MP0008438_abnormal_cutaneous_collagen0.81176800
124MP0000759_abnormal_skeletal_muscle0.80966568
125MP0002332_abnormal_exercise_endurance0.79553147
126MP0002084_abnormal_developmental_patter0.79224171
127MP0002086_abnormal_extraembryonic_tissu0.79162625
128MP0002090_abnormal_vision0.79122976
129MP0004957_abnormal_blastocyst_morpholog0.78246219
130MP0001764_abnormal_homeostasis0.78161473
131MP0002177_abnormal_outer_ear0.77289237
132MP0009703_decreased_birth_body0.76718950
133MP0005369_muscle_phenotype0.76513879
134MP0001697_abnormal_embryo_size0.76467924
135MP0006072_abnormal_retinal_apoptosis0.76217572
136MP0000762_abnormal_tongue_morphology0.75815837
137MP0002138_abnormal_hepatobiliary_system0.74733954
138MP0004484_altered_response_of0.74325443
139MP0002233_abnormal_nose_morphology0.73117940
140MP0005384_cellular_phenotype0.71415075
141MP0000428_abnormal_craniofacial_morphol0.71023249
142MP0005501_abnormal_skin_physiology0.70839690
143MP0000372_irregular_coat_pigmentation0.69939216
144MP0003119_abnormal_digestive_system0.69927990
145MP0001944_abnormal_pancreas_morphology0.69538597
146MP0002653_abnormal_ependyma_morphology0.68674524
147MP0000266_abnormal_heart_morphology0.67972700
148MP0001188_hyperpigmentation0.67315109
149MP0005334_abnormal_fat_pad0.67277589
150MP0000003_abnormal_adipose_tissue0.66336996
151MP0001346_abnormal_lacrimal_gland0.65526172

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.92141372
2Muscle fiber inclusion bodies (HP:0100299)5.77646336
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.66416703
4Hypoglycemic coma (HP:0001325)4.55639578
5Ketoacidosis (HP:0001993)4.22671567
6Hyperglycinuria (HP:0003108)4.14358943
7Ketosis (HP:0001946)4.10916948
8Hyperglycinemia (HP:0002154)4.05864363
9Gout (HP:0001997)3.94093414
10Hyperammonemia (HP:0001987)3.92559155
11Myoglobinuria (HP:0002913)3.83700113
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.81042974
13Abnormality of glycine metabolism (HP:0010895)3.73936123
14Abnormality of serine family amino acid metabolism (HP:0010894)3.73936123
15Type 1 muscle fiber predominance (HP:0003803)3.73224645
16Intrahepatic cholestasis (HP:0001406)3.66278063
17Exercise-induced muscle cramps (HP:0003710)3.53404560
18Deep venous thrombosis (HP:0002625)3.50926194
19Distal arthrogryposis (HP:0005684)3.49176043
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.46274403
21Hypobetalipoproteinemia (HP:0003563)3.37154527
22Xanthomatosis (HP:0000991)3.21786307
23Subaortic stenosis (HP:0001682)3.19361022
24Abnormality of the left ventricular outflow tract (HP:0011103)3.19361022
25Hyperinsulinemic hypoglycemia (HP:0000825)3.14150332
26Abnormality of fatty-acid metabolism (HP:0004359)3.13812622
27Rimmed vacuoles (HP:0003805)3.13429014
28Rhabdomyolysis (HP:0003201)3.09419986
29Muscle hypertrophy of the lower extremities (HP:0008968)3.05294713
30Hypoglycemic seizures (HP:0002173)3.04126637
31Hypolipoproteinemia (HP:0010981)3.00192021
32Hyperglycemia (HP:0003074)2.96158808
33Hypoalphalipoproteinemia (HP:0003233)2.96080048
34Abnormality of serum amino acid levels (HP:0003112)2.92646974
35Progressive muscle weakness (HP:0003323)2.85424501
36Calcaneovalgus deformity (HP:0001848)2.82902493
37Abnormality of the lower motor neuron (HP:0002366)2.82665373
38Sudden death (HP:0001699)2.79917982
39Increased purine levels (HP:0004368)2.78835204
40Hyperuricemia (HP:0002149)2.78835204
41Exercise-induced myalgia (HP:0003738)2.75345467
42EMG: myopathic abnormalities (HP:0003458)2.73174555
