GRWD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.16324549
2purine nucleobase biosynthetic process (GO:0009113)4.95127734
3maturation of SSU-rRNA (GO:0030490)4.86359494
4formation of translation preinitiation complex (GO:0001731)4.78323220
5DNA replication initiation (GO:0006270)4.70603506
6ribosome assembly (GO:0042255)4.70318404
7DNA strand elongation involved in DNA replication (GO:0006271)4.67588770
8ribosome biogenesis (GO:0042254)4.66306916
9DNA deamination (GO:0045006)4.55660041
10DNA strand elongation (GO:0022616)4.43848803
11regulation of translational termination (GO:0006449)4.34398546
12telomere maintenance via semi-conservative replication (GO:0032201)4.30650480
13mitotic metaphase plate congression (GO:0007080)4.29089483
14DNA unwinding involved in DNA replication (GO:0006268)4.26711367
15ribonucleoprotein complex biogenesis (GO:0022613)4.23238517
16DNA replication checkpoint (GO:0000076)4.22540585
17peptidyl-arginine omega-N-methylation (GO:0035247)4.22427538
18IMP biosynthetic process (GO:0006188)4.19453965
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.18795244
20establishment of integrated proviral latency (GO:0075713)4.14181109
21histone arginine methylation (GO:0034969)4.04182112
22ribosomal large subunit biogenesis (GO:0042273)4.03637732
23ribosomal small subunit assembly (GO:0000028)4.00007324
24mitotic nuclear envelope disassembly (GO:0007077)3.93495509
25rRNA processing (GO:0006364)3.91531607
26mitotic chromosome condensation (GO:0007076)3.91132101
27protein localization to kinetochore (GO:0034501)3.89736688
28spliceosomal snRNP assembly (GO:0000387)3.89587407
29folic acid-containing compound biosynthetic process (GO:0009396)3.88034026
30DNA replication-dependent nucleosome assembly (GO:0006335)3.85648698
31DNA replication-dependent nucleosome organization (GO:0034723)3.85648698
32proteasome assembly (GO:0043248)3.82032517
33telomere maintenance via recombination (GO:0000722)3.79718475
34rRNA metabolic process (GO:0016072)3.78238804
35pseudouridine synthesis (GO:0001522)3.77981186
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73544134
37regulation of mitochondrial translation (GO:0070129)3.70303961
38folic acid metabolic process (GO:0046655)3.69725488
39rRNA modification (GO:0000154)3.67559152
40regulation of translational fidelity (GO:0006450)3.67013850
41membrane disassembly (GO:0030397)3.64846852
42nuclear envelope disassembly (GO:0051081)3.64846852
43transcription from mitochondrial promoter (GO:0006390)3.63537263
44IMP metabolic process (GO:0046040)3.62742594
45establishment of viral latency (GO:0019043)3.62532252
46ribosomal small subunit biogenesis (GO:0042274)3.58865557
47metaphase plate congression (GO:0051310)3.58354549
48mitotic recombination (GO:0006312)3.58125209
49nuclear pore organization (GO:0006999)3.56723236
50negative regulation of mRNA processing (GO:0050686)3.56563974
51CENP-A containing nucleosome assembly (GO:0034080)3.54843468
52protein complex localization (GO:0031503)3.54114022
53telomere maintenance via telomere lengthening (GO:0010833)3.53747199
54translational initiation (GO:0006413)3.53584267
55proline biosynthetic process (GO:0006561)3.52012645
56chromatin remodeling at centromere (GO:0031055)3.50637077
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.50167412
58translational termination (GO:0006415)3.49829858
59viral transcription (GO:0019083)3.49733191
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46155953
61nuclear envelope reassembly (GO:0031468)3.45816848
62mitotic nuclear envelope reassembly (GO:0007084)3.45816848
63nucleobase-containing small molecule interconversion (GO:0015949)3.45498471
64peptidyl-arginine methylation (GO:0018216)3.43941602
65peptidyl-arginine N-methylation (GO:0035246)3.43941602
66protein maturation by protein folding (GO:0022417)3.42187107
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42142269
68maturation of 5.8S rRNA (GO:0000460)3.40288420
69mitochondrial RNA metabolic process (GO:0000959)3.40109986
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37813077
71regulation of spindle organization (GO:0090224)3.35774074
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35686226
73rRNA transcription (GO:0009303)3.34791275
74translational elongation (GO:0006414)3.32701452
75DNA replication-independent nucleosome assembly (GO:0006336)3.31177428
76DNA replication-independent nucleosome organization (GO:0034724)3.31177428
77protein localization to chromosome, centromeric region (GO:0071459)3.30168395
78tRNA methylation (GO:0030488)3.29838261
79negative regulation of RNA splicing (GO:0033119)3.28887090
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.28618958
81termination of RNA polymerase III transcription (GO:0006386)3.27487992
82transcription elongation from RNA polymerase III promoter (GO:0006385)3.27487992
83negative regulation of mRNA metabolic process (GO:1903312)3.25264924
84transcription-coupled nucleotide-excision repair (GO:0006283)3.23643840
85nuclear pore complex assembly (GO:0051292)3.20569520
