GRXCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1righting reflex (GO:0060013)6.86792794
2* auditory receptor cell differentiation (GO:0042491)6.45952722
3DNA strand renaturation (GO:0000733)5.71667927
4face development (GO:0060324)5.17845857
5behavioral response to ethanol (GO:0048149)4.97831777
6negative regulation of organelle assembly (GO:1902116)4.76923475
7mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.63226512
8positive regulation of keratinocyte differentiation (GO:0045618)4.57485479
9cranial nerve morphogenesis (GO:0021602)4.49261755
10pentose metabolic process (GO:0019321)4.46420175
11glucocorticoid biosynthetic process (GO:0006704)4.13813766
12positive regulation of dendritic spine morphogenesis (GO:0061003)4.08770757
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.95942171
14cochlea morphogenesis (GO:0090103)3.87846532
15N-acetylglucosamine metabolic process (GO:0006044)3.85528314
16toxin transport (GO:1901998)3.83850827
17* hair cell differentiation (GO:0035315)3.78809537
18positive regulation of amino acid transport (GO:0051957)3.75999087
19metanephric mesenchyme development (GO:0072075)3.68129409
20short-term memory (GO:0007614)3.63784134
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.57056277
22inositol metabolic process (GO:0006020)3.55362822
23eyelid development in camera-type eye (GO:0061029)3.51081108
24reflex (GO:0060004)3.42797063
25positive regulation of vesicle fusion (GO:0031340)3.41820326
26negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.40470409
27positive regulation of epidermal cell differentiation (GO:0045606)3.36235847
28* inner ear receptor cell differentiation (GO:0060113)3.35203904
29notochord development (GO:0030903)3.33586277
30negative regulation of keratinocyte proliferation (GO:0010839)3.31428754
31keratinocyte development (GO:0003334)3.29410088
32cardiac right ventricle morphogenesis (GO:0003215)3.27788038
33head development (GO:0060322)3.26623500
34regulation of DNA damage checkpoint (GO:2000001)3.26573451
35kidney mesenchyme development (GO:0072074)3.25374209
36cell migration in hindbrain (GO:0021535)3.24683879
37single strand break repair (GO:0000012)3.22916429
38sulfation (GO:0051923)3.22329885
39regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.21542536
40positive regulation of protein dephosphorylation (GO:0035307)3.20261957
41negative regulation of leukocyte chemotaxis (GO:0002689)3.16671698
42glycine transport (GO:0015816)3.16404916
43mesenchymal to epithelial transition (GO:0060231)3.16164255
44cranial nerve development (GO:0021545)3.12051986
45pattern specification involved in kidney development (GO:0061004)3.11660722
46establishment of apical/basal cell polarity (GO:0035089)3.11231006
47adult feeding behavior (GO:0008343)3.07366743
48pathway-restricted SMAD protein phosphorylation (GO:0060389)3.07356537
49DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.05110915
50nephron tubule formation (GO:0072079)3.02196125
51glucosamine-containing compound metabolic process (GO:1901071)3.01168665
52sympathetic nervous system development (GO:0048485)3.00753179
53establishment or maintenance of monopolar cell polarity (GO:0061339)2.98346811
54establishment of monopolar cell polarity (GO:0061162)2.98346811
55regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95268273
56myelin assembly (GO:0032288)2.93818010
57cell differentiation involved in metanephros development (GO:0072202)2.93738549
58proline biosynthetic process (GO:0006561)2.88548442
59cellular response to ATP (GO:0071318)2.86198377
60urogenital system development (GO:0001655)2.85693359
61inner ear morphogenesis (GO:0042472)2.83667499
62neuron cell-cell adhesion (GO:0007158)2.83311790
63neuron fate specification (GO:0048665)2.79652963
64glucocorticoid metabolic process (GO:0008211)2.78223706
65regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76322691
66piRNA metabolic process (GO:0034587)2.74633536
67opioid receptor signaling pathway (GO:0038003)2.73823929
68* sensory perception of sound (GO:0007605)2.73572486
69* sensory perception of mechanical stimulus (GO:0050954)2.72368251
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71894922
71locomotory exploration behavior (GO:0035641)2.71024042
