GRTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.30745189
2central nervous system myelination (GO:0022010)9.30745189
3fatty acid elongation (GO:0030497)6.44544908
4growth hormone receptor signaling pathway (GO:0060396)6.05038987
5cellular response to growth hormone stimulus (GO:0071378)5.37943206
6myelination (GO:0042552)4.90568093
7axon ensheathment (GO:0008366)4.89238667
8ensheathment of neurons (GO:0007272)4.89238667
9long-chain fatty acid biosynthetic process (GO:0042759)4.50886752
10photoreceptor cell differentiation (GO:0046530)4.47855575
11eye photoreceptor cell differentiation (GO:0001754)4.47855575
12cholesterol biosynthetic process (GO:0006695)4.21079488
13import into cell (GO:0098657)4.18869417
14positive regulation of cellular amine metabolic process (GO:0033240)3.91100144
15Rap protein signal transduction (GO:0032486)3.89225772
16nuclear envelope reassembly (GO:0031468)3.86331989
17mitotic nuclear envelope reassembly (GO:0007084)3.86331989
18water-soluble vitamin biosynthetic process (GO:0042364)3.82135869
19amino acid import (GO:0043090)3.76112093
20preassembly of GPI anchor in ER membrane (GO:0016254)3.73380555
21serine family amino acid catabolic process (GO:0009071)3.71581178
22DNA replication checkpoint (GO:0000076)3.67150137
23sterol biosynthetic process (GO:0016126)3.64677230
24negative regulation of JAK-STAT cascade (GO:0046426)3.64258432
25GPI anchor biosynthetic process (GO:0006506)3.60292621
26glycerophospholipid catabolic process (GO:0046475)3.58914690
27myelin maintenance (GO:0043217)3.56769662
28response to redox state (GO:0051775)3.56178217
29positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.53953721
30negative regulation of neurotransmitter secretion (GO:0046929)3.53537408
31glycosylceramide metabolic process (GO:0006677)3.44073999
32GPI anchor metabolic process (GO:0006505)3.41697174
33establishment of mitochondrion localization (GO:0051654)3.41260616
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36540608
35L-phenylalanine catabolic process (GO:0006559)3.36540608
36oligodendrocyte differentiation (GO:0048709)3.36487397
37serine family amino acid biosynthetic process (GO:0009070)3.35901611
38phosphatidylserine acyl-chain remodeling (GO:0036150)3.35698239
39positive regulation of prostaglandin secretion (GO:0032308)3.34237655
40drug catabolic process (GO:0042737)3.32090742
41superoxide anion generation (GO:0042554)3.29098621
42glycine metabolic process (GO:0006544)3.29054585
43negative regulation of execution phase of apoptosis (GO:1900118)3.25025203
44chromatin remodeling at centromere (GO:0031055)3.22903589
45DNA double-strand break processing (GO:0000729)3.21455075
46serine family amino acid metabolic process (GO:0009069)3.20633324
47regulation of rhodopsin mediated signaling pathway (GO:0022400)3.20446496
48exogenous drug catabolic process (GO:0042738)3.20293060
49nucleotide transmembrane transport (GO:1901679)3.19279575
50cysteine metabolic process (GO:0006534)3.19259094
51amyloid precursor protein metabolic process (GO:0042982)3.19168701
52response to growth hormone (GO:0060416)3.18664741
53positive regulation of protein autophosphorylation (GO:0031954)3.18224405
54ribosomal small subunit biogenesis (GO:0042274)3.17894566
55arginine metabolic process (GO:0006525)3.16107030
56sphingoid metabolic process (GO:0046519)3.15090203
57rhodopsin mediated signaling pathway (GO:0016056)3.14051540
58diol metabolic process (GO:0034311)3.13321848
59response to methylmercury (GO:0051597)3.12703007
60magnesium ion transport (GO:0015693)3.11979114
61eosinophil chemotaxis (GO:0048245)3.11059457
62respiratory chain complex IV assembly (GO:0008535)3.10713095
63glyoxylate metabolic process (GO:0046487)3.10447167
64protein palmitoylation (GO:0018345)3.09608544
65regulation of mitotic spindle checkpoint (GO:1903504)3.07808504
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07808504
67amyloid precursor protein catabolic process (GO:0042987)3.07611601
68regulation of gene silencing by RNA (GO:0060966)3.07006834
69regulation of posttranscriptional gene silencing (GO:0060147)3.07006834
70regulation of gene silencing by miRNA (GO:0060964)3.07006834
71amino acid salvage (GO:0043102)3.06980337
72L-methionine salvage (GO:0071267)3.06980337
73L-methionine biosynthetic process (GO:0071265)3.06980337
74glucuronate metabolic process (GO:0019585)3.04896168
75uronic acid metabolic process (GO:0006063)3.04896168
76isoprenoid biosynthetic process (GO:0008299)3.04159088
77CENP-A containing nucleosome assembly (GO:0034080)3.04088885
78negative regulation of neurotransmitter transport (GO:0051589)3.02877550
79heme transport (GO:0015886)3.01098801
80presynaptic membrane assembly (GO:0097105)2.99254107
81positive regulation of cell fate commitment (GO:0010455)2.96731105
82cellular glucuronidation (GO:0052695)2.95877599
83epoxygenase P450 pathway (GO:0019373)2.95117149
84response to lead ion (GO:0010288)2.94372551
85photoreceptor cell maintenance (GO:0045494)2.93766523
86protein neddylation (GO:0045116)2.93184744
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91635108
88ribosomal large subunit biogenesis (GO:0042273)2.90337283
89pseudouridine synthesis (GO:0001522)2.89824007
90presynaptic membrane organization (GO:0097090)2.88730768
91viral transcription (GO:0019083)2.87168199
92substantia nigra development (GO:0021762)2.87029633
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85820282
94L-phenylalanine metabolic process (GO:0006558)2.85820282
95negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85449732
96positive regulation of icosanoid secretion (GO:0032305)2.83887653
97base-excision repair, AP site formation (GO:0006285)2.82821631
98homocysteine metabolic process (GO:0050667)2.82389163
99vitamin biosynthetic process (GO:0009110)2.81859396
100adenosine receptor signaling pathway (GO:0001973)2.81078544
101L-serine metabolic process (GO:0006563)2.80516206
102sphingomyelin metabolic process (GO:0006684)2.80273695
103cotranslational protein targeting to membrane (GO:0006613)2.79651770
104L-amino acid import (GO:0043092)2.78735019
105behavioral response to nicotine (GO:0035095)2.78368923
106eosinophil migration (GO:0072677)2.77510125
107protein targeting to ER (GO:0045047)2.76435043
108somatic hypermutation of immunoglobulin genes (GO:0016446)2.76227145