86cell cycle G1/S phase transition (GO:0044843)3.16942036
87G1/S transition of mitotic cell cycle (GO:0000082)3.16942036
88cellular protein complex localization (GO:0034629)3.15331817
89cellular component biogenesis (GO:0044085)3.15098560
90termination of RNA polymerase I transcription (GO:0006363)3.14156738
91mitotic sister chromatid segregation (GO:0000070)3.13915033
92establishment of chromosome localization (GO:0051303)3.13193901
93regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12461207
94transcription from RNA polymerase I promoter (GO:0006360)3.12426116
95negative regulation of ligase activity (GO:0051352)3.11724758
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11724758
97sister chromatid segregation (GO:0000819)3.11381404
98spliceosomal complex assembly (GO:0000245)3.09400036
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09352871
100transcription elongation from RNA polymerase I promoter (GO:0006362)3.08824577
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08005520
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07501229
103base-excision repair (GO:0006284)3.07161115
104heterochromatin organization (GO:0070828)3.07065217
105somatic hypermutation of immunoglobulin genes (GO:0016446)3.06260950
106somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06260950
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04606565
108DNA ligation (GO:0006266)3.04365806
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01588824
110pore complex assembly (GO:0046931)3.00626231
111histone exchange (GO:0043486)3.00349083
112viral mRNA export from host cell nucleus (GO:0046784)3.00199338
113ncRNA processing (GO:0034470)2.98886206
114DNA duplex unwinding (GO:0032508)2.97028014
115kinetochore organization (GO:0051383)2.96671029
116negative regulation of chromosome segregation (GO:0051985)2.95974529
117attachment of spindle microtubules to kinetochore (GO:0008608)2.95457696
118ncRNA metabolic process (GO:0034660)2.94300668
119pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.94002455
120DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92472130
121translation (GO:0006412)2.92169218
1227-methylguanosine mRNA capping (GO:0006370)2.92107743
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.91579942
124RNA splicing, via transesterification reactions (GO:0000375)2.91297167
125positive regulation of chromosome segregation (GO:0051984)2.91288208
126spindle checkpoint (GO:0031577)2.91048732
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90883894
128negative regulation of sister chromatid segregation (GO:0033046)2.90883894
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.90883894
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90883894
131rRNA methylation (GO:0031167)2.90668875
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.89779089
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88874531
134mRNA splicing, via spliceosome (GO:0000398)2.88874531
135signal transduction involved in DNA damage checkpoint (GO:0072422)2.88847714
136signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88847714
137pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88812417
138DNA geometric change (GO:0032392)2.88245308
139GDP-mannose metabolic process (GO:0019673)2.87247051
140L-serine metabolic process (GO:0006563)2.83829814
141tRNA aminoacylation for protein translation (GO:0006418)2.80850407
142tRNA aminoacylation (GO:0043039)2.76754617
143amino acid activation (GO:0043038)2.76754617
144ncRNA 3-end processing (GO:0043628)2.73838618
145mitochondrial fusion (GO:0008053)2.72138851
146termination of RNA polymerase II transcription (GO:0006369)2.68599074
147negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68156827
148chromatin assembly (GO:0031497)2.67787557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.54736164
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.62828421
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92021197
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.44868211
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28703890
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27756491
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22755103
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10253658
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07629600
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03927382
11* EST1_17652178_ChIP-ChIP_JURKAT_Human3.03716243
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.03261642
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.92715823
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83745367
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73335974
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46294117
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44825945
18XRN2_22483619_ChIP-Seq_HELA_Human2.42837040
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35704001
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27178774
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24522897