72* mechanoreceptor differentiation (GO:0042490)2.68139783
73pharyngeal system development (GO:0060037)2.67742053
74cellular response to cadmium ion (GO:0071276)2.67730697
75proximal/distal pattern formation (GO:0009954)2.67137531
76regulation of cAMP-dependent protein kinase activity (GO:2000479)2.66154261
77kidney morphogenesis (GO:0060993)2.61718156
78postsynaptic membrane organization (GO:0001941)2.61665667
79mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61219458
80mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61219458
81negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61177040
82dendritic spine morphogenesis (GO:0060997)2.60933481
83negative regulation of execution phase of apoptosis (GO:1900118)2.60733550
84synaptic vesicle exocytosis (GO:0016079)2.59886737
85positive regulation of metanephros development (GO:0072216)2.59178744
86negative regulation of granulocyte differentiation (GO:0030853)2.55636848
87ventricular system development (GO:0021591)2.52788946
88positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.51044780
89negative regulation of Ras GTPase activity (GO:0034261)2.50404705
90positive regulation of mesonephros development (GO:0061213)2.49927908
91diterpenoid biosynthetic process (GO:0016102)2.49484658
92startle response (GO:0001964)2.48945368
93phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.48712840
94RNA destabilization (GO:0050779)2.48301153
95regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46941688
96negative regulation of protein localization to cell surface (GO:2000009)2.45471600
97lateral sprouting from an epithelium (GO:0060601)2.44650553
98positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43552291
99adenosine metabolic process (GO:0046085)2.43447802
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43224365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83137965
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.19499888
3BMI1_23680149_ChIP-Seq_NPCS_Mouse2.82138749
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.61209990
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.53840871
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39307153
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37801074
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37801074
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36119075
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24657751
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.22958860
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22461094
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12226116
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10320626
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05789873
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.05150725
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99464295
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99430534
19AR_21572438_ChIP-Seq_LNCaP_Human1.92634520
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91769752
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91639822
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90152521
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.87759970
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.84820836
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81575878
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81575878
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81575878
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80190283
29DROSHA_22980978_ChIP-Seq_HELA_Human1.78993062
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78710388
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78696947
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74784395
33RNF2_27304074_Chip-Seq_NSC_Mouse1.63946096
34RING1B_27294783_Chip-Seq_NPCs_Mouse1.55678855
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54392614
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47655541
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41315106
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41315106
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.41296992