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76227145
110negative regulation of cholesterol transport (GO:0032375)2.75587715
111negative regulation of sterol transport (GO:0032372)2.75587715
112leukocyte migration involved in inflammatory response (GO:0002523)2.74718057
113regulation of nuclear cell cycle DNA replication (GO:0033262)2.74224218
114peptidyl-cysteine modification (GO:0018198)2.73982176
115oxidative demethylation (GO:0070989)2.73959845
116regulation of prostaglandin secretion (GO:0032306)2.73794932
117establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73734891
118translational termination (GO:0006415)2.73041494
119DNA strand renaturation (GO:0000733)2.72427813
120mannosylation (GO:0097502)2.71377097
121phosphatidylserine metabolic process (GO:0006658)2.71235237
122positive regulation of fatty acid transport (GO:2000193)2.70956255
123S-adenosylmethionine metabolic process (GO:0046500)2.70239798
124nucleotide transport (GO:0006862)2.69957526
125DNA replication-dependent nucleosome assembly (GO:0006335)2.69707906
126DNA replication-dependent nucleosome organization (GO:0034723)2.69707906
127proteasome assembly (GO:0043248)2.68856949
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.67781773
129response to lipoprotein particle (GO:0055094)2.67716314
130creatine metabolic process (GO:0006600)2.67136817
131positive regulation of chemokine secretion (GO:0090197)2.66961251
132C-terminal protein lipidation (GO:0006501)2.66741736
133glucosamine-containing compound catabolic process (GO:1901072)2.66280656
134DNA catabolic process, exonucleolytic (GO:0000738)2.66059527
135respiratory burst (GO:0045730)2.66050876
136protein localization to endoplasmic reticulum (GO:0070972)2.65843772
137phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.65187652
138asymmetric protein localization (GO:0008105)2.64949269
139positive regulation of oligodendrocyte differentiation (GO:0048714)2.64797970
140axon development (GO:0061564)2.64669611
141GTP biosynthetic process (GO:0006183)2.64665396
142histone exchange (GO:0043486)2.64264973
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.64029236
144termination of RNA polymerase III transcription (GO:0006386)2.64029236
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.63620365
146negative regulation of macroautophagy (GO:0016242)2.63466514
147drug metabolic process (GO:0017144)2.60439984
148very long-chain fatty acid metabolic process (GO:0000038)2.59691233
149high-density lipoprotein particle remodeling (GO:0034375)2.59558752
150mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59258423
151quinone biosynthetic process (GO:1901663)2.58540475
152L-alpha-amino acid transmembrane transport (GO:1902475)2.57829284
153aromatic amino acid family catabolic process (GO:0009074)2.56580963
154replication fork processing (GO:0031297)2.56563321
155lysine metabolic process (GO:0006553)2.56071079
156lysine catabolic process (GO:0006554)2.56071079
157rRNA modification (GO:0000154)2.52345859
158peptidyl-histidine modification (GO:0018202)2.51957016
159cytochrome complex assembly (GO:0017004)2.50591024
160mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49749145
161NADH dehydrogenase complex assembly (GO:0010257)2.46873593
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46873593
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.46873593
164regulation of bile acid biosynthetic process (GO:0070857)2.44339765
165nucleotide-sugar biosynthetic process (GO:0009226)2.42223456
166aldehyde catabolic process (GO:0046185)2.41862889
167DNA replication-independent nucleosome assembly (GO:0006336)2.41507532
168DNA replication-independent nucleosome organization (GO:0034724)2.41507532
169DNA strand elongation involved in DNA replication (GO:0006271)2.40413549
170alpha-amino acid catabolic process (GO:1901606)2.39106655
171protein complex biogenesis (GO:0070271)2.39019710
172regulation of meiosis I (GO:0060631)2.38574167
173telomere maintenance via semi-conservative replication (GO:0032201)2.38403413
174response to nitrosative stress (GO:0051409)2.36588399
175aspartate family amino acid catabolic process (GO:0009068)2.36423369
176blood coagulation, intrinsic pathway (GO:0007597)2.36134202
177mitochondrial respiratory chain complex assembly (GO:0033108)2.35880838
178proline metabolic process (GO:0006560)2.35199718
179sulfur amino acid catabolic process (GO:0000098)2.32796762
180regulation of cholesterol esterification (GO:0010872)2.31076921
181chaperone-mediated protein transport (GO:0072321)2.29806730
182protein-cofactor linkage (GO:0018065)2.28925301
183establishment of protein localization to mitochondrial membrane (GO:0090151)2.28629589
184L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.27861562
185ATP synthesis coupled proton transport (GO:0015986)2.26885502
186energy coupled proton transport, down electrochemical gradient (GO:0015985)2.26885502
187DNA strand elongation (GO:0022616)2.26760359
188piRNA metabolic process (GO:0034587)2.25902987
189nucleoside transmembrane transport (GO:1901642)2.25815593
190positive regulation of histone H3-K4 methylation (GO:0051571)2.25794942
191meiotic chromosome segregation (GO:0045132)2.25365847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.54659344
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.18024804
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.49472201
4E2F7_22180533_ChIP-Seq_HELA_Human3.46854331
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41691316
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.35116422
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.35116422
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.35116422
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65128002
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55539733
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.54339946
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41180597
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.25037261
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21488139
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.13224529
16ZNF274_21170338_ChIP-Seq_K562_Hela2.10571512
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06905930
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03050734
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02838421