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23145462
23* VDR_23849224_ChIP-Seq_CD4+_Human2.21541617
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14034156
25AR_21909140_ChIP-Seq_LNCAP_Human2.07446637
26* DCP1A_22483619_ChIP-Seq_HELA_Human1.97885944
27GABP_19822575_ChIP-Seq_HepG2_Human1.96632555
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96505229
29FOXP3_21729870_ChIP-Seq_TREG_Human1.93185656
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92796449
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92325799
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89912854
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88298331
34TTF2_22483619_ChIP-Seq_HELA_Human1.87681092
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84835067
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.78625092
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77104698
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.74107909
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71501981
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70330442
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69547249
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63661632
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61863630
44CIITA_25753668_ChIP-Seq_RAJI_Human1.61793069
45* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58289249
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56734245
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54960521
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53731450
49ZNF263_19887448_ChIP-Seq_K562_Human1.52551270
50MYC_22102868_ChIP-Seq_BL_Human1.50858775
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49784760
52KDM5A_27292631_Chip-Seq_BREAST_Human1.49549872
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48949679
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.48942518
55* ELK1_19687146_ChIP-ChIP_HELA_Human1.47519380
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47448747
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45311884
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45227005
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.41317171
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40779245
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35208679
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34421600
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31337101
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.28412703
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27328679
66* NOTCH1_21737748_ChIP-Seq_TLL_Human1.20790039
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19719310
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19262224
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.18028750
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17627150
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16296723
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15836587
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15723620
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15091772
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14826320
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14227708
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13535607
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11097613
79TFEB_21752829_ChIP-Seq_HELA_Human1.09673048
80LXR_22292898_ChIP-Seq_THP-1_Human1.09524643
81RACK7_27058665_Chip-Seq_MCF-7_Human1.08720727
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07542183
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07170645
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06570150
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06443795
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05644735
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05614337
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.05053758
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04628113
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03854289
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.03457971
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02238235
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01859357
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01047972
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01026681
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01018705
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00815109
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99488664
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99406496
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99139420
101FOXP1_21924763_ChIP-Seq_HESCs_Human0.97698482
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97591924
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97356581
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97356581
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97356581
106MYC_18940864_ChIP-ChIP_HL60_Human0.95732630