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40826792
41GBX2_23144817_ChIP-Seq_PC3_Human1.38018299
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.36851226
43VDR_22108803_ChIP-Seq_LS180_Human1.34084066
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.28644855
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28259179
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28067293
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27764153
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.26764609
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.24870320
50REST_21632747_ChIP-Seq_MESCs_Mouse1.24599621
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24097394
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21814651
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21184490
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.20451616
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.20011641
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19549252
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18384296
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.17887921
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16469653
60HTT_18923047_ChIP-ChIP_STHdh_Human1.14739574
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.14560188
62CTCF_27219007_Chip-Seq_Bcells_Human1.13760995
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13669545
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13234301
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11710142
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.10870326
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09910546
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09218258
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09184420
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06601880
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.06004272
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.05322663
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05179544
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04776603
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04244567
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.03926532
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.02568571
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02124170
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01945596
80P300_18555785_Chip-Seq_ESCs_Mouse1.01727407
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.01451757
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00298627
83TP53_18474530_ChIP-ChIP_U2OS_Human0.99853198
84NANOG_18555785_Chip-Seq_ESCs_Mouse0.99662938
85SMAD4_21799915_ChIP-Seq_A2780_Human0.99064456
86NMYC_18555785_Chip-Seq_ESCs_Mouse0.98947976
87RUNX2_22187159_ChIP-Seq_PCA_Human0.97104847
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96788386
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96099316
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95651908
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95257917
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94437982
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.93387202
94KDM2B_26808549_Chip-Seq_K562_Human0.93197750
95ETV1_20927104_ChIP-Seq_GIST48_Human0.92614386
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.91826521
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91590037
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.91315496
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90945888
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90751259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell4.77981328
2MP0001485_abnormal_pinna_reflex4.75401835
3MP0002102_abnormal_ear_morphology4.70792236
4MP0003878_abnormal_ear_physiology3.84360347
5MP0005377_hearing/vestibular/ear_phenot3.84360347
6* MP0000026_abnormal_inner_ear2.98285598
7* MP0001963_abnormal_hearing_physiology2.91630951
8* MP0001486_abnormal_startle_reflex2.84799057
9MP0008995_early_reproductive_senescence2.83708823
10MP0005645_abnormal_hypothalamus_physiol2.81516808
11MP0009278_abnormal_bone_marrow2.67675869
12MP0000566_synostosis2.51716612
13MP0003938_abnormal_ear_development2.45494350