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97873927
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94720911
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94399924
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83217062
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82069184
25ER_23166858_ChIP-Seq_MCF-7_Human1.81902348
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74661500
27P300_18555785_Chip-Seq_ESCs_Mouse1.72288051
28MYC_18940864_ChIP-ChIP_HL60_Human1.72112142
29FOXP3_21729870_ChIP-Seq_TREG_Human1.70515912
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67253346
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66094248
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65703468
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.65354272
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63784874
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.63221257
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59252099
37VDR_22108803_ChIP-Seq_LS180_Human1.59024691
38VDR_23849224_ChIP-Seq_CD4+_Human1.57693786
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57341904
40GABP_19822575_ChIP-Seq_HepG2_Human1.56406322
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55969838
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.55641050
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.55119071
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54499968
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53645962
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52539764
47ELK1_19687146_ChIP-ChIP_HELA_Human1.52253466
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52056714
49TAF15_26573619_Chip-Seq_HEK293_Human1.51707971
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51201933
51DCP1A_22483619_ChIP-Seq_HELA_Human1.50913342
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.48912974
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47186798
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.46897134
55RUNX1_27457419_Chip-Seq_LIVER_Mouse1.46675456
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46591536
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46021344
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45704714
59SMAD1_18555785_Chip-Seq_ESCs_Mouse1.44892164
60IRF1_19129219_ChIP-ChIP_H3396_Human1.43737134
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.43441004
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.42762023
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.42613372
64XRN2_22483619_ChIP-Seq_HELA_Human1.42071052
65P53_22387025_ChIP-Seq_ESCs_Mouse1.40767917
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.39982693
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.39128090
68TTF2_22483619_ChIP-Seq_HELA_Human1.38630884
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.37688044
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.37080400
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.36971560
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36088285
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35164170
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35164170
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.34442108
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33887361
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.31688794
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.31446602
79* NANOG_20526341_ChIP-Seq_ESCs_Human1.30162435
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.29368416
81GABP_17652178_ChIP-ChIP_JURKAT_Human1.29316231
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.29208604
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28782913
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.28696310
85EWS_26573619_Chip-Seq_HEK293_Human1.28394292
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27558649
87FUS_26573619_Chip-Seq_HEK293_Human1.26991610
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26769905
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26619069
90* RXR_22158963_ChIP-Seq_LIVER_Mouse1.25404923
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24432348
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24216167
93IGF1R_20145208_ChIP-Seq_DFB_Human1.23346458
94AR_20517297_ChIP-Seq_VCAP_Human1.23171203
95* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22874996
96HTT_18923047_ChIP-ChIP_STHdh_Human1.21306115
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19697765
98EOMES_21245162_ChIP-Seq_HESCs_Human1.19277787
99GBX2_23144817_ChIP-Seq_PC3_Human1.19243649
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18893307
101PU1_27457419_Chip-Seq_LIVER_Mouse1.18583463
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18266964
103GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16371206
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16072156
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15922330
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14680246
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14325194
108ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14042367
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13589883
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13137781
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12972792
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.12340852
113TP53_22573176_ChIP-Seq_HFKS_Human1.12184010
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11810554
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11684105
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11124349
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11008954
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.10052525
119SOX17_20123909_ChIP-Seq_XEN_Mouse1.09862433
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09447530
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08548969
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08008782
123* HOXB7_26014856_ChIP-Seq_BT474_Human1.07547282
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07251696
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.07191942
126FOXA1_25329375_ChIP-Seq_VCAP_Human1.07027705
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07027705
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04862409
129KDM5A_27292631_Chip-Seq_BREAST_Human1.04839536
130YY1_21170310_ChIP-Seq_MESCs_Mouse1.03490275
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03415615
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.02951687
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.02897467
134ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02386239
135ERA_21632823_ChIP-Seq_H3396_Human1.02019573
136PHF8_20622853_ChIP-Seq_HELA_Human1.01662145
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.01318155
138GATA4_25053715_ChIP-Seq_YYC3_Human1.00966894
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00911916
140CBP_21632823_ChIP-Seq_H3396_Human1.00286759
141P53_21459846_ChIP-Seq_SAOS-2_Human1.00163590
142KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99892827
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99516181
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98002456
145SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97802822
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96951719
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96918749
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.96416828
149STAT1_20625510_ChIP-Seq_HELA_Human0.96193308
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95530804
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95228108
152POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94775719
153* NCOR_22424771_ChIP-Seq_293T_Human0.94775613
154POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94343831
155GATA6_21074721_ChIP-Seq_CACO-2_Human0.93631995
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93339276
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93336206
158BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93219760
159CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92969821
160AR_21572438_ChIP-Seq_LNCaP_Human0.91841478
161NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91619792
162NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91271218
163OCT4_20526341_ChIP-Seq_ESCs_Human0.88993432
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.88898505
165MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88806368
166GATA6_25053715_ChIP-Seq_YYC3_Human0.88627317
167AR_21909140_ChIP-Seq_LNCAP_Human0.88553904
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.87530458
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87523614
170P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87314665
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87046205
172SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86879010
173AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86868578
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86489435
175* NANOG_19829295_ChIP-Seq_ESCs_Human0.85792380
176HNF4A_19822575_ChIP-Seq_HepG2_Human0.85446569
177GATA1_26923725_Chip-Seq_HPCs_Mouse0.85333169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system7.11488110
2MP0009379_abnormal_foot_pigmentation6.12240317
3MP0003303_peritoneal_inflammation4.12145687
4MP0003136_yellow_coat_color3.99220302
5MP0003718_maternal_effect3.54508431
6MP0000920_abnormal_myelination3.45508356
7MP0005360_urolithiasis3.30795436
8MP0003011_delayed_dark_adaptation3.21050094
9MP0005365_abnormal_bile_salt3.14274861
10MP0003693_abnormal_embryo_hatching3.09545208
11MP0005085_abnormal_gallbladder_physiolo3.02180146
12MP0005409_darkened_coat_color2.97487618
13MP0003950_abnormal_plasma_membrane2.79260621
14MP0002254_reproductive_system_inflammat2.67891109
15MP0003690_abnormal_glial_cell2.63758900
16MP0004381_abnormal_hair_follicle2.45676059
17MP0008877_abnormal_DNA_methylation2.37166166
18MP0004043_abnormal_pH_regulation2.32587781
19MP0008058_abnormal_DNA_repair2.31621925
20MP0001986_abnormal_taste_sensitivity2.21696967
21MP0005551_abnormal_eye_electrophysiolog2.19201840
22MP0001666_abnormal_nutrient_absorption2.17905010
23MP0004185_abnormal_adipocyte_glucose2.14398094
24MP0003195_calcinosis2.11457753
25MP0010094_abnormal_chromosome_stability2.00264206
26MP0000613_abnormal_salivary_gland2.00221717
27MP0003941_abnormal_skin_development1.90146843
28MP0000462_abnormal_digestive_system1.86813261
29MP0005083_abnormal_biliary_tract1.81781294
30MP0004957_abnormal_blastocyst_morpholog1.79169642
31MP0004742_abnormal_vestibular_system1.74221544
32MP0005410_abnormal_fertilization1.73917940
33MP0005423_abnormal_somatic_nervous1.73233606
34MP0001485_abnormal_pinna_reflex1.67945576
35MP0003111_abnormal_nucleus_morphology1.65785688
36MP0001968_abnormal_touch/_nociception1.61946462
37MP0010329_abnormal_lipoprotein_level1.57782191
38MP0008872_abnormal_physiological_respon1.56101269
39MP0005451_abnormal_body_composition1.54753007
40MP0005058_abnormal_lysosome_morphology1.45347473
41MP0001293_anophthalmia1.44274003
42MP0003880_abnormal_central_pattern1.42401939
43MP0002938_white_spotting1.39813962
44MP0003724_increased_susceptibility_to1.39785263
45MP0004142_abnormal_muscle_tone1.39340859
46MP0001905_abnormal_dopamine_level1.39055248
47MP0001542_abnormal_bone_strength1.37866098
48MP0005253_abnormal_eye_physiology1.35740148
49MP0002736_abnormal_nociception_after1.32605083
50MP0004147_increased_porphyrin_level1.30606931
51MP0009697_abnormal_copulation1.29835951
52MP0004133_heterotaxia1.29566760
53MP0003890_abnormal_embryonic-extraembry1.28176099
54MP0002229_neurodegeneration1.27470254
55MP0003119_abnormal_digestive_system1.25605265
56MP0005171_absent_coat_pigmentation1.24503890
57MP0005395_other_phenotype1.23801553
58MP0005636_abnormal_mineral_homeostasis1.21363519
59MP0003252_abnormal_bile_duct1.20575105
60MP0000647_abnormal_sebaceous_gland1.20089218
61MP0005646_abnormal_pituitary_gland1.19029337
62MP0006072_abnormal_retinal_apoptosis1.18875867
63MP0002876_abnormal_thyroid_physiology1.18432989
64MP0000383_abnormal_hair_follicle1.18117019
65MP0001346_abnormal_lacrimal_gland1.18000217
66MP0008789_abnormal_olfactory_epithelium1.14014228
67MP0003878_abnormal_ear_physiology1.11458071
68MP0005377_hearing/vestibular/ear_phenot1.11458071
69MP0003828_pulmonary_edema1.11418558
70MP0000566_synostosis1.11095337
71MP0005381_digestive/alimentary_phenotyp1.10138161
72MP0003186_abnormal_redox_activity1.10136354
73MP0002160_abnormal_reproductive_system1.09706403
74MP0005195_abnormal_posterior_eye1.09315527
75MP0003300_gastrointestinal_ulcer1.09103236
76MP0000467_abnormal_esophagus_morphology1.08055731
77MP0003077_abnormal_cell_cycle1.06768911
78MP0002098_abnormal_vibrissa_morphology1.06090166
79MP0008260_abnormal_autophagy1.05329518
80MP0005379_endocrine/exocrine_gland_phen1.04599142
81MP0001188_hyperpigmentation1.04231471
82MP0010030_abnormal_orbit_morphology1.03751538
83MP0001929_abnormal_gametogenesis1.03289082
84MP0003634_abnormal_glial_cell1.03285454
85MP0005220_abnormal_exocrine_pancreas1.02331646
86MP0002102_abnormal_ear_morphology1.01896644
87MP0003329_amyloid_beta_deposits1.00955888
88MP0004885_abnormal_endolymph1.00760477
89MP0003121_genomic_imprinting0.99431363
90MP0006036_abnormal_mitochondrial_physio0.99387402
91MP0003567_abnormal_fetal_cardiomyocyte0.99020905
92MP0002148_abnormal_hypersensitivity_rea0.98671714
93MP0002909_abnormal_adrenal_gland0.98536400
94MP0002210_abnormal_sex_determination0.97515841
95MP0001851_eye_inflammation0.96175634
96MP0003938_abnormal_ear_development0.95469957
97MP0000653_abnormal_sex_gland0.94788716
98MP0008932_abnormal_embryonic_tissue0.90999080
99MP0002638_abnormal_pupillary_reflex0.90659020
100MP0004019_abnormal_vitamin_homeostasis0.90638564
101MP0006035_abnormal_mitochondrial_morpho0.90144967
102MP0001486_abnormal_startle_reflex0.89554884
103MP0001145_abnormal_male_reproductive0.88650183
104MP0006082_CNS_inflammation0.88043414
105MP0000604_amyloidosis0.87854294
106MP0002277_abnormal_respiratory_mucosa0.87477210
107MP0003787_abnormal_imprinting0.87452050
108MP0001243_abnormal_dermal_layer0.86813935
109MP0003786_premature_aging0.85927495
110MP0000015_abnormal_ear_pigmentation0.84744594
111MP0002796_impaired_skin_barrier0.84173393
112MP0009840_abnormal_foam_cell0.83179349
113MP0004264_abnormal_extraembryonic_tissu0.82712124
114MP0005394_taste/olfaction_phenotype0.82309082
115MP0005499_abnormal_olfactory_system0.82309082
116MP0010678_abnormal_skin_adnexa0.80029243
117MP0008007_abnormal_cellular_replicative0.78867481
118MP0005084_abnormal_gallbladder_morpholo0.78812297
119MP0003453_abnormal_keratinocyte_physiol0.78759519
120MP0003806_abnormal_nucleotide_metabolis0.78119811
121MP0000778_abnormal_nervous_system0.78046052
122MP0001661_extended_life_span0.77881488
123MP0002752_abnormal_somatic_nervous0.77642477
124MP0009643_abnormal_urine_homeostasis0.76690743
125MP0001529_abnormal_vocalization0.76470041
126MP0005389_reproductive_system_phenotype0.76245528
127MP0006292_abnormal_olfactory_placode0.76159822
128MP0003122_maternal_imprinting0.75842330
129MP0005332_abnormal_amino_acid0.75679755
130MP0005666_abnormal_adipose_tissue0.75327493
131MP0000579_abnormal_nail_morphology0.75144453
132MP0000631_abnormal_neuroendocrine_gland0.74976557
133MP0004270_analgesia0.74920940
134MP0009765_abnormal_xenobiotic_induced0.74758170
135MP0003632_abnormal_nervous_system0.74132441
136MP0008057_abnormal_DNA_replication0.73686004
137MP0003879_abnormal_hair_cell0.73551895
138MP0001664_abnormal_digestion0.72678967
139MP0003699_abnormal_female_reproductive0.72466091
140MP0002118_abnormal_lipid_homeostasis0.71676199
141MP0003315_abnormal_perineum_morphology0.71383714
142MP0003123_paternal_imprinting0.70387236
143MP0003868_abnormal_feces_composition0.69554382
144MP0005174_abnormal_tail_pigmentation0.69545483
145MP0003937_abnormal_limbs/digits/tail_de0.69166250
146MP0001324_abnormal_eye_pigmentation0.68989692
147MP0000026_abnormal_inner_ear0.68454786
148MP0003638_abnormal_response/metabolism_0.68374449
149MP0000762_abnormal_tongue_morphology0.68260370
150MP0001756_abnormal_urination0.68002549
151MP0009672_abnormal_birth_weight0.67906537
152MP0001730_embryonic_growth_arrest0.67550271
153MP0001663_abnormal_digestive_system0.66922156
154MP0005375_adipose_tissue_phenotype0.66641830
155MP0001963_abnormal_hearing_physiology0.65874117
156MP0000372_irregular_coat_pigmentation0.63842851
157MP0000470_abnormal_stomach_morphology0.62533410
158MP0005391_vision/eye_phenotype0.62196344
159MP0001727_abnormal_embryo_implantation0.61278979
160MP0002163_abnormal_gland_morphology0.61190880
161MP0008875_abnormal_xenobiotic_pharmacok0.61102427
162MP0009250_abnormal_appendicular_skeleto0.61078318
163MP0001299_abnormal_eye_distance/0.60974774
164MP0001764_abnormal_homeostasis0.60736937
165MP0001348_abnormal_lacrimal_gland0.59580370
166MP0002139_abnormal_hepatobiliary_system0.59209884
167MP0001765_abnormal_ion_homeostasis0.57573936
168MP0003698_abnormal_male_reproductive0.57192565
169MP0005501_abnormal_skin_physiology0.56964416
170MP0005387_immune_system_phenotype0.56342190
171MP0001790_abnormal_immune_system0.56342190

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.28755846
2Parakeratosis (HP:0001036)4.92260305
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.56786014
4Neurofibrillary tangles (HP:0002185)4.25626629
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.77375606
6Hyperglycinuria (HP:0003108)3.65572782
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.65296041
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.65296041
9Abnormal pupillary function (HP:0007686)3.62159102
10Abnormality of glycine metabolism (HP:0010895)3.61900548
11Abnormality of serine family amino acid metabolism (HP:0010894)3.61900548
12Hyperglycinemia (HP:0002154)3.60026332
13Stomatitis (HP:0010280)3.52499175
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.49383170
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44739491
16Abnormal hemoglobin (HP:0011902)3.24190595
17Congenital sensorineural hearing impairment (HP:0008527)3.21867436
18Abnormality of the labia minora (HP:0012880)3.17812604
19Prolonged partial thromboplastin time (HP:0003645)2.98886740
20Hypobetalipoproteinemia (HP:0003563)2.96394020
21Vacuolated lymphocytes (HP:0001922)2.95686901
22Congenital ichthyosiform erythroderma (HP:0007431)2.93037683
23Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87694964
24Congenital stationary night blindness (HP:0007642)2.86465752
25Hypoglycemic seizures (HP:0002173)2.84835979
26Abnormality of serum amino acid levels (HP:0003112)2.84557133
27Renal Fanconi syndrome (HP:0001994)2.75069600
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.69672136
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68187216
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.68083159
31Absent/shortened dynein arms (HP:0200106)2.68083159
32Pendular nystagmus (HP:0012043)2.65072572
33Eczematoid dermatitis (HP:0000976)2.64211518
34Abnormality of macrophages (HP:0004311)2.63258067
35Bile duct proliferation (HP:0001408)2.62343807
36Abnormal biliary tract physiology (HP:0012439)2.62343807
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.62049088
38Obstructive lung disease (HP:0006536)2.52274887
39Chronic obstructive pulmonary disease (HP:0006510)2.52274887
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51440561
41Exertional dyspnea (HP:0002875)2.51320253
42Abolished electroretinogram (ERG) (HP:0000550)2.50437834
43Spastic paraparesis (HP:0002313)2.50347944
44Abnormality of methionine metabolism (HP:0010901)2.50105092
45Intrahepatic cholestasis (HP:0001406)2.48763456
46Generalized aminoaciduria (HP:0002909)2.48468229
47Colon cancer (HP:0003003)2.46602676
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45566477
49Increased hepatocellular lipid droplets (HP:0006565)2.43514485
50Methylmalonic acidemia (HP:0002912)2.42436827
51Abnormality of urine glucose concentration (HP:0011016)2.38752424
52Glycosuria (HP:0003076)2.38752424
53Abnormal respiratory motile cilium physiology (HP:0012261)2.36236692
54Abnormality of the corticospinal tract (HP:0002492)2.35865452
55Prolonged neonatal jaundice (HP:0006579)2.35483992
56Pancreatic cysts (HP:0001737)2.33000992
57Abnormal respiratory epithelium morphology (HP:0012253)2.31365127
58Abnormal respiratory motile cilium morphology (HP:0005938)2.31365127
59Flat occiput (HP:0005469)2.30967659
60Cerebral inclusion bodies (HP:0100314)2.30931072
61Peripheral hypomyelination (HP:0007182)2.30641963
62Hypophosphatemic rickets (HP:0004912)2.29318775
63Split foot (HP:0001839)2.27749953
64Reduced antithrombin III activity (HP:0001976)2.27670584
65Hypoplastic pelvis (HP:0008839)2.26502584
66Symptomatic seizures (HP:0011145)2.23769907
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21600923
68Adrenal hypoplasia (HP:0000835)2.20928073
69Methylmalonic aciduria (HP:0012120)2.18836042
70Cerebral edema (HP:0002181)2.17077635
71Chromsome breakage (HP:0040012)2.16804044
72Meckel diverticulum (HP:0002245)2.16733955
73Curly hair (HP:0002212)2.16064046
74Lethargy (HP:0001254)2.15889763
75Abnormality of renal resorption (HP:0011038)2.15709183
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15516876
77Hyperlipoproteinemia (HP:0010980)2.14300902
78True hermaphroditism (HP:0010459)2.13922041
79Macrocytic anemia (HP:0001972)2.13797165
80Abnormality of the vitamin B12 metabolism (HP:0004341)2.13738897
81Premature rupture of membranes (HP:0001788)2.13244221
82Cerebral hypomyelination (HP:0006808)2.12611349
83Pancreatic fibrosis (HP:0100732)2.12395909
84Concave nail (HP:0001598)2.12363664
85Lipid accumulation in hepatocytes (HP:0006561)2.11344861
86Mitochondrial inheritance (HP:0001427)2.11162466
87Chronic bronchitis (HP:0004469)2.10602293
88Absent septum pellucidum (HP:0001331)2.10468538
89Abnormality of vitamin B metabolism (HP:0004340)2.10180214
90Abnormal ciliary motility (HP:0012262)2.09595155
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09295106
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07936156
93Abnormality of alanine metabolism (HP:0010916)2.07936156
94Hyperalaninemia (HP:0003348)2.07936156
95Abnormality of the ileum (HP:0001549)2.05848101
96Megaloblastic anemia (HP:0001889)2.05321164
97Abnormality of midbrain morphology (HP:0002418)2.05033930
98Molar tooth sign on MRI (HP:0002419)2.05033930
99Abnormality of vitamin metabolism (HP:0100508)2.03603820
100Metabolic alkalosis (HP:0200114)2.03392979
101Leukodystrophy (HP:0002415)2.02387515
102Increased CSF lactate (HP:0002490)2.01793096
103Birth length less than 3rd percentile (HP:0003561)2.01687112
1043-Methylglutaconic aciduria (HP:0003535)2.01178783
105Recurrent gram-negative bacterial infections (HP:0005420)2.00274032
106Decreased circulating renin level (HP:0003351)1.99230670
107Abnormality of the septum pellucidum (HP:0007375)1.97116354
108Episodic fever (HP:0001954)1.95611749
109Absent thumb (HP:0009777)1.95355161
110Hepatic necrosis (HP:0002605)1.95264397
111Optic disc pallor (HP:0000543)1.94356078
112Hyperphosphaturia (HP:0003109)1.94174474
113Impulsivity (HP:0100710)1.93785703
114Acute necrotizing encephalopathy (HP:0006965)1.93774459
115Septate vagina (HP:0001153)1.93217676
116Increased serum pyruvate (HP:0003542)1.92066167
117Abnormality of glycolysis (HP:0004366)1.92066167
118Overriding aorta (HP:0002623)1.90650699
119Chronic hepatic failure (HP:0100626)1.90017171
120Hypomagnesemia (HP:0002917)1.89983902
121Progressive external ophthalmoplegia (HP:0000590)1.89324414
122Clumsiness (HP:0002312)1.89318866
123Hepatosplenomegaly (HP:0001433)1.88455832
124Partial duplication of thumb phalanx (HP:0009944)1.88438447
125Aplasia/hypoplasia of the uterus (HP:0008684)1.87380257
126Increased intramyocellular lipid droplets (HP:0012240)1.87081677
127Abnormal urine phosphate concentration (HP:0012599)1.87044975
128Attenuation of retinal blood vessels (HP:0007843)1.86832203
129Erythroderma (HP:0001019)1.86156541
130Abnormality of pyrimidine metabolism (HP:0004353)1.84524070
131Abnormal rod and cone electroretinograms (HP:0008323)1.84513686
132Hypoglycemic coma (HP:0001325)1.84341598
133Retinal dysplasia (HP:0007973)1.83324866
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83142519
135Abnormal protein N-linked glycosylation (HP:0012347)1.83142519
136Abnormal protein glycosylation (HP:0012346)1.83142519
137Abnormal glycosylation (HP:0012345)1.83142519
138Supranuclear gaze palsy (HP:0000605)1.82896541
139Abnormal auditory evoked potentials (HP:0006958)1.81421175
140Absent radius (HP:0003974)1.80980642
141Hypoplasia of the pons (HP:0012110)1.80581145
142Hepatocellular necrosis (HP:0001404)1.80429590
143Vaginal fistula (HP:0004320)1.79182594
144Partial duplication of the phalanx of hand (HP:0009999)1.78955509
145Supernumerary spleens (HP:0009799)1.78895689
146Acute encephalopathy (HP:0006846)1.78385922
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.77828766
148Onion bulb formation (HP:0003383)1.77452326
149Increased circulating renin level (HP:0000848)1.76912294
150Hypolipoproteinemia (HP:0010981)1.76637536
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76440815
152Ketosis (HP:0001946)1.76286735
153Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75758351
154Abnormality of proline metabolism (HP:0010907)1.75629023
155Hydroxyprolinuria (HP:0003080)1.75629023
156Abnormal mitochondria in muscle tissue (HP:0008316)1.74494834
157Toxemia of pregnancy (HP:0100603)1.74351031
158Spontaneous abortion (HP:0005268)1.74287999
159Proximal tubulopathy (HP:0000114)1.73637474
160Recurrent bacterial skin infections (HP:0005406)1.73011324
161Rib fusion (HP:0000902)1.72839050
162Xanthomatosis (HP:0000991)1.72544236
163Areflexia of lower limbs (HP:0002522)1.72503619
164Increased serum lactate (HP:0002151)1.72262455
165Septo-optic dysplasia (HP:0100842)1.71554456
166Cerebral hemorrhage (HP:0001342)1.71459910
167Abnormality of the preputium (HP:0100587)1.70271239
168Hypokalemic alkalosis (HP:0001949)1.69831998
169Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68742510
170Dicarboxylic aciduria (HP:0003215)1.68742510
171Morphological abnormality of the pyramidal tract (HP:0002062)1.68363683
172Abnormality of the pons (HP:0007361)1.68061124
173Absent forearm bone (HP:0003953)1.68026790
174Aplasia involving forearm bones (HP:0009822)1.68026790
175Rickets (HP:0002748)1.68005782
176Horseshoe kidney (HP:0000085)1.67895613
177Hypoplasia of the uterus (HP:0000013)1.67808844
178Optic nerve hypoplasia (HP:0000609)1.67667250
179Reticulocytopenia (HP:0001896)1.67420343
180Abnormality of homocysteine metabolism (HP:0010919)1.66841883
181Megalencephaly (HP:0001355)1.66014198
182Abnormality of dental color (HP:0011073)1.65657022
183Decreased central vision (HP:0007663)1.65245414
184Myocardial infarction (HP:0001658)1.65003664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.08675470
2TLK13.95068313
3PBK3.76013215
4ZAK3.01581782
5OXSR12.87849029
6WNK42.71430517
7TESK22.71157231
8VRK22.53361648
9TRIM282.47881801
10ACVR1B2.47638550
11IRAK22.42073322
12TTK2.39616707
13EIF2AK12.32594450
14NME22.32308562
15WNK32.30371969
16IRAK12.19121995
17EPHB12.18373199
18MST42.11943665
19CDC72.11119079
20NEK92.09554123
21STK162.04861758
22PIM22.04290089
23MUSK1.98158227
24MAP4K21.88093869
25BRSK21.86614106
26CASK1.85300227
27PKN11.84560407
28BLK1.84222183
29IRAK41.80975813
30MAPK151.80221962
31BCR1.79647947
32CDK191.64876999
33PLK31.55301128
34CLK11.54687466
35TSSK61.51332018
36MET1.48083969
37IRAK31.48031752
38YES11.45456751
39GRK11.42480162
40PLK11.41094526
41FRK1.40721301
42DYRK1B1.37176182
43BCKDK1.35774205
44DYRK21.31252849
45FGR1.30757730
46TNIK1.26219744
47LIMK11.24860317
48PLK41.22627079
49ABL21.22278442
50BMPR1B1.20733459
51WNK11.20635898
52MAPKAPK51.10754647
53MAPKAPK31.07582798
54NEK21.07572963
55STK38L1.02643744
56CAMK2D1.01307704
57PINK11.00873025
58NEK10.98768972
59CSNK1G30.94530216
60PDK20.93264194
61FES0.92196764
62CSK0.91976531
63ATR0.89912578
64VRK10.89775263
65MKNK20.89011138
66WEE10.88607995
67CAMK2B0.88434197
68TAOK30.87694800
69BUB10.85219884
70DYRK30.82970549
71CSNK1G10.81576478
72STK30.81365235
73RPS6KA50.80887397
74TAF10.79338101
75BMX0.79298973
76CSNK1A1L0.78745749
77PNCK0.75181059
78UHMK10.74695330
79NUAK10.74441435
80ERBB20.74116374
81MAP2K20.73950482
82CAMK2G0.72652421
83PRKD20.72113576
84DAPK30.70705141
85NEK60.70139633
86STK240.69067970
87BRSK10.68827417
88SRPK10.68127192
89CHEK20.67522440
90MST1R0.66775596
91DMPK0.65390439
92AURKB0.64156218
93CDK70.63168027
94AURKA0.62681585
95CSNK1E0.61763343
96PRKCE0.60960531
97STK110.60027583
98PRKCQ0.59393227
99PRKCG0.58758713
100NLK0.58453339
101ADRBK10.56061318
102ATM0.55518802
103FER0.54045809
104CSNK2A10.53040226
105CHEK10.51331245
106CDK140.49366130
107ABL10.49200775
108MKNK10.48731906
109CSNK1A10.48496240
110MAP3K40.46816420
111CAMK2A0.45909648
112ADRBK20.45574422
113PRPF4B0.45124677
114MAPK130.45087686
115FGFR20.45014805
116FGFR10.44755138
117CDK90.44262961
118CSNK2A20.43943246
119DAPK10.43881743
120CSNK1G20.43609587
121PHKG10.43596542
122PHKG20.43596542
123ROCK20.43394280
124GRK70.41571854
125MAP3K90.40802659
126PRKD10.40614407
127STK40.40510512
128TEC0.40036229
129NTRK10.39019872
130HIPK20.38886520
131LCK0.38631207
132PAK10.38263180
133PAK30.38128128
134AKT30.36906619
135EPHA20.36313140
136CSNK1D0.35397432
137ERBB40.34818200
138EIF2AK30.32822260
139NME10.32329221
140IKBKB0.31417215
141CDK10.31243904
142PRKG10.30551432
143CDK20.30128025
144PRKG20.29651260
145INSRR0.29529408
146GSK3A0.29338207
147PRKAA20.28423895
148FYN0.27100986
149SGK2230.27019330
150SGK4940.27019330
151DYRK1A0.26782193
152PDGFRB0.26667145
153PRKCI0.25901373
154PIK3CA0.25553077
155LYN0.25492448
156PIK3CG0.24934721
157INSR0.24366516
158EIF2AK20.24050864

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.50065614
2Protein export_Homo sapiens_hsa030603.87592866
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.75160968
4Fatty acid elongation_Homo sapiens_hsa000623.23789180
5Phototransduction_Homo sapiens_hsa047443.00693901
6Ether lipid metabolism_Homo sapiens_hsa005652.89573605
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84927472
8Sulfur metabolism_Homo sapiens_hsa009202.62458811
9Oxidative phosphorylation_Homo sapiens_hsa001902.60092698
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53988146
11Folate biosynthesis_Homo sapiens_hsa007902.49131428
12Ribosome_Homo sapiens_hsa030102.45871151
13Sphingolipid metabolism_Homo sapiens_hsa006002.45039611
14Vitamin B6 metabolism_Homo sapiens_hsa007502.26998565
15Linoleic acid metabolism_Homo sapiens_hsa005912.24061277
16Caffeine metabolism_Homo sapiens_hsa002322.23788743
17Histidine metabolism_Homo sapiens_hsa003402.15760952
18Parkinsons disease_Homo sapiens_hsa050121.99538106
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97693292
20Mismatch repair_Homo sapiens_hsa034301.96677957
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.84451549
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79322139
23Propanoate metabolism_Homo sapiens_hsa006401.65335210
24DNA replication_Homo sapiens_hsa030301.60680441
25One carbon pool by folate_Homo sapiens_hsa006701.60094369
26Arginine biosynthesis_Homo sapiens_hsa002201.56734222
27Pyruvate metabolism_Homo sapiens_hsa006201.50614477
28Arachidonic acid metabolism_Homo sapiens_hsa005901.50428096
29Alzheimers disease_Homo sapiens_hsa050101.48872388
30RNA polymerase_Homo sapiens_hsa030201.48278179
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.45817996
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41582124
33Homologous recombination_Homo sapiens_hsa034401.38787173
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38312181
35Selenocompound metabolism_Homo sapiens_hsa004501.36610954
36Arginine and proline metabolism_Homo sapiens_hsa003301.31872569
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.30412727
38Retinol metabolism_Homo sapiens_hsa008301.28699476
39Huntingtons disease_Homo sapiens_hsa050161.28540386
40Base excision repair_Homo sapiens_hsa034101.28425047
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26612373
42Sulfur relay system_Homo sapiens_hsa041221.23260608
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23118610
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22650176
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22227525
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19357407
47Other glycan degradation_Homo sapiens_hsa005111.14767901
48Nitrogen metabolism_Homo sapiens_hsa009101.11936834
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11901666
50Biosynthesis of amino acids_Homo sapiens_hsa012301.07687356
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07006568
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03317297
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03252687
54Basal transcription factors_Homo sapiens_hsa030221.03236128
55RNA degradation_Homo sapiens_hsa030181.02772165
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00658669
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99852781
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99289859
59Starch and sucrose metabolism_Homo sapiens_hsa005000.98956142
60Non-homologous end-joining_Homo sapiens_hsa034500.98492323
61Butanoate metabolism_Homo sapiens_hsa006500.97991105
62Glutathione metabolism_Homo sapiens_hsa004800.97575123
63Phenylalanine metabolism_Homo sapiens_hsa003600.97303724
64RNA transport_Homo sapiens_hsa030130.96903296
65Peroxisome_Homo sapiens_hsa041460.95788499
66Nucleotide excision repair_Homo sapiens_hsa034200.94602578
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94232331
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94117355
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.90220270
70Pentose phosphate pathway_Homo sapiens_hsa000300.89516590
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89169379
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.88596970
73Fatty acid metabolism_Homo sapiens_hsa012120.86233176
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86221662
75Carbon metabolism_Homo sapiens_hsa012000.82099287
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81022666
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80800256
78Complement and coagulation cascades_Homo sapiens_hsa046100.75325362
79Metabolic pathways_Homo sapiens_hsa011000.74131461
80Tight junction_Homo sapiens_hsa045300.72684538
81Fructose and mannose metabolism_Homo sapiens_hsa000510.70730188
82Vitamin digestion and absorption_Homo sapiens_hsa049770.69927878
83Spliceosome_Homo sapiens_hsa030400.69717837
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68149481
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66828213
86Regulation of autophagy_Homo sapiens_hsa041400.66530842
87Lysosome_Homo sapiens_hsa041420.65459352
88Renal cell carcinoma_Homo sapiens_hsa052110.65323972
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.64015709
90Tryptophan metabolism_Homo sapiens_hsa003800.59903033
91Bile secretion_Homo sapiens_hsa049760.59466768
92Fat digestion and absorption_Homo sapiens_hsa049750.58926799
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56734484
94Cell cycle_Homo sapiens_hsa041100.56677542
95Long-term depression_Homo sapiens_hsa047300.56248737
96PPAR signaling pathway_Homo sapiens_hsa033200.55753589
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55681899
98Phagosome_Homo sapiens_hsa041450.55088847
99Serotonergic synapse_Homo sapiens_hsa047260.54725477
100Axon guidance_Homo sapiens_hsa043600.53822394
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53811495
102Cardiac muscle contraction_Homo sapiens_hsa042600.52582977
103Endocytosis_Homo sapiens_hsa041440.52232558
104Chemical carcinogenesis_Homo sapiens_hsa052040.51197056
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.50589440
106Vibrio cholerae infection_Homo sapiens_hsa051100.47353339
107Mineral absorption_Homo sapiens_hsa049780.46959370
108beta-Alanine metabolism_Homo sapiens_hsa004100.45998615
109Tyrosine metabolism_Homo sapiens_hsa003500.42146874
110Fanconi anemia pathway_Homo sapiens_hsa034600.42014345
111Renin-angiotensin system_Homo sapiens_hsa046140.41150811
112Glycerolipid metabolism_Homo sapiens_hsa005610.40735852
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36265799
114Rheumatoid arthritis_Homo sapiens_hsa053230.36120620
115Systemic lupus erythematosus_Homo sapiens_hsa053220.34845637
116Collecting duct acid secretion_Homo sapiens_hsa049660.32114243
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30535756
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30436781
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29492941
120Fatty acid degradation_Homo sapiens_hsa000710.29470901
121Autoimmune thyroid disease_Homo sapiens_hsa053200.27069619
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26644934
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.26323838
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25376408
125Malaria_Homo sapiens_hsa051440.23643422
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22920807
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.22703606
128Hedgehog signaling pathway_Homo sapiens_hsa043400.22658450
129Alcoholism_Homo sapiens_hsa050340.22188223
130Proteasome_Homo sapiens_hsa030500.22139675
131Shigellosis_Homo sapiens_hsa051310.21388127
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.21284812
133Ras signaling pathway_Homo sapiens_hsa040140.19914555
134ErbB signaling pathway_Homo sapiens_hsa040120.19726482
135Purine metabolism_Homo sapiens_hsa002300.19295722
136Pyrimidine metabolism_Homo sapiens_hsa002400.19231413
137Salmonella infection_Homo sapiens_hsa051320.18478933
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17945523

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