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95635348
108* ELK1_22589737_ChIP-Seq_MCF10A_Human0.94949543
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94774909
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94298040
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93628749
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93396036
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93350103
114P68_20966046_ChIP-Seq_HELA_Human0.93294575
115ATF3_27146783_Chip-Seq_COLON_Human0.92985253
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91499155
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91222994
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90272601
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89452705
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84934071
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.84632864
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84369724
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83384624
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82582550
125VDR_21846776_ChIP-Seq_THP-1_Human0.81961015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.99874019
2MP0003111_abnormal_nucleus_morphology4.84961992
3MP0004957_abnormal_blastocyst_morpholog4.84421805
4MP0010094_abnormal_chromosome_stability4.61792532
5MP0003077_abnormal_cell_cycle4.16381679
6MP0008057_abnormal_DNA_replication3.87932989
7MP0008058_abnormal_DNA_repair3.53185103
8MP0008007_abnormal_cellular_replicative3.01763647
9MP0008932_abnormal_embryonic_tissue2.93016160
10MP0003123_paternal_imprinting2.80514109
11MP0001730_embryonic_growth_arrest2.70209620
12MP0005451_abnormal_body_composition2.57950223
13MP0003806_abnormal_nucleotide_metabolis2.52611782
14MP0000350_abnormal_cell_proliferation2.38186243
15MP0003786_premature_aging2.29517927
16MP0003718_maternal_effect2.22873775
17MP0002396_abnormal_hematopoietic_system2.18338354
18MP0008877_abnormal_DNA_methylation2.09301217
19MP0010352_gastrointestinal_tract_polyps2.02889411
20MP0001672_abnormal_embryogenesis/_devel1.98677132
21MP0005380_embryogenesis_phenotype1.98677132
22MP0001697_abnormal_embryo_size1.88224126
23MP0002877_abnormal_melanocyte_morpholog1.84843678
24MP0004185_abnormal_adipocyte_glucose1.83854294
25MP0002080_prenatal_lethality1.78094558
26MP0003984_embryonic_growth_retardation1.77409655
27MP0004233_abnormal_muscle_weight1.75270443
28MP0002088_abnormal_embryonic_growth/wei1.73392730
29MP0010307_abnormal_tumor_latency1.72924421
30MP0002085_abnormal_embryonic_tissue1.63168178
31MP0002796_impaired_skin_barrier1.57757283
32MP0000490_abnormal_crypts_of1.57148018
33MP0003567_abnormal_fetal_cardiomyocyte1.52263919
34MP0002086_abnormal_extraembryonic_tissu1.50376593
35MP0000313_abnormal_cell_death1.49953415
36MP0010030_abnormal_orbit_morphology1.47005559
37MP0002084_abnormal_developmental_patter1.46341580
38MP0001849_ear_inflammation1.45258936
39MP0009333_abnormal_splenocyte_physiolog1.42916734
40MP0002019_abnormal_tumor_incidence1.40287621
41MP0004197_abnormal_fetal_growth/weight/1.39781802
42MP0004133_heterotaxia1.32046751
43MP0001661_extended_life_span1.30006302
44MP0005623_abnormal_meninges_morphology1.28356746
45MP0001346_abnormal_lacrimal_gland1.26699202
46MP0009278_abnormal_bone_marrow1.24437083
47MP0009697_abnormal_copulation1.23369805
48MP0002210_abnormal_sex_determination1.20990735
49MP0003890_abnormal_embryonic-extraembry1.20380835
50MP0001293_anophthalmia1.18828863
51MP0003315_abnormal_perineum_morphology1.16065317
52MP0003566_abnormal_cell_adhesion1.15946890
53MP0006292_abnormal_olfactory_placode1.14400021
54MP0002254_reproductive_system_inflammat1.13790844
55MP0004808_abnormal_hematopoietic_stem1.13489834
56MP0001145_abnormal_male_reproductive1.12575760
57MP0002160_abnormal_reproductive_system1.11031222
58MP0010234_abnormal_vibrissa_follicle1.09754004
59MP0000358_abnormal_cell_content/1.08627285
60MP0003119_abnormal_digestive_system1.07226767
61MP0003186_abnormal_redox_activity1.05397980
62MP0001545_abnormal_hematopoietic_system1.05168506
63MP0005397_hematopoietic_system_phenotyp1.05168506
64MP0000537_abnormal_urethra_morphology1.01030608
65MP0002089_abnormal_postnatal_growth/wei0.98828016
66MP0000678_abnormal_parathyroid_gland0.98705478
67MP0005058_abnormal_lysosome_morphology0.97498277
68MP0003941_abnormal_skin_development0.96274210
69MP0003763_abnormal_thymus_physiology0.94242283
70MP0003121_genomic_imprinting0.94178358
71MP0000703_abnormal_thymus_morphology0.94086281
72MP0002132_abnormal_respiratory_system0.93907134
73MP0002653_abnormal_ependyma_morphology0.93814212
74MP0003453_abnormal_keratinocyte_physiol0.93809636
75MP0000653_abnormal_sex_gland0.92980672
76MP0003221_abnormal_cardiomyocyte_apopto0.92119206
77MP0001216_abnormal_epidermal_layer0.90257214
78MP0001929_abnormal_gametogenesis0.90000103
79MP0000003_abnormal_adipose_tissue0.88868705
80MP0006035_abnormal_mitochondrial_morpho0.88849892
81MP0003878_abnormal_ear_physiology0.88322071
82MP0005377_hearing/vestibular/ear_phenot0.88322071
83MP0009672_abnormal_birth_weight0.88208840
84MP0000750_abnormal_muscle_regeneration0.87780620
85MP0005076_abnormal_cell_differentiation0.85807978
86MP0002722_abnormal_immune_system0.85212760
87MP0002111_abnormal_tail_morphology0.84493847
88MP0005384_cellular_phenotype0.84342744
89MP0002060_abnormal_skin_morphology0.81486136
90MP0000689_abnormal_spleen_morphology0.81109162
91MP0005389_reproductive_system_phenotype0.80865035
92MP0006036_abnormal_mitochondrial_physio0.79025282
93MP0001243_abnormal_dermal_layer0.78783260
94MP0001873_stomach_inflammation0.78192743
95MP0001119_abnormal_female_reproductive0.78046943
96MP0002398_abnormal_bone_marrow0.77364889
97MP0005621_abnormal_cell_physiology0.77032863
98MP0009931_abnormal_skin_appearance0.72354285
99MP0005023_abnormal_wound_healing0.72055558
100MP0001881_abnormal_mammary_gland0.71392773
101MP0002970_abnormal_white_adipose0.71083030
102MP0000858_altered_metastatic_potential0.70866632
103MP0009053_abnormal_anal_canal0.69626770
104MP0002163_abnormal_gland_morphology0.68414959
105MP0009840_abnormal_foam_cell0.67797381
106MP0001915_intracranial_hemorrhage0.67757019
107MP0008260_abnormal_autophagy0.67333072
108MP0005257_abnormal_intraocular_pressure0.66395259
109MP0005266_abnormal_metabolism0.65968457
110MP0002429_abnormal_blood_cell0.65305823
111MP0005666_abnormal_adipose_tissue0.64893946
112MP0002098_abnormal_vibrissa_morphology0.64575476
113MP0005330_cardiomyopathy0.64475291
114MP0003937_abnormal_limbs/digits/tail_de0.64219665
115MP0000467_abnormal_esophagus_morphology0.64135101
116MP0000477_abnormal_intestine_morphology0.63746658
117MP0000579_abnormal_nail_morphology0.63437108
118MP0005375_adipose_tissue_phenotype0.62089026
119MP0001853_heart_inflammation0.61787823
120MP0002269_muscular_atrophy0.61385841
121MP0003943_abnormal_hepatobiliary_system0.61359234
122MP0000733_abnormal_muscle_development0.61152689
123MP0000762_abnormal_tongue_morphology0.60631691
124MP0004782_abnormal_surfactant_physiolog0.59446611
125MP0004858_abnormal_nervous_system0.58845261
126MP0005075_abnormal_melanosome_morpholog0.56165420
127MP0001286_abnormal_eye_development0.56109111
128MP0005395_other_phenotype0.55935733
129MP0000428_abnormal_craniofacial_morphol0.55131074
130MP0002092_abnormal_eye_morphology0.54437339
131MP0003705_abnormal_hypodermis_morpholog0.52261028
132MP0008770_decreased_survivor_rate0.51297500
133MP0001919_abnormal_reproductive_system0.50506553
134MP0009379_abnormal_foot_pigmentation0.50039236
135MP0001764_abnormal_homeostasis0.50001472
136MP0003699_abnormal_female_reproductive0.49920498
137MP0001727_abnormal_embryo_implantation0.49626931
138MP0003936_abnormal_reproductive_system0.48742985
139MP0005501_abnormal_skin_physiology0.48620710

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.77187274
2Breast hypoplasia (HP:0003187)4.89687213
3Microvesicular hepatic steatosis (HP:0001414)4.37364576
4Abnormality of cells of the erythroid lineage (HP:0012130)3.96559036
5Reticulocytopenia (HP:0001896)3.96326946
6Abnormal number of erythroid precursors (HP:0012131)3.81237661
7Oral leukoplakia (HP:0002745)3.76646207
8Cerebral hypomyelination (HP:0006808)3.76530765
9Carpal bone hypoplasia (HP:0001498)3.71211896
10Rough bone trabeculation (HP:0100670)3.65928891
11Selective tooth agenesis (HP:0001592)3.53564195
12Colon cancer (HP:0003003)3.53188102
13Patellar aplasia (HP:0006443)3.51829777
14Abnormality of the anterior horn cell (HP:0006802)3.51111290
15Degeneration of anterior horn cells (HP:0002398)3.51111290
16Testicular atrophy (HP:0000029)3.48175887
17Aplasia/Hypoplasia of the patella (HP:0006498)3.33433119
18Ragged-red muscle fibers (HP:0003200)3.21959856
19Absent radius (HP:0003974)3.07520846
20Absent thumb (HP:0009777)3.06799486
21Microretrognathia (HP:0000308)3.06573317
22Ependymoma (HP:0002888)3.05998124
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04637056
24Chromsome breakage (HP:0040012)2.99648593
25Aplastic anemia (HP:0001915)2.97673998
26Macrocytic anemia (HP:0001972)2.95658735
27Trismus (HP:0000211)2.93503503
28Medulloblastoma (HP:0002885)2.91268342
29Hyperacusis (HP:0010780)2.90011094
30Aplasia involving forearm bones (HP:0009822)2.88040164
31Absent forearm bone (HP:0003953)2.88040164
32Multiple enchondromatosis (HP:0005701)2.84288881
33Meckel diverticulum (HP:0002245)2.80004577
34Abnormality of the preputium (HP:0100587)2.79757382
35Abnormality of the labia minora (HP:0012880)2.76108071
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.75398723
37Premature ovarian failure (HP:0008209)2.74748385
38Impulsivity (HP:0100710)2.71936093
39Abnormality of the ileum (HP:0001549)2.69607308
40Abnormal trabecular bone morphology (HP:0100671)2.60678632
41Premature graying of hair (HP:0002216)2.59802191
42Progressive muscle weakness (HP:0003323)2.59351994
43Neoplasm of the pancreas (HP:0002894)2.57732319
44Agnosia (HP:0010524)2.56683986
45Spastic diplegia (HP:0001264)2.53787482
46Abnormality of chromosome stability (HP:0003220)2.53299820
47Progressive external ophthalmoplegia (HP:0000590)2.51959778
48Type I transferrin isoform profile (HP:0003642)2.46129561
49Proximal placement of thumb (HP:0009623)2.46093172
50Horseshoe kidney (HP:0000085)2.44028323
51Abnormal umbilical cord blood vessels (HP:0011403)2.42476476
52Single umbilical artery (HP:0001195)2.42476476
53Abnormality of the fetal cardiovascular system (HP:0010948)2.42476476
54Deviation of the thumb (HP:0009603)2.42149556
55Abnormal protein glycosylation (HP:0012346)2.42114379
56Abnormal glycosylation (HP:0012345)2.42114379
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42114379
58Abnormal protein N-linked glycosylation (HP:0012347)2.42114379
59Secondary amenorrhea (HP:0000869)2.42003796
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.41393133
61Pallor (HP:0000980)2.40706178
62Cellular immunodeficiency (HP:0005374)2.39271505
63High anterior hairline (HP:0009890)2.38225685
64Bone marrow hypocellularity (HP:0005528)2.36819196
6511 pairs of ribs (HP:0000878)2.33684349
66Small intestinal stenosis (HP:0012848)2.31406591
67Duodenal stenosis (HP:0100867)2.31406591
68Megaloblastic anemia (HP:0001889)2.30222479
69Reduced antithrombin III activity (HP:0001976)2.28873806
70Broad distal phalanx of finger (HP:0009836)2.27533756
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.26793813
72Supernumerary spleens (HP:0009799)2.26503383
73Septate vagina (HP:0001153)2.26048585
74Entropion (HP:0000621)2.25133659
75CNS hypomyelination (HP:0003429)2.24431327
76Myelodysplasia (HP:0002863)2.23755556
77Rhabdomyosarcoma (HP:0002859)2.23490119
78Abnormality of the umbilical cord (HP:0010881)2.21999516
79Poikiloderma (HP:0001029)2.21620170
80Tracheoesophageal fistula (HP:0002575)2.17526879
81Abnormal number of incisors (HP:0011064)2.16135529
82Slender long bone (HP:0003100)2.15596112
83Basal cell carcinoma (HP:0002671)2.15522370
84Cleft eyelid (HP:0000625)2.12925861
85Glossoptosis (HP:0000162)2.12615769
86Ureteral duplication (HP:0000073)2.11969014
87Achilles tendon contracture (HP:0001771)2.11832912
88Abnormalities of placenta or umbilical cord (HP:0001194)2.11474344
89Hypergonadotropic hypogonadism (HP:0000815)2.10837974
90Sloping forehead (HP:0000340)2.09095390
91Triphalangeal thumb (HP:0001199)2.09006174
92Abnormal lung lobation (HP:0002101)2.08350156
93Atresia of the external auditory canal (HP:0000413)2.07545771
94Aplasia/hypoplasia of the humerus (HP:0006507)2.07116235
95Increased serum pyruvate (HP:0003542)2.07048619
96Abnormality of glycolysis (HP:0004366)2.07048619
97Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05774437
98Abnormal gallbladder physiology (HP:0012438)2.03644211
99Cholecystitis (HP:0001082)2.03644211
100Facial cleft (HP:0002006)2.03287436
101Abnormality of the distal phalanges of the toes (HP:0010182)2.02564652
102Squamous cell carcinoma (HP:0002860)2.00795879
103Abnormality of the duodenum (HP:0002246)2.00311474
104Increased intramyocellular lipid droplets (HP:0012240)1.99543618
105Hypoplasia of the radius (HP:0002984)1.98677116
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98034346
107Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97682239
108Sparse eyelashes (HP:0000653)1.97340472
109Abnormality of pyrimidine metabolism (HP:0004353)1.96015353
110Increased muscle lipid content (HP:0009058)1.95491710
111Breast aplasia (HP:0100783)1.95432604
112Long palpebral fissure (HP:0000637)1.93823427
113Short thumb (HP:0009778)1.91714962
114Increased serum lactate (HP:0002151)1.91433223
115Irregular epiphyses (HP:0010582)1.91122164
116Self-mutilation (HP:0000742)1.90638354
117Nonimmune hydrops fetalis (HP:0001790)1.88189153
118Pancytopenia (HP:0001876)1.87869262
119Ectopic kidney (HP:0000086)1.86366530
120Duplicated collecting system (HP:0000081)1.86261892
121Insomnia (HP:0100785)1.86076975
122Distal lower limb amyotrophy (HP:0008944)1.85442379
123Aplasia/Hypoplasia of the breasts (HP:0010311)1.85411633
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85277771
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85277771
126Postnatal microcephaly (HP:0005484)1.84096655
127Abnormality of the calcaneus (HP:0008364)1.83735591
128IgA deficiency (HP:0002720)1.81115838
129Urethral obstruction (HP:0000796)1.80936463
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79999823
131Abnormality of abdominal situs (HP:0011620)1.79930307
132Abdominal situs inversus (HP:0003363)1.79930307
133Reduced subcutaneous adipose tissue (HP:0003758)1.78323537
134Personality changes (HP:0000751)1.77632081
135Glioma (HP:0009733)1.76390859
136Hypoplasia of the pons (HP:0012110)1.76324957
137Missing ribs (HP:0000921)1.73839966
138Increased nuchal translucency (HP:0010880)1.73815517
139Abnormality of the Achilles tendon (HP:0005109)1.73505526
140Astrocytoma (HP:0009592)1.73268543
141Abnormality of the astrocytes (HP:0100707)1.73268543
142Spinal muscular atrophy (HP:0007269)1.72336335
143Hypertensive crisis (HP:0100735)1.72307145
144Abnormality of subcutaneous fat tissue (HP:0001001)1.72281407
145Hyperalaninemia (HP:0003348)1.72242820