14MP0005623_abnormal_meninges_morphology2.41656987
15MP0006072_abnormal_retinal_apoptosis2.40147000
16MP0000383_abnormal_hair_follicle2.02044873
17MP0002249_abnormal_larynx_morphology1.99976674
18MP0002938_white_spotting1.92816243
19MP0000013_abnormal_adipose_tissue1.87425067
20* MP0004742_abnormal_vestibular_system1.86702040
21MP0002139_abnormal_hepatobiliary_system1.74294642
22MP0003890_abnormal_embryonic-extraembry1.65326304
23MP0000049_abnormal_middle_ear1.63505957
24MP0003942_abnormal_urinary_system1.59959883
25MP0010678_abnormal_skin_adnexa1.54999619
26MP0005248_abnormal_Harderian_gland1.54127232
27MP0002751_abnormal_autonomic_nervous1.50021413
28MP0004885_abnormal_endolymph1.48894721
29MP0004019_abnormal_vitamin_homeostasis1.47813904
30MP0002653_abnormal_ependyma_morphology1.38092707
31MP0001968_abnormal_touch/_nociception1.35648262
32MP0010368_abnormal_lymphatic_system1.35573031
33MP0005451_abnormal_body_composition1.31056259
34MP0005187_abnormal_penis_morphology1.30362853
35MP0002184_abnormal_innervation1.28376921
36MP0003786_premature_aging1.28340399
37MP0008789_abnormal_olfactory_epithelium1.23857625
38MP0002697_abnormal_eye_size1.23438814
39MP0004859_abnormal_synaptic_plasticity1.23086166
40* MP0002752_abnormal_somatic_nervous1.22769472
41MP0005670_abnormal_white_adipose1.22689061
42MP0002733_abnormal_thermal_nociception1.20828043
43MP0000534_abnormal_ureter_morphology1.17195838
44MP0005085_abnormal_gallbladder_physiolo1.16997705
45MP0000579_abnormal_nail_morphology1.14945461
46MP0000613_abnormal_salivary_gland1.12641695
47MP0005174_abnormal_tail_pigmentation1.11311471
48MP0001340_abnormal_eyelid_morphology1.10442297
49MP0003045_fibrosis1.09927434
50MP0010030_abnormal_orbit_morphology1.07451158
51MP0000647_abnormal_sebaceous_gland1.06372477
52MP0005253_abnormal_eye_physiology1.05489734
53MP0002098_abnormal_vibrissa_morphology1.05484957
54MP0005423_abnormal_somatic_nervous1.04709067
55MP0000762_abnormal_tongue_morphology1.03500937
56MP0001970_abnormal_pain_threshold1.03486024
57MP0003453_abnormal_keratinocyte_physiol1.01538004
58MP0003137_abnormal_impulse_conducting1.00982421
59MP0009780_abnormal_chondrocyte_physiolo1.00670357
60MP0002116_abnormal_craniofacial_bone1.00312363
61MP0009745_abnormal_behavioral_response0.98294972
62MP0001986_abnormal_taste_sensitivity0.96015383
63MP0001286_abnormal_eye_development0.95067132
64MP0005171_absent_coat_pigmentation0.93426328
65MP0002796_impaired_skin_barrier0.92795617
66* MP0002067_abnormal_sensory_capabilities0.91516936
67MP0000465_gastrointestinal_hemorrhage0.91131038
68MP0002572_abnormal_emotion/affect_behav0.90208701
69MP0000778_abnormal_nervous_system0.90104252
70MP0002557_abnormal_social/conspecific_i0.89598562
71MP0001501_abnormal_sleep_pattern0.88675531
72* MP0002272_abnormal_nervous_system0.87509494
73MP0003787_abnormal_imprinting0.87199945
74MP0003635_abnormal_synaptic_transmissio0.84794450
75MP0010352_gastrointestinal_tract_polyps0.81906208
76MP0002111_abnormal_tail_morphology0.81694592
77MP0004270_analgesia0.81138486
78MP0008877_abnormal_DNA_methylation0.80734157
79MP0002282_abnormal_trachea_morphology0.80542543
80MP0002063_abnormal_learning/memory/cond0.79863018
81MP0002233_abnormal_nose_morphology0.78374904
82MP0000462_abnormal_digestive_system0.76711548
83* MP0002882_abnormal_neuron_morphology0.73020690
84MP0009046_muscle_twitch0.70380445
85MP0005195_abnormal_posterior_eye0.69587232
86MP0005391_vision/eye_phenotype0.68259249
87MP0000631_abnormal_neuroendocrine_gland0.67580103
88MP0005365_abnormal_bile_salt0.67314331
89MP0003385_abnormal_body_wall0.67240938
90MP0002064_seizures0.67096028
91MP0001664_abnormal_digestion0.66854371
92* MP0002066_abnormal_motor_capabilities/c0.66447895
93MP0005394_taste/olfaction_phenotype0.66392509
94MP0005499_abnormal_olfactory_system0.66392509
95MP0008874_decreased_physiological_sensi0.66181005
96MP0003935_abnormal_craniofacial_develop0.65618691
97MP0002277_abnormal_respiratory_mucosa0.65211816
98MP0002932_abnormal_joint_morphology0.65122501
99MP0000955_abnormal_spinal_cord0.63069409
100MP0003868_abnormal_feces_composition0.62878686

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)5.85063354