43Abnormality of purine metabolism (HP:0004352)2.72450327
44Dicarboxylic aciduria (HP:0003215)2.68348360
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68348360
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.67639148
47Shoulder girdle muscle weakness (HP:0003547)2.66266669
48Abnormality of the calf musculature (HP:0001430)2.56484987
49Epidermoid cyst (HP:0200040)2.54101343
50Spastic diplegia (HP:0001264)2.52751897
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52374812
52Abnormality of the intrinsic pathway (HP:0010989)2.50273633
53Deformed tarsal bones (HP:0008119)2.49794886
54Complement deficiency (HP:0004431)2.49416526
55Limb-girdle muscle atrophy (HP:0003797)2.47369931
56Abnormality of the musculature of the pelvis (HP:0001469)2.46392314
57Abnormality of the hip-girdle musculature (HP:0001445)2.46392314
58Skin nodule (HP:0200036)2.45268322
59Metabolic acidosis (HP:0001942)2.45061631
60Abnormality of alanine metabolism (HP:0010916)2.42376188
61Hyperalaninemia (HP:0003348)2.42376188
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42376188
63Abnormality of nucleobase metabolism (HP:0010932)2.42371332
64Myopathic facies (HP:0002058)2.42136199
65Hyperlipoproteinemia (HP:0010980)2.38925046
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38855662
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37768341
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36198439
69Late onset (HP:0003584)2.35223374
70Palpitations (HP:0001962)2.35083858
71Lethargy (HP:0001254)2.34386004
72Cerebral edema (HP:0002181)2.33683031
73Lymphangioma (HP:0100764)2.33093627
74Hamartoma of the eye (HP:0010568)2.30109762
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.28066727
76Pelvic girdle muscle weakness (HP:0003749)2.27675928
77Neck muscle weakness (HP:0000467)2.26079553
78Microvesicular hepatic steatosis (HP:0001414)2.25981176
79Atrioventricular block (HP:0001678)2.25427468
80Hepatocellular carcinoma (HP:0001402)2.20714597
81Delayed CNS myelination (HP:0002188)2.17121692
82Proximal tubulopathy (HP:0000114)2.16589818
83Round ear (HP:0100830)2.16440394
84Areflexia of lower limbs (HP:0002522)2.16407273
85Bundle branch block (HP:0011710)2.16129810
86Microglossia (HP:0000171)2.15700020
87Absent phalangeal crease (HP:0006109)2.13515065
88Generalized aminoaciduria (HP:0002909)2.12650171
89Ependymoma (HP:0002888)2.12358680
90Prolonged partial thromboplastin time (HP:0003645)2.10942362
91Muscle stiffness (HP:0003552)2.08540853
92Right ventricular cardiomyopathy (HP:0011663)2.07459286
93Adenoma sebaceum (HP:0009720)2.06742240
94Angiofibromas (HP:0010615)2.06742240
95Ragged-red muscle fibers (HP:0003200)2.06701780
96Popliteal pterygium (HP:0009756)2.06658453
97Ventricular tachycardia (HP:0004756)2.04629551
98Progressive external ophthalmoplegia (HP:0000590)2.04305396
99Abnormality of methionine metabolism (HP:0010901)2.03204293
100Abnormality of the common coagulation pathway (HP:0010990)2.02573367
101Papillary thyroid carcinoma (HP:0002895)2.01601278
102Hypochromic microcytic anemia (HP:0004840)1.99582904
103Conjunctival hamartoma (HP:0100780)1.98739066
104Muscle fiber splitting (HP:0003555)1.98160556
105Pancreatic islet-cell hyperplasia (HP:0004510)1.98159821
106Abnormality of endocrine pancreas physiology (HP:0012093)1.95025469
107Abnormality of the pancreatic islet cells (HP:0006476)1.95025469
108Calf muscle hypertrophy (HP:0008981)1.92444279
109Cholelithiasis (HP:0001081)1.92259792
110Pheochromocytoma (HP:0002666)1.92174669
111Abnormal finger flexion creases (HP:0006143)1.91981716