146Unilateral renal agenesis (HP:0000122)1.71221799
147Overriding aorta (HP:0002623)1.69988399
148Redundant skin (HP:0001582)1.69755416
149Abnormality of the columella (HP:0009929)1.67642748
150Exercise intolerance (HP:0003546)1.67555863
151Generalized amyotrophy (HP:0003700)1.67241194
152Ulnar bowing (HP:0003031)1.66821071
153Vertebral compression fractures (HP:0002953)1.65840946
154Opisthotonus (HP:0002179)1.65751377
155Premature skin wrinkling (HP:0100678)1.63148333
156Shoulder girdle muscle weakness (HP:0003547)1.62894018
157Lactic acidosis (HP:0003128)1.61458312
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.61432547
159Fasciculations (HP:0002380)1.61253854
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.60511147
161Prominent metopic ridge (HP:0005487)1.60253264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.46459034
2WEE14.43972634
3SMG13.83852736
4VRK23.54957344
5EIF2AK13.53025350
6CDC73.35864927
7TSSK63.16883137
8NEK22.61612432
9TRIB32.56851570
10NEK12.46324972
11NME22.44725267
12PLK42.30089336
13SRPK12.29114465
14TESK22.24370867
15TTK2.19339638
16BRSK22.11596008
17STK162.08844011
18EIF2AK32.03801107
19PLK11.99481345
20EPHA21.88332644
21MKNK11.79523882
22CDK71.75159060
23ACVR1B1.72324280
24PLK31.63262145
25VRK11.60612987
26DYRK31.58001117
27ICK1.55744769
28AURKB1.53166478
29MKNK21.51943860
30RPS6KB21.47064222
31BRSK11.46274220
32ATR1.42319374
33SCYL21.41303953
34AURKA1.37963106
35PASK1.33552979
36TLK11.31634973
37MAP3K81.31497228
38CHEK21.30980383
39RPS6KA41.27540454
40CCNB11.24217355
41KDR1.24175934
42CDK41.23568885
43ARAF1.22359221
44ZAK1.18178962
45TAF11.15883363
46PAK41.15463399
47CHEK11.14004001
48MST1R1.12126810
49STK101.11696672
50PIM21.11616370
51ERN11.08441831
52MAP3K111.04241791
53PRPF4B1.03015302
54TIE10.99693775
55SIK10.97965315
56CDK120.88228854
57AKT30.87849320
58TGFBR10.87721237
59ALK0.86100792
60TESK10.82389577
61CDK20.80720797
62EEF2K0.79396329
63LATS20.79362740
64PAK10.78929873
65BRAF0.76223764
66PNCK0.76191400
67STK38L0.74766274
68PRKCI0.74484035
69CSNK2A20.73868718
70NME10.73159642
71STK40.72281287
72BCKDK0.71692723
73PIM10.71654984
74LMTK20.71231662
75MAPK110.69415961
76TTN0.69348304
77ATM0.68885528
78CSNK2A10.67583850
79MAP4K10.66397890
80ABL20.66210959
81CSNK1G30.65254144
82LRRK20.63995927
83MAP2K20.63940771
84CDK80.62303871
85MAP2K30.59736811
86MAPKAPK30.59180373
87TAOK20.56711005
88PDK30.56283606
89PDK40.56283606
90IRAK20.55558411
91MAP3K100.54989164
92EIF2AK20.54589476
93CDK10.54453990
94CDK90.52630920
95CSNK1A1L0.52590955
96FLT30.49127117
97MELK0.48367034
98CSNK1E0.45591677
99CLK10.43528067
100DAPK30.40785618
101ERBB40.39177866
102AKT20.38461911
103PKN20.38231636
104MAP3K30.38114857
105CSNK1G10.37525622
106TAOK10.36549526
107TRIM280.35539278
108MTOR0.35248986
109CDK60.34390468
110BMX0.34155862
111LIMK10.33370122
112RPS6KA50.33117813
113ZAP700.31306036
114TBK10.31260333
115DAPK10.31098325
116RAF10.31043982
117DYRK20.30776924
118PTK20.30361143
119PDK20.30130636
120STK30.29985092
121GRK60.29884792
122FGFR10.27134239
123IRAK30.26216504
124ILK0.24418189
125PRKDC0.21777614
126PAK20.20886722
127PBK0.20422987
128TEC0.20030324

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74840915
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33830854
3Mismatch repair_Homo sapiens_hsa034304.14510037
4Proteasome_Homo sapiens_hsa030503.76239522
5RNA polymerase_Homo sapiens_hsa030203.72356459
6Ribosome_Homo sapiens_hsa030103.47281789
7Spliceosome_Homo sapiens_hsa030403.35705969
8RNA transport_Homo sapiens_hsa030133.35183946
9Base excision repair_Homo sapiens_hsa034102.91030346
10Nucleotide excision repair_Homo sapiens_hsa034202.79310961
11Homologous recombination_Homo sapiens_hsa034402.73200579
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70974360
13One carbon pool by folate_Homo sapiens_hsa006702.65666999
14Pyrimidine metabolism_Homo sapiens_hsa002402.64220955
15Cell cycle_Homo sapiens_hsa041102.53277682
16Fanconi anemia pathway_Homo sapiens_hsa034602.01402558
17Basal transcription factors_Homo sapiens_hsa030221.82524026
18RNA degradation_Homo sapiens_hsa030181.80511752
19Vitamin B6 metabolism_Homo sapiens_hsa007501.79454212
20Non-homologous end-joining_Homo sapiens_hsa034501.58720001
21mRNA surveillance pathway_Homo sapiens_hsa030151.56666629
22p53 signaling pathway_Homo sapiens_hsa041151.54266908
23Purine metabolism_Homo sapiens_hsa002301.48134607
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.32235463
25Biosynthesis of amino acids_Homo sapiens_hsa012301.28981152
26Folate biosynthesis_Homo sapiens_hsa007901.25550329
27Epstein-Barr virus infection_Homo sapiens_hsa051691.21434452
28Pentose phosphate pathway_Homo sapiens_hsa000301.16017951
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09603214
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04913965
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99476108
32Drug metabolism - other enzymes_Homo sapiens_hsa009830.98976226
33Selenocompound metabolism_Homo sapiens_hsa004500.96835984
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.95948843