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.57120495
3Abnormality of the renal collecting system (HP:0004742)5.48851192
4Intestinal atresia (HP:0011100)5.23375862
5Lip pit (HP:0100267)4.77821401
6Chromsome breakage (HP:0040012)4.49387300
7Unilateral renal agenesis (HP:0000122)4.07803473
8Reticulocytopenia (HP:0001896)3.93012953
9Mixed hearing impairment (HP:0000410)3.78913370
10Bilateral sensorineural hearing impairment (HP:0008619)3.75954902
11Hypoplasia of the fovea (HP:0007750)3.68935302
12Aplasia/Hypoplasia of the fovea (HP:0008060)3.68935302
13Bilateral microphthalmos (HP:0007633)3.66883044
14Fused cervical vertebrae (HP:0002949)3.53612807
15Congenital stationary night blindness (HP:0007642)3.36484083
16Renal agenesis (HP:0000104)3.35442739
17Abnormality of DNA repair (HP:0003254)3.29882685
18Abnormality of dentin (HP:0010299)3.15235186
19Gastrointestinal atresia (HP:0002589)3.10704170
20Duplication of thumb phalanx (HP:0009942)3.01497050
21Absent radius (HP:0003974)2.95199772
22Morphological abnormality of the middle ear (HP:0008609)2.91266474
23Ectopic anus (HP:0004397)2.90868640
24Upper limb muscle weakness (HP:0003484)2.88662614
25Absent thumb (HP:0009777)2.87896168
26Abnormality of pyrimidine metabolism (HP:0004353)2.86683501
27Aplasia involving forearm bones (HP:0009822)2.86149747
28Absent forearm bone (HP:0003953)2.86149747
29Increased IgM level (HP:0003496)2.80664776
30Hypochromic microcytic anemia (HP:0004840)2.80621003
31Squamous cell carcinoma (HP:0002860)2.72996045
32Ureteral duplication (HP:0000073)2.72450985
33Abnormality of the fovea (HP:0000493)2.57597040
34Severe Myopia (HP:0011003)2.54064090
35Annular pancreas (HP:0001734)2.48287652
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47168043
37Aplasia/Hypoplasia of the macula (HP:0008059)2.41865221
38Lower limb amyotrophy (HP:0007210)2.37249997
39Facial shape deformation (HP:0011334)2.36149061
40Potter facies (HP:0002009)2.36149061
41Alacrima (HP:0000522)2.35649142
42Mesomelia (HP:0003027)2.34209042
43Osteomalacia (HP:0002749)2.32882318
44Abnormality of the ileum (HP:0001549)2.30951226
45Chorioretinal atrophy (HP:0000533)2.26771213
46Ectopic kidney (HP:0000086)2.26677276
47Distal lower limb amyotrophy (HP:0008944)2.25682600
48Coronal craniosynostosis (HP:0004440)2.25564801
49Distal lower limb muscle weakness (HP:0009053)2.24262785
50Overfolded helix (HP:0000396)2.24051717
51Congenital sensorineural hearing impairment (HP:0008527)2.23050983
52Intrahepatic cholestasis (HP:0001406)2.20695953
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.17559735
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17559735
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.14581509
56Horseshoe kidney (HP:0000085)2.13936317
57Meckel diverticulum (HP:0002245)2.11830404
58Vertebral fusion (HP:0002948)2.09258482
59Anteriorly placed anus (HP:0001545)2.07999754
60Hyperthyroidism (HP:0000836)2.07591016
61Turricephaly (HP:0000262)2.04622430
62Esophageal atresia (HP:0002032)2.03720067
63Papillary thyroid carcinoma (HP:0002895)2.01842118
64Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01422477
65Abnormally folded helix (HP:0008544)2.01298461
66Prostate neoplasm (HP:0100787)2.00784064
67Renal hypoplasia (HP:0000089)1.99668474
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98982556
69Abnormality of the duodenum (HP:0002246)1.98830936
70Short thumb (HP:0009778)1.96893429
71Bicornuate uterus (HP:0000813)1.96408268
72Epiphyseal dysplasia (HP:0002656)1.95000322
73Abnormality of the preputium (HP:0100587)1.94775810
74Anophthalmia (HP:0000528)1.91601184
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87863298
76Hypoplastic ischia (HP:0003175)1.87191538
77Atelectasis (HP:0100750)1.85524451
78Dysautonomia (HP:0002459)1.82041694
79Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80484132
80Morphological abnormality of the inner ear (HP:0011390)1.79892117
81Febrile seizures (HP:0002373)1.79286643
82Hepatoblastoma (HP:0002884)1.78824210
83Cupped ear (HP:0000378)1.78249127
84Abnormality of the pubic bones (HP:0003172)1.77140454
85Decreased motor nerve conduction velocity (HP:0003431)1.76367987
86Exotropia (HP:0000577)1.75465076
87Down-sloping shoulders (HP:0200021)1.74533754