112Neoplasm of the adrenal gland (HP:0100631)1.91606766
113Back pain (HP:0003418)1.89475494
114Hyporeflexia of lower limbs (HP:0002600)1.89354790
115Increased connective tissue (HP:0009025)1.87049481
116Breech presentation (HP:0001623)1.86890274
117Abnormality of skeletal muscle fiber size (HP:0012084)1.86519405
118Abnormal cartilage morphology (HP:0002763)1.86005617
119Insulin-resistant diabetes mellitus (HP:0000831)1.85691929
120Neonatal onset (HP:0003623)1.85643616
121Symptomatic seizures (HP:0011145)1.85074330
122Oligomenorrhea (HP:0000876)1.84623847
123Limb-girdle muscle weakness (HP:0003325)1.83489752
124Asymmetric septal hypertrophy (HP:0001670)1.83218390
125Abnormality of the calcaneus (HP:0008364)1.82224436
126Abnormality of pyrimidine metabolism (HP:0004353)1.82213342
127Heart block (HP:0012722)1.81463222
128Abnormal gallbladder morphology (HP:0012437)1.81148911
129Fat malabsorption (HP:0002630)1.80383508
130Multiple enchondromatosis (HP:0005701)1.80324331
131Abnormality of glycolysis (HP:0004366)1.78896709
132Increased serum pyruvate (HP:0003542)1.78896709
133Biliary tract neoplasm (HP:0100574)1.78200105
134Vomiting (HP:0002013)1.78098798
135Difficulty running (HP:0009046)1.75776155
136Septate vagina (HP:0001153)1.75224235
137Rhabdomyosarcoma (HP:0002859)1.71427024
138Mildly elevated creatine phosphokinase (HP:0008180)1.70579307
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69403164
140Neoplasm of the small intestine (HP:0100833)1.63689514
141Myotonia (HP:0002486)1.60623862
142Abnormality of the shoulder girdle musculature (HP:0001435)1.60463787
143Termporal pattern (HP:0011008)1.59621505
144Insidious onset (HP:0003587)1.59621505
145Thyroid carcinoma (HP:0002890)1.59209238
146Abnormality of placental membranes (HP:0011409)1.58919271
147Amniotic constriction ring (HP:0009775)1.58919271
148Neuroendocrine neoplasm (HP:0100634)1.57846536
149Postnatal microcephaly (HP:0005484)1.57482201
150Exercise intolerance (HP:0003546)1.57096801
151Unilateral renal agenesis (HP:0000122)1.56768985
152Neoplasm of the rectum (HP:0100743)1.55612487
153Pterygium (HP:0001059)1.55612065
154Long clavicles (HP:0000890)1.54244956
155Metatarsus adductus (HP:0001840)1.54084040
156Abnormality of the umbilical cord (HP:0010881)1.53353333
157Cortical dysplasia (HP:0002539)1.52800190
158Scapular winging (HP:0003691)1.51226790
159Abnormalities of placenta or umbilical cord (HP:0001194)1.50883503
160Prominent metopic ridge (HP:0005487)1.50857273
161Medulloblastoma (HP:0002885)1.49965416
162Abnormal biliary tract morphology (HP:0012440)1.49371307
163Proximal amyotrophy (HP:0007126)1.49329371
164Premature rupture of membranes (HP:0001788)1.47143713
165Cutaneous melanoma (HP:0012056)1.46854408
166Ulnar deviation of the wrist (HP:0003049)1.46751564
167Dilated cardiomyopathy (HP:0001644)1.46321640
168Neoplasm of the peripheral nervous system (HP:0100007)1.45803959
169Frequent falls (HP:0002359)1.44545389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.71333248
2BCKDK3.64407436
3PDK43.60129550
4PDK33.60129550
5NEK13.58560335
6PKN23.55288704
7SRPK12.97693989
8PBK2.77708301
9LATS12.42578324
10ERBB32.40762747
11MST42.40480805
12EIF2AK32.35758379
13BUB12.23502506
14TRIM282.13018111
15EIF2AK12.08303972
16LATS21.97811873
17STK38L1.93158116
18MAP2K41.93031562
19TAOK21.87865483
20TTN1.84091761
21PDK21.78583908
22FLT31.71560829
23CDK121.66137267
24MAP3K41.62239948
25MKNK11.61758683
26MAP3K51.61625335
27BCR1.57734151
28OBSCN1.49552730
29SCYL21.42291798
30MKNK21.36157959
31FRK1.33651696
32WNK31.33174672
33PRKD31.27877531
34LIMK11.27280861
35PDGFRA1.24180436
36TAF11.22396113
37INSRR1.22184960
38KSR11.20604120
39SIK11.19565641
40MAP3K121.19482968
41NEK21.19408235
42RPS6KA41.19221893
43NEK91.18938292
44AKT31.18296232
45STK381.11441965
46CDC71.11026547
47BRD41.09716910
48LMTK21.07847573
49CSNK1G11.06100263
50PHKG21.04254192
51PHKG11.04254192
52KSR21.02459824
53WEE11.00210823
54PTK60.99971905
55PINK10.98645173
56CCNB10.98471075
57PRKAA10.97206568
58WNK40.94398512
59PASK0.92965209
60CAMK1D0.92034701
61TTK0.89838028
62CSNK1G30.89793049
63RPS6KB20.89649100
64MAP3K60.86481373
65RIPK10.84931247
66STK240.84885835
67PAK60.84378519
68STK30.83892316
69PAK30.82585273
70ERN10.82516910
71RET0.82244586
72PNCK0.81978677
73MAP3K100.81926123
74CSNK1G20.80710799
75BRSK20.80555081
76AURKB0.79646199
77MOS0.77426677
78VRK20.77009522
79SGK30.76347968
80MAP2K70.75198310
81MAP2K60.75009728
82MTOR0.74919665
83FER0.74544518
84CSNK1A1L0.74520128
85ERBB40.74092322
86CDK60.69515806
87SGK20.69169048
88MAPK110.69140664
89CHEK10.68988088
90DMPK0.68692423
91CDK40.67157747
92MST1R0.66873253
93ACVR1B0.66126320
94MAP3K70.64403215
95ATR0.64215267
96ARAF0.63830033
97TYRO30.63209644
98FGFR40.62341992
99STK160.62234180
100ATM0.61881569
101CDK190.61322883
102EIF2AK20.61322573
103PLK40.61209181
104CDK70.60698271
105CHEK20.60325623
106VRK10.59999543
107WNK10.59387848
108AKT20.57924727
109PLK20.57744017
110MET0.57654975
111CAMK2D0.57474563
112FGFR10.57017356
113CAMKK10.56968290
114ALK0.56371378
115CDK140.55348367
116CDK180.54120304
117STK390.53363831
118MAP2K30.53266524
119PIM20.52477254
120PAK20.51945016
121TSSK60.51324718
122RPS6KB10.51307314
123PDPK10.50742042
124PLK30.49560986
125AURKA0.49350262
126MAP2K10.49045290
127MAP3K90.48933421
128TESK10.48503313
129ZAK0.48075049
130STK40.47468482
131PRKAA20.45581610
132CDK150.44951910
133ICK0.44314454
134DAPK20.43870284
135DAPK10.43533608
136CSNK1E0.43480868
137MAP3K80.43049745
138PDK10.42933083
139MINK10.42579023
140CDK11A0.42571788
141BRSK10.42336511
142PIK3CG0.41485513
143ILK0.41185257
144CAMK1G0.40599147
145CAMK2G0.40319622
146PLK10.39907407
147PTK20.39891569
148TRPM70.39308011
149NME20.38549766
150* CDK10.37905411
151SGK2230.37322275
152SGK4940.37322275
153MAP3K20.37289313
154EEF2K0.37032200
155MAP3K110.36244200
156PRKACG0.36220484
157PAK40.36181648
158MAPKAPK30.35667457
159DYRK1B0.33902229
160TAOK10.33720667

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.00586083
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.93142712
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.57522324
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.12531003
5Nitrogen metabolism_Homo sapiens_hsa009103.05609793
6Propanoate metabolism_Homo sapiens_hsa006402.97130216
7Fatty acid degradation_Homo sapiens_hsa000712.84382349
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74228398
9Arginine biosynthesis_Homo sapiens_hsa002202.69620633
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.55307901
11Butanoate metabolism_Homo sapiens_hsa006502.30230874
12Carbon metabolism_Homo sapiens_hsa012002.26553049
13Pyruvate metabolism_Homo sapiens_hsa006202.26368747
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.22744996
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19021605
16Fatty acid metabolism_Homo sapiens_hsa012122.17572818
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17427498
18Tryptophan metabolism_Homo sapiens_hsa003802.12620464
19Mismatch repair_Homo sapiens_hsa034301.97572683
20DNA replication_Homo sapiens_hsa030301.96444348
21Protein export_Homo sapiens_hsa030601.95612958
22Biosynthesis of amino acids_Homo sapiens_hsa012301.93636973
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84517641
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84108195
25Non-homologous end-joining_Homo sapiens_hsa034501.78117630
26Selenocompound metabolism_Homo sapiens_hsa004501.73923484
27Spliceosome_Homo sapiens_hsa030401.68159551
28PPAR signaling pathway_Homo sapiens_hsa033201.65439733
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.65354725
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62675580
31Cell cycle_Homo sapiens_hsa041101.62335875
32mRNA surveillance pathway_Homo sapiens_hsa030151.56295818
33Nucleotide excision repair_Homo sapiens_hsa034201.56291320
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49033749
35Proteasome_Homo sapiens_hsa030501.45634860
36beta-Alanine metabolism_Homo sapiens_hsa004101.45119742
37Peroxisome_Homo sapiens_hsa041461.41687938
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41450739
39Circadian rhythm_Homo sapiens_hsa047101.35309002
40Steroid biosynthesis_Homo sapiens_hsa001001.29271640
41Basal transcription factors_Homo sapiens_hsa030221.29224217
42Phenylalanine metabolism_Homo sapiens_hsa003601.27011408
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25478076
44Base excision repair_Homo sapiens_hsa034101.24891443
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23834427
46RNA degradation_Homo sapiens_hsa030181.23371833
47Bile secretion_Homo sapiens_hsa049761.22433765
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21050468
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.18784253
50Starch and sucrose metabolism_Homo sapiens_hsa005001.17543241
51Vitamin B6 metabolism_Homo sapiens_hsa007501.12750697
52Lysine degradation_Homo sapiens_hsa003101.11825660
53Complement and coagulation cascades_Homo sapiens_hsa046101.09514844
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.06812042
55RNA polymerase_Homo sapiens_hsa030201.00633025
56Glucagon signaling pathway_Homo sapiens_hsa049221.00070555
57Pyrimidine metabolism_Homo sapiens_hsa002400.95886322
58Fat digestion and absorption_Homo sapiens_hsa049750.94844752
59Tyrosine metabolism_Homo sapiens_hsa003500.91135713
60Hippo signaling pathway_Homo sapiens_hsa043900.89889982
61Purine metabolism_Homo sapiens_hsa002300.89498844
62One carbon pool by folate_Homo sapiens_hsa006700.89069166
63Folate biosynthesis_Homo sapiens_hsa007900.88678962
64Adherens junction_Homo sapiens_hsa045200.88400576
65Insulin resistance_Homo sapiens_hsa049310.88346604
66Tight junction_Homo sapiens_hsa045300.87214390
67Sulfur metabolism_Homo sapiens_hsa009200.87093580
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84623320
69Arginine and proline metabolism_Homo sapiens_hsa003300.84487588
70Fanconi anemia pathway_Homo sapiens_hsa034600.79943227
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.79592328
72p53 signaling pathway_Homo sapiens_hsa041150.76344467
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74754800
74Fatty acid biosynthesis_Homo sapiens_hsa000610.73203512
75AMPK signaling pathway_Homo sapiens_hsa041520.72946716
76Sulfur relay system_Homo sapiens_hsa041220.71388824
77Caffeine metabolism_Homo sapiens_hsa002320.70979430
78Homologous recombination_Homo sapiens_hsa034400.70047239
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69947934
80Insulin signaling pathway_Homo sapiens_hsa049100.69560656
81TGF-beta signaling pathway_Homo sapiens_hsa043500.67581802
82Chemical carcinogenesis_Homo sapiens_hsa052040.66482725
83Pentose phosphate pathway_Homo sapiens_hsa000300.65603091
84mTOR signaling pathway_Homo sapiens_hsa041500.65277615
85Fructose and mannose metabolism_Homo sapiens_hsa000510.61280667
86Glycerolipid metabolism_Homo sapiens_hsa005610.60919093
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.60627890
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59655199
89N-Glycan biosynthesis_Homo sapiens_hsa005100.58262881
90Histidine metabolism_Homo sapiens_hsa003400.58203094
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.54873063
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.54287907
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54100668
94Vibrio cholerae infection_Homo sapiens_hsa051100.52567476
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52459229
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51738025
97Retinol metabolism_Homo sapiens_hsa008300.50895297
98Wnt signaling pathway_Homo sapiens_hsa043100.49599712
99Huntingtons disease_Homo sapiens_hsa050160.49135308
100ABC transporters_Homo sapiens_hsa020100.47215421
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46773094
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46360347
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43603637
104Fatty acid elongation_Homo sapiens_hsa000620.42663346
105Alcoholism_Homo sapiens_hsa050340.42302058
106Regulation of autophagy_Homo sapiens_hsa041400.41921260
107Cardiac muscle contraction_Homo sapiens_hsa042600.41485445
108Galactose metabolism_Homo sapiens_hsa000520.39172884
109Colorectal cancer_Homo sapiens_hsa052100.38338896
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35514483
111Alzheimers disease_Homo sapiens_hsa050100.35116321
112Prostate cancer_Homo sapiens_hsa052150.34284352
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33762391
114Metabolic pathways_Homo sapiens_hsa011000.33662184
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32508901
116Vitamin digestion and absorption_Homo sapiens_hsa049770.31737076
117Type II diabetes mellitus_Homo sapiens_hsa049300.29516249
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27612411
119Dilated cardiomyopathy_Homo sapiens_hsa054140.27547113
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27283880
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26164161
122RNA transport_Homo sapiens_hsa030130.25550429
123Endometrial cancer_Homo sapiens_hsa052130.24856737
124Glutathione metabolism_Homo sapiens_hsa004800.23742069
125Prion diseases_Homo sapiens_hsa050200.23460318
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21557908
127Thyroid cancer_Homo sapiens_hsa052160.18999437
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18984765
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18948281
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18419709
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18078600
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17736449
133Insulin secretion_Homo sapiens_hsa049110.17421412
134Oocyte meiosis_Homo sapiens_hsa041140.17410754
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15317432
136Parkinsons disease_Homo sapiens_hsa050120.14354478
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12976803
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12198721
139Bladder cancer_Homo sapiens_hsa052190.12122544
140FoxO signaling pathway_Homo sapiens_hsa040680.11594747

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