35Sulfur relay system_Homo sapiens_hsa041220.94182446
36Oocyte meiosis_Homo sapiens_hsa041140.90734727
37Fatty acid elongation_Homo sapiens_hsa000620.89730140
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86639899
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84833177
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84557446
41Systemic lupus erythematosus_Homo sapiens_hsa053220.79783093
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78295413
43Carbon metabolism_Homo sapiens_hsa012000.78017907
44Viral carcinogenesis_Homo sapiens_hsa052030.76160542
45Antigen processing and presentation_Homo sapiens_hsa046120.73993648
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73951874
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72887439
48Fructose and mannose metabolism_Homo sapiens_hsa000510.68497544
49Chronic myeloid leukemia_Homo sapiens_hsa052200.68088448
50Herpes simplex infection_Homo sapiens_hsa051680.65463750
51Huntingtons disease_Homo sapiens_hsa050160.59551098
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59272121
53HTLV-I infection_Homo sapiens_hsa051660.59259280
54Glutathione metabolism_Homo sapiens_hsa004800.58296976
55Thyroid cancer_Homo sapiens_hsa052160.57194035
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57024433
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51098259
58Lysine degradation_Homo sapiens_hsa003100.50213469
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49462067
60Galactose metabolism_Homo sapiens_hsa000520.47971106
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47024152
62Pancreatic cancer_Homo sapiens_hsa052120.46005919
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45364260
64Legionellosis_Homo sapiens_hsa051340.43567448
65Non-small cell lung cancer_Homo sapiens_hsa052230.43425933
66Sulfur metabolism_Homo sapiens_hsa009200.43305073
67Parkinsons disease_Homo sapiens_hsa050120.42609668
68Vibrio cholerae infection_Homo sapiens_hsa051100.42163910
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38970026
70MicroRNAs in cancer_Homo sapiens_hsa052060.38260859
71Steroid biosynthesis_Homo sapiens_hsa001000.35076244
72Small cell lung cancer_Homo sapiens_hsa052220.34816041
73Hippo signaling pathway_Homo sapiens_hsa043900.34057764
74HIF-1 signaling pathway_Homo sapiens_hsa040660.34034960
75Arginine and proline metabolism_Homo sapiens_hsa003300.32399736
76Metabolic pathways_Homo sapiens_hsa011000.32039348
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31730612
78Regulation of autophagy_Homo sapiens_hsa041400.31546044
79Protein export_Homo sapiens_hsa030600.30904027
80Phenylalanine metabolism_Homo sapiens_hsa003600.30738412
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29104958
82Bladder cancer_Homo sapiens_hsa052190.28272209
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27895883
84Other glycan degradation_Homo sapiens_hsa005110.26976791
85Apoptosis_Homo sapiens_hsa042100.26394565
86TGF-beta signaling pathway_Homo sapiens_hsa043500.26344023
87Notch signaling pathway_Homo sapiens_hsa043300.26115038
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26031244
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25579209
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23943261
91Basal cell carcinoma_Homo sapiens_hsa052170.23296235
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.23203401
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21781792
94Oxidative phosphorylation_Homo sapiens_hsa001900.21456840
95Primary immunodeficiency_Homo sapiens_hsa053400.21436124
96Alzheimers disease_Homo sapiens_hsa050100.19988246
97Shigellosis_Homo sapiens_hsa051310.19287103
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18544741
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18107281
100Hepatitis C_Homo sapiens_hsa051600.18084202
101N-Glycan biosynthesis_Homo sapiens_hsa005100.17589054
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16334533
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15334722
104Vitamin digestion and absorption_Homo sapiens_hsa049770.14188199
105Colorectal cancer_Homo sapiens_hsa052100.14067732
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12538611
107Hedgehog signaling pathway_Homo sapiens_hsa043400.12052772
108Alcoholism_Homo sapiens_hsa050340.10903664
109Measles_Homo sapiens_hsa051620.10088074
110Hepatitis B_Homo sapiens_hsa051610.10061314
111Acute myeloid leukemia_Homo sapiens_hsa052210.08719618
112Pathways in cancer_Homo sapiens_hsa052000.08579006
113Pyruvate metabolism_Homo sapiens_hsa006200.07575005
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06891933
115Arachidonic acid metabolism_Homo sapiens_hsa005900.05332777
116Renin-angiotensin system_Homo sapiens_hsa046140.04950755
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.03756183
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03628700
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.02974641
120mTOR signaling pathway_Homo sapiens_hsa041500.02387796

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