88Progressive sensorineural hearing impairment (HP:0000408)1.70588600
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70155010
90Acute lymphatic leukemia (HP:0006721)1.68519854
91Abnormal respiratory epithelium morphology (HP:0012253)1.68313909
92Abnormal respiratory motile cilium morphology (HP:0005938)1.68313909
93Facial cleft (HP:0002006)1.68140042
94Abnormality of the antihelix (HP:0009738)1.67574210
95Abnormal hemoglobin (HP:0011902)1.67542508
96Skin pits (HP:0100276)1.67387483
97Parakeratosis (HP:0001036)1.67166884
98Myocardial infarction (HP:0001658)1.66681512
99Abnormality of the corticospinal tract (HP:0002492)1.66415224
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.64576306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.57481251
2NTRK33.84604968
3MAPK153.00501630
4CASK2.85399042
5GRK12.53936847
6KSR12.51521310
7PAK62.50701776
8PDGFRA2.35350466
9LATS22.30292695
10LATS12.19040675
11EIF2AK22.11127116
12ADRBK22.09511304
13UHMK12.03747023
14ICK1.81135279
15PIK3CG1.79852237
16DYRK1B1.79022407
17PINK11.65174311
18TNIK1.59141581
19KSR21.56322446
20FGR1.56229371
21CDC42BPA1.55725372
22MARK11.50972086
23DYRK21.40744893
24HIPK21.38979473
25IRAK21.38296078
26WNK41.32184370
27PAK31.30860058
28EPHB11.28719293
29MAP3K61.24575487
30TRPM71.20492029
31CLK11.20178992
32YES11.17720022
33EPHA31.15881791
34RIPK11.15768434
35EPHB21.11738889
36PHKG21.09823525
37PHKG11.09823525
38NME11.04741479
39MARK31.01292635
40FER1.00105362
41ALK0.98059001
42MAP3K90.94686583
43ERBB40.93539931
44EPHA20.91468330
45BMPR1B0.90542192
46PRKD20.89932467
47PRPF4B0.88152903
48TYRO30.87241191
49STK390.86975098
50PRKAA10.85278600
51WNK10.85248627
52CAMK2A0.83300097
53MAP2K70.81750003
54SIK20.81280639
55STK30.79792541
56PAK20.79564703
57MATK0.78241563
58CSK0.78001545
59ERBB30.75417616
60NTRK20.70769940
61PKN10.70178466
62FGFR40.69412772
63MAP3K20.69155500
64CDK70.66979902
65ADRBK10.65135223
66MAP3K40.64650378
67GSK3A0.59373469
68PRKAA20.57465220
69TTK0.56012636
70DAPK10.53308181
71SGK10.50527500
72PDGFRB0.49989524
73NTRK10.47593892
74PRKD30.46898523
75MKNK20.45659607
76PTK20.44303479
77RAF10.44249339
78CSNK1G10.44181895
79CAMK2B0.43349083
80STK160.42625924
81HCK0.42514391
82BLK0.42078471
83DAPK20.40567236
84CSNK1A1L0.40485346
85IRAK10.40137305
86CDK50.39405153
87SIK10.37255644
88PRKCE0.37216648
89PRKCZ0.37131726
90MAP2K10.36604072
91CSNK1E0.35980192
92ERBB20.34911491
93MAPK130.34757251
94BCR0.33480704
95PRKCG0.32213358
96SRC0.32182892
97INSRR0.31321698
98CAMK2D0.30698378
99STK110.30450622
100PIM10.30381796

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.25587090
2Phenylalanine metabolism_Homo sapiens_hsa003603.01927922
3beta-Alanine metabolism_Homo sapiens_hsa004102.68369084
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.68160985
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.59770245
6Fatty acid biosynthesis_Homo sapiens_hsa000612.46155378
7Histidine metabolism_Homo sapiens_hsa003402.04724688
8Linoleic acid metabolism_Homo sapiens_hsa005911.91922535
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76780060
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.74678348
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.60949792
12Ether lipid metabolism_Homo sapiens_hsa005651.59941948
13Taste transduction_Homo sapiens_hsa047421.59379227
14Inositol phosphate metabolism_Homo sapiens_hsa005621.57378541
15Ovarian steroidogenesis_Homo sapiens_hsa049131.56430241
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.50282726
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43305089
18Caffeine metabolism_Homo sapiens_hsa002321.37339521
19Serotonergic synapse_Homo sapiens_hsa047261.35365495
20Phototransduction_Homo sapiens_hsa047441.32928874
21Tyrosine metabolism_Homo sapiens_hsa003501.30329769
22ABC transporters_Homo sapiens_hsa020101.29746631
23Fanconi anemia pathway_Homo sapiens_hsa034601.26109215
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24296012
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23825600
26ECM-receptor interaction_Homo sapiens_hsa045121.22383940
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21080735
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.19890417
29TGF-beta signaling pathway_Homo sapiens_hsa043501.18171329
30Glutamatergic synapse_Homo sapiens_hsa047241.17918937
31Morphine addiction_Homo sapiens_hsa050321.17889440
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15694157
33Axon guidance_Homo sapiens_hsa043601.14237213
34Arginine and proline metabolism_Homo sapiens_hsa003301.13460832
35Fatty acid elongation_Homo sapiens_hsa000621.08579111
36GABAergic synapse_Homo sapiens_hsa047271.05567519
37Hippo signaling pathway_Homo sapiens_hsa043901.04774798
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03627607
39Dilated cardiomyopathy_Homo sapiens_hsa054141.02668416
40Dorso-ventral axis formation_Homo sapiens_hsa043201.02383646
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01314855
42Tryptophan metabolism_Homo sapiens_hsa003800.98336054
43Estrogen signaling pathway_Homo sapiens_hsa049150.98038104
44Lysine degradation_Homo sapiens_hsa003100.97962382
45Viral myocarditis_Homo sapiens_hsa054160.95603207
46ErbB signaling pathway_Homo sapiens_hsa040120.92201969
47Fatty acid metabolism_Homo sapiens_hsa012120.92126441
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85483817
49Nicotine addiction_Homo sapiens_hsa050330.84408258
50Protein digestion and absorption_Homo sapiens_hsa049740.83964465
51Insulin secretion_Homo sapiens_hsa049110.83811901
52Cocaine addiction_Homo sapiens_hsa050300.83355679
53Butanoate metabolism_Homo sapiens_hsa006500.83272229
54Amphetamine addiction_Homo sapiens_hsa050310.82899395
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81682630
56Notch signaling pathway_Homo sapiens_hsa043300.81280749
57Ras signaling pathway_Homo sapiens_hsa040140.80357805
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.80220140
59Hedgehog signaling pathway_Homo sapiens_hsa043400.77943271
60Melanogenesis_Homo sapiens_hsa049160.77779926
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75496357
62Dopaminergic synapse_Homo sapiens_hsa047280.75494829
63Gastric acid secretion_Homo sapiens_hsa049710.74316097
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74177996
65Wnt signaling pathway_Homo sapiens_hsa043100.73663303
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73464853
67GnRH signaling pathway_Homo sapiens_hsa049120.70846024
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70687090
69Arachidonic acid metabolism_Homo sapiens_hsa005900.70610554
70Olfactory transduction_Homo sapiens_hsa047400.68926746
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67956810
72Long-term depression_Homo sapiens_hsa047300.67114211
73Focal adhesion_Homo sapiens_hsa045100.66963050
74MicroRNAs in cancer_Homo sapiens_hsa052060.66734528
75cAMP signaling pathway_Homo sapiens_hsa040240.62626878
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62399249
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62141467
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61532633
79Complement and coagulation cascades_Homo sapiens_hsa046100.61178699
80Basal cell carcinoma_Homo sapiens_hsa052170.60866417
81Tight junction_Homo sapiens_hsa045300.59896718
82Oxytocin signaling pathway_Homo sapiens_hsa049210.58397879
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54800888
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54230782
85MAPK signaling pathway_Homo sapiens_hsa040100.53220429
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.52492316
87Calcium signaling pathway_Homo sapiens_hsa040200.52097841
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51994152
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50789387
90Colorectal cancer_Homo sapiens_hsa052100.50323119
91Prion diseases_Homo sapiens_hsa050200.49337687
92Circadian entrainment_Homo sapiens_hsa047130.49278567
93Choline metabolism in cancer_Homo sapiens_hsa052310.48447341
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47539268
95Cholinergic synapse_Homo sapiens_hsa047250.45558122
96Circadian rhythm_Homo sapiens_hsa047100.45383884
97Retinol metabolism_Homo sapiens_hsa008300.44463183
98VEGF signaling pathway_Homo sapiens_hsa043700.41007551
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40997018
100Rap1 signaling pathway_Homo sapiens_hsa040150.40648192